An insecticide composition containing amide insecticides and its application

Abstract

The present invention belongs to the field of pesticide insecticide technology and discloses an insecticidal composition containing an amide insecticide and its use. The active ingredients of the insecticidal composition include active ingredient A and active ingredient B, wherein active ingredient A is a compound represented by formula I; active ingredient B is an amide insecticide, and the amide insecticide is any one of tolfenpyrad, chlorfluanid, tetrachlorantraniliprole, polyflubenzuron, sulfanilamide, and sulfenylamide; and the mass ratio of active ingredient A to active ingredient B is 1:40 to 40:1. The insecticidal composition of the present invention significantly improves insecticidal efficacy, increases the utilization rate of the pesticide, slows the development of pest resistance, and extends the service life of the pesticide.

Description

Technical Field

[0001] The invention belongs to the technical field of pesticide killing, and discloses an insecticidal composition containing an amide insecticide and application thereof. Background Art

[0002] Amide insecticides have diverse and novel structures, rich and unique mechanisms of action, and excellent and broad-spectrum insect control effects.

[0003] Tolfenpyrad, English common name: tolfenpyrad, CAS registration number: 129558-76-5, chemical name: 4-chloro-5-ethyl-2-methyl-N-[[4-(4-methylphenoxy)phenyl]methyl]pyrazole-3-carboxamide, its structural formula is as follows:

[0004]

[0005] Cyhalodiamide, common name in English: cyhalodiamide, CAS registration number: 1262605-53-7, chemical name: 3-chloro-2-N-(2-cyanopropyl-2-yl)-1-N-[4-(1,1,1,2,3,3,3-heptafluoroprop-2-yl)-2-methylphenyl]benzene-1,2-dicarboxamide, its structural formula is as follows:

[0006]

[0007] Tetrachlorantraniliprole, common name in English: tetrachlorantraniliprole, CAS registration number: 1104384-14-6, chemical name: 3-bromo-N-(2,4-dichloro-6-(methylcarbamoyl)phenyl)-1-(3,5-dichloropyridin-2-yl)-1H-pyrazole-5-carboxamide, its structural formula is as follows:

[0008]

[0009] Piperflanilide, common name in English: piperflanilide, CAS registration number: 2615135-05-0, chemical name: N-(3-{[2-bromo-6-(difluoromethoxy)-4-(1,1,1,2,3,3,3-heptafluoropropyl-2-yl)phenyl]carbamoyl}-2-fluorophenyl)-2,2-difluoro-N-methyl-2H-1,3-benzodioxolane-5-carboxamide, its structural formula is as follows:

[0010]

[0011] Thioantraniliprole, international common name: tiorantraniliprole, CAS registration number: 1442448-92-1, chemical name: 5-bromo-2-(3-chloropyridin-2-yl)-N-[2,4-dichloro-6-(propan-2-ylaminomethylsulfonyl)phenyl]pyrazole-3-carboxamide, its structural formula is as follows:

[0012]

[0013] Thiocyclamide, international common name: pioxaniliprole, CAS registration number: 2368920-61-8, chemical name: N-[2-(tert-butylcarbamoyl)-4-chloro-6-methylphenyl]-1-(3-chloropyridin-2-yl)-3-[(1,1-dioxy-1λ 6 -thietan-3-yl)oxy]-1H-pyrazole-5-carboxamide, the structural formula of which is shown below:

[0014]

[0015] Excessive pesticide use can easily lead to pest resistance, rendering pesticide applications ineffective. Among them, amide insecticides have emerged as a new, highly effective insecticide for controlling major pests such as the rice stem borer, rice leaf roller, and diamondback moth on crops like rice and vegetables in recent years. Their high efficacy, low toxicity, and low dosage have made them highly sought after since their introduction into the Chinese market. However, due to years of heavy use, various pests in Jiangsu, Jiangxi, Hunan, Guangdong, and Yunnan have developed a degree of resistance to amide insecticides. Summary of the Invention

[0016] In order to solve the above-mentioned problems existing in the prior art, the present invention rationally compounds the compound represented by Formula I with the amide insecticides tolfenpyrad, cyhalodiamide, tetrachlorantraniliprole, piperflanilide, tiorantraniliprole, and pioxaniliprole to provide an insecticidal composition containing amide insecticides. The insecticidal composition has excellent control effects on plant pests, obvious synergistic effects, reduces the dosage of pesticides, and significantly slows the development of pest resistance.

[0017] In order to achieve the above object, the present invention adopts the following technical solution: an insecticidal composition containing an amide insecticide, wherein the active ingredients of the insecticidal composition include active ingredient A and active ingredient B, and the active ingredient A is a compound represented by formula I:

[0018] The active ingredient B is an amide insecticide, and the amide insecticide is any one of tolfenpyrad, cyhalodiamide, tetrachlorantraniliprole, piperflanilide, tiorantraniliprole, and pioxaniliprole; the mass ratio of the active ingredient A to the active ingredient B is 1:40 to 40:1, or any value within the above numerical range.

[0019] Furthermore, the active ingredient B is tolfenpyrad, and the mass ratio of the active ingredient A to the active ingredient B is 1:27 to 32:1, or any value within the above numerical range;

[0020] The active ingredient B is cyhalodiamide, and the mass ratio of the active ingredient A to the active ingredient B is 1:23 to 28:1, or any value within the above numerical range;

[0021] The active ingredient B is tetrachlorantraniliprole, and the mass ratio of the active ingredient A to the active ingredient B is 1:35 to 32:1, or any value within the above numerical range;

[0022] The active ingredient B is piperflanilide, and the mass ratio of the active ingredient A to the active ingredient B is 1:20 to 24:1, or any value within the above numerical range;

[0023] The active ingredient B is tiorantraniliprole, and the mass ratio of the active ingredient A to the active ingredient B is 1:22 to 32:1, or any value within the above numerical range;

[0024] The active ingredient B is pioxaniliprole, and the mass ratio of the active ingredient A to the active ingredient B is 1:25 to 32:1, or any value within the above numerical range.

[0025] Furthermore, the active ingredient B is tolfenpyrad, and the mass ratio of the active ingredient A to the active ingredient B is 1:18 to 16:1, or any value within the above numerical range;

[0026] The active ingredient B is cyhalodiamide, and the mass ratio of the active ingredient A to the active ingredient B is 1:15 to 20:1, or any value within the above numerical range;

[0027] The active ingredient B is tetrachlorantraniliprole, and the mass ratio of the active ingredient A to the active ingredient B is 1:28 to 16:1, or any value within the above numerical range;

[0028] The active ingredient B is piperflanilide, and the mass ratio of the active ingredient A to the active ingredient B is 1:12 to 24:1, or any value within the above numerical range;

[0029] The active ingredient B is tiorantraniliprole, and the mass ratio of the active ingredient A to the active ingredient B is 1:18 to 25:1, or any value within the above numerical range;

[0030] The active ingredient B is pioxaniliprole, and the mass ratio of the active ingredient A to the active ingredient B is 1:15 to 32:1, or any value within the above numerical range.

[0031] Furthermore, the active ingredient B is tolfenpyrad, and the mass ratio of the active ingredient A to the active ingredient B is 1:9 to 8:1, or any value within the above numerical range;

[0032] The active ingredient B is cyhalodiamide, and the mass ratio of the active ingredient A to the active ingredient B is 1:15 to 10:1, or any value within the above numerical range;

[0033] The active ingredient B is tetrachlorantraniliprole, and the mass ratio of the active ingredient A to the active ingredient B is 1:16 to 8:1, or any value within the above numerical range;

[0034] The active ingredient B is piperflanilide, and the mass ratio of the active ingredient A to the active ingredient B is 1:10 to 16:1, or any value within the above numerical range;

[0035] The active ingredient B is tiorantraniliprole, and the mass ratio of the active ingredient A to the active ingredient B is 1:18 to 14:1, or any value within the above numerical range;

[0036] The active ingredient B is pioxaniliprole, and the mass ratio of the active ingredient A to the active ingredient B is 1:15 to 24:1, or any value within the above numerical range.

[0037] Furthermore, in addition to the active ingredients, the insecticide composition also includes other pesticide-acceptable adjuvants, and the adjuvants are selected from one or more of dispersants, wetting agents, emulsifiers, stabilizers, antifreeze agents, defoaming agents, preservatives, thickeners, solvents, organic acids, and dispersion media.

[0038] Furthermore, the formulation of the insecticide composition is one or more of emulsifiable concentrate, microemulsion, soluble liquid, suspension, aqueous solution, aqueous emulsion, ultra-low volume liquid, dispersible oil suspension, water-dispersible granules or wettable powder.

[0039] The invention also discloses the use of the insecticide composition in preventing and controlling plant pests.

[0040] Furthermore, the insecticidal composition of the present invention has a significant synergistic effect on the following lepidopteran pests: Plutella xylostella, diamondback moth, Polychrosis viteana (grape berry moth), Prays endocarpa, Prays oleae (olive moth), Pseudaletia spp. (southworms), Pseudaletia unipunctata (armyworm), Pseudoplusia includes (soybean looper), Rachiplusia nu, Scirpophaga incertulas, Sesamia spp. (stemborers), Sesamia inferens (pink ricestemworm), and Pseudaletia spp. (southworms). borer), Sesamia nonagrioides, Setora nitens, Sitotroga cerealella (Angoumois grain moth), Sparganothis pilleriana, Spodoptera spp. (snodocleaf moth), Spodoptera exigua (beet armyworm), Spodoptera fugiperda (fall armyworm), Adoxophyes spp., Adoxophyes orana, Agrotis spp.(cutworm), Agrotis ipsilon (black cutworm), Alabama argillacea, Amorbia cuneana, Amyelosis transitella (navel orangeworm), Anarsia lineatella (peach twig borer), Anomis sabulifera (jute looper), Anticarsia gemma talis (velvet bean piller), Archips argyrospila (fruittree leaf roller), Archips rosana (rose leaf roller), Argyrotaenia spp. (tortricid moths), Argyrotaenia citrana, Autographa gamma, Bonagota cranaodes, Borbo cinnara, Caloptilia spp. (leaf miners), Capua reticulana, Carposina niponensis (peach fruit moth), Chilo spp., Chlumetia transversa (mango shoot borer), Choristoneura rosaceana (obliquebanded leafroller), Chrysodeixis spp., Cnaphalocerus medinalis (grass leafroller), Colias spp., Conpomorpha cramerella, Cossus cossus, Crambus spp.) (Sod webworms), Cydia funebrana (plum fruit moth), Cydia molesta (oriental fruit moth), Cydia nignicana (pea moth), Cydia pomonella, Darna diducta, Diaphania spp. (stem borers), Diatraea spp. (stalk borers), Diatraea saccharalis (sugarcane borer), Diatraea graniosella (southwester corn borer), Earias spp. (cotton bollworms), Earias spp. (Egyptian bollworms). insulata (Egyptian bollworm), Earias vitella (rough northern bollworm), Ecdytopopha aurantianum, Elasmopalpus lignosellus (lesser cornstalk borer), Ephestia spp. (flour moths), Ephestia cautella (almond moth), Ephestia elutella (tobbaco moth), Ephestia kuehniella (Mediterranean flour moth), Epimeces spp., Epinotia aporema, Erionota thrax (banana skipper), Eupoecilia ambiguella), Euxoaauxiliaris (army cutworm), Feltia spp., Gortyna spp.(stemborers), Grapholita molesta (oriental fruit moth), Hedylepta indicate, bean leafwebber, Helicoverpa sp p. (spotworms), Helicoverpa paarmigera, Helicoverpa zea, Heliothis spp. (spotworms), Heliothis virescens, tobacco budworm, Hellula undalis (cabbage webworm), Indarbela spp., root borers, Keiferia lycopersicella, (tomato pinworm, Leucino desorbonalis (eggplant fruit borer) borer), Leucoptera malifoliella, Lithocollectis spp., Lobesia botrana (grape fruitmoth), Loxagrotis spp. (southworms), Loxagrotis albicosta (western bean cutworm), Lymantria dispar (gypsy moth), Lyonetia clerkella (apple leaf miner), Mahasena corbetti (oil palm bagworm), Malacosoma spp.(tent caterpillars), Mamestra brassicae (cabbage armyworm), Maruca testulalis, Metisa plana, Mythimna unipuncta (true armyworm), Neoleucinodes elegantalis (small tomato borer), Operophthera brumata (winter moth), Ostrinia nubilalis (European corn borer), Pandemiscerasana, common currant tortrix, Pandemis heparana (brown apple tortrix), Papilio demodocus, Pectinophoragossypiella (pink bollworm), Peridroma species ( spp. (cutworm), Peridroma saucia (variegated cutworm), Perileucoptera coffeella (white coffee leafminer), Phthorimaea operculella (potato tuber moth), Phyllocnisitis citrella, Phyllonorycter spp. (leafminers), Pieris rapae (imported cabbageworm), Plathypena scabra, Plodia interpunctella (Indian meal moth), Spodoptera oridania (southern armyworm), Synanthedon spp.) (root borers), Thecla basilides, Thermisia gemmatalis, Tineola bisselliella (webbing clothes moth), Trichoplusia ni (rape worm), Tuta absoluta, Yponomeuta spp., Zeuzera coffeae (redbranch borer), and Zeuzera pyrina (leopard moth).

[0041] In particular, the insecticide composition of the present invention has obvious synergistic effects on lepidopteran pests such as cotton bollworm, Spodoptera litura, rice borer, diamondback moth and cabbage worm, and has excellent control effects.

[0042] Furthermore, the insecticide composition is applied to the pests and the medium where the pests occur.

[0043] In order to obtain the desired insecticidal effect, the dosage of the insecticidal composition varies depending on various factors, such as the crop to be protected, the type of pest, the degree of infection, climatic conditions, application site, application method, dosage form used, etc.

[0044] The beneficial effects of the present invention are as follows:

[0045] 1) The present invention rationally compounds insecticide compositions with different action mechanisms, greatly improving the insecticidal effect of amide insecticides, with significant synergistic effects, increasing the utilization rate of the pesticides, and reducing environmental pollution;

[0046] 2) The insecticide composition of the present invention can significantly delay the development of insecticide resistance, reduce production costs, and extend the service life of a single agent. DETAILED DESCRIPTION

[0047] In order to make the technical solutions, objectives and advantages of the present invention more clearly understood, the present invention is described with reference to the following specific embodiments. However, the present invention can be implemented in various forms and should not be limited to the embodiments described herein.

[0048] Preparation example:

[0049] Preparation Example 1: 20% Formula I compound·Tolfenpyrad suspension (1:9)

[0050] Formula: 2% compound of formula I, 18% tolfenpyrad, 2% sodium lauryl sulfate, 3% sorbitan oleate polyoxyethylene ether, 4% tristyrylphenol ethoxylate phosphate, 0.25% xanthan gum, 1% magnesium aluminum silicate, 5% glycerol, 0.01% potassium benzoate, 0.5% silicone oil, and deionized water to make up the balance;

[0051] Preparation method: According to the formula ratio, the active ingredients, surfactants and other functional additives are placed in a reactor in sequence, water is added and mixed evenly, and the suspension product is obtained by high-speed shearing, wet sand grinding, and finally homogenization filtration.

[0052] Preparation Example 2: 25% Formula I compound·Tolfenpyrad water dispersible granules (2:3)

[0053] Formula: 10% compound of formula I, 15% tolfenpyrad, 6% lignin sulfonate, 6% sodium alkyl polyoxyethylene ether sulfonate, 3% sodium lauryl sulfate, 5% white carbon black, 25% starch, and kaolin makes up the balance;

[0054] Preparation method: According to the proportions in the example, the active ingredient is added to the carrier, and a surfactant and other functional additives are added thereto, mixed, and after air flow grinding, 10-25% water is added, and then the mixture is kneaded, granulated, dried, and sieved to obtain a water-dispersible granule product; or the pulverized powder is sprayed with water in a boiling granulator, granulated, dried, and then sieved to obtain the product.

[0055] Preparation Example 3: 18% Formula I compound·Tolfenpyrad emulsifiable concentrate (7:2)

[0056] Formula: 14% compound of formula I, 4% tolfenpyrad, 2% antioxidant BHT, 15% DMF, 12% castor oil polyoxyethylene ether, 2% calcium dodecylbenzenesulfonate, 20% propylene carbonate, and xylene makes up the balance;

[0057] Preparation method: According to the formula ratio, the measured active ingredients, solvent and cosolvent are added to a mixing kettle and stirred to dissolve them, then the emulsifier is added and the balance is supplemented with the remaining solvent, and the mixture is stirred evenly in a stirring kettle. After filtering, the desired emulsifiable concentrate of the present invention is obtained.

[0058] Preparation Example 4: 4.5% Formula I compound·Tolfenpyrad microemulsion (8:1)

[0059] Formula: 4% compound of formula I, 0.5% tolfenpyrad, 2% antioxidant BHT, 15% xylene, 20% cyclohexanone, 12% tristyrylphenol polyoxyethylene ether polyoxypropylene ether, 6% EO-PO block copolymer, 2% fatty alcohol polyoxyethylene ether sulfate, 5% propylene glycol, 0.15% silicone defoamer, and deionized water to make up the balance;

[0060] Preparation method: After completely dissolving the active ingredient in the solvent according to the formula ratio, add an emulsifier to make an oil phase, add a dispersant, deionized water, etc. and stir evenly to make an aqueous phase; add the oil phase to the aqueous phase and stir evenly, shear at high speed until the particle size meets the requirements, add a defoaming agent and stir evenly to obtain the microemulsion product.

[0061] Preparation Example 5: 16% Formula I compound·Cyfluanid dispersible oil suspension (1:15)

[0062] Formula: 1% compound of formula I, 15% chlorfluanid, 2% naphthalenesulfonate formaldehyde condensate, 3% Guerbet alcohol polyoxyethylene ether, 10% triphenol polyoxyethylene ether, 3% ethylene glycol oxyethylene polyoxypropylene ether, 2% calcium dodecylbenzenesulfonate, 1% silicon dioxide, 1% organobentonite, and methyl oleate makes up the balance;

[0063] Preparation method: According to the formula ratio, the active ingredients, surfactants and other functional additives are placed in the reactor in sequence, oil is added and mixed evenly, and the dispersible oil suspension product is obtained by high-speed shearing, wet sand grinding, and finally homogenization filtration.

[0064] Preparation Example 6: 24% Formula I compound·Cyfluanid suspension concentrate (2:1)

[0065] Formula: 16% compound of formula I, 8% chlorfluanid, 1% alkylaryl polyoxyethylene ether polyoxypropylene ether, 5% tristyrylphenol ethoxylate phosphate, 1% sodium lignin sulfonate, 3% sodium octylphenol polyoxyethylene ether sulfonate, 0.25% xanthan gum, 5% ethylene glycol, 0.1% sodium sorbate, 0.5% silicone oil, and deionized water to make up the balance;

[0066] Preparation method: Same as Preparation Example 1.

[0067] Preparation Example 7: 24% Formula I compound·Cyfluanid water dispersible granules (5:1)

[0068] Formula: 20% compound of formula I, 4% chlorfluanid, 8% succinate sulfonate, 2% lakai powder BX, 5% sodium polycarboxylate, 3% white sugar, and kaolin to make up the balance;

[0069] Preparation method: same as Preparation Example 2.

[0070] Preparation Example 8: 33% Formula I compound·Cyfluanid wettable powder (10:1)

[0071] Formula: 30% compound of formula I, 3% chlorfluanid, 3% fatty alcohol ethylene oxide-propylene oxide copolymer, 6% sodium lignin sulfonate, 10% dispersant NNO, 2% opening powder BX, 6% white carbon black, and kaolin to make up the balance;

[0072] Preparation method: The active ingredients, dispersant, wetting agent and filler are mixed according to the formula ratio, stirred evenly in a stirring kettle, and pulverized and mixed evenly for multiple times in a jet mill to prepare the wettable powder of the composition of the present invention.

[0073] Preparation Example 9: 27% Formula I compound·tetrachlorantraniliprole suspension (1:1)

[0074] Formula: 13.5% compound of formula I, 13.5% tetrachlorantraniliprole, 2% isomeric tridecanol polyoxyethylene ether, 2% ethylene glycol oxyethylene polyoxypropylene ether, 3% styrenated phenol polyoxyethylene ether sulfate, 1% sodium salt of polycarboxylate, 1.5% magnesium aluminum silicate, 0.1% carboxyethyl cellulose, 1% kasonide, 5% ethylene glycol, 0.25% silicone oil, and deionized water to make up the balance;

[0075] Preparation method: Same as Preparation Example 1.

[0076] Preparation Example 10: 35% Formula I compound·tetrachlorantraniliprole water dispersible granules (1:4)

[0077] Formula: 7% compound of formula I, 28% tetrachlorantraniliprole, 3% sodium salt of polycarboxylate, 4% naphthalenesulfonate formaldehyde condensate, 12% calcium ligninsulfonate, 2% fatty alcohol polyoxyethylene ether sulfate, 10% ammonium sulfate, and starch makes up the balance.

[0078] Preparation method: same as Preparation Example 2.

[0079] Preparation Example 11: 18% Formula I compound·tetrachlorantraniliprole dispersible oil suspension (8:1)

[0080] Formula: 16% compound of formula I, 2% tetrachlorantraniliprole, 5% sorbitan oleate polyoxyethylene ether, 8% castor oil polyoxyethylene ether, 2% calcium dodecylbenzenesulfonate, 2% sodium polycarboxylate, 1% organic bentonite, and soybean oil makes up the balance;

[0081] Preparation method: Same as Preparation Example 3.

[0082] Preparation Example 12: 21% Formula I compound·polyflubendiamide suspension (1:6)

[0083] Formula: 3% compound of formula I, 18% polyflubenzuronide, 2% ethylene glycol oxyethylene polyoxypropylene ether, 1% naphthalenesulfonate formaldehyde condensate, 3% tristyrylphenol ethoxylate phosphate, 3% castor oil polyoxyethylene ether, 0.2% xanthan gum, 1% magnesium aluminum silicate, 5% ethylene glycol, 0.2% sodium benzoate, 0.5% silicone oil, and deionized water to make up the balance;

[0084] Preparation method: Same as Preparation Example 1.

[0085] Preparation Example 13: 20% Formula I compound·polyflubendiamide water dispersible granules (3:2)

[0086] Formula: 12% compound of formula I, 8% polyflubenzuronide, 3% wetting agent EFW, 7% naphthalenesulfonate formaldehyde condensate, 5% sodium alkyl polyoxyethylene ether sulfonate, 5% white carbon black, 20% starch, and kaolin makes up the balance;

[0087] Preparation method: same as Preparation Example 2.

[0088] Preparation Example 14: 30% Formula I compound·polyflubendiamide wettable powder (5:1)

[0089] Formula: 25% compound of formula I, 5% polyflubenzuronide, 2% sodium lauryl sulfate, 5% styrenated phenol polyoxyethylene ether sulfate, 5% tea saponin, 2% sodium alginate, 10% light calcium carbonate, and kaolin makes up the balance;

[0090] Preparation method: Same as Preparation Example 8.

[0091] Preparation Example 15: 22% Formula I compound·sulfinamide suspension (1:10)

[0092] Formula: 2% compound of formula I, 20% thiobenzamide, 5% tristyrylphenol polyoxyethylene ether polyoxypropylene ether, 5% arylphenol polyoxyethylene ether phosphate, 2% sodium polycarboxylate, 0.25% xanthan gum, 5% propylene glycol, 0.1% sodium benzoate, 0.5% silicone oil, and deionized water to make up the balance;

[0093] Preparation method: Same as Preparation Example 1.

[0094] Preparation Example 16: 35% Formula I compound·sulfuronamide water dispersible granules (5:2)

[0095] Formula: 25% compound of formula I, 10% thiobenzamide, 2% sodium lauryl sulfate, 10% sodium lignin sulfonate, 5% naphthalenesulfonate formaldehyde condensate, 10% ammonium sulfate, and kaolin makes up the balance;

[0096] Preparation method: same as Preparation Example 2.

[0097] Preparation Example 17: 8% Formula I compound·sulfuronamide emulsifiable concentrate (7:1)

[0098] Formula: 7% compound of formula I, 1% thiobenzamide, 15% propylene glycol methyl ether, 10% tristyrylphenol polyoxyethylene ether, 2% calcium dodecylbenzenesulfonate, 15% DMF, 18% cyclohexanone, and methyl oleate makes up the balance;

[0099] Preparation method: according to the formula ratio, the active ingredient, solvent and cosolvent are added to the mixing kettle and stirred to dissolve, then the emulsifier is added and the balance is supplemented with the remaining solvent, and the mixture is stirred evenly in the stirring kettle and filtered to obtain the desired emulsifiable concentrate of the present invention.

[0100] Preparation Example 18: 22% Formula I compound·Thiocyclam suspension (5:6)

[0101] Formula: 10% compound of formula I, 12% thiocyclotetramid, 6% glycerol fatty acid ester polyoxyethylene ether, 5% tristyrylphenol ethoxylate phosphate, 2% naphthalenesulfonate, 0.25% xanthan gum, 5% glycerol, 0.15% sodium sorbate, 0.5% silicone oil, and deionized water to make up the balance;

[0102] Preparation method: Same as Preparation Example 1.

[0103] Preparation Example 19: 30% Formula I compound·Thiocyclam water dispersible granules (1:4)

[0104] Formula: 6% compound of formula I, 24% thiocyclopentadienil, 2% sodium lauryl sulfate, 8% naphthalenesulfonate formaldehyde condensate, 6% sodium salt of polycarboxylate, 8% ammonium sulfate, and kaolin makes up the balance;

[0105] Preparation method: same as Preparation Example 2.

[0106] Preparation Example 20: 8% Formula I compound·Thiocyclamide emulsifiable concentrate (7:1)

[0107] Formula: 7% compound of formula I, 1% thiobenzamide, 15% propylene glycol methyl ether, 10% polyoxyethylene oleate, 2% calcium dodecylbenzenesulfonate, 12% DMF, 20% cyclohexanone, and methyl oleate makes up the balance;

[0108] Preparation method: according to the formula ratio, the active ingredient, solvent and cosolvent are added to the mixing kettle and stirred to dissolve, then the emulsifier is added and the balance is supplemented with the remaining solvent, and the mixture is stirred evenly in the stirring kettle and filtered to obtain the desired emulsifiable concentrate of the present invention.

[0109] Indoor biological activity test:

[0110] Example 1: Indoor biological activity test of the composite composition against rice stem borer

[0111] Test basis: The test refers to NY / T 1154.10-2008 "Guidelines for Indoor Bioassay Tests of Pesticides - Insecticides Part 10: Artificial Diet Mixture Method".

[0112] Biological test materials: Rice stem borer, third-instar larvae that were continuously reared indoors and had consistent physiological states were selected.

[0113] Test agents: tolfenpyrad, chlorfluanid, tetrachloranid, polyfluanid, thiobencarb, thiocyclanil, and the technical drug of the compound of formula I.

[0114] Preparation of pharmaceutical preparation: Dissolve the above raw materials in a suitable organic solvent to prepare a mother solution, and use Tween-80 aqueous solution to prepare 5 series of mass concentrations according to the equal ratio method.

[0115] Test method: Evenly mix an appropriate amount of diluted drug solution into the prepared artificial feed, pour it into 12-well plates while it is hot and cool it down, then inoculate one test insect into each well. Repeat each treatment 4 times, with 20 test insects per repetition, and set a treatment without drug (containing organic solvents) as a blank control.

[0116] Rearing and Observation: Treated test insects were housed and observed at a temperature of (25 ± 1)°C, a relative humidity of 60% to 80%, and a photoperiod of L:D = (16:8) h. Forty-eight hours after treatment, the insects were examined for mortality, and the total number of insects and the number of dead insects were recorded.

[0117] Calculation method:

[0118] Based on the survey data, the mortality rate of each treatment was calculated.

[0119] Calculate as follows:

[0120]

[0121] Where:

[0122] P——mortality rate, in percentage (%);

[0123] K——indicates the number of dead insects, the unit is head;

[0124] N——represents the total number of insects processed, in heads.

[0125]

[0126] Where:

[0127] P1——adjusted mortality rate, in percentage (%);

[0128] P t ——Treatment mortality rate, expressed in percentage (%);

[0129] P0 - blank control mortality rate, in percentage (%).

[0130] If the control mortality rate is less than 5%, no correction is required; if the control mortality rate is between 5% and 20%, correction should be made according to the correction mortality formula; if the control mortality rate is greater than 20%, the test needs to be repeated.

[0131] The DPS statistical analysis system was used to analyze the toxicity regression equation, correlation coefficient and LC 50 The activity of the test agent on the biological test material is evaluated by the value.

[0132] The co-toxicity coefficient (CTC value) of the mixture is calculated as follows:

[0133]

[0134] Where:

[0135] ATI - measured toxicity index of mixture;

[0136] S——LC of standard pesticide 50 , the unit is milligrams per liter (mg / L);

[0137] M——LC of the mixture 50 , the unit is milligrams per liter (mg / L).

[0138] TTI=TI A ×P A +TI B ×P B

[0139] Where:

[0140] TTI – Theoretical Toxicity Index of Mixtures;

[0141] TI A ——Agent toxicity index;

[0142] P A ——The percentage of agent A in the mixture, in percentage (%);

[0143] TI B ——Toxicity index of agent B;

[0144] P B ——The percentage of agent B in the mixture, in percentage (%).

[0145]

[0146] Where:

[0147] CTC – Co-toxicity coefficient;

[0148] ATI - measured toxicity index of mixture;

[0149] TTI - Theoretical Toxicity Index of Mixture.

[0150] A co-toxicity coefficient (CTC) of 120 or higher indicates a synergistic effect; a co-toxicity coefficient (CTC) of 80 or lower indicates an antagonistic effect; and a co-toxicity coefficient (CTC) of 80 or lower indicates an additive effect.

[0151] The indoor test results are shown in the table below:

[0152] Table 1 Results of indoor biological activity test of compound of formula I and tolfenpyrad against Chilo suppressalis

[0153]

[0154] As shown in the indoor biological activity test results in Table 1, the compound of Formula I and tolfenpyrad, when combined at appropriate mass ratios, exhibited excellent control effects against the rice stem borer. When the mass ratio of the compound of Formula I to tolfenpyrad was 1:27 to 32:1, the co-toxicity coefficient against the rice stem borer was greater than 120, demonstrating a synergistic effect. When the mass ratio of the compound of Formula I to tolfenpyrad was 1:18 to 16:1, the co-toxicity coefficient was greater than 130, indicating a significant synergistic effect. When the mass ratio of the compound of Formula I to tolfenpyrad was 1:9 to 8:1, the co-toxicity coefficient was greater than 140, indicating a significant synergistic effect.

[0155] Table 2 Indoor biological activity test results of compound I and cyfluthrin against Chilo suppressalis

[0156]

[0157] As shown in the indoor bioassay results in Table 2, the compound of Formula I and cyfluthrin, when combined in appropriate mass ratios, exhibited excellent control effects against the rice stem borer. When the mass ratio of the compound of Formula I to cyfluthrin was 1:23 to 28:1, the co-toxicity coefficient against the rice stem borer was greater than 120, demonstrating a synergistic effect. When the mass ratio of the compound of Formula I to cyfluthrin was 1:15 to 20:1, the co-toxicity coefficient was greater than 130, indicating a significant synergistic effect. When the mass ratio of the compound of Formula I to cyfluthrin was 1:15 to 10:1, the co-toxicity coefficient was greater than 140, indicating a significant synergistic effect.

[0158] Table 3 Indoor biological activity test results of compound I and tetrachlorantraniliprole against Chilo suppressalis

[0159]

[0160] As shown in the indoor biological test results in Table 3, the compound of Formula I and tetrachlorantraniliprole, when combined in appropriate mass ratios, exhibited excellent control effects against the rice stem borer. When the mass ratio of the compound of Formula I to tetrachlorantraniliprole was 1:35 to 32:1, the co-toxicity coefficient against the rice stem borer was greater than 120, demonstrating a synergistic effect. When the mass ratio of the compound of Formula I to tetrachlorantraniliprole was 1:28 to 16:1, the co-toxicity coefficient against the rice stem borer was greater than 130, demonstrating a significant synergistic effect. When the mass ratio of the compound of Formula I to tetrachlorantraniliprole was 1:16 to 8:1, the co-toxicity coefficient against the rice stem borer was greater than 140, demonstrating a significant synergistic effect.

[0161] Table 4 Indoor biological activity test results of compound of formula I and polyflubendiamide against rice stem borer

[0162]

[0163] As shown in the indoor biological test results in Table 4, the compound of Formula I and polyflubendiamide, when combined in an appropriate mass ratio, exhibited excellent control effects against the rice stem borer. When the mass ratio of the compound of Formula I to polyflubendiamide was 1:20 to 24:1, the co-toxicity coefficient was greater than 120, indicating a synergistic effect. When the mass ratio of the compound of Formula I to polyflubendiamide was 1:12 to 24:1, the co-toxicity coefficient was greater than 130, indicating a significant synergistic effect. When the mass ratio of the compound of Formula I to polyflubendiamide was 1:10 to 16:1, the co-toxicity coefficient was greater than 140, indicating a significant synergistic effect.

[0164] Table 5 Indoor biological activity test results of compound of formula I and thiocarbamide against Chilo suppressalis

[0165]

[0166] As shown in the indoor biological test results in Table 5, the compound of Formula I and thiobencarb, when combined at appropriate mass ratios, exhibited excellent control effects against the rice stem borer. The mass ratio of the compound of Formula I to thiobencarb was 1:22 to 32:1, with a co-toxicity coefficient greater than 120, demonstrating a synergistic effect against the rice stem borer. The mass ratio of the compound of Formula I to thiobencarb was 1:18 to 25:1, with a co-toxicity coefficient greater than 130, indicating a significant synergistic effect. The mass ratio of the compound of Formula I to thiobencarb was 1:18 to 14:1, with a co-toxicity coefficient greater than 140, indicating a significant synergistic effect.

[0167] Table 6 Indoor biological activity test results of compound I combined with thiophanate against Chilo suppressalis

[0168]

[0169] As shown in the indoor biological activity test results in Table 6, the compound of Formula I and thiocyclamide, when combined in an appropriate mass ratio, exhibited excellent control efficacy against the rice stem borer. When the mass ratio of the compound of Formula I to thiocyclamide was 1:25 to 32:1, the co-toxicity coefficient against the rice stem borer was greater than 120, demonstrating a synergistic effect. When the mass ratio of the compound of Formula I to thiocyclamide was 1:15 to 32:1, the co-toxicity coefficient was greater than 130, indicating a significant synergistic effect. When the mass ratio of the compound of Formula I to thiocyclamide was 1:15 to 24:1, the co-toxicity coefficient was greater than 140, indicating a significant synergistic effect.

[0170] Example 2: Field efficacy test for controlling rice stem borer

[0171] Experimental area: Qinghe Village, Jingkou Township, Nanchang County, Nanchang City, Jiangxi Province. Rice is planted all year round in the experimental field. The experimental object is rice stem borer. The rice variety is Huanghuazhan. The experimental field has convenient irrigation and drainage and medium soil fertility.

[0172] Experimental method: The experiment set up 14 treatments, 13 of which were pesticide treatments. Water spraying was used as a blank control. Each treatment was repeated 4 times. The plots were arranged in random groups. Each plot had an area of ​​50m2. 2 0.5m isolation zones were set up between plots. The pesticide was applied during the peak hatching period of the Chilo suppressalis eggs, with no rainfall on the day of application and 3 days afterward. According to the concentration requirements for different pesticides, the weighed pesticides for each test plot were first mixed evenly in a small amount of water, then diluted to the desired concentration in each plot. After diluting the pesticide, a 3WBD-18 backpack electric sprayer was used to add 600L / hm2 of water. 2 The rice plants were then sprayed evenly with the pesticide once, while the control plot was sprayed with an equal amount of water. No other pesticides were applied during the experiment, and all other agricultural operations were managed according to normal production methods.

[0173] Experimental investigation: 21 days after the application of the pesticide, parallel jumping sampling was carried out at 5 points in each plot. 5 rice clumps were surveyed in each plot to investigate the number of dead hearts and the total number of plants.

[0174] Calculation method of drug efficacy:

[0175]

[0176] The results of the field efficacy test are shown in the following table:

[0177] Table 7 Results of field efficacy tests on control of rice stem borer

[0178]

[0179] Safety investigation: During the field trial, no pesticide damage occurred in any treatment group, and no adverse effects were found on the surrounding environment and other beneficial organisms in the test area, indicating that the test agents were safe for rice growth at the doses provided.

[0180] The results showed (see Table 7) that the combination preparations were significantly better than other agents in terms of both rapid and long-lasting effectiveness in controlling the rice stem borer. The 22% Formula I compound·thiocyclam suspension concentrate (5:6) had the highest control efficacy of 96.00%.

[0181] Example 3: Field efficacy test for controlling fall armyworm

[0182] The test site is the corn field in Juyang Village, Gongji Town, Taihe County, Fuyang City, Anhui Province. The soil of the experimental field is sandy loam, the ground is flat, the soil fertility is medium, and the drainage and irrigation are convenient. The corn planting spacing is 20 cm, and one corn is sown in a hole. The planting management is the same as the local corn planting management.

[0183] Experimental design: The experiment was arranged in random blocks, with a total of 14 treatments, 4 replicates per treatment, and a plot area of ​​45m 2 .

[0184] Test method: The corn was in the bell-opening stage when the test began. The pesticides were applied according to the test design using a backpack sprayer. The pesticide application rate was the amount of active ingredient. The water consumption for each treatment was 450L / hm2. 2 The cultivation and water and fertilizer management conditions in all experimental plots were uniform and consistent.

[0185] Experimental investigation: Diagonal sampling method was used for investigation. Five points were investigated in each plot, with 20 plants at each point, for a total of 100 plants. All investigated plants were marked. The insect population base was investigated before spraying. The number of live insects was investigated 3, 7, and 14 days after spraying. The insect population reduction rate and control effect were calculated according to the following formula.

[0186] Calculation method of drug efficacy:

[0187]

[0188]

[0189] The results of the field efficacy test are shown in the table below:

[0190] Table 8 Results of field efficacy tests on fall armyworm

[0191]

[0192] The results of the field efficacy test show that the insecticide composition of the present invention has a good control effect on fall armyworm. Preparation Example 7: 24% Formula I compound·Cyclofluanid water dispersible granules (5:1), Preparation Example 14: 30% Formula I compound·Diofluanid wettable powder (5:1), Preparation Example 2: 25% Formula I compound·Tolfenpyrad water dispersible granules (2:3), Preparation Example 20: 8% Formula I compound·Sulfluanid emulsifiable concentrate (7:1), Preparation Example 17: 8% Formula I compound·Sulfluanid emulsifiable concentrate (7:1), Preparation Example 9 : The control effects of 27% formula I compound·tetrachlorantraniliprole suspension concentrate (1:1) were 82.90%, 87.89%, 85.51%, 89.12%, 86.42% and 90.62% respectively 3 days after application, showing good quick-acting property; 14 days after application, the efficacy of each compound preparation was 90.05%, 90.23%, 87.52%, 93.22%, 93.23% and 96.61%, with a long lasting effect.

[0193] In summary, through indoor toxicity assays and field efficacy tests, it can be seen that the insecticidal composition of the present invention has a good control effect on lepidopteran pests, is safe for target crops, has significant control effects, and is superior to a single agent in delaying the development of drug resistance and prolonging the duration of effect.

[0194] Although the present application describes specific embodiments in detail by way of example, the disclosure of the present application may adopt various modifications and alternative forms. However, it should be understood that the disclosure of the present application is not limited to the specific forms disclosed. On the contrary, the disclosure of the present application covers all modifications, equivalents and alternative forms within the scope of the disclosure of the present application, and the scope of the present application is limited by the appended claims and their legal equivalents.

Claims

1. Use of an insecticide composition containing an amide insecticide in controlling plant pests, characterized in that: The active ingredients of the insecticide composition include active ingredient A and active ingredient B, wherein the active ingredient A is a compound represented by formula I: (Formula I), the active ingredient B is an amide insecticide, and the amide insecticide is tolfenpyrad; the mass ratio of the active ingredient A to the active ingredient B is 1:9 to 8:1, and the pest is the rice stem borer.

2. The use according to claim 1, characterized in that In addition to the active ingredients, the insecticide composition also includes other pesticide-acceptable adjuvants, which are selected from one or more of dispersants, wetting agents, emulsifiers, stabilizers, antifreeze agents, defoaming agents, preservatives, thickeners, solvents, organic acids, and dispersion media.

3. The use according to claim 1, characterized in that The preparation form of the insecticide composition is one or more of emulsifiable concentrate, microemulsion, soluble liquid, suspension, aqueous solution, aqueous emulsion, ultra-low volume liquid, dispersible oil suspension, water-dispersible granules or wettable powder.

4. The use according to claim 1, characterized in that The insecticide composition is applied to pests and media where the pests occur.

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