Sodium colanate repair dressing for post-care of light medical aesthetics and preparation method thereof

Abstract

The present invention provides a dressing, a preparation method, and uses thereof. The dressing comprises a base material and a composition, wherein the composition comprises a sodium colanate, a coagulant, a dispersant, water, and optionally a pH adjuster and an optional preservative. A scientifically formulated composition improves the film-forming effect of the dressing, shortens the film-forming time, and ensures its physical barrier function. A steam pretreatment process is employed during the preparation process to reduce the bacterial endotoxins and pyrogens in the sodium colanate raw material. The dressing is used for post-operative care after light medical aesthetics and has strong moisturizing and soothing effects, a physical barrier effect, and promotes wound healing.

Description

Technical Field

[0001] The invention relates to the technical field of medical dressings, and in particular to a sodium colanate repair dressing and a preparation method thereof. Background Art

[0002] In recent years, light cosmetic surgery has become a rapidly growing new force in the medical aesthetics field, gradually gaining a dominant position in the market. Compared to traditional surgical cosmetic procedures, light cosmetic surgery offers minimal invasiveness, low risk, rapid recovery, and natural-looking results. Light cosmetic procedures, such as laser, radiofrequency, ultrasound, injections, and chemical peels, primarily target the surface layer of the skin or the basal layer of the dermis to achieve rejuvenation, firming, scar repair, and anti-aging effects. However, while light cosmetic surgery is less invasive, it inevitably causes some damage to the skin barrier. On the one hand, light cosmetic surgery may cause discomfort such as redness, swelling, heat, and pain. On the other hand, the damage to the skin barrier caused by light cosmetic surgery, if not properly managed, can lead to problems such as scaling, acne, infection, and hyperpigmentation, causing harm to the patient. Regardless of the type of light cosmetic surgery, timely post-operative care is crucial to minimize post-operative discomfort, repair the skin barrier, reduce complications, and maximize post-operative results. In addition to simple cleaning, sun protection and anti-irritation methods, it is necessary to use some medical repair products for post-treatment care of light medical aesthetics, which can relieve pain, moisturize the skin, and act as a physical barrier to accelerate the healing of wounds.

[0003] Colanic acid (CA) is a high-molecular-weight extracellular capsular polysaccharide secreted by bacteria, also known as claric acid. It is primarily composed of D-glucuronic acid, D-glucose, D-galactose, and L-fucose, with a ratio of approximately 1:2:2:1. It also contains various chemical modifications on its side chains, such as O-acetyl and pyruvic acid. During the subsequent separation and purification process, colanic acid is treated with an alkaline solution, such as its sodium salt, to form the more stable sodium colanate, which can reach a molecular weight exceeding 10 million Daltons. It is impermeable to the skin and difficult to absorb. Sodium colanate is homologous to human moisturizing factors, possessing a porous fibrous structure and numerous hydrophilic groups on its surface, resulting in exceptional moisture retention. Its macromolecular structure also allows for excellent physical film-forming properties, maintaining internal and external moisture balance in the skin, protecting against harmful substances and other irritants, and alleviating redness, swelling, and pain. Furthermore, sodium colanate exhibits excellent biocompatibility and lacks pharmacological effects, making it an ideal post-care material for light medical aesthetics.

[0004] Research on sodium colanate has become a hot topic in recent years. As a novel biomaterial, it holds great potential for application in post-operative care for aesthetic and light medical applications. Current research focuses on bacterial gene modification, efficient bacterial expression, late-stage fermentation or purification processes, and the development of small molecules. However, there are few reports on its application in areas such as post-operative care for aesthetic and light medical applications. Summary of the Invention

[0005] The present invention provides a sodium colanate repair dressing for post-care of light medical aesthetics and a preparation method thereof.

[0006] One aspect of the present disclosure provides a composition comprising a colanate salt, a coagulant, a dispersant, water, and optionally a pH adjuster and an optional preservative.

[0007] According to some embodiments of the present disclosure, the colactic acid salt is sodium colactic acid. In some preferred embodiments, the weight average molecular weight of sodium colactic acid is 400 kDa-8000 kDa.

[0008] According to some embodiments of the present disclosure, the coagulant is one or more selected from carbomer, kaolin and phospholipids.

[0009] According to some preferred embodiments of the present disclosure, the coagulant is carbomer.

[0010] According to some embodiments of the present disclosure, the dispersant is one or more selected from methanol, ethanol, n-propanol, isopropanol, ethyl acetate, n-hexane and polyethylene glycol.

[0011] According to some preferred embodiments of the present disclosure, the dispersant is polyethylene glycol.

[0012] According to some embodiments of the present disclosure, the pH adjuster is one or more selected from citric acid, tartaric acid, citric acid, malic acid, chlorogenic acid, palmitic acid, glacial acetic acid, triethanolamine, sodium hydroxide, potassium hydroxide and tromethamine.

[0013] According to some preferred embodiments of the present disclosure, the pH adjuster is one or more selected from citric acid, tartaric acid, citric acid, malic acid, chlorogenic acid, palmitic acid, glacial acetic acid, triethanolamine, sodium hydroxide, potassium hydroxide and tromethamine.

[0014] According to some preferred embodiments of the present disclosure, the pH adjuster is tromethamine.

[0015] According to some embodiments of the present disclosure, the preservative is one or more selected from sodium benzoate, potassium sorbate, sorbic acid and methylparaben.

[0016] According to some preferred embodiments of the present disclosure, the preservative is methylparaben.

[0017] According to some embodiments of the present disclosure, the composition comprises: water, sodium colanate, carbomer, polyethylene glycol 400, tromethamine and methylparaben.

[0018] According to some embodiments of the present disclosure, the composition comprises: water, sodium colanate, carbomer, glycerin, polyethylene glycol 400, xylitol, tromethamine and methylparaben.

[0019] According to some embodiments of the present disclosure, the content of the colactate is from about 0.5 wt % to about 5.0 wt %. In some preferred embodiments, the content of the colactate is from about 0.6 wt % to about 2.5 wt %. In some more preferred embodiments, the content of the colactate is from about 0.8 wt % to about 2.0 wt %. In some more preferred embodiments, the content of the colactate is from about 1.0 wt % to about 2.0 wt %. In some more preferred embodiments, the content of the colactate is from about 1.0 wt % to about 1.5 wt %.

[0020] According to some embodiments of the present disclosure, the content of the coagulant is about 0.1 wt % to about 0.5 wt %. In some preferred embodiments, the content of the coagulant is about 0.1 wt % to about 0.3 wt % or about 0.3 wt % to about 0.5 wt %.

[0021] According to some embodiments of the present disclosure, the content of the dispersant is about 1.0 wt % to about 5.0 wt %. In some preferred embodiments, the content of the dispersant is about 1.0 wt % to about 3.0 wt % or about 3.0 wt % to about 5.0 wt %.

[0022] According to some embodiments of the present disclosure, the content of the pH adjuster is about 0.1 wt % to about 0.5 wt %, in some preferred embodiments, the content of the pH adjuster is about 0.1 wt % to about 0.4 wt %, and in some more preferred embodiments, the content of the pH adjuster is about 0.2 wt % to about 0.3 wt %.

[0023] According to some embodiments of the present disclosure, the content of the preservative is about 0.01 wt % to about 0.1 wt %. In some preferred embodiments, the content of the preservative is about 0.01 wt % to 0.02 wt %.

[0024] According to some embodiments of the present disclosure, the composition may further comprise an auxiliary agent. In some preferred embodiments, the auxiliary agent is selected from one or more of glycerol and xylitol.

[0025] According to some embodiments of the present disclosure, the content of the auxiliary agent is about 0.5 wt % to about 15 wt %, in some preferred embodiments, the content of the auxiliary agent is about 0.5 wt % to about 5 wt %, and in some more preferred embodiments, the content of the auxiliary agent is about 0.5 wt % to about 8 wt %.

[0026] According to some embodiments of the present disclosure, the composition comprises: water, sodium colanate, carbomer, polyethylene glycol 400, tromethamine and methylparaben, wherein the weight average molecular weight of the sodium colanate is 400 kDa-8000 kDa, and the content of the sodium colanate is about 0.5 wt % to about 5.0 wt %. In some preferred embodiments, the content of the sodium colanate is about 0.6 wt % to about 2.5 wt %. In some more preferred embodiments, the content of the sodium colanate is about 0.8 wt % to about 2.0 wt %. In some more preferred embodiments, the content of the sodium colanate is about 1.0 wt % to about 2.0 wt %. In some more preferred embodiments, the content of the colanate salt is about 1.0 wt % to about 1.5 wt %; the content of the carbomer is about 0.1 wt % to about 0.5 wt %. In some preferred embodiments, the content of the sodium colanate is about 0.6 wt % to about 2.5 wt %. In the embodiment, the content of the carbomer is about 0.1 wt % to about 0.3 wt % or about 0.3 wt % to about 0.5 wt %; the content of the polyethylene glycol is about 1.0 wt % to about 5.0 wt %, in some preferred embodiments, the content of the polyethylene glycol is about 1.0 wt % to about 3.0 wt % or about 3.0 wt % to about 5.0 wt %; the content of the tromethamine is about 0.1 wt % to about 0.5 wt %, in some preferred embodiments, the content of the tromethamine is about 0.1 wt % to about 0.4 wt %, in some more preferred embodiments, the content of the tromethamine is about 0.2 wt % to about 0.3 wt %; the content of the methylparaben is about 0.01 wt % to about 0.1 wt %, in some preferred embodiments, the content of the methylparaben is about 0.01 wt % to 0.02 wt %.

[0027] According to some embodiments of the present disclosure, the composition comprises: water, sodium colanate, carbomer, glycerin, polyethylene glycol 400, xylitol, tromethamine and methylparaben, wherein the weight average molecular weight of the sodium colanate is 400 kDa-8000 kDa, and the content of the sodium colanate is about 0.5 wt % to about 5.0 wt %. In some preferred embodiments, the content of the sodium colanate is about 0.6 wt % to about 2.5 wt %. In some more preferred embodiments, the content of the sodium colanate is about 0.8 wt % to about 2.0 wt %. In some more preferred embodiments, the content of the sodium colanate is about 1.0 wt % to about 2.0 wt %. In some more preferred embodiments, the content of the colanate salt is about 1.0 wt % to about 1.5 wt %; the content of the carbomer is about 0.1 wt % to about 0.5 wt %. In some preferred embodiments, the content of the sodium colanate is about 0.6 wt % to about 2.5 wt %. In a preferred embodiment, the content of the carbomer is from about 0.1 wt % to about 0.3 wt % or from about 0.3 wt % to about 0.5 wt %; the content of the polyethylene glycol is from about 1.0 wt % to about 5.0 wt %, and in some preferred embodiments, the content of the polyethylene glycol is from about 1.0 wt % to about 3.0 wt % or from about 3.0 wt % to about 5.0 wt %; the content of the tromethamine is from about 0.1 wt % to about 0.5 wt %, and in some preferred embodiments, the content of the tromethamine is from about 0.1 wt % to about 0.4 wt %, and in some more preferred embodiments, the content of the tromethamine is from about 0.2 wt % to about 0.3 wt %; the content of the methylparaben is from about 0.01 wt % to about 0.1 wt %, and in some preferred embodiments, the content of the methylparaben is from about 0.01 wt % to 0.02 wt %.

[0028] According to some embodiments of the present disclosure, the content ratio of the colactate, coagulant, and dispersant is about 0.5-5:0.1-0.5:1-5. In some preferred embodiments, the content ratio of the colactate, coagulant, and dispersant is about 0.6-2:0.1-0.5:1-5. In some more preferred embodiments, the content ratio of the colactate, coagulant, and dispersant is about 1-2:0.1-0.5:1-5.

[0029] According to some embodiments of the present disclosure, the composition comprises: water, sodium colanate, carbomer, polyethylene glycol 400, tromethamine and methylparaben, wherein the content ratio of the sodium colanate, carbomer and polyethylene glycol 400 is about 0.5-5:0.1-0.5:1-5, in some preferred embodiments, the content ratio of the sodium colanate, carbomer and polyethylene glycol 400 is about 0.6-2:0.1-0.5:1-5, and in some more preferred embodiments, the content ratio of the sodium colanate, carbomer and polyethylene glycol 400 is about 1-2:0.1-0.5:1-5.

[0030] According to some embodiments of the present disclosure, the composition comprises: water, sodium colanate, carbomer, glycerin, polyethylene glycol 400, xylitol, tromethamine and methylparaben, wherein the content ratio of the sodium colanate, carbomer and polyethylene glycol 400 is about 0.5-5:0.1-0.5:1-5, in some preferred embodiments, the content ratio of the sodium colanate, carbomer and polyethylene glycol 400 is about 0.6-2:0.1-0.5:1-5, and in some more preferred embodiments, the content ratio of the sodium colanate, carbomer and polyethylene glycol 400 is about 1-2:0.1-0.5:1-5.

[0031] Another aspect of the present disclosure provides a dressing comprising: a base material and the aforementioned composition.

[0032] According to some embodiments of the present disclosure, the substrate serves as a carrier of the dressing.

[0033] According to some embodiments of the present disclosure, the substrate is a hydrophilic fiber membrane.

[0034] According to some embodiments of the present disclosure, the substrate is one or more of non-woven fabric, gauze, fruit fiber membrane, silk membrane, Tencel membrane, bacterial cellulose membrane, trehalose membrane, chitosan membrane and binchotan membrane.

[0035] Another aspect of the present disclosure is a method for preparing the aforementioned composition or the aforementioned dressing, comprising the following steps:

[0036] (1) dissolving colanate in water and pre-treating the solution to obtain solution A;

[0037] (2) fully dissolving the coagulant in water to obtain solution B;

[0038] (3) mixing the dispersant and an optional preservative and fully dissolving them in water to obtain solution C;

[0039] (4) Pour solution C into solution B and stir to obtain solution D, and evenly disperse solution A in solution D;

[0040] (5) optionally adding a pH adjuster to adjust the pH to about 5 to about 7;

[0041] (6) Vacuum degassing;

[0042] (7) Packaging, sealing, and steam sterilization;

[0043] (8) Optionally, the resulting solution is loaded onto a carrier.

[0044] According to some embodiments of the present disclosure, the pretreatment in step (1) is steam sterilization.

[0045] According to some embodiments of the present disclosure, the temperature of the steam sterilization treatment in step (1) and / or step (7) is about 100-130°C.

[0046] According to some embodiments of the present disclosure, the time for the steam sterilization treatment in step (1) and / or step (7) is about 10-60 minutes.

[0047] According to some embodiments of the present disclosure, the colactic acid salt is sodium colactic acid. In some preferred embodiments, the number average molecular weight of sodium colactic acid is 400 kDa-8000 kDa.

[0048] According to some embodiments of the present disclosure, the coagulant is selected from one or more of carbomer, kaolin and phospholipids.

[0049] According to some preferred embodiments of the present disclosure, the coagulant is carbomer.

[0050] According to some embodiments of the present disclosure, the dispersant is one or more selected from methanol, ethanol, n-propanol, isopropanol, ethyl acetate, n-hexane and polyethylene glycol.

[0051] According to some preferred embodiments of the present disclosure, the dispersant is polyethylene glycol.

[0052] According to some embodiments of the present disclosure, the pH adjuster is one or more selected from citric acid, tartaric acid, citric acid, malic acid, chlorogenic acid, palmitic acid, glacial acetic acid, triethanolamine, sodium hydroxide, potassium hydroxide and tromethamine.

[0053] According to some preferred embodiments of the present disclosure, the pH adjuster is tromethamine.

[0054] According to some embodiments of the present disclosure, the preservative is one or more selected from sodium benzoate, potassium sorbate, sorbic acid and methylparaben.

[0055] According to some preferred embodiments of the present disclosure, the preservative is methylparaben.

[0056] According to some embodiments of the present disclosure, the composition or dressing prepared by the method comprises: water, sodium colanate, carbomer, polyethylene glycol 400, tromethamine and methylparaben.

[0057] According to some embodiments of the present disclosure, the composition or dressing prepared by the method comprises: water, sodium colanate, carbomer, glycerin, polyethylene glycol 400, xylitol, tromethamine and methylparaben.

[0058] According to some embodiments of the present disclosure, the content of the colactate is from about 0.5 wt % to about 5.0 wt %. In some preferred embodiments, the content of the colactate is from about 0.6 wt % to about 2.0 wt %. In some more preferred embodiments, the content of the colactate is from about 0.8 wt % to about 1.5 wt %. In some more preferred embodiments, the content of the colactate is from about 1.0 wt % to about 2 wt %. In some more preferred embodiments, the content of the colactate is from about 1.0 wt % to about 1.5 wt %.

[0059] According to some embodiments of the present disclosure, the content of the coagulant is about 0.1 wt % to about 0.5 wt %. In some preferred embodiments, the content of the coagulant is about 0.1 wt % to about 0.3 wt % or about 0.3 wt % to about 0.5 wt %.

[0060] According to some embodiments of the present disclosure, the content of the dispersant is about 1.0 wt % to about 5.0 wt %. In some preferred embodiments, the content of the dispersant is about 1.0 wt % to about 3.0 wt % or about 3.0 wt % to about 5.0 wt %.

[0061] According to some embodiments of the present disclosure, the content of the pH adjuster is about 0.1 wt % to about 0.5 wt %, in some preferred embodiments, the content of the pH adjuster is about 0.1 wt % to about 0.4 wt %, and in some more preferred embodiments, the content of the pH adjuster is about 0.2 wt % to about 0.3 wt %.

[0062] According to some embodiments of the present disclosure, the content of the preservative is about 0.01 wt % to about 0.1 wt %. In some preferred embodiments, the content of the preservative is about 0.01 wt % to 0.02 wt %.

[0063] According to some embodiments of the present disclosure, the composition or dressing prepared by the method comprises: water, sodium colanate, carbomer, polyethylene glycol 400, tromethamine and methylparaben, wherein the weight average molecular weight of the sodium colanate is 400 kDa-8000 kDa, and the content of the sodium colanate is about 0.5 wt % to about 5.0 wt %. In some preferred embodiments, the content of the sodium colanate is about 0.6 wt % to about 2.5 wt %. In some more preferred embodiments, the content of the sodium colanate is about 0.8 wt % to about 2.0 wt %. In some more preferred embodiments, the content of the sodium colanate is about 1.0 wt % to about 2.0 wt %. In some more preferred embodiments, the content of the colanate salt is about 1.0 wt % to about 1.5 wt %; the content of the carbomer is about 0.1 wt % to about 0.5 wt %. In some In a preferred embodiment, the content of the carbomer is about 0.1 wt % to about 0.3 wt % or about 0.3 wt % to about 0.5 wt %; the content of the polyethylene glycol is about 1.0 wt % to about 5.0 wt %, in some preferred embodiments, the content of the polyethylene glycol is about 1.0 wt % to about 3.0 wt % or about 3.0 wt % to about 5.0 wt %; the content of the tromethamine is about 0.1 wt % to about 0.5 wt %, in some preferred embodiments, the content of the tromethamine is about 0.1 wt % to about 0.4 wt %, in some more preferred embodiments, the content of the tromethamine is about 0.2 wt % to about 0.3 wt %; the content of the methylparaben is about 0.01 wt % to about 0.1 wt %, in some preferred embodiments, the content of the methylparaben is about 0.01 wt % to 0.02 wt %.

[0064] According to some embodiments of the present disclosure, the composition or dressing prepared by the method comprises: water, sodium colanate, carbomer, glycerin, polyethylene glycol 400, xylitol, tromethamine and methylparaben, wherein the weight average molecular weight of the sodium colanate is 400 kDa-8000 kDa, and the content of the sodium colanate is about 0.5 wt % to about 5.0 wt %. In some preferred embodiments, the content of the sodium colanate is about 0.6 wt % to about 2.5 wt %. In some more preferred embodiments, the content of the sodium colanate is about 0.8 wt % to about 2.0 wt %. In some more preferred embodiments, the content of the sodium colanate is about 1.0 wt % to about 2.0 wt %. In some more preferred embodiments, the content of the sodium colanate is about 1.0 wt % to about 1.5 wt %; the content of the carbomer is about 0.1 wt % to about 0.5 wt %. In some preferred embodiments, the content of the carbomer is from about 0.1 wt % to about 0.3 wt % or from about 0.3 wt % to about 0.5 wt %; the content of the polyethylene glycol is from about 1.0 wt % to about 5.0 wt %, in some preferred embodiments, the content of the polyethylene glycol is from about 1.0 wt % to about 3.0 wt % or from about 3.0 wt % to about 5.0 wt %; the content of the tromethamine is from about 0.1 wt % to about 0.5 wt %, in some preferred embodiments, the content of the tromethamine is from about 0.1 wt % to about 0.4 wt %, in some more preferred embodiments, the content of the tromethamine is from about 0.2 wt % to about 0.3 wt %; the content of the methylparaben is from about 0.01 wt % to about 0.1 wt %, in some preferred embodiments, the content of the methylparaben is from about 0.01 wt % to 0.02 wt %.

[0065] According to some embodiments of the present disclosure, the composition or dressing prepared by the method further comprises an auxiliary agent. In some preferred embodiments, the auxiliary agent is selected from one or more of glycerol and xylitol.

[0066] In a specific embodiment of the present disclosure, the content of the auxiliary agent is about 0.5 wt % to about 15 wt %, in some preferred embodiments, the content of the auxiliary agent is about 0.5 wt % to about 5 wt %, and in some more preferred embodiments, the content of the auxiliary agent is about 0.5 wt % to about 8 wt %.

[0067] According to some embodiments of the present disclosure, the content ratio of the colactate, coagulant, and dispersant is about 0.5-5:0.1-0.5:1-5. In some preferred embodiments, the content ratio of the colactate, coagulant, and dispersant is about 0.6-2:0.1-0.5:1-5. In some more preferred embodiments, the content ratio of the colactate, coagulant, and dispersant is about 1-2:0.1-0.5:1-5.

[0068] According to some embodiments of the present disclosure, the composition or dressing prepared by the method comprises: water, sodium colanate, carbomer, polyethylene glycol 400, tromethamine and methylparaben, wherein the content ratio of the sodium colanate, carbomer and polyethylene glycol 400 is about 0.5-5:0.1-0.5:1-5. In some preferred embodiments, the content ratio of the sodium colanate, carbomer and polyethylene glycol 400 is about 0.6-2:0.1-0.5:1-5. In some more preferred embodiments, the content ratio of the sodium colanate, carbomer and polyethylene glycol 400 is about 1-2:0.1-0.5:1-5.

[0069] According to some embodiments of the present disclosure, the composition or dressing prepared by the method comprises: water, sodium colanate, carbomer, glycerin, polyethylene glycol 400, xylitol, tromethamine and methylparaben, wherein the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 0.5-5:0.1-0.5:1-5. In some preferred embodiments, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 0.6-2:0.1-0.5:1-5. In some more preferred embodiments, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 1-2:0.1-0.5:1-5.

[0070] Another aspect of the present disclosure provides use of the aforementioned composition or the aforementioned dressing in preparing a post-care product for light medical aesthetics.

[0071] According to some embodiments of the present disclosure, the light medical beauty includes one or more of laser, radio frequency, ultrasound, acid peel, Thermage, ultrasonic knife, and water light injection treatment.

[0072] According to some embodiments of the present disclosure, the composition or dressing is used after a patient undergoes light medical aesthetics.

[0073] The present invention provides a dressing, preparation method, and use thereof. The colanate provided herein is a novel synthetic biomaterial used for post-operative care of light medical aesthetics, providing strong moisturizing and soothing properties, acting as a physical barrier, and promoting wound healing. The preparation process provided herein utilizes a steam pretreatment process to reduce the bacterial endotoxins and pyrogens in the colanate raw material, ensuring it meets medical-grade requirements and ensuring good biocompatibility. The preparation method provided herein improves the film-forming effect of the dressing through a scientific formulation, shortens film-forming time, and ensures its physical barrier function.

[0074] The raw materials used in this invention are scientifically formulated, and the components work synergistically. The core ingredient, colanate, provides excellent moisturizing and soothing properties, acts as a physical barrier, and promotes wound healing. Furthermore, it offers excellent breathability and biocompatibility, is easy to use, and provides a comfortable feel on the skin, making it easy to market. BRIEF DESCRIPTION OF THE DRAWINGS

[0075] The present invention can be more fully understood with reference to the following drawings.

[0076] Figure 1 The radar charts of the human efficacy evaluation of Example 1 are shown, which are the initial experience of unpacking, the experience during use, and the experience after use. DETAILED DESCRIPTION

[0077] The various features and aspects of the present invention are discussed in more detail below. It should be understood that the specific embodiments described herein are only used to illustrate the present invention and are not intended to limit the present invention.

[0078] definition

[0079] Unless otherwise defined, all technical terms and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art of the present invention. The terms used in the specification of the present invention herein are only for the purpose of describing specific embodiments and are not intended to limit the present invention.

[0080] All numerical designations used herein, such as pH values, temperatures, times, concentrations, amounts, and molecular weights, including ranges, are approximate and, where appropriate, vary by increments of 0.1 or 1.0 (+) or (-). It will be understood that, although not always explicitly stated, all numerical designations may be preceded by the term "about."

[0081] The terms "about" and "approximately" include amounts within ±10% of the associated numerical value.

[0082] As used herein, the term "solution" is a broad term that is not limited to the traditional concept and means a composition. A "solution" may be an aqueous or non-aqueous mixture, for example, it may include a homogeneous or heterogeneous mixture of a polymer and water, or it may include a suspension, a colloid, an atomized liquid, a gel, an ointment, a cream or the like.

[0083] As will be understood by those skilled in the art, for any and all purposes, particularly in terms of providing a written description, all ranges disclosed herein also encompass any and all possible subranges and combinations of subranges thereof. Any listed range can be readily identified as fully described, and the same range can be broken down into at least equal halves, thirds, quarters, fifths, tenths, etc. As a non-limiting example, each range discussed herein can be readily broken down into a lower third, a middle third, an upper third, etc.

[0084] A first aspect of the present disclosure provides a composition comprising a colanate, a coagulant, a dispersant, water, and optionally a pH adjuster and an optional preservative.

[0085] In the present invention, colanate refers to a salt formed by the reaction of colanic acid with any alkaline substance. Depending on the specific type of cation in the colanate, the colanate may be sodium colanate, potassium colanate, magnesium colanate, aluminum colanate, calcium colanate, ammonium colanate, or the like. Colanate may also contain more than one cation, such as sodium potassium colanate.

[0086] In a specific embodiment of the present disclosure, the colactic acid salt is sodium colactic acid. In some preferred embodiments, the weight average molecular weight of sodium colactic acid is 400 kDa-8000 kDa.

[0087] In a specific embodiment of the present disclosure, the coagulant is selected from one or more of carbomer, kaolin and phospholipids.

[0088] According to some preferred embodiments of the present disclosure, the coagulant is carbomer.

[0089] In a specific embodiment of the present disclosure, the dispersant is one or more selected from methanol, ethanol, n-propanol, isopropanol, ethyl acetate, n-hexane and polyethylene glycol.

[0090] According to some preferred embodiments of the present disclosure, the dispersant is polyethylene glycol.

[0091] In a specific embodiment of the present disclosure, the pH adjuster is one or more selected from citric acid, tartaric acid, citric acid, malic acid, chlorogenic acid, palmitic acid, glacial acetic acid, triethanolamine, sodium hydroxide, potassium hydroxide and tromethamine.

[0092] According to some preferred embodiments of the present disclosure, the pH adjuster is tromethamine.

[0093] In a specific embodiment of the present disclosure, the preservative is one or more selected from sodium benzoate, potassium sorbate, sorbic acid and methylparaben.

[0094] According to some preferred embodiments of the present disclosure, the preservative is methylparaben.

[0095] In a specific embodiment of the present disclosure, the composition comprises: water, sodium colanate, carbomer, polyethylene glycol 400, tromethamine and methylparaben.

[0096] In a specific embodiment of the present disclosure, the composition comprises: water, sodium colanate, carbomer, glycerin, polyethylene glycol 400, xylitol, tromethamine and methylparaben.

[0097] In specific embodiments of the present disclosure, the content of the colactone salt is from about 0.5 wt % to about 5.0 wt %. In some preferred embodiments, the content of the colactone salt is from about 0.6 wt % to about 2.5 wt %. In some more preferred embodiments, the content of the colactone salt is from about 0.8 wt % to about 2.0 wt %. In some more preferred embodiments, the content of the colactone salt is from about 1.0 wt % to about 2.0 wt %. In some more preferred embodiments, the content of the colactone salt is from about 1.0 wt % to about 1.5 wt %. For example, the colanate salt may be present in an amount of about 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1.0 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2.0 wt%, 2.1 wt%, 2.2 wt%, 2.3 wt%, 2.4 wt%, 2.5 wt%, 2.6 wt%. %, 2.7wt%, 2.8wt%, 2.9wt%, 3.0wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt%, 3.8wt%, 3.9wt%, 4.0wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt% or 5.0wt%.

[0098] In a specific embodiment of the present disclosure, the content of the coagulant is about 0.1 wt % to about 0.5 wt %. In some preferred embodiments, the content of the coagulant is about 0.1 wt % to about 0.3 wt % or about 0.3 wt % to about 0.5 wt %. For example, the content of the carbomer can be about 0.1 wt %, 0.11 wt %, 0.12 wt %, 0.13 wt %, 0.14 wt %, 0.15 wt %, 0.16 wt %, 0.17 wt %, 0.18 wt %, 0.19 wt %, 0.2 wt %, 0.21 wt %, 0.22 wt %, 0.23 wt %, 0.24 wt %, 0.25 wt %, 0.26 wt %, 0.27 wt %, 0.28 wt %, 0.29 wt%, 0.3wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37wt%, 0.38wt%, 0.39wt%, 0 .4wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt% or 0.5wt%.

[0099] In a specific embodiment of the present disclosure, the content of the dispersant is about 1.0 wt % to about 5.0 wt %. In some preferred embodiments, the content of the dispersant is about 1 wt % to about 3 wt % or about 3 wt % to about 5 wt %. For example, the content of the polyethylene glycol can be about 1.0 wt %, 1.1 wt %, 1.2 wt %, 1.3 wt %, 1.4 wt %, 1.5 wt %, 1.6 wt %, 1.7 wt %, 1.8 wt %, 1.9 wt %, 2.0 wt %, 2.1 wt %, 2.2 wt %, 2.3 wt %, 2.4 wt %, 2.5 wt %, 2.6 wt %, 2.7 wt %, 2.8 wt %, 2.9 wt %, 3.0 wt %, 3.1 wt %, 3.2 wt %, 3.3 wt %, 3.4 wt %, 3.5 wt %, 3.6 wt %, 3.7 wt %, 3.8 wt %, 3.9 wt %, 4.0 wt %, 4.1 wt %, 4.2 wt %, 4.3 wt %, 4.4 wt %, 4.5 wt %, 4.6 wt %, 4.7 wt %, 4.8 wt %, 4.9 wt %, 5. 9wt%, 3.0wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt%, 3.8wt%, 3.9wt%, 4.0wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt% or 5.0wt%.

[0100] In a specific embodiment of the present disclosure, the content of the pH adjuster is about 0.1 wt % to about 0.5 wt %. In some preferred embodiments, the content of the pH adjuster is about 0.1 wt % to about 0.4 wt %. In some more preferred embodiments, the content of the pH adjuster is about 0.2 wt % to about 0.3 wt %. For example, the content of tromethamine can be about 0.1 wt %, 0.11 wt %, 0.12 wt %, 0.13 wt %, 0.14 wt %, 0.15 wt %, 0.16 wt %, 0.17 wt %, 0.18 wt %, 0.19 wt %, 0.2 wt %, 0.21 wt %, 0.22 wt %, 0.23 wt %, 0.24 wt %, 0.25 wt %, 0.26 wt %, 0.27 wt %, 0.28 wt %, 0.29 wt %, 0.30 wt %, 0.31 wt %, 0.32 wt %, 0.33 wt %, 0.34 wt %, 0.35 wt %, 0.36 wt %, 0.37 wt %, 0.38 wt %, 0.39 wt %, 0.40 wt %, 0.41 wt %, 0.42 wt %, 0.43 wt %, 0.44 wt %, 0.45 wt %, 0.46 wt %, 0.47 wt %, 0.48 wt %, 0.49 wt %, 0.50 wt %, 0.51 wt %, 0.52 wt %, 0.53 wt %, 0. 9wt%, 0.3wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37wt%, 0.38wt%, 0.39wt%, 0.4wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt% or 0.5wt%.

[0101] In a specific embodiment of the present disclosure, the content of the preservative is about 0.01wt% to about 0.1wt%. In some preferred embodiments, the content of the preservative is about 0.01wt% to 0.02wt%. For example, the content of the preservative is about 0.01wt%, 0.02wt%, 0.03wt%, 0.04wt%, 0.05wt%, 0.06wt%, 0.07wt%, 0.08wt%, 0.09wt% or 0.1wt%.

[0102] In a specific embodiment of the present disclosure, the composition further comprises an auxiliary agent. In some preferred embodiments, the auxiliary agent is selected from one or more of glycerol and xylitol.

[0103] In a specific embodiment of the present disclosure, the content of the auxiliary agent is about 0.5 wt % to about 15 wt %, in some preferred embodiments, the content of the auxiliary agent is about 0.5 wt % to about 5 wt %, and in some more preferred embodiments, the content of the auxiliary agent is about 0.5 wt % to about 8 wt %. For example, the content of the auxiliary agent is about 0.5 wt %, 0.6 wt %, 0.6 wt %, 0.7 wt %, 0.8 wt %, 0.9 wt %, 1 wt %, 2 wt %, 3 wt %, 4 wt %, 5 wt %, 6 wt %, 7 wt %, 8 wt %, 9 wt %, 10 wt %, 11 wt %, 12 wt %, 13 wt %, 14 wt % or 15 wt %.

[0104] In a specific embodiment of the present disclosure, the content ratio of the colactate, coagulant, and dispersant is about 0.5-5:0.1-0.5:1-5. In some preferred embodiments, the content ratio of the colactate, coagulant, and dispersant is about 0.6-2:0.1-0.5:1-5. In some more preferred embodiments, the content ratio of the colactate, coagulant, and dispersant is about 1-2:0.1-0.5:1-5. For example, the content ratio of the colanate, coagulant and dispersant may be about 0.5:0.1:0.6, 0.5:0.1:0.7, 0.5:0.1:0.8, 0.5:0.1:0.9, 0.5:0.1:1, 0.5:0.1:2, 0.5:0.1:3, 0.5:0.1:4, 0.5:0.1:5, 0.5:0.2:0.6, 0.5:0.2:0.7, 0.5:0.2:0.8, 0.5:0.2:0.9, 0.5:0.2:1, 0.5:0.2:2, 0.5:0.1:3, 0.5:0.1:4, 0.5:0.1:5, 0.5:0.2:0.6, 0.5:0.2:0.7, 0.5:0.2:0.8, 0.5:0.2:0.9, 0.5:0.2:1, 0.5:0.2:2, 0.5:0.2:3, 0.5:0.1:4, 0.5:0.1:5 .5:0.2:5、0.5:0.3:0.6、0.5:0.3:0.7、0.5:0.3:0.8、0.5:0.3:0.9、0.5:0.3:1、0.5:0.3:2、0.5:0.3:3、0.5:0.3:4、0.5:0.3:5、0.5:0.4:0.6、0.5:0.4:0.7、0.5:0.4:0.8、0.5:0.4:0.9、0.5:0.4:1、0.5:0.4:2、0.5:0.4:3、0.5:0.4:4、0.5:0.4:5、0.5:0.5: 0.6、0.5:0.5:0.7、0.5:0.5:0.8、0.5:0.5:0.9、0.5:0.5:1、0.5:0.5:2、0.5:0.5:3、0.5:0.5:4、0.5:0.5:5、0.6:0.1:0.6、0.6:0.1:0.7、0.6:0.1:0.8、0.6:0.1:0.9、0.6:0.1:1、0.6:0.1:2、0.6:0.1:3、0.6:0.1:4、0.6:0.1:5、0.6:0.2:0.6、0.6:0.2:0.7、0 .6:0.2:0.8, 0.6:0.2:0.9, 0.6:0.2:1, 0.6:0.2:2, 0.6:0.2:3, 0.6:0.2:4, 0.6:0.2:5, 0.6:0.3:0.6, 0.6:0.3:0.7, 0.6:0.3:0.8, 0.6:0.3:0.9, 0.6:0.3:1, 0.6:0.3:2, 0.6:0.3:3, 0.6:0.3:4, 0.6:0.3:5, 0.6:0.4:0.6, 0.6:0.4:0.7, 0.6:0.4:0.8, 0.6:0.4:0.9、0.6:0.4:1、0.6:0.4:2、0.6:0.4:3、0.6:0.4:4、0.6:0.4:5、0.6:0.5:0.6、0.6:0.5:0.7、0.6:0.5:0.8、0.6:0.5:0.9、0.6:0.5:1、0.6:0.5:2、0.6:0.5:3、0.6:0.5:4、0.6:0.5:5、0.7:0.1:0.6、0.7:0.1:0.7、0.7:0.1:0.8、0.7:0.1:0.9、0.7:0.1:1、0.7:0.1:2、0.7:0.1:3、0.7:0.1:4、0.7:0.1:5、0.7:0.2:0.6、0.7:0.2:0.7、0.7:0.2:0.8、0.7:0.2:0.9、0.7:0.2:1、0.7:0.2:2、0.7:0.2:3、0.7:0.2:4、0.7:0.2:5、0.7:0.3:0.6、0.7:0.3:0.7、0.7:0.3:0.8、0.7:0.3:0.9、0.7:0.3:1、0.7:0.3:2、0.7:0.3:3、0.7:0.3:4、0.7:0.3:5、0.7:0.4:0.6、0.7:0.4:0.7、0.7:0.4:0.8、0.7:0.4:0.9、0.7:0.4:1、0.7:0.4:2、0.7:0.4:3、0.7:0.4:4、0.7:0.4:5、0.7:0.5:0.6、0.7:0.5:0.7、0.7:0.5:0.8、0.7:0.5:0.9、0.7:0.5:1、0.7:0.5:2、0.7:0.5:3、0.7:0.5:4、0.7:0.5:5、0.8:0.1:0.6、0.8:0.1:0.7、0.8:0.1:0.8、0.8:0.1:0.9、0.8:0.1:1、0.8:0.1:2、0.8:0.1:3、0.8:0.1:4、0.8:0.1:5、0.8:0.2:0.6、0.8:0.2:0.7、0.8:0.2:0.8、0.8:0.2:0.9、0.8:0.2:1、0.8:0.2:2、0.8:0.2:3、0.8:0.2:4、0.8:0.2:5、0.8:0.3:0.6、0.8:0.3:0.7、0.8:0.3:0.8、0.8:0.3:0.9、0.8:0.3:1、0.8:0.3:2、0.8:0.3:3、0.8:0.3:4、0.8:0.3:5、0.8:0.4:0.6、0.8:0.4:0.7、0.8:0.4:0.8、0.8:0.4:0.9、0.8:0.4:1、0.8:0.4:2、0.8:0.4:3、0.8:0.4:4、0.8:0.4:5、0.8:0.5:0.6、0.8:0.5:0.7、0.8:0.5:0.8、0.8:0.5:0.9、0.8:0.5:1、0.8:0.5:2、0.8:0.5:3、0.8:0.5:4、0.8:0.5:5、0.9:0.1:0.6、0.9:0.1:0.7、0.9:0.1:0.8、0.9:0.1:0.9、0.9:0.1:1、0.9:0.1:2、0.9:0.1:3、0.9:0.1:4、0.9:0.1:5、0.9:0.2:0.6、0.9:0.2:0.7、0.9:0.2:0.8、0.9:0.2:0.9、0.9:0.2:1、0.9:0.2:2、0.9:0.2:3、0.9:0.2:4、0.9:0.2:5、0.9:0.3:0.6、0.9:0.3:0.7、0.9:0.3:0.8、0.9:0.3:0.9、0.9:0.3:1、0.9:0.3:2、0.9:0.3:3、0.9:0.3:4、0.9:0.3:5、0.9:0.4:0.6、0.9:0.4:0.7、0.9:0.4:0.8、0.9:0.4:0.9、0.9:0.4:1、0.9:0.4:2、0.9:0.4:3、0.9:0.4:4、0.9:0.4:5、0.9:0.5:0.6、0.9:0.5:0.7、0.9:0.5:0.8、0.9:0.5:0.9、0.9:0.5:1、0.9:0.5:2、0.9:0.5:3、0.9:0.5:4、0.9:0.5:5、1:0.1:0.6、1:0.1:0.7、1:0.1:0.8、1:0.1:0.9、1:0.1:1、1:0.1:2、1:0.1:3、1:0.1:4、1:0.1:5、1:0.2:0.6、1:0.2:0.7、1:0.2:0.8、1:0.2:0.9、1:0.2:1、1:0.2:2、1:0.2:3、1:0.2:4、1:0.2:5、1:0.3:0.6、1:0.3:0.7、1:0.3:0.8、1:0.3:0.9、1:0.3:1、1:0.3:2、1:0.3:3、1:0.3:4、1:0.3:5、1:0.4:0.6、1:0.4:0.7、1:0.4:0.8、1:0.4:0.9、1:0.4:1、1:0.4:2、1:0.4:3、1:0.4:4、1:0.4:5、1:0.5:0.6、1:0.5:0.7、1:0.5:0.8、1:0.5:0.9、1:0.5:1、1:0.5:2、1:0.5:3、1:0.5:4、1:0.5:5、2:0.1:0.6、2:0.1:0.7、2:0.1:0.8、2:0.1:0.9、2:0.1:1、2:0.1:2、2:0.1:3、2:0.1:4、2:0.1:5、2:0.2:0.6、2:0.2:0.7、2:0.2:0.8、2:0.2:0.9、2:0.2:1、2:0.2:2、2:0.2:3、2:0.2:4、2:0.2:5、2:0.3:0.6、2:0.3:0.7、2:0.3:0.8、2:0.3:0.9、2:0.3:1、2:0.3:2、2:0.3:3、2:0.3:4、2:0.3:5、2:0.4:0.6、2:0.4:0.7、2:0.4:0.8、2:0.4:0.9、2:0.4:1、2:0.4:2、2:0.4:3、2:0.4:4、2:0.4:5、2:0.5:0.6、2:0.5:0.7、2:0.5:0.8、2:0.5:0.9、2:0.5:1、2:0.5:2、2:0.5:3、2:0.5:4、2:0.5:5、3:0.1:0.6、3:0.1:0.7、3:0.1:0.8、3:0.1:0.9、3:0.1:1、3:0.1:2、3:0.1:3、3:0.1:4、3:0.1:5、3:0.2:0.6、3:0.2:0.7、3:0.2:0.8、3:0.2:0.9、3:0.2:1、3:0.2:2、3:0.2:3、3:0.2:4、3:0.2:5、3:0.3:0.6、3:0.3:0.7、3:0.3:0.8、3:0.3:0.9、3:0.3:1、3:0.3:2、3:0.3:3、3:0.3:4、3:0.3:5、3:0.4:0.6、3:0.4:0.7、3:0.4:0.8、3:0.4:0.9、3:0.4:1、3:0.4:2、3:0.4:3、3:0.4:4、3:0.4:5、3:0.5:0.6、3:0.5:0.7、3:0.5:0.8、3:0.5:0.9、3:0.5:1、3:0.5:2、3:0.5:3、3:0.5:4、3:0.5:5、4:0.1:0.6、4:0.1:0.7、4:0.1:0.8、4:0.1:0.9、4:0.1:1、4:0.1:2、4:0.1:3、4:0.1:4、4:0.1:5、4:0.2:0.6、4:0.2:0.7、4:0.2:0.8、4:0.2:0.9、4:0.2:1、4:0.2:2、4:0.2:3、4:0.2:4、4:0.2:5、4:0.3:0.6, 4:0.3:0.7, 4:0.3:0.8, 4:0.3:0.9, 4:0.3:1, 4:0.3:2, 4:0.3:3, 4:0.3:4, 4:0.3:5, 4:0.4:0.6, 4:0.4:0.7, 4:0.4:0.8, 4:0.4:0.9, 4:0.4:1, 4:0.4:2, 4:0.4:3, 4:0.4:4, 4:0.4:5, 4:0.5: 0.6, 4:0.5:0.7, 4:0.5:0.8, 4:0.5:0.9, 4:0.5:1, 4:0.5:2, 4:0.5:3, 4:0.5:4, 4:0.5:5, 5:0.1:0.6, 5:0.1:0.7, 5:0.1:0.8, 5:0.1:0.9, 5:0.1:1, 5:0.1:2, 5:0.1:3, 5:0.1:4, 5:0.1:5, 5:0. 2:0.6、5:0.2:0.7、5:0.2:0.8、5:0.2:0.9、5:0.2:1、5:0.2:2、5:0.2:3、5:0.2:4、5:0.2:5、5:0.3:0.6、5:0.3:0.7、5:0.3:0.8、5:0.3:0.9、5:0.3:1、5:0.3:2、5:0.3:3、5:0.3:4、5:0.3:5、5: 0.4:0.6, 5:0.4:0.7, 5:0.4:0.8, 5:0.4:0.9, 5:0.4:1, 5:0.4:2, 5:0.4:3, 5:0.4:4, 5:0.4:5, 5:0.5:0.6, 5:0.5:0.7, 5:0.5:0.8, 5:0.5:0.9, 5:0.5:1, 5:0.5:2, 5:0.5:3, 5:0.5:4 or 5:0.5:5.

[0105] In a specific embodiment of the present disclosure, the composition comprises: water, sodium colanate, carbomer, polyethylene glycol 400, tromethamine and methylparaben. The weight average molecular weight of the sodium colanate is 400 kDa-8000 kDa, and the content of the sodium colanate is about 0.5 wt % to about 5.0 wt %. In some preferred embodiments, the content of the sodium colanate is about 0.6 wt % to about 2.5 wt %. In some more preferred embodiments, the content of the sodium colanate is about 0.8 wt % to about 2.0 wt %. In some more preferred embodiments, the content of the sodium colanate is about 1.0 wt % to about 2.0 wt %. In some more preferred embodiments, the content of the sodium colanate is about 1.0 wt % to about 1.5 wt %. For example, the content of the sodium colanate can be about 0.5 wt %, 0.6 wt %, 0.7 wt %, 0.8 wt %, 0.9 wt %, 1.0 wt %, 1.1 wt %. %, 1.2wt%, 1.3wt%, 1.4wt%, 1.5wt%, 1.6wt%, 1.7wt%, 1.8wt%, 1.9wt%, 2.0wt%, 2.1wt%, 2.2wt%, 2.3wt%, 2.4wt%, 2.5wt%, 2.6wt%, 2.7wt%, 2.8wt%, 2.9wt%, 3.0wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt%, 3.8wt%, 3.9wt%, 4.0wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt% or 5.0wt%.The content of the carbomer is about 0.1wt% to about 0.5wt%. In some preferred embodiments, the content of the carbomer is about 0.1wt% to about 0.3wt% or about 0.3wt% to about 0.5wt%. For example, the content of the carbomer can be about 0.1wt%, 0.11wt%, 0.12wt%, 0.13wt%, 0.14wt%, 0.15wt%, 0.16wt%, 0.17wt%, 0.18wt%, 0.19wt%, 0.2wt%, 0.21wt%, 0.22wt%, 0.23wt%, 0.24wt%. wt%, 0.25wt%, 0.26wt%, 0.27wt%, 0.28wt%, 0.29wt%, 0.3wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37w t%, 0.38wt%, 0.39wt%, 0.4wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt% or 0.5wt%. The content of the polyethylene glycol is about 1 wt % to about 5 wt %. In some preferred embodiments, the content of the polyethylene glycol is about 1 wt % to about 3 wt % or about 3 wt % to about 5 wt %. For example, the content of the polyethylene glycol can be about 1.0 wt %, 1.1 wt %, 1.2 wt %, 1.3 wt %, 1.4 wt %, 1.5 wt %, 1.6 wt %, 1.7 wt %, 1.8 wt %, 1.9 wt %, 2.0 wt %, 2.1 wt %, 2.2 wt %, 2.3 wt %, 2.4 wt%, 2.5wt%, 2.6wt%, 2.7wt%, 2.8wt%, 2.9wt%, 3.0wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt %, 3.8wt%, 3.9wt%, 4.0wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt% or 5.0wt%.The content of the tromethamine is about 0.1wt% to about 0.5wt%, in some preferred embodiments, the content of the tromethamine is about 0.1wt% to about 0.4wt%, in some more preferred embodiments, the content of the tromethamine is about 0.2wt% to about 0.3wt%; for example, the content of the tromethamine can be about 0.1wt%, 0.11wt%, 0.12wt%, 0.13wt%, 0.14wt%, 0.15wt%, 0.16wt%, 0.17wt%, 0.18wt%, 0.19wt%, 0.2wt%, 0.21wt%, 0.22wt%, % , 0.23wt%, 0.24wt%, 0.25wt%, 0.26wt%, 0.27wt%, 0.28wt%, 0.29wt%, 0.3wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37wt%, 0.38wt%, 0.39wt%, 0.4wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt% or 0.5wt%. The content of the methylparaben is about 0.01 wt % to about 0.1 wt %. In some preferred embodiments, the content of the methylparaben is about 0.01 wt % to 0.02 wt %; for example, the content of the methylparaben is about 0.01 wt %, 0.02 wt %, 0.03 wt %, 0.04 wt %, 0.05 wt %, 0.06 wt %, 0.07 wt %, 0.08 wt %, 0.09 wt % or 0.1 wt %.

[0106] In a specific embodiment of the present disclosure, the composition comprises: water, sodium colanate, carbomer, glycerin, polyethylene glycol 400, xylitol, tromethamine and methylparaben. The weight average molecular weight of the sodium colanate is 400 kDa-8000 kDa, and the content of the sodium colanate is about 0.5 wt % to about 5.0 wt %. In some preferred embodiments, the content of the sodium colanate is about 0.6 wt % to about 2.5 wt %. In some more preferred embodiments, the content of the sodium colanate is about 0.8 wt % to about 2.0 wt %. In some more preferred embodiments, the content of the sodium colanate is about 1.0 wt % to about 2.0 wt %. In some more preferred embodiments, the content of the sodium colanate is about 1.0 wt % to about 1.5 wt %. For example, the content of the sodium colanate can be about 0.5 wt %, 0.6 wt %, 0.7 wt %, 0.8 wt %, 0.9 wt %, 1.0 wt %, 1.1 wt %. %, 1.2wt%, 1.3wt%, 1.4wt%, 1.5wt%, 1.6wt%, 1.7wt%, 1.8wt%, 1.9wt%, 2.0wt%, 2.1wt%, 2.2wt%, 2.3wt%, 2.4wt%, 2.5wt%, 2.6wt%, 2.7wt%, 2.8wt%, 2.9wt%, 3.0wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt%, 3.8wt%, 3.9wt%, 4.0wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt% or 5.0wt%.The content of the carbomer is about 0.1wt% to about 0.5wt%. In some preferred embodiments, the content of the carbomer is about 0.1wt% to about 0.3wt% or about 0.3wt% to about 0.5wt%. For example, the content of the carbomer can be about 0.1wt%, 0.11wt%, 0.12wt%, 0.13wt%, 0.14wt%, 0.15wt%, 0.16wt%, 0.17wt%, 0.18wt%, 0.19wt%, 0.2wt%, 0.21wt%, 0.22wt%, 0.23wt%, 0.24wt%. wt%, 0.25wt%, 0.26wt%, 0.27wt%, 0.28wt%, 0.29wt%, 0.3wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37w t%, 0.38wt%, 0.39wt%, 0.4wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt% or 0.5wt%. The content of the polyethylene glycol is about 1 wt % to about 5 wt %. In some preferred embodiments, the content of the polyethylene glycol is about 1 wt % to about 3 wt % or about 3 wt % to about 5 wt %. For example, the content of the polyethylene glycol can be about 1.0 wt %, 1.1 wt %, 1.2 wt %, 1.3 wt %, 1.4 wt %, 1.5 wt %, 1.6 wt %, 1.7 wt %, 1.8 wt %, 1.9 wt %, 2.0 wt %, 2.1 wt %, 2.2 wt %, 2.3 wt %, 2.4 wt%, 2.5wt%, 2.6wt%, 2.7wt%, 2.8wt%, 2.9wt%, 3.0wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt %, 3.8wt%, 3.9wt%, 4.0wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt% or 5.0wt%.The content of the tromethamine is about 0.1wt% to about 0.5wt%, in some preferred embodiments, the content of the tromethamine is about 0.1wt% to about 0.4wt%, in some more preferred embodiments, the content of the tromethamine is about 0.2wt% to about 0.3wt%; for example, the content of the tromethamine can be about 0.1wt%, 0.11wt%, 0.12wt%, 0.13wt%, 0.14wt%, 0.15wt%, 0.16wt%, 0.17wt%, 0.18wt%, 0.19wt%, 0.2wt%, 0.21wt%, 0.22wt%, % , 0.23wt%, 0.24wt%, 0.25wt%, 0.26wt%, 0.27wt%, 0.28wt%, 0.29wt%, 0.3wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37wt%, 0.38wt%, 0.39wt%, 0.4wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt% or 0.5wt%. The content of the methylparaben is about 0.01 wt % to about 0.1 wt %. In some preferred embodiments, the content of the methylparaben is about 0.01 wt % to 0.02 wt %; for example, the content of the methylparaben is about 0.01 wt %, 0.02 wt %, 0.03 wt %, 0.04 wt %, 0.05 wt %, 0.06 wt %, 0.07 wt %, 0.08 wt %, 0.09 wt % or 0.1 wt %.

[0107] In a specific embodiment of the present disclosure, the composition comprises: water, sodium colanate, carbomer, polyethylene glycol 400, tromethamine and methylparaben, wherein the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 0.5-5:0.1-0.5:1-5. In some preferred embodiments, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 0.6-2:0.1-0.5:1-5. In some more preferred embodiments, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 1-2:0.1-0.5:1-5. For example, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 can be about 0.5:0.1:0.6, 0.5:0.1:0.7, 0.5:0.1:0.8, 0.5:0.1:0.9, 0.5:0.1:1, 0.5:0.1:2, 0.5:0.1:3, 0.5:0.1:4, 0.5:0.1:5, 0.5:0.2:0.6, 0.5:0.2:0.7, 0.5:0.2:0.8, 0.5:0.2:0.9, 0.5:0.2:1, 0.5:0.2:2, 0.5:0.1:3, 0.5:0.1:4, 0.5:0.1:5, 0.5:0.2:0.6, 0.5:0.2:0.7, 0.5:0.2:0.8, 0.5:0.2:0.9, 0.5:0.2:1, 0.5:0.2:2, 0.5:0.1:3. 0.2:3、0.5:0.2:4、0.5:0.2:5、0.5:0.3:0.6、0.5:0.3:0.7、0.5:0.3:0.8、0.5:0.3:0.9、0.5:0.3:1、0.5:0.3:2、0.5:0.3:3、0.5:0.3:4、0.5:0.3:5、0.5:0.4:0.6、0.5:0.4:0.7、0.5:0.4:0.8、0.5:0.4:0.9、0.5:0.4:1、0.5:0.4:2、0.5:0.4: 3, 0.5:0.4:4, 0.5:0.4:5, 0.5:0.5:0.6, 0.5:0.5:0.7, 0.5:0.5:0.8, 0.5:0.5:0.9, 0.5:0.5:1, 0.5:0.5:2, 0.5:0.5:3, 0.5:0.5:4, 0.5:0.5:5, 0.6:0.1:0.6, 0.6:0.1:0.7, 0.6:0.1:0.8, 0.6:0.1:0.9, 0.6:0.1:1, 0.6:0.1:2, 0.6:0.1:3, 0. 6:0.1:4, 0.6:0.1:5, 0.6:0.2:0.6, 0.6:0.2:0.7, 0.6:0.2:0.8, 0.6:0.2:0.9, 0.6:0.2:1, 0.6:0.2:2, 0.6:0.2:3, 0.6:0.2:4, 0.6:0.2:5, 0.6:0.3:0.6, 0.6:0.3:0.7, 0.6:0.3:0.8, 0.6:0.3:0.9, 0.6:0.3:1, 0.6:0.3:2, 0.6:0.3:3, 0.6:0.3:4、0.6:0.3:5、0.6:0.4:0.6、0.6:0.4:0.7、0.6:0.4:0.8、0.6:0.4:0.9、0.6:0.4:1、0.6:0.4:2、0.6:0.4:3、0.6:0.4:4、0.6:0.4:5、0.6:0.5:0.6、0.6:0.5:0.7、0.6:0.5:0.8、0.6:0.5:0.9、0.6:0.5:1、0.6:0.5:2、0.6:0.5:3、0.6:0.5:4、0.6:0.5:5、0.7:0.1:0.6、0.7:0.1:0.7、0.7:0.1:0.8、0.7:0.1:0.9、0.7:0.1:1、0.7:0.1:2、0.7:0.1:3、0.7:0.1:4、0.7:0.1:5、0.7:0.2:0.6、0.7:0.2:0.7、0.7:0.2:0.8、0.7:0.2:0.9、0.7:0.2:1、0.7:0.2:2、0.7:0.2:3、0.7:0.2:4、0.7:0.2:5、0.7:0.3:0.6、0.7:0.3:0.7、0.7:0.3:0.8、0.7:0.3:0.9、0.7:0.3:1、0.7:0.3:2、0.7:0.3:3、0.7:0.3:4、0.7:0.3:5、0.7:0.4:0.6、0.7:0.4:0.7、0.7:0.4:0.8、0.7:0.4:0.9、0.7:0.4:1、0.7:0.4:2、0.7:0.4:3、0.7:0.4:4、0.7:0.4:5、0.7:0.5:0.6、0.7:0.5:0.7、0.7:0.5:0.8、0.7:0.5:0.9、0.7:0.5:1、0.7:0.5:2、0.7:0.5:3、0.7:0.5:4、0.7:0.5:5、0.8:0.1:0.6、0.8:0.1:0.7、0.8:0.1:0.8、0.8:0.1:0.9、0.8:0.1:1、0.8:0.1:2、0.8:0.1:3、0.8:0.1:4、0.8:0.1:5、0.8:0.2:0.6、0.8:0.2:0.7、0.8:0.2:0.8、0.8:0.2:0.9、0.8:0.2:1、0.8:0.2:2、0.8:0.2:3、0.8:0.2:4、0.8:0.2:5、0.8:0.3:0.6、0.8:0.3:0.7、0.8:0.3:0.8、0.8:0.3:0.9、0.8:0.3:1、0.8:0.3:2、0.8:0.3:3、0.8:0.3:4、0.8:0.3:5、0.8:0.4:0.6、0.8:0.4:0.7、0.8:0.4:0.8、0.8:0.4:0.9、0.8:0.4:1、0.8:0.4:2、0.8:0.4:3、0.8:0.4:4、0.8:0.4:5、0.8:0.5:0.6、0.8:0.5:0.7、0.8:0.5:0.8、0.8:0.5:0.9、0.8:0.5:1、0.8:0.5:2、0.8:0.5:3、0.8:0.5:4、0.8:0.5:5、0.9:0.1:0.6、0.9:0.1:0.7、0.9:0.1:0.8、0.9:0.1:0.9、0.9:0.1:1、0.9:0.1:2、0.9:0.1:3、0.9:0.1:4、0.9:0.1:5、0.9:0.2:0.6、0.9:0.2:0.7、0.9:0.2:0.8、0.9:0.2:0.9、0.9:0.2:1、0.9:0.2:2、0.9:0.2:3、0.9:0.2:4、0.9:0.2:5、0.9:0.3:0.6、0.9:0.3:0.7、0.9:0.3:0.8、0.9:0.3:0.9、0.9:0.3:1、0.9:0.3:2、0.9:0.3:3、0.9:0.3:4、0.9:0.3:5、0.9:0.4:0.6、0.9:0.4:0.7、0.9:0.4:0.8、0.9:0.4:0.9、0.9:0.4:1、0.9:0.4:2、0.9:0.4:3、0.9:0.4:4、0.9:0.4:5、0.9:0.5:0.6、0.9:0.5:0.7、0.9:0.5:0.8、0.9:0.5:0.9、0.9:0.5:1、0.9:0.5:2、0.9:0.5:3、0.9:0.5:4、0.9:0.5:5、1:0.1:0.6、1:0.1:0.7、1:0.1:0.8、1:0.1:0.9、1:0.1:1、1:0.1:2、1:0.1:3、1:0.1:4、1:0.1:5、1:0.2:0.6、1:0.2:0.7、1:0.2:0.8、1:0.2:0.9、1:0.2:1、1:0.2:2、1:0.2:3、1:0.2:4、1:0.2:5、1:0.3:0.6、1:0.3:0.7、1:0.3:0.8、1:0.3:0.9、1:0.3:1、1:0.3:2、1:0.3:3、1:0.3:4、1:0.3:5、1:0.4:0.6、1:0.4:0.7、1:0.4:0.8、1:0.4:0.9、1:0.4:1、1:0.4:2、1:0.4:3、1:0.4:4、1:0.4:5、1:0.5:0.6、1:0.5:0.7、1:0.5:0.8、1:0.5:0.9、1:0.5:1、1:0.5:2、1:0.5:3、1:0.5:4、1:0.5:5、2:0.1:0.6、2:0.1:0.7、2:0.1:0.8、2:0.1:0.9、2:0.1:1、2:0.1:2、2:0.1:3、2:0.1:4、2:0.1:5、2:0.2:0.6、2:0.2:0.7、2:0.2:0.8、2:0.2:0.9、2:0.2:1、2:0.2:2、2:0.2:3、2:0.2:4、2:0.2:5、2:0.3:0.6、2:0.3:0.7、2:0.3:0.8、2:0.3:0.9、2:0.3:1、2:0.3:2、2:0.3:3、2:0.3:4、2:0.3:5、2:0.4:0.6、2:0.4:0.7、2:0.4:0.8、2:0.4:0.9、2:0.4:1、2:0.4:2、2:0.4:3、2:0.4:4、2:0.4:5、2:0.5:0.6、2:0.5:0.7、2:0.5:0.8、2:0.5:0.9、2:0.5:1、2:0.5:2、2:0.5:3、2:0.5:4、2:0.5:5、3:0.1:0.6、3:0.1:0.7、3:0.1:0.8、3:0.1:0.9、3:0.1:1、3:0.1:2、3:0.1:3、3:0.1:4、3:0.1:5、3:0.2:0.6、3:0.2:0.7、3:0.2:0.8、3:0.2:0.9、3:0.2:1、3:0.2:2、3:0.2:3、3:0.2:4、3:0.2:5、3:0.3:0.6、3:0.3:0.7、3:0.3:0.8、3:0.3:0.9、3:0.3:1、3:0.3:2、3:0.3:3、3:0.3:4、3:0.3:5、3:0.4:0.6、3:0.4:0.7、3:0.4:0.8、3:0.4:0.9、3:0.4:1、3:0.4:2、3:0.4:3、3:0.4:4、3:0.4:5、3:0.5:0.6、3:0.5:0.7、3:0.5:0.8、3:0.5:0.9、3:0.5:1、3:0.5:2、3:0.5:3、3:0.5:4、3:0.5:5、4:0.1:0.6、4:0.1:0.7、4:0.1:0.8、4:0.1:0.9、4:0.1:1、4:0.1:2、4:0.1:3、4:0.1:4、4:0.1:5、4:0.2:0.6、4:0.2:0.7、4:0.2:0.8、4:0.2:0.9, 4:0.2:1, 4:0.2:2, 4:0.2:3, 4:0.2:4, 4:0.2:5, 4:0.3:0.6, 4:0.3:0.7, 4:0.3:0.8, 4:0.3:0.9, 4:0.3:1, 4:0.3:2, 4:0.3:3, 4:0.3:4, 4:0.3:5, 4:0.4:0.6, 4:0.4:0.7, 4:0.4:0.8, 4:0.4:0.9, 4:0.4 :1, 4:0.4:2, 4:0.4:3, 4:0.4:4, 4:0.4:5, 4:0.5:0.6, 4:0.5:0.7, 4:0.5:0.8, 4:0.5:0.9, 4:0.5:1, 4:0.5:2, 4:0.5:3, 4:0.5:4, 4:0.5:5, 5:0.1:0.6, 5:0.1:0.7, 5:0.1:0.8, 5:0.1:0.9, 5:0.1:1, 5:0.1:2, 5 :0.1:3, 5:0.1:4, 5:0.1:5, 5:0.2:0.6, 5:0.2:0.7, 5:0.2:0.8, 5:0.2:0.9, 5:0.2:1, 5:0.2:2, 5:0.2:3, 5:0.2:4, 5:0.2:5, 5:0.3:0.6, 5:0.3:0.7, 5:0.3:0.8, 5:0.3:0.9, 5:0.3:1, 5:0.3:2, 5:0.3:3, 5:0. 3:4, 5:0.3:5, 5:0.4:0.6, 5:0.4:0.7, 5:0.4:0.8, 5:0.4:0.9, 5:0.4:1, 5:0.4:2, 5:0.4:3, 5:0.4:4, 5:0.4:5, 5:0.5:0.6, 5:0.5:0.7, 5:0.5:0.8, 5:0.5:0.9, 5:0.5:1, 5:0.5:2, 5:0.5:3, 5:0.5:4 or 5:0.5:5.

[0108] In a specific embodiment of the present disclosure, the composition comprises: water, sodium colanate, carbomer, glycerin, polyethylene glycol 400, xylitol, tromethamine and methylparaben, wherein the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 0.5-5:0.1-0.5:1-5, in some preferred embodiments, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 0.6-2:0.1-0.5:1-5, and in some more preferred embodiments, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 1-2:0.1-0.5:1-5. For example, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 can be about 0.5:0.1:0.6, 0.5:0.1:0.7, 0.5:0.1:0.8, 0.5:0.1:0.9, 0.5:0.1:1, 0.5:0.1:2, 0.5:0.1:3, 0.5:0.1:4, 0.5:0.1:5, 0.5:0.2:0.6, 0.5:0.2:0.7, 0.5:0.2:0.8, 0.5:0.2:0.9, 0.5:0.2:1, 0.5:0.2:2, 0.5:0.1:3, 0.5:0.1:4, 0.5:0.1:5, 0.5:0.2:0.6, 0.5:0.2:0.7, 0.5:0.2:0.8, 0.5:0.2:0.9, 0.5:0.2:1, 0.5:0.2:2, 0.5:0.1:3. 5:0.2:3、0.5:0.2:4、0.5:0.2:5、0.5:0.3:0.6、0.5:0.3:0.7、0.5:0.3:0.8、0.5:0.3:0.9、0.5:0.3:1、0.5:0.3:2、0.5:0.3:3、0.5:0.3:4、0.5:0.3:5、0.5:0.4:0.6、0.5:0.4:0.7、0.5:0.4:0.8、0.5:0.4:0.9、0.5:0.4:1、0.5:0.4:2、0.5 :0.4:3、0.5:0.4:4、0.5:0.4:5、0.5:0.5:0.6、0.5:0.5:0.7、0.5:0.5:0.8、0.5:0.5:0.9、0.5:0.5:1、0.5:0.5:2、0.5:0.5:3、0.5:0.5:4、0.5:0.5:5、0.6:0.1:0.6、0.6:0.1:0.7、0.6:0.1:0.8、0.6:0.1:0.9、0.6:0.1:1、0.6:0.1:2、0.6: 0.1:3, 0.6:0.1:4, 0.6:0.1:5, 0.6:0.2:0.6, 0.6:0.2:0.7, 0.6:0.2:0.8, 0.6:0.2:0.9, 0.6:0.2:1, 0.6:0.2:2, 0.6:0.2:3, 0.6:0.2:4, 0.6:0.2:5, 0.6:0.3:0.6, 0.6:0.3:0.7, 0.6:0.3:0.8, 0.6:0.3:0.9, 0.6:0.3:1, 0.6:0.3:2, 0.6:0.3:3、0.6:0.3:4、0.6:0.3:5、0.6:0.4:0.6、0.6:0.4:0.7、0.6:0.4:0.8、0.6:0.4:0.9、0.6:0.4:1、0.6:0.4:2、0.6:0.4:3、0.6:0.4:4、0.6:0.4:5、0.6:0.5:0.6、0.6:0.5:0.7、0.6:0.5:0.8、0.6:0.5:0.9、0.6:0.5:1、0.6:0.5:2、0.6:0.5:3、0.6:0.5:4、0.6:0.5:5、0.7:0.1:0.6、0.7:0.1:0.7、0.7:0.1:0.8、0.7:0.1:0.9、0.7:0.1:1、0.7:0.1:2、0.7:0.1:3、0.7:0.1:4、0.7:0.1:5、0.7:0.2:0.6、0.7:0.2:0.7、0.7:0.2:0.8、0.7:0.2:0.9、0.7:0.2:1、0.7:0.2:2、0.7:0.2:3、0.7:0.2:4、0.7:0.2:5、0.7:0.3:0.6、0.7:0.3:0.7、0.7:0.3:0.8、0.7:0.3:0.9、0.7:0.3:1、0.7:0.3:2、0.7:0.3:3、0.7:0.3:4、0.7:0.3:5、0.7:0.4:0.6、0.7:0.4:0.7、0.7:0.4:0.8、0.7:0.4:0.9、0.7:0.4:1、0.7:0.4:2、0.7:0.4:3、0.7:0.4:4、0.7:0.4:5、0.7:0.5:0.6、0.7:0.5:0.7、0.7:0.5:0.8、0.7:0.5:0.9、0.7:0.5:1、0.7:0.5:2、0.7:0.5:3、0.7:0.5:4、0.7:0.5:5、0.8:0.1:0.6、0.8:0.1:0.7、0.8:0.1:0.8、0.8:0.1:0.9、0.8:0.1:1、0.8:0.1:2、0.8:0.1:3、0.8:0.1:4、0.8:0.1:5、0.8:0.2:0.6、0.8:0.2:0.7、0.8:0.2:0.8、0.8:0.2:0.9、0.8:0.2:1、0.8:0.2:2、0.8:0.2:3、0.8:0.2:4、0.8:0.2:5、0.8:0.3:0.6、0.8:0.3:0.7、0.8:0.3:0.8、0.8:0.3:0.9、0.8:0.3:1、0.8:0.3:2、0.8:0.3:3、0.8:0.3:4、0.8:0.3:5、0.8:0.4:0.6、0.8:0.4:0.7、0.8:0.4:0.8、0.8:0.4:0.9、0.8:0.4:1、0.8:0.4:2、0.8:0.4:3、0.8:0.4:4、0.8:0.4:5、0.8:0.5:0.6、0.8:0.5:0.7、0.8:0.5:0.8、0.8:0.5:0.9、0.8:0.5:1、0.8:0.5:2、0.8:0.5:3、0.8:0.5:4、0.8:0.5:5、0.9:0.1:0.6、0.9:0.1:0.7、0.9:0.1:0.8、0.9:0.1:0.9、0.9:0.1:1、0.9:0.1:2、0.9:0.1:3、0.9:0.1:4、0.9:0.1:5、0.9:0.2:0.6、0.9:0.2:0.7、0.9:0.2:0.8、0.9:0.2:0.9、0.9:0.2:1、0.9:0.2:2、0.9:0.2:3、0.9:0.2:4、0.9:0.2:5、0.9:0.3:0.6、0.9:0.3:0.7、0.9:0.3:0.8、0.9:0.3:0.9、0.9:0.3:1、0.9:0.3:2、0.9:0.3:3、0.9:0.3:4、0.9:0.3:5、0.9:0.4:0.6、0.9:0.4:0.7、0.9:0.4:0.8、0.9:0.4:0.9、0.9:0.4:1、0.9:0.4:2、0.9:0.4:3、0.9:0.4:4、0.9:0.4:5、0.9:0.5:0.6、0.9:0.5:0.7、0.9:0.5:0.8、0.9:0.5:0.9、0.9:0.5:1、0.9:0.5:2、0.9:0.5:3、0.9:0.5:4、0.9:0.5:5、1:0.1:0.6、1:0.1:0.7、1:0.1:0.8、1:0.1:0.9、1:0.1:1、1:0.1:2、1:0.1:3、1:0.1:4、1:0.1:5、1:0.2:0.6、1:0.2:0.7、1:0.2:0.8、1:0.2:0.9、1:0.2:1、1:0.2:2、1:0.2:3、1:0.2:4、1:0.2:5、1:0.3:0.6、1:0.3:0.7、1:0.3:0.8、1:0.3:0.9、1:0.3:1、1:0.3:2、1:0.3:3、1:0.3:4、1:0.3:5、1:0.4:0.6、1:0.4:0.7、1:0.4:0.8、1:0.4:0.9、1:0.4:1、1:0.4:2、1:0.4:3、1:0.4:4、1:0.4:5、1:0.5:0.6、1:0.5:0.7、1:0.5:0.8、1:0.5:0.9、1:0.5:1、1:0.5:2、1:0.5:3、1:0.5:4、1:0.5:5、2:0.1:0.6、2:0.1:0.7、2:0.1:0.8、2:0.1:0.9、2:0.1:1、2:0.1:2、2:0.1:3、2:0.1:4、2:0.1:5、2:0.2:0.6、2:0.2:0.7、2:0.2:0.8、2:0.2:0.9、2:0.2:1、2:0.2:2、2:0.2:3、2:0.2:4、2:0.2:5、2:0.3:0.6、2:0.3:0.7、2:0.3:0.8、2:0.3:0.9、2:0.3:1、2:0.3:2、2:0.3:3、2:0.3:4、2:0.3:5、2:0.4:0.6、2:0.4:0.7、2:0.4:0.8、2:0.4:0.9、2:0.4:1、2:0.4:2、2:0.4:3、2:0.4:4、2:0.4:5、2:0.5:0.6、2:0.5:0.7、2:0.5:0.8、2:0.5:0.9、2:0.5:1、2:0.5:2、2:0.5:3、2:0.5:4、2:0.5:5、3:0.1:0.6、3:0.1:0.7、3:0.1:0.8、3:0.1:0.9、3:0.1:1、3:0.1:2、3:0.1:3、3:0.1:4、3:0.1:5、3:0.2:0.6、3:0.2:0.7、3:0.2:0.8、3:0.2:0.9、3:0.2:1、3:0.2:2、3:0.2:3、3:0.2:4、3:0.2:5、3:0.3:0.6、3:0.3:0.7、3:0.3:0.8、3:0.3:0.9、3:0.3:1、3:0.3:2、3:0.3:3、3:0.3:4、3:0.3:5、3:0.4:0.6、3:0.4:0.7、3:0.4:0.8、3:0.4:0.9、3:0.4:1、3:0.4:2、3:0.4:3、3:0.4:4、3:0.4:5、3:0.5:0.6、3:0.5:0.7、3:0.5:0.8、3:0.5:0.9、3:0.5:1、3:0.5:2、3:0.5:3、3:0.5:4、3:0.5:5、4:0.1:0.6、4:0.1:0.7、4:0.1:0.8、4:0.1:0.9、4:0.1:1、4:0.1:2、4:0.1:3、4:0.1:4、4:0.1:5、4:0.2:0.6、4:0.2:0.7、4:0.2:0.8, 4:0.2:0.9, 4:0.2:1, 4:0.2:2, 4:0.2:3, 4:0.2:4, 4:0.2:5, 4:0.3:0.6, 4:0.3:0.7, 4:0.3:0.8, 4:0.3:0.9, 4:0.3:1, 4:0.3:2, 4:0.3:3, 4:0.3:4, 4:0.3:5, 4:0.4:0.6, 4:0.4:0.7, 4:0.4:0.8, 4:0.4:0.9, 4 :0.4:1、4:0.4:2、4:0.4:3、4:0.4:4、4:0.4:5、4:0.5:0.6、4:0.5:0.7、4:0.5:0.8、4:0.5:0.9、4:0.5:1、4:0.5:2、4:0.5:3、4:0.5:4、4:0.5:5、5:0.1:0.6、5:0.1:0.7、5:0.1:0.8、5:0.1:0.9、5:0.1:1、5:0.1: 2, 5:0.1:3, 5:0.1:4, 5:0.1:5, 5:0.2:0.6, 5:0.2:0.7, 5:0.2:0.8, 5:0.2:0.9, 5:0.2:1, 5:0.2:2, 5:0.2:3, 5:0.2:4, 5:0.2:5, 5:0.3:0.6, 5:0.3:0.7, 5:0.3:0.8, 5:0.3:0.9, 5:0.3:1, 5:0.3:2, 5:0.3:3, 5:0 .3:4, 5:0.3:5, 5:0.4:0.6, 5:0.4:0.7, 5:0.4:0.8, 5:0.4:0.9, 5:0.4:1, 5:0.4:2, 5:0.4:3, 5:0.4:4, 5:0.4:5, 5:0.5:0.6, 5:0.5:0.7, 5:0.5:0.8, 5:0.5:0.9, 5:0.5:1, 5:0.5:2, 5:0.5:3, 5:0.5:4 or 5:0.5:5.

[0109] A second aspect of the present disclosure provides a dressing comprising: a base material and the aforementioned composition.

[0110] In a specific embodiment of the present disclosure, the substrate serves as a carrier of the dressing.

[0111] In a specific embodiment of the present disclosure, the substrate is or consists of absorbent fibers.

[0112] In a specific embodiment of the present disclosure, the substrate has the characteristics of soft adhesion, porous air permeability, and high liquid carrying capacity. It can be a hydrophilic fiber membrane, or it can be one or more of non-woven fabrics, gauze, fruit fiber membranes, silk membranes, Tencel membranes, bacterial cellulose membranes, trehalose membranes, chitosan membranes, and binchotan charcoal membranes.

[0113] A third aspect of the present disclosure provides a method for preparing the aforementioned composition or the aforementioned dressing, comprising the following steps:

[0114] (1) dissolving colanate in water and pre-treating the solution to obtain solution A;

[0115] (2) fully dissolving the coagulant in water to obtain solution B;

[0116] (3) mixing the dispersant and an optional preservative and fully dissolving them in water to obtain solution C;

[0117] (4) Pour solution C into solution B and stir to obtain solution D, and evenly disperse solution A in solution D;

[0118] (5) optionally adding a pH adjuster to adjust the pH to about 5 to about 7;

[0119] (6) Vacuum degassing;

[0120] (7) Packaging, sealing, and steam sterilization;

[0121] (8) Optionally, the resulting solution is loaded onto a carrier.

[0122] In a specific embodiment of the present disclosure, the pretreatment in step (1) is steam sterilization.

[0123] In a specific embodiment of the present disclosure, the temperature of the steam sterilization treatment in step (1) and / or step (7) is about 100-130°C.

[0124] In a specific embodiment of the present disclosure, the time for the steam sterilization treatment in step (1) and / or step (7) is about 10-60 minutes.

[0125] In a specific embodiment of the present disclosure, the colactic acid salt is sodium colactic acid. In some preferred embodiments, the number average molecular weight of sodium colactic acid is 400 kDa-8000 kDa.

[0126] In a specific embodiment of the present disclosure, the coagulant is selected from one or more of carbomer, kaolin and phospholipids.

[0127] According to some preferred embodiments of the present disclosure, the coagulant is carbomer.

[0128] In a specific embodiment of the present disclosure, the dispersant is one or more selected from methanol, ethanol, n-propanol, isopropanol, ethyl acetate, n-hexane and polyethylene glycol.

[0129] According to some preferred embodiments of the present disclosure, the dispersant is polyethylene glycol.

[0130] In a specific embodiment of the present disclosure, the pH adjuster is one or more selected from citric acid, tartaric acid, citric acid, malic acid, chlorogenic acid, palmitic acid, glacial acetic acid, triethanolamine, sodium hydroxide, potassium hydroxide and tromethamine.

[0131] According to some preferred embodiments of the present disclosure, the pH adjuster is tromethamine.

[0132] In a specific embodiment of the present disclosure, the preservative is one or more selected from sodium benzoate, potassium sorbate, sorbic acid and methylparaben.

[0133] According to some preferred embodiments of the present disclosure, the preservative is methylparaben.

[0134] In a specific embodiment of the present disclosure, the composition or dressing prepared by the method comprises: water, sodium colanate, carbomer, polyethylene glycol 400, tromethamine and methylparaben.

[0135] In a specific embodiment of the present disclosure, the composition or dressing prepared by the method comprises: water, sodium colanate, carbomer, glycerin, polyethylene glycol 400, xylitol, tromethamine and methylparaben.

[0136] In specific embodiments of the present disclosure, the content of the colactone salt is from about 0.5 wt % to about 5.0 wt %. In some preferred embodiments, the content of the colactone salt is from about 0.6 wt % to about 2.5 wt %. In some more preferred embodiments, the content of the colactone salt is from about 0.8 wt % to about 2.0 wt %. In some more preferred embodiments, the content of the colactone salt is from about 1.0 wt % to about 2.0 wt %. In some more preferred embodiments, the content of the colactone salt is from about 1.0 wt % to about 1.5 wt %. For example, the colanate salt may be present in an amount of about 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1.0 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2.0 wt%, 2.1 wt%, 2.2 wt%, 2.3 wt%, 2.4 wt%, 2.5 wt%, 2.6 wt%. %, 2.7wt%, 2.8wt%, 2.9wt%, 3.0wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt%, 3.8wt%, 3.9wt%, 4.0wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt% or 5.0wt%.

[0137] In a specific embodiment of the present disclosure, the content of the coagulant is about 0.1 wt % to about 0.5 wt %. In some preferred embodiments, the content of the coagulant is about 0.1 wt % to about 0.3 wt % or about 0.3 wt % to about 0.5 wt %. For example, the content of the carbomer can be about 0.1 wt %, 0.11 wt %, 0.12 wt %, 0.13 wt %, 0.14 wt %, 0.15 wt %, 0.16 wt %, 0.17 wt %, 0.18 wt %, 0.19 wt %, 0.2 wt %, 0.21 wt %, 0.22 wt %, 0.23 wt %, 0.24 wt %, 0.25 wt %, 0.26 wt %, 0.27 wt %, 0.28 wt %, 0.29 wt%, 0.3wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37wt%, 0.38wt%, 0.39wt%, 0 .4wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt% or 0.5wt%.

[0138] In a specific embodiment of the present disclosure, the content of the dispersant is about 1.0 wt % to about 5.0 wt %. In some preferred embodiments, the content of the dispersant is about 1 wt % to about 3 wt % or about 3 wt % to about 5 wt %. For example, the content of the polyethylene glycol can be about 1.0 wt %, 1.1 wt %, 1.2 wt %, 1.3 wt %, 1.4 wt %, 1.5 wt %, 1.6 wt %, 1.7 wt %, 1.8 wt %, 1.9 wt %, 2.0 wt %, 2.1 wt %, 2.2 wt %, 2.3 wt %, 2.4 wt %, 2.5 wt %, 2.6 wt %, 2.7 wt %, 2.8 wt %, 2.9 wt %, 3.0 wt %, 3.1 wt %, 3.2 wt %, 3.3 wt %, 3.4 wt %, 3.5 wt %, 3.6 wt %, 3.7 wt %, 3.8 wt %, 3.9 wt %, 4.0 wt %, 4.1 wt %, 4.2 wt %, 4.3 wt %, 4.4 wt %, 4.5 wt %, 4.6 wt %, 4.7 wt %, 4.8 wt %, 4.9 wt %, 5. 9wt%, 3.0wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt%, 3.8wt%, 3.9wt%, 4.0wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt% or 5.0wt%.

[0139] In a specific embodiment of the present disclosure, the content of the pH adjuster is about 0.1 wt % to about 0.5 wt %. In some preferred embodiments, the content of the pH adjuster is about 0.1 wt % to about 0.4 wt %. In some more preferred embodiments, the content of the pH adjuster is about 0.2 wt % to about 0.3 wt %. For example, the content of tromethamine can be about 0.1 wt %, 0.11 wt %, 0.12 wt %, 0.13 wt %, 0.14 wt %, 0.15 wt %, 0.16 wt %, 0.17 wt %, 0.18 wt %, 0.19 wt %, 0.2 wt %, 0.21 wt %, 0.22 wt %, 0.23 wt %, 0.24 wt %, 0.25 wt %, 0.26 wt %, 0.27 wt %, 0.28 wt %, 0.29 wt %, 0.30 wt %, 0.31 wt %, 0.32 wt %, 0.33 wt %, 0.34 wt %, 0.35 wt %, 0.36 wt %, 0.37 wt %, 0.38 wt %, 0.39 wt %, 0.40 wt %, 0.41 wt %, 0.42 wt %, 0.43 wt %, 0.44 wt %, 0.45 wt %, 0.46 wt %, 0.47 wt %, 0.48 wt %, 0.49 wt %, 0.50 wt %, 0.51 wt %, 0.52 wt %, 0.53 wt %, 0. 9wt%, 0.3wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37wt%, 0.38wt%, 0.39wt%, 0.4wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt% or 0.5wt%.

[0140] In a specific embodiment of the present disclosure, the content of the preservative is about 0.01wt% to about 0.1wt%. In some preferred embodiments, the content of the preservative is about 0.01wt% to 0.02wt%. For example, the content of the preservative is about 0.01wt%, 0.02wt%, 0.03wt%, 0.04wt%, 0.05wt%, 0.06wt%, 0.07wt%, 0.08wt%, 0.09wt% or 0.1wt%.

[0141] In a specific embodiment of the present disclosure, the composition or dressing prepared by the method further comprises an auxiliary agent. In some preferred embodiments, the auxiliary agent is selected from one or more of glycerol and xylitol.

[0142] In a specific embodiment of the present disclosure, the content of the auxiliary agent is about 0.5 wt % to about 15 wt %, in some preferred embodiments, the content of the auxiliary agent is about 0.5 wt % to about 5 wt %, and in some more preferred embodiments, the content of the auxiliary agent is about 0.5 wt % to about 8 wt %. For example, the content of the auxiliary agent is about 0.5 wt %, 0.6 wt %, 0.6 wt %, 0.7 wt %, 0.8 wt %, 0.9 wt %, 1 wt %, 2 wt %, 3 wt %, 4 wt %, 5 wt %, 6 wt %, 7 wt %, 8 wt %, 9 wt %, 10 wt %, 11 wt %, 12 wt %, 13 wt %, 14 wt % or 15 wt %.

[0143] In a specific embodiment of the present disclosure, the content ratio of the colactate, coagulant, and dispersant is about 0.5-5:0.1-0.5:1-5. In some preferred embodiments, the content ratio of the colactate, coagulant, and dispersant is about 0.6-2:0.1-0.5:1-5. In some more preferred embodiments, the content ratio of the colactate, coagulant, and dispersant is about 1-2:0.1-0.5:1-5. For example, the content ratio of the colanate, coagulant and dispersant may be about 0.5:0.1:0.6, 0.5:0.1:0.7, 0.5:0.1:0.8, 0.5:0.1:0.9, 0.5:0.1:1, 0.5:0.1:2, 0.5:0.1:3, 0.5:0.1:4, 0.5:0.1:5, 0.5:0.2:0.6, 0.5:0.2:0.7, 0.5:0.2:0.8, 0.5:0.2:0.9, 0.5:0.2:1, 0.5:0.2:2, 0.5:0.1:3, 0.5:0.1:4, 0.5:0.1:5, 0.5:0.2:0.6, 0.5:0.2:0.7, 0.5:0.2:0.8, 0.5:0.2:0.9, 0.5:0.2:1, 0.5:0.2:2, 0.5:0.2:3, 0.5:0.1:4, 0.5:0.1:5 .5:0.2:5、0.5:0.3:0.6、0.5:0.3:0.7、0.5:0.3:0.8、0.5:0.3:0.9、0.5:0.3:1、0.5:0.3:2、0.5:0.3:3、0.5:0.3:4、0.5:0.3:5、0.5:0.4:0.6、0.5:0.4:0.7、0.5:0.4:0.8、0.5:0.4:0.9、0.5:0.4:1、0.5:0.4:2、0.5:0.4:3、0.5:0.4:4、0.5:0.4:5、0.5:0.5: 0.6、0.5:0.5:0.7、0.5:0.5:0.8、0.5:0.5:0.9、0.5:0.5:1、0.5:0.5:2、0.5:0.5:3、0.5:0.5:4、0.5:0.5:5、0.6:0.1:0.6、0.6:0.1:0.7、0.6:0.1:0.8、0.6:0.1:0.9、0.6:0.1:1、0.6:0.1:2、0.6:0.1:3、0.6:0.1:4、0.6:0.1:5、0.6:0.2:0.6、0.6:0.2:0.7、0 .6:0.2:0.8, 0.6:0.2:0.9, 0.6:0.2:1, 0.6:0.2:2, 0.6:0.2:3, 0.6:0.2:4, 0.6:0.2:5, 0.6:0.3:0.6, 0.6:0.3:0.7, 0.6:0.3:0.8, 0.6:0.3:0.9, 0.6:0.3:1, 0.6:0.3:2, 0.6:0.3:3, 0.6:0.3:4, 0.6:0.3:5, 0.6:0.4:0.6, 0.6:0.4:0.7, 0.6:0.4:0.8, 0.6:0.4:0.9、0.6:0.4:1、0.6:0.4:2、0.6:0.4:3、0.6:0.4:4、0.6:0.4:5、0.6:0.5:0.6、0.6:0.5:0.7、0.6:0.5:0.8、0.6:0.5:0.9、0.6:0.5:1、0.6:0.5:2、0.6:0.5:3、0.6:0.5:4、0.6:0.5:5、0.7:0.1:0.6、0.7:0.1:0.7、0.7:0.1:0.8、0.7:0.1:0.9、0.7:0.1:1、0.7:0.1:2、0.7:0.1:3、0.7:0.1:4、0.7:0.1:5、0.7:0.2:0.6、0.7:0.2:0.7、0.7:0.2:0.8、0.7:0.2:0.9、0.7:0.2:1、0.7:0.2:2、0.7:0.2:3、0.7:0.2:4、0.7:0.2:5、0.7:0.3:0.6、0.7:0.3:0.7、0.7:0.3:0.8、0.7:0.3:0.9、0.7:0.3:1、0.7:0.3:2、0.7:0.3:3、0.7:0.3:4、0.7:0.3:5、0.7:0.4:0.6、0.7:0.4:0.7、0.7:0.4:0.8、0.7:0.4:0.9、0.7:0.4:1、0.7:0.4:2、0.7:0.4:3、0.7:0.4:4、0.7:0.4:5、0.7:0.5:0.6、0.7:0.5:0.7、0.7:0.5:0.8、0.7:0.5:0.9、0.7:0.5:1、0.7:0.5:2、0.7:0.5:3、0.7:0.5:4、0.7:0.5:5、0.8:0.1:0.6、0.8:0.1:0.7、0.8:0.1:0.8、0.8:0.1:0.9、0.8:0.1:1、0.8:0.1:2、0.8:0.1:3、0.8:0.1:4、0.8:0.1:5、0.8:0.2:0.6、0.8:0.2:0.7、0.8:0.2:0.8、0.8:0.2:0.9、0.8:0.2:1、0.8:0.2:2、0.8:0.2:3、0.8:0.2:4、0.8:0.2:5、0.8:0.3:0.6、0.8:0.3:0.7、0.8:0.3:0.8、0.8:0.3:0.9、0.8:0.3:1、0.8:0.3:2、0.8:0.3:3、0.8:0.3:4、0.8:0.3:5、0.8:0.4:0.6、0.8:0.4:0.7、0.8:0.4:0.8、0.8:0.4:0.9、0.8:0.4:1、0.8:0.4:2、0.8:0.4:3、0.8:0.4:4、0.8:0.4:5、0.8:0.5:0.6、0.8:0.5:0.7、0.8:0.5:0.8、0.8:0.5:0.9、0.8:0.5:1、0.8:0.5:2、0.8:0.5:3、0.8:0.5:4、0.8:0.5:5、0.9:0.1:0.6、0.9:0.1:0.7、0.9:0.1:0.8、0.9:0.1:0.9、0.9:0.1:1、0.9:0.1:2、0.9:0.1:3、0.9:0.1:4、0.9:0.1:5、0.9:0.2:0.6、0.9:0.2:0.7、0.9:0.2:0.8、0.9:0.2:0.9、0.9:0.2:1、0.9:0.2:2、0.9:0.2:3、0.9:0.2:4、0.9:0.2:5、0.9:0.3:0.6、0.9:0.3:0.7、0.9:0.3:0.8、0.9:0.3:0.9、0.9:0.3:1、0.9:0.3:2、0.9:0.3:3、0.9:0.3:4、0.9:0.3:5、0.9:0.4:0.6、0.9:0.4:0.7、0.9:0.4:0.8、0.9:0.4:0.9、0.9:0.4:1、0.9:0.4:2、0.9:0.4:3、0.9:0.4:4、0.9:0.4:5、0.9:0.5:0.6、0.9:0.5:0.7、0.9:0.5:0.8、0.9:0.5:0.9、0.9:0.5:1、0.9:0.5:2、0.9:0.5:3、0.9:0.5:4、0.9:0.5:5、1:0.1:0.6、1:0.1:0.7、1:0.1:0.8、1:0.1:0.9、1:0.1:1、1:0.1:2、1:0.1:3、1:0.1:4、1:0.1:5、1:0.2:0.6、1:0.2:0.7、1:0.2:0.8、1:0.2:0.9、1:0.2:1、1:0.2:2、1:0.2:3、1:0.2:4、1:0.2:5、1:0.3:0.6、1:0.3:0.7、1:0.3:0.8、1:0.3:0.9、1:0.3:1、1:0.3:2、1:0.3:3、1:0.3:4、1:0.3:5、1:0.4:0.6、1:0.4:0.7、1:0.4:0.8、1:0.4:0.9、1:0.4:1、1:0.4:2、1:0.4:3、1:0.4:4、1:0.4:5、1:0.5:0.6、1:0.5:0.7、1:0.5:0.8、1:0.5:0.9、1:0.5:1、1:0.5:2、1:0.5:3、1:0.5:4、1:0.5:5、2:0.1:0.6、2:0.1:0.7、2:0.1:0.8、2:0.1:0.9、2:0.1:1、2:0.1:2、2:0.1:3、2:0.1:4、2:0.1:5、2:0.2:0.6、2:0.2:0.7、2:0.2:0.8、2:0.2:0.9、2:0.2:1、2:0.2:2、2:0.2:3、2:0.2:4、2:0.2:5、2:0.3:0.6、2:0.3:0.7、2:0.3:0.8、2:0.3:0.9、2:0.3:1、2:0.3:2、2:0.3:3、2:0.3:4、2:0.3:5、2:0.4:0.6、2:0.4:0.7、2:0.4:0.8、2:0.4:0.9、2:0.4:1、2:0.4:2、2:0.4:3、2:0.4:4、2:0.4:5、2:0.5:0.6、2:0.5:0.7、2:0.5:0.8、2:0.5:0.9、2:0.5:1、2:0.5:2、2:0.5:3、2:0.5:4、2:0.5:5、3:0.1:0.6、3:0.1:0.7、3:0.1:0.8、3:0.1:0.9、3:0.1:1、3:0.1:2、3:0.1:3、3:0.1:4、3:0.1:5、3:0.2:0.6、3:0.2:0.7、3:0.2:0.8、3:0.2:0.9、3:0.2:1、3:0.2:2、3:0.2:3、3:0.2:4、3:0.2:5、3:0.3:0.6、3:0.3:0.7、3:0.3:0.8、3:0.3:0.9、3:0.3:1、3:0.3:2、3:0.3:3、3:0.3:4、3:0.3:5、3:0.4:0.6、3:0.4:0.7、3:0.4:0.8、3:0.4:0.9、3:0.4:1、3:0.4:2、3:0.4:3、3:0.4:4、3:0.4:5、3:0.5:0.6、3:0.5:0.7、3:0.5:0.8、3:0.5:0.9、3:0.5:1、3:0.5:2、3:0.5:3、3:0.5:4、3:0.5:5、4:0.1:0.6、4:0.1:0.7、4:0.1:0.8、4:0.1:0.9、4:0.1:1、4:0.1:2、4:0.1:3、4:0.1:4、4:0.1:5、4:0.2:0.6、4:0.2:0.7、4:0.2:0.8、4:0.2:0.9、4:0.2:1、4:0.2:2、4:0.2:3、4:0.2:4、4:0.2:5、4:0.3:0.6, 4:0.3:0.7, 4:0.3:0.8, 4:0.3:0.9, 4:0.3:1, 4:0.3:2, 4:0.3:3, 4:0.3:4, 4:0.3:5, 4:0.4:0.6, 4:0.4:0.7, 4:0.4:0.8, 4:0.4:0.9, 4:0.4:1, 4:0.4:2, 4:0.4:3, 4:0.4:4, 4:0.4:5, 4:0.5: 0.6, 4:0.5:0.7, 4:0.5:0.8, 4:0.5:0.9, 4:0.5:1, 4:0.5:2, 4:0.5:3, 4:0.5:4, 4:0.5:5, 5:0.1:0.6, 5:0.1:0.7, 5:0.1:0.8, 5:0.1:0.9, 5:0.1:1, 5:0.1:2, 5:0.1:3, 5:0.1:4, 5:0.1:5, 5:0. 2:0.6、5:0.2:0.7、5:0.2:0.8、5:0.2:0.9、5:0.2:1、5:0.2:2、5:0.2:3、5:0.2:4、5:0.2:5、5:0.3:0.6、5:0.3:0.7、5:0.3:0.8、5:0.3:0.9、5:0.3:1、5:0.3:2、5:0.3:3、5:0.3:4、5:0.3:5、5: 0.4:0.6, 5:0.4:0.7, 5:0.4:0.8, 5:0.4:0.9, 5:0.4:1, 5:0.4:2, 5:0.4:3, 5:0.4:4, 5:0.4:5, 5:0.5:0.6, 5:0.5:0.7, 5:0.5:0.8, 5:0.5:0.9, 5:0.5:1, 5:0.5:2, 5:0.5:3, 5:0.5:4 or 5:0.5:5.

[0144] In a specific embodiment of the present disclosure, the composition or dressing prepared by the method comprises: water, sodium colanate, carbomer, polyethylene glycol 400, tromethamine and methylparaben. The weight average molecular weight of the sodium colanate is 400 kDa-8000 kDa, and the content of the sodium colanate is about 0.5 wt % to about 5.0 wt %. In some preferred embodiments, the content of the sodium colanate is about 0.6 wt % to about 2.5 wt %. In some more preferred embodiments, the content of the sodium colanate is about 0.8 wt % to about 2.0 wt %. In some more preferred embodiments, the content of the sodium colanate is about 1.0 wt % to about 2.0 wt %. In some more preferred embodiments, the content of the sodium colanate is about 1.0 wt % to about 1.5 wt %. For example, the content of the sodium colanate can be about 0.5 wt %, 0.6 wt %, 0.7 wt %, 0.8 wt %, 0.9 wt %, 1.0 wt %, 1.1 wt %. %, 1.2wt%, 1.3wt%, 1.4wt%, 1.5wt%, 1.6wt%, 1.7wt%, 1.8wt%, 1.9wt%, 2.0wt%, 2.1wt%, 2.2wt%, 2.3wt%, 2.4wt%, 2.5wt%, 2.6wt%, 2.7wt%, 2.8wt%, 2.9wt%, 3.0wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt%, 3.8wt%, 3.9wt%, 4.0wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt% or 5.0wt%.The content of the carbomer is about 0.1wt% to about 0.5wt%. In some preferred embodiments, the content of the carbomer is about 0.1wt% to about 0.3wt% or about 0.3wt% to about 0.5wt%. For example, the content of the carbomer can be about 0.1wt%, 0.11wt%, 0.12wt%, 0.13wt%, 0.14wt%, 0.15wt%, 0.16wt%, 0.17wt%, 0.18wt%, 0.19wt%, 0.2wt%, 0.21wt%, 0.22wt%, 0.23wt%, 0.24wt%. wt%, 0.25wt%, 0.26wt%, 0.27wt%, 0.28wt%, 0.29wt%, 0.3wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37w t%, 0.38wt%, 0.39wt%, 0.4wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt% or 0.5wt%. The content of the polyethylene glycol is about 1 wt % to about 5 wt %. In some preferred embodiments, the content of the polyethylene glycol is about 1 wt % to about 3 wt % or about 3 wt % to about 5 wt %. For example, the content of the polyethylene glycol can be about 1.0 wt %, 1.1 wt %, 1.2 wt %, 1.3 wt %, 1.4 wt %, 1.5 wt %, 1.6 wt %, 1.7 wt %, 1.8 wt %, 1.9 wt %, 2.0 wt %, 2.1 wt %, 2.2 wt %, 2.3 wt %, 2.4 wt%, 2.5wt%, 2.6wt%, 2.7wt%, 2.8wt%, 2.9wt%, 3.0wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt %, 3.8wt%, 3.9wt%, 4.0wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt% or 5.0wt%.The content of the tromethamine is about 0.1wt% to about 0.5wt%, in some preferred embodiments, the content of the tromethamine is about 0.1wt% to about 0.4wt%, in some more preferred embodiments, the content of the tromethamine is about 0.2wt% to about 0.3wt%; for example, the content of the tromethamine can be about 0.1wt%, 0.11wt%, 0.12wt%, 0.13wt%, 0.14wt%, 0.15wt%, 0.16wt%, 0.17wt%, 0.18wt%, 0.19wt%, 0.2wt%, 0.21wt%, 0.22wt%, % , 0.23wt%, 0.24wt%, 0.25wt%, 0.26wt%, 0.27wt%, 0.28wt%, 0.29wt%, 0.3wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37wt%, 0.38wt%, 0.39wt%, 0.4wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt% or 0.5wt%. The content of the methylparaben is about 0.01 wt % to about 0.1 wt %. In some preferred embodiments, the content of the methylparaben is about 0.01 wt % to 0.02 wt %; for example, the content of the methylparaben is about 0.01 wt %, 0.02 wt %, 0.03 wt %, 0.04 wt %, 0.05 wt %, 0.06 wt %, 0.07 wt %, 0.08 wt %, 0.09 wt % or 0.1 wt %.

[0145] In a specific embodiment of the present disclosure, the composition or dressing prepared by the method comprises: water, sodium colanate, carbomer, glycerin, polyethylene glycol 400, xylitol, tromethamine and methylparaben. The weight average molecular weight of the sodium colanate is 400 kDa-8000 kDa, and the content of the sodium colanate is about 0.5 wt % to about 5.0 wt %. In some preferred embodiments, the content of the sodium colanate is about 0.6 wt % to about 2.5 wt %. In some more preferred embodiments, the content of the sodium colanate is about 0.8 wt % to about 2.0 wt %. In some more preferred embodiments, the content of the sodium colanate is about 1.0 wt % to about 2.0 wt %. In some more preferred embodiments, the content of the sodium colanate is about 1.0 wt % to about 1.5 wt %. For example, the content of the sodium colanate can be about 0.5 wt %, 0.6 wt %, 0.7 wt %, 0.8 wt %, 0.9 wt %, 1.0 wt %, 1.1 wt %. %, 1.2wt%, 1.3wt%, 1.4wt%, 1.5wt%, 1.6wt%, 1.7wt%, 1.8wt%, 1.9wt%, 2.0wt%, 2.1wt%, 2.2wt%, 2.3wt%, 2.4wt%, 2.5wt%, 2.6wt%, 2.7wt%, 2.8wt%, 2.9wt%, 3.0wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt%, 3.8wt%, 3.9wt%, 4.0wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt% or 5.0wt%.The content of the carbomer is about 0.1wt% to about 0.5wt%. In some preferred embodiments, the content of the carbomer is about 0.1wt% to about 0.3wt% or about 0.3wt% to about 0.5wt%. For example, the content of the carbomer can be about 0.1wt%, 0.11wt%, 0.12wt%, 0.13wt%, 0.14wt%, 0.15wt%, 0.16wt%, 0.17wt%, 0.18wt%, 0.19wt%, 0.2wt%, 0.21wt%, 0.22wt%, 0.23wt%, 0.24wt%. wt%, 0.25wt%, 0.26wt%, 0.27wt%, 0.28wt%, 0.29wt%, 0.3wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37w t%, 0.38wt%, 0.39wt%, 0.4wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt% or 0.5wt%. The content of the polyethylene glycol is about 1 wt % to about 5 wt %. In some preferred embodiments, the content of the polyethylene glycol is about 1 wt % to about 3 wt % or about 3 wt % to about 5 wt %. For example, the content of the polyethylene glycol can be about 1.0 wt %, 1.1 wt %, 1.2 wt %, 1.3 wt %, 1.4 wt %, 1.5 wt %, 1.6 wt %, 1.7 wt %, 1.8 wt %, 1.9 wt %, 2.0 wt %, 2.1 wt %, 2.2 wt %, 2.3 wt %, 2.4 wt%, 2.5wt%, 2.6wt%, 2.7wt%, 2.8wt%, 2.9wt%, 3.0wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt %, 3.8wt%, 3.9wt%, 4.0wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt% or 5.0wt%.The content of the tromethamine is about 0.1wt% to about 0.5wt%, in some preferred embodiments, the content of the tromethamine is about 0.1wt% to about 0.4wt%, in some more preferred embodiments, the content of the tromethamine is about 0.2wt% to about 0.3wt%; for example, the content of the tromethamine can be about 0.1wt%, 0.11wt%, 0.12wt%, 0.13wt%, 0.14wt%, 0.15wt%, 0.16wt%, 0.17wt%, 0.18wt%, 0.19wt%, 0.2wt%, 0.21wt%, 0.22wt%, % , 0.23wt%, 0.24wt%, 0.25wt%, 0.26wt%, 0.27wt%, 0.28wt%, 0.29wt%, 0.3wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37wt%, 0.38wt%, 0.39wt%, 0.4wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt% or 0.5wt%. The content of the methylparaben is about 0.01 wt % to about 0.1 wt %. In some preferred embodiments, the content of the methylparaben is about 0.01 wt % to 0.02 wt %; for example, the content of the methylparaben is about 0.01 wt %, 0.02 wt %, 0.03 wt %, 0.04 wt %, 0.05 wt %, 0.06 wt %, 0.07 wt %, 0.08 wt %, 0.09 wt % or 0.1 wt %.

[0146] In a specific embodiment of the present disclosure, the composition or dressing prepared by the method comprises: water, sodium colanate, carbomer, polyethylene glycol 400, tromethamine and methylparaben, wherein the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 0.5-5:0.1-0.5:1-5. In some preferred embodiments, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 0.6-2:0.1-0.5:1-5. In some more preferred embodiments, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 1-2:0.1-0.5:1-5. For example, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 can be about 0.5:0.1:0.6, 0.5:0.1:0.7, 0.5:0.1:0.8, 0.5:0.1:0.9, 0.5:0.1:1, 0.5:0.1:2, 0.5:0.1:3, 0.5:0.1:4, 0.5:0.1:5, 0.5:0.2:0.6, 0.5:0.2:0.7, 0.5:0.2:0.8, 0.5:0.2:0.9, 0.5:0.2:1, 0.5:0.2:2, 0.5:0.1:3, 0.5:0.1:4, 0.5:0.1:5, 0.5:0.2:0.6, 0.5:0.2:0.7, 0.5:0.2:0.8, 0.5:0.2:0.9, 0.5:0.2:1, 0.5:0.2:2, 0.5:0.1:3. 5:0.2:3、0.5:0.2:4、0.5:0.2:5、0.5:0.3:0.6、0.5:0.3:0.7、0.5:0.3:0.8、0.5:0.3:0.9、0.5:0.3:1、0.5:0.3:2、0.5:0.3:3、0.5:0.3:4、0.5:0.3:5、0.5:0.4:0.6、0.5:0.4:0.7、0.5:0.4:0.8、0.5:0.4:0.9、0.5:0.4:1、0.5:0.4:2、0.5 :0.4:3、0.5:0.4:4、0.5:0.4:5、0.5:0.5:0.6、0.5:0.5:0.7、0.5:0.5:0.8、0.5:0.5:0.9、0.5:0.5:1、0.5:0.5:2、0.5:0.5:3、0.5:0.5:4、0.5:0.5:5、0.6:0.1:0.6、0.6:0.1:0.7、0.6:0.1:0.8、0.6:0.1:0.9、0.6:0.1:1、0.6:0.1:2、0.6: 0.1:3, 0.6:0.1:4, 0.6:0.1:5, 0.6:0.2:0.6, 0.6:0.2:0.7, 0.6:0.2:0.8, 0.6:0.2:0.9, 0.6:0.2:1, 0.6:0.2:2, 0.6:0.2:3, 0.6:0.2:4, 0.6:0.2:5, 0.6:0.3:0.6, 0.6:0.3:0.7, 0.6:0.3:0.8, 0.6:0.3:0.9, 0.6:0.3:1, 0.6:0.3:2, 0.6:0.3:3、0.6:0.3:4、0.6:0.3:5、0.6:0.4:0.6、0.6:0.4:0.7、0.6:0.4:0.8、0.6:0.4:0.9、0.6:0.4:1、0.6:0.4:2、0.6:0.4:3、0.6:0.4:4、0.6:0.4:5、0.6:0.5:0.6、0.6:0.5:0.7、0.6:0.5:0.8、0.6:0.5:0.9、0.6:0.5:1、0.6:0.5:2、0.6:0.5:3、0.6:0.5:4、0.6:0.5:5、0.7:0.1:0.6、0.7:0.1:0.7、0.7:0.1:0.8、0.7:0.1:0.9、0.7:0.1:1、0.7:0.1:2、0.7:0.1:3、0.7:0.1:4、0.7:0.1:5、0.7:0.2:0.6、0.7:0.2:0.7、0.7:0.2:0.8、0.7:0.2:0.9、0.7:0.2:1、0.7:0.2:2、0.7:0.2:3、0.7:0.2:4、0.7:0.2:5、0.7:0.3:0.6、0.7:0.3:0.7、0.7:0.3:0.8、0.7:0.3:0.9、0.7:0.3:1、0.7:0.3:2、0.7:0.3:3、0.7:0.3:4、0.7:0.3:5、0.7:0.4:0.6、0.7:0.4:0.7、0.7:0.4:0.8、0.7:0.4:0.9、0.7:0.4:1、0.7:0.4:2、0.7:0.4:3、0.7:0.4:4、0.7:0.4:5、0.7:0.5:0.6、0.7:0.5:0.7、0.7:0.5:0.8、0.7:0.5:0.9、0.7:0.5:1、0.7:0.5:2、0.7:0.5:3、0.7:0.5:4、0.7:0.5:5、0.8:0.1:0.6、0.8:0.1:0.7、0.8:0.1:0.8、0.8:0.1:0.9、0.8:0.1:1、0.8:0.1:2、0.8:0.1:3、0.8:0.1:4、0.8:0.1:5、0.8:0.2:0.6、0.8:0.2:0.7、0.8:0.2:0.8、0.8:0.2:0.9、0.8:0.2:1、0.8:0.2:2、0.8:0.2:3、0.8:0.2:4、0.8:0.2:5、0.8:0.3:0.6、0.8:0.3:0.7、0.8:0.3:0.8、0.8:0.3:0.9、0.8:0.3:1、0.8:0.3:2、0.8:0.3:3、0.8:0.3:4、0.8:0.3:5、0.8:0.4:0.6、0.8:0.4:0.7、0.8:0.4:0.8、0.8:0.4:0.9、0.8:0.4:1、0.8:0.4:2、0.8:0.4:3、0.8:0.4:4、0.8:0.4:5、0.8:0.5:0.6、0.8:0.5:0.7、0.8:0.5:0.8、0.8:0.5:0.9、0.8:0.5:1、0.8:0.5:2、0.8:0.5:3、0.8:0.5:4、0.8:0.5:5、0.9:0.1:0.6、0.9:0.1:0.7、0.9:0.1:0.8、0.9:0.1:0.9、0.9:0.1:1、0.9:0.1:2、0.9:0.1:3、0.9:0.1:4、0.9:0.1:5、0.9:0.2:0.6、0.9:0.2:0.7、0.9:0.2:0.8、0.9:0.2:0.9、0.9:0.2:1、0.9:0.2:2、0.9:0.2:3、0.9:0.2:4、0.9:0.2:5、0.9:0.3:0.6、0.9:0.3:0.7、0.9:0.3:0.8、0.9:0.3:0.9、0.9:0.3:1、0.9:0.3:2、0.9:0.3:3、0.9:0.3:4、0.9:0.3:5、0.9:0.4:0.6、0.9:0.4:0.7、0.9:0.4:0.8、0.9:0.4:0.9、0.9:0.4:1、0.9:0.4:2、0.9:0.4:3、0.9:0.4:4、0.9:0.4:5、0.9:0.5:0.6、0.9:0.5:0.7、0.9:0.5:0.8、0.9:0.5:0.9、0.9:0.5:1、0.9:0.5:2、0.9:0.5:3、0.9:0.5:4、0.9:0.5:5、1:0.1:0.6、1:0.1:0.7、1:0.1:0.8、1:0.1:0.9、1:0.1:1、1:0.1:2、1:0.1:3、1:0.1:4、1:0.1:5、1:0.2:0.6、1:0.2:0.7、1:0.2:0.8、1:0.2:0.9、1:0.2:1、1:0.2:2、1:0.2:3、1:0.2:4、1:0.2:5、1:0.3:0.6、1:0.3:0.7、1:0.3:0.8、1:0.3:0.9、1:0.3:1、1:0.3:2、1:0.3:3、1:0.3:4、1:0.3:5、1:0.4:0.6、1:0.4:0.7、1:0.4:0.8、1:0.4:0.9、1:0.4:1、1:0.4:2、1:0.4:3、1:0.4:4、1:0.4:5、1:0.5:0.6、1:0.5:0.7、1:0.5:0.8、1:0.5:0.9、1:0.5:1、1:0.5:2、1:0.5:3、1:0.5:4、1:0.5:5、2:0.1:0.6、2:0.1:0.7、2:0.1:0.8、2:0.1:0.9、2:0.1:1、2:0.1:2、2:0.1:3、2:0.1:4、2:0.1:5、2:0.2:0.6、2:0.2:0.7、2:0.2:0.8、2:0.2:0.9、2:0.2:1、2:0.2:2、2:0.2:3、2:0.2:4、2:0.2:5、2:0.3:0.6、2:0.3:0.7、2:0.3:0.8、2:0.3:0.9、2:0.3:1、2:0.3:2、2:0.3:3、2:0.3:4、2:0.3:5、2:0.4:0.6、2:0.4:0.7、2:0.4:0.8、2:0.4:0.9、2:0.4:1、2:0.4:2、2:0.4:3、2:0.4:4、2:0.4:5、2:0.5:0.6、2:0.5:0.7、2:0.5:0.8、2:0.5:0.9、2:0.5:1、2:0.5:2、2:0.5:3、2:0.5:4、2:0.5:5、3:0.1:0.6、3:0.1:0.7、3:0.1:0.8、3:0.1:0.9、3:0.1:1、3:0.1:2、3:0.1:3、3:0.1:4、3:0.1:5、3:0.2:0.6、3:0.2:0.7、3:0.2:0.8、3:0.2:0.9、3:0.2:1、3:0.2:2、3:0.2:3、3:0.2:4、3:0.2:5、3:0.3:0.6、3:0.3:0.7、3:0.3:0.8、3:0.3:0.9、3:0.3:1、3:0.3:2、3:0.3:3、3:0.3:4、3:0.3:5、3:0.4:0.6、3:0.4:0.7、3:0.4:0.8、3:0.4:0.9、3:0.4:1、3:0.4:2、3:0.4:3、3:0.4:4、3:0.4:5、3:0.5:0.6、3:0.5:0.7、3:0.5:0.8、3:0.5:0.9、3:0.5:1、3:0.5:2、3:0.5:3、3:0.5:4、3:0.5:5、4:0.1:0.6、4:0.1:0.7、4:0.1:0.8、4:0.1:0.9、4:0.1:1、4:0.1:2、4:0.1:3、4:0.1:4、4:0.1:5、4:0.2:0.6、4:0.2:0.7、4:0.2:0.8, 4:0.2:0.9, 4:0.2:1, 4:0.2:2, 4:0.2:3, 4:0.2:4, 4:0.2:5, 4:0.3:0.6, 4:0.3:0.7, 4:0.3:0.8, 4:0.3:0.9, 4:0.3:1, 4:0.3:2, 4:0.3:3, 4:0.3:4, 4:0.3:5, 4:0.4:0.6, 4:0.4:0.7, 4:0.4:0.8, 4:0.4:0.9, 4 :0.4:1、4:0.4:2、4:0.4:3、4:0.4:4、4:0.4:5、4:0.5:0.6、4:0.5:0.7、4:0.5:0.8、4:0.5:0.9、4:0.5:1、4:0.5:2、4:0.5:3、4:0.5:4、4:0.5:5、5:0.1:0.6、5:0.1:0.7、5:0.1:0.8、5:0.1:0.9、5:0.1:1、5:0.1: 2, 5:0.1:3, 5:0.1:4, 5:0.1:5, 5:0.2:0.6, 5:0.2:0.7, 5:0.2:0.8, 5:0.2:0.9, 5:0.2:1, 5:0.2:2, 5:0.2:3, 5:0.2:4, 5:0.2:5, 5:0.3:0.6, 5:0.3:0.7, 5:0.3:0.8, 5:0.3:0.9, 5:0.3:1, 5:0.3:2, 5:0.3:3, 5:0 .3:4, 5:0.3:5, 5:0.4:0.6, 5:0.4:0.7, 5:0.4:0.8, 5:0.4:0.9, 5:0.4:1, 5:0.4:2, 5:0.4:3, 5:0.4:4, 5:0.4:5, 5:0.5:0.6, 5:0.5:0.7, 5:0.5:0.8, 5:0.5:0.9, 5:0.5:1, 5:0.5:2, 5:0.5:3, 5:0.5:4 or 5:0.5:5.

[0147] In a specific embodiment of the present disclosure, the composition or dressing prepared by the method comprises: water, sodium colanate, carbomer, glycerin, polyethylene glycol 400, xylitol, tromethamine and methylparaben, wherein the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 0.5-5:0.1-0.5:1-5. In some preferred embodiments, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 0.6-2:0.1-0.5:1-5. In some more preferred embodiments, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 1-2:0.1-0.5:1-5. For example, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 can be about 0.5:0.1:0.6, 0.5:0.1:0.7, 0.5:0.1:0.8, 0.5:0.1:0.9, 0.5:0.1:1, 0.5:0.1:2, 0.5:0.1:3, 0.5:0.1:4, 0.5:0.1:5, 0.5:0.2:0.6, 0.5:0.2:0.7, 0.5:0.2:0.8, 0.5:0.2:0.9, 0.5:0.2:1, 0.5:0.2:2. 、0.5:0.2:3、0.5:0.2:4、0.5:0.2:5、0.5:0.3:0.6、0.5:0.3:0.7、0.5:0.3:0.8、0.5:0.3:0.9、0.5:0.3:1、0.5:0.3:2、0.5:0.3:3、0.5:0.3:4、0.5:0.3:5、0.5:0.4:0.6、0.5:0.4:0.7、0.5:0.4:0.8、0.5:0.4:0.9、0.5:0.4:1、0.5:0.4: 2, 0.5:0.4:3, 0.5:0.4:4, 0.5:0.4:5, 0.5:0.5:0.6, 0.5:0.5:0.7, 0.5:0.5:0.8, 0.5:0.5:0.9, 0.5:0.5:1, 0.5:0.5:2, 0.5:0.5:3, 0.5:0.5:4, 0.5:0.5:5, 0.6:0.1:0.6, 0.6:0.1:0.7, 0.6:0.1:0.8, 0.6:0.1:0.9, 0.6:0.1:1, 0.6:0.1 :2, 0.6:0.1:3, 0.6:0.1:4, 0.6:0.1:5, 0.6:0.2:0.6, 0.6:0.2:0.7, 0.6:0.2:0.8, 0.6:0.2:0.9, 0.6:0.2:1, 0.6:0.2:2, 0.6:0.2:3, 0.6:0.2:4, 0.6:0.2:5, 0.6:0.3:0.6, 0.6:0.3:0.7, 0.6:0.3:0.8, 0.6:0.3:0.9, 0.6:0.3:1, 0.6:0.3:2、0.6:0.3:3、0.6:0.3:4、0.6:0.3:5、0.6:0.4:0.6、0.6:0.4:0.7、0.6:0.4:0.8、0.6:0.4:0.9、0.6:0.4:1、0.6:0.4:2、0.6:0.4:3、0.6:0.4:4、0.6:0.4:5、0.6:0.5:0.6、0.6:0.5:0.7、0.6:0.5:0.8、0.6:0.5:0.9、0.6:0.5:1、0.6:0.5:2、0.6:0.5:3、0.6:0.5:4、0.6:0.5:5、0.7:0.1:0.6、0.7:0.1:0.7、0.7:0.1:0.8、0.7:0.1:0.9、0.7:0.1:1、0.7:0.1:2、0.7:0.1:3、0.7:0.1:4、0.7:0.1:5、0.7:0.2:0.6、0.7:0.2:0.7、0.7:0.2:0.8、0.7:0.2:0.9、0.7:0.2:1、0.7:0.2:2、0.7:0.2:3、0.7:0.2:4、0.7:0.2:5、0.7:0.3:0.6、0.7:0.3:0.7、0.7:0.3:0.8、0.7:0.3:0.9、0.7:0.3:1、0.7:0.3:2、0.7:0.3:3、0.7:0.3:4、0.7:0.3:5、0.7:0.4:0.6、0.7:0.4:0.7、0.7:0.4:0.8、0.7:0.4:0.9、0.7:0.4:1、0.7:0.4:2、0.7:0.4:3、0.7:0.4:4、0.7:0.4:5、0.7:0.5:0.6、0.7:0.5:0.7、0.7:0.5:0.8、0.7:0.5:0.9、0.7:0.5:1、0.7:0.5:2、0.7:0.5:3、0.7:0.5:4、0.7:0.5:5、0.8:0.1:0.6、0.8:0.1:0.7、0.8:0.1:0.8、0.8:0.1:0.9、0.8:0.1:1、0.8:0.1:2、0.8:0.1:3、0.8:0.1:4、0.8:0.1:5、0.8:0.2:0.6、0.8:0.2:0.7、0.8:0.2:0.8、0.8:0.2:0.9、0.8:0.2:1、0.8:0.2:2、0.8:0.2:3、0.8:0.2:4、0.8:0.2:5、0.8:0.3:0.6、0.8:0.3:0.7、0.8:0.3:0.8、0.8:0.3:0.9、0.8:0.3:1、0.8:0.3:2、0.8:0.3:3、0.8:0.3:4、0.8:0.3:5、0.8:0.4:0.6、0.8:0.4:0.7、0.8:0.4:0.8、0.8:0.4:0.9、0.8:0.4:1、0.8:0.4:2、0.8:0.4:3、0.8:0.4:4、0.8:0.4:5、0.8:0.5:0.6、0.8:0.5:0.7、0.8:0.5:0.8、0.8:0.5:0.9、0.8:0.5:1、0.8:0.5:2、0.8:0.5:3、0.8:0.5:4、0.8:0.5:5、0.9:0.1:0.6、0.9:0.1:0.7、0.9:0.1:0.8、0.9:0.1:0.9、0.9:0.1:1、0.9:0.1:2、0.9:0.1:3、0.9:0.1:4、0.9:0.1:5、0.9:0.2:0.6、0.9:0.2:0.7、0.9:0.2:0.8、0.9:0.2:0.9、0.9:0.2:1、0.9:0.2:2、0.9:0.2:3、0.9:0.2:4、0.9:0.2:5、0.9:0.3:0.6、0.9:0.3:0.7、0.9:0.3:0.8、0.9:0.3:0.9、0.9:0.3:1、0.9:0.3:2、0.9:0.3:3、0.9:0.3:4、0.9:0.3:5、0.9:0.4:0.6、0.9:0.4:0.7、0.9:0.4:0.8、0.9:0.4:0.9、0.9:0.4:1、0.9:0.4:2、0.9:0.4:3、0.9:0.4:4、0.9:0.4:5、0.9:0.5:0.6、0.9:0.5:0.7、0.9:0.5:0.8、0.9:0.5:0.9、0.9:0.5:1、0.9:0.5:2、0.9:0.5:3、0.9:0.5:4、0.9:0.5:5、1:0.1:0.6、1:0.1:0.7、1:0.1:0.8、1:0.1:0.9、1:0.1:1、1:0.1:2、1:0.1:3、1:0.1:4、1:0.1:5、1:0.2:0.6、1:0.2:0.7、1:0.2:0.8、1:0.2:0.9、1:0.2:1、1:0.2:2、1:0.2:3、1:0.2:4、1:0.2:5、1:0.3:0.6、1:0.3:0.7、1:0.3:0.8、1:0.3:0.9、1:0.3:1、1:0.3:2、1:0.3:3、1:0.3:4、1:0.3:5、1:0.4:0.6、1:0.4:0.7、1:0.4:0.8、1:0.4:0.9、1:0.4:1、1:0.4:2、1:0.4:3、1:0.4:4、1:0.4:5、1:0.5:0.6、1:0.5:0.7、1:0.5:0.8、1:0.5:0.9、1:0.5:1、1:0.5:2、1:0.5:3、1:0.5:4、1:0.5:5、2:0.1:0.6、2:0.1:0.7、2:0.1:0.8、2:0.1:0.9、2:0.1:1、2:0.1:2、2:0.1:3、2:0.1:4、2:0.1:5、2:0.2:0.6、2:0.2:0.7、2:0.2:0.8、2:0.2:0.9、2:0.2:1、2:0.2:2、2:0.2:3、2:0.2:4、2:0.2:5、2:0.3:0.6、2:0.3:0.7、2:0.3:0.8、2:0.3:0.9、2:0.3:1、2:0.3:2、2:0.3:3、2:0.3:4、2:0.3:5、2:0.4:0.6、2:0.4:0.7、2:0.4:0.8、2:0.4:0.9、2:0.4:1、2:0.4:2、2:0.4:3、2:0.4:4、2:0.4:5、2:0.5:0.6、2:0.5:0.7、2:0.5:0.8、2:0.5:0.9、2:0.5:1、2:0.5:2、2:0.5:3、2:0.5:4、2:0.5:5、3:0.1:0.6、3:0.1:0.7、3:0.1:0.8、3:0.1:0.9、3:0.1:1、3:0.1:2、3:0.1:3、3:0.1:4、3:0.1:5、3:0.2:0.6、3:0.2:0.7、3:0.2:0.8、3:0.2:0.9、3:0.2:1、3:0.2:2、3:0.2:3、3:0.2:4、3:0.2:5、3:0.3:0.6、3:0.3:0.7、3:0.3:0.8、3:0.3:0.9、3:0.3:1、3:0.3:2、3:0.3:3、3:0.3:4、3:0.3:5、3:0.4:0.6、3:0.4:0.7、3:0.4:0.8、3:0.4:0.9、3:0.4:1、3:0.4:2、3:0.4:3、3:0.4:4、3:0.4:5、3:0.5:0.6、3:0.5:0.7、3:0.5:0.8、3:0.5:0.9、3:0.5:1、3:0.5:2、3:0.5:3、3:0.5:4、3:0.5:5、4:0.1:0.6、4:0.1:0.7、4:0.1:0.8、4:0.1:0.9、4:0.1:1、4:0.1:2、4:0.1:3、4:0.1:4、4:0.1:5、4:0.2:0.6、4:0.2:0.7, 4:0.2:0.8, 4:0.2:0.9, 4:0.2:1, 4:0.2:2, 4:0.2:3, 4:0.2:4, 4:0.2:5, 4:0.3:0.6, 4:0.3:0.7, 4:0.3:0.8, 4:0.3:0.9, 4:0.3:1, 4:0.3:2, 4:0.3:3, 4:0.3:4, 4:0.3:5, 4:0.4:0.6, 4:0.4:0.7, 4:0.4:0.8, 4:0 .4:0.9, 4:0.4:1, 4:0.4:2, 4:0.4:3, 4:0.4:4, 4:0.4:5, 4:0.5:0.6, 4:0.5:0.7, 4:0.5:0.8, 4:0.5:0.9, 4:0.5:1, 4:0.5:2, 4:0.5:3, 4:0.5:4, 4:0.5:5, 5:0.1:0.6, 5:0.1:0.7, 5:0.1:0.8, 5:0.1:0.9, 5:0.1:1, 5 :0.1:2、5:0.1:3、5:0.1:4、5:0.1:5、5:0.2:0.6、5:0.2:0.7、5:0.2:0.8、5:0.2:0.9、5:0.2:1、5:0.2:2、5:0.2:3、5:0.2:4、5:0.2:5、5:0.3:0.6、5:0.3:0.7、5:0.3:0.8、5:0.3:0.9、5:0.3:1、5:0.3:2、5:0.3:3、 5:0.3:4, 5:0.3:5, 5:0.4:0.6, 5:0.4:0.7, 5:0.4:0.8, 5:0.4:0.9, 5:0.4:1, 5:0.4:2, 5:0.4:3, 5:0.4:4, 5:0.4:5, 5:0.5:0.6, 5:0.5:0.7, 5:0.5:0.8, 5:0.5:0.9, 5:0.5:1, 5:0.5:2, 5:0.5:3, 5:0.5:4 or 5:0.5:5.

[0148] A fourth aspect of the present disclosure provides use of the aforementioned composition or the aforementioned dressing in preparing a product for aftercare of light medical aesthetics.

[0149] In a specific embodiment of the present disclosure, the product is a cosmetic or a medical dressing.

[0150] In a specific embodiment of the present disclosure, the aforementioned composition or dressing is used after a patient undergoes aesthetic medical treatment.

[0151] Example

[0152] The following examples are illustrative only and are not intended to limit the scope or content of the invention in any way.

[0153] Example 1

[0154] This example provides a sodium colanate repair dressing. It comprises 1.0 wt% sodium colanate, 0.1 wt% carbomer, 3.0 wt% polyethylene glycol 400, 0.3 wt% tromethamine, 0.01 wt% methylparaben, and the balance water. The ratio of sodium colanate: carbomer: polyethylene glycol 400 is 1:0.1:3. The weight-average molecular weight of sodium colanate is 400 kDa. The preparation steps are as follows: Weigh sodium colanate, dissolve it in purified water, and place it in a steam sterilizer for pretreatment to remove endotoxins at 121°C for 30 minutes to obtain solution 1. Weigh carbomer, add it to a vacuum stirring tank, add purified water, heat at 80°C for 10 minutes, and mechanically stir until fully dissolved at 300 rpm to obtain solution 2. Weigh polyethylene glycol 400 and methylparaben, add them to purified water, and mechanically stir at room temperature at 300 rpm until fully dissolved to obtain solution 3. Pour Solution 3 into Solution 2 and mechanically stir in a vacuum stirring tank until uniform. Then slowly add Solution 1. Add tromethamine gradually to adjust the pH to 7. Vacuum degassing is performed to obtain the sodium colanate repair dressing. The sodium colanate repair dressing is packaged, sealed, and steam sterilized (121°C, 30 minutes).

[0155] Example 2

[0156] This example provides a sodium colanate repair dressing. It comprises 1.0 wt% sodium colanate, 0.3 wt% carbomer, 3.0 wt% polyethylene glycol 400, 0.3 wt% tromethamine, 0.01 wt% methylparaben, and the balance water. The ratio of sodium colanate: carbomer: polyethylene glycol 400 is 1:0.3:3. The weight-average molecular weight of sodium colanate is 400 kDa. The preparation steps are as follows: Weigh sodium colanate, dissolve it in purified water, and place it in a steam sterilizer for pretreatment to remove endotoxins at 121°C for 30 minutes to obtain solution 1. Weigh carbomer, add it to a vacuum stirring tank, add purified water, heat at 80°C for 10 minutes, and mechanically stir until fully dissolved at 300 rpm to obtain solution 2. Weigh polyethylene glycol 400 and methylparaben, add them to purified water, and mechanically stir at room temperature at 300 rpm until fully dissolved to obtain solution 3. Solution 3 was poured into Solution 2 and mechanically stirred in a vacuum stirring tank. Solution 1 was then slowly added. Tromethamine was then added gradually to adjust the pH to 7. After vacuum degassing, a sodium colanate repair dressing was obtained. The sodium colanate repair dressing was packaged, sealed, and steam sterilized (121°C, 30 minutes). Example 2 differs from Example 1 in that the carbomer ratio was adjusted to 0.3 wt%. The remaining components and preparation methods were the same.

[0157] Example 3

[0158] This example provides a sodium colanate repair dressing. It comprises 1.0 wt% sodium colanate, 0.5 wt% carbomer, 3.0 wt% polyethylene glycol 400, 0.3 wt% tromethamine, 0.01 wt% methylparaben, and the balance water. The ratio of sodium colanate: carbomer: polyethylene glycol 400 is 1:0.5:3. The weight-average molecular weight of sodium colanate is 400 kDa. The preparation steps are as follows: Weigh sodium colanate, dissolve it in purified water, and pre-treat it in a steam sterilizer to remove endotoxins at 121°C for 30 minutes to obtain solution 1. Weigh carbomer and add it to a vacuum stirring tank, add purified water, heat at 80°C for 10 minutes, and mechanically stir until fully dissolved at 300 rpm to obtain solution 2. Weigh polyethylene glycol 400 and methylparaben, add them to purified water, and mechanically stir at room temperature at 300 rpm until fully dissolved to obtain solution 3. Solution 3 was poured into Solution 2 and mechanically stirred in a vacuum stirring tank. Solution 1 was then slowly added. Tromethamine was then added gradually to adjust the pH to 7. After vacuum degassing, a sodium colanate repair dressing was obtained. The sodium colanate repair dressing was packaged, sealed, and steam sterilized (121°C, 30 minutes). Example 3 differs from Example 1 in that the carbomer ratio was adjusted to 0.5 wt%. The remaining components and preparation methods were the same.

[0159] Example 4

[0160] This example provides a sodium colanate repair dressing. It comprises 1.0 wt% sodium colanate, 0.1 wt% carbomer, 1.0 wt% polyethylene glycol 400, 0.3 wt% tromethamine, 0.01 wt% methylparaben, and the balance water. The ratio of sodium colanate: carbomer: polyethylene glycol 400 is 1:0.1:1. The weight-average molecular weight of sodium colanate is 400 kDa. The preparation steps are as follows: Weigh sodium colanate, dissolve it in purified water, and place it in a steam sterilizer for pretreatment to remove endotoxins at 121°C for 30 minutes to obtain solution 1. Weigh carbomer, add it to a vacuum stirring tank, add purified water, heat at 80°C for 10 minutes, and mechanically stir until fully dissolved at 300 rpm to obtain solution 2. Weigh polyethylene glycol 400 and methylparaben, add them to purified water, and mechanically stir at room temperature at 300 rpm until fully dissolved to obtain solution 3. Solution 3 was poured into Solution 2 and mechanically stirred in a vacuum stirring tank. Solution 1 was then slowly added. Tromethamine was then added gradually to adjust the pH to 7. After vacuum degassing, a sodium colanate repair dressing was obtained. The sodium colanate repair dressing was packaged, sealed, and steam sterilized (121°C, 30 minutes). Example 4 differs from Example 1 in that the proportion of polyethylene glycol 400 was adjusted to 1.0 wt%. The remaining components and preparation method were the same.

[0161] Example 5

[0162] This example provides a sodium colanate repair dressing. It comprises 1.0 wt% sodium colanate, 0.1 wt% carbomer, 5.0 wt% polyethylene glycol 400, 0.3 wt% tromethamine, 0.01 wt% methylparaben, and the balance water. The ratio of sodium colanate: carbomer: polyethylene glycol 400 is 1:0.1:5. The weight-average molecular weight of sodium colanate is 400 kDa. The preparation steps are as follows: Weigh sodium colanate, dissolve it in purified water, and pre-treat it in a steam sterilizer to remove endotoxins at 121°C for 30 minutes to obtain solution 1. Weigh carbomer, add it to a vacuum stirring tank, add purified water, heat at 80°C for 10 minutes, and mechanically stir until fully dissolved at 300 rpm to obtain solution 2. Weigh polyethylene glycol 400 and methylparaben, add them to purified water, and mechanically stir them at room temperature at 300 rpm until fully dissolved to obtain solution 3. Solution 3 was poured into Solution 2 and mechanically stirred in a vacuum stirring tank. Solution 1 was then slowly added. Tromethamine was then added gradually to adjust the pH to 7. After vacuum degassing, a sodium colanate repair dressing was obtained. The sodium colanate repair dressing was packaged, sealed, and steam sterilized (121°C, 30 minutes). Example 5 differs from Example 1 in that the carbomer ratio is increased to 5.0 wt%. The remaining components and preparation method are the same.

[0163] Example 6

[0164] This example provides a sodium colanate repair dressing. It comprises 1.0 wt% sodium colanate, 0.1 wt% carbomer, 3.0 wt% polyethylene glycol 400, 0.3 wt% tromethamine, 0.01 wt% methylparaben, and the balance water. The ratio of sodium colanate: carbomer: polyethylene glycol 400 is 1:0.1:3. The weight-average molecular weight of sodium colanate is 8000 kDa. The preparation steps are as follows: Weigh sodium colanate, dissolve it in purified water, and place it in a steam sterilizer for pretreatment to remove endotoxins at 121°C for 30 minutes to obtain solution 1. Weigh carbomer, add it to a vacuum stirring tank, add purified water, heat at 80°C for 10 minutes, and mechanically stir until fully dissolved at 300 rpm to obtain solution 2. Weigh polyethylene glycol 400 and methylparaben, add them to purified water, and mechanically stir at room temperature at 300 rpm until fully dissolved to obtain solution 3. Solution 3 was poured into Solution 2 and mechanically stirred in a vacuum stirring tank. Solution 1 was then slowly added. Tromethamine was then added gradually to adjust the pH to 7. After vacuum degassing, a sodium colanate repair dressing was obtained. The sodium colanate repair dressing was packaged, sealed, and steam sterilized (121°C, 30 minutes). Example 6 differs from Example 1 in that the molecular weight of sodium colanate is 8000 kDa. The remaining components and preparation methods are the same.

[0165] Example 7

[0166] This embodiment provides a sodium colanate repair dressing. It comprises 2.0 wt% sodium colanate, 0.1 wt% carbomer, 3.0 wt% polyethylene glycol 400, 0.3 wt% tromethamine, 0.01 wt% methylparaben, and the balance water. The ratio of sodium colanate: carbomer: polyethylene glycol 400 is 2:0.1:3. The weight-average molecular weight of sodium colanate is 400 kDa. The preparation steps are as follows: Weigh sodium colanate, dissolve it in purified water, and place it in a steam sterilizer for pretreatment to remove endotoxins at 121°C for 30 minutes to obtain solution 1. Weigh carbomer, add it to a vacuum stirring tank, add purified water, heat at 80°C for 10 minutes, and mechanically stir until fully dissolved at a stirring speed of 300 rpm to obtain solution 2. Weigh polyethylene glycol 400 and methylparaben, add them to purified water, and mechanically stir them at room temperature at a stirring speed of 300 rpm until fully dissolved to obtain solution 3. Solution 3 was poured into Solution 2 and mechanically stirred in a vacuum stirring tank. Solution 1 was then slowly added. Tromethamine was then added gradually to adjust the pH to 7. After vacuum degassing, a sodium colanate repair dressing was obtained. The sodium colanate repair dressing was packaged, sealed, and steam sterilized (121°C, 30 minutes). Example 7 differs from Example 1 in that the sodium colanate ratio was adjusted to 2.0 wt%. The remaining components and preparation method were the same.

[0167] Example 8

[0168] This embodiment provides a sodium colanate repair dressing. It comprises 1.0 wt% sodium colanate, 0.1 wt% carbomer, 3.0 wt% polyethylene glycol 400, 0.2 wt% tromethamine, 0.02 wt% methylparaben, and the balance water. The ratio of sodium colanate: carbomer: polyethylene glycol 400 is 1:0.1:3. The weight-average molecular weight of sodium colanate is 400 kDa. The preparation steps are as follows: Weigh sodium colanate, dissolve it in purified water, and place it in a steam sterilizer for pretreatment to remove endotoxins at 121°C for 30 minutes to obtain solution 1. Weigh carbomer, add it to a vacuum stirring tank, add purified water, heat at 80°C for 10 minutes, and mechanically stir until fully dissolved at a stirring speed of 300 rpm to obtain solution 2. Weigh polyethylene glycol 400 and methylparaben, add them to purified water, and mechanically stir them at room temperature at a stirring speed of 300 rpm until fully dissolved to obtain solution 3. Solution 3 was poured into Solution 2 and mechanically stirred in a vacuum stirring tank. Solution 1 was then slowly added. Tromethamine was then added gradually to adjust the pH to 7. After vacuum degassing, a sodium colanate repair dressing was obtained. The sodium colanate repair dressing was packaged, sealed, and steam sterilized (121°C, 30 minutes). Example 8 differs from Example 1 in that the ratio of tromethamine to methylparaben was appropriately adjusted. The remaining components and preparation methods were the same.

[0169] Comparative Example 1

[0170] This comparative example provides a sodium hyaluronate repair dressing. It comprises 1.0 wt% sodium hyaluronate, 0.1 wt% carbomer, 3.0 wt% polyethylene glycol 400, 0.3 wt% tromethamine, 0.01 wt% methylparaben, and the balance water. The ratio of sodium hyaluronate:carbomer:polyethylene glycol 400 is 1:0.1:3. The weight-average molecular weight of sodium hyaluronate is 100 kDa. The preparation steps are as follows: Weigh sodium hyaluronate, dissolve it in purified water, and place it in a steam sterilizer for pretreatment to remove endotoxins at 121°C for 30 minutes to obtain solution 1. Weigh carbomer and add it to a vacuum stirring tank, add purified water, heat at 80°C for 10 minutes, and mechanically stir until fully dissolved at 300 rpm to obtain solution 2. Weigh polyethylene glycol 400 and methylparaben, add them to purified water, and mechanically stir at room temperature at 300 rpm until fully dissolved to obtain solution 3. Solution 3 was poured into solution 2, mechanically stirred in a vacuum stirring tank, and then solution 1 was slowly added. Tromethamine was then added gradually to adjust the pH to 7, and a sodium hyaluronate repair dressing was obtained after vacuum degassing. The sodium hyaluronate repair dressing was packaged, sealed, and then steam sterilized. Comparative Example 1 differs from Example 1 in that sodium hyaluronate was used instead of sodium colanate, and the remaining components and preparation methods were the same. Sodium hyaluronate was purchased as an external reagent.

[0171] Comparative Example 2

[0172] This comparative example provides a sodium colanate repair dressing. It comprises 1.0 wt% sodium colanate, 0.1 wt% carbomer, 3.0 wt% polyethylene glycol 400, 0.3 wt% tromethamine, 0.01 wt% methylparaben, and the balance water. The ratio of sodium colanate: carbomer: polyethylene glycol 400 is 1:0.1:3. The weight-average molecular weight of sodium colanate is 400 kDa. The preparation steps are as follows: Weigh sodium colanate, dissolve it in purified water, and pre-treat it in a steam sterilizer to remove endotoxins at 121°C for 5 minutes to obtain Solution 1. Weigh carbomer, add it to a vacuum stirring tank, add purified water, heat at 80°C for 10 minutes, and mechanically stir until fully dissolved at 300 rpm to obtain Solution 2. Weigh polyethylene glycol 400 and methylparaben, add them to purified water, and mechanically stir them at room temperature at 300 rpm until fully dissolved to obtain Solution 3. Solution 3 was poured into Solution 2 and mechanically stirred in a vacuum stirring tank until uniform. Solution 1 was then slowly added. Tromethamine was then added gradually to adjust the pH to 7. After vacuum degassing, a sodium colanate repair dressing was obtained. The sodium colanate repair dressing was packaged, sealed, and then steam sterilized. Comparative Example 2 differs from Example 1 in that the steam pretreatment time was 5 minutes. The remaining components and preparation methods were the same.

[0173] Comparative Example 3

[0174] This comparative example provides a sodium colanate repair dressing. It comprises 1.0 wt% sodium colanate, 0.0 wt% carbomer, 3.0 wt% polyethylene glycol 400, 0.3 wt% tromethamine, 0.01 wt% methylparaben, and the balance water. The ratio of sodium colanate: carbomer: polyethylene glycol 400 is 1:0:3. The weight-average molecular weight of sodium colanate is 400 kDa. The preparation steps are as follows: Weigh sodium colanate, dissolve it in purified water, and pre-treat it in a steam sterilizer to remove endotoxins at 121°C for 30 minutes to obtain Solution 1. Weigh carbomer, add it to a vacuum stirring tank, add purified water, heat at 80°C for 10 minutes, and mechanically stir until fully dissolved at 300 rpm to obtain Solution 2. Weigh polyethylene glycol 400 and methylparaben, add them to purified water, and mechanically stir them at room temperature at 300 rpm until fully dissolved to obtain Solution 3. Solution 3 was poured into Solution 2 and mechanically stirred in a vacuum stirring tank until uniform. Solution 1 was then slowly added. Tromethamine was then added gradually to adjust the pH to 7. After vacuum degassing, a sodium colanate repair dressing was obtained. The sodium colanate repair dressing was packaged, sealed, and steam sterilized. Comparative Example 3 differs from Example 1 in that the carbomer content was 0.0 wt%. The remaining components and preparation method were the same.

[0175] Comparative Example 4

[0176] This comparative example provides a sodium colanate repair dressing. It comprises 1.0 wt% sodium colanate, 0.1 wt% carbomer, 0.0 wt% polyethylene glycol 400, 0.3 wt% tromethamine, 0.01 wt% methylparaben, and the balance water. The ratio of sodium colanate: carbomer: polyethylene glycol 400 is 1:0.1:0. The weight-average molecular weight of sodium colanate is 400 kDa. The preparation steps are as follows: Weigh sodium colanate, dissolve it in purified water, and place it in a steam sterilizer for pretreatment to remove endotoxins at 121°C for 30 minutes to obtain solution 1. Weigh carbomer, add it to a vacuum stirring tank, add purified water, heat at 80°C for 10 minutes, and mechanically stir until fully dissolved at a stirring speed of 300 rpm to obtain solution 2. Weigh polyethylene glycol 400 and methylparaben, add them to purified water, and mechanically stir at room temperature at a stirring speed of 300 rpm until fully dissolved to obtain solution 3. Solution 3 was poured into Solution 2 and mechanically stirred in a vacuum stirring tank. Solution 1 was then slowly added. Tromethamine was then added gradually to adjust the pH to 7. After vacuum degassing, a sodium colanate repair dressing was obtained. The sodium colanate repair dressing was packaged, sealed, and steam sterilized. Comparative Example 4 differs from Example 1 in that the polyethylene glycol 400 content was 0.0 wt%. The remaining components and preparation method were the same.

[0177] Comparative Example 5

[0178] This comparative example provides a sodium colanate repair dressing. It comprises 1.0 wt% sodium colanate, 0.1 wt% carbomer, 3.0 wt% polyethylene glycol 400, 0.3 wt% tromethamine, 0.01 wt% methylparaben, and the balance water. The ratio of sodium colanate: carbomer: polyethylene glycol 400 is 1:0.1:3. The weight-average molecular weight of sodium colanate is 4 kDa. The preparation steps are as follows: Weigh sodium colanate, dissolve it in purified water, and pre-treat it in a steam sterilizer to remove endotoxins at 121°C for 30 minutes to obtain Solution 1. Weigh carbomer, add it to a vacuum stirring tank, add purified water, heat at 80°C for 10 minutes, and mechanically stir until fully dissolved at 300 rpm to obtain Solution 2. Weigh polyethylene glycol 400 and methylparaben, add them to purified water, and mechanically stir them at room temperature at 300 rpm until fully dissolved to obtain Solution 3. Solution 3 was poured into Solution 2 and mechanically stirred in a vacuum stirring tank until uniform. Solution 1 was then slowly added. Tromethamine was then added gradually to adjust the pH to 7. After vacuum degassing, a sodium colanate repair dressing was obtained. The sodium colanate repair dressing was packaged, sealed, and steam sterilized. Comparative Example 5 differs from Example 1 in that the sodium colanate has a weight-average molecular weight of 4 kDa. The remaining components and preparation method were the same. Sodium colanate with a molecular weight of 4 kDa was obtained through repeated hydrolysis.

[0179] Comparative Example 6

[0180] This comparative example provides a repair dressing. It comprises 0.0 wt% sodium colanate, 0.1 wt% carbomer, 3.0 wt% polyethylene glycol 400, 0.3 wt% tromethamine, 0.01 wt% methylparaben, and the balance water. The ratio of sodium colanate: carbomer: polyethylene glycol 400 is 0:0.1:3. The weight-average molecular weight of sodium colanate is 400 kDa. The preparation steps are as follows: Weigh sodium colanate, dissolve it in purified water, and place it in a steam sterilizer for pretreatment to remove endotoxins at 121°C for 30 minutes to obtain solution 1. Weigh carbomer, add it to a vacuum stirring tank, add purified water, heat at 80°C for 10 minutes, and mechanically stir until fully dissolved at a stirring speed of 300 rpm to obtain solution 2. Weigh polyethylene glycol 400 and methylparaben, add them to purified water, and mechanically stir them at room temperature at a stirring speed of 300 rpm until fully dissolved to obtain solution 3. Solution 3 was poured into Solution 2 and mechanically stirred in a vacuum stirring tank. Solution 1 was then slowly added. Tromethamine was then added gradually to adjust the pH to 7. After vacuum degassing, a sodium colanate repair dressing was obtained. The sodium colanate repair dressing was packaged, sealed, and steam sterilized. Comparative Example 6 differs from Example 1 in that the sodium colanate content is 0.0 wt%. The remaining components and preparation method are the same.

[0181] Table 1 Summary of Examples and Comparative Examples

[0182]

[0183] In order to verify the effect of the composition ratio of the present invention on the performance, efficacy and biosafety, a comparative study and analysis was conducted on one or more samples in the above examples and comparative examples.

[0184] Test Example 1

[0185] The sodium colanate repair dressings prepared in Examples 1, 2, 3, and Comparative Example 3 were subjected to viscosity and macroscopic film-forming effect tests. The viscosity test method was based on the viscosity determination method in Part IV of the Chinese Pharmacopoeia (2020 edition). The macroscopic film-forming effect test was based on the literature "Performance Test of Recombinant Collagen Liquid Dressing for Class II Medical Devices [J]" by Wang Xiaochen et al.

[0186] The results (Table 2) show that carbomer, as a coagulant, has a certain impact on the viscosity and physical film formation of sodium colanate repair dressings. The lower the carbomer content, the lower the viscosity. When carbomer is absent, the viscosity is too low and film formation is difficult.

[0187] Table 2 Effect of carbomer on dressing viscosity and macroscopic film-forming effect

[0188] Example Name Carbomer / wt% Viscosity / mPas Macro film-forming effect Example 1 0.1 1501 Good film formation and thin thickness Example 2 0.3 2674 Good film formation and moderate thickness Example 3 0.5 4159 Good film formation and thick thickness Comparative Example 3 0.0 235 The viscosity is too low to form a film

[0189] Test Example 2

[0190] The sodium colanate repair dressings prepared in Examples 1, 4, and 5 and Comparative Example 4 were subjected to tests for solution uniformity and macroscopic film-forming effectiveness. Uniformity was assessed visually, while macroscopic film-forming effectiveness was assessed in the same manner as in Test Example 1. The results (Table 3) indicate that polyethylene glycol 400 (PEG) has a certain impact on the dispersion uniformity of the sodium colanate repair dressing during preparation. Lower PEG 400 content leads to poorer uniformity. Without PEG 400, the resulting solution exhibited poor uniformity, making it difficult to achieve a uniform dressing solution.

[0191] Table 3 Effect of polyethylene glycol 400 on the film-forming effect of dressing

[0192] Example Name Polyethylene glycol 400 / wt% Solution homogeneity Example 1 3.0 The solution is uniform and has no clumps Example 4 1.0 The solution is relatively uniform with very few flocs Example 5 5.0 The solution is uniform and has no clumps Comparative Example 4 0.0 Uneven, with many clumps

[0193] Test Example 3

[0194] The sodium colanate repair dressings prepared in Examples 1, 7, and 6, and the sodium hyaluronate dressing prepared in Comparative Example 1, were subjected to tests for macroscopic film-forming effect, physical film formation (such as water vapor transmission rate), and moisture retention and breathability (see Table 4). The macroscopic film-forming effect test method was the same as in Test Example 1. The water vapor transmission rate test was conducted in accordance with the method described in "YY / T 0471.2-2004 Test Methods for Contact Wound Dressings Part 2: Water Vapor Transmission Rate of Breathable Film Dressings." The results showed that as the sodium colanate content increased, the film-forming effect and uniformity gradually improved, the water vapor transmission rate gradually decreased, and the moisture retention effect increased. Compared to commonly used sodium hyaluronate dressings at the same sodium colanate content, the sodium colanate dressing had slightly better film-forming effect and water vapor transmission rate.

[0195] At the same time, 20 SD rats were selected and divided into 4 groups according to Table 4. Each group used the dressing samples of Examples 1, 7, 6, and Comparative Example 1, respectively, to simulate human light medical aesthetic laser treatment. First, a 4cm×4cm square laser treatment wound model was created on the center of the back of the experimental animal using a CO2 laser device (power of approximately 60W). The dressing was applied to each group for 30 minutes each time. The wound was observed daily after surgery. The experimental period was 2 weeks. The dressing was changed once a day in the first week and once every two days in the second week. The animal experiments were commissioned by Standex Science and Technology (Qingdao) Co., Ltd., and the experimental animals were sourced from Jinan Pengyue Experimental Animal Breeding Co., Ltd. A skin tester was used to test the skin moisture content and transepidermal water loss of the affected skin after surgery, as well as the moisturizing and wound healing effects of wound repair (see Table 5). The results showed that with the increase of sodium colanate content, the skin moisture content increased and the transepidermal water loss decreased after laser surgery, showing a good moisturizing effect. In addition, the wound healing rate also increased. It can be seen that the increase of sodium colanate helps to accelerate wound repair. At the same content, compared with the commonly used sodium hyaluronate dressings on the market, the skin moisture content, transepidermal water loss, and wound repair effects of sodium hyaluronate dressings are comparable.

[0196] Table 4 Effect of sodium colanate content on film-forming effect and water vapor transmission rate

[0197]

[0198] Table 5 Effect of sodium colanate content on skin water content, transepidermal water loss and wound repair in animals after laser treatment

[0199]

[0200] Test Example 4

[0201] The present invention tested the macroscopic film-forming properties of repair dressings prepared using sodium colanate of varying weight-average molecular weights in Examples 1, 6, and 5, as well as analyzed the raw material costs. The results (Table 6) indicate that molecular weight influences the film-forming properties of the dressings. Lower molecular weights result in poor film-forming properties and difficulty forming uniform films. However, molecular weights exceeding 8000 kDa may limit production capacity.

[0202] Table 6 Effect of molecular weight of sodium colanate on film-forming effect of dressing

[0203] Example Name Sodium colanate weight average molecular weight / kDa Macro film-forming effect Example 1 400 Good film formation and good uniformity Example 6 8000 Good film formation and uniformity, but limited production capacity Comparative Example 5 4 Poor film formation

[0204] Test Example 5

[0205] The present invention performs bacterial endotoxin and antibacterial detection on the sodium colanate repair dressing prepared in Example 1 and Comparative Example 2. In addition, the dressing is subjected to pyrogen, cytotoxicity, irritation, intradermal reaction, and acute toxicity-related biocompatibility tests according to the GB / T 16886 series of standards; bacterial endotoxin detection is performed with reference to the bacterial endotoxin test method of Part IV of the Chinese Pharmacopoeia (2020 edition); and antibacterial detection is performed with reference to the WS / T 650-2019 antibacterial and antibacterial effect evaluation method. The results show that the parameters of the steam treatment directly affect the bacterial endotoxin and pyrogen properties of the sodium colanate repair dressing. If the steam pretreatment meets the requirements, the bacterial endotoxin and pyrogen results of the dressing are qualified, meeting the requirements of medical device products (medical devices require that the bacterial endotoxin of the wound care device is not higher than 20EU / piece, and there should be no pyrogenic reaction); on the contrary, if the steam pretreatment is not in place, the bacterial endotoxin and pyrogen are unqualified. In addition, the results of antibacterial activity, cytotoxicity, irritation, intradermal reaction, and acute toxicity of both groups of samples were qualified, indicating that the sodium colanate repair dressing had good biocompatibility (Table 7).

[0206] Table 7 Effect of steam pretreatment on bacterial endotoxins and biocompatibility

[0207]

[0208] Test Example 6

[0209] Conduct human trial experiment of dressing. Select Example 1 for experiment, select 15 volunteers, use once every 2 days, and use continuously for 7 days. The use steps are: first clean the affected area and surrounding skin, unfold the dressing and apply it to the affected area, and apply it for 15-30 minutes. Observe the multi-dimensional evaluation of the initial experience of unpacking, during use, and after use. The results are shown in the attached figure. Figure 1 As shown in the figure, there was no adverse feedback during the entire use process, and the overall skin feel was good, which shows that the sodium colanate repair dressing has good applicability, good skin feel and moisturizing effect.

[0210] Incorporated by Reference

[0211] Each patent and scientific document mentioned herein is incorporated by reference in its entirety for all purposes.

[0212] Equivalence

[0213] The present invention may be embodied in other specific forms without departing from its spirit or essential characteristics. Therefore, the above embodiments should be considered in all cases as illustrative rather than limiting of the invention described herein. The scope of the present invention is therefore indicated by the appended claims rather than by the foregoing description, and all changes that come within the meaning and range of equivalence of the claims are intended to be embraced therein.

Claims

1. A composition comprising a colanate, a coagulant, a dispersant, water, and optionally a pH regulator and optionally a preservative, wherein: The coagulant is one or more selected from carbomer, kaolin and phospholipids; The dispersant is one or more selected from methanol, ethanol, n-propanol, isopropanol, ethyl acetate, n-hexane and polyethylene glycol; The content of the colanate is 1 wt% to 2 wt%; The content of the coagulant is 0.1 wt% to 0.5 wt%; The content of the dispersant is 1.0 wt% to 5.0 wt%; and The colanate salt is sodium colanate, and the weight average molecular weight of the sodium colanate is 400 kDa-8000 kDa.

2. The composition according to claim 1, wherein The pH regulator is one or more selected from citric acid, tartaric acid, citric acid, malic acid, chlorogenic acid, palmitic acid, glacial acetic acid, triethanolamine, sodium hydroxide, potassium hydroxide and tromethamine, and / or The preservative is one or more selected from sodium benzoate, potassium sorbate, sorbic acid and methylparaben.

3. The composition according to claim 1, wherein The composition consists of water, sodium colanate, carbomer, polyethylene glycol 400, tromethamine and methylparaben.

4. The composition according to any one of claims 1 to 3, wherein The content of the coagulant is 0.1 wt % to 0.3 wt %.

5. The composition according to any one of claims 1 to 3, wherein The content of the coagulant is 0.3 wt % to 0.5 wt %.

6. The composition according to any one of claims 1 to 3, wherein The content of the dispersant is 1.0 wt % to 3.0 wt %.

7. The composition according to any one of claims 1 to 3, wherein The content of the dispersant is 3.0 wt % to 5.0 wt %.

8. The composition according to any one of claims 1 to 3, wherein The content of the pH adjuster is 0.2 wt % to 0.3 wt %.

9. The composition according to any one of claims 1 to 3, wherein The content of the preservative is 0.01 wt % to 0.1 wt %.

10. The composition according to any one of claims 1 to 3, wherein The content of the preservative is 0.01 wt % to 0.02 wt %.

11. The composition according to any one of claims 1 to 3, wherein The content ratio of the colanate, the coagulant and the dispersant is 1-2:0.1-0.5:1-5.

12. A dressing comprising: a substrate and the composition according to any one of claims 1 to 11, wherein The base material serves as a carrier of the dressing.

13. The dressing according to claim 12, wherein The substrate is a hydrophilic fiber membrane.

14. The dressing according to claim 12, wherein The substrate is one or more of non-woven fabric, gauze, fruit fiber membrane, silk membrane, Tencel membrane, bacterial cellulose membrane, trehalose membrane, chitosan membrane, and Binchotan charcoal membrane.

15. A method for preparing the composition according to any one of claims 1 to 11 or the dressing according to any one of claims 12 to 14, comprising the following steps: (1) dissolving colanate in water and pretreating the solution to obtain solution A; (2) Fully dissolve the coagulant in water to obtain solution B; (3) mixing the dispersant and the optional preservative and fully dissolving them in water to obtain solution C; (4) Pour solution C into solution B and stir evenly to obtain solution D, and evenly disperse solution A in solution D; (5) optionally adding a pH adjuster to adjust the pH to 5 to 7; (6) Vacuum degassing; (7) Packaging, sealing, and steam sterilization; (8) Optionally, the resulting solution is loaded onto a support.

16. The method according to claim 15, wherein The pretreatment in step (1) is steam sterilization.

17. The method according to claim 16, wherein The temperature of the steam sterilization treatment in step (1) and / or step (7) is 100-130°C, and / or the time is 10-60 minutes.

18. Use of the composition according to any one of claims 1 to 11 or the dressing according to any one of claims 12 to 14 in preparing a product for aftercare of light medical aesthetics.

19. The use according to claim 18, wherein The light medical beauty includes one or more of laser, radio frequency, ultrasound, fruit acid peel, and water light injection treatment.

20. The use according to claim 18, wherein The light medical beauty includes one or more of Thermage and ultrasonic knife.

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