An antifouling developing coating material and its preparation method and application

Abstract

The present invention provides an antifouling developing coating material and a preparation method and application thereof. The antifouling developing coating material has a structure as shown in Formula I. In the structure of the antifouling developing coating material of the present invention, platinum nanoparticles are connected to modified phosphorylcholine polymers, the modified phosphorylcholine polymer part is used as an antifouling unit, and the platinum nanoparticles are used as a developing unit, so that the antifouling developing coating material has excellent antifouling performance and developing performance at the same time. In addition, the siloxane group in the antifouling unit can form a covalent bond with the surface of the substrate so that the coating is firmly bonded to the substrate, ensuring the bonding stability and safety of the antifouling developing coating material of the present invention on the substrate, and will not be lost or fall off over time, significantly improving the durability and reliability of the developing coating, and having a wide range of application prospects.

Description

[0001] This application claims priority to patent application number 202311820425.2. The filing date of the prior application is December 27, 2023. The name of the invention is a new anti-fouling developing coating material, its preparation method and application. Technical Field

[0002] The invention belongs to the technical field of medical materials and relates to an anti-fouling developing coating material and a preparation method and application thereof. Background Art

[0003] Medical developer coatings play a vital role in medical imaging. With the continuous advancement of medical imaging, the requirements for developer coatings are increasing. They are not only required to have excellent developer functions, but also to have excellent anti-fouling ability to resist bacterial protein adhesion to prevent bacterial infection and cross-infection, while keeping the surface clean and transparent to ensure clear and accurate images.

[0004] Medical antifouling developing coatings originated from the improvement of traditional developing coatings. Although traditional developing coatings provide developing functions, their antifouling performance is limited. With the increase in the use of medical devices, more urgent needs have driven scientists to study the addition of antifouling materials to improve antifouling performance. The antifouling principle mainly involves the hydrophilicity and lipophilicity of the material surface. The hydrophilic surface can make water form a large contact angle to prevent the retention of water and impurities, while the lipophilic surface can prevent the adhesion of organic matter or oil and reduce the adsorption of biological molecules. In recent years, the research on medical antifouling coatings has made significant progress. Researchers have developed excellent antifouling coatings by adjusting the surface properties. For example, the introduction of superhydrophobic polymer materials makes the surface present a superhydrophobic effect, achieving efficient self-cleaning and antifouling. At the same time, through the bionic design of special surface structures, such as micro-nano concave-convex and honeycomb, the surface contact area is reduced and the adhesion of pollutants is reduced. In addition, embedding bioactive molecules into the coating to form a "sterilization circle" can inhibit the reproduction of microorganisms, thereby improving the antifouling effect.

[0005] The developing performance of medical antifouling developer coatings has a crucial impact on the clarity of medical images and the accuracy of diagnosis. The developer coating needs to be sensitive to X-rays to ensure good development under X-ray irradiation. Development technology is widely used in medical imaging, and clear images are produced through the development of image-sensitive materials. Among them, X-ray development is a commonly used technology that relies on the absorption and scattering of X-rays. The developer coating plays a key role in this process, producing images by absorbing and scattering X-rays. The research on medical developer coatings has made continuous progress with the continuous advancement of medical imaging technology. Researchers have improved the development efficiency and image quality by improving the chemical composition of the developer and coating.

[0006] However, the interaction between the developer and the antifouling agent may reduce the development efficiency, so the effective combination of development and antifouling functions is still a challenging problem that needs to be solved. Summary of the invention

[0007] In view of the shortcomings of the prior art, the purpose of the present invention is to provide an anti-fouling developing coating material and a preparation method and application thereof. The anti-fouling developing coating material of the present invention realizes an effective combination of developing function and anti-fouling function.

[0008] In order to achieve the purpose of the invention, the present invention adopts the following technical solutions:

[0009] In one aspect, the present invention provides an anti-fouling developing coating material, wherein the anti-fouling developing coating material has a structure as shown in the following formula I:

[0010]

[0011] Wherein m=20, n=10, k=3, R is a siloxane-containing group, and L is a connecting functional group.

[0012] In the structure of the antifouling developing coating material of the present invention, platinum nanoparticles are connected to modified phosphorylcholine polymers, the modified phosphorylcholine polymer part is used as an antifouling unit, and the platinum nanoparticles are used as a developing unit, so that the antifouling developing coating material has excellent antifouling performance and developing performance at the same time. In addition, the siloxane group in the antifouling unit can form a covalent bond with the surface of the substrate so that the coating is firmly bonded to the substrate, ensuring the bonding stability and safety of the antifouling developing coating material of the present invention on the substrate, and will not be lost or fall off over time, significantly improving the durability and reliability of the developing coating, and having a wide range of application prospects.

[0013] In the present invention, m, n and k represent the number of structural units, wherein R in n structural units may be the same or different, and L in k structural units may be the same or different.

[0014] In some preferred embodiments, m:n=1:1-4:1, such as 1:1, 2:1, 3:1 or 4:1. In the present invention, the ratio of m:n is within 1:1-4:1.

[0015] In some preferred embodiments, R is selected from tris(trimethylsiloxy)silyl or trimethoxysilyl, the structure of which is as follows:

[0016]

[0017] In some preferred embodiments, L is selected from methylsilyl, vinylsilyl, aminosilyl, triphenylphosphine or -P(R)3, wherein R is an alkyl, olefin or mercapto group (i.e., a hydrocarbon phosphine ligand group or a mercaptophosphine ligand group).

[0018] In some preferred embodiments, the platinum nanoparticles are bound to L through electrical interaction.

[0019] In some preferred embodiments, the platinum nanoparticles are electrically interacted and bonded to the amino group, thiol group or phosphorus group in the L group.

[0020] In another aspect, the present invention provides a method for preparing the anti-fouling developing coating material as described above, the preparation method comprising the following steps:

[0021] (1) preparing a modified phosphorylcholine polymer modified with siloxane and a connecting functional group L;

[0022] (2) allowing the platinum nanoparticles to electrically interact and bind with the connecting functional group L in the modified phosphorylcholine polymer modified with siloxane and the connecting functional group L obtained in step (1) to obtain the anti-fouling developing coating material.

[0023] In some preferred embodiments, the preparation of the modified phosphorylcholine polymer modified with siloxane and the linking functional group L in step (1) comprises the following steps:

[0024] 2-Methacryloyloxyethyl phosphorylcholine reacts with a siloxane compound and a compound with an L group to obtain a modified phosphorylcholine polymer modified with the siloxane and the connecting functional group L.

[0025] In some preferred embodiments, the siloxane compound is methacryloxypropyltris(trimethylsiloxy)silane and / or 3-(methacryloxy)propyltrimethoxysilane.

[0026] In some preferred embodiments, the molar ratio of 2-methacryloyloxyethyl phosphorylcholine to the siloxane compound is 1:1-8:1, for example 1:1, 1.5:1, 2:1, 2.5:1, 3:1, 3.5:1, 4:1, 4.5:1, 5:1, 5.5:1, 6:1, 6.5:1, 7:1, 7.5:1 or 8:1.

[0027] In some preferred embodiments, the reaction of 2-methacryloyloxyethyl phosphorylcholine with the siloxane compound is carried out in the presence of 4-cyano-4-(thiobenzoyl)pentanoic acid.

[0028] In some preferred embodiments, the molar ratio of 2-methacryloyloxyethyl phosphorylcholine to 4-cyano-4-(thiobenzoyl)pentanoic acid is 1:1-5:1, for example, 1:1, 1.5:1, 2:1, 2.5:1, 3:1, 3.5:1, 4:1, 4.5:1 or 5:1.

[0029] In some preferred embodiments, the reaction of 2-methacryloyloxyethyl phosphorylcholine with the siloxane compound is carried out in the presence of azobisisobutyronitrile.

[0030] In some preferred embodiments, the molar ratio of 2-methacryloyloxyethyl phosphorylcholine to azobisisobutyronitrile is 1:1-5:1, for example, 1:1, 1.5:1, 2:1, 2.5:1, 3:1, 3.5:1, 4:1, 4.5:1 or 5:1.

[0031] In some preferred embodiments, the compound having an L group is a compound having an L group and a carbon-carbon unsaturated bond.

[0032] In some preferred embodiments, the compound carrying the L group is allyltriphenylphosphine bromide or propyltriphenylphosphine bromide.

[0033] In some preferred embodiments, the molar ratio of 2-methacryloyloxyethyl phosphorylcholine to the compound carrying an L group is 2:1-8:1, for example 2:1, 2.5:1, 3:1, 3.5:1, 4:1, 4.5:1, 5:1, 5.5:1, 6:1, 6.5:1, 7:1, 7.5:1 or 8:1.

[0034] Preferably, the reaction temperature in step (1) is 60°C-70°C (e.g., 60°C, 63°C, 65°C, 68°C or 70°C), and the reaction time is 16-64h (e.g., 16h, 18h, 20h, 24h, 28h, 30h, 36h, 40h, 42h, 48h, 50h, 55h, 58h, 60h or 64h).

[0035] Preferably, the solvent for the reaction in step (1) is n-propanol.

[0036] Preferably, the reaction in step (1) is carried out under nitrogen protection.

[0037] Preferably, the more specific operation of step (1) is: dissolving 2-methacryloyloxyethyl phosphorylcholine, 4-cyano-4-(thiobenzoyl)valeric acid, and azobisisobutyronitrile in n-propanol, slowly heating to 60-70° C. under nitrogen protection, stirring and reacting for 16-32 hours, then adding a siloxane compound and a compound with an L group, and continuing the reaction for 16-32 hours to obtain the modified phosphorylcholine polymer modified with siloxane and a connecting functional group L.

[0038] Preferably, after the reaction in step (1) is completed, a post-treatment step is further included, wherein the post-treatment step is to precipitate the obtained reaction solution in ether, filter and dry.

[0039] Preferably, the mass ratio of the modified phosphorylcholine polymer modified with siloxane and the connecting functional group L obtained in step (1) to the platinum nanoparticles in step (2) is 1-3:3-1, for example, 1:1, 1:1.5, 1:2, 1:2.5, 1:3, 1.5:1, 1.8:1, 2:1, 2.5:1 or 3:1.

[0040] Preferably, the combining in step (2) is completed under stirring at room temperature, and the stirring time is 6-12 h, such as 6 h, 7 h, 8 h, 9 h, 10 h, 11 h or 12 h.

[0041] In another aspect, the present invention provides the use of the antifouling developing coating material as described above in coating a substrate surface.

[0042] Preferably, the substrate surface includes a silicon-based surface, a glass-based surface, a metal-based surface, or a high-molecular polymer-based surface.

[0043] The material of the present invention can be applied to the surfaces of various substrates, including glass substrates, metal substrates and various plastic and high molecular polymer substrates (silicone rubber, polyethylene, polypropylene, polyvinyl chloride, polystyrene, polyurethane, etc.).

[0044] The anti-fouling developing coating material of the present invention has universal applicability. It can be covalently bonded to any silicon-based substrate by combining with the hydroxyl groups on the surface of the substrate through silicon-oxygen bonds, including various silicon-based surfaces such as glass, silicone sheets, and marble. It can be combined with other substrate surfaces through hydrophobic effects or van der Waals forces, and is widely applicable to different clinical and laboratory scenarios to meet the needs of different users.

[0045] In another aspect, the present invention provides an anti-fouling developing coating, wherein the raw materials for preparing the anti-fouling developing coating include the anti-fouling developing coating material as described above.

[0046] In another aspect, the present invention provides use of the antifouling developing coating material as described above in medical devices or medical materials, optical lenses or industrial printing.

[0047] Compared with the prior art, the present invention has the following beneficial effects:

[0048] First of all, the antifouling developing coating material of the present invention is successfully applied to medical devices to form an antifouling coating with excellent antifouling performance; compared with traditional developing coatings, it has achieved significant improvement in antifouling. The coating contains modified phosphorylcholine polymer as a unique antifouling agent component, which can effectively resist the attachment of bacterial proteins and prevent bacterial infection and cross infection. This property is crucial for medical safety, ensuring that medical equipment remains hygienic and safe during use. It can be applied to various medical scenarios, especially for equipment that requires high hygiene standards such as operating rooms and medical catheters. It is of special importance.

[0049] Secondly, platinum nanoparticles serve as developing units, which enable the anti-fouling developing coating material of the present invention to exhibit excellent developing effects. Compared with traditional developing coatings, its surface is in the form of an elastomeric coating that is insoluble in water and will not be lost into the human body's own metabolism, thereby ensuring the stability and durability of the developing effect, thereby eliminating the side effects that may be caused by the developing coating and improving the safety of the medical developing coating, which has positive significance for the patient's health and medical experience.

[0050] In addition, the anti-fouling developing coating material of the present invention has universal applicability. It can be covalently bonded to any silicon-based substrate, including glass, silicone sheets, marble and other silicon-based surfaces, by combining with silane bonds on the hydroxyl groups on the surface of the substrate. It can also be combined with other substrate surfaces through hydrophobic effects or van der Waals forces. It is widely applicable to different clinical and laboratory scenarios and meets the needs of different users. Its preparation method is simpler and less costly than traditional coatings, providing a feasible approach for large-scale application of developing coatings. BRIEF DESCRIPTION OF THE DRAWINGS

[0051] Figure 1 This is the H NMR spectrum (400 MHz, deuterated chloroform) of the antifouling developing coating material of Example 1;

[0052] Figure 2A This is a result diagram of the anti-protein adhesion test of the anti-fouling developing coating material of Example 1;

[0053] Figure 2B This is a result diagram of fluorescence quantitative analysis of the total amount of protein molecules adsorbed by the antifouling developing coating material of Example 1;

[0054] Figure 3A This is a result diagram of the anti-bacterial adhesion test of the anti-fouling developing coating material of Example 1;

[0055] Figure 3B This is a quantitative analysis result diagram of the bacterial colonies adsorbed by the anti-fouling developing coating material of Example 1;

[0056] Figure 4A This is a result diagram of the anti-platelet adhesion test of the anti-fouling developing coating material of Example 1;

[0057] Figure 4B This is a quantitative analysis result diagram of the number of platelets adhered to the anti-fouling developing coating material of Example 1;

[0058] Figure 5 : is an X-ray imaging development effect diagram of the antifouling development coating material of Example 1 on a polyurethane sheath; wherein AC is an X-ray imaging development effect diagram when the mass ratio of the antifouling functional polymer modified phosphorylcholine to the platinum nanoparticles of the coating is 2:1, 1:1, and 1:2, respectively, and D is an X-ray imaging development effect diagram of the blank control group;

[0059] Figure 6 This is a result diagram of quantitative analysis of the development intensity of the X-ray imaging development effect of the anti-fouling development coating material of Example 1 on the polyurethane sheath. DETAILED DESCRIPTION

[0060] The technical solution of the present invention is further described below by specific implementation methods. It should be understood by those skilled in the art that the embodiments are only to help understand the present invention and should not be regarded as specific limitations of the present invention.

[0061] Example 1

[0062] This embodiment provides an anti-fouling developing coating material, which is prepared by a method comprising the following steps.

[0063] 1) 0.75 mol of 2-methacryloyloxyethyl phosphorylcholine, 0.4 mol of 4-cyano-4-(thiobenzoyl)valeric acid, and 0.4 mol of azobisisobutyronitrile were dissolved in n-propanol, and the temperature was slowly raised to 65°C under nitrogen protection, and stirred for reaction for 24 hours. Then, a mixture of 0.125 mol of methacryloyloxypropyl tris(trimethylsiloxy)silane and 0.075 mol of allyltriphenylphosphine bromide was added, and the reaction was continued for 24 hours. The obtained n-propanol solution was added to ether for precipitation, and filtered and dried to obtain the obtained product. The reaction is shown below, and the obtained polymer NMR is as follows: Figure 1 As shown, a peak of methoxysilane was detected at 3.55 ppm.

[0064]

[0065] 2) The platinum nanoparticles are fully dispersed in a methanol / water binary solution, and then mixed with the antifouling functional polymer modified phosphorylcholine in a methanol / water binary solvent at a mass ratio of 1:2. The mixture is stirred at room temperature for 6 hours to allow the silyl groups of the antifouling molecule modified phosphorylcholine to be fully hydrolyzed and polymerized, thereby forming an antifouling developing polymer that can be coated on any silicon-based substrate, i.e., an antifouling developing coating material. The structure of the antifouling developing coating material is shown below:

[0066]

[0067] Wherein, m=20, n=10, k=3; platinum nanoparticles are combined with triphenylphosphine through electrical interaction.

[0068] Example 2

[0069] The anti-fouling developing coating material of Example 1 was used to test the anti-protein adhesion. In terms of anti-protein adsorption, the adsorption capacity of fibrin (FIB), serum protein (HB) and collagen (Col) on the anti-fouling developing coating was measured and characterized. The mass ratio of platinum nanoparticles to anti-fouling functional polymer modified phosphorylcholine in the anti-fouling developing coating used was 1:2, and the total concentration was 400 mg / mL. The protein molecules used were pre-modified with fluorescent molecules and adsorbed for 21 days. On the 3rd, 14th and 21st days (on the Figure 2A and Figure 2B The adsorption of various molecules on the coating was observed using a fluorescence microscope (Nikon Eclipse TE / Ti) at 4 pm (marked as day 3, day 7, and day 21 in the figure), and the control group was a blank control without antifouling developing coating. Figure 2A and Figure 2B (In the figure, uncoating means uncoated, and coating means coated, which have the same meaning as shown in the figure below).

[0070] like Figure 2A As shown in the figure, compared with the blank control, the coating exhibits excellent anti-protein adsorption ability. Serum protein is hardly adsorbed on the coating, and the amount of fibrin adsorbed on the anti-fouling developing coating is also very small, while the blank control group is full of protein molecules adsorbed on it. Furthermore, the total amount of adsorbed molecules was analyzed by fluorescence quantitative analysis, as shown in the figure below. Figure 2B As shown, compared with the blank control group, the total amount of protein adsorbed on the anti-fouling developing coating was significantly reduced, demonstrating the super strong anti-protein adsorption ability of the anti-fouling developing coating.

[0071] Example 3

[0072] The anti-fouling developing coating material of Example 1 was used to carry out a test on anti-bacterial adhesion. In terms of anti-bacterial adhesion, Candida albicans (C.albicans), Escherichia coli (E.coli), and Staphylococcus aureus (S.aureus) were used to characterize the anti-bacterial adsorption ability of the anti-fouling developing polymer coating. The mass ratio of platinum nanoparticles to anti-fouling functional polymer modified phosphorylcholine in the anti-fouling developing coating used was 1:2, and the total concentration was 400 mg / mL. After the samples were soaked in three kinds of high-concentration (108 / mL) bacterial solutions for 2 weeks, they were taken out and dried, and the number of bacteria on them was observed using SEM. The bacterial solution was a live bacterial solution, and the solvent was a dialysate. The live bacteria were replaced every three days to ensure bacterial activity. The control group was a blank control. The results are as follows Figure 3A and Figure 3B shown.

[0073] like Figure 3A As shown in the figure, under the adsorption of three different bacteria, after 2 weeks, there were obvious large colonies on the control group without antifouling developing coating, while there was no obvious colony growth on the sample coated with antifouling developing coating. Further, the adsorbed colonies were quantitatively analyzed, and the results were as follows: Figure 3B As shown, the samples using the antifouling developer coating significantly reduced bacterial adhesion, with the amount of bacterial adhesion reduced by 95% after 2 weeks.

[0074] Example 4

[0075] The anti-fouling developing coating material of Example 1 was used to conduct an anti-platelet adhesion test. The anti-fouling developing coating was coated on different substrate materials, such as NiTi, PVC, and TPU, respectively. The platelets were contacted with the test materials, and then washed and observed by SEM (S-3400N) to observe the effect of the anti-fouling developing coating on platelet adhesion. The control group was a blank negative control, and the mass ratios of the anti-fouling functional polymer modified phosphorylcholine and platinum nanoparticles in the experimental group were 2:1, 1:1, and 1:2, respectively. The results are shown in Figure 2. Figure 3A and Figure 3B As shown, Figure 4A As shown in Figure 2, the developed antifouling coating has a significant anti-platelet adhesion effect on all three materials. The number of adhered platelets was quantitatively analyzed, and the results are shown in Figure 2. Figure 4B As shown, it can be found that the anti-platelet adhesion effect is significantly enhanced with the increase of the proportion of antifouling functional polymer modified phosphorylcholine.

[0076] Example 5

[0077] The antifouling developing coating material of Example 1 was coated on a medical polyurethane sheath. The mass ratios of antifouling functional polymer modified phosphorylcholine and platinum nanoparticles in the experimental group were 2:1, 1:1, and 1:2, respectively, and the total concentration was 400 mg / mL. The control group was a blank negative control. Figure 5As shown in the figure, AC shows that three different mixing ratios of the developing antifouling coating on the polyurethane sheath have obvious developing effects, and D is the result of the control group. The developing intensity is analyzed, and the results are as follows Figure 6 As shown, it can be found that when the mass ratio is 2:1, 1:1, and 1:2, the development intensity is not much different, and is 3-4 times that of the control group.

[0078] From the above description, it can be seen that the antifouling and developing coating material of the present invention has excellent coating performance, antifouling performance and X-ray developing effect.

[0079] The modified phosphorylcholine polymer part in the antifouling developing coating material of the present invention serves as an antifouling unit, and the adsorbed platinum nanoparticles serve as developing units. The antifouling functional polymer modified phosphorylcholine and the platinum nanoparticles are combined through electrical interaction, and have excellent antifouling performance and developing performance. The siloxane group in the antifouling unit can form a covalent bond with the substrate surface so that the coating is firmly combined with the substrate, ensuring the binding stability and safety of the antifouling developing coating material of the present invention on the substrate. For example, the siloxane group can be covalently combined with the silicon-based substrate material, has excellent stability, will not be lost or fall off over time, and significantly improves the durability and reliability of the developing coating; the siloxane group can also be combined with other substrate surfaces through hydrophobic effects and van der Waals forces, thereby providing flexibility and applicability for the wide application of the developing coating. The antifouling developing coating material of the present invention can be coated on the surfaces of various substrates, including silicon-based substrates (such as glass substrates), metal substrates, and various plastic and high molecular polymer substrates (such as silicone rubber, polyethylene, polypropylene, polyvinyl chloride, polystyrene, polyurethane, etc.), and has wide applicability; the application fields are wide, for example, it can be used in the fields of medical devices, optical lenses and industrial printing. The coating gives the coated object the dual functions of antifouling and X-ray imaging, and exhibits excellent X-ray absorption performance during development, especially can provide accurate and clear development effects for medical imaging, and provide reliable imaging information for medical imaging.

[0080] The matters not described in detail in the present invention are all known technologies to those skilled in the art.

[0081] The applicant declares that the present invention illustrates the process method of the present invention through the above-mentioned embodiments, but the present invention is not limited to the above-mentioned process steps, that is, it does not mean that the present invention must rely on the above-mentioned process steps to be implemented. Those skilled in the art should understand that any improvement of the present invention, equivalent replacement of the raw materials selected by the present invention, addition of auxiliary components, selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.

Claims

1. An antifouling developing coating material, characterized in that: The antifouling developing coating material has a structure as shown in the following formula I: Formula I Wherein m=20, n=10, k=3, R is a siloxane-containing group, and L is a connecting functional group; The L is selected from methylsilyl, vinylsilyl, aminosilyl, triphenylphosphine or -P(R)3, wherein R is an alkyl, olefin or mercapto group; The platinum nanoparticles are combined with L through electrical interaction.

2. The antifouling developing coating material according to claim 1, characterized in that: R is selected from tris(trimethylsiloxy)silyl or trimethoxysilyl, and its structure is as follows: 、 。 3. The antifouling developing coating material according to claim 1, characterized in that: The platinum nanoparticles are electrically interacted and combined with the amino group, the thiol group or the phosphorus group in the L group.

4. A method for preparing an antifouling developing coating material according to any one of claims 1 to 3, characterized in that: The preparation method comprises the following steps: (1) preparing a modified phosphorylcholine polymer modified with siloxane and a connecting functional group L; (2) The platinum nanoparticles are electrically interacted and combined with the connecting functional group L in the modified phosphorylcholine polymer modified with siloxane and the connecting functional group L obtained in step (1) to obtain the anti-fouling developing coating material.

5. The preparation method according to claim 4, characterized in that: The preparation of the modified phosphorylcholine polymer modified with siloxane and the connecting functional group L in step (1) comprises the following steps: 2-Methacryloyloxyethyl phosphorylcholine reacts with a siloxane compound and a compound with an L group to obtain a modified phosphorylcholine polymer modified with the siloxane and the connecting functional group L.

6. The preparation method according to claim 5, characterized in that: The siloxane compound is methacryloxypropyltris(trimethylsiloxy)silane and / or 3-(methacryloxy)propyltrimethoxysilane.

7. The preparation method according to claim 5, characterized in that: The molar ratio of the 2-methacryloyloxyethyl phosphorylcholine to the siloxane compound is 1:1-8:

1.

8. The preparation method according to claim 5, characterized in that: The reaction of 2-methacryloyloxyethyl phosphorylcholine with the siloxane compound is carried out in the presence of 4-cyano-4-(thiobenzoyl)valeric acid.

9. The preparation method according to claim 8, characterized in that: The molar ratio of the 2-methacryloyloxyethyl phosphorylcholine to 4-cyano-4-(thiobenzoyl)pentanoic acid is 1:1-5:

1.

10. The preparation method according to claim 5, characterized in that: The reaction of 2-methacryloyloxyethyl phosphorylcholine with the siloxane compound is carried out in the presence of azobisisobutyronitrile.

11. The preparation method according to claim 10, characterized in that: The molar ratio of the 2-methacryloyloxyethyl phosphorylcholine to azobisisobutyronitrile is 1:1-5:

1.

12. The preparation method according to claim 5, characterized in that: The compound having an L group is a compound having an L group and a carbon-carbon unsaturated bond.

13. The preparation method according to claim 12, characterized in that: The compound with L group is allyl triphenyl phosphonium bromide or propyl triphenyl phosphonium bromide.

14. The preparation method according to claim 5, characterized in that: The molar ratio of the 2-methacryloyloxyethyl phosphorylcholine to the compound with an L group is 2:1-8:

1.

15. The preparation method according to claim 4, characterized in that: The reaction temperature in step (1) is 60°C-70°C, and the reaction time is 16-64h.

16. The preparation method according to claim 4, characterized in that: The solvent for the reaction in step (1) is n-propanol.

17. The preparation method according to claim 4, characterized in that: The reaction in step (1) is carried out under nitrogen protection.

18. The preparation method according to claim 4, characterized in that: A more specific operation of step (1) is as follows: 2-methacryloyloxyethyl phosphorylcholine, 4-cyano-4-(thiobenzoyl)valeric acid, and azobisisobutyronitrile are dissolved in n-propanol, and the temperature is slowly raised to 60-70° C. under nitrogen protection, and the reaction is stirred for 16-32 hours, and then a siloxane compound and a compound with an L group are added, and the reaction is continued for 16-32 hours to obtain the modified phosphorylcholine polymer modified with siloxane and a connecting functional group L.

19. The preparation method according to claim 4, characterized in that: After the reaction in step (1) is completed, a post-treatment step is further included, wherein the post-treatment step is to precipitate the obtained reaction solution in ether, filter and dry.

20. The preparation method according to claim 4, characterized in that: The mass ratio of the modified phosphorylcholine polymer modified with siloxane and the connecting functional group L obtained in step (1) to the platinum nanoparticles in step (2) is 1-3:3-1.

21. The preparation method according to claim 4, characterized in that: The combination in step (2) is completed under stirring at room temperature, and the stirring time is 6-12 hours.

22. Use of the antifouling developing coating material according to any one of claims 1 to 3 in coating a substrate surface.

23. The use according to claim 22, characterized in that The substrate surface includes a silicon-based surface, a glass-based surface, a metal-based surface, and a high-molecular polymer-based surface.

24. An antifouling developing coating, characterized in that: The raw material for preparing the anti-fouling developing coating comprises the anti-fouling developing coating material according to any one of claims 1 to 3.

25. Use of the antifouling developing coating material according to any one of claims 1 to 3 in medical devices or medical materials, optical lenses or industrial printing.

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