Drug pretreatment device for osimertinib preparation

Abstract

The invention relates to the technical field of drug pretreatment, and discloses a drug pretreatment device for osimertinib preparation, which comprises a treatment box and a drying mechanism, a supporting plate is arranged in the treatment box; the drying mechanism comprises a drying tank, an inner tank piece, a driving motor, a heating box, warm air equipment and an air guide pipe; the drying mechanism further comprises an exhaust pipe and a control valve; the osimertinib raw materials can be dried through cooperation of the arranged treatment box, the arranged drying mechanism, the arranged heating box, the arranged warm air equipment and the arranged air guide pipe, and the osimertinib raw materials in the inner tank piece can make full contact with hot air through the arranged driving motor, the arranged first transmission wheel, the arranged second transmission wheel and the arranged transmission belt; and by arranging a reinforcing beam, a reinforcing plate, a damping spring and a connector, the stability of connection between the drying tank and the treatment box can be improved.

Description

Technical Field

[0001] The present invention relates to the technical field of drug pretreatment, and in particular to a drug pretreatment device for preparing osimertinib. Background Art

[0002] Osimertinib is an oral small molecule tyrosine kinase inhibitor, mainly used to treat non-small cell lung cancer. Osimertinib inhibits the activity of EGFR mutations (such as T790M mutation), thereby inhibiting the growth and spread of cancer cells. Osimertinib has significant therapeutic efficacy and can significantly prolong patients' survival and improve their quality of life.

[0003] Drug pretreatment is an important link in the production process of drug preparations, which mainly includes the steps of drug extraction, separation, purification, concentration, drying, etc. When preparing osimertinib, the raw materials need to be dried. Therefore, a drug pretreatment device for the preparation of osimertinib is needed.

[0004] The existing drug pretreatment device for preparing osimertinib has certain disadvantages when in use. When in use, the existing drug pretreatment device for preparing osimertinib usually directly performs hot air drying on the osimertinib raw material, and a large amount of osimertinib raw material is easily piled up during drying, thereby reducing the drying efficiency of the osimertinib raw material and failing to meet people's needs.

[0005] Therefore, a drug pretreatment device for preparing osimertinib is proposed. Summary of the invention

[0006] 1. Technical issues to be resolved In view of the deficiencies in the prior art, the present invention provides a drug pretreatment device for preparing osimertinib, which can solve the technical problems in the background technology.

[0007] (II) Technical solution The present invention is implemented by the following technical scheme: a drug pretreatment device for preparing osimertinib, comprising a treatment box and a drying mechanism arranged on the treatment box; wherein a controller is arranged on an upper part of one side surface of the treatment box, and an alarm is arranged on the controller; a support plate is arranged inside the treatment box; the drying mechanism comprises a drying tank detachably mounted on the upper end of the support plate, an inner tank part rotatably arranged inside the drying tank, and a driving motor detachably mounted on the upper end of the drying tank and controlling the inner tank part to rotate; the drying mechanism also comprises a heating box detachably mounted on the lower inner side of the treatment box, a warm air device connected to the heating box, and an air duct connecting the heating box with the inner tank part, wherein the heating box and the warm air device cooperate to dry the raw material of osimertinib inside the inner tank part; the drying mechanism also comprises an exhaust pipe detachably mounted on the inner tank part and a control valve arranged on the exhaust pipe.

[0008] Preferably, a fixing frame is detachably mounted on the outer wall of the drying tank, a first transmission wheel is rotatably mounted on the fixing frame, a second transmission wheel is detachably mounted on the output shaft of the driving motor, a transmission belt connected to the second transmission wheel is mounted on the first transmission wheel, and the driving motor, the first transmission wheel, the second transmission wheel and the transmission belt cooperate to control the rotation of the inner tank.

[0009] Preferably, a mounting frame is provided at the upper end of the drying tank, and a mounting rod fixed to the mounting frame is provided on the driving motor.

[0010] Preferably, reinforcing beams are symmetrically arranged on the inner upper part of the processing box, reinforcing plates are symmetrically arranged on the drying tank, shock-absorbing springs are detachably mounted on the reinforcing plates, connectors connected to the shock-absorbing springs are arranged on the reinforcing beams, and the combination of the shock-absorbing springs and the connector can improve the stability of the drying tank.

[0011] Preferably, the connector includes a first connecting member and two groups of second connecting members threadedly mounted at both ends of the first connecting member, and the two groups of the second connecting members are respectively connected to the reinforcement beam and the shock-absorbing spring.

[0012] Preferably, the drying tank comprises an outer tank body and an outer tank cover detachably fixed to the outer tank body, the outer tank cover is provided with a through groove matching the inner tank part, and the outer tank cover is provided with a plurality of groups of bolts connected to the outer tank body.

[0013] Preferably, one end of the inner tank part is in a funnel structure and extends out of the through slot, an inner tank cover is provided at one end of the inner tank part, the exhaust pipe and the air guide pipe are both detachably fixed to the inner tank cover, an auxiliary part connected to the outer wall of the outer tank body is provided on the outer wall of the inner tank part, and the other end of the inner tank part extends out of the outer tank body and is detachably connected to the rotating shaft of the first transmission wheel.

[0014] Preferably, the inner tank is provided with a discharge piece connected with the outer tank, the outer tank is provided with a discharge port matching the discharge piece, and the interior of the processing box is provided with a collection box corresponding to the discharge port.

[0015] Preferably, the exhaust pipe is configured as a bent hose structure, the processing box is provided with a closable box door, and one end of the exhaust pipe and the air guide pipe both penetrate the box door and extend into the interior of the processing box.

[0016] Preferably, the bottom end of the processing box is provided with a plurality of sets of universal wheels and support feet provided on one side of the universal wheels. (III) Beneficial Effects Compared with the prior art, the present invention provides a drug pretreatment device for preparing osimertinib, which has the following beneficial effects: The drug pretreatment device for preparing osimertinib can dry osimertinib raw materials by means of a processing box and a drying mechanism, a heating box, a warm air device and an air duct. The osimertinib raw materials in the inner tank can be fully contacted with hot air by means of a driving motor, a first transmission wheel, a second transmission wheel and a transmission belt, thereby improving the drying efficiency of the osimertinib raw materials. The reinforcement beam, the reinforcement plate, the shock-absorbing spring and the connector can improve the stability of the connection between the drying tank and the processing box. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is the overall structure diagram of the present invention.

[0018] Figure 2 It is a partial structural diagram of the processing box and the drying mechanism in the present invention.

[0019] Figure 3 It is a partial structural diagram of the drying tank and the driving motor in the present invention.

[0020] Figure 4 It is a partial structural diagram of the drying tank and the inner tank parts in the present invention.

[0021] Figure 5 It is a partial structural diagram of the inner tank and the driving motor in the present invention.

[0022] Figure 6 It is a partial structural diagram of the connector and the shock absorbing spring in the present invention. In the figure: 1. treatment box; 2. controller; 3. alarm; 4. support plate; 5. drying tank; 6. inner tank parts; 7. drive motor; 8. heating box; 9. warm air equipment; 10. air guide duct; 11. exhaust pipe; 12. control valve; 13. fixing frame; 14. first transmission wheel; 15. second transmission wheel; 16. transmission belt; 17. mounting frame; 18. mounting rod; 19. reinforcement beam; 20. reinforcement plate; 21. shock-absorbing spring; 22. connector; 23. first connecting piece; 24. second connecting piece; 25. outer tank body; 26. outer tank cover; 27. inner tank cover; 28. discharge port; 29. ​​collection box; 30. box door; 31. universal wheel; 32. support foot. DETAILED DESCRIPTION

[0023] The present invention is further described below in conjunction with the accompanying drawings and specific implementation methods. It should be noted that, under the premise of no conflict, the various embodiments or technical features described below can be arbitrarily combined to form a new embodiment.

[0024] Example 1: Please refer to Figure 1-6, a drug pretreatment device for preparing osimertinib in this embodiment comprises a treatment box 1 and a drying mechanism arranged on the treatment box 1; wherein a controller 2 is arranged on the upper part of one side surface of the treatment box 1, and an alarm 3 is arranged on the controller 2; a support plate 4 is arranged inside the treatment box 1; the drying mechanism comprises a drying tank 5 detachably mounted on the upper end of the support plate 4, an inner tank part 6 rotatably arranged inside the drying tank 5, and a driving motor 7 detachably mounted on the upper end of the drying tank 5 and controlling the inner tank part 6 to rotate; the drying mechanism also comprises a heating box 8 detachably mounted on the lower inner side of the treatment box 1, a warm air device 9 connected to the heating box 8, and a heating device 9 connecting the heating box 8 to the inner tank 6. The air duct 10 connected to the tank 6, the heating box 8 and the warm air device 9 cooperate to dry the osimertinib raw material inside the inner tank 6; the drying mechanism also includes an exhaust pipe 11 detachably mounted on the inner tank 6 and a control valve 12 arranged on the exhaust pipe 11. The osimertinib raw material is placed in the inner tank 6, the warm air device 9 and the heating box 8 are started, the warm air is introduced into the heating box 8 for heating, and is introduced into the interior of the inner tank 6 through the air duct 10 to dry the osimertinib raw material, the drive motor 7 is started, and the inner tank 6 is driven to rotate, so that the osimertinib raw material is fully in contact with the hot air, thereby improving the drying efficiency of the osimertinib raw material.

[0025] A fixing frame 13 is detachably mounted on the outer wall of the drying tank 5, a first transmission wheel 14 is rotatably mounted on the fixing frame 13, a second transmission wheel 15 is detachably mounted on the output shaft of the driving motor 7, a transmission belt 16 connected to the second transmission wheel 15 is mounted on the first transmission wheel 14, the driving motor 7, the first transmission wheel 14, the second transmission wheel 15 and the transmission belt 16 cooperate to control the inner tank part 6 to rotate, start the driving motor 7, drive the second transmission wheel 15 to rotate, the second transmission wheel 15 drives the transmission belt 16 to rotate, the transmission belt 16 drives the first transmission wheel 14 to rotate, and the first transmission wheel 14 drives the inner tank part 6 to rotate.

[0026] A mounting frame 17 is disposed at the upper end of the drying tank 5 , and a mounting rod 18 fixed to the mounting frame 17 is disposed on the driving motor 7 .

[0027] A reinforcing beam 19 is symmetrically arranged on the inner upper part of the processing box 1, and a reinforcing plate 20 is symmetrically arranged on the drying tank 5. A shock-absorbing spring 21 is detachably installed on the reinforcing plate 20. A connector 22 connected to the shock-absorbing spring 21 is arranged on the reinforcing beam 19. The cooperation between the shock-absorbing spring 21 and the connector 22 can improve the stability of the drying tank 5.

[0028] The connector 22 includes a first connecting member 23 and two groups of second connecting members 24 threadedly mounted at two ends of the first connecting member 23 . The two groups of second connecting members 24 are respectively connected to the reinforcing beam 19 and the shock absorbing spring 21 .

[0029] The drying tank 5 includes an outer tank body 25 and an outer tank cover 26 detachably fixed to the outer tank body 25 . The outer tank cover 26 is provided with a through groove matching the inner tank part 6 . The outer tank cover 26 is provided with a plurality of bolts connected to the outer tank body 25 .

[0030] One end of the inner tank part 6 is in a funnel structure and extends out of the through groove. An inner tank cover 27 is provided at one end of the inner tank part 6. The exhaust pipe 11 and the air guide pipe 10 are both detachably fixed to the inner tank cover 27. The outer wall of the inner tank part 6 is provided with an auxiliary part connected to the outer wall of the outer tank body 25. The other end of the inner tank part 6 extends out of the outer tank body 25 and is detachably connected to the rotating shaft of the first transmission wheel 14.

[0031] The inner tank 6 is provided with a discharge piece connected with the outer tank body 25 , the outer tank body 25 is provided with a discharge port 28 matching the discharge piece, and a collection box 29 corresponding to the discharge port 28 is provided inside the processing box 1 .

[0032] The exhaust pipe 11 is configured as a bent hose structure. A closable box door 30 is provided on the processing box 1 . One end of the exhaust pipe 11 and the air guide pipe 10 both penetrate the box door 30 and extend into the interior of the processing box 1 .

[0033] The bottom end of the processing box 1 is provided with a plurality of sets of universal wheels 31 and supporting feet 32 ​​arranged on one side of the universal wheels 31 . The drug pretreatment device for preparing osimertinib, wherein the raw material of osimertinib is placed in an inner tank 6, a warm air device 9 and a heating box 8 are started, and the warm air is introduced into the heating box 8 for heating, and is introduced into the interior of the inner tank 6 through an air duct 10 to dry the raw material of osimertinib, and a driving motor 7 is started to drive the inner tank 6 to rotate, so that the raw material of osimertinib is fully in contact with the hot air, thereby improving the drying efficiency of the raw material of osimertinib; The driving motor 7 is started to drive the second transmission wheel 15 to rotate, the second transmission wheel 15 drives the transmission belt 16 to rotate, the transmission belt 16 drives the first transmission wheel 14 to rotate, and the first transmission wheel 14 drives the inner tank 6 to rotate. The drug pretreatment device for preparing osimertinib can dry the osimertinib raw material by means of the processing box 1 and the drying mechanism, the heating box 8, the warm air device 9 and the air duct 10. The driving motor 7, the first transmission wheel 14, the second transmission wheel 15 and the transmission belt 16 can make the osimertinib raw material in the inner tank 6 fully contact with the hot air, thereby improving the drying efficiency of the osimertinib raw material. The reinforcing beam 19, the reinforcing plate 20, the shock-absorbing spring 21 and the connector 22 can improve the stability of the connection between the drying tank 5 and the processing box 1.

[0034] The above-mentioned embodiments are only preferred embodiments of the present invention and cannot be used to limit the scope of protection of the present invention. Any non-substantial changes and substitutions made by technicians in this field on the basis of the present invention shall fall within the scope of protection required by the present invention.

Claims

1. A drug pretreatment device for preparing osimertinib, characterized in that: include: A processing box (1) and a drying mechanism arranged on the processing box (1); Wherein, a controller (2) is provided on an upper portion of a side surface of the processing box (1), and an alarm (3) is provided on the controller (2); A support plate (4) is provided inside the processing box (1); The drying mechanism comprises a drying tank (5) detachably mounted on the upper end of the support plate (4), an inner tank component (6) rotatably arranged inside the drying tank (5), and a driving motor (7) detachably mounted on the upper end of the drying tank (5) and controlling the inner tank component (6) to rotate; The drying mechanism further comprises a heating box (8) detachably mounted on the lower inner portion of the processing box (1), a warm air device (9) connected to the heating box (8), and an air guide pipe (10) connecting the heating box (8) and the inner tank (6); The drying mechanism further comprises an exhaust pipe (11) detachably mounted on the inner tank (6) and a control valve (12) arranged on the exhaust pipe (11).

2. A drug pretreatment device for preparing osimertinib according to claim 1, characterized in that: A fixing frame (13) is detachably mounted on the outer wall of the drying tank (5); a first transmission wheel (14) is rotatably mounted on the fixing frame (13); a second transmission wheel (15) is detachably mounted on the output shaft of the driving motor (7); and a transmission belt (16) connected to the second transmission wheel (15) is mounted on the first transmission wheel (14).

3. A drug pretreatment device for preparing osimertinib according to claim 2, characterized in that: A mounting frame (17) is provided at the upper end of the drying tank (5), and a mounting rod (18) fixed to the mounting frame (17) is provided on the driving motor (7).

4. The drug pretreatment device for preparing osimertinib according to claim 3, characterized in that: A reinforcing beam (19) is symmetrically arranged on the inner upper part of the processing box (1), a reinforcing plate (20) is symmetrically arranged on the drying tank (5), a shock absorbing spring (21) is detachably mounted on the reinforcing plate (20), and a connector (22) connected to the shock absorbing spring (21) is arranged on the reinforcing beam (19).

5. The drug pretreatment device for preparing osimertinib according to claim 4, characterized in that: The connector (22) comprises a first connecting member (23) and two groups of second connecting members (24) threadedly mounted at both ends of the first connecting member (23), the two groups of the second connecting members (24) being respectively connected to the reinforcing beam (19) and the shock absorbing spring (21).

6. The drug pretreatment device for preparing osimertinib according to claim 5, characterized in that: The drying tank (5) comprises an outer tank body (25) and an outer tank cover (26) detachably fixed to the outer tank body (25); the outer tank cover (26) is provided with a through groove matching the inner tank member (6); and the outer tank cover (26) is provided with a plurality of groups of bolts connected to the outer tank body (25).

7. The drug pretreatment device for preparing osimertinib according to claim 6, characterized in that: One end of the inner tank member (6) is in a funnel structure and extends out of the through slot; an inner tank cover (27) is provided at one end of the inner tank member (6); the exhaust pipe (11) and the air guide pipe (10) are both detachably fixed to the inner tank cover (27); an auxiliary member connected to the outer wall of the outer tank body (25) is provided on the outer wall of the inner tank member (6); and the other end of the inner tank member (6) extends out of the outer tank body (25) and is detachably connected to the rotating shaft of the first transmission wheel (14).

8. The drug pretreatment device for preparing osimertinib according to claim 7, characterized in that: The inner tank (6) is provided with a discharge piece connected to the outer tank body (25); the outer tank body (25) is provided with a discharge port (28) matching the discharge piece; and the interior of the processing box (1) is provided with a collection box (29) corresponding to the discharge port (28).

9. The drug pretreatment device for preparing osimertinib according to claim 8, characterized in that: The exhaust pipe (11) is configured as a bent hose structure, the processing box (1) is provided with a closable box door (30), and one end of the exhaust pipe (11) and the air guide pipe (10) both penetrate the box door (30) and extend into the interior of the processing box (1).

10. The drug pretreatment device for preparing osimertinib according to claim 9, characterized in that: The bottom end of the processing box (1) is provided with a plurality of sets of universal wheels (31) and supporting feet (32) arranged on one side of the universal wheels (31).

Images