Toothpaste for resisting dentin sensitivity and preparation method thereof, and method for resisting dentin sensitivity

Abstract

The present application relates to the field of oral care, and to a toothpaste for resisting dentin sensitivity, a preparation method thereof, and a method for resisting dentin sensitivity. The toothpaste for resisting dentin sensitivity comprises: an extrusion container, a first paste, and a second paste; the extrusion container comprises: a container body; at least two sub-chambers are included along the extension direction of the container body, and the first paste and the second paste are each contained in a sub-chamber; the first paste comprises: bioactive glass; the second paste comprises water. When in use, the first paste and the second paste are contacted and mixed, and the water quickly activates the release of the activity of the bioactive glass. The activated bioactive glass can target mineralization and block the exposed dentin, thereby fundamentally improving the problem of dentin sensitivity.

Description

Technical Field

[0001] The present application relates to the field of oral care, and in particular, to a toothpaste for resisting dentin sensitivity, a preparation method thereof, and a method for resisting dentin sensitivity. Background Art

[0002] According to the second national epidemiological survey on adult dentin hypersensitivity and tooth erosion in 2021, the prevalence of dentin hypersensitivity reached 36.7%. In other words, one in every three people is troubled by tooth sensitivity and toothache, and the average number of sensitive teeth in my country is 1.5. Once tooth sensitivity occurs, the symptoms usually last longer. The chronic pain caused by tooth sensitivity will subtly reduce our quality of life.

[0003] The tissue structure of human teeth from the outside to the inside consists of four parts: enamel, dentin, cementum and pulp. Enamel is a translucent calcified tissue that covers the crown surface of the tooth. It is milky white or light yellow and is composed of countless dense enamel columns and a small amount of columnar interstitial. The thickness of enamel in different parts varies. It can reach 2.5mm at the tip of the tooth, gradually thinning towards the jaw, and the thinnest at the neck of the tooth, about 2mm. The outermost layer of each of our teeth is wrapped in highly mineralized enamel, which is the hardest tissue in the human body and also the "tooth barrier". Although enamel is hard, it is not indestructible. It is afraid of grinding, acid and brittleness. Habits such as brushing incorrectly, grinding teeth at night, eating hard foods, and drinking acidic beverages will cause the enamel to be worn thinner and thinner until the dentin is exposed in the mouth. When the dentin is exposed to the mouth, tooth sensitivity problems arise. Dentin is the main part of the tooth. It is a highly mineralized special tissue that occupies the main part of the tooth tissue and constitutes the outer wall of the pulp cavity. The crown dentin is covered with enamel, and the root is covered with cementum. Dentin is composed of matrix and dentinal tubules. There are cell processes from odontoblasts in the dentinal tubules, which are used for nutrient metabolism. The degree of calcification and hardness of dentin are slightly lower than that of enamel. It is light yellow and opaque. Inorganic salts account for about 70%, mainly hydroxyapatite, calcium phosphate, etc.; organic matter accounts for about 30%, mainly collagen. The liquid flowing in the dentinal tubules can transmit signals from the outside to the inner pulp nerves. Ice, heat, sweetness, acid, mechanical stimulation and other influencing factors will change the flow of liquid in the dentinal tubules. These small movements will quickly transmit to the pulp, activate the pulp nerve fibers, and cause a short and sharp pain. When the dentin is exposed, the dentinal tubules are particularly susceptible to stimulation, and toothache occurs more frequently.

[0004] Dentin hypersensitivity clinically refers to the sourness, tenderness, pain and other symptoms caused by external stimuli such as temperature (cold, hot), chemical substances (acid, sweet) and mechanical effects (friction or biting hard objects). Dentin hypersensitivity is a common oral disease with a high incidence rate in adults. It is the main cause of toothache clinically.

[0005] There are three main theories about the mechanism of dentin hypersensitivity: ① Nerve theory: It is believed that there are pulp nerve endings in the dentin, and the sensation is transmitted from the surface of the dentin to the pulp, causing stimulation; ② Dentin fiber conduction theory: It is believed that the protoplasmic processes that constitute the dentin cells contain acetylcholinesterase, which can cause nerve conduction and produce pain after being stimulated; ③ Fluid dynamics theory: It is believed that external stimuli promote the flow of fluid in the dentinal tubules, and the flowing fluid stimulates the peripheral nerves located at the pulp and dentin junction, resulting in characteristic clinical symptoms. The fluid dynamics theory is the most widely accepted theory of the mechanism of dentin sensitivity. According to this theory, there are two effective treatments for dentin hypersensitivity symptoms: one is to calm the pulp nerves, reduce the sensitivity of the dentin and pulp nerve endings, thereby relieving the soreness symptoms caused by dentin hypersensitivity (treating the symptoms); the other is to block the dentinal tubules, reduce the permeability of the dentin, and reduce or avoid the flow of fluid in the dentin (treating the root cause).

[0006] The existing anti-dentin hypersensitivity toothpaste or oral desensitizing paste on the market mainly contains desensitizing agents such as strontium chloride, potassium nitrate, fluoride, and hydroxyapatite. However, these anti-sensitivity toothpastes can only treat the symptoms but not the root cause. Summary of the invention

[0007] The purpose of the embodiments of the present application is to provide a toothpaste for resisting dentin sensitivity and a preparation method thereof, and a method for resisting dentin sensitivity.

[0008] In a first aspect, the present application provides a toothpaste for resisting dentin sensitivity, comprising:

[0009] Extruding a container, a first paste, and a second paste;

[0010] The extrusion container comprises: a container body;

[0011] The container body comprises at least two sub-chambers along the extension direction thereof, and the first paste and the second paste are respectively contained in one sub-chamber;

[0012] The first paste comprises: bioactive glass and a first carrier acceptable to toothpaste, and the first paste does not contain water; the second paste comprises: water and a second carrier acceptable to toothpaste.

[0013] The above technical scheme of the present application provides a new toothpaste against dentin sensitivity that is "mixable and ready to use", wherein the first paste includes: bioactive glass; the second paste includes water; during the use stage, the first paste and the second paste are squeezed out from the toothpaste outlet; the first paste and the second paste are not pre-mixed, but are mixed by brushing when acting on the oral cavity. At this time, the water in the second paste becomes an effective ingredient, and as an important promoter of bioactive glass, it can quickly activate the release of the activity of bioactive glass and enhance the activity of bioactive glass. The activated bioactive glass can target mineralization and block exposed dentin, thereby fundamentally improving the problem of dentin sensitivity.

[0014] However, it is generally believed in the art that water is not good for bioactive glass, so the common bioactive glass anti-sensitivity toothpaste on the market usually adopts an anhydrous formula, but this anhydrous formula has problems such as poor taste, poor foaming (if the bioactive glass is compounded with anionic foaming agents to improve the foaming effect, the activity of the bioactive agent will be significantly reduced), and poor decontamination. The present application creatively discovered that water can be used as a promoter for bioactive glass, and through the above-mentioned chamber setting and "mix and use" method, water is used as an important promoter for bioactive glass, and the problems of anhydrous formula are avoided.

[0015] That is, the above technical scheme of the present application creatively proposes a "mix-and-use" anti-dentin sensitivity toothpaste, which effectively ensures the activity of the bioactive glass in the toothpaste, so that it interacts with each other during use and releases its activity, thereby achieving truly effective anti-dentin sensitivity; and overcomes the technical prejudice in this field (water is not good for bioactive glass).

[0016] In other embodiments of the present application, the amount of bioactive glass added to the first paste is 1% to 10% by mass.

[0017] In other embodiments of the present application, the amount of water added to the second paste is 5% to 25% by mass.

[0018] In other embodiments of the present application, the bioactive glass includes the following raw materials in mass percentage: SiO2 40% to 60%, CaO 20% to 30%, P2O 55% to 12%, Na2O 8% to 13%, ZnO 0.5% to 1.5%, SnO2 0.5% to 1.5%, SrO 0.5% to 1.5% and F 0.5% to 1.5%.

[0019] In other embodiments of the present application, the second paste further includes a soluble potassium salt, and the amount of the soluble potassium salt added is 2% to 15% by mass.

[0020] In other embodiments of the present application, the amount of soluble potassium salt added to the second paste is 5% to 15% by mass.

[0021] In other embodiments of the present application, the soluble potassium salt includes at least one of potassium nitrate, potassium chloride or potassium fluoride.

[0022] In other embodiments of the present application, the first paste further comprises: a whitening and stain removing component;

[0023] Optionally, the whitening and stain removing ingredients include: peroxide;

[0024] Optionally, in the first paste, the amount of peroxide added is 2% to 10% by mass; and in terms of hydrogen peroxide content, the hydrogen peroxide content is less than 2%;

[0025] Optionally, the peroxide comprises: at least one of hydrogen peroxide or a complex of hydrogen peroxide;

[0026] Optionally, the hydrogen peroxide complex comprises at least one of a polyvinyl pyrrolidone-hydrogen peroxide complex or urea peroxide.

[0027] In other embodiments of the present application, the second paste further includes: a low-valent metal salt;

[0028] Optionally, the low-valent metal salt comprises a stannous salt;

[0029] Optionally, the stannous salt includes: at least one of stannous chloride or stannous fluoride;

[0030] Optionally, in the second paste, the amount of low-valent metal salt added is 0.01% to 0.45% by mass.

[0031] In other embodiments of the present application, the second paste further comprises: alkaline salts;

[0032] Optionally, in the second paste, the amount of alkaline salt added is 0.6% to 8% by mass;

[0033] Optionally, the alkaline salt includes: at least one of a carbonate or a bicarbonate;

[0034] Optionally, the carbonate includes at least one of sodium carbonate or potassium carbonate; the bicarbonate includes at least one of sodium bicarbonate, potassium bicarbonate, magnesium bicarbonate or calcium bicarbonate.

[0035] In other embodiments of the present application, the second paste includes the carbonate and the bicarbonate;

[0036] In terms of mass percentage, in the second paste, the amount of carbonate added is 0.1% to 3.0%; the amount of bicarbonate added is 0.5% to 5%; or

[0037] The second paste includes the carbonate; in terms of mass percentage, the amount of the carbonate added to the second paste is 0.1% to 8.0%; or

[0038] The second paste includes the bicarbonate; in the second paste, the amount of the bicarbonate added is 0.5% to 8.0% by mass.

[0039] In other embodiments of the present application, the second paste further includes: an anionic foaming agent;

[0040] Optionally, in the second paste, the amount of anionic foaming agent added is 2% to 5% by mass;

[0041] Optionally, the anionic foaming agent includes at least one of sodium lauryl sulfate, sodium lauryl sarcosinate or sodium methyl cocoyl taurate.

[0042] In other embodiments of the present application, the second paste further comprises: betaine;

[0043] Optionally, in the second paste, the amount of betaine added is 0.2% to 5.0% by mass percentage;

[0044] Optionally, the betaines include at least one of trimethylglycine, trialkylammonium inner salt, tetramethylammonium hydroxide or tetramethylammonium hydroxide.

[0045] In other embodiments of the present application, the first paste includes: carboxymethyl chitosan;

[0046] Optionally, in the first paste, the amount of carboxymethyl chitosan added is 0.1% to 2.0% by mass.

[0047] In other embodiments of the present application, the first paste and the second paste further include: a soluble zinc salt;

[0048] Optionally, in terms of mass percentage, the amount of soluble zinc salt added to the first paste or the second paste is 0.12% to 0.38%;

[0049] Optionally, the soluble zinc salt includes at least one of zinc citrate, zinc chloride or zinc fluoride.

[0050] In other embodiments of the present application, the first carrier includes: a moisturizer, a thickener, a friction agent, and an emulsifier;

[0051] Optionally, the first paste comprises, by mass percentage: 61%-85% moisturizer, 4.3%-11% thickener, 5%-10% abrasive, 1%-8% emulsifier; 0.12%-0.38% soluble zinc salt;

[0052] Optionally, the moisturizer includes: at least one of propylene glycol, polyethylene glycols or glycerin;

[0053] Optionally, the thickener includes: at least one of thickening silicon dioxide or polyvinyl pyrrolidone;

[0054] Optionally, the friction agent includes: at least one of calcium pyrophosphate or friction-type silica;

[0055] Optionally, emulsifiers include: PEG-60 hydrogenated castor oil.

[0056] In other embodiments of the present application, the second carrier includes: a humectant, a thickener, an appearance improver, an abrasive; and optionally, a soluble zinc salt;

[0057] Optionally, the humectant includes: at least one of glycerin, sorbitol, glycerol, polyethylene glycols or propylene glycol;

[0058] Optionally, the thickener includes at least one of xanthan gum, carbomer, carrageenan, cellulose gum, hydroxyethyl cellulose, thickening silicon dioxide or polyvinyl pyrrolidone;

[0059] Optionally, the appearance improver includes: titanium dioxide;

[0060] Optionally, the friction agent includes at least one of friction-type silica, calcium hydrogen phosphate, calcium carbonate or calcium pyrophosphate.

[0061] Optionally, the soluble zinc salt includes at least one of zinc citrate, zinc chloride or zinc fluoride.

[0062] In other embodiments of the present application, the second paste includes, by mass percentage:

[0063] 5%~25% water, 2%~15% soluble potassium salt, 35%-60% moisturizer, 4.5%-12.5% ​​thickener, 0.2%-0.8% appearance improver, 5%-15% abrasive; 0.12%~0.38% soluble zinc salt;

[0064] In other embodiments of the present application, the extrusion container further comprises: a cover plate, a transmission extrusion structure and a partition plate;

[0065] The partition is arranged in the chamber, and is used to divide the chamber into at least two sub-chambers along the extension direction of the container body, and the sub-chambers are communicated with the outlet of the container body;

[0066] The cover plate is detachably connected to the tail of the container body through a connecting structure to perform sealing;

[0067] The transmission extrusion structure is arranged in the container body and is movably connected to the cover plate. The transmission extrusion structure is used to extrude the first paste and the second paste in the chamber from the outlet.

[0068] In other embodiments of the present application, the transmission extrusion structure includes: a transmission member and a piston, one end of the transmission member is movably connected to the cover plate, the transmission member is arranged in the chamber along the extension direction of the container body, the piston is transmission-connected to the transmission member, and the transmission member drives the piston forward or backward along the extension direction of the axis of the transmission member to realize the extrusion of the first paste and the second paste.

[0069] In other embodiments of the present application, a toothpaste for resisting dentin sensitivity includes: a base;

[0070] The base comprises: a base body;

[0071] A driving component is disposed in the base body;

[0072] The transmission structure is arranged in the base body and connected to the driving component; the transmission structure is provided with a docking component, and the docking component is used to be fixedly connected with the transmission extrusion structure in the extrusion container when the base is assembled with the extrusion container; the driving component drives the transmission structure, and then drives the transmission extrusion structure fixedly connected to the docking component to realize the extrusion of the first paste and the second paste;

[0073] A control module is disposed in the base body and is electrically connected to the driving component;

[0074] The power supply module is arranged in the base body and is electrically connected to the control module and the driving component respectively.

[0075] In other embodiments of the present application, the transmission structure includes: a bracket and a transmission member; the transmission member is arranged on the bracket, the output end of the driving member passes through the bracket, and the output end of the driving member is connected to the transmission member, and the docking member is arranged on one end of the transmission member away from the output end of the driving member.

[0076] In a second aspect, the present application provides a method for preparing a toothpaste for resisting dentin sensitivity.

[0077] Extruding a container, a first paste, and a second paste;

[0078] The extrusion container comprises: a container body;

[0079] The container body comprises at least two sub-chambers along the extension direction thereof, and the first paste and the second paste are respectively contained in one of the sub-chambers;

[0080] The first paste comprises: bioactive glass and a first carrier acceptable to toothpaste, and the first paste does not contain water; the second paste comprises: water and a second carrier acceptable to toothpaste;

[0081] The preparation method comprises:

[0082] A first paste is injected into one sub-chamber; and a second paste is injected into another sub-chamber.

[0083] In other embodiments of the present application, the amount of soluble potassium salt added to the second paste is 2% to 15% by mass.

[0084] In a fourth aspect, the present application provides a method for combating dentin hypersensitivity.

[0085] Provided is a toothpaste for resisting dentin sensitivity, the toothpaste for resisting dentin sensitivity comprising:

[0086] Extruding a container, a first paste, and a second paste;

[0087] The extrusion container comprises: a container body;

[0088] The container body comprises at least two sub-chambers along the extension direction thereof, and the first paste and the second paste are respectively contained in one of the sub-chambers;

[0089] The first paste comprises: bioactive glass and a first carrier acceptable to toothpaste, and the first paste does not contain water; the second paste comprises: water and a second carrier acceptable to toothpaste;

[0090] Methods include:

[0091] When the first paste and the second paste are squeezed out, the first paste and the second paste are applied to an oral care appliance; and the oral care appliance is used to clean the oral cavity. BRIEF DESCRIPTION OF THE DRAWINGS

[0092] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present application and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.

[0093] Figure 1 This is a schematic diagram of the structure of a toothpaste for resisting dentin sensitivity according to an embodiment of the present application;

[0094] Figure 2 This is a schematic structural diagram of an extrusion container according to an embodiment of the present application;

[0095] Figure 3A structural schematic diagram of a base from one perspective of an embodiment of the present application;

[0096] Figure 4 This is a structural schematic diagram of the base from another perspective of the embodiment of the present application;

[0097] Figure 5 The surface morphology of bovine teeth after acid etching corresponding to Example 1 is shown;

[0098] Figure 6 The surface morphology of bovine teeth after acid etching corresponding to Example 3 is shown;

[0099] Figure 7 The surface morphology of bovine teeth after acid etching corresponding to Example 5 is shown;

[0100] Figure 8 The surface morphology of bovine teeth after acid etching corresponding to Comparative Example 1 is shown;

[0101] Fig. 9 The surface morphology of bovine teeth after acid etching corresponding to Comparative Example 2 is shown;

[0102] Fig.10 The surface morphology of bovine teeth under a 1k-fold electron microscope after the plugging experiment corresponding to Example 1 is shown;

[0103] Fig.11 The surface morphology of bovine teeth under a 1k-fold electron microscope after the plugging experiment corresponding to Example 3 is shown;

[0104] Fig.12 The surface morphology of bovine teeth under a 1k-fold electron microscope after the plugging experiment corresponding to Example 5 is shown;

[0105] Fig.13 The surface morphology of bovine teeth under a 1k-fold electron microscope after the plugging experiment corresponding to Comparative Example 1 is shown;

[0106] Fig.14 The surface morphology of bovine teeth under a 1k-fold electron microscope after the plugging experiment corresponding to Comparative Example 2 is shown;

[0107] Fig.15 The surface morphology of bovine teeth after acid etching corresponding to Example 1 is shown;

[0108] Fig.16 The surface morphology of bovine teeth after acid etching corresponding to Example 2 is shown;

[0109] Fig.17 The surface morphology of bovine teeth under a 1k-fold electron microscope after the plugging experiment corresponding to Example 1 is shown;

[0110] Fig.18 The surface morphology of bovine teeth under a 1k-fold electron microscope after the plugging experiment corresponding to Example 2 is shown;

[0111] Fig.19 The mechanism of bioactive glass-induced hydroxyapatite formation is shown.

[0112] Icons: 1-anti-dentin sensitivity toothpaste; 10-extrusion container; 100-container body; 200-cover; 130-partition; 110-chamber; 120-outlet; 111-subchamber; 300-connecting structure; 410-transmission member; 420-piston; 11-base; 12-base body; 13-driving member; 14-transmission structure; 15-docking member; 16-extension; 141-bracket; 142-transmission member; 800-cap body; 1500-snap assembly. DETAILED DESCRIPTION

[0113] In order to make the purpose, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments.

[0114] Therefore, the following detailed description of the embodiments of the present application is not intended to limit the scope of the present application for protection, but merely represents selected embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present application.

[0115] Some embodiments of the present application provide a toothpaste for resisting dentin sensitivity, comprising:

[0116] Extruding a container, a first paste, and a second paste;

[0117] The extrusion container comprises: a container body;

[0118] The container body includes at least two sub-chambers along the extension direction, and the first paste and the second paste are respectively contained in one sub-chamber; the first paste includes: bioactive glass and a first carrier acceptable to toothpaste, and the first paste does not contain water; the second paste includes: water and a second carrier acceptable to toothpaste.

[0119] The above technical scheme of the present application provides a new toothpaste against dentin sensitivity that is "mixable and ready to use", wherein the first paste includes: bioactive glass; the second paste includes water; during the use stage, the first paste and the second paste are squeezed out from the toothpaste outlet; the first paste and the second paste are not pre-mixed, but are mixed by brushing when acting on the oral cavity. At this time, the water in the second paste becomes an effective ingredient, and as an important promoter of bioactive glass, it can quickly activate the release of the activity of bioactive glass and enhance the activity of bioactive glass. The activated bioactive glass can target mineralization and block exposed dentin, thereby fundamentally improving the problem of dentin sensitivity.

[0120] Reference Figure 1~Figure 4 Some embodiments of the present application provide a toothpaste 1 for resisting dentin sensitivity, comprising:

[0121] Extrusion container 10, first paste (not shown), second paste (not shown);

[0122] The extrusion container 10 comprises: a container body 100, a cover plate 200, a transmission extrusion structure and a partition plate 130;

[0123] The container body 100 is provided with a chamber 110, and an outlet 120 is provided on the container body 100, and the outlet 120 is communicated with the chamber 110; a partition 130 is provided in the chamber 110, and the partition 130 is used to divide the chamber 110 into at least two sub-chambers 111 along the extension direction of the container body 100, and the sub-chambers 111 are communicated with the outlet 120; the first paste and the second paste are respectively contained in one sub-chamber 111;

[0124] The cover plate 200 is detachably connected to the rear portion of the container body 100 through the connection structure 300 for sealing;

[0125] The transmission extrusion structure is disposed in the container body 100 and is movably connected to the cover plate 200. The transmission extrusion structure is used to extrude the first paste and the second paste in the chamber 110 from the outlet 120.

[0126] The first paste comprises: bioactive glass and a first carrier acceptable to toothpaste, and the first paste does not contain water; the second paste comprises: water and a second carrier acceptable to toothpaste.

[0127] In the above technical solution, the first paste includes: bioactive glass, and the first paste does not contain water; the second paste includes: soluble potassium salt, and the second paste contains water.

[0128] The above technical scheme of the present application provides a new toothpaste against dentin sensitivity that can be mixed and used immediately. The first paste includes: bioactive glass; the second paste includes water; during the use stage, the first paste and the second paste are squeezed out from the toothpaste outlet through the transmission extrusion structure; the first paste and the second paste are not mixed, but are mixed by brushing when acting on the oral cavity. At this time, the water in the second paste becomes an effective ingredient, and as an important promoter of bioactive glass, it can quickly activate the release of the activity of bioactive glass and enhance the activity of bioactive glass. The activated bioactive glass can target mineralization and block exposed dentin, thereby fundamentally improving the problem of dentin sensitivity.

[0129] Furthermore, bioactive glass can quickly exchange ions with human body fluids, and through a series of reactions, form a hydroxyapatite layer on the surface that is similar to the composition of bone tissue, thereby forming a stable chemical bond with human bone tissue or soft tissue to induce bone tissue regeneration; the mechanism of bioactive glass inducing the formation of hydroxyapatite is as follows Fig.19 As shown:

[0130] This determines that if bioactive glass is to remain active in the formulation system, it must be in the absence of water.

[0131] In the current prior art, the bioactive glass is applied to anhydrous formulas. However, the anhydrous formula toothpaste has poor taste such as bubbles, resulting in poor decontamination ability of the toothpaste.

[0132] However, after extensive research in the present application, it was found that when the first paste includes: bioactive glass, and the first paste does not contain water; the second paste includes: soluble potassium salt, and the second paste contains water; that is, the bioactive glass and water are stored separately during the storage stage, the activity of the bioactive glass can be preserved; but during the use stage, water can promote the activity of the bioactive glass; that is, when the present application scheme is "mix and use", the "water" in the second paste becomes an effective ingredient, which can be used as an important promoter of bioactive glass to promote the efficacy of bioactive glass, and can quickly activate the release of the activity of the bioactive glass when "mix and use".

[0133] Furthermore, the "mix and use" solution of the present application also avoids the problems of difficult foaming, poor taste and poor cleaning ability of the single-tube anhydrous bioactive glass formula.

[0134] Furthermore, in some embodiments of the present application, the amount of bioactive glass added to the first paste is 1% to 10% by mass.

[0135] Furthermore, in some embodiments of the present application, the amount of water added to the second paste is 5% to 25% by mass.

[0136] In the above technical solution, by setting the addition amount of bioactive glass and water within the above range, the activity release of the bioactive glass can be further promoted in the "mix and use" stage. The minimum addition amount of 1g for the efficacy of the bioactive glass is measured, and the water-containing formula containing more than 5% deionized water can activate its activity within 2 minutes to complete the release.

[0137] Further optionally, exemplarily, in some embodiments of the present application, in the first paste, the amount of bioactive glass added is 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10% or a range between any two of the foregoing values, measured in mass percentage.

[0138] Further optionally, exemplarily, in some embodiments of the present application, the amount of water added to the second paste is 5%, 8%, 9%, 10%, 11%, 12%, 15%, 18%, 20%, 21%, 22%, 23%, 25% or a range between any two of the foregoing values, measured in mass percentage.

[0139] Furthermore, in some embodiments of the present application, the bioactive glass includes the following raw materials in mass percentage: SiO2 40% to 60%, CaO 20% to 30%, P2O 55% to 12%, Na2O 8% to 13%, ZnO 0.5% to 1.5%, SnO2 0.5% to 1.5%, SrO 0.5% to 1.5% and F 0.5% to 1.5%.

[0140] The above-mentioned bioactive glass contains trace elements such as fluorine, strontium, zinc, etc., which is more conducive to resisting dentin sensitivity. During the use stage, the first paste, the second paste, artificial saliva and the water-containing components in the second paste can quickly generate a large amount of hydroxyapatite, and dissolve zinc, tin, strontium and fluorine elements, which are beneficial to the health of oral teeth.

[0141] Furthermore, in some embodiments of the present application, the above-mentioned bioactive glass can be prepared by referring to the preparation method in Chinese Patent No. 201811369263.4.

[0142] Furthermore, in some embodiments of the present application, the second paste further includes: soluble potassium salt; in terms of mass percentage, the amount of soluble potassium salt added to the second paste is 2% to 15%.

[0143] In the above technical solution, the second paste includes: soluble potassium salt, which can reduce the sensitivity of dentin and dental pulp nerve endings, thereby alleviating dentin sensitivity and achieving the effect of "curing the symptoms". Furthermore, the first paste includes: bioactive glass; bioactive glass can quickly exchange ions with human body fluids in human body fluids, and form a hydroxyapatite layer similar to the composition of bone tissue on the surface through a series of reactions, thereby forming a stable chemical bond with the bone tissue or soft tissue of the human body, inducing bone tissue regeneration, and its action on teeth can achieve targeted effect on dentin to form a stable inorganic blocking layer, thereby fundamentally achieving resistance to dentin sensitivity and achieving the effect of "curing the root cause". Combining the two, the anti-dentin sensitivity toothpaste of the present application can achieve the effect of "curing the symptoms and the root cause", and truly achieve resistance to dentin sensitivity.

[0144] Furthermore, in some embodiments of the present application, the amount of soluble potassium salt added to the second paste is 5% to 15% by mass.

[0145] In the above technical solution, by setting the addition amount of soluble potassium salt within the above range, the sensitivity of dentin and dental pulp nerve endings can be effectively reduced, thereby alleviating dentin sensitivity.

[0146] Furthermore, when the amount of soluble potassium salt added is 5% to 15%, it can greatly enhance the effect of reducing the sensitivity of dentin and pulp nerve endings, thereby alleviating dentin sensitivity.

[0147] The potassium-containing single desensitizing toothpaste currently on the market usually has a potassium content concentration of no more than 5%, and has limited effect on alleviating dentin sensitivity. This is because the potassium content of this conventional single-tube toothpaste cannot be increased any further. If it continues to increase, on the one hand, it will lead to an increase in the overall salt content of the formula system. Compared with the low-potassium system, high salt will destroy the colloid stability in the paste, and the shelf life of the product will be greatly reduced; on the other hand, the addition of high concentrations of acid radicals will also increase the oxidation of the acid radicals due to high temperature or reduced paste pH during product storage, increase the reaction of flavors or other active ingredients in the formula system, and lead to the destruction of paste stability and changes in taste or appearance.

[0148] In the above technical solution of the present application, the second paste includes: soluble potassium salt, and the second paste contains water; that is, the soluble potassium salt is set in the water-containing formula, which can increase the potassium salt concentration in the system, improve the effect of alleviating dentin sensitivity, and do not affect the stability of the paste. At the same time, it also achieves the effect of promoting the active release of the bioactive glass in the first paste in the "mix and use" stage.

[0149] Exemplarily, in some embodiments of the present application, the amount of soluble potassium salt added to the second paste is 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15% or a range between any two of the foregoing values, measured in mass percentage.

[0150] Furthermore, in some embodiments of the present application, the soluble potassium salt includes at least one of potassium nitrate, potassium chloride or potassium fluoride.

[0151] For example, in some embodiments of the present application, the soluble potassium salt is selected from: any one of potassium nitrate, potassium chloride or potassium fluoride; or in some embodiments of the present application, the soluble potassium salt is selected from: a mixture of potassium nitrate and potassium chloride; the raw materials in the mixture can be mixed in any proportion.

[0152] Furthermore, in the above technical solution, the first paste and the second paste in the chamber 110 are sealed by connecting the cover plate 200 to the tail of the extrusion container 10. By arranging a transmission extrusion structure for extruding the first paste and the second paste in the container body 100, relying on the connection between the cover plate 200 and the transmission extrusion structure, the cover plate 200 can play a role in positioning and supporting the transmission extrusion structure in the process of extruding the material from the outlet, so that the transmission extrusion structure can extrude the first paste and the second paste from the outlet more stably and efficiently. The sealing effect of the cover plate 200 can improve the problem of leakage of the first paste and the second paste from the chamber 110 when the transmission extrusion structure extrude the first paste and the second paste, reduce the risk of failure of the extrusion container 10, and improve the working efficiency of the extrusion container 10 in extruding the first paste and the second paste.

[0153] Furthermore, in the above technical solution, the first paste and the second paste are squeezed out from the outlet of the chamber 110 to form a complete and shaped paste (the first paste and the second paste are in contact and connected together, but can be clearly distinguished); during the use stage, it can ensure that the user applies the first paste and the second paste in the oral cavity at the same time, and it is more conducive to the first paste and the second paste to be mixed evenly in the oral cavity; it can also utilize the release of active ingredients in the oral cavity, which is more conducive to enhancing the effect of anti-dentin sensitivity.

[0154] Furthermore, in the above technical solution, the first paste and the second paste are "mixed and used immediately", which is gentler, more suitable for the oral environment, and more conducive to protecting the oral mucosa. Assuming a scenario, only a single tube of ordinary anhydrous anti-sensitivity toothpaste containing bioactive glass is used, and potassium nitrate (such as powder or solution) is added to the ordinary anhydrous anti-sensitivity toothpaste during the use stage; this form will cause greater irritation, which is not conducive to the oral mucosa or has a particularly bad taste, and is difficult to use for decontamination; it also makes it very troublesome to use, and the actual application value is greatly reduced; once again, assuming that in another scenario, two active substances (such as bioactive glass and potassium nitrate powder or potassium nitrate solution) are directly used in the oral cavity; it will also cause great irritation, which is very not conducive to the oral mucosa or has a particularly bad taste, and is difficult to use for decontamination; it also makes it very troublesome to use, and the actual application value is greatly reduced.

[0155] Further optionally, in some embodiments of the present application, the sub-chambers 111 are provided in two, and the first paste and the second paste are each contained in one sub-chamber 111 .

[0156] In other optional embodiments of the present application, the above-mentioned sub-chambers 111 can be optionally set to three, four or five, etc., but the first paste and the second paste are always located in two independent sub-chambers 111; the remaining sub-chambers 111 can be set according to actual needs; illustratively, other sub-chambers 111 can accommodate other pastes; or other non-paste materials (such as water, etc.); or blank settings (for example, they can be left empty for personalized use by users, etc.).

[0157] Furthermore, in some embodiments of the present application, the second paste includes: an anionic foaming agent.

[0158] Furthermore, in some embodiments of the present application, the anionic foaming agent includes at least one of sodium lauryl sulfate, sodium lauryl sarcosinate or sodium methyl cocoyl taurate.

[0159] Anionic foaming agents can easily combine with calcium ions released by bioactive glass when it comes into contact with water to form soap scum-like components that are insoluble in water, resulting in a decrease in the active content of bioactive glass in the paste during storage; in addition, the consumption of anionic foaming agents will also lead to a decrease in the amount of foam during brushing, thereby weakening its ability to remove dirt in the oral cavity.

[0160] In the above technical solution, since the anionic foaming agent is arranged in the second paste and isolated from the bioactive glass in the first paste, the loss of the activity of the anionic foaming agent to the bioactive glass is avoided. At the same time, the use of anionic foaming agent in the second paste containing water can effectively improve the overall foaming effect of the toothpaste, improve the decontamination ability, and enhance the taste of use; effectively solving the problems of poor taste, poor foaming, and poor decontamination of anhydrous bioactive glass toothpaste in the prior art.

[0161] Furthermore, in some embodiments of the present application, the amount of anionic foaming agent added to the second paste is 2% to 5% by mass.

[0162] Exemplarily, in the second paste, the amount of anionic foaming agent added is 2%, 2.1%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5% or a range between any two of the foregoing values, in percentage by mass.

[0163] Furthermore, in some embodiments of the present application, the second paste also includes: betaines.

[0164] Betaine has the function of moisturizing and relieving mucosal gingival tissues, and can also show excellent antibacterial properties, effectively inhibiting Gram-positive bacteria, Gram-negative bacteria, yeast and mold. It can inhibit dental plaque and protect gums.

[0165] Furthermore, in some embodiments of the present application, in the second paste, the amount of betaine added is 0.2% to 5.0% by mass.

[0166] Within the above content range, it can effectively inhibit dental plaque and protect gums.

[0167] Illustratively, in some embodiments of the present application, in the second paste, the amount of betaine added is 0.2%, 0.3%, 0.5%, 0.8%, 1%, 1.2%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 4.8%, 5.0% or a range between any two of the foregoing values, measured in mass percentage.

[0168] Furthermore, in some embodiments of the present application, the betaines include at least one of trimethylglycine, trialkylammonium inner salt, tetramethylammonium hydroxide or tetramethylammonium hydroxide.

[0169] For example, in some embodiments of the present application, the betaine is selected from any one of trimethylglycine, trialkylammonium inner salt, tetramethylammonium hydroxide or tetramethylammonium hydroxide. Or the betaine is selected from a mixture of trimethylglycine and trialkylammonium inner salt, and each substance in the mixture can be mixed in any proportion.

[0170] Furthermore, in some embodiments of the present application, the first paste also includes: carboxymethyl chitosan.

[0171] In the above technical solution, carboxymethyl chitosan can increase the retention of effective ingredients. In addition, carboxymethyl chitosan, like betaine, is rich in unique ammonium ions and exhibits excellent antibacterial properties, and can effectively inhibit Gram-positive bacteria, Gram-negative bacteria, yeast and mold. The two work synergistically to inhibit dental plaque and protect gums.

[0172] Furthermore, in some embodiments of the present application, in the first paste, the amount of carboxymethyl chitosan added is 0.1% to 2.0% by mass. Within the above content range, the effect of inhibiting dental plaque and protecting gums can be effectively exerted.

[0173] Illustratively, in some embodiments of the present application, in the first paste, the amount of carboxymethyl chitosan added is 0.1%, 0.2%, 0.5%, 0.8%, 1%, 1.2%, 1.3%, 1.5%, 1.8%, 2.0% or a range between any two of the foregoing values, measured in mass percentage.

[0174] Furthermore, in some embodiments of the present application, the first paste includes: whitening and stain-removing ingredients.

[0175] In the above technical solution, by adding whitening and stain removal ingredients into the first paste, the organic isolation layer tooth stains can be removed, which is conducive to creating conditions for the active ingredient bioactive glass to target and form a stable inorganic blocking layer.

[0176] Furthermore, in some embodiments of the present application, the whitening and stain-removing ingredients include: peroxide.

[0177] Furthermore, in some embodiments of the present application, in the first paste, the amount of peroxide added is 2% to 10% by mass; and in terms of hydrogen peroxide content, the hydrogen peroxide content is less than 2%.

[0178] Furthermore, in some embodiments of the present application, the peroxide includes at least one of hydrogen peroxide or a complex of hydrogen peroxide.

[0179] Furthermore, in some embodiments of the present application, the hydrogen peroxide complex includes at least one of a polyvinyl pyrrolidone-hydrogen peroxide complex or urea peroxide.

[0180] Furthermore, in some embodiments of the present application, the second paste also includes: a low-valent metal salt.

[0181] After peroxide comes into contact with low-valent metal salts, a Fenton-like reaction can occur to generate free hydroxyl groups, which act on teeth to achieve an enhanced whitening effect. Putting the two in two pastes is conducive to avoiding premature reaction and loss of activity between the two, and is conducive to the Fenton-like reaction between peroxide and low-valent metal salts in the "mix and use" stage to generate free hydroxyl groups, which act on teeth to remove organic isolation layer stains, improve the subsequent targeted sealing effect of bioactive glass, and improve the effect of resisting dentin sensitivity.

[0182] Furthermore, in some embodiments of the present application, the low-valent metal salt includes a stannous salt.

[0183] Furthermore, in some embodiments of the present application, the stannous salt includes at least one of stannous chloride or stannous fluoride.

[0184] For example, taking stannous salt as an example, when stannous salt contacts peroxide, the following Fenton-like reaction can occur:

[0185]

[0186] From the above reaction, it can be seen that after stannous salt comes into contact with peroxide, a Fenton-like reaction occurs to generate free hydroxyl groups, which can effectively remove organic isolation layer stains on teeth, improve the subsequent targeted sealing effect of bioactive glass, and improve the effect of resisting dentin sensitivity.

[0187] Furthermore, in some embodiments of the present application, in the second paste, the amount of low-valent metal salt added is 0.01% to 0.45% by mass.

[0188] In the above technical solution, the addition amount of the low-valent metal salt in the second paste is 0.01%~0.45%; it can further achieve synergistic effect with the peroxide in the first paste when "mix and use" is achieved, and exert an enhanced whitening effect.

[0189] Illustratively, in some embodiments of the present application, the amount of low-valent metal salt added is 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.1%, 0.2%, 0.3%, 0.35%, 0.4%, 0.41%, 0.42%, 0.43%, 0.44%, 0.45% or a range between any two of the foregoing values.

[0190] Furthermore, in some embodiments of the present application, the second paste also includes: alkaline salts.

[0191] Alkaline salts are beneficial for the removal of bacteria and organic stains from damaged tooth sites by active oxygen, and are conducive to creating conditions for the targeted action of the active ingredient bioactive glass to form a stable inorganic sealing layer.

[0192] Further optionally, in some embodiments of the present application, the alkaline salt includes: at least one of carbonate or bicarbonate.

[0193] Carbonates or bicarbonates are beneficial for active oxygen to remove bacteria and organic stains from damaged tooth sites, and are beneficial for creating conditions for the targeted action of the active ingredient bioactive glass to form a stable inorganic sealing layer.

[0194] Furthermore, the combination of alkaline salts and peroxides is beneficial for the active oxygen removal of bacteria and organic stains from damaged teeth. The high-efficiency active oxygen two-component formula removes tooth stains in the organic isolation layer, creating conditions for the targeted effect to form a stable inorganic sealing layer.

[0195] Exemplarily, the reaction of the above-mentioned alkaline salts with peroxide is as follows:

[0196]

[0197] It can be seen from the above reaction formula that hydrogen peroxide reacts with sodium bicarbonate to generate peroxyl radicals, which enhance the effect of removing tooth stains in the organic isolation layer compared to single hydrogen peroxide.

[0198] Furthermore, in some embodiments of the present application, the carbonate includes at least one of sodium carbonate or potassium carbonate; the bicarbonate includes at least one of sodium bicarbonate, potassium bicarbonate, magnesium bicarbonate or calcium bicarbonate.

[0199] For example, in some embodiments of the present application, the carbonate is selected from either sodium carbonate or potassium carbonate; or in some embodiments of the present application, the carbonate is selected from a mixture of sodium carbonate and potassium carbonate; the raw materials in the mixture can be mixed in any proportion.

[0200] For example, in some embodiments of the present application, the bicarbonate is selected from any one of sodium bicarbonate, potassium bicarbonate, magnesium bicarbonate or calcium bicarbonate. Or in some embodiments of the present application, the above-mentioned bicarbonate is selected from a mixture of sodium bicarbonate, potassium bicarbonate, magnesium bicarbonate and calcium bicarbonate; or in some embodiments of the present application, the above-mentioned bicarbonate is selected from a mixture of sodium bicarbonate and potassium bicarbonate; or in some embodiments of the present application, the above-mentioned bicarbonate is selected from a mixture of magnesium bicarbonate and calcium bicarbonate; or in some embodiments of the present application, the above-mentioned bicarbonate is selected from a mixture of sodium bicarbonate, potassium bicarbonate and magnesium bicarbonate; each raw material in the mixture can be mixed in any proportion.

[0201] Furthermore, in some embodiments of the present application, the amount of alkaline salt added to the second paste is 0.6% to 3.5% by mass.

[0202] In the above technical solution, the amount of alkaline salt added to the second paste is 0.6%~3.5%; it can further synergize with the aforementioned peroxide to further improve the whitening effect.

[0203] Illustratively, in some embodiments of the present application, the amount of alkaline salt added is 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.5%, 1.6%, 1.8%, 2%, 2.2%, 2.5%, 2.8%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5% or a range between any two of the foregoing values.

[0204] Furthermore, in some embodiments of the present application, in the second paste, the amount of carbonate added is 0.1% to 8.0% by mass.

[0205] In the above technical solution, in the second paste, the added amount of carbonate is 0.1%~8.0%; it can further synergize with other raw materials such as the aforementioned peroxide to further improve the whitening effect.

[0206] Further, in some embodiments of the present application, the second paste includes the carbonate and the bicarbonate;

[0207] In terms of mass percentage, in the second paste, the added amount of the carbonate is 0.1% to 3.0%; the added amount of the bicarbonate is 0.5% to 5%.

[0208] In the above technical solution, in the second paste, carbonates and bicarbonates can further synergize with other raw materials such as the aforementioned peroxide to further enhance the whitening effect.

[0209] Exemplarily, in some embodiments of the present application, in terms of mass percentage, in the second paste, the addition amount of carbonate is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0% or the range between any two of the foregoing values. Exemplarily, in some embodiments of the present application, in terms of mass percentage, in the second paste, the addition amount of bicarbonate is 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.5%, 1.8%, 2%, 2.5%, 2.8%, 3%, 3.5%, 3.8%, 4%, 4.5%, 4.8%, 5% or the range between any two of the foregoing values.

[0210] Furthermore, in some embodiments of the present application, the second paste includes the carbonate; in terms of mass percentage, the added amount of the carbonate in the second paste is 0.1% to 8.0%.

[0211] Furthermore, in some embodiments of the present application, the second paste includes the bicarbonate; in the second paste, the amount of the bicarbonate added is 0.5% to 8.0% by mass.

[0212] Illustratively, in some embodiments of the present application, in the second paste, the amount of bicarbonate added is 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.5%, 1.8%, 2%, 2.5%, 2.8%, 3%, 3.5%, 3.8%, 4%, 4.5%, 4.8%, 5% or a range between any two of the foregoing values, in percentage by mass.

[0213] Furthermore, in some embodiments of the present application, the first carrier includes: a moisturizer, a thickener, a friction agent, and an emulsifier.

[0214] Furthermore, in some embodiments of the present application, the first paste includes, by mass percentage: 1% to 10% bioactive glass; 61% to 85% moisturizer, 4.3% to 11% thickener, 5% to 10% abrasive, 1% to 8% emulsifier; and 0.12% to 0.38% soluble zinc salt.

[0215] Exemplarily, in some embodiments of the present application, the first paste includes, by mass percentage: 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10% or a range between any two of the foregoing bioactive glass; 61%, 62%, 65%, 68%, 70%, 72%, 75%, 78%, 80%, 82%, 83%, 84%, 85% or a range between any two of the foregoing moisturizing agent; 4.3%, 4.5%, 4.8%, 5%, 5.3%, 6%, 6.3%, 6.5%, 7%, 7.5%, 8%, 8.5%, 9%, 10%, 10.5%, 11% or a range between any two of the foregoing A thickener containing 5%, 6%, 7%, 8%, 9%, 10% or a range between any two of the aforementioned values; an abrasive containing 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8% or a range between any two of the aforementioned values; and an emulsifier containing 0.12%, 0.13%, 0.15%, 0.18%, 0.2%, 0.22%, 0.25%, 0.28%, 0.30%, 0.31%, 0.32%, 0.33%, 0.34%, 0.35%, 0.36%, 0.37%, 0.38% or a range between any two of the aforementioned values.

[0216] Furthermore, in some embodiments of the present application, the moisturizer includes at least one of propylene glycol, polyethylene glycols or glycerin.

[0217] Furthermore, in some embodiments of the present application, the thickener includes: at least one of thickening silicon dioxide or polyvinyl pyrrolidone.

[0218] Furthermore, in some embodiments of the present application, the friction agent includes at least one of calcium pyrophosphate or friction-type silica.

[0219] Further, in some embodiments of the present application, the emulsifier includes: PEG-60 hydrogenated castor oil.

[0220] Furthermore, in some embodiments of the present application, the second carrier includes: a moisturizer, a thickener, an appearance improver, and a friction agent.

[0221] Furthermore, in some embodiments of the present application, the humectant includes at least one of glycerin, sorbitol, glycerol, polyethylene glycols or propylene glycol.

[0222] Furthermore, in some embodiments of the present application, the thickener includes at least one of xanthan gum, cellulose gum, hydroxyethyl cellulose, thickening silicon dioxide or polyvinyl pyrrolidone.

[0223] Furthermore, in some embodiments of the present application, the appearance improver includes: titanium dioxide.

[0224] Furthermore, in some embodiments of the present application, the friction agent includes: at least one of friction-type silica or calcium pyrophosphate.

[0225] Further, in some embodiments of the present application, the second paste includes, by mass percentage:

[0226] 5% to 25% water, 2% to 15% soluble potassium salt, 35% to 60% moisturizer, 4.5% to 12.5% ​​thickener, 0.2% to 0.8% appearance improver, 5% to 15% abrasive; 0.12% to 0.38% soluble zinc salt; illustratively, in some embodiments of the present application, in terms of mass percentage, the second paste includes:

[0227] 5%, 6%, 8%, 10%, 12%, 13%, 15%, 18%, 20%, 21%, 22%, 23%, 24%, 25% or any range between two of the foregoing values ​​of water; 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15% or any range between two of the foregoing values ​​of soluble potassium salt; 35%, 36%, 37%, 38%, 40%, 45%, 50%, 55%, 60% or any range between two of the foregoing values ​​of humectant; 4.5%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12.5% ​​or any range between two of the foregoing values ​​of Thickener of 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8% or the range of any two values ​​of the aforementioned appearance improver; 5%, 6%, 8%, 10%, 11%, 12%, 13%, 14%, 15% or the range of any two values ​​of the aforementioned abrasive; Optionally, 0.12%, 0.13%, 0.15%, 0.18%, 0.2%, 0.22%, 0.25%, 0.28%, 0.30%, 0.31%, 0.32%, 0.33%, 0.34%, 0.35%, 0.36%, 0.37%, 0.38% or the range of any two values ​​of the aforementioned soluble zinc salt. Further optionally, in some embodiments of the present application, the first paste and the second paste may also include: sweeteners; such as: mannitol, sucralose, trichlorogalactose; and flavors.

[0228] Further optionally, the first paste includes, by mass percentage: 0.08-0.2% sucralose; 1-15% mannitol; and 0.8-1.4% flavor.

[0229] Further optionally, the second paste includes, by mass percentage: 0.08-0.2% of galactose added; and 0.8-1.4% of flavor added.

[0230] Furthermore, in some embodiments of the present application, the transmission extrusion structure includes: a transmission member and a piston, one end of the transmission member is movably connected to the cover plate, the transmission member is arranged in the chamber along the extension direction of the container body, the piston is connected to the transmission member, and the transmission member drives the piston forward or backward along the extension direction of the axis of the transmission member to realize the extrusion of the first paste and the second paste.

[0231] Please refer to Figure 2 As shown, in some embodiments of the present application, the transmission extrusion structure includes: a transmission member 410 and a piston 420, one end of the transmission member 410 is movably connected to the cover plate 200, the transmission member 410 is arranged in the chamber 110 along the extension direction of the container body 100, the piston 420 is transmission-connected to the transmission member 410, and the transmission member 410 drives the piston 420 to move forward or backward along the axial extension direction of the transmission member 410 to realize the extrusion of the material.

[0232] In this embodiment, the piston 420 can be driven forward or backward along the axial extension direction of the transmission member 410 by the forward and reverse transmission of the transmission member 410 in the transmission extrusion structure, thereby realizing automatic extrusion of the material in the chamber 110 by the piston 420.

[0233] by Figure 1~Figure 2 Taking the structure of the extrusion container 10 shown as an example, since a partition 130 is provided in the container body 100, the chamber 110 of the container body 100 is divided into two to form two independent sub-chambers 111, and each sub-chamber 111 is used to contain the first paste and the second paste. In order to realize the automatic synchronous extrusion of the toothpaste paste in the two sub-chambers 111 and achieve the purpose of mixing and using, the transmission extrusion structure in this embodiment includes two transmission members 410 and two pistons 420, and each sub-chamber 111 is respectively provided with a transmission member 410 and a piston 420, and the two transmission members 410 can rotate synchronously, thereby driving the two pistons 420 to realize synchronous forward or backward movement, and finally realizing the automatic synchronous extrusion of the toothpaste paste of different components in the two sub-chambers 111.

[0234] In some embodiments of the present application, the transmission extrusion structure may be an electric push rod, at the end of which a piston 420 is disposed, and the electric push rod pushes the piston 420 forward or backward to achieve automatic extrusion of the toothpaste paste.

[0235] Further, refer to Figure 3~Figure 4 In some embodiments of the present application, the toothpaste for resisting dentin sensitivity comprises: a base 11;

[0236] The base 11 includes: a base body 12;

[0237] A driving component 13 is disposed in the base body 12;

[0238] The transmission structure 14 is arranged in the base body 12 and connected to the driving component 13; the transmission structure 14 is provided with a docking component 15, and the docking component 15 is used to be fixedly connected with the transmission extrusion structure in the extrusion container 10 when the base 11 and the extrusion container 10 are assembled; the driving component 13 drives the transmission structure 14, and then drives the transmission extrusion structure fixedly connected to the docking component 15, so as to realize the extrusion of the first paste and the second paste;

[0239] The control module is disposed in the base body 12 and is electrically connected to the driving component 13;

[0240] The power supply module is disposed in the base body 12 and is electrically connected to the control module and the driving component 13 respectively.

[0241] Furthermore, in some embodiments of the present application, the transmission structure 14 includes: a bracket 141 and a transmission member 142; the transmission member 142 is arranged on the bracket 141, the output end of the driving component 13 passes through the bracket 141, and the output end of the driving component 13 is connected to the transmission member 142, and the docking component 15 is arranged on one end of the transmission member 142 away from the output end of the driving component 13.

[0242] Please refer to Figure 1~Figure 4 As shown, a switch is provided on the container body 100, and a plug-in component is provided on the container body. The switch is electrically connected to the plug-in component, and the plug-in component is used to electrically connect with a conductive component on a base mounted in cooperation with the extrusion container 10 to transmit an electrical signal.

[0243] In some embodiments of the present application, after the base and the extrusion container 10 are installed, the driving structure is docked with the transmission extrusion structure in the extrusion container 10. After the user triggers the switch, the circuit between the extrusion container 10 and the base is turned on. The control module sends a control instruction to the driving structure according to the switch signal triggered by the user. The driving structure receives the instruction and drives the transmission extrusion structure to work, and the piston is pushed forward by the rotation of the transmission member 410, thereby realizing the automatic and synchronous extrusion of the first paste and the second paste.

[0244] In some embodiments of the present application, the anti-dentin sensitivity toothpaste 1 further includes: a cap body 800 , and the cap body 800 is connected to the container body 100 .

[0245] In some embodiments of the present application, a snap assembly 1500 is provided on the base body 12 , and the base body 12 is detachably connected to the extrusion container via the snap assembly 1500 .

[0246] In some embodiments of the present application, an extension portion 16 is provided on the base body 12 , a switch and a plug-in component are provided on the extension portion 16 , and the switch is provided on the extension portion 16 and on one end close to the outlet of the extrusion container.

[0247] Some embodiments of the present application provide a method for preparing a toothpaste for resisting dentin sensitivity.

[0248] A toothpaste for resisting dentin sensitivity, comprising: an extrusion container, a first paste, and a second paste;

[0249] The extrusion container comprises: a container body;

[0250] The container body includes at least two sub-chambers along the extension direction, and the first paste and the second paste are respectively contained in one sub-chamber; the first paste includes: bioactive glass and a first carrier acceptable to toothpaste, and the first paste does not contain water; the second paste includes: water and a second carrier acceptable to toothpaste;

[0251] The preparation method comprises:

[0252] A first paste is injected into one sub-chamber; and a second paste is injected into another sub-chamber.

[0253] In some embodiments of the present application, the amount of soluble potassium salt added to the second paste is 2% to 15% by mass.

[0254] Some embodiments of the present application provide a method for resisting dentin hypersensitivity.

[0255] Provided is a toothpaste for resisting dentin sensitivity, the toothpaste for resisting dentin sensitivity comprising:

[0256] Extruding a container, a first paste, and a second paste;

[0257] The extrusion container comprises: a container body;

[0258] The container body includes at least two sub-chambers along the extension direction, and the first paste and the second paste are respectively contained in one sub-chamber; the first paste includes: bioactive glass and a first carrier acceptable to toothpaste, and the first paste does not contain water; the second paste includes: water and a second carrier acceptable to toothpaste;

[0259] Methods include:

[0260] When the first paste and the second paste in the cavity are squeezed out from the outlet, the first paste and the second paste are applied to the oral care appliance; and the oral care appliance is used to clean the oral cavity.

[0261] The features and properties of the present application are further described in detail below in conjunction with the examples, and each raw material used in the examples can be purchased commercially;

[0262] The formula of the first paste or the second paste in each embodiment or comparative example is selected from the following Tables 1 to 10; the first paste and the second paste can be prepared by conventional toothpaste preparation processes in the art.

[0263] Table 1 Anhydrous formula S1-1

[0264]

[0265] Table 2 Water-containing formula S1-2

[0266]

[0267] Table 3 Anhydrous formulation S2-1 (without bioactive glass)

[0268]

[0269] Table 4 Single anhydrous pipe D-1 (bioactive glass + potassium nitrate)

[0270]

[0271] Table 5 Anhydrous formula S3-1 (without whitening ingredients)

[0272]

[0273] Table 6 Water-containing formula S3-2 (without whitening ingredients)

[0274]

[0275] Table 7 Anhydrous formula S4-1

[0276]

[0277] Table 8 Anhydrous formula S5-1

[0278]

[0279] Table 9 Water-containing formula S4-2

[0280]

[0281] Table 10 Water-containing formula S5-2

[0282]

[0283] 1. Appearance dispersion and stability verification

[0284] Appearance performance: After squeezing out 2g of the paste of each formula combination, 4 glass beads with a diameter of 0.5cm were added to each, and after oscillating at 2000r / min for 1min on a vortex oscillator to disperse evenly, the paste was poured into a watch glass to observe the dispersion condition of the paste.

[0285] Accelerated aging test is used to examine the stability of the formula under temperature and humidity conditions different from long-term storage, and to preliminarily predict the quality retention trend of the formula under specified storage conditions. Accelerated test is carried out under certain temperature and humidity test conditions (such as 40℃±2℃, 75%RH±5%RH). According to ISO 11609 international standard, the stability data of three months of accelerated test at 40℃±2℃ and 75%RH±5%RH is compared with the stability data of the corresponding product stored at room temperature for 30 months, see Table 11:

[0286] Table 11

[0287]

[0288] From the data in the above table, it can be seen that the dispersibility of the two-component paste in each embodiment is better than that of the single tube. This is because the calcium lauryl sulfate precipitate layer formed in the single tube dopes or wraps the colloid to form a more resilient colloid group, which weakens its dispersibility, and ultimately causes the active ingredients to not be well released to act on the tooth surface. The poor stability of the single tube is also due to this reason. In addition, the compounding of high salt components makes the thickener colloid unable to stretch well, forming a three-dimensional network structure to maintain the long-term stability of the paste.

[0289] 2. Verification of active ion interference

[0290] The above numbered formulas were prepared and stored for one week, and then prepared into mixed solutions and the concentration of soluble calcium ions was calibrated and verified. Preparation of slurry: 3g of each formula and 6g of the combined sample (accurate to 0.01g) were weighed in a 25mL centrifuge tube, dissolved with 9.6g of water, the mass ratio of toothpaste to water was 1:1.6, and high-speed vortex stirring was performed for 1min until the toothpaste was evenly dispersed, and then centrifuged in a high-speed centrifuge at 8000r / min for 1min, and the supernatant was separated and measured by atomic absorption spectrometry to obtain the data of each group as shown in Table 12:

[0291] Table 12

[0292]

[0293] The above experiments show that, under the condition of maintaining the normal experience of anti-sensitivity toothpaste, the stability of the single tube provided by Comparative Example 2 and the calcium ions released by the bioactive glass in the later use are both poor compared with the various embodiments. This is because in the process of preparing the single tube toothpaste, under the introduction of trace water in some raw materials in the ingredients, the bioactive glass releases calcium ions when it meets water and the foaming agent sodium lauryl sulfate ionizes and releases lauryl sulfate anions when it meets water, which will form a lauryl sulfate calcium precipitate that is difficult to dissolve in water during the stirring process, which leads to the reduction of the foaming performance of the foaming agent and the emulsification of the essence in the formula body, making the stability of the formula system worse and easy to release water and oil; at the same time, the precipitation formed by consuming calcium ions is equivalent to releasing the activity of the bioactive glass in advance, so that the calcium ion concentration detected is low.

[0294] However, since Comparative Example 1 does not contain bioactive glass, no calcium ions are released; the anti-allergic effect is poor and the normal anti-allergic experience cannot be maintained.

[0295] 2. Anti-allergic effect verification

[0296] The toothpastes of various embodiments and comparative examples were used for brushing teeth respectively:

[0297] (1) The bovine teeth in this experiment were fresh. After removing surface pollutants, they were rinsed and placed in deionized water containing 0.05% thymol, and placed in a 4°C refrigerator for use. During the experiment, the preserved fresh bovine teeth were cut into 1cm*1cm*2m cubic tooth slices by a low-speed cutter, and then ground with a grinder and polisher (600# sandpaper) to remove the enamel of the bovine teeth and expose the dentinal tubules. The prepared bovine tooth slices (approximately 0.8cm*0.8cm*1mm) were etched with 6% citric acid solution for 3 minutes, and then the etched bovine teeth were placed in pure water and cleaned in an ultrasonic cleaner for 3 minutes to remove surface substances. After drying at room temperature for 24 hours, they were sent for SEM testing of the permeability of the dentinal tubules.

[0298] 1. Place the tooth piece into the groove of the acrylic plate.

[0299] 2. Take 0.4g of toothpaste and put it on the tooth piece in the groove of the acrylic plate, and then take 0.8g of water and put it into the groove of the acrylic plate.

[0300] 3. Place the acrylic plate on an electronic balance and immediately use an electric toothbrush (oral-B) to simulate brushing for 3 minutes, then let it sit for 2 minutes. Control the balance count to display around 150g.

[0301] 4. After each brushing, use 20 mL of deionized water to clean the teeth in a constant temperature oscillator at 180 rpm for 30 seconds, then take out the tooth pieces and place them in artificial saliva at 37°C.

[0302] 5. Brush your teeth 8 times a day (place the tooth piece in artificial saliva after each brushing), brush for 3 days in total, and simulate brushing for 14 days.

[0303] 6. After the toothbrushing experiment, the samples were shaken and cleaned for 2 minutes and then dried. The bovine dentin samples were dried in a constant temperature box at 25°C for 24 hours and observed by scanning electron microscopy (SEM) after drying.

[0304] The test results are shown in the attached figure of the specification:

[0305] Figure 5 The surface morphology of bovine teeth after acid etching corresponding to Example 1 is shown;

[0306] Figure 6 The surface morphology of bovine teeth after acid etching corresponding to Example 3 is shown;

[0307] Figure 7 The surface morphology of bovine teeth after acid etching corresponding to Example 5 is shown;

[0308] Figure 8 The surface morphology of bovine teeth after acid etching corresponding to Comparative Example 1 is shown;

[0309] Fig. 9 The surface morphology of bovine teeth after acid etching corresponding to Comparative Example 2 is shown;

[0310] Fig.10 The surface morphology of bovine teeth under a 1k-fold electron microscope after the plugging experiment corresponding to Example 1 is shown;

[0311] Fig.11 The surface morphology of bovine teeth under a 1k-fold electron microscope after the plugging experiment corresponding to Example 3 is shown;

[0312] Fig.12 The surface morphology of bovine teeth under a 1k-fold electron microscope after the plugging experiment corresponding to Example 5 is shown;

[0313] Fig.13 The surface morphology of bovine teeth under a 1k-fold electron microscope after the plugging experiment corresponding to Comparative Example 1 is shown;

[0314] Fig.14 The surface morphology of bovine teeth under a 1k-fold electron microscope after the blocking experiment corresponding to Comparative Example 2 is shown.

[0315] It can be seen from the above electron microscope scanning diagram that the scheme of Example 1 almost blocks the dentinal tubules very well, and its effect of blocking the dentinal tubules is significantly better than that of Comparative Example 1 and Comparative Example 2. Comparative Example 1 is better than the one without bioactive glass active ingredients, and has the worst blocking effect. It can only rely on the sodium monofluorophosphate already contained in the formula components to produce a weak blocking behavior; and the blocking effect of the single tube of Comparative Example 2 without water tube is also significantly worse than that of Example 1, which can be used to prove that the premixed paste is prone to loss of activity. The content of bioactive glass without water tube in the double tubes of Example 3 and Example 5 is 1%, and the final blocking effect of Example 5 is better than that of Example 3. The difference in the blocking behavior caused by the two formulas is that the water-containing formula in Example 5 has 25% water, which is much more than the 5% addition in Example 3, and the activated blocking effect of bioactive glass is better. Due to the low content of the main functional component bioactive glass in Examples 3 and 5, their blocking effects are inferior to those of other examples with high bioactive glass content. However, compared with Comparative Example 2, Examples 3 and 5, when the amount of bioactive glass added was extremely low (1%), still had better effects than the blocking effect of Comparative Example 2 with a higher amount of bioactive glass added (3%). It can be seen that the present application solution can reduce the amount of bioactive glass used, and under extremely low conditions, can improve the blocking effect of toothpaste, thereby effectively improving the anti-dentin sensitivity effect of toothpaste.

[0316] (2) The above-mentioned fresh bovine tooth cutting and polishing process was further adopted, and acid etching was performed. After the exposure of the dental tubules of the bovine tooth slice was confirmed by scanning electron microscopy, the bovine tooth was placed in an in vitro oral biofilm model to continuously culture the oral resident bacteria mutans streptococci, gingivalis porphyromonas, salivarius streptococci, sanguis streptococci, and actinomycetes naeslundii. Among them, salivarius streptococci and sanguis streptococci are pioneer bacteria in the formation of oral plaque, and actinomycetes naeslundii can mediate the aggregation of various streptococci in the plaque. Porphyromonas gingivalis can cause gingival inflammation, and mutans streptococci are the main caries-causing bacteria. The simple biofilm formed on the bovine tooth slice in this way should be representative. Then, the dyeing solution prepared in accordance with the standard of "TCOCIA 7-2020 Laboratory Evaluation Method for the Efficacy Evaluation of Toothpaste for Oral Cleaning Care Products to Remove Exogenous Plaques" was used. After dyeing for 2 days, the brushing test operations 1-6 mentioned above were performed, and then the scanning electron microscope was used for testing.

[0317] Fig.15 The surface morphology of bovine teeth after acid etching corresponding to Example 1 is shown;

[0318] Fig.16 The surface morphology of bovine teeth after acid etching corresponding to Example 2 is shown;

[0319] Fig.17 The surface morphology of bovine teeth under a 1k-fold electron microscope after the plugging experiment corresponding to Example 1 is shown;

[0320] Fig.18 The surface morphology of bovine teeth under a 1k-fold electron microscope after the blocking experiment corresponding to Example 2 is shown.

[0321] It can be seen from the above experimental results that both Example 1 and Example 2 achieve effective occlusion of the dentin tubes, which indicates that the solution of the present application can truly achieve "curative treatment" and achieve resistance to dentin hypersensitivity.

[0322] Furthermore, the formula combination of Example 1 uses a small amount of peroxide and a catalytic aid to release free radicals, so that the stains on the tooth surface are oxidized, dissolved and removed, which is more conducive to the mineralization of anti-allergic active ingredients. Example 2 also achieved good blocking, but failed to block the area with a larger exposed dentin diameter. This shows that when the dentin pore diameter is larger, the plaque and stains formed on the pore surface will more seriously block the targeted mineralization blocking effect of the bioactive glass. The small amount of peroxide and catalytic aid compounded in Example 1 can first remove plaque and stains, and then enhance the targeted mineralization blocking effect of the bioactive glass. It is more suitable for dental environments with severe dental plaque and organic isolation layer stains.

[0323] The above description is only the preferred embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A toothpaste for resisting dentin sensitivity, characterized in that: include: An extrusion container, a first paste, and a second paste; the extrusion container comprises: a container body; at least two sub-chambers along the extension direction of the container body, the first paste and the second paste are each contained in one of the sub-chambers; the first paste comprises: bioactive glass and a first carrier acceptable to toothpaste, and the first paste does not contain water; the second paste comprises: water and a second carrier acceptable to toothpaste.

2. The anti-dentin sensitivity toothpaste according to claim 1, characterized in that: In terms of mass percentage, the amount of water added to the second paste is 5% to 25%.

3. The anti-dentin sensitivity toothpaste according to claim 1, characterized in that: In terms of mass percentage, the amount of water added to the second paste is 15% to 25%.

4. The anti-dentin sensitivity toothpaste according to claim 1, characterized in that: In terms of mass percentage, the amount of the bioactive glass added to the first paste is 1% to 10%.

5. The anti-dentin hypersensitivity toothpaste according to claim 1, characterized in that: The bioactive glass comprises the following raw materials by mass percentage: SiO2 40%-60%, CaO 20%-30%, P2O5 5%-12%, Na2O8%-13%, ZnO 0.5%-1.5%, SnO2 0.5%-1.5%, SrO 0.5%-1.5% and F 0.5%-1.5%.

6. The anti-dentin hypersensitivity toothpaste according to claim 1, characterized in that: The second paste further includes: soluble potassium salt; in terms of mass percentage, the added amount of the soluble potassium salt is 2% to 15%.

7. The anti-dentin hypersensitivity toothpaste according to claim 6, characterized in that: In terms of mass percentage, the amount of the soluble potassium salt added to the second paste is 5% to 15%.

8. The anti-dentin hypersensitivity toothpaste according to claim 6, characterized in that: The soluble potassium salt includes at least one of potassium nitrate, potassium chloride or potassium fluoride.

9. The anti-dentin hypersensitivity toothpaste according to claim 1, characterized in that: The first paste also includes: whitening and stain removing ingredients.

10. The anti-dentin hypersensitivity toothpaste according to claim 9, characterized in that: The whitening and stain removing ingredients include: peroxide.

11. The anti-dentin hypersensitivity toothpaste according to claim 10, characterized in that: In terms of mass percentage, in the first paste, the added amount of the peroxide is 2% to 10%; and in terms of hydrogen peroxide content, the hydrogen peroxide content is less than 2%.

12. The anti-dentin hypersensitivity toothpaste according to claim 10, characterized in that: The peroxide includes at least one of hydrogen peroxide or a complex of hydrogen peroxide.

13. The anti-dentin hypersensitivity toothpaste according to claim 12, characterized in that: The hydrogen peroxide complex comprises at least one of a polyvinyl pyrrolidone-hydrogen peroxide complex and urea peroxide.

14. The anti-dentin hypersensitivity toothpaste according to claim 1, characterized in that: The second paste further comprises: a low-valent metal salt.

15. The anti-dentin hypersensitivity toothpaste according to claim 14, characterized in that: The low-valent metal salt includes stannous salt.

16. The anti-dentin hypersensitivity toothpaste according to claim 15, characterized in that: The stannous salt includes at least one of stannous chloride and stannous fluoride.

17. The anti-dentin hypersensitivity toothpaste according to claim 14, characterized in that: In terms of mass percentage, the amount of the low-valent metal salt added to the second paste is 0.01% to 0.45%.

18. The anti-dentin hypersensitivity toothpaste according to claim 1, characterized in that: The second paste also includes alkaline salts.

19. The anti-dentin hypersensitivity toothpaste according to claim 18, characterized in that: In terms of mass percentage, the amount of the alkaline salt added to the second paste is 0.6% to 8%.

20. The anti-dentin hypersensitivity toothpaste according to claim 18, characterized in that: The alkaline salts include at least one of carbonates and bicarbonates.

21. The anti-dentin hypersensitivity toothpaste according to claim 20, characterized in that: The carbonate includes at least one of sodium carbonate or potassium carbonate; the bicarbonate includes at least one of sodium bicarbonate, potassium bicarbonate, magnesium bicarbonate or calcium bicarbonate.

22. The anti-dentin hypersensitivity toothpaste according to claim 20, characterized in that: The second paste includes the carbonate and the bicarbonate; in the second paste, the carbonate is added in an amount of 0.1% to 3.0% by mass; the bicarbonate is added in an amount of 0.5% to 5% by mass; or The second paste includes the carbonate; in terms of mass percentage, the amount of the carbonate added to the second paste is 0.1% to 8.0%; or The second paste includes the bicarbonate; in the second paste, the amount of the bicarbonate added is 0.5% to 8.0% by mass.

23. The anti-dentin hypersensitivity toothpaste according to claim 1, characterized in that: The second paste further comprises: an anionic foaming agent.

24. The anti-dentin hypersensitivity toothpaste according to claim 23, characterized in that: In terms of mass percentage, the amount of the anionic foaming agent added to the second paste is 2% to 5%.

25. The anti-dentin hypersensitivity toothpaste according to claim 23, characterized in that: The anionic foaming agent includes at least one of sodium lauryl sulfate, sodium lauryl sarcosinate or sodium methyl cocoyl taurate.

26. The anti-dentin hypersensitivity toothpaste according to claim 1, characterized in that: The second paste also includes betaines.

27. The anti-dentin hypersensitivity toothpaste according to claim 26, characterized in that: In terms of mass percentage, the added amount of the betaine in the second paste is 0.2% to 5.0%.

28. The anti-dentin hypersensitivity toothpaste according to claim 26, characterized in that: The betaines include at least one of trimethylglycine, trialkylammonium inner salt, tetramethylammonium hydroxide or tetramethylammonium hydroxide.

29. The anti-dentin hypersensitivity toothpaste according to claim 1, characterized in that: The first paste also includes: carboxymethyl chitosan.

30. The anti-dentin hypersensitivity toothpaste according to claim 29, characterized in that: In terms of mass percentage, the added amount of the carboxymethyl chitosan in the first paste is 0.1% to 2.0%.

31. The anti-dentin hypersensitivity toothpaste according to any one of claims 1 to 30, characterized in that: The first carrier includes: a moisturizer, a thickener, a friction agent, an emulsifier; or The first carrier comprises: a moisturizer, a thickener, a friction agent, an emulsifier and a soluble zinc salt.

32. The anti-dentin hypersensitivity toothpaste according to any one of claims 1 to 30, characterized in that: In terms of mass percentage, the first paste includes: 1% to 10% bioactive glass, 61% to 85% moisturizer, 4.3% to 11% thickener, 5% to 10% abrasive, 1% to 8% emulsifier; and 0.12% to 0.38% soluble zinc salt.

33. The anti-dentin hypersensitivity toothpaste according to claim 32, characterized in that: The moisturizing agent includes at least one of propylene glycol, polyethylene glycols, sorbitol or glycerin.

34. The anti-dentin hypersensitivity toothpaste according to claim 32, characterized in that: The thickener comprises: at least one of thickening silicon dioxide, carbomer, xanthan gum, cellulose gum, carrageenan, hydroxyethyl cellulose or polyvinyl pyrrolidone.

35. The anti-dentin hypersensitivity toothpaste according to claim 32, characterized in that: The friction agent includes at least one of calcium hydrogen phosphate, calcium carbonate, calcium pyrophosphate or friction-type silica.

36. The anti-dentin hypersensitivity toothpaste according to claim 32, characterized in that: The emulsifier includes at least one of PEG-60 hydrogenated castor oil and PEG-40 hydrogenated castor oil.

37. The anti-dentin hypersensitivity toothpaste according to claim 32, characterized in that: The soluble zinc salt includes at least one of zinc citrate, zinc chloride or zinc fluoride.

38. The anti-dentin hypersensitivity toothpaste according to any one of claims 1 to 30, characterized in that: The second carrier includes: a moisturizer, a thickener, an appearance improver, and an abrasive; or The second carrier comprises: a moisturizer, a thickener, an appearance improver, an abrasive and a soluble zinc salt.

39. The anti-dentin hypersensitivity toothpaste according to any one of claims 1 to 30, characterized in that: In terms of mass percentage, the second paste comprises: 5%~25% water, 2%~15% soluble potassium salt, 35%-60% humectant, 4.5%-12.5% ​​thickener, 0.2%-0.8% appearance improver, 5%-15% abrasive; 0.12%~0.38% soluble zinc salt.

40. The anti-dentin hypersensitivity toothpaste according to claim 39, characterized in that The moisturizing agent includes at least one of glycerin, sorbitol, glycerol, polyethylene glycols or propylene glycol.

41. The anti-dentin hypersensitivity toothpaste according to claim 39, characterized in that: The thickener comprises at least one of xanthan gum, carbomer, carrageenan, cellulose gum, hydroxyethyl cellulose, thickening silicon dioxide or polyvinyl pyrrolidone.

42. The anti-dentin hypersensitivity toothpaste according to claim 39, characterized in that The appearance improver includes: titanium dioxide.

43. The anti-dentin hypersensitivity toothpaste according to claim 39, characterized in that The friction agent includes at least one of friction-type silica, calcium hydrogen phosphate, calcium carbonate or calcium pyrophosphate.

44. The anti-dentin hypersensitivity toothpaste according to claim 39, characterized in that The soluble zinc salt includes at least one of zinc citrate, zinc chloride or zinc fluoride.

45. The anti-dentin hypersensitivity toothpaste according to any one of claims 1 to 30, characterized in that: The extrusion container also includes: a cover plate, a transmission extrusion structure and a partition plate; The partition is disposed in the chamber, and is used to divide the chamber into at least two sub-chambers along the extension direction of the container body, and the sub-chambers are communicated with the outlet of the container body; The cover plate is detachably connected to the tail of the container body through a connecting structure for sealing; The transmission extrusion structure is disposed in the container body and is movably connected to the cover plate. The transmission extrusion structure is used to extrude the first paste and the second paste in the chamber from the outlet.

46. ​​The anti-dentin hypersensitivity toothpaste according to claim 45, characterized in that The transmission extrusion structure includes: a transmission member and a piston, one end of the transmission member is movably connected to the cover plate, the transmission member is arranged in the chamber along the extension direction of the container body, the piston is transmission-connected to the transmission member, and the transmission member drives the piston to move forward or backward along the extension direction of the axis of the transmission member to realize the extrusion of the first paste and the second paste.

47. The anti-dentin hypersensitivity toothpaste according to claim 45, characterized in that The toothpaste for resisting dentin sensitivity comprises: a base; The base comprises: a base body; A driving component is disposed in the base body; A transmission structure is arranged in the base body and connected to the driving component; a docking component is arranged on the transmission structure, and the docking component is used to be fixedly connected with the transmission extrusion structure in the extrusion container when the base and the extrusion container are assembled; the driving component drives the transmission structure, and then drives the transmission extrusion structure fixedly connected to the docking component to realize the extrusion of the first paste and the second paste; A control module is disposed in the base body and is electrically connected to the driving component; The power supply module is arranged in the base body and is electrically connected to the control module and the driving component respectively.

48. The anti-dentin hypersensitivity toothpaste according to claim 47, characterized in that The transmission structure includes: a bracket and a transmission member; the transmission member is arranged on the bracket, the output end of the driving member passes through the bracket, and the output end of the driving member is connected to the transmission member, and the docking member is arranged on one end of the transmission member away from the output end of the driving member.

49. A method for preparing a toothpaste for resisting dentin sensitivity, characterized in that: The toothpaste for resisting dentin sensitivity comprises: Extruding a container, a first paste, and a second paste; The extrusion container comprises: a container body; The container body comprises at least two sub-chambers along the extension direction thereof, and the first paste and the second paste are respectively contained in one of the sub-chambers; The first paste comprises: bioactive glass and a first carrier acceptable to toothpaste, and the first paste does not contain water; the second paste comprises: water and a second carrier acceptable to toothpaste; The preparation method comprises: The first paste is injected into one of the sub-chambers; and the second paste is injected into another of the sub-chambers.

50. The method for preparing an anti-dentin hypersensitivity toothpaste according to claim 49, characterized in that: In terms of mass percentage, the amount of water added to the second paste is 5% to 25%.

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