Method and computer program product for retina hole localization in three-dimensional eyeball model, and method and computer program product for determining FCB external pressurization position

Abstract

The invention discloses a method and a computer program product for positioning a retinal fissure in a three-dimensional eyeball model and determining an FCB external pressurization position. The method for positioning the retinal fissure comprises the following steps: S1, constructing a three-dimensional eyeball model according to the axis length of a diseased eye of a patient; s2, obtaining the chord length of the diseased eye from the front edge of a crack hole to the concave center of a macular from the two-dimensional fundus photo of the diseased eye of the patient; s3, according to the chord length, the arc length from the front edge of the fracture hole to the cornea center point is calculated in the three-dimensional eyeball model. According to the method, by means of the step S3, the chord length obtained through the two-dimensional fundus photo is used for calculating the arc length from the front edge of the crack hole to the central point of the cornea in the three-dimensional eyeball model, so that the position of the front edge of the crack hole can be obtained through positioning in the three-dimensional eyeball model, and equivalently, the position of the front edge of the crack hole of the eyeball of the patient under the three-dimensional condition is obtained through positioning. And compared with a mode of positioning through a two-dimensional image in the prior art, the method is more accurate.

Description

Technical Field

[0001] The present invention relates to the technical field of retinal break positioning, and in particular to a method and a computer program product for positioning retinal breaks and determining a FCB external pressure position in a three-dimensional eyeball model. Background Art

[0002] Rhegmatogenous retinal detachment is a common blinding vitreoretinal disease. The disease develops rapidly, progresses rapidly, and has a great impact on vision. It requires timely external retinal detachment surgery. Before performing external retinal detachment surgery, it is necessary to determine the location of the hole formed by retinal detachment. Traditionally, experienced ophthalmologists use fundus examination, fundus photography, fundus fluorescein angiography, eye B-ultrasound examination, eye CT examination and other means to locate the hole. Most of the above methods can only obtain a two-dimensional image of the patient's diseased eye, and it is difficult to determine the exact location of the hole. Among them, although eye B-ultrasound can obtain a three-dimensional black and white image, its image resolution is low and it is difficult to meet the requirements of clinical surgical guidance. Therefore, the above positioning methods largely rely on the experience of the ophthalmologist. If the ophthalmologist is inexperienced, the positioning may be inaccurate, affecting the surgical effect. Summary of the invention

[0003] One of the technical problems to be solved by the present invention is how to accurately locate the position of the retinal tear.

[0004] In order to solve one of the above technical problems, the present invention provides a method for locating a retinal hole in a three-dimensional eyeball model, comprising the following steps:

[0005] S1. Construct a three-dimensional eyeball model based on the axial length of the patient's diseased eye;

[0006] S2. Obtain the chord length from the front edge of the retina to the fovea of ​​the affected eye from the two-dimensional fundus photograph of the affected eye of the patient;

[0007] S3. Based on the above chord length, the arc length from the leading edge of the hole to the center point of the cornea is calculated in the three-dimensional eyeball model.

[0008] Furthermore, step S1 specifically uses three-dimensional reconstruction technology to construct a three-dimensional eyeball model.

[0009] Further, step S2 includes:

[0010] S21, obtaining the horizontal diameter of the optic disc of the patient's diseased eye as a reference value of the horizontal diameter of the optic disc;

[0011] S22. Enlarge the fundus photograph of the patient's diseased eye, and convert the straight-line distance from the leading edge of the hole in the fundus photograph of the diseased eye to the fovea maculae to obtain the above-mentioned chord length based on the ratio of the horizontal diameter of the optic disc in the enlarged fundus photograph to the baseline value of the horizontal diameter of the optic disc in the patient's diseased eye.

[0012] Furthermore, step S21 specifically uses an optical coherence tomography device to obtain the horizontal diameter of the optic disc of the patient's diseased eye.

[0013] Further, step S3 includes:

[0014] S31. In the three-dimensional eyeball model, measuring the scleral arc length corresponding to the chord length;

[0015] S32. In the three-dimensional eyeball model, the arc length from the front edge of the hole to the center point of the cornea is calculated based on the above-mentioned scleral arc length.

[0016] Furthermore, in step S32, specifically, the arc length from the front edge of the hole to the center point of the cornea is obtained by subtracting the arc length of the sclera from the semi-arc length of the three-dimensional eyeball model.

[0017] The second technical problem to be solved by the present invention is how to accurately determine the external pressure position of the FCB.

[0018] In order to solve the second of the above technical problems, the present invention provides a method for determining the external pressure-applying position of FCB in a three-dimensional eyeball model. The three-dimensional eyeball model is constructed according to the axial length of the patient's diseased eye. In the three-dimensional eyeball model, the external pressure-applying position of FCB is calculated and determined according to the arc length from the leading edge of the tear to the center point of the cornea, the corneal radius and the preset safety distance from the leading edge of the tear to the root of the FCB drainage tube.

[0019] Furthermore, according to the method for locating retinal breaks in a three-dimensional eyeball model as described above, the arc length from the leading edge of the break to the center point of the cornea is determined.

[0020] Furthermore, the FCB external pressure position is specifically represented by the arc length from the FCB external pressure position to the limbus of the cornea, and the calculation is specifically: the arc length from the front edge of the hole to the center point of the cornea minus the corneal radius and then minus the preset safety distance to obtain the arc length from the FCB external pressure position to the limbus of the cornea.

[0021] The present invention also provides a computer program product, which includes a computer program, which is executed to implement the method for locating retinal breaks in a three-dimensional eyeball model as described above, or to implement the method for determining the position of FCB external pressure in a three-dimensional eyeball model as described above.

[0022] The method for locating retinal holes in a three-dimensional eyeball model of the present invention relies on step S3 to calculate the arc length from the front edge of the hole to the center point of the cornea in the three-dimensional eyeball model using the chord length obtained from the two-dimensional fundus photograph. In this way, the position of the front edge of the hole can be located in the three-dimensional eyeball model, which is equivalent to locating the front edge of the hole in the patient's diseased eye in three dimensions. Compared with the existing method of positioning through two-dimensional images, it is more accurate.

[0023] The method of determining the FCB external pressure position in a three-dimensional eyeball model of the present invention calculates and determines the FCB external pressure position in the three-dimensional eyeball model according to the arc length from the front edge of the tear to the center point of the cornea, the corneal radius, and the preset safety distance from the front edge of the tear to the root of the FCB drainage tube, and can accurately determine the FCB external pressure position, which is convenient for subsequent doctors to perform surgical treatment on patients. Further, the method uses the above-mentioned retinal tear positioning method to locate the arc length from the front edge of the tear to the center point of the cornea of ​​the patient's diseased eye, that is, to obtain the position of the front edge of the tear, and can accurately locate the position of the front edge of the tear. On this basis, the FCB external pressure position is further calculated to further ensure that the FCB external pressure position can be accurately determined. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 It is a schematic diagram of the cross section of the diseased eye.

[0025] Figure 2 This is a schematic diagram of the relationship between the FCB external pressure position and the retinal tear in the diseased eye.

[0026] Figure 3 Schematic diagram of the process of localizing retinal breaks in a three-dimensional eye model.

[0027] Figure 4 Schematic diagram of a process for determining the location of FCB external pressure in a three-dimensional eyeball model.

[0028] Explanation of the reference numerals in the accompanying drawings: 1. hole; 11. front edge of the hole; 12. rear edge of the hole; 2. macula; 3. sclera; 4. retina; 5. cornea; 51. center point of the cornea; 6. chord length; 7. eye axis; 8. distance between the fixed position of the root of the FCB drainage tube and the limbus of the cornea and sclera; 81. fixed position of the root of the FCB drainage tube (i.e., the position of external pressure application of FCB); 82. limbus of the cornea and sclera; 9. preset safety distance; 100. FCB balloon; 101. FCB drainage tube. DETAILED DESCRIPTION

[0029] The present invention is further described in detail below in conjunction with specific implementation methods.

[0030] Embodiment 1

[0031] This embodiment forms a computer program product through computer code programming, and the computer processor executes the computer program product to implement the following Figure 3 The method for locating retinal holes in a three-dimensional eyeball model is shown in the following. The process of executing the method by a computer is described below.

[0032] S1. Construct a three-dimensional eyeball model based on the axial length of the patient's diseased eye.

[0033] The patient's eye suffers from rhegmatogenous retinal detachment, such as Figure 1 As shown, the retina 4 of the patient's diseased eye is detached to form a tear 1, and surgical treatment is required. The user first uses the existing diseased eye axial length measurement method in the industry, such as ultrasound or optical biometer (Cari Zeiss, IOLMAATER 500) to measure the axial length 7 of the patient's diseased eye, and then inputs the axial length 7 of the patient's diseased eye into the computer. The computer uses 3D reconstruction technology to construct a 3D eyeball model based on the axial length 7 of the patient's diseased eye input by the user.

[0034] S2. Obtain the 2D fundus photograph of the patient's eye from the front edge of the eye hole 11 (see Figure 1 or Figure 2 ) to the fovea 2, the chord length is 6.

[0035] The user uses a fundus camera to take a two-dimensional fundus photo of the patient's diseased eye, and uses an OCT device (optical coherence tomography device) to obtain the actual horizontal diameter of the optic disc of the patient's diseased eye as the reference value S of the horizontal diameter of the optic disc. 基准 . The computer obtains a two-dimensional fundus photograph of the patient's diseased eye from the fundus photography device, and then obtains the true horizontal diameter of the optic disc of the patient's diseased eye from the OCT device. The computer automatically enlarges the two-dimensional fundus photograph of the patient's diseased eye on the display screen, so that the horizontal diameter of the optic disc is enlarged to a preset range value, for example, to 5 to 7 mm. In this embodiment, the horizontal diameter of the optic disc is enlarged to 7 mm, and then in this state, the computer automatically measures the straight-line distance L from the leading edge of the hole 11 in the enlarged fundus photograph to the fovea 2 on the display screen 放大 . Reference value of optic disc horizontal diameter S 基准 Magnification value S of the horizontal diameter of the optic disc 放大 The ratio is equal to the length of the chord from the front edge of the hole 11 to the fovea 2 of the diseased eye 6L 真实 The straight line distance L from the front edge of the hole 11 to the fovea 2 放大 According to this ratio, the length of the chord 6 from the front edge of the hole 11 to the fovea 2 of the diseased eye can be calculated to be L 真实 =L 放大 *S 基准 / S 放大 .

[0036] Preferably, the user can manually magnify the two-dimensional fundus photograph of the patient's diseased eye on the computer or mobile phone display screen, so that the horizontal diameter of the optic disc is magnified to a preset range value, and then use a ruler to manually measure the straight-line distance L from the front edge of the hole 11 in the macular fovea 2 on the display screen in the magnified fundus photograph. 放大 Then, according to the above proportional relationship, the chord length 6 from the front edge of the hole 11 to the fovea 2 of the diseased eye is automatically calculated to be L 真实 =L放大 *S 基准 / S 放大 .

[0037] S3. Based on the chord length 6, the arc length from the front edge of the hole 11 to the center point of the cornea 51 is calculated in the three-dimensional eyeball model.

[0038] The computer draws the chord length 6 in the three-dimensional eyeball model accordingly, and then measures the arc length of the sclera 3 corresponding to the chord length 6 in the three-dimensional eyeball model, and then subtracts the arc length of the sclera 3 from the half arc length of the three-dimensional eyeball model to obtain the arc length from the front edge 11 of the tear to the center point 51 of the cornea. In this embodiment, the arc length from the front edge 11 of the tear to the center point 51 of the cornea is used to represent the position of the front edge of the tear 1. In this embodiment, the arc length from the front edge of the tear to the center point 51 of the cornea is calculated in the three-dimensional eyeball model based on the chord length obtained from the two-dimensional fundus photograph, so that the position of the front edge of the tear can be located in the three-dimensional eyeball model, which is equivalent to locating the front edge of the tear in the patient's diseased eye in three dimensions, which is more accurate than the method of locating by two-dimensional images in the prior art.

[0039] Embodiment 2

[0040] This embodiment forms a computer program product through computer code programming, and the computer processor executes the computer program product to implement the following Figure 4 The method for determining the external pressure position of FCB (folded top pressure balloon) in the three-dimensional eyeball model is shown below. The process of executing the method by a computer is described below.

[0041] This embodiment further determines the FCB external pressure position based on the first embodiment. Steps S1 to S3 of this embodiment are the same as those of the first embodiment and will not be described in detail. Only the differences of this embodiment are described below.

[0042] After the computer obtains the arc length from the front edge of the tear hole 11 to the center point of the cornea 51 according to the process of the first embodiment, that is, after the position of the front edge of the tear hole 11 is located, the following steps are performed:

[0043] S4. In the three-dimensional eyeball model, the FCB external pressure position 81 is calculated and determined based on the arc length from the front edge of the tear 11 to the corneal center point 51, the corneal radius (Corneal Radius, i.e., the radius of curvature of the cornea 5), ​​and the preset safety distance 9 from the front edge of the tear 11 to the root of the FCB drainage tube 101.

[0044] In this case, the patient's diseased eye was surgically treated by FCB episcleral pressure retinal reattachment. Figure 2As shown, the FCB includes a balloon 100 and a drainage tube 101. During the operation, the doctor needs to implant the folded balloon 100 into the outer wall of the eyeball where the retinal tear 1 is located, and then inject the corresponding substance into the balloon through the drainage tube 101 to make the balloon bulge so that the outer wall of the eyeball is close to the retina 4 detached from the tear. The doctor needs to determine the FCB external pressure position (i.e., the FCB implantation position) before the operation, and then perform the operation according to the determined FCB external pressure position. In this example, the FCB external pressure position 81 is specifically represented by the arc length 8 from the FCB external pressure position to the corneal limbus 82. The computer specifically uses the arc length from the front edge of the tear 11 to the corneal center point 51 minus the corneal radius and then minus the preset safety distance 9 to obtain the arc length 8 from the FCB external pressure position 81 to the corneal limbus 82. The preset safety distance 9 from the front edge of the tear 11 to the root of the FCB drainage tube 101 is obtained according to the FCB product size characteristics and clinical experimental data. In this example, the preset safety distance is 4mm. The preset safety distance 9 is the straight-line distance from the leading edge of the tear 11 to the root of the FCB drainage tube 101. Strictly speaking, the arc length from the leading edge of the tear 11 to the corneal center point 51 minus the corneal radius minus the arc length of the sclera 3 corresponding to the preset safety distance 9 should be used to obtain the arc length 8 from the FCB external pressure position 81 to the corneal limbus 82. In this embodiment, considering that the preset safety distance 9 is relatively short and the corresponding arc length of the sclera 3 is approximately 4 mm, the value of the preset safety distance 9 is directly taken as the corresponding arc length of the sclera 3, that is, the arc length from the leading edge of the tear 11 to the corneal center point 51 minus the corneal radius minus the preset safety distance 9 to obtain the arc length 8 from the FCB external pressure position 81 to the corneal limbus 82. In this way, the FCB external pressure position 81 is calculated and determined.

[0045] The above is only an implementation method of the invention, and does not limit the scope of patent protection. Those skilled in the art can make non-substantial changes or substitutions based on the invention, which still fall within the scope of patent protection.

Claims

1. A method for locating retinal breaks in a three-dimensional eyeball model. Its characteristics are: The following steps are involved: S1. Construct a three-dimensional eyeball model based on the axial length of the patient's diseased eye; S2. Obtain the chord length (6) from the front edge of the retinal hole (11) to the fovea (2) of the diseased eye from the two-dimensional fundus photograph of the diseased eye of the patient; S3. Based on the above chord length (6), the arc length from the front edge of the hole (11) to the center point of the cornea (51) is calculated in the three-dimensional eyeball model.

2. The method for locating retinal breaks in a three-dimensional eyeball model as claimed in claim 1, Its characteristics are: Step S1 specifically uses three-dimensional reconstruction technology to construct a three-dimensional eyeball model.

3. The method for locating retinal breaks in a three-dimensional eyeball model as claimed in claim 1, Its characteristics are: Step S2 includes: S21, obtaining the horizontal diameter of the optic disc of the patient's diseased eye as a reference value of the horizontal diameter of the optic disc; S22. Enlarge the fundus photograph of the patient's diseased eye, and convert the straight-line distance from the leading edge of the hole (11) to the fovea maculae (2) in the fundus photograph of the diseased eye to obtain the above-mentioned chord length (6) based on the ratio of the horizontal diameter of the optic disc in the enlarged fundus photograph to the baseline value of the horizontal diameter of the optic disc in the patient's diseased eye.

4. The method for locating retinal breaks in a three-dimensional eyeball model as claimed in claim 3, Its characteristics are: In step S21, an optical coherence tomography device is used to obtain the horizontal diameter of the optic disc of the patient's diseased eye.

5. The method for locating retinal breaks in a three-dimensional eyeball model as claimed in claim 1, Its characteristics are: Step S3 includes: S31. In the three-dimensional eyeball model, measuring the scleral arc length corresponding to the chord length (6); S32. In the three-dimensional eyeball model, the arc length from the front edge of the hole (11) to the center point of the cornea (51) is calculated based on the above-mentioned scleral arc length.

6. The method for locating retinal breaks in a three-dimensional eyeball model as claimed in claim 5, Its characteristics are: Specifically, in step S32, the arc length from the front edge of the hole (11) to the center point of the cornea (51) is obtained by subtracting the arc length of the sclera from the semi-arc length of the three-dimensional eyeball model.

7. A method for determining the location of FCB external pressure in a three-dimensional eyeball model, Its characteristics are: A three-dimensional eyeball model is constructed according to the axial length of the patient's diseased eye. In the three-dimensional eyeball model, the FCB external pressure position is calculated and determined according to the arc length from the front edge of the tear to the center point of the cornea, the corneal radius, and the preset safety distance from the front edge of the tear to the root of the FCB drainage tube (101).

8. The method for determining the FCB external pressure position in a three-dimensional eyeball model as claimed in claim 7, Its characteristics are: According to the method for locating retinal holes in a three-dimensional eyeball model as claimed in any one of claims 1 to 6, the arc length from the leading edge of the hole to the center point of the cornea is determined.

9. The method for determining the FCB external pressure position in a three-dimensional eyeball model as claimed in claim 7, Its characteristics are: The FCB external pressure position (81) is specifically represented by the arc length (8) from the FCB external pressure position to the corneal scleral edge (82), and the calculation is specifically: the arc length from the front edge of the hole (11) to the corneal center point (51) minus the corneal radius and then minus the preset safety distance (9) to obtain the arc length (8) from the FCB external pressure position (81) to the corneal scleral edge (82).

10. A computer program product comprising a computer program, Its characteristics are: The computer program is executed to implement the method for locating retinal breaks in a three-dimensional eyeball model as described in any one of claims 1 to 6, or to implement the method for determining the position of FCB external pressure in a three-dimensional eyeball model as described in any one of claims 7 to 9.

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