Three-phase transdermal diffusion device for simulating pollutants to enter human body through skin

Abstract

The invention relates to a three-phase transdermal diffusion device for simulating pollutants to enter a human body through skin, which comprises a skin equivalent for simulating skin tissues of the human body; the circulation system is used for simulating a human body blood circulation process; the supply chamber is used for supplying pollutants of preset types; the sealing cover is matched with the top of the supply chamber; the positioner is connected with the supply chamber in a matched mode, the positioner is of a downward-protruding structure, and the skin equivalent is jacked up by the positioner so that the skin equivalent can be kept in a tight state; and the receiving pool is used for receiving substances passing through the skin equivalent and entering the circulating system. By arranging the three-phase transdermal diffusion device for simulating pollutants to enter the human body through the skin, the amount of drugs penetrating through the skin can be analyzed for solid, liquid and gas objects, so that the conditions of various pollutant types, the amount of the pollutants penetrating through the skin and the like in various skin tightening states can be explored; and the experiment accuracy is improved.

Description

Technical Field

[0001] The invention relates to a simulation device, in particular to a three-phase transdermal diffusion device for simulating pollutants entering a human body through the skin. Background Art

[0002] There are three ways for pollutants to enter the human body: oral, respiratory and skin contact. However, compared with the first two contact routes, the way pollutants enter the human body through skin contact is often underestimated and ignored. Most of the devices currently used to study the percutaneous absorption of pollutants use transdermal diffusion cells, transdermal diffusion instruments, etc., and the core transdermal diffusion cells in these devices mostly use Franz diffusion cells and improved Franz diffusion cells. The experimental method is to clamp the skin to be tested in the diffusion cell, and then place the diffusion cell in the transdermal diffusion device. By heating the diffusion cell, the drug to be tested on the upper side of the skin passes through the skin of the diffusion cell and infiltrates into the receiving liquid on the lower side of the skin. The concentration in the receiving liquid is tested by regular extraction, the amount of drug passing through the skin is analyzed, and the experimental data is recorded. Finally, the average data is obtained after multiple evaluations.

[0003] Most of the existing transdermal diffusion cells are designed for drugs and reagents, so the research objects are mostly liquids and solids, and there is a lack of research on gas objects; secondly, multiple sampling and fluid replenishment operations are required during the experiment, which will lead to inconsistent concentrations of the receiving liquid before and after, which will have a certain impact on the accuracy of the experiment. Summary of the invention

[0004] The present invention overcomes the shortcomings of the prior art and provides a three-phase transdermal diffusion device for simulating pollutants entering the human body through the skin.

[0005] To achieve the above object, the technical solution adopted by the present invention is:

[0006] The first aspect of the present invention provides a three-phase transdermal diffusion device for simulating the entry of pollutants into the human body through the skin, comprising:

[0007] Skin equivalents, used to simulate human skin tissue;

[0008] Circulatory system, used to simulate the blood circulation process of the human body;

[0009] a supply chamber, for supplying a preset type of pollutant;

[0010] a sealing cover cooperating with the top of the supply chamber;

[0011] A positioner connected to the supply chamber, the positioner being a downward convex structure, and the positioner lifts up the skin equivalent so that the skin equivalent remains in a taut state;

[0012] A receiving reservoir is provided for receiving substances passing through the skin equivalent and entering the circulatory system.

[0013] Furthermore, in the three-phase transdermal diffusion device for simulating the entry of pollutants into the human body through the skin, the bottom of the positioner is also connected to a fixing plate, and the fixing plate is a hollow structure, and the positioner is placed in the hollow structure.

[0014] Furthermore, in the three-phase transdermal diffusion device for simulating the entry of pollutants into the human body through the skin, the fixing sheet is pressed and fixed to the fixator, and is pressed and fixed to the skin equivalent through the fixing sheet.

[0015] Furthermore, in the three-phase transdermal diffusion device for simulating the entry of pollutants into the human body through the skin, vents are provided on both sides of the supply chamber, and air ducts are connected to the vents.

[0016] Furthermore, in the three-phase transdermal diffusion device for simulating the entry of pollutants into the human body through the skin, the circulation system includes a receiving liquid storage tank and a peristaltic pump. Through the action of the peristaltic pump, the receiving liquid in the receiving liquid storage tank flows at a preset flow rate, and the receiving liquid flows through the receiving pool, and the liquid surface is tightly fitted with the lower end of the skin equivalent.

[0017] Furthermore, in the three-phase transdermal diffusion device for simulating the entry of pollutants into the human body through the skin, the three-phase transdermal diffusion device also includes a sampling pool and a fixing device, the sampling pool is connected to the circulation system, and the fixing device is equipped with an extraction needle and an adjustment fixing device.

[0018] Furthermore, in the three-phase transdermal diffusion device for simulating the entry of pollutants into the human body through the skin, the lower convex structure includes a first convex body and a second convex body, at least two groups of telescopic rods are provided on the first convex body, and an elastic protrusion is provided on one end of the telescopic rod, and the elastic protrusion is cooperated and connected with the groove in the second convex body.

[0019] A second aspect of the present invention provides a data analysis method for a three-phase transdermal diffusion device for simulating the entry of pollutants into a human body through the skin, which is applied to any of the three-phase transdermal diffusion devices for simulating the entry of pollutants into a human body through the skin, and comprises the following steps:

[0020] The three-phase transdermal diffusion device is used to simulate the pollutants entering the human body through the skin to obtain the permeation amount data information of each pollutant information under each tension state, and the pollutant permeation amount data prediction model is constructed according to the permeation amount data information of each pollutant information under each tension state;

[0021] Obtaining pollutant types and pollutant concentration information in the target area, and inputting the pollutant types and pollutant concentration information in the target area into the pollutant permeation data prediction model to obtain permeation data information of each pollutant type in the target area under each tension state;

[0022] Preset a permeation data threshold, and identify abnormal target areas and candidate target areas according to the permeation data information of each pollutant type in the target area under each tension state and the permeation data threshold, and trace the pollutants in the abnormal target area;

[0023] The permeation data information of each pollutant type in the candidate target area is obtained, and relevant planning information is generated according to the permeation data information of each pollutant type in the candidate target area, and the relevant planning information is pushed according to a preset method.

[0024] Furthermore, in the data analysis method of the three-phase transdermal diffusion device simulating the pollutants entering the human body through the skin, a pollutant permeation amount data prediction model is constructed according to the permeation amount data information of each pollutant information under each tension state, specifically including:

[0025] Constructing a graph neural network, and inputting the permeation data information of each pollutant information under each tension state into the graph neural network, using the tension state as the first graph node of the graph neural network, using the pollutant information as the second graph node of the graph neural network, and using the permeation data as the third graph node of the graph neural network;

[0026] Constructing a directed edge connection relationship, and constructing a topological structure graph of the first graph node, the second graph node, and the third graph node according to the directed edge connection relationship, obtaining a plurality of topological structure graphs, and introducing a Chebyshev distance metric algorithm to calculate the Chebyshev distance between the second graph nodes in the topological structure graph;

[0027] Obtain a topological structure graph corresponding to a second graph node whose Chebyshev distance is not greater than a preset Chebyshev distance threshold, associate and expand the second graph node to generate an expanded second graph node, and update the topological structure graph according to the expanded second graph node to obtain an updated topological structure graph;

[0028] A pollutant permeability data prediction model is constructed based on a deep neural network, and the updated topological structure diagram is input into the pollutant permeability data prediction model for encoding learning. When the loss function of the pollutant permeability data prediction model converges to a preset value, the pollutant permeability data prediction model is output.

[0029] Furthermore, in the data analysis method of the three-phase transdermal diffusion device for simulating pollutants entering the human body through the skin, the relevant planning information is generated according to the permeation data information of each pollutant type in the candidate target area, specifically including:

[0030] Constructing a big data network, obtaining skin tightness information of each age group through the big data network, and obtaining permeation data information of each pollutant type in each age group in the target area according to the skin tightness information of each age group and the permeation data information of each pollutant type in the candidate target area;

[0031] When the permeation data information of each pollutant type in the target area for one of the age groups is greater than the permeation data threshold, the corresponding age group is used as the warning age group in the target area;

[0032] When the permeation data information of each pollutant type in the target area for one of the age groups is not greater than the permeation data threshold, the corresponding age group is regarded as the normal age group in the target area;

[0033] When there is data of the warning age group in the target area, the corresponding target area is set as the warning area. When there is no data of the warning age group in the target area, the corresponding target area is set as the normal activity area, and relevant planning information is generated based on the warning area and the normal activity area.

[0034] The present invention solves the defects existing in the background technology and has the following beneficial effects:

[0035] The present invention can analyze the amount of drugs that penetrate the skin of solid, liquid, and gas objects by setting up a three-phase transdermal diffusion device that simulates pollutants entering the human body through the skin, thereby being able to explore the types of pollutants, the concentration of pollutants, the amount of pollutants that penetrate the skin under various skin tension states, and other conditions, thereby improving the accuracy of the experiment. On the other hand, the present device is provided with a circulation system, through which multiple sampling can be performed, thereby performing multiple analyses on the sampled data, thereby improving the accuracy of the experiment. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, drawings of other embodiments can be obtained based on these drawings without paying creative work.

[0037] Figure 1 The overall structural schematic diagram of the transdermal diffusion device is shown;

[0038] Figure 2 A schematic diagram of the cross-sectional structure of the positioner is shown;

[0039] Figure 3 A schematic diagram of the three-dimensional structure of the positioner is shown.

[0040] In the figure:

[0041] 1-receiving pool, 2-fixing seat, 3-skin equivalent, 4-fixing plate, 5-locator, 6-supply chamber, 7-vent, 8-sealing cover, 9-sampling pool, 10-extraction needle, 11-fixing device, 12-receiving liquid storage tank, 13-peristaltic pump, 501-first convex body, 502-second convex body, 503-telescopic rod, 504-elastic protrusion, 5021-groove. DETAILED DESCRIPTION

[0042] In order to more clearly understand the above-mentioned purposes, features and advantages of the present invention, the present invention is further described in detail below in conjunction with the accompanying drawings and specific implementation methods. These drawings are all simplified schematic diagrams, which only illustrate the basic structure of the present invention in a schematic manner, and therefore only show the structures related to the present invention. It should be noted that the embodiments in this application and the features in the embodiments can be combined with each other without conflict.

[0043] In the description of the present application, it should be understood that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the scope of protection of the present application. In addition, the terms "first", "second", etc. are only used for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, features defined as "first", "second", etc. may explicitly or implicitly include one or more of the features. In the description of the invention, unless otherwise specified, "multiple" means two or more.

[0044] In the description of this application, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood by specific circumstances.

[0045] In order to facilitate the understanding of the present invention, the present invention will be described more fully below with reference to the relevant drawings. The preferred embodiments of the present invention are given in the drawings. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present invention more thoroughly understood.

[0046] Combination Figure 1 As shown, the transdermal diffusion device includes a receiving pool 1, a fixing seat 2, a skin equivalent 3, a fixing plate 4, a positioner 5, and a supply chamber 6. Vents 7 that can be connected to an airway are opened on both sides of the supply chamber 6, and a sealing cover 8 is used to ensure good sealing of the device during ventilation. If the donor is a liquid, the sealing cover 8 is removed and the vent 7 is blocked to prevent the liquid from seeping out, and the donor can enter from the top of the donor chamber. If the donor is a solid, such as an ointment, the donor can be directly applied to the skin equivalent 3.

[0047] The fixing plate 4 is a hollow structure, in the middle of which a positioner 5 can be placed. The positioner 5 is designed as a downward convex structure, which can lift up the skin equivalent 3 to keep it taut. The fixing plate 4 is pressed and fixed to the fixing seat 2 above the receiving pool, thereby fixing the skin equivalent 3.

[0048] The receiving liquid flows out of the receiving liquid storage tank 12 and flows at a certain flow rate through the peristaltic pump 13, which is equivalent to connecting the corresponding components through the pipeline. The receiving liquid flows through the receiving pool 1, the liquid surface is closely attached to the bottom of the skin equivalent 3, flows through the sampling pool 9 and finally flows back to the receiving liquid storage tank 12, forming a cycle, thereby simulating the blood circulation process of the human body.

[0049] During sampling, the sampler equipped with the extraction needle 10 is fixed by the fixing device 11, and the height of the fixing device 11 is adjusted to make the extraction needle 10 move up and down for extraction sampling, thereby calculating the penetration data information of different pollution types and concentrations of gas, liquid, solid, etc. that penetrate the skin equivalent into the receiving liquid.

[0050] The structure of the locator is as follows: Figure 2 as well as Figure 3As shown, the lower convex structure includes a first convex body 501 and a second convex body 502, at least two groups of telescopic rods 503 are arranged on the first convex body 501, and an elastic protrusion 504 is arranged on one end of the telescopic rod 503, wherein the elastic protrusion 504 is matched and connected with the groove 5021 in the second convex body 502.

[0051] It should be noted that the elastic protrusion 504 is driven by the telescopic rod 503 so that the elastic protrusion 504 is matched and connected with the groove 5021 in the second convex body 502, thereby adjusting the tightness of the skin equivalent 3, thereby measuring the tightness of the skin in different age groups and improving the accuracy of the experiment. The elastic protrusion 504 is set to an elastic material, such as rubber.

[0052] It should be noted that the present invention can analyze the amount of drugs that penetrate the skin of solid, liquid, and gas objects by setting up a three-phase transdermal diffusion device that simulates pollutants entering the human body through the skin, thereby being able to explore the types of pollutants and the amount of pollutant concentration information that penetrate the skin under various skin tension states, thereby improving the accuracy of the experiment. On the other hand, the present device is provided with a circulation system, through which multiple sampling can be performed, thereby performing multiple analyses on the sampled data, thereby improving the accuracy of the experiment.

[0053] A second aspect of the present invention provides a data analysis method for a three-phase transdermal diffusion device for simulating the entry of pollutants into a human body through the skin, which is applied to any of the three-phase transdermal diffusion devices for simulating the entry of pollutants into a human body through the skin, and comprises the following steps:

[0054] S102: obtaining the permeation amount data information of each pollutant information under each tension state by simulating the three-phase transdermal diffusion device for pollutants to enter the human body through the skin, and constructing a pollutant permeation amount data prediction model according to the permeation amount data information of each pollutant information under each tension state;

[0055] S104: obtaining pollutant types and pollutant concentration information in the target area, and inputting the pollutant types and pollutant concentration information in the target area into the pollutant permeation amount data prediction model to obtain permeation amount data information of each pollutant type in the target area under each tension state;

[0056] S106: Preset a permeation data threshold, and identify abnormal target areas and candidate target areas according to the permeation data information of each pollutant type in the target area under each tension state and the permeation data threshold, and trace the pollutants in the abnormal target area;

[0057] It should be noted that when the permeation data information of each pollutant type in the target area under each tension state is greater than the permeation data threshold, it is an abnormal target area, otherwise it is a candidate target area.

[0058] S108: Obtaining the permeation data information of each pollutant type in the candidate target area, generating relevant planning information according to the permeation data information of each pollutant type in the candidate target area, and pushing the relevant planning information in a preset manner.

[0059] It should be noted that in this embodiment, since the skin tightness (firmness) of users in different age groups is inconsistent, this method can accurately predict the permeation data information of each pollutant type in different age groups, so as to select the optimal activity area. The pollution information includes the pollution type and the pollution concentration corresponding to the pollution type.

[0060] Furthermore, in the data analysis method of the three-phase transdermal diffusion device simulating the pollutants entering the human body through the skin, a pollutant permeation amount data prediction model is constructed according to the permeation amount data information of each pollutant information under each tension state, specifically including:

[0061] S202: constructing a graph neural network, and inputting the permeation data information of each pollutant information under each tension state into the graph neural network, using the tension state as the first graph node of the graph neural network, using the pollutant information as the second graph node of the graph neural network, and using the permeation data as the third graph node of the graph neural network;

[0062] S204: constructing a directed edge connection relationship, and constructing a topological structure graph of the first graph node, the second graph node, and the third graph node according to the directed edge connection relationship, obtaining a plurality of topological structure graphs, and introducing a Chebyshev distance metric algorithm to calculate the Chebyshev distance between the second graph nodes in the topological structure graph;

[0063] S206: Obtain the topological structure graph corresponding to the second graph node whose Chebyshev distance is not greater than the preset Chebyshev distance threshold, associate and expand the second graph node to generate an expanded second graph node, and update the topological structure graph according to the expanded second graph node to obtain an updated topological structure graph;

[0064] S208: Construct a pollutant permeability data prediction model based on a deep neural network, input the updated topological structure diagram into the pollutant permeability data prediction model for encoding learning, and output the pollutant permeability data prediction model when the loss function of the pollutant permeability data prediction model converges to a preset value.

[0065] It should be noted that since there are many descriptions of chemicals, such as sodium hydroxide, also known as caustic soda, and sodium carbonate, also known as soda, the system does not know the relationship between sodium carbonate and soda. The Chebyshev distance between the two can be calculated through the Chebyshev distance measurement algorithm. When the Chebyshev distance is not greater than the preset Chebyshev distance threshold, it means that there is a certain relationship between the two. Then the second graph node is associated and expanded, thereby optimizing the topological structure diagram, which not only reduces the number of training in the data set, but also improves the recognition accuracy of the pollutant penetration data.

[0066] Furthermore, in the data analysis method of the three-phase transdermal diffusion device for simulating pollutants entering the human body through the skin, the relevant planning information is generated according to the permeation data information of each pollutant type in the candidate target area, specifically including:

[0067] Constructing a big data network, obtaining skin tightness information of each age group through the big data network, and obtaining permeation data information of each pollutant type in each age group in the target area according to the skin tightness information of each age group and the permeation data information of each pollutant type in the candidate target area;

[0068] When the permeation data information of each pollutant type in the target area for one of the age groups is greater than the permeation data threshold, the corresponding age group is used as the warning age group in the target area;

[0069] When the permeation data information of each pollutant type in the target area for one of the age groups is not greater than the permeation data threshold, the corresponding age group is regarded as the normal age group in the target area;

[0070] When there is data of the warning age group in the target area, the corresponding target area is set as the warning area. When there is no data of the warning age group in the target area, the corresponding target area is set as the normal activity area, and relevant planning information is generated based on the warning area and the normal activity area.

[0071] It should be noted that since the skin firmness (tightness) of users of different age groups is inconsistent, this method can warn relevant age groups where there is harm in the target area, thereby ensuring the health of users.

[0072] In addition, the method may further comprise the following steps:

[0073] Building a local area network in the target area, receiving basic information of users through intelligent terminals, transmitting the basic information of users to the local area network, and obtaining basic information of users in each target area through the local area network;

[0074] Obtaining disease data information of users within a preset time according to basic information of users in the target area, and performing a search through big data according to the disease data information of the users within the preset time to obtain pollution information associated with the disease data information;

[0075] Acquire pollution information in the target area, calculate the Euclidean distance value between the pollution information associated with the disease data information and the pollution information in the target area, and determine whether the Euclidean distance value is greater than a preset Euclidean distance value;

[0076] When the Euclidean distance value is greater than a preset Euclidean distance value, the corresponding target area is marked as a dangerous area, warning information is generated, the warning information is sent to the smart terminal, and related planning information is optimized.

[0077] It should be noted that smart terminals include smart phones, smart watches, etc. Since the relevant pollution types are closely related to the user's diseases, such as a certain skin disease causes the user's skin firmness to decrease, which causes the relevant pollution types to enter the skin tissue more rapidly. This method can further optimize the normal activity area and further protect the user's health.

[0078] In addition, the method may further comprise the following steps:

[0079] Acquire meteorological characteristic data information in the target area and regional location information of the current polluted air type, and construct a pollution spatial distribution map according to the regional location information of the current polluted air type;

[0080] Extracting wind direction characteristic data information according to the meteorological characteristic data information in the target area, and predicting the direction of the pollution spatial distribution map within a preset time based on the wind direction characteristic data information,

[0081] Through prediction, obtain the updated pollution spatial distribution map within the preset time, obtain the warning area and the normal activity area in the target area, and calculate the permeation data information of each pollutant type in each age group corresponding to the pollution information in the pollution spatial distribution map updated within the preset time;

[0082] The warning area and the normal activity area in the target area are updated according to the permeation data information of each pollutant type in each age group corresponding to the pollution information in the pollution spatial distribution map updated within the preset time.

[0083] It should be noted that since the regional location of polluted air types is not fixed and is easily affected by wind direction, this method can further optimize the warning area and normal activity area to further protect the health of users.

[0084] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

[0085] The above is based on the ideal embodiment of the present invention. Through the above description, relevant personnel can make various changes and modifications without departing from the technical concept of the present invention. The technical scope of the present invention is not limited to the content in the specification, and the technology must be determined according to the scope of the claims.

Claims

1. A three-phase transdermal diffusion device for simulating the entry of pollutants into the human body through the skin, characterized in that: include: Skin equivalents, used to simulate human skin tissue; Circulatory system, used to simulate the blood circulation process of the human body; a supply chamber, for supplying a preset type of pollutant; a sealing cover cooperating with the top of the supply chamber; A positioner connected to the supply chamber, the positioner being a downward convex structure, and the positioner lifts up the skin equivalent so that the skin equivalent remains in a taut state; A receiving reservoir is provided for receiving substances passing through the skin equivalent and entering the circulatory system.

2. A three-phase transdermal diffusion device for simulating pollutants entering the human body through the skin according to claim 1, characterized in that: The lower part of the positioner is also connected to a fixing plate, and the fixing plate is a hollow structure, and the positioner is placed in the hollow structure.

3. A three-phase transdermal diffusion device for simulating pollutants entering the human body through the skin according to claim 2, characterized in that: The fixing sheet is pressed and fixed with the fixator, and is pressed and fixed with the skin equivalent through the fixing sheet.

4. A three-phase transdermal diffusion device for simulating pollutants entering the human body through the skin according to claim 1, characterized in that: Ventilation holes are provided on both sides of the supply chamber, and air guide pipes are connected to the vents.

5. A three-phase transdermal diffusion device for simulating pollutants entering the human body through the skin according to claim 1, characterized in that: The circulation system includes a receiving liquid storage tank and a peristaltic pump. Through the action of the peristaltic pump, the receiving liquid in the receiving liquid storage tank flows at a preset flow rate. The receiving liquid flows through the receiving pool, and the liquid surface is closely attached to the lower end of the skin equivalent.

6. A three-phase transdermal diffusion device for simulating pollutants entering the human body through the skin according to claim 1, characterized in that: The three-phase transdermal diffusion device also includes a sampling pool and a fixing device. The sampling pool is connected to the circulation system, and an extraction needle and an adjusting fixing device are installed on the fixing device.

7. A three-phase transdermal diffusion device for simulating pollutants entering the human body through the skin according to claim 1, characterized in that: The lower convex structure includes a first convex body and a second convex body, the first convex body is provided with at least two groups of telescopic rods, one end of the telescopic rod is provided with an elastic protrusion, and the elastic protrusion is matched and connected with a groove in the second convex body.

8. A data analysis method for a three-phase transdermal diffusion device simulating the entry of pollutants into the human body through the skin, characterized in that: The three-phase transdermal diffusion device for simulating pollutants entering the human body through the skin as described in any one of claims 1 to 7 comprises the following steps: The three-phase transdermal diffusion device is used to simulate the pollutants entering the human body through the skin to obtain the permeation amount data information of each pollutant information under each tension state, and the pollutant permeation amount data prediction model is constructed according to the permeation amount data information of each pollutant information under each tension state; Obtaining pollutant types and pollutant concentration information in the target area, and inputting the pollutant types and pollutant concentration information in the target area into the pollutant permeation data prediction model to obtain permeation data information of each pollutant type in the target area under each tension state; Preset a permeation data threshold, and identify abnormal target areas and candidate target areas according to the permeation data information of each pollutant type in the target area under each tension state and the permeation data threshold, and trace the pollutants in the abnormal target area; The permeation data information of each pollutant type in the candidate target area is obtained, and relevant planning information is generated according to the permeation data information of each pollutant type in the candidate target area, and the relevant planning information is pushed according to a preset method.

9. The data analysis method of a three-phase transdermal diffusion device for simulating the entry of pollutants into the human body through the skin according to claim 8, characterized in that: Constructing a pollutant permeation data prediction model based on the permeation data information of each pollutant information under each tension state specifically includes: Constructing a graph neural network, and inputting the permeation data information of each pollutant information under each tension state into the graph neural network, using the tension state as the first graph node of the graph neural network, using the pollutant information as the second graph node of the graph neural network, and using the permeation data as the third graph node of the graph neural network; Constructing a directed edge connection relationship, and constructing a topological structure graph of the first graph node, the second graph node, and the third graph node according to the directed edge connection relationship, obtaining a plurality of topological structure graphs, and introducing a Chebyshev distance metric algorithm to calculate the Chebyshev distance between the second graph nodes in the topological structure graph; Obtain a topological structure graph corresponding to a second graph node whose Chebyshev distance is not greater than a preset Chebyshev distance threshold, associate and expand the second graph node to generate an expanded second graph node, and update the topological structure graph according to the expanded second graph node to obtain an updated topological structure graph; A pollutant permeability data prediction model is constructed based on a deep neural network, and the updated topological structure diagram is input into the pollutant permeability data prediction model for encoding learning. When the loss function of the pollutant permeability data prediction model converges to a preset value, the pollutant permeability data prediction model is output.

10. The data analysis method of a three-phase transdermal diffusion device for simulating the entry of pollutants into the human body through the skin according to claim 8, characterized in that: Generate relevant planning information according to the permeation data information of each pollutant type in the candidate target area, specifically including: Constructing a big data network, obtaining skin tightness information of each age group through the big data network, and obtaining permeation data information of each pollutant type in each age group in the target area according to the skin tightness information of each age group and the permeation data information of each pollutant type in the candidate target area; When the permeation data information of each pollutant type in the target area for one of the age groups is greater than the permeation data threshold, the corresponding age group is used as the warning age group in the target area; When the permeation data information of each pollutant type in the target area for one of the age groups is not greater than the permeation data threshold, the corresponding age group is regarded as the normal age group in the target area; When there is data of the warning age group in the target area, the corresponding target area is set as the warning area. When there is no data of the warning age group in the target area, the corresponding target area is set as the normal activity area, and relevant planning information is generated based on the warning area and the normal activity area.

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