Preparation method of goserelin microspheres and product thereof

The preparation of goserelin microspheres by co-solvent method solves the problems of pain, bleeding and high production cost of long-acting goserelin injection, and achieves the preparation of goserelin microspheres with high drug loading rate, low particle size and sustained release effect, which are suitable for injection with No. 7 needle.

CN119139240BActive Publication Date: 2026-03-03BEIJING BIOTE PHARM CO LTD
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Patent Information

Application Number
CN202411391047.5
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-10-08
Publication Date
2026-03-03
Estimated Expiration
2044-10-08

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Abstract

The present application relates to a kind of goserelin microspheres preparation method and its product, comprising the following steps: goserelin raw material solution and degradable polymer solution are mixed, obtain oil phase;Surfactant is mixed with water, obtain water phase;Oil phase is mixed in water phase, form emulsion, stirring solidification, obtain goserelin microspheres;Wherein, the solvent of goserelin raw material solution and degradable polymer solution is each independently co-solvent, the co-solvent is obtained by mixing first solvent and second solvent.The preparation method compared to traditional multiple emulsion method operation is simpler, and the goserelin microspheres prepared simultaneously has higher drug loading and smaller particle size, can realize the injection administration of 7 needle, the surface of microsphere is no hole, burst release is low, can realize the uniform distribution of drug in microsphere, and substantially no acetic acid residue.
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Citation Information

Patent Citations

  • Continuous release pharmaceutical compositions

    US5366734A

  • Goserelin slow release microsphere medicine composition

    CN104107434A

  • Preparation method of goserelin acetate sustained-release implant

    CN115778909A