Traditional Chinese medicine composition for treating cough after cold

Abstract

The invention discloses a traditional Chinese medicine composition for treating post-cold cough, and relates to the technical field of traditional Chinese medicine, PIC is characterized by intractable and irritant cough, and the reason that the cough is difficult to cure after some patients are infected is that medicines are not developed to relieve exterior syndrome in time at the beginning of the disease, or heat is prematurely cleared, or medicines for astringing lung and relieving cough are frequently used due to pursuing of temporary verification. The traditional Chinese medicine composition has the functions of mainly treating superficial evil depression, retention of guest evil and lung loss. The invention provides a traditional Chinese medicine composition for treating post-cold cough. The traditional Chinese medicine composition is prepared from the following raw materials: 15g of folium mori, 15g of radix bupleuri, 15g of fried semen armeniacae amarae, 12g of scutellaria baicalensis, 15g of adenophora stricta, 15g of thunberg fritillary bulb, 9g of stiff silkworm, 9g of radix paeoniae alba, 6g of schisandra chinensis, 15g of radix asteris, 9g of flos farfarae, 9g of platycodon grandiflorum and 6g of liquorice. The traditional Chinese medicine composition has a good treatment effect on cough after cold, and can obviously improve the attack frequency and duration of cough symptoms.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition for treating cough after a cold. Background Art

[0002] Post-infectious cough (PIC) refers to the persistent cough after the acute symptoms of respiratory infection disappear. Clinically, it is often manifested as an irritating dry cough or a small amount of white mucus sputum, which lasts for 3 to 8 weeks. There is no obvious abnormality in the chest X-ray examination. This is called PIC. For those with obvious cough symptoms, Western medicine currently mainly focuses on symptomatic treatment. In the case of confirmed post-infectious cough, appropriate use of antitussives, expectorants, antihistamines and bronchodilators can be considered.

[0003] PIC is characterized by stubborn and irritating cough, and belongs to the category of "cough" in traditional Chinese medicine. Through years of clinical experience in the diagnosis and treatment of PIC, the characteristics of PIC and the rules of syndrome treatment are summarized and summarized. It is believed that this disease is caused by exogenous cough, and the main cause is wind evil, often accompanied by dryness evil. The main pathogenesis is that wind and dryness damage the lungs, body fluid damages evil lingering, and qi is unfavorable.

[0004] The reason why some patients have difficulty in recovering from cough after infection is that they did not take medicine to relieve the symptoms in time at the beginning of the disease, or they cleared away heat and purged the body too early, or they frequently used lung-reinforcing and antitussive drugs in pursuit of temporary efficacy, which led to the depression of the external evil, the retention of the external evil, and the loss of the lung's function of regulating the body. Such patients have no obvious sputum or only a small amount of thin sputum when coughing, and often feel dry and itchy throat, which triggers cough. Wind is a yang evil, and excess qi will turn into fire and heat, which will consume the body's body fluids. If the body fluids are damaged, dryness will arise. Therefore, after the external wind evil, it is easy to form a syndrome of wind and dryness. Dry evil attacks the lungs, and qi is blocked by evil. The lung qi fails to spread, and cannot distribute the body fluids to moisten the clear orifices, so the throat is dry and sore, the nose is dry and the lips are dry, the throat is itchy and dry cough without sputum or the sputum is thin and sticky. Therefore, patients with wind-dryness attacking the lungs often feel that there is a foreign body blocking the throat. Summary of the invention

[0005] In view of the above-mentioned problems, the present invention aims to provide a traditional Chinese medicine composition for treating cough after cold, which can treat PIC wind-dryness attacking the lung syndrome, and effectively alleviate the clinical symptoms of PIC patients, improve their quality of life, and is safe and has no side effects, and can be widely used in clinical practice.

[0006] The main idea of ​​the technical solution adopted by the present invention is as follows: Due to the differences in individual health conditions, immunity, eating habits, etc., the pathogenesis of post-infectious cough is complicated. It is not just a simple form of incomplete elimination of the exogenous wind-dryness evil, but usually involves the unfavorable qi mechanism of the internal organs. Patients with post-infectious cough will also have symptoms such as dry mouth, chest and flank fullness, and loss of appetite. This is related to the fact that the external evil enters the interior along the meridians and is depressed in the half-exterior and half-interior part of the Shaoyang, resulting in poor qi mechanism. For this kind of concurrent symptoms, Xiao Chaihu Decoction should be used in combination to use the method of both exterior and interior resolution to regulate the qi mechanism.

[0007] However, it is worth noting that although a large number of researchers have reported on treating PIC from the perspective of wind evil, and some doctors have gained experience in treating PIC with Xiao Chaihu Decoction from practice, no scholar has yet proposed combining these two basic and effective treatment methods. If the treatment is based solely on wind evil, and only dispersing wind and evil, and ignoring the stagnation of internal qi, the more it is dispersed, the weaker the surface defense will be, the stagnation of internal qi will be, and the cough will never be relieved; on the other hand, if Xiao Chaihu Decoction is only used to treat PIC, it is suspected of promoting wind, fire, dryness and heat. Based on the pathological characteristics of wind and dryness damaging the lungs, body fluid damaging evil lingering, and unfavorable qi movement, clinical treatment should focus on dispersing wind and moistening dryness, and harmonizing qi movement.

[0008] Sangchai Decoction is composed of 13 herbs, including mulberry leaves, bupleurum, stir-fried bitter almonds, scutellaria, adenophora, Fritillaria thunbergii, bombyx batryticatus, white peony root, schisandra, aster, coltsfoot flower, platycodon grandiflorum, and liquorice. Mulberry leaves and bupleurum are the main herbs in the prescription. Mulberry leaves are light and ascending, good at running through the lung meridian, and have the functions of dispelling wind and clearing the lungs, moistening dryness and relieving coughs; the polyphenol compounds and polysaccharide compounds contained in mulberry leaves have significant antibacterial, antiviral and anti-inflammatory effects. Bupleurum has the functions of clearing the stagnant fire of the gallbladder meridian, dispersing the blockage of wood qi, and lowering the gallbladder and stomach reverse qi; the saponin components in bupleurum have obvious anti-inflammatory effects, which can significantly inhibit inflammatory exudation, increase capillary permeability, and reduce the release of inflammatory mediators. The combination of mulberry and bupleurum can dispel wind and clear the exterior and reconcile Shaoyang at the same time, and both the exterior and interior are resolved, and they are the main herbs. Apricot kernel and scutellaria are the ministers. Scutellaria clears the interior heat and helps the main herb bupleurum to clear the exterior. Baicalin, as one of the effective flavonoid components in Scutellaria baicalensis extract, has a wide range of pharmacological activities such as anti-inflammatory, antioxidant, and antidepressant. Almonds clear dryness and moisten the lungs, and help the main drug mulberry leaves moisten dryness. The main chemical component of almonds is amygdalin, which can produce trace amounts of hydrocyanic acid and benzaldehyde in the body, which can inhibit the respiratory center, relax bronchial smooth muscles, and make breathing smooth, achieving the effect of relieving cough and asthma. Northern Adenophora nourishes yin and produces body fluid, and Fritillaria thunbergii clears heat and resolves phlegm; Bombyx batryticatus activates collaterals and dredges, dispels wind and relieves sore throat. These three flavors are adjuvants. Aster and coltsfoot flower reduce adverse qi and stop coughing, white peony and Schisandra acid astringe and restrain lung qi, Platycodon grandiflorum and licorice disperse stagnation, rush down to reverse, and treat dry throat, itching and pain. These three groups of medicines are the guiding drugs. Modern pharmacological studies have found that the main chemical components of Adenophora adenophora include polysaccharides, coumarins, polyacetylenes, lignans, phenolic acids, etc., which have multiple pharmacological activities such as immunomodulation, anti-tumor, antioxidant, and anti-inflammatory; Bombyx batryticatus water extract, terpenes and glycosides in Aster tataricus, flavonoids and phenolic acids in Coltsfoot Flos, and Platycodon grandiflorus saponins all have good antitussive functions. This prescription is exquisitely matched, containing the four methods of "promoting", "harmony", "clearing" and "moistening", and can treat both the symptoms and the root causes of the exterior and interior. It can promote and harmonize the qi of the exterior and interior, and can also clear and moisten dryness and heat, and can effectively improve the clinical symptoms of PIC patients. It can be seen that Sangchai Decoction is targeted at PIC wind-dryness attacking the lungs, and the prescription and the syndrome correspond, the drug and the syndrome are relative, and the efficacy is outstanding.

[0009] In order to achieve the above object, the technical solution adopted by the present invention is as follows:

[0010] A traditional Chinese medicine composition for treating cough after cold is prepared from the following raw materials: 15g of mulberry leaf, 15g of bupleurum, 15g of stir-fried bitter almond, 12g of scutellaria, 15g of adenophora, 15g of fritillary bulb, 9g of bombyx batryticatus, 9g of white peony root, 6g of schisandra chinensis, 15g of aster, 9g of coltsfoot flower, 9g of platycodon grandiflorum, and 6g of liquorice.

[0011] A medicine for treating cough after cold, which is a decoction prepared by using the above-mentioned Chinese medicine composition.

[0012] A decoction for treating cough after a cold, the preparation method of the decoction is as follows:

[0013] (1) weighing the drug components according to the above ratios, mixing them, and obtaining a Chinese medicine composition;

[0014] (2) Mix the Chinese medicine composition with water, decoct for 1 to 3 times, combine the decoctions, filter, and obtain the filtrate to obtain a decoction.

[0015] The beneficial effects of the present invention are as follows: the prescription is exquisitely matched, contains the four methods of "promoting", "harmony", "clearing" and "moistening", and treats both the symptoms and the root causes of the exterior and interior. It can promote and harmonize the qi of the exterior and interior, and can clear and moisten the dryness and heat, and can effectively improve the clinical symptoms of PIC patients. It can be seen that Sangchai Decoction is targeted at PIC wind-dryness attacking the lungs, the prescription corresponds to the syndrome, the drug corresponds to the syndrome, and the curative effect is outstanding. Sangchai Decoction is effective in treating PIC wind-dryness attacking the lungs, can effectively alleviate the clinical symptoms of PIC patients, improve their quality of life, and is safe and has no side effects, and is worthy of widespread use in clinical practice. DETAILED DESCRIPTION

[0016] In order to make the purpose, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below in combination with the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments.

[0017] The inventors have found that PIC is characterized by stubborn and irritating coughs, and belongs to the category of "cough" diseases in traditional Chinese medicine. Through many years of clinical experience in distinguishing and treating PIC, the characteristics of PIC onset and the rules of syndrome treatment are summarized and summarized. It is believed that this disease is caused by exogenous cough. The main cause is wind evil, often accompanied by dry evil. The main pathogenesis is that wind and dryness damage the lungs, body fluid damages evil lingers, and qi is unfavorable. The reason why some patients are difficult to recover from cough after infection is that they did not prescribe medicine to relieve the symptoms in time at the beginning of the disease, or cleared heat and purged too early, or blindly pursued temporary efficacy and frequently used lung-reinforcing and antitussive drugs, resulting in the depression of surface evil, the retention of guest evil, and the loss of the function of the lung to treat the main section. Such patients have no obvious sputum or only a small amount of thin sputum when coughing, and often feel dry and itchy throat and cough. Wind is a yang evil. If there is excess qi, it will turn into fire and heat, which will consume the body fluid. If the body fluid is damaged, dryness will arise. Therefore, after the exogenous wind evil, it is easy to form a syndrome of wind and dryness. When the dryness attacks the lungs, the qi is blocked by the evil, and the lung qi fails to spread, and cannot distribute the body fluid to moisten the clear orifices, so the throat becomes dry and painful, the nose becomes dry and the lips become dry, the throat becomes itchy, and the cough is dry without sputum or with thin and sticky sputum. Therefore, patients with wind-dryness attacking the lungs often feel a foreign body blocking the throat.

[0018] Based on the above findings, the present application proposes a Chinese medicine composition for treating cough after a cold, and Sangchai Decoction is composed of 13 herbs, including mulberry leaves, bupleurum, stir-fried bitter almonds, scutellaria, adenophora, Fritillaria thunbergii, bombyx batryticatus, white peony root, schisandra, aster, coltsfoot flower, platycodon grandiflorum, and licorice. Mulberry leaves and bupleurum are the monarchs in the prescription. Mulberry leaves are light and ascending, good at running through the lung meridian, and have the functions of dispelling wind and clearing the lungs, moistening dryness and relieving cough; the polyphenol compounds and polysaccharide compounds contained in mulberry leaves have significant antibacterial, antiviral and anti-inflammatory effects. Bupleurum has the functions of clearing the stagnant fire of the gallbladder meridian, dispersing the blockage of wood qi, and lowering the gallbladder and stomach reverse qi; the saponin components in bupleurum have obvious anti-inflammatory effects, which can significantly inhibit inflammatory exudation, increase capillary permeability, and reduce the release of inflammatory mediators. Mulberry and bupleurum are used together to dispel wind and clear the exterior and reconcile Shaoyang, and both the exterior and interior are solved, and they are the monarch medicines.

[0019] Embodiment 1

[0020] A traditional Chinese medicine composition for treating cough after cold is prepared from the following raw materials: 15g of mulberry leaf, 15g of bupleurum, 15g of stir-fried bitter almond, 12g of scutellaria, 15g of adenophora, 15g of fritillary bulb, 9g of bombyx batryticatus, 9g of white peony root, 6g of schisandra chinensis, 15g of aster, 9g of coltsfoot flower, 9g of platycodon grandiflorum, and 6g of liquorice.

[0021] The Chinese medicine composition can be prepared into a decoction, and the specific preparation method is as follows:

[0022] (1) weighing the drug components according to the above ratios, mixing them, and obtaining a Chinese medicine composition;

[0023] (2) Mix the Chinese medicine composition with water, decoct for 1 to 3 times, combine the decoctions, filter, and obtain the filtrate to obtain a decoction.

[0024] Test Example 1

[0025] 1. Case selection

[0026] A total of 80 outpatients from the Department of Respiratory and Critical Care Medicine of Chongqing Hospital of Traditional Chinese Medicine from May 2023 to October 2023 were selected and randomly divided into two groups: a treatment group and a control group, with 40 people in each group. There were 4 dropouts in the treatment group, and 36 cases were actually completed. Among the patients, there were 15 males and 21 females, with an average age of (43.7±13.8) years old; there were 2 dropouts in the control group, and 38 cases were actually completed. Among the patients, there were 18 males and 20 females, with an average age of (43.1±14.7) years old. The course of the disease was between 3 and 8 weeks, with 3 to 4 weeks being the most common. The data of the two groups were statistically analyzed, and there was no statistically significant difference (P>0.05), which was comparable.

[0027] 2. Method of administration

[0028] Treatment groups 1-7: Using Example 1, boil 3 bags of Chinese medicine for each dose, each bag has 150 ml, take 1 bag each time while warm, orally 0.5-1 hour after meals in the morning, noon and evening.

[0029] Control group 1: Compound methoxyphenamine capsules (approval number: SA124AD, 60 capsules / bottle, Daiichi Sankyo Pharmaceutical Beijing Co., Ltd.), oral, 2 capsules / time, 3 times / day. Both groups were treated for 1 week.

[0030] Both groups were treated continuously for 1 week.

[0031] 3. Diagnostic criteria

[0032] (1) Western medicine diagnostic criteria: refer to the diagnostic criteria for PIC in the 2015 Guidelines for the Diagnosis and Treatment of Cough published by the Chinese Society of Respiratory Medicine.

[0033] (2) Diagnostic criteria of TCM syndromes: refer to the Diagnostic and Efficacy Criteria of TCM Diseases promulgated by the State Administration of Traditional Chinese Medicine, TCM Internal Medicine edited by Zhou Zhongying and published by China Traditional Chinese Medicine Press in 2007, and the Guiding Principles for Clinical Research of New Chinese Medicines.

[0034] 4. Inclusion criteria

[0035] Patients must meet the following four conditions to be included: ① meet the Western medicine diagnostic criteria of PIC; ② meet the Chinese medicine syndrome diagnostic criteria of wind-dryness invading the lungs; ③ age: between 18 and 70 years old.

[0036] 5. Exclusion criteria

[0037] ① Those who do not meet the above-mentioned Western medicine and Chinese medicine diagnostic criteria;

[0038] ② Women who are pregnant, breastfeeding or planning to get pregnant;

[0039] ③Abnormal blood routine test;

[0040] ④ Those with a history of allergy to the drugs used in this study;

[0041] ⑤ Patients with severe heart failure, acute stroke and other cardiovascular and cerebrovascular diseases, as well as severe liver and kidney function damage;

[0042] ⑥ Those with a history of chronic diseases such as pulmonary calcium, chronic obstructive pulmonary disease, tuberculosis, and asthma;

[0043] Those who have any of the above conditions are not allowed to participate in this trial.

[0044] 6. Observation indicators and methods

[0045] (1) Changes in subjective symptom scores: Patients self-assessed the severity of their cough using a visual analogue scale (VAS).

[0046] (2) Changes in cough symptom scores: The patient's daytime and nighttime cough symptom scores were measured and then added together.

[0047] (3) Changes in TCM syndrome scores: Based on the "Guidelines for Clinical Research of New Chinese Medicines" and "Standards for Diagnosis and Efficacy of TCM Diseases and Syndromes", the changes in TCM syndrome scores (main symptoms: cough, dry and itchy throat; secondary symptoms: dry and bitter mouth, sputum, and induced cough) before and after treatment were observed.

[0048] According to the total symptom score before and after treatment, the efficacy index was calculated according to the nimodipine method to determine the efficacy. The clinical efficacy evaluation criteria are as follows: clinical cure refers to the disappearance or basic disappearance of clinical symptoms, and the symptom score efficacy n≥95%; marked effect refers to obvious improvement of clinical symptoms, and the symptom score efficacy is 70%≤n<95%; effective refers to the alleviation of clinical symptoms, and the symptom score efficacy is 30%≤n≤70%; ineffective refers to no obvious improvement of clinical symptoms, or even aggravation, and the symptom score efficacy is n<30%. (Calculate the efficacy according to the nimodipine method, efficacy index (n) = (pre-treatment score - post-treatment score) / pre-treatment score × 100%).

[0049] 7. SPSS24.0 software was used for statistical analysis of the data. The measurement data were tested with t value, and the counting data were tested with x±s test. The difference was considered statistically significant when P < 0.05.

[0050] 8. Results

[0051] (1) Comparison of the overall efficacy between the two groups of patients: The total effective rate of the treatment group was 97.22%, significantly higher than that of the control group (86.84%) (P < 0.05).

[0052] Table 1 Comparison of therapeutic efficacy between the two groups of patients (cases)

[0053]

[0054] (2) Comparison of VAS scores of subjective symptoms between the two groups before and after treatment showed that both groups decreased after treatment, with a statistically significant difference (P < 0.05); and the subjective symptom score in the treatment group was lower than that in the control group, with a statistically significant difference (P < 0.05).

[0055] Table 2 Comparison of VAS scores between the two groups before and after treatment (M (P25-P75), points)

[0056]

[0057]

[0058] Note: *: Compared with before treatment, P < 0.05

[0059] (3) Comparison of cough symptom scores between the two groups before and after treatment: After treatment, the daytime and nighttime cough symptom scores were lower than those before treatment, and the difference was statistically significant (P < 0.05). In addition, the scores of the treatment group were lower than those of the control group, which was statistically significant (P < 0.05).

[0060] Table 3 Comparison of cough symptom scores between the two groups before and after treatment

[0061]

[0062] Note: *: Compared with before treatment, P < 0.05

[0063] (4) Comparison of TCM symptom scores between the two groups before and after treatment: After treatment, the TCM symptom scores of both groups decreased, and the difference was statistically significant (P<0.05). In the treatment group, the scores of cough, dry and itchy throat, dry and bitter mouth, sputum, and induced cough were all lower than those in the control group, and the difference was statistically significant (P<0.05).

[0064] Table 4 Comparison of TCM symptom scores between the two groups before and after treatment

[0065]

[0066]

[0067] (5) Safety observation For the two groups of PIC patients, safety indicators such as blood routine, liver and kidney function, urine routine, stool routine, and electrocardiogram were observed before and after treatment, and no obvious abnormalities were found. During the treatment, 36 patients in the treatment group had no adverse reactions; a total of 5 patients in the control group had mild adverse reactions, including 3 cases of drowsiness, 1 case of stomach discomfort, and 1 case of palpitations, which recovered on their own and did not affect the drug treatment observation.

[0068] PIC is characterized by stubborn and irritating cough, and belongs to the category of "cough" in traditional Chinese medicine. Through years of clinical experience in the diagnosis and treatment of PIC, the characteristics of PIC and the rules of syndrome treatment are summarized and summarized. It is believed that this disease is caused by exogenous cough, and the main cause is wind evil, often accompanied by dryness evil. The main pathogenesis is that wind and dryness damage the lungs, body fluid damages evil lingering, and qi is unfavorable.

[0069] The reason why some patients have difficulty in curing cough after infection is that they did not take medicine to relieve the symptoms in time at the beginning of the disease, or cleared away heat and purged the body too early, or they blindly pursued temporary effects and frequently used lung-reinforcing and antitussive drugs, which led to the depression of the surface evil, the retention of the external evil, and the loss of the lung's function of governing the regulation. Such patients have no obvious sputum or only a small amount of thin sputum when coughing, and often feel dry and itchy throats, which triggers coughs. Wind is a yang evil, and excess qi will turn into fire and heat, which will consume the body's body fluids. If the body fluids are damaged, dryness will arise. Therefore, after the exogenous wind evil, it is easy to form a syndrome of wind and dryness. Dryness evil attacks the lungs, and qi is blocked by evil. The lung qi fails to spread, and cannot spread the body fluids to moisten the clear orifices, so the throat is dry and painful, the nose is dry and the lips are dry, the throat is itchy and dry coughs without sputum or the sputum is thin and sticky. Therefore, patients with wind-dryness attacking the lungs often feel that there is a foreign body blocking the throat. Therefore, it is believed that coughing after infection is caused by wind evil attacking the lungs, the lung qi fails to spread, and the qi is reversed and coughs, and it is easy to be accompanied by dryness evil, which is the key to the pathogenesis of this disease.

[0070] Due to differences in individual health conditions, immunity, eating habits, etc., the pathogenesis of post-infectious cough is complicated. It is not just a simple form of incomplete elimination of exogenous wind-dryness evil, but usually involves unfavorable internal organs qi. Patients with post-infectious cough will also have symptoms such as dry mouth, fullness and stuffiness in the chest and flanks, and loss of appetite. This is related to the external evil entering the interior along the meridians and stagnates in the Shaoyang half-exterior and half-interior area, resulting in poor qi movement. For this type of concurrent symptoms, Xiao Chaihu Decoction should be used in combination to use the method of both exterior and interior resolution to regulate the qi.

[0071] However, it is worth noting that although a large number of researchers have reported on treating PIC from the perspective of wind evil, and some doctors have gained experience in treating PIC with Xiao Chaihu Decoction from practice, no scholar has yet proposed combining these two basic and effective treatment methods. If the treatment is based solely on wind evil, and only dispersing wind and evil, and ignoring the stagnation of internal qi, the more it is dispersed, the weaker the surface defense will be, the stagnation of internal qi will be, and the cough will never be relieved; on the other hand, if Xiao Chaihu Decoction is only used to treat PIC, it is suspected of promoting wind, fire, dryness and heat. Based on the pathological characteristics of wind and dryness damaging the lungs, body fluid damaging evil lingering, and unfavorable qi movement, clinical treatment should focus on dispersing wind and moistening dryness, and harmonizing qi movement.

[0072] Sangchai Decoction is composed of 13 herbs, including mulberry leaves, bupleurum, stir-fried bitter almonds, scutellaria, adenophora, Fritillaria thunbergii, bombyx batryticatus, white peony root, schisandra, aster, coltsfoot flower, platycodon grandiflorum, and liquorice. Mulberry leaves and bupleurum are the main herbs in the prescription. Mulberry leaves are light and ascending, good at running through the lung meridian, and have the functions of dispelling wind and clearing the lungs, moistening dryness and relieving coughs; the polyphenol compounds and polysaccharide compounds contained in mulberry leaves have significant antibacterial, antiviral and anti-inflammatory effects. Bupleurum has the functions of clearing the stagnant fire of the gallbladder meridian, dispersing the blockage of wood qi, and lowering the gallbladder and stomach reverse qi; the saponin components in bupleurum have obvious anti-inflammatory effects, which can significantly inhibit inflammatory exudation, increase capillary permeability, and reduce the release of inflammatory mediators. The combination of mulberry and bupleurum can dispel wind and clear the exterior and reconcile Shaoyang at the same time, and both the exterior and interior are resolved, and they are the main herbs. Apricot kernel and scutellaria are the ministers. Scutellaria clears the interior heat and helps the main herb bupleurum to clear the exterior. Baicalin, as one of the effective flavonoid components in Scutellaria baicalensis extract, has a wide range of pharmacological activities such as anti-inflammatory, antioxidant, and antidepressant. Almonds clear dryness and moisten the lungs, and help the main drug mulberry leaves moisten dryness. The main chemical component of almonds is amygdalin, which can produce trace amounts of hydrocyanic acid and benzaldehyde in the body, which can inhibit the respiratory center, relax bronchial smooth muscles, and make breathing smooth, achieving the effect of relieving cough and asthma. Northern Adenophora nourishes yin and produces body fluid, and Fritillaria thunbergii clears heat and resolves phlegm; Bombyx batryticatus activates collaterals and dredges, dispels wind and relieves sore throat. These three flavors are adjuvants. Aster and coltsfoot flower reduce adverse qi and stop coughing, white peony and Schisandra acid astringe and restrain lung qi, Platycodon grandiflorum and licorice disperse stagnation, rush down to reverse, and treat dry throat, itching and pain. These three groups of medicines are the guiding drugs. Modern pharmacological studies have found that the main chemical components of Adenophora adenophora include polysaccharides, coumarins, polyacetylenes, lignans, phenolic acids, etc., which have multiple pharmacological activities such as immunomodulation, anti-tumor, antioxidant, and anti-inflammatory; Bombyx batryticatus water extract, terpenes and glycosides in Aster tataricus, flavonoids and phenolic acids in Coltsfoot Flos, and Platycodon grandiflorus saponins all have good antitussive functions. This prescription is exquisitely matched, containing the four methods of "promoting", "harmony", "clearing" and "moistening", and can treat both the symptoms and the root causes of the exterior and interior. It can promote and harmonize the qi of the exterior and interior, and can also clear and moisten dryness and heat, and can effectively improve the clinical symptoms of PIC patients. It can be seen that Sangchai Decoction is targeted at PIC wind-dryness attacking the lungs, and the prescription and the syndrome correspond, the drug and the syndrome are relative, and the efficacy is outstanding.

[0073] Through research, it was found that Sangchai Decoction is effective in treating PIC wind-dryness invading the lungs. It can effectively alleviate the clinical symptoms of PIC patients and improve their quality of life. It is safe and has no side effects, and is worthy of widespread use in clinical practice.

[0074] The above shows and describes the basic principles, main features and advantages of the present invention. It should be understood by those skilled in the art that the present invention is not limited to the above embodiments, and the above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention to be protected. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. A Chinese medicine composition for treating cough after cold, characterized in that: It is made from the following raw materials: 15g of mulberry leaves, 15g of bupleurum, 15g of stir-fried bitter almonds, 12g of scutellaria, 15g of adenophora, 15g of fritillary bulb, 9g of bombyx batryticatus, 9g of white peony root, 6g of schisandra chinensis, 15g of aster, 9g of coltsfoot flower, 9g of platycodon grandiflorum, and 6g of licorice.

2. A medicine for treating cough after a cold, characterized in that: The medicine is a decoction prepared using the Chinese medicine composition according to claim 1.

3. A decoction for treating cough after a cold, characterized in that: The preparation method of the decoction is as follows: (1) weighing the drug components according to the ratio described in claim 1, mixing them, and obtaining a Chinese medicine composition; (2) Mix the Chinese medicine composition with water, decoct for 1 to 3 times, combine the decoctions, filter, and obtain the filtrate to obtain a decoction.

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