Formula and preparation method of traditional Chinese medicine compound hydrogel acupoint patch for treating hypertension eye diseases

Abstract

The invention relates to a formula and a preparation method of a traditional Chinese medicine compound hydrogel acupoint patch for treating hypertensive eye diseases, the acupoint patch combines traditional Chinese medicine and modern hydrogel technologies, and aims to relieve symptoms of the hypertensive eye diseases and improve eyesight of patients in an acupoint application mode. The acupoint patch contains various traditional Chinese medicinal materials such as tribulus terrestris, gastrodia elata and eucommia ulmoides, and the traditional Chinese medicinal materials are subjected to special treatment and formula, so that the acupoint patch has the effects of reducing blood pressure, improving eyesight, clearing heat, detoxifying and promoting blood circulation to remove blood stasis. The matrix material of the hydrogel adopts diatomite, glycerin, 1, 2-propylene glycol, sodium polyacrylate and the like, has good adhesion, air permeability and moisture retention, can make the medicine permeate into the deep layer of the skin better, and improves the medicine effect. The preparation method comprises the following steps: drying the medicinal materials, crushing, extracting, concentrating, mixing and the like, and finally forming a hydrogel form which is easy to apply. When the acupoint patch is used, the acupoint patch is attached to key acupoints such as a pension acupoint and a Guming acupoint, and absorption and action of medicine are promoted through slight massage and kneading.

Description

Technical Field

[0001] The invention relates to the technical field of medical and health care, and in particular to a formula and a preparation method of a traditional Chinese medicine compound hydrogel acupoint patch for treating hypertensive eye diseases. Background Art

[0002] According to the data published in the "Blue Book on the Current Status of Hypertension Prevention and Treatment in China 2018" released by the National Health Commission in August 2019, it is predicted that the prevalence of hypertension in China will reach 31.89% in 2019. Hypertension can cause many complications in the eyes and cause serious damage, such as hallucinations, amaurosis, eye edema, conjunctival hemorrhage, vitreous hemorrhage, retinal lesions, etc., and in severe cases, it can also cause permanent blindness.

[0003] Traditional Chinese medicine believes that meridian acupoints are channels for energy flow in the human body. By stimulating specific acupoints, the body's physiological functions can be regulated to achieve the purpose of treating diseases. In recent years, the treatment of diseases by stimulating acupoints has been widely accepted by patients, and the treatment effect is remarkable, such as the famous ear stickers with fenugreek seeds. By reading literature and analyzing data, we found that the current treatment of hypertension on the market mainly involves taking antihypertensive drugs, and the types and quantities of drugs are considerable, but less attention is paid to the eye diseases caused by them. In addition, some patients believe that antihypertensive drugs have great side effects and are unwilling to take them, which leads to more serious eye complications and brings great inconvenience to patients' daily lives. In addition, through actual investigations, it was found that most of the acupoint stickers on the market currently have deficiencies such as tearing and irritation, colloid residue, and stuffy and airtight sensitization.

[0004] In order to solve the above existing problems, the present invention discloses a formula and preparation method of a Chinese medicine compound hydrogel acupoint patch for treating hypertensive eye disease Summary of the invention

[0005] In order to solve the problems of the prior art, the present invention provides a formula and a preparation method of a Chinese medicine compound hydrogel acupoint patch for treating hypertensive eye diseases.

[0006] In order to solve the above technical problems, the present invention is achieved through the following technical scheme: a formula of a Chinese medicine compound hydrogel acupoint patch for treating hypertensive eye disease, characterized in that the formula includes the following Chinese medicinal ingredients: Tribulus terrestris, Gastrodia elata (fried to preserve its properties), Eucommia ulmoides, Chrysanthemum, Buddleja buddleja, Angelica sinensis (soaked in wine, baked to dry), Rehmannia glutinosa (soaked in wine, baked to dry), Chuanxiong, Red Peony Root (soaked in hot water), Bombyx batryticatus (soaked in hot water, washed to remove silk, fried with ginger juice), Periostracum cicadais (soaked in water, washed, head and feet removed), Notopterygium incisum, Saposhnikovia divaricata, Nepeta tenuifolia, Equisetum arvense (removed roots and nodes), Semen Cassiae (burned to preserve its properties), Angelica dahurica, Licorice, Ophiopogon japonicus, Scutellaria baicalensis, Fructus Aurantii Immaturus (fried), Vitex rotundifolia (slightly crushed), Borneolum and Mint;

[0007] The hydrogel matrix material comprises diatomaceous earth, glycerol, 1,2-propylene glycol, sodium polyacrylate, aluminum glycinate, disodium ethylenediaminetetraacetate, tartaric acid, polyvinylpyrrolidone K90 and white mustard.

[0008] In some specific embodiments, the formula of the Chinese medicine compound hydrogel acupoint patch for treating hypertensive eye disease is mixed with the following Chinese medicinal materials: 4.5g of Tribulus terrestris, 3g of Gastrodia elata, 3g of Eucommia ulmoides, 3g of Chrysanthemum, 2.1g of Buddleja buddha, 3g of Angelica sinensis, 3g of Rehmannia glutinosa, 4.5g of Ligusticum chuanxiong, 7.5g of Red Peony Root, 3g of Bombyx batryticatus, 1.8g of Periostracum cicadae, 3g of Notopterygium wilfordii, 3g of Saposhnikovia divaricata, 3g of Nepeta tenuifolia, 3g of Equisetum arvense, 3g of Semen Cassiae, 4.5g of Angelica dahurica, 2.1g of Licorice, 6g of Ophiopogon japonicus, 3g of Scutellaria baicalensis, 3g of Fructus Aurantii Immaturus, 3g of Vitex rotundifolia, 3g of Borneolum, and 200g of Menthus fragrans;

[0009] Hydrogel matrix materials, diatomaceous earth 1.2g, glycerol and 1,2-propylene glycol (2:1) 25g in total, sodium polyacrylate (NP-700) 6g, aluminum glycinate 0.5g, concentrated drug 3ml, pure water, disodium ethylenediaminetetraacetic acid 0.3g, tartaric acid 0.2g, polyvinylpyrrolidone K901.5g, white mustard.

[0010] The Chinese herbal ingredients in this formula have the effects of lowering blood pressure, improving eyesight, clearing away heat, detoxifying, and promoting blood circulation and removing blood stasis, and can effectively improve the symptoms of patients with hypertensive eye diseases.

[0011] A method for preparing a Chinese medicine compound hydrogel acupoint patch for treating hypertensive eye disease, the method comprising the following steps:

[0012] Step 1: treating the Chinese medicinal material components of Tribulus terrestris, Gastrodia elata, Eucommia ulmoides, Chrysanthemum, Buddleja bud, Angelica sinensis, Rehmannia root, Chuanxiong, Red Peony Root, Bombyx batryticatus, Periostracum cicadae, Notopterygium wilfordii, Saposhnikovia divaricata, Nepeta tenuifolia, Equisetum arvense, Semen Cassiae, Angelica dahurica, Licorice, Ophiopogon japonicus, Scutellaria baicalensis, Fructus Aurantii Immaturus, and Fructus Viticis rotundifolia, drying, mixing and grinding to obtain a powder;

[0013] Step 2: Using 70% ethanol as solvent, the drug powder and solvent are 1:10, heated and extracted twice, and the extract is filtered by activated carbon absorption and concentrated by rotary evaporation;

[0014] Step 3: Add borneol until dissolved to obtain a concentrated solution for later use;

[0015] Step 4: extracting peppermint volatile oil from peppermint for later use;

[0016] Step 5: Weigh diatomaceous earth and put it into a beaker, add glycerol and 1,2-propylene glycol, stir evenly, then add sodium polyacrylate (NP-700), aluminum glycinate, 3.0 ml of concentrated drug solution and 0.5 g of peppermint volatile oil, and continue to stir evenly, as phase A;

[0017] Step 6: Add a certain amount of pure water to another beaker, weigh disodium ethylenediaminetetraacetate and dissolve it completely, then add tartaric acid and dissolve it completely, and finally add polyvinylpyrrolidone K90 and dissolve it fully in water as phase B;

[0018] Step 7: Pour phase B into phase A, slowly stir until it does not flow, apply it evenly on the non-woven fabric backing layer, let it stand at room temperature for 72 hours, then cut and add white mustard seeds, and apply a protective layer to protect the drug matrix layer.

[0019] Usage method: The hydrogel acupoint eye patch prepared by the present invention is an innovative improvement on the prescription and usage method of "Gastrodia Tuiyi Powder" in "Yinhai Jingwei" (Volume 2), and the oral prescription is improved to realize external use of the internal prescription by the transdermal effect of white mustard and the slow drug delivery effect of the hydrogel matrix. When using, tear off the protective layer of the acupoint patch, stick it on the Yanglao acupoint, Guangming acupoint, Yiming acupoint, Jingming acupoint, Sibai acupoint, and Taiyang acupoint, and gently massage and knead to achieve better drug penetration and acupoint stimulation.

[0020] The acupuncture point patch prepared by the present invention has reasonable prescription composition, simple operation method, painless tearing, low sensitivity and no residue, good patient compliance, green and environmentally friendly, significant therapeutic effect and few toxic and side effects.

[0021] The beneficial effects of the present invention are:

[0022] 1. The present invention combines traditional Chinese medicine with modern transdermal absorption technology, can achieve sustained and controlled release of drugs, directly act on key acupoints such as Yanglao acupoint and Guangming acupoint, and significantly improve the bioavailability and therapeutic efficiency of effective ingredients; compared with oral Chinese medicine, the present invention reduces the stimulation and potential side effects of drugs on the digestive system through acupoint stickers, while reducing systemic pharmacological effects and reducing the physical burden on patients;

[0023] 2. The use of acupuncture patch is convenient for patients to self-manage and use, without complicated operation, which improves the compliance and treatment effect of patients; the hydrogel matrix of the present invention has good biocompatibility and skin affinity, reduces the risk of skin irritation and allergic reaction, and provides a safer and more comfortable treatment experience; by relieving the symptoms of hypertensive eye disease, the present invention helps to improve the patient's vision and quality of life, and reduce the psychological and social pressure caused by the disease;

[0024] 3. Compared with traditional injection and oral drug treatments, the acupuncture patch of the present invention may have lower production costs and longer shelf life, thereby saving costs for patients and the medical system; the present invention provides a new approach for the treatment of hypertensive eye diseases and provides a new option for patients who cannot accept conventional drug treatments. DETAILED DESCRIPTION

[0025] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0026] Example 1: This example provides a Chinese medicine compound hydrogel acupoint patch for treating hypertensive eye disease, and its formula includes the following Chinese medicinal ingredients: 4.5g of Tribulus terrestris, 3g of Gastrodia elata, 3g of Eucommia ulmoides, 3g of Chrysanthemum, 2.1g of Buddleja bud, 3g of Angelica sinensis, 3g of Rehmannia glutinosa, 4.5g of Ligusticum chuanxiong, 7.5g of Red Peony Root, 3g of Bombyx batryticatus, 1.8g of Periostracum cicadae, 3g of Notopterygium wilfordii, 3g of Saposhnikovia divaricata, 3g of Schizonepeta tenuifolia, 3g of Equisetum arvense, 3g of Semen Cassiae, 4.5g of Angelica dahurica, 2.1g of Licorice, 6g of Ophiopogon japonicus, 3g of Scutellaria baicalensis, 3g of Fructus Aurantii Immaturus, 3g of Vitex rotundifolia, 3g of Borneolum Syntheticum and 200g of Mint.

[0027] The hydrogel matrix material includes 1.2 g of diatomaceous earth, 25 g of glycerol and 1,2-propylene glycol (2:1), 6 g of sodium polyacrylate (NP-700), 0.5 g of aluminum glycinate, 3 ml of concentrated medicine, pure water, 0.3 g of disodium ethylenediaminetetraacetate, 0.2 g of tartaric acid, 1.5 g of polyvinylpyrrolidone K90 and white mustard.

[0028] The preparation method comprises the following steps: drying, mixing and crushing the components of Chinese medicinal materials after treatment to obtain medicinal powder; using 70% ethanol as a solvent, heating and extracting the medicinal powder and the solvent at a ratio of 1:10 for two times, filtering the extract with activated carbon absorption, and then concentrating it by rotary evaporation; adding borneol until it is dissolved to obtain a concentrated medicinal solution for use; extracting mint volatile oil for use; weighing diatomaceous earth and putting it into a beaker, adding glycerol and 1,2-propylene glycol, stirring evenly, and then adding sodium polyacrylate (NP-700), aluminum glycinate, and the concentrated medicinal solution; 3.0ml and 0.5g of peppermint volatile oil are continued to stir evenly as phase A; in another beaker, a certain amount of pure water is added, disodium ethylenediaminetetraacetate is weighed and dissolved completely, tartaric acid is added to dissolve it completely, and finally polyvinylpyrrolidone K90 is added to fully dissolve it in water as phase B; phase B is poured into phase A, slowly stirred until it does not flow, and evenly applied on the non-woven fabric backing layer, after standing at room temperature for 72 hours, it is cut and covered with white mustard, and a protective layer is applied to protect the drug matrix layer.

[0029] The method of use is to tear off the protective layer of the prepared hydrogel acupoint patch and stick it on the Yanglao acupoint, Guangming acupoint, Yiming acupoint, Jingming acupoint, Sibai acupoint and temple, and gently massage and knead to achieve better drug penetration and stimulation of the acupoints.

[0030] Example 2: This example provides a formula of a Chinese medicine compound hydrogel acupoint patch for treating hypertensive eye disease, characterized in that the formula includes the following Chinese medicinal ingredients: 4.5g of Tribulus terrestris, 3g of Gastrodia elata, 3g of Eucommia ulmoides, 3g of Chrysanthemum, 2.1g of Buddleja buddleja, 3g of Angelica sinensis, 3g of Rehmannia glutinosa, 4.5g of Ligusticum chuanxiong, 7.5g of Red Peony Root, 3g of Bombyx batryticatus, 1.8g of Periostracum cicadae, 3g of Notopterygium wilfordii, 3g of Saposhnikovia divaricata, 3g of Schizonepeta tenuifolia, 3g of Equisetum arvense, 3g of Semen Cassiae, 4.5g of Angelica dahurica, 2.1g of Licorice, 6g of Ophiopogon japonicus, 3g of Scutellaria baicalensis, 3g of Fructus Aurantii Immaturus and 3g of Vitex rotundifolia.

[0031] The hydrogel matrix material includes 1.2 g of diatomaceous earth, 25 g of glycerol and 1,2-propylene glycol (2:1), 6 g of sodium polyacrylate (NP-700), 0.5 g of aluminum glycinate, 3 ml of concentrated drug, pure water, 0.3 g of disodium ethylenediaminetetraacetate, 0.2 g of tartaric acid and 1.5 g of polyvinylpyrrolidone K90.

[0032] The preparation method comprises the following steps: drying, mixing and crushing the components of Chinese medicinal materials after treatment to obtain medicinal powder; using 70% ethanol as a solvent, heating and extracting the medicinal powder and the solvent at a ratio of 1:10 for two times, filtering the extract with activated carbon absorption, and then concentrating it by rotary evaporation; adding borneol until it is dissolved to obtain a concentrated medicinal solution for use; extracting mint volatile oil for use; weighing diatomaceous earth and putting it into a beaker, adding glycerol and 1,2-propylene glycol, stirring evenly, and then adding sodium polyacrylate (NP-700), aluminum glycinate, and the concentrated medicinal solution; 3.0ml and 0.5g of peppermint volatile oil are continued to stir evenly as phase A; in another beaker, a certain amount of pure water is added, disodium ethylenediaminetetraacetate is weighed and dissolved completely, tartaric acid is added to dissolve it completely, and finally polyvinylpyrrolidone K90 is added to fully dissolve it in water as phase B; phase B is poured into phase A, slowly stirred until it does not flow, and evenly applied on the non-woven fabric backing layer, after standing at room temperature for 72 hours, it is cut and covered with white mustard, and a protective layer is applied to protect the drug matrix layer.

[0033] The method of use is to tear off the protective layer of the prepared hydrogel acupoint patch and stick it on the Yanglao acupoint, Guangming acupoint, Yiming acupoint, Jingming acupoint, Sibai acupoint and temple, and gently massage and knead to achieve better drug penetration and stimulation of the acupoints.

[0034] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A formula of a Chinese medicine compound hydrogel acupoint patch for treating hypertensive eye disease, characterized in that: The formula includes the following Chinese medicinal ingredients: Tribulus terrestris, Gastrodia elata (fried to preserve its properties), Eucommia ulmoides, Chrysanthemum, Buddleja buddleja, Angelica sinensis (soaked in wine and dried), Rehmannia glutinosa (soaked in wine and dried), Ligusticum chuanxiong, Red Peony Root (soaked in hot water), Bombyx batryticatus (soaked in hot water, washed to remove silk, and fried with ginger juice), Periostracum cicadais (soaked in water, washed, and the head and feet removed), Notopterygium incisum, Saposhnikovia divaricata, Nepeta tenuifolia, Equisetum arvense (removed roots and nodes), Semen Cassiae (burned to preserve its properties), Angelica dahurica, Licorice, Ophiopogon japonicus, Scutellaria baicalensis, Fructus Aurantii Immaturus (fried), Vitex rotundifolia (slightly crushed), Borneolum and Mentha; The hydrogel matrix material comprises diatomaceous earth, glycerol, 1,2-propylene glycol, sodium polyacrylate, aluminum glycinate, disodium ethylenediaminetetraacetate, tartaric acid, polyvinylpyrrolidone K90 and white mustard.

2. The formula of the Chinese herbal compound hydrogel acupoint patch for treating hypertensive ophthalmopathy according to claim 1, characterized in that: The Chinese medicinal materials are mixed in the following proportions: 4.5g of Tribulus terrestris, 3g of Gastrodia elata, 3g of Eucommia ulmoides, 3g of Chrysanthemum, 2.1g of Buddleja buddha, 3g of Angelica sinensis, 3g of Rehmannia glutinosa, 4.5g of Ligusticum chuanxiong, 7.5g of Red Peony Root, 3g of Bombyx batryticatus, 1.8g of Periostracum cicadae, 3g of Notopterygium incisum, 3g of Saposhnikovia divaricata, 3g of Nepeta tenuifolia, 3g of Equisetum arvense, 3g of Semen Cassiae, 4.5g of Angelica dahurica, 2.1g of Licorice, 6g of Ophiopogon japonicus, 3g of Scutellaria baicalensis, 3g of Citrus aurantium, 3g of Vitex rotundifolia, 3g of Borneolum, and 200g of Menthus fragrans. Hydrogel matrix materials, diatomaceous earth 1.2g, glycerol and 1,2-propylene glycol (2:1) 25g in total, sodium polyacrylate (NP-700) 6g, aluminum glycinate 0.5g, concentrated drug 3ml, pure water, disodium ethylenediaminetetraacetic acid 0.3g, tartaric acid 0.2g, polyvinylpyrrolidone K901.5g, white mustard.

3. The formula of the Chinese medicine compound hydrogel acupoint patch for treating hypertensive ophthalmopathy according to any one of claims 1-2, characterized in that: The Chinese herbal ingredients in this formula have the effects of lowering blood pressure, improving eyesight, clearing away heat, detoxifying, and promoting blood circulation and removing blood stasis, and can effectively improve the symptoms of patients with hypertensive eye diseases.

4. A method for preparing a Chinese medicine compound hydrogel acupoint patch for treating hypertensive eye disease, characterized in that: The method comprises the following steps: Step 1: treating the Chinese medicinal material components of Tribulus terrestris, Gastrodia elata, Eucommia ulmoides, Chrysanthemum, Buddleja bud, Angelica sinensis, Rehmannia root, Chuanxiong, Red Peony Root, Bombyx batryticatus, Periostracum cicadae, Notopterygium wilfordii, Saposhnikovia divaricata, Nepeta tenuifolia, Equisetum arvense, Semen Cassiae, Angelica dahurica, Licorice, Ophiopogon japonicus, Scutellaria baicalensis, Fructus Aurantii Immaturus, and Fructus Viticis rotundifolia, drying, mixing and grinding to obtain a powder; Step 2: Using 70% ethanol as solvent, the drug powder and solvent are 1:10, heated and extracted twice, and the extract is filtered by activated carbon absorption and concentrated by rotary evaporation; Step 3: Add borneol until dissolved to obtain a concentrated solution for later use; Step 4: extracting peppermint volatile oil from peppermint for later use; Step 5: Weigh diatomaceous earth and put it into a beaker, add glycerol and 1,2-propylene glycol, stir evenly, then add sodium polyacrylate (NP-700), aluminum glycinate, 3.0 ml of concentrated drug solution and 0.5 g of peppermint volatile oil, and continue to stir evenly, as phase A; Step 6: Add a certain amount of pure water to another beaker, weigh disodium ethylenediaminetetraacetate and dissolve it completely, then add tartaric acid and dissolve it completely, and finally add polyvinylpyrrolidone K90 and dissolve it fully in water as phase B; Step 7: Pour phase B into phase A, stir slowly until it does not flow, apply it evenly on the non-woven fabric backing layer, let it stand at room temperature for 72 hours, then cut and add white mustard seeds, and apply a protective layer to protect the drug matrix layer.