Traditional Chinese medicine for treating hypertension and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine for treating hypertension, which is prepared from the following raw medicinal materials by weight: 14-16 g of gastrodia elata, 12-18 g of uncaria, 14-16 g of concha haliotidis, 8-12 g of eucommia ulmoides, 14-16 g of achyranthes bidentata, 8-12 g of parasitic loranthus, 6-14 g of cape jasmine, 8-12 g of scutellaria baicalensis, 6-14 g of motherwort, 14-16 g of poria with hostwood, 8-12 g of tuber fleeceflower stem, 25-35 g of salvia miltiorrhiza, 14-16 g of ligusticum wallichii and 12-18 g of chrysanthemum. The traditional Chinese medicine composition is scientific and reasonable in traditional Chinese medicine formula, can effectively regulate the body function of a patient and stabilize the blood pressure through the synergistic effect of the medicinal materials, has a remarkable curative effect after being taken persistently, adopts natural traditional Chinese medicinal materials, is small in side effect on a human body, avoids adverse reaction, is relatively low in cost, and relieves the economic burden of the patient.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine for treating hypertension and a preparation method thereof. Background Art

[0002] In today's society, hypertension has become a common chronic disease that seriously threatens people's health. With changes in lifestyle and the arrival of an aging society, the incidence of hypertension continues to rise.

[0003] At present, the existing technology mainly relies on Western medicine for the treatment of hypertension, but Western medicine often has some limitations. On the one hand, although many Western medicines have a certain effect in lowering blood pressure, they may bring some side effects, such as damage to organs such as the liver and kidneys, and cause discomfort symptoms such as dizziness and fatigue. Long-term use of Western medicine may also cause patients to become dependent on the medicine, and blood pressure is likely to rebound once the medicine is stopped; on the other hand, the cost of Western medicine treatment is relatively high, which brings a certain economic burden to patients. For some patients with limited economic conditions, long-term use of Western medicine to treat hypertension may face greater economic pressure. Summary of the invention

[0004] In view of the deficiencies of the prior art, the present invention provides a traditional Chinese medicine for treating hypertension and a preparation method thereof, which solves the problems of the prior art in treating hypertension with large side effects and high costs.

[0005] To achieve the above objectives, the present invention is implemented through the following technical scheme: a traditional Chinese medicine for treating hypertension, which is made of raw medicinal materials within the following weight ranges: Gastrodia elata 14-16g, Uncaria rhynchophylla 12-18g, Semen Cassiae 14-16g, Eucommia ulmoides 8-12g, Achyranthes bidentata 14-16g, Viscum album 8-12g, Gardenia jasminoides 6-14g, Scutellaria baicalensis 8-12g, Leonurus japonicus 6-14g, Poria 14-16g, Polygonum multiflorum 8-12g, Salvia miltiorrhiza 25-35g, Ligusticum chuanxiong 14-16g, and Chrysanthemum 12-18g.

[0006] Preferably, the dosage of each raw medicinal material is: Gastrodia elata 15g, Uncaria rhynchophylla 15g, Semen Cassiae 15g, Eucommia ulmoides 10g, Achyranthes bidentata 15g, Viscum album 10g, Gardenia 10g, Scutellaria baicalensis 10g, Leonurus japonicus 10g, Poria 15g, Polygonum multiflorum 10g, Salvia miltiorrhiza 30g, Ligusticum chuanxiong 15g, and Chrysanthemum 15g.

[0007] Preferably, it is characterized in that the dosage of each raw medicinal material is: Gastrodia elata 14g, Uncaria rhynchophylla 12g, Semen Cassiae 14g, Eucommia ulmoides 8g, Achyranthes bidentata 14g, Viscum album 8g, Gardenia jasminoides 6g, Scutellaria baicalensis 8g, Leonurus japonicus 6g, Poria 14g, Polygonum multiflorum 8g, Salvia miltiorrhiza 25g, Ligusticum chuanxiong 14g, and Chrysanthemum 12g.

[0008] Preferably, the dosage of each raw medicinal material is: Gastrodia elata 16g, Uncaria rhynchophylla 18g, Semen Cassiae 16g, Eucommia ulmoides 12g, Achyranthes bidentata 16g, Viscum album 12g, Gardenia jasminoides 14g, Scutellaria baicalensis 12g, Leonurus japonicus 14g, Poria 16g, Polygonum multiflorum 12g, Salvia miltiorrhiza 35g, Ligusticum chuanxiong 16g, and Chrysanthemum 18g.

[0009] Preferably, a method for preparing a traditional Chinese medicine for treating hypertension comprises the following steps:

[0010] S1. Weigh the above components according to the formula ratio;

[0011] S2. Mix the components of the herbs, add 5-8 times the total weight of the herbs in water, and soak for 20-40 minutes;

[0012] S3. Boil over high heat, then simmer for 30-40 minutes, filter the juice to obtain the first decoction;

[0013] S4. Add 3-5 times the total weight of herbs in water to the filtered residue, boil over high heat, then simmer for 20-30 minutes, filter the juice to obtain the second decoction;

[0014] S5. Combine the two drug solutions to obtain 300-400 ml of drug solution.

[0015] The present invention provides a traditional Chinese medicine for treating hypertension and a preparation method thereof. The traditional Chinese medicine has the following beneficial effects:

[0016] 1. The present invention uses a scientific and reasonable formula of traditional Chinese medicine, and the various medicinal materials work synergistically with each other, which can effectively regulate the patient's body functions and stabilize blood pressure. Adherent use has significant therapeutic effects, and natural traditional Chinese medicinal materials are used, which have little side effects on the human body and avoid the occurrence of adverse reactions.

[0017] 2. The cost of the Chinese medicinal materials of the present invention is relatively low, which reduces the economic burden on patients. Compared with some expensive Western medicine treatments or complicated medical methods, the Chinese medicine of the present invention provides patients with an economically feasible treatment option. DETAILED DESCRIPTION

[0018] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0019] Embodiment 1:

[0020] The embodiment of the present invention provides a traditional Chinese medicine for treating hypertension, wherein the dosage of each raw medicinal material is: 15g of Gastrodia elata, 15g of Uncaria rhynchophylla, 15g of Semen Cassiae, 10g of Eucommia ulmoides, 15g of Achyranthes bidentata, 10g of Viscum album, 10g of Gardenia jasminoides, 10g of Scutellaria baicalensis, 10g of Leonurus japonicus, 15g of Poria, 10g of Polygonum multiflorum, 30g of Salvia miltiorrhiza, 15g of Ligusticum chuanxiong, and 15g of Chrysanthemum.

[0021] Among them, Gastrodia elata is sweet and neutral in nature. Among antihypertensive drugs, Gastrodia elata plays a key role in calming the liver and calming the wind. It can inhibit the excessive rise of liver yang, relieve the common dizziness and headache symptoms of hypertensive patients, stabilize the hyperactive qi and blood, and regulate the hypertension caused by the hyperactive liver yang from the root;

[0022] Uncaria rhynchophylla is sweet in taste and cool in nature. Its main functions are to clear away heat and calm the liver, calm wind and calm convulsions. The active ingredients in Uncaria rhynchophylla can act on the vasomotor center to dilate peripheral blood vessels, thereby lowering blood pressure. It also has an effect on relieving mood swings and convulsion symptoms caused by hypertension.

[0023] Semen Cassiae is salty in taste and cold in nature. As an important herbal medicine for calming the liver and suppressing yang, Semen Cassiae can calm the hyperactive liver yang and improve the dizziness symptoms of patients with hypertension. It achieves the effect of assisting in lowering blood pressure by regulating the balance of yin and yang in the human body and preventing yang from rushing upward.

[0024] Eucommia ulmoides is sweet and warm in nature. Its role in antihypertensive drugs is to nourish the liver and kidneys. Hypertension is related to liver and kidney deficiency. Eucommia ulmoides can nourish the liver and kidneys, enhance the body's regulatory ability, and promote the balance of yin and yang in the body, thus helping to stabilize blood pressure.

[0025] Achyranthes bidentata tastes bitter, sweet and sour, and is neutral in nature. It has the special effect of guiding blood downward. For patients with hypertension, it can guide the upward rushing blood downward, reduce congestion and pressure in the head, and relieve symptoms such as dizziness and vertigo, thus playing a positive role in lowering blood pressure.

[0026] Mulberry parasite tastes bitter and sweet, and is neutral in nature. It can nourish the liver and kidneys, and strengthen the bones and muscles. In terms of lowering blood pressure, it can adjust the body's internal balance by nourishing the liver and kidneys, and improve symptoms such as soreness of the waist and knees, and weakness of the bones and muscles caused by high blood pressure, thereby cooperating with other medicinal materials to control blood pressure.

[0027] Gardenia tastes bitter and is cold in nature. It can clear away heat and relieve restlessness. In the treatment of hypertension, it can clear away heat evil, make Qi and blood flow smoothly, and alleviate the symptoms of hypertension caused by heat evil disturbing Qi and blood.

[0028] Scutellaria baicalensis is bitter in taste and cold in nature. It has the effects of clearing away heat and dampness, purging fire and detoxifying. Among antihypertensive drugs, Scutellaria baicalensis can clear away dampness and heat, have a certain protective effect on blood vessels, reduce vascular inflammation, thereby reducing vascular resistance and helping to stabilize blood pressure;

[0029] Motherwort tastes bitter and pungent, and is slightly cold in nature. The blood-activating and menstrual-regulating effects of motherwort help improve the blood circulation of patients with hypertension, prevent blood stasis, reduce the pressure on the blood vessel walls, and have a positive regulating effect on the cardiovascular system to promote blood pressure stability.

[0030] Poria is sweet, light and neutral in nature. Its main function among antihypertensive drugs is to calm the mind and soothe the nerves. Hypertensive patients are prone to mood swings and sleep problems. Poria regulates the nervous system, stabilizes emotions and helps control blood pressure through its calming effect.

[0031] Polygonum multiflorum is sweet and neutral in nature. Its properties of nourishing blood and calming the mind, dispelling wind and unblocking meridians can improve the sleep quality of patients with hypertension and stabilize the nervous system. At the same time, dispelling wind and unblocking meridians can help promote blood circulation and have a positive significance for overall blood pressure regulation.

[0032] Danshen tastes bitter and is slightly cold in nature. It is an important herbal medicine for promoting blood circulation and removing blood stasis. Among antihypertensive drugs, it can improve blood circulation, prevent thrombosis, reduce blood vessel wall pressure, protect the vascular endothelium, promote vascular endothelial repair, and is beneficial for stabilizing blood pressure and preventing complications.

[0033] Chuanxiong is pungent in taste and warm in nature. It is a blood-qi medicine that can both invigorate blood circulation and promote qi circulation. In the treatment of hypertension, Chuanxiong promotes the smooth flow of qi and blood, relieves vascular tension, dilates cerebral blood vessels, improves dizziness and headache symptoms, and thus helps lower blood pressure.

[0034] Chrysanthemum tastes sweet and bitter and is slightly cold in nature. It has the effects of clearing the liver and improving eyesight, calming the liver and suppressing yang. Among antihypertensive drugs, chrysanthemum can suppress hyperactive liver yang, clear away liver heat evil, relieve symptoms of dizziness, and also relieve eye discomfort caused by high blood pressure, assisting in lowering blood pressure.

[0035] A method for preparing a traditional Chinese medicine for treating hypertension comprises the following steps:

[0036] S1. Weigh the above components according to the formula ratio;

[0037] S2. Mix the various components of the herbs, add 6 times the total weight of the herbs in water, and soak for 30 minutes;

[0038] S3. Boil over high heat, then simmer for 35 minutes, filter the juice to obtain the first decoction;

[0039] S4. Add 4 times the total weight of herbs in water after filtering the residue, boil over high heat, then simmer for 25 minutes, filter the juice to obtain the second decoction;

[0040] S5. Combine the two drug solutions to obtain 380 ml of drug solution.

[0041] Embodiment 2:

[0042] The embodiment of the present invention provides a traditional Chinese medicine for treating hypertension, wherein the dosage of each raw medicinal material is: 14g of Gastrodia elata, 12g of Uncaria rhynchophylla, 14g of Semen Cassiae, 8g of Eucommia ulmoides, 14g of Achyranthes bidentata, 8g of Viscum album, 6g of Gardenia jasminoides, 8g of Scutellaria baicalensis, 6g of Leonurus japonicus, 14g of Poria, 8g of Polygonum multiflorum, 25g of Salvia miltiorrhiza, 14g of Ligusticum chuanxiong, and 12g of Chrysanthemum.

[0043] A method for preparing a traditional Chinese medicine for treating hypertension comprises the following steps:

[0044] S1. Weigh the above components according to the formula ratio;

[0045] S2. Mix the various components of the herbs, add 5 times the total weight of the herbs in water, and soak for 20 minutes;

[0046] S3. Boil over high heat, then simmer for 30 minutes, filter the juice to obtain the first decoction;

[0047] S4. Add 3 times the total weight of herbs in water to the filtered residue, boil over high heat, then simmer for 25 minutes, filter the juice to obtain the second decoction;

[0048] S5. Combine the two drug solutions to obtain 360 ml of drug solution.

[0049] Embodiment three:

[0050] The embodiment of the present invention provides a traditional Chinese medicine for treating hypertension, wherein the dosage of each raw medicinal material is: 16g of Gastrodia elata, 18g of Uncaria rhynchophylla, 16g of Semen Cassiae, 12g of Eucommia ulmoides, 16g of Achyranthes bidentata, 12g of Viscum album, 14g of Gardenia jasminoides, 12g of Scutellaria baicalensis, 14g of Leonurus japonicus, 16g of Poria, 12g of Polygonum multiflorum, 35g of Salvia miltiorrhiza, 16g of Ligusticum chuanxiong, and 18g of Chrysanthemum.

[0051] A method for preparing a traditional Chinese medicine for treating hypertension comprises the following steps:

[0052] S1. Weigh the above components according to the formula ratio;

[0053] S2. Mix the various components of the herbs, add 8 times the total weight of the herbs in water, and soak for 40 minutes;

[0054] S3. Boil over high heat, then simmer for 40 minutes, filter the juice to obtain the first decoction;

[0055] S4. Add 5 times the total weight of herbs in water to the filtered residue, boil over high heat, then simmer for 25 minutes, filter the juice to obtain the second decoction;

[0056] S5. Combine the two drug solutions to obtain 400 ml of drug solution.

[0057] 60 patients with grade 1 hypertension of liver yang hyperactivity type recruited from the society and diagnosed with hypertension were selected. The diagnostic criteria were as follows: normal blood pressure: systolic blood pressure less than 140 mmHg (mmHg), diastolic blood pressure less than 90 mmHg; hypertension: systolic blood pressure equal to or higher than 140 mmHg, diastolic blood pressure equal to or higher than 90 mmHg. Hypertension classification: grade 1 hypertension: systolic blood pressure 140-159 mmHg or diastolic blood pressure 90-99 mmHg; grade 2 hypertension: systolic blood pressure 160-179 mmHg or diastolic blood pressure 100-109 mmHg; grade 3 hypertension: systolic blood pressure greater than or equal to 180 or diastolic blood pressure greater than or equal to 110; inclusion criteria: age 20-65 years old, diagnosed by clinical symptoms and blood pressure measurement, and no drug treatment was given within 2 weeks before enrollment. Exclusion criteria: patients with cerebrovascular disease; patients with lesions of important organs such as heart, liver, brain, kidney, mental illness, incomplete data, and unwilling to cooperate. The patients were randomly divided into a control group and a treatment group, with 30 people in each group. The control group was given health education on hypertension and guidance on adjusting bad living habits. The treatment group was given the oral Chinese medicine prepared by the embodiment of the present invention on the basis of the treatment of the control group. There was no statistical difference in the general data of the two groups such as gender, age, course of disease, and lesion site. All the selected patients signed informed consent forms and obtained approval from the hospital ethics committee.

[0058] Control group: 30 patients with grade 1 hypertension of liver yang hyperactivity type, who were given health education on hypertension and guidance on adjusting bad living habits for three months;

[0059] Treatment effect: 10% of patients' blood pressure dropped to normal blood pressure standards, 30% of patients' blood pressure improved but was still at the hypertensive level, and 60% of patients' blood pressure did not improve significantly. Among them, patient Zhao, male, 52 years old, had hypertension for 4 years, with a blood pressure of 165 / 105mmHg. After 3 months, although the patient's blood pressure dropped to a certain extent, it was still unstable, around 150 / 95mmHg, and there was no significant improvement in symptoms such as dizziness and fatigue.

[0060] Treatment group: 30 patients with grade 1 hypertension of liver yang hyperactivity type were given oral Chinese medicine prepared in the embodiment of the present invention on the basis of the treatment of the control group, with one dose of Chinese medicine taken twice a day with warm water for three months;

[0061] Treatment effect: 80% of patients' blood pressure was reduced to normal blood pressure standard, and 20% of patients' blood pressure was improved. Among them, Zhang, a 55-year-old male patient who took the Chinese medicine prepared by Example 1, suffered from hypertension for 3 years, and his blood pressure fluctuated at about 160 / 100mmHg. After 3 months of treatment, the patient's blood pressure was stabilized at about 135 / 85mmHg, and symptoms such as dizziness and headache were significantly alleviated; Li, a 60-year-old female patient who took the Chinese medicine prepared by Example 2, had a history of hypertension for 5 years, and her blood pressure was often 170 / 110mmHg. After 3 months, her blood pressure dropped to below 145 / 95mmHg, and symptoms such as palpitations and insomnia were improved; Wang, a 48-year-old male patient who took the Chinese medicine prepared by Example 3, had newly discovered hypertension, with a blood pressure of 155 / 95mmHg. After 3 months, her blood pressure returned to normal without obvious discomfort.

[0062] In summary, the embodiments of the present invention provide three different formulations of Chinese medicine for treating hypertension and preparation methods. Through a control test on 60 patients with grade 1 hypertension of liver yang hyperactivity type, the control group only carried out health education and adjusted bad living habits, and the effect was not good. On the basis of the control group, the treatment group was given the Chinese medicine of the present invention, and significant results were achieved. The blood pressure of 80% of the patients was reduced to the normal standard, and the blood pressure of 20% of the patients was improved, and the symptoms of the patients were significantly alleviated. It can be seen that the Chinese medicine of the present invention is effective in treating hypertension, which brings new treatment options for hypertensive patients and has a high clinical application value.

[0063] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine for treating hypertension, characterized in that: It is made from raw medicinal materials within the following weight range: Gastrodia elata 14-16g, Uncaria rhynchophylla 12-18g, Semen Cassiae 14-16g, Eucommia ulmoides 8-12g, Achyranthes bidentata 14-16g, Viscum album 8-12g, Gardenia jasminoides 6-14g, Scutellaria baicalensis 8-12g, Leonurus japonicus 6-14g, Poria 14-16g, Polygonum multiflorum 8-12g, Salvia miltiorrhiza 25-35g, Ligusticum chuanxiong 14-16g, Chrysanthemum 12-18g.

2. A Chinese medicine for treating hypertension according to claim 1, characterized in that: The dosage of each raw medicinal material is as follows: Gastrodia elata 15g, Uncaria rhynchophylla 15g, Semen Cassiae 15g, Eucommia ulmoides 10g, Achyranthes bidentata 15g, Viscum album 10g, Gardenia 10g, Scutellaria baicalensis 10g, Leonurus japonicus 10g, Poria 15g, Polygonum multiflorum 10g, Salvia miltiorrhiza 30g, Ligusticum chuanxiong 15g, and Chrysanthemum 15g.

3. A Chinese medicine for treating hypertension according to claim 1, characterized in that: The dosage of each raw medicinal material is as follows: Gastrodia elata 14g, Uncaria rhynchophylla 12g, Semen Cassiae 14g, Eucommia ulmoides 8g, Achyranthes bidentata 14g, Viscum album 8g, Gardenia jasminoides 6g, Scutellaria baicalensis 8g, Leonurus japonicus 6g, Poria 14g, Polygonum multiflorum 8g, Salvia miltiorrhiza 25g, Ligusticum chuanxiong 14g, and Chrysanthemum 12g.

4. A Chinese medicine for treating hypertension according to claim 1, characterized in that: The dosage of each raw medicinal material is as follows: Gastrodia elata 16g, Uncaria rhynchophylla 18g, Semen Cassiae 16g, Eucommia ulmoides 12g, Achyranthes bidentata 16g, Viscum album 12g, Gardenia jasminoides 14g, Scutellaria baicalensis 12g, Leonurus japonicus 14g, Poria 16g, Polygonum multiflorum 12g, Salvia miltiorrhiza 35g, Ligusticum chuanxiong 16g, and Chrysanthemum 18g.

5. The method for preparing a traditional Chinese medicine for treating hypertension according to claim 1, characterized in that: The following steps are involved: S1. Weigh the above components according to the formula ratio; S2. Mix the components of the herbs, add 5-8 times the total weight of the herbs in water, and soak for 20-40 minutes; S3. Boil over high heat, then simmer for 30-40 minutes, filter the juice to obtain the first decoction; S4. Add 3-5 times the total weight of herbs in water to the filtered residue, boil over high heat, then simmer for 20-30 minutes, filter the juice to obtain the second decoction; S5. Combine the two drug solutions to obtain 300-400 ml of drug solution.