Traditional Chinese medicine composition for treating rhinitis

Abstract

The invention discloses a traditional Chinese medicine composition for treating rhinitis, which is prepared from the following components in parts by weight: 10-20 parts of codonopsis pilosula, 15-30 parts of poria cocos, 10-20 parts of bighead atractylodes rhizome, 10-20 parts of Chinese yam, 5-10 parts of rhizoma acori graminei, 10-20 parts of platycodon grandiflorum, 5-10 parts of endothelium corneum gigeriae galli and 10-20 parts of fried white hyacinth bean. The traditional Chinese medicine has the advantages that the curative effect is stable; various medicinal materials are reasonably proportioned; the treatment cycle is short, and the symptoms of patients can be remarkably improved in the short treatment cycle; the safety is high, and no serious adverse reaction is caused.

Description

Technical Field

[0001] The invention belongs to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating rhinitis. Background Art

[0002] Rhinitis is a common chronic respiratory disease with symptoms such as nasal congestion, runny nose, sneezing, etc., which bring great inconvenience to patients' lives and work. At present, the methods for treating rhinitis mainly include drug therapy and surgical treatment. In drug treatment, Western medicine is widely used because of its characteristics of rapid symptom relief, but long-term use may lead to drug tolerance and side effects, and it is easy to relapse after discontinuation of the drug. Traditional Chinese medicine treatment is favored by more and more patients because of its natural nature, few side effects and long-lasting efficacy. However, the existing traditional Chinese medicine treatment schemes still have shortcomings in efficacy and stability.

[0003] At present, traditional Chinese medicine programs for the treatment of rhinitis mostly use single herbs or simple combinations of herbs, such as Scutellaria baicalensis and Forsythia suspensa for clearing away heat and detoxifying, or Xanthium sibiricum for dispersing wind and opening the orifices. Although these programs can relieve symptoms to a certain extent, due to their single mechanism of action, they are often unable to comprehensively improve the various symptoms of rhinitis, and their applicability to different patients is limited. This program is mainly manifested in the following aspects: Unstable efficacy: Due to the single combination of herbs, it is difficult to cover the complex causes of rhinitis, resulting in unstable efficacy. Long treatment cycle: Patients need to take the drug for a long time to feel significant improvement, which reduces the patient's compliance with treatment. Safety issues: Some herbs may have potential toxic side effects, and long-term use may have adverse effects on the patient's health.

[0004] Traditional Chinese medicine calls allergic rhinitis "nasal allergy". Its etiology and pathogenesis are mainly based on the deficiency of the lungs, spleen and kidneys. Traditional Chinese medicine adheres to the holistic concept in the treatment of allergic rhinitis, treats according to individual needs, and treats according to syndrome differentiation. It has the advantages of treating both the symptoms and the root causes, good efficacy, high cure rate, safety and reliability, and low toxicity and side effects. There is still a lot of room for research in the prevention and treatment of allergic rhinitis. However, the therapeutic effects of the existing traditional Chinese medicine formulas for the treatment of rhinitis are limited. Therefore, further exploring drugs used in the treatment of allergic rhinitis from the field of traditional Chinese medicine to provide more abundant choices for the formulation of clinical medication plans has become a technical problem that needs to be solved urgently. Summary of the invention

[0005] The Chinese medicine composition provided by the present invention is composed of the following medicinal materials, which work synergistically with each other to treat rhinitis:

[0006] A traditional Chinese medicine composition for treating rhinitis is prepared from the following components by weight: 10-20 parts of Codonopsis pilosula, 15-30 parts of Poria cocos, 10-20 parts of Atractylodes macrocephala, 10-20 parts of Dioscorea opposita, 5-10 parts of Acorus calamus, 10-20 parts of Platycodon grandiflorum, 5-10 parts of Gallus gallus domesticus, and 10-20 parts of stir-fried white hyacinth bean.

[0007] Preferably, the Chinese medicine composition is prepared from the following Chinese medicines in parts by weight: 10 parts of Codonopsis pilosula, 15 parts of Poria cocos, 10 parts of Atractylodes macrocephala, 10 parts of Dioscorea opposita, 5 parts of Acorus calamus, 10 parts of Platycodon grandiflorum, 5 parts of Gallus gallus domesticus, and 10 parts of stir-fried white hyacinth bean.

[0008] Preferably, the Chinese medicine composition uses Codonopsis pilosula, Poria cocos and Atractylodes macrocephala as the main medicines, which together play the role of invigorating Qi, strengthening the spleen and eliminating dampness, while Chinese yam and Acorus calamus are used as auxiliary medicines to help invigorate the spleen and invigorate Qi. The total amount of Codonopsis pilosula + Poria cocos + Atractylodes macrocephala to the total amount of Chinese yam + Acorus calamus is between 2 / 1 and 7 / 3.

[0009] Furthermore, the Chinese medicine composition for treating rhinitis is a decoction.

[0010] Codonopsis: replenishes qi and strengthens the body's resistance. Nasal congestion is usually caused by a cold, or rhinitis or sinusitis. Codonopsis is usually a herbal medicine with a qi-replenishing effect. Eating some Codonopsis can usually replenish qi and strengthen the body's resistance. It can also appropriately improve the symptoms of nasal congestion.

[0011] Poria: Strengthens the spleen and eliminates dampness, improves nasal congestion symptoms. Because Poria contains a lot of vitamins, it can increase the resistance of the nasal mucosa and relieve symptoms such as nasal congestion and runny nose caused by rhinitis.

[0012] Atractylodes macrocephala: Atractylodes macrocephala is a traditional Chinese medicine with a sweet and bitter taste and warm nature. It belongs to the spleen and stomach meridians. It has the effects of strengthening the spleen and replenishing qi, drying dampness and promoting diuresis. It is mainly used to treat spleen and stomach weakness, poor appetite, fatigue, vomiting and diarrhea. Patients with chronic rhinitis can use Atractylodes macrocephala to play a certain role in replenishing qi and thus improving the discomfort symptoms.

[0013] Yam: . Yam has the effects of nourishing the lungs and replenishing qi, strengthening the exterior and stopping sweating, and can help relieve nasal congestion caused by lung deficiency.

[0014] Acorus calamus: Acorus calamus can usually play the role of opening the orifices and clearing phlegm, as well as the effect of regulating qi and activating blood circulation, and can also play the role of removing dampness.

[0015] Platycodon grandiflorum: Platycodon grandiflorum is a traditional Chinese medicine with the effects of clearing the lungs, removing phlegm, relieving sore throat and draining pus. Platycodon grandiflorum has the effects of clearing the lungs and removing phlegm, and can relieve discomfort such as nasal congestion.

[0016] Chicken's gizzard lining: It strengthens the stomach and aids digestion, astringes semen and stops nocturnal emission, and can help indigestion caused by spleen deficiency.

[0017] Fried white lentils: strengthen the spleen and stop diarrhea, enhance physical fitness.

[0018] In the prescription, Codonopsis pilosula, Poria cocos, and Atractylodes macrocephala are the main drugs, which work together to invigorate qi, strengthen the spleen, and eliminate dampness; Chinese yam and Acorus calamus are used as the assistants to help invigorate the spleen and invigorate qi, and chicken gizzard lining is used to help digestion and invigorate the spleen, Platycodon grandiflorum is used to promote lung function and benefit qi and carry medicine upward; White hyacinth bean is used to invigorate the spleen and eliminate dampness. This medicine is guided by the theoretical method of "cultivating soil to produce gold" in traditional Chinese medicine, and has the functions of invigorating the spleen and eliminating dampness, invigorating qi and opening the orifices. The connotation is to enhance the digestive function of the human spleen and stomach, thereby enhancing the human immune function, promoting blood circulation and inflammation absorption in the respiratory tract, improving the hypersecretion of airway mucus, and thus reducing airway inflammation. This prescription is not only a manifestation of the application of the relationship between the lung and spleen, but also an innovative application of the nose-lung-spleen relationship in clinical treatment in combination with the unique physiological characteristics and pathological characteristics of the nose. It is clinically applied to patients with rhinitis of spleen deficiency and dampness, and has significant efficacy.

[0019] The following are the specific preparation methods and use methods of the present invention:

[0020] (1) Before decocting the Chinese medicine, wash it in running water and then soak it in clean water for about 30 minutes to 1 hour;

[0021] (2) After soaking, simmer over high heat for 20 minutes, then turn to low heat to stew the medicinal juice;

[0022] (3) After pouring out the medicinal liquid, add water again to cover the medicinal materials. Bring the heat to a boil, then turn to low heat. The second decoction needs to take 15 minutes.

[0023] (4) After decocting, mix the first and second decoctions, keep warm, and take in the morning and evening;

[0024] (5) Before taking the medicine, inhale the steam emitted by the medicine through your nose until the medicine reaches a suitable temperature before drinking.

[0025] (6) Avoid eating raw, cold and spicy food while taking the medicine, and get plenty of sun to stimulate Yang energy.

[0026] The present invention has the following significant effects: stable therapeutic effect. Through the reasonable ratio of multiple medicinal materials, the present invention can provide a stable therapeutic effect for rhinitis of spleen deficiency and dampness type; short treatment cycle, oral administration combined with nasal inhalation for external use, promotes blood circulation and inflammation absorption in the respiratory tract, improves high secretion of airway mucus, thereby reducing airway inflammation and relieving nasal symptoms. The present invention can improve the symptoms of patients within a relatively short treatment cycle and improve the quality of life of patients. High safety. The medicinal materials selected by the present invention are all traditional and commonly used Chinese medicines, and have been clinically verified to have no serious adverse reactions. DETAILED DESCRIPTION

[0027] The present invention is further described in detail below in conjunction with clinical verification and specific embodiments:

[0028] 1. Western medicine diagnostic criteria: The inclusion criteria refer to the relevant standards in the "Guidelines for the Diagnosis and Treatment of Allergic Rhinitis in China (2022, revised edition)". TCM diagnostic criteria: The inclusion criteria are based on the TCM symptom diagnostic criteria for allergic rhinitis in the national TCM industry higher education textbook "Chinese Medicine Otorhinolaryngology", and the syndrome type is spleen deficiency syndrome.

[0029] 2. Exclusion criteria: (1) Patients with other airway allergic diseases such as bronchial asthma; patients with primary ciliary immobility syndrome, cystic fibrosis, fungal sinusitis, autoimmune diseases, aspirin intolerance triad, and various benign and malignant tumors of the nasal cavity and paranasal sinuses; (2) Patients with a known history of autoimmune diseases, such as rheumatoid arthritis, irritable bowel syndrome, or inflammatory bowel disease; (3) Patients with a history of malignant tumors or gastrointestinal surgery; (4) Pregnant and lactating patients.

[0030] 3. Source of patients: All cases were from the outpatient department of Otolaryngology, the First Affiliated Hospital of Hunan University of Chinese Medicine.

[0031] Patient profile: All cases from 2023 to 2024 were selected, all of which were patients who met the diagnostic criteria for chronic rhinitis in the Department of Otolaryngology and were diagnosed with chronic rhinitis by clinical examination. A total of 107 cases, including 49 males and 58 females; the course of disease ranged from 6 to 24 months, with an average of 13.4±2.8 months.

[0032] Patients who met the case selection criteria were randomly divided into a treatment group and a control group according to the random grouping method. Among them, the treatment group: 53 cases, 24 males, 29 females; the course of disease was 6 months to 24 months, with an average of 13.9±3.6 months. The control group: 54 cases, 25 males, 29 females; the course of disease was 6 months to 24 months, with an average of 13.1±1.8 months. The above cases were statistically processed in terms of gender, course of disease, etc., and there was no significant difference (P>0.05), which was comparable. All subjects were informed and signed informed consent.

[0033] 4. Treatment Methods

[0034] Treatment group: took the Chinese medicine decoction prepared in Example 1 orally, twice a day.

[0035] Control group: treated with nasal spray of fluticasone propionate, according to the instructions. The fluticasone propionate was purchased from GlaxoWellcome.SA (National Medicine Standard HJ20140117).

[0036] Each group had a course of treatment of 15 days, and the drugs were used together for 1 month, during which time other drugs for the treatment of allergic rhinitis were discontinued.

[0037] 5. Observation indicators

[0038] ①Safety observation: including general vital signs (blood pressure, heart rate, respiration), blood routine, urine routine, heart, liver and kidney function tests and adverse reaction detection.

[0039] ②Efficacy observation:

[0040] Efficacy evaluation: Markedly effective: clinical symptoms showed significant improvement; Effective: the patient's clinical symptoms were relieved; Ineffective: the patient's clinical symptoms had no significant change.

[0041] TCM syndrome scoring: TCM syndrome quantitative standards: TCM syndrome quantitative standards are formulated according to the relevant standards in the TCM syndrome diagnosis and efficacy standards. Including nasal itching, runny nose, nasal congestion, sneezing, coughing, red and itchy eyes, epistaxis, loose stools, fatigue, poor appetite and other symptoms. Each symptom is divided into four levels: normal, mild, moderate and severe, and recorded as 0, 1, 2, and 3 points respectively, with a total score of 30 points.

[0042] Incidence of adverse nasal reactions: mainly includes nasal bleeding, ulcers or erosions, diarrhea, dizziness, headache and other discomfort symptoms caused by medication during treatment.

[0043] 6. Efficacy evaluation

[0044] Table 1 is the efficacy evaluation: after the treatment of the present invention, the symptoms and signs of the patients were significantly relieved, proving that the present invention has good clinical efficacy, and compared with the control group, the total effective rate of the two drugs is significantly different (P≤0.05), and the effective rate of the Chinese medicine group is higher than that of the control group, and the difference is statistically significant (P≤0.01).

[0045] Table 1 Comparison of efficacy evaluation between the two groups

[0046]

[0047] Table 2 shows the TCM syndrome scores: the TCM syndrome scores of patients after treatment with the present invention were significantly reduced, and the difference was statistically significant (P≤0.05); and the TCM syndrome scores after treatment were significantly lower than those of the control group, and the difference was statistically significant (P≤0.05).

[0048] Table 2 Comparison of SNOT-20 scores between the two groups

[0049]

[0050] Incidence of nasal adverse reactions: During the treatment period, 6 cases of adverse reactions occurred in the control group, with an incidence of 11.11%; 1 case of adverse reactions occurred in the treatment group, with an incidence of 3.77%. The incidence of adverse reactions in the treatment group was lower than that in the control group (P≤0.05).

[0051] Embodiment 1: Patient female, age 25 years old, has had repeated nasal congestion and runny nose in the past year, accompanied by sneezing, frequent attacks during the change of seasons, and nasal itching from time to time. Now has nasal congestion and runny nose, feels weak on weekdays, has good appetite, soft stool, good urination, and general sleep. Tongue is fat, white fur, and slippery pulse. Chinese medicine diagnosis: allergic rhinitis, spleen deficiency and dampness syndrome. Treatment: invigorate the spleen and penetrate dampness, invigorate qi and open the orifices. Prescription: Codonopsis pilosula 10g, Poria 15g, Atractylodes macrocephala 10g, Chinese yam 10g, Acorus gramineus 5g, Platycodon grandiflorum 10g, Gallus gallus domesticus 10g, stir-fried white lentil 10g. 9 pairs, decocted, divided into morning and evening, and inhaled the steam of the liquid before taking the medicine. After taking: nasal congestion is relieved without runny nose, fatigue is significantly improved, appetite is good, stool is good, urination is good, and sleep is improved.

[0052] Embodiment 2: Patient male, age 45 years old, has had repeated nasal congestion and nasal itching in the past ten years, frequent sneezing, and attacks every time he encounters cold air. He is relieved after dozens of consecutive sneezing, accompanied by clear watery nasal discharge. Now he has nasal congestion and nasal itching, feels tired during the day, sleepiness, likes to eat fatty and greasy food, has loose stools, and can urinate. The tongue is fat with tooth marks, white and greasy fur, and the pulse is deep and slippery. Chinese medicine diagnosis: allergic rhinitis, spleen deficiency and dampness syndrome. Treatment method: invigorate the spleen and penetrate dampness, invigorate qi and open the orifices. Prescription: Codonopsis pilosula 10g, Poria 15g, Atractylodes macrocephala 10g, Chinese yam 11g, Acorus gramineus 6g, Platycodon grandiflorum 10g, Gallus gallus domesticus 10g, stir-fried white lentil 10g. A total of 15 pairs, decocted and taken, divided into morning and evening, and the steam of the liquid medicine is inhaled before taking the medicine. After taking: no runny nose after encountering cold air, nasal congestion and nasal itching have improved a lot, no fatigue, sleep improvement, can defecate, can urinate.

[0053] This specific embodiment is merely an explanation of the present invention and is not a limitation of the present invention. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed. However, as long as they are within the scope of the claims of the present invention, they are protected by the patent law.

Claims

1. A Chinese medicine composition for treating rhinitis, characterized in that: The invention is prepared from the following components by weight: 10-20 parts of Codonopsis pilosula, 15-30 parts of Poria cocos, 10-20 parts of Atractylodes macrocephala, 10-20 parts of Dioscorea opposita, 5-10 parts of Acorus calamus, 10-20 parts of Platycodon grandiflorum, 5-10 parts of Gallus gallus domesticus, and 10-20 parts of stir-fried white hyacinth bean.

2. The Chinese medicine composition for treating rhinitis according to claim 1, characterized in that: By weight, 10 parts of Codonopsis pilosula, 15 parts of Poria cocos, 10 parts of Atractylodes macrocephala, 10 parts of Dioscorea opposita, 5 parts of Acorus calamus, 10 parts of Platycodon grandiflorum, 10 parts of Chicken's gizzard lining, and 10 parts of stir-fried white lentils.

3. The Chinese medicine composition for treating rhinitis according to claim 1, characterized in that: The Chinese medicine composition uses Codonopsis pilosula, Poria cocos and Atractylodes macrocephala as the main medicines, which work together to invigorate qi, strengthen the spleen and eliminate dampness. Chinese yam and Acorus calamus are used as assistant medicines to help invigorate the spleen and invigorate qi. The total amount of Codonopsis pilosula + Poria cocos + Atractylodes macrocephala and the total amount of Chinese yam + Acorus calamus are in a ratio of 2 / 1 to 7 / 3.

4. The Chinese medicine composition for treating rhinitis according to claim 1, characterized in that: The Chinese medicine composition is a decoction.

5. A method for preparing a Chinese medicine composition for treating rhinitis, characterized in that: The following steps are involved: (1) Before decocting the Chinese medicine, wash it in running water, then soak it in clean water for about 30 minutes to 1 hour; (2) After soaking, boil it over high heat for 20 minutes, then turn to low heat to stew the medicinal juice; (3) After pouring out the medicinal liquid, add water again to cover the medicinal materials, boil it over high heat, then turn to low heat, and boil it for the second time for 15 minutes; (4) After decocting, mix the medicinal materials from the first and second decoctions, keep them warm, and take them in the morning and evening; (5) Before taking the medicine, inhale the steam emitted by the medicinal liquid with your nose until the medicinal liquid is at a suitable temperature before drinking.

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