A children's bionic vernix caseosa skin care composition and its preparation method and application

Abstract

The present invention discloses a children's bionic vernix caseosa skin care composition and a preparation method and application thereof, and belongs to the technical field of skin care products. The bionic vernix caseosa skin care composition in the present invention comprises a plant extract, a bionic vernix caseosa composition, a protein mixture, a regulator and a bionic fluid. The present invention utilizes a plant extract and a bionic vernix caseosa composition to simulate the lipid composition of vernix caseosa, and the formed skin care composition has the effects of anti-oxidation, moisturizing, promoting cell renewal, etc., and can form a protective layer on the skin surface, thereby enhancing the skin's defense ability. The present invention adds a protein composition to the bionic vernix caseosa skin care composition, which can not only improve the skin condition, but also promote the absorption of the remaining components in the skin composition, thereby enhancing the overall effect of the skin care composition. The skin care composition of the present invention does not contain irritating components, will not cause irritation and burden to the skin, and can be used to prepare children's skin care products.

Description

Technical Field

[0001] The invention belongs to the technical field of skin care products, and in particular relates to a children's bionic vernix caseosa skin care composition and a preparation method and application thereof. Background Art

[0002] Vernix caseosa is a mixture naturally secreted by the fetus in the mother's body, mainly composed of 80% water, 10% protein and 9% lipid. In the mother's body, vernix caseosa can protect the skin of the fetus from infiltration by amniotic fluid. After the fetus is born, vernix caseosa not only protects the skin, but also has an antibacterial effect. In addition, vernix caseosa has a repairing effect on the skin, helps newborns maintain skin water balance, maintain skin temperature, and help the skin maintain normal skin water activity. It is beneficial to damaged skin and dry skin, and is very helpful for the formation of skin barriers. And the moisturizing performance and skin repair ability of human vernix caseosa are most suitable for human skin. Although many skin care products in the prior art have moisturizing effects, the moisturizing degree is either too high or too low. Too high will cause greasy skin, and too low will cause dry skin. Only natural vernix caseosa is most suitable for human skin and has the most suitable moisturizing performance.

[0003] Although vernix has a good skin care effect, it is difficult to use in skin care products due to various problems. The main reasons are: 1. Vernix is ​​produced in the mother's body. When the fetus is full-term, the vernix will be naturally absorbed, and there will be no vernix on the skin of full-term babies; 2. Not all babies are born with vernix on their skin, and the vernix on the baby's skin is difficult to collect and provide for cosmetic use; 3. Vernix comes from the human body and contains a lot of protein, which poses the risk of immune rejection between different individuals and the spread of human diseases (such as AIDS, sexually transmitted diseases, skin diseases, etc.); 4. Social ethical disputes also make it impossible to use vernix derived from the human body in cosmetics.

[0004] The most basic function of cosmetics is to moisturize and maintain the skin barrier. At the same time, people are constantly developing various functional additives to make cosmetics achieve better skin care effects. However, some chemically synthesized raw materials are often not skin-friendly, which may cause safety risks and lead to allergies or irritation. How to obtain a bionic vernix caseosa skin care preparation that has the same excellent skin care effect as natural vernix caseosa, or even better and safer, is a hot topic for technicians in this field. Summary of the invention

[0005] In view of the above-mentioned prior art, the present invention provides a children's bionic vernix caseosa skin care composition and its preparation method and application, so as to obtain a bionic vernix caseosa skin care composition with similar efficacy to natural vernix caseosa, so as to solve the technical problem that the existing children's skin care products have poor skin care effects.

[0006] In order to achieve the above object, the technical solution adopted by the present invention is to provide a children's bionic vernix caseosa skin care composition, comprising the following components in parts by weight:

[0007] 70-80 parts of plant extract, 20-25 parts of bionic vernix composition, 8-12 parts of protein mixture, 5-10 parts of regulating agent and 90-110 parts of bionic fluid;

[0008] The plant extract is prepared by mixing gardenia extract, soapberry extract, tribulus terrestris extract, astragalus extract and grape seed extract in a mass ratio of 15-25:10-15:5-10:3-6:1-3;

[0009] The biomimetic fetal fat composition comprises the following components in parts by weight: 5 to 10 parts of squalane, 1 to 5 parts of cholesterol, 3 to 5 parts of ceramide AP and 3 to 4 parts of ceramide NP;

[0010] The protein mixture includes collagen, hydrolyzed keratin and hydrolyzed serum protein; the mass ratio of collagen, hydrolyzed keratin and hydrolyzed serum protein in the protein mixture is 10-20:5-15:2-5;

[0011] The regulating agent is prepared by mixing hydroxypinacolone retinoic acid ester, N-acetylglucosamine, sweet almond oil, lactobionic acid and cetyl alcohol in a mass ratio of 5-15:0.5-2:3-5:1-3;

[0012] The biomimetic fluid is an aqueous solution of sodium hyaluronate.

[0013] The beneficial effect of the above technical solution adopted by the present invention is that the present invention can well simulate the lipid composition of vernix caseosa by combining the plant extract and the bionic vernix caseosa composition with the protein mixture, so that the obtained bionic vernix caseosa can exert the same effect as vernix caseosa.

[0014] Gardenia extract in plant extracts can remove a variety of free radicals and has a good antioxidant effect. In addition, gardenia glycoside in gardenia extract has a bactericidal effect, which can play an antibacterial effect after use, and can soften the stratum corneum, so that the remaining components in the skin care composition are more easily absorbed by the skin. Soapberry extract can be used as a natural surfactant, which can gently remove dirt and oil on the skin surface, thereby maintaining the natural oil balance of the skin. Tribulus terrestris extract contains a variety of bioactive ingredients such as flavonoids and steroids. After being added to the skin care composition, it can give the skin care composition anti-inflammatory, antioxidant and cell regeneration effects, thereby promoting skin repair and regeneration. Astragalus extract has an excellent moisturizing effect, can effectively lock skin moisture, and keep the skin moisturized and soft; and astragalus extract is rich in amino acids and minerals, which can stimulate the skin to produce collagen, thereby increasing skin elasticity, making the skin more firm and elastic; in addition, astragalus extract can enhance cell activities such as skin cell metabolism, and it works together with gardenia extract to further promote the skin to absorb and utilize the remaining components. Grape seed extract is rich in ingredients such as proanthocyanidins. These active ingredients can not only act on the surface of the skin, inhibit the activity of tyrosinase, reduce the production and deposition of melanin, and thus help brighten the skin tone; moreover, these ingredients can also penetrate deep into the skin, act on the subcutaneous tissue, promote the production of collagen and enhance skin elasticity. This deep penetration can also promote the absorption of effective ingredients in skin care products, thereby improving the absorption and utilization rate of skin care products.

[0015] Squalane in the bionic vernix composition acts as an emollient and moisturizer, which can replenish the skin's natural sebum, form a natural protective film, effectively lock in moisture and prevent water loss. Cholesterol can enhance the skin's barrier function and improve the skin's defense ability. At the same time, cholesterol can also promote the absorption and utilization of other skin care ingredients. Ceramide AP can strengthen the skin's barrier function, reduce water evaporation and loss, and make the skin softer and smoother. Ceramide NP can continuously replenish moisture and nutrients to the skin.

[0016] The children's bionic vernix skin care composition of the present invention also includes a protein mixture, which includes collagen, hydrolyzed keratin and hydrolyzed serum protein; wherein collagen is an important component of the skin and has good moisturizing properties. It can lock moisture, provide lasting moisture and nourishment for the skin, and help maintain the elasticity and gloss of the skin; at the same time, collagen can promote the repair and regeneration of skin cells, and has a good repair effect on damaged skin tissue. In bionic vernix oil, this characteristic of collagen can accelerate the repair of the skin barrier and enhance the defense ability of the skin. Keratin is an important component of the stratum corneum of the skin, and hydrolyzed keratin is more easily absorbed by the skin, thereby strengthening the skin barrier function. In bionic vernix oil, the addition of hydrolyzed keratin can further improve the protective performance of the product and reduce the stimulation and damage of the external environment to the skin; hydrolyzed keratin can also promote the metabolism and renewal of keratinocytes, help remove aged keratinocytes, and make the skin smoother and more delicate. Serum protein is an important protein in the blood. After hydrolysis, it can release a variety of amino acids and nutrients, which can provide the skin with the necessary nutrients and energy and promote healthy growth and repair of the skin. Hydrolyzed serum protein also has good permeability, which can help other skin care ingredients better penetrate into the deep layers of the skin and improve the absorption rate and utilization rate of the product.

[0017] The children's bionic vernix skin care composition of the present invention also includes a regulator, which is composed of hydroxypinacolone retinoic acid ester, N-acetylglucosamine, sweet almond oil, lactobionic acid and cetyl alcohol. Among them, hydroxypinacolone retinoic acid ester and N-acetylglucosamine can regulate cell activity and sebum secretion, thereby promoting cells to absorb effective ingredients. Sweet almond oil and lactobionic acid have good permeability, can carry the remaining effective ingredients to penetrate into the skin, and then promote the absorption and utilization of effective ingredients in skin care products; and lactobionic acid can absorb moisture in the air, thereby regulating the moisturizing properties of the skin. Cetyl alcohol has excellent stability, can effectively avoid the loss and volatilization of effective ingredients, thereby ensuring the absorption of effective ingredients.

[0018] The various components in the present invention work synergistically with each other, so that the effective ingredients can be fully absorbed and utilized. While improving the absorption and utilization rate of the effective ingredients of the skin care products, it can effectively improve the skin condition, make the skin glow and keep it supple.

[0019] Based on the above technical solution, the present invention can also be improved as follows.

[0020] Furthermore, the plant extract is prepared by mixing gardenia extract, soapberry extract, tribulus terrestris extract, astragalus extract and grape seed extract in a mass ratio of 20:12:8:5:2; the regulating agent is prepared by mixing hydroxypinacolone retinoic acid ester, N-acetylglucosamine, almond oil, lactobionic acid and cetyl alcohol in a mass ratio of 10:1:4:2:2.

[0021] Further, the gardenia extract is prepared by the following steps:

[0022] S1: drying freshly picked gardenia flowers at 40-50°C until the moisture content is less than 5%, and then grinding the dried gardenia flowers into powder;

[0023] S2: Mix the gardenia powder and anhydrous ethanol in a solid-liquid ratio of 1 g:3-5 mL, stir at 30-40°C for 90-120 min, and then filter and collect the filtrate;

[0024] S3: Concentrate the filtrate until the volume no longer changes.

[0025] Further, the soapberry extract is prepared by the following steps:

[0026] S1: Dry the disease-free soapberry and then crush it into powder;

[0027] S2: Mix the soapberry powder with water at a solid-liquid ratio of 1 g: 3-5 mL, then heat the mixture to boiling for 5-10 min, and then filter while hot to collect the residue and filtrate respectively;

[0028] S3: Mix the filter residue with water at a solid-liquid ratio of 1 g: 3-5 mL, then heat the mixture to boiling for 10-20 min, filter while hot, and collect the filtrate;

[0029] S4: Combine the filtrates obtained from S2 and S3, cool to room temperature, add sodium chloride to the filtrate at a solid-liquid ratio of 1 g:10~15 mL, stir for 10~20 min, then filter, collect the filtrate and concentrate until the volume no longer changes.

[0030] Further, the Tribulus terrestris extract is prepared by the following steps:

[0031] S1: drying the Tribulus terrestris fruit and then crushing it into powder;

[0032] S2: Mix the Tribulus terrestris powder and anhydrous ethanol at a solid-liquid ratio of 1 g: 3-5 mL, stir at 30-40° C. for 90-120 min, and then filter to collect the filtrate;

[0033] S3: Concentrate the filtrate until the volume no longer changes.

[0034] Further, the astragalus extract is prepared by the following steps:

[0035] S1: Dry the Astragalus and crush it into powder;

[0036] S2: Place the Astragalus powder into a Soxhlet extractor and perform Soxhlet extraction using anhydrous ethanol as the extraction solution for 4 to 6 hours;

[0037] S3: Collect the extract and concentrate it until the volume no longer changes.

[0038] Further, grape seed extract is prepared by the following steps:

[0039] S1: Dry the grape seeds and then crush them into powder;

[0040] S2: Mix grape seed powder and water at a solid-liquid ratio of 1 g: 3-5 mL, then heat the mixture to boiling for 5-10 min, and then filter while hot to collect the residue and filtrate respectively;

[0041] S3: Mix the filter residue with water at a solid-liquid ratio of 1 g: 3-5 mL, then heat the mixture to boiling for 10-20 min, filter while hot, and collect the filtrate;

[0042] S4: Combine the filtrates obtained from S2 and S3, and then concentrate until the volume no longer changes to obtain S4.

[0043] Further, the biomimetic fetal fat composition is obtained by mixing the following components in parts by weight: 5 parts of squalane, 1.5 parts of cholesterol, 3 parts of ceramide AP and 3 parts of ceramide NP;

[0044] Alternatively, the biomimetic fetal fat composition is obtained by mixing the following components in parts by weight: 10 parts of squalane, 2 parts of cholesterol, 5 parts of ceramide AP and 4 parts of ceramide NP.

[0045] The present invention also discloses a method for preparing the children's bionic vernix caseosa skin care composition, comprising the following steps:

[0046] S1: adding the plant extract and squalane in the biomimetic vernix composition into a liquid preparation tank, stirring at 20-40° C. at a rotation speed of 1400 rpm for 10 min, then adding cholesterol in the biomimetic vernix composition, and continuing stirring for 2 h to obtain solution 1;

[0047] S2: adding ceramide AP and ceramide NP in the bionic fetal fat composition to the bionic solution, stirring at 80-90°C for 2h to obtain solution 2;

[0048] S3: Mix solution 1 and solution 2, then add the protein mixture and the regulator into the mixed solution, stir for 30 minutes, and obtain the stock solution;

[0049] S4: The stock solution is filtered through a 0.45 μm PP filter element and a 0.2 μm PVDF sterilization filter element in sequence and then sealed in a low-density polyethylene plastic bottle.

[0050] The present invention also discloses the application of the children's bionic vernix caseosa skin care composition, specifically using the children's bionic vernix caseosa skin care composition in the preparation of children's skin care products.

[0051] The beneficial effects of the present invention are:

[0052] 1. The present invention utilizes plant extracts and bionic vernix caseosa composition to simulate the lipid composition of vernix caseosa. The formed skin care composition has the effects of anti-oxidation, moisturizing, promoting cell renewal, etc., and can form a protective layer on the skin surface, thereby enhancing the skin's defense ability.

[0053] 2. The present invention adds a protein composition to the bionic vernix caseosa skin care composition, which can not only improve the skin condition, but also promote the absorption of other components in the skin composition, thereby enhancing the overall effect of the skin care composition.

[0054] 3. The skin care composition of the present invention does not contain any irritating components, will not cause irritation or burden to the skin, and can be used to prepare children's skin care products. DETAILED DESCRIPTION

[0055] The children's bionic vernix skin care composition of the present invention comprises components such as plant extracts, bionic vernix composition, protein mixture, regulator and bionic fluid. Among them, the plant extract is a mixture of gardenia extract, soapberry extract, Tribulus terrestris extract, astragalus extract and grape seed extract. The plant extract used can be a commercial product or self-extracted. If self-extracted, the gardenia extract is prepared by the following steps:

[0056] S1: drying freshly picked gardenia flowers at 45°C until the moisture content is less than 5%, and then grinding the dried gardenia flowers into powder with a particle size not exceeding 50 mesh;

[0057] S2: Mix gardenia powder and anhydrous ethanol at a solid-liquid ratio of 1 g:4 mL, stir at 35°C for 100 min, then filter and collect the filtrate;

[0058] S3: Concentrate the filtrate until the volume no longer changes.

[0059] The soapberry extract is prepared by the following steps:

[0060] S1: Dry the disease-free soapberries (water content less than 5%) and then crush them into powder with a particle size not exceeding 50 mesh;

[0061] S2: Mix the soapberry powder with water at a solid-liquid ratio of 1 g:4 mL, then heat the mixture to boiling for 8 min, and then filter while hot to collect the residue and filtrate respectively;

[0062] S3: Mix the filter residue with water at a solid-liquid ratio of 1 g:4 mL, then heat the mixture to boiling for 15 min, filter while hot, and collect the filtrate;

[0063] S4: Combine the filtrates obtained from S2 and S3, cool to room temperature, add sodium chloride to the filtrate at a solid-liquid ratio of 1 g:12 mL, stir for 15 min, then filter, collect the filtrate and concentrate until the volume no longer changes.

[0064] The Tribulus terrestris extract is prepared by the following steps:

[0065] S1: drying the Tribulus terrestris fruit (water content less than 5%), and then crushing it into powder with a particle size not exceeding 50 mesh;

[0066] S2: Mix the Tribulus terrestris powder and anhydrous ethanol at a solid-liquid ratio of 1 g:4 mL, and stir at 35° C. for 120 min; then filter and collect the filtrate;

[0067] S3: Concentrate the filtrate until the volume no longer changes.

[0068] Astragalus extract is prepared by the following steps:

[0069] S1: Dry the astragalus root (water content less than 5%) and grind it into powder with a particle size not exceeding 50 mesh;

[0070] S2: The astragalus powder was placed in a Soxhlet extractor and subjected to Soxhlet extraction using anhydrous ethanol as the extraction solution for 5 h;

[0071] S3: Collect the extract and concentrate it until the volume no longer changes.

[0072] Grape seed extract is prepared by the following steps:

[0073] S1: Dry the grape seeds (water content less than 5%), and then grind them into powder with a particle size not exceeding 50 mesh;

[0074] S2: Mix grape seed powder and water at a solid-liquid ratio of 1 g:4 mL, then heat the mixture to boiling for 8 min, and then filter while hot to collect the residue and filtrate respectively;

[0075] S3: Mix the filter residue with water at a solid-liquid ratio of 1 g:4 mL, then heat the mixture to boiling for 15 min, filter while hot, and collect the filtrate;

[0076] S4: Combine the filtrates obtained from S2 and S3, and then concentrate until the volume no longer changes to obtain S4.

[0077] The components in the bionic fetal fat composition, the protein mixture and the regulator are all commercially available products.

[0078] The specific implementation modes of the present invention are described in detail below with reference to the embodiments.

[0079] Example 1

[0080] A children's bionic vernix caseosa skin care composition comprises the following components in parts by weight:

[0081] 75 parts of plant extract, 20 parts of bionic vernix caseosa composition, 10 parts of protein mixture, 8 parts of regulator and 100 parts of bionic fluid; wherein the bionic vernix caseosa composition is obtained by mixing the following components in parts by mass:

[0082] 5 parts of squalane, 1.5 parts of cholesterol, 3 parts of ceramide AP and 3 parts of ceramide NP;

[0083] The plant extract is prepared by mixing Gardenia jasminoides extract, Sapindus mukorossi extract, Tribulus terrestris extract, Astragalus membranaceus extract and Grape seed extract in a mass ratio of 20:12:8:5:2; the plant extracts used in this embodiment are all extracted by themselves, and the extraction method is as described above;

[0084] The protein mixture was composed of collagen (type III), hydrolyzed keratin, and hydrolyzed serum albumin in a mass ratio of 15:10:3;

[0085] The regulator is prepared by mixing hydroxypinacolone retinoic acid ester, N-acetylglucosamine, sweet almond oil, lactobionic acid and cetyl alcohol in a mass ratio of 10:1:4:2:2;

[0086] The bionic fluid is a sodium hyaluronate aqueous solution with a concentration of 40wt%.

[0087] The children's bionic vernix caseosa skin care composition in this embodiment is prepared by the following steps:

[0088] S1: adding the plant extract and squalane in the biomimetic vernix composition into a liquid preparation tank, stirring at 30° C. at a rotation speed of 1400 rpm for 10 min, then adding cholesterol in the biomimetic vernix composition, and continuing stirring for 2 h to obtain solution 1;

[0089] S2: adding ceramide AP and ceramide NP in the biomimetic fetal fat composition to the biomimetic liquid, stirring at 85° C. for 2 h, to obtain solution 2;

[0090] S3: Mix solution 1 and solution 2, then add the protein mixture and the regulator into the mixed solution, stir for 30 minutes, and obtain the stock solution;

[0091] S4: The stock solution is filtered through a 0.45 μm PP filter element and a 0.2 μm PVDF sterilization filter element in sequence and then sealed in a low-density polyethylene plastic bottle.

[0092] Example 2

[0093] A children's bionic vernix caseosa skin care composition comprises the following components in parts by weight:

[0094] 70 parts of plant extract, 25 parts of bionic vernix caseosa composition, 8 parts of protein mixture, 5 parts of regulator and 110 parts of bionic fluid; wherein the bionic vernix caseosa composition comprises the following components in parts by weight:

[0095] 10 parts of squalane, 2 parts of cholesterol, 5 parts of ceramide AP and 4 parts of ceramide NP.

[0096] The plant extract is prepared by mixing Gardenia jasminoides extract, Sapindus mukorossi extract, Tribulus terrestris extract, Astragalus membranaceus extract and Grape seed extract in a mass ratio of 15:15:5:6:1; the plant extracts used in this embodiment are all extracted by themselves, and the extraction method is as described above;

[0097] The protein mixture was composed of collagen (type III), hydrolyzed keratin, and hydrolyzed serum albumin in a mass ratio of 10:15:2;

[0098] The regulator is prepared by mixing hydroxypinacolone retinoic acid ester, N-acetylglucosamine, sweet almond oil, lactobionic acid and cetyl alcohol in a mass ratio of 5:2:3:3:1;

[0099] The bionic fluid is a sodium hyaluronate aqueous solution with a concentration of 30wt%.

[0100] The children's bionic vernix caseosa skin care composition in this embodiment is prepared by the following steps:

[0101] S1: adding the plant extract and squalane in the biomimetic vernix composition into a liquid preparation tank, stirring at 1400 rpm for 10 min at 20° C., then adding cholesterol in the biomimetic vernix composition, and continuing stirring for 2 h to obtain solution 1;

[0102] S2: adding ceramide AP and ceramide NP in the biomimetic fetal fat composition to the biomimetic liquid, stirring at 80° C. for 2 h, to obtain solution 2;

[0103] S3: Mix solution 1 and solution 2, then add the protein mixture and the regulator into the mixed solution, stir for 30 minutes, and obtain the stock solution;

[0104] S4: The stock solution is filtered through a 0.45 μm PP filter element and a 0.2 μm PVDF sterilization filter element in sequence and then sealed in a low-density polyethylene plastic bottle.

[0105] Example 3

[0106] A children's bionic vernix caseosa skin care composition comprises the following components in parts by weight:

[0107] 80 parts of plant extract, 20 parts of bionic vernix caseosa composition, 12 parts of protein mixture, 10 parts of regulator and 90 parts of bionic fluid; wherein the bionic vernix caseosa composition comprises the following components in parts by weight:

[0108] 8 parts of squalane, 2 parts of cholesterol, 4.5 parts of ceramide AP and 3.5 parts of ceramide NP;

[0109] The plant extract is prepared by mixing Gardenia jasminoides extract, Sapindus mukorossi extract, Tribulus terrestris extract, Astragalus membranaceus extract and Grape seed extract in a mass ratio of 25:10:10:3:3; the plant extracts used in this embodiment are all extracted by themselves, and the extraction method is as described above;

[0110] The protein mixture was composed of collagen (type III), hydrolyzed keratin, and hydrolyzed serum albumin in a mass ratio of 20:5:5;

[0111] The regulator is prepared by mixing hydroxypinacolone retinoic acid ester, N-acetylglucosamine, sweet almond oil, lactobionic acid and cetyl alcohol in a mass ratio of 5:2:3:3:1;

[0112] The bionic fluid is a sodium hyaluronate aqueous solution with a concentration of 50wt%.

[0113] The children's bionic vernix caseosa skin care composition in this embodiment is prepared by the following steps:

[0114] S1: adding the plant extract and squalane in the biomimetic vernix composition into a liquid preparation tank, stirring at 40° C. at a rotation speed of 1400 rpm for 10 min, then adding cholesterol in the biomimetic vernix composition, and continuing stirring for 2 h to obtain solution 1;

[0115] S2: adding ceramide AP and ceramide NP in the biomimetic fetal fat composition to the biomimetic liquid, stirring at 90° C. for 2 h, to obtain solution 2;

[0116] S3: Mix solution 1 and solution 2, then add the protein mixture and the regulator into the mixed solution, stir for 30 minutes, and obtain the stock solution;

[0117] S4: The stock solution is filtered through a 0.45 μm PP filter element and a 0.2 μm PVDF sterilization filter element in sequence and then sealed in a low-density polyethylene plastic bottle.

[0118] Comparative Example 1

[0119] A children's bionic vernix caseosa skin care composition comprises the following components in parts by weight:

[0120] 80 parts of plant extract, 12 parts of protein mixture, 10 parts of regulator and 110 parts of biomimetic fluid; wherein,

[0121] The plant extract is prepared by mixing Gardenia jasminoides extract, Sapindus mukorossi extract, Tribulus terrestris extract, Astragalus membranaceus extract and Grape seed extract in a mass ratio of 25:10:10:3:3; the plant extracts used in this embodiment are all extracted by themselves, and the extraction method is as described above;

[0122] The protein mixture was composed of collagen (type III), hydrolyzed keratin, and hydrolyzed serum albumin in a mass ratio of 20:5:5;

[0123] The regulator is prepared by mixing hydroxypinacolone retinoic acid ester, N-acetylglucosamine, sweet almond oil, lactobionic acid and cetyl alcohol in a mass ratio of 5:2:3:3:1;

[0124] The bionic fluid is a sodium hyaluronate aqueous solution with a concentration of 50wt%.

[0125] The children's bionic vernix caseosa skin care composition in this comparative example is prepared by the following steps:

[0126] S1: adding the formulated amount of plant extract to the bionic liquid, stirring at 1400 rpm for 10 min at 40°C, and then naturally cooling to room temperature to obtain an emulsion;

[0127] S2: Add the formulated amount of protein mixture and regulator into the emulsion and stir for 30 minutes to obtain the stock solution;

[0128] S3: The stock solution is filtered through a 0.45 μm PP filter element and a 0.2 μm PVDF sterilization filter element in sequence and then sealed in a low-density polyethylene plastic bottle.

[0129] Comparative Example 2

[0130] A children's bionic vernix caseosa skin care composition comprises the following components in parts by weight:

[0131] 20 parts of bionic fetal fat composition, 12 parts of protein mixture, 10 parts of regulator and 170 parts of bionic liquid; wherein the bionic fetal fat composition includes the following components in parts by weight:

[0132] 8 parts of squalane, 2 parts of cholesterol, 4.5 parts of ceramide AP and 3.5 parts of ceramide NP;

[0133] The protein mixture was composed of collagen (type III), hydrolyzed keratin, and hydrolyzed serum albumin in a mass ratio of 20:5:5;

[0134] The regulator is prepared by mixing hydroxypinacolone retinoic acid ester, N-acetylglucosamine, sweet almond oil, lactobionic acid and cetyl alcohol in a mass ratio of 5:2:3:3:1;

[0135] The bionic fluid is a sodium hyaluronate aqueous solution with a concentration of 50wt%.

[0136] The children's bionic vernix caseosa skin care composition in this comparative example is prepared by the following steps:

[0137] S1: adding the formulated amount of the children's bionic fetal fat composition to the bionic liquid, stirring at 40° C. and 1400 rpm for 10 min, and then naturally cooling to room temperature to obtain an emulsion;

[0138] S2: Add the formulated amount of protein mixture and regulator into the emulsion and stir for 30 minutes to obtain the stock solution;

[0139] S3: The stock solution is filtered through a 0.45 μm PP filter element and a 0.2 μm PVDF sterilization filter element in sequence and then sealed in a low-density polyethylene plastic bottle.

[0140] Comparative Example 3

[0141] Compared with Example 3, the gardenia extract in the plant extract was replaced by an equal amount of sodium hyaluronate aqueous solution, and the remaining operations were the same as in Example 3.

[0142] Comparative Example 4

[0143] Compared with Example 3, the astragalus extract in the plant extract was replaced by an equal amount of sodium hyaluronate aqueous solution, and the remaining operations were the same as those in Example 3.

[0144] Comparative Example 5

[0145] Compared with Example 3, the grape seed extract in the plant extract was replaced by an equal amount of sodium hyaluronate aqueous solution, and the remaining operations were the same as those in Example 3.

[0146] Comparative Example 6

[0147] Compared with Example 3, the gardenia extract and grape seed extract in the plant extract were replaced by an equal amount of sodium hyaluronate aqueous solution, and the remaining operations were the same as in Example 3.

[0148] Comparative Example 7

[0149] A children's bionic vernix caseosa skin care composition comprises the following components in parts by weight:

[0150] 80 parts of plant extract, 20 parts of bionic fetal fat composition, 10 parts of regulating agent and 102 parts of bionic fluid; wherein the bionic fetal fat composition comprises the following components in parts by weight:

[0151] 8 parts of squalane, 2 parts of cholesterol, 4.5 parts of ceramide AP and 3.5 parts of ceramide NP;

[0152] The plant extract is prepared by mixing Gardenia jasminoides extract, Sapindus mukorossi extract, Tribulus terrestris extract, Astragalus membranaceus extract and Grape seed extract in a mass ratio of 25:10:10:3:3; the plant extracts used in this embodiment are all extracted by themselves, and the extraction method is as described above;

[0153] The regulator is prepared by mixing hydroxypinacolone retinoic acid ester, N-acetylglucosamine, sweet almond oil, lactobionic acid and cetyl alcohol in a mass ratio of 5:2:3:3:1;

[0154] The bionic fluid is a sodium hyaluronate aqueous solution with a concentration of 50wt%.

[0155] The children's bionic vernix caseosa skin care composition in this comparative example is prepared by the following steps:

[0156] S1: adding the plant extract and squalane in the biomimetic vernix composition into a liquid preparation tank, stirring at 40° C. at a rotation speed of 1400 rpm for 10 min, then adding cholesterol in the biomimetic vernix composition, and continuing stirring for 2 h to obtain solution 1;

[0157] S2: adding ceramide AP and ceramide NP in the biomimetic fetal fat composition to the biomimetic liquid, stirring at 90° C. for 2 h, to obtain solution 2;

[0158] S3: Mix solution 1 and solution 2, then add the regulator into the mixed solution and stir for 30 minutes to obtain the stock solution;

[0159] S4: The stock solution is filtered through a 0.45 μm PP filter element and a 0.2 μm PVDF sterilization filter element in sequence and then sealed in a low-density polyethylene plastic bottle.

[0160] Comparative Example 8

[0161] A children's bionic vernix caseosa skin care composition comprises the following components in parts by weight:

[0162] 80 parts of plant extract, 20 parts of bionic vernix caseosa composition, 12 parts of protein mixture and 100 parts of bionic liquid; wherein the bionic vernix caseosa composition comprises the following components in parts by weight:

[0163] 8 parts of squalane, 2 parts of cholesterol, 4.5 parts of ceramide AP and 3.5 parts of ceramide NP;

[0164] The plant extract is prepared by mixing Gardenia jasminoides extract, Sapindus mukorossi extract, Tribulus terrestris extract, Astragalus membranaceus extract and Grape seed extract in a mass ratio of 25:10:10:3:3; the plant extracts used in this embodiment are all extracted by themselves, and the extraction method is as described above;

[0165] The protein mixture was composed of collagen (type III), hydrolyzed keratin, and hydrolyzed serum albumin in a mass ratio of 20:5:5;

[0166] The bionic fluid is a sodium hyaluronate aqueous solution with a concentration of 50wt%.

[0167] The children's bionic vernix caseosa skin care composition in this comparative example is prepared by the following steps:

[0168] S1: adding the plant extract and squalane in the biomimetic vernix composition into a liquid preparation tank, stirring at 40° C. at a rotation speed of 1400 rpm for 10 min, then adding cholesterol in the biomimetic vernix composition, and continuing stirring for 2 h to obtain solution 1;

[0169] S2: adding ceramide AP and ceramide NP in the biomimetic fetal fat composition to the biomimetic liquid, stirring at 90° C. for 2 h, to obtain solution 2;

[0170] S3: Mix solution 1 and solution 2, then add the protein mixture to the mixed solution and stir for 30 minutes to obtain the stock solution;

[0171] S4: The stock solution is filtered through a 0.45 μm PP filter element and a 0.2 μm PVDF sterilization filter element in sequence and then sealed in a low-density polyethylene plastic bottle.

[0172] Comparative Example 9

[0173] Compared with Example 3, the hydroxypinacolone retinoic acid ester and N-acetylglucosamine in the regulating agent were replaced by an equal amount of sodium hyaluronate aqueous solution, and the remaining operations were the same as in Example 3.

[0174] Comparative Example 10

[0175] Compared with Example 3, the sweet almond oil and lactobionic acid in the regulating agent were replaced by an equal amount of sodium hyaluronate aqueous solution, and the remaining operations were the same as in Example 3.

[0176] Comparative Example 11

[0177] With the consent of the parents of the volunteer infants, human vernix caseosa was collected from the skin of newborn infants, and freeze-dried to remove the water and volatile substances in the vernix caseosa.

[0178] Experimental example

[0179] 1. Evaluation of the moisturizing efficacy of the bionic vernix caseosa skin care composition for children

[0180] 280 healthy subjects aged 5 to 15 were selected and divided into 14 groups, 20 in each group (10 males and 10 females). All subjects had no history of skin or systemic diseases, and there was no abnormality in the test site. The moisturizing effect of the children's bionic vernix skin care composition in the above embodiments and comparative examples was detected by the method described in "QB / T 4256-2011 Guidelines for Evaluation of Moisturizing Efficacy of Cosmetics". The specific method is: divide multiple 3cm*3cm test areas on the inner side of the arm, use a moisture tester to measure the skin moisture content of each area before applying the children's bionic vernix skin care composition, and 0.5h, 1h, 2h and 4h after applying the children's bionic vernix skin care composition, and calculate the increment of the skin moisture content in the test area. The calculation formula is as follows:

[0181]

[0182] Among them, H c H0 is the water content measured after applying the children's bionic vernix caseosa skin care composition, and H1 is the water content measured before applying the children's bionic vernix caseosa skin care composition. The results are shown in Table 1 (the average values ​​are listed in the table).

[0183] Table 1 Increment of skin moisture content after using the children's bionic vernix caseosa skin care composition (%)

[0184]

[0185] It can be seen from Table 1 that the children's bionic vernix caseosa skin care composition (Examples 1 to 3) of the present invention has an excellent moisturizing effect and can effectively maintain the moisture of children's skin.

[0186] Compared with Example 3, in Comparative Example 1, the skin care composition lacks the bionic vernix caseosa composition. After using the skin care composition, the water content of the children's skin does not increase significantly, indicating that the bionic vernix caseosa composition has a significant effect in moisturizing.

[0187] Compared with Example 3, in Comparative Example 2, the skin care composition lacks plant extracts. After using the skin care composition, the water content of the children's skin is not significantly increased, indicating that the plant extracts have a positive effect in promoting the skin's absorption and utilization rate of effective ingredients to keep the skin hydrated.

[0188] Compared with Example 3, the skin care composition of Comparative Example 3 lacks gardenia extract. Compared with Comparative Example 2, the moisture content is significantly improved, but compared with Example 3, there is still a large difference, indicating that gardenia extract can play a good role in promoting the absorption of effective ingredients, thereby enabling the skin care composition to play a good moisturizing effect.

[0189] Compared with Example 3, Comparative Example 4 lacks the astragalus extract in the skin care composition. Similarly, compared with Comparative Example 2, the moisture content is significantly improved, but compared with Example 3, there is still a large difference, indicating that the astragalus extract not only has a good moisturizing effect, but also can play a certain absorption-promoting effect, so that the skin care composition can play a good moisturizing effect.

[0190] Compared with Example 3, Comparative Example 5 lacks grape seed extract in the skin care composition. Similarly, compared with Comparative Example 2, the moisture content is significantly improved, but compared with Example 3, there is still a large difference, indicating that the grape seed extract can play a good role in promoting the absorption of effective ingredients, thereby enabling the skin care composition to play a good moisturizing effect.

[0191] Compared with Example 3, the skin care composition of Comparative Example 6 lacks gardenia extract and grape seed extract. Compared with Comparative Examples 4 and 5, the moisture content is significantly reduced, indicating that gardenia extract and grape seed extract have a synergistic effect. The combined effect of the two can effectively promote the absorption of effective ingredients, thereby enabling the skin care composition to exert a good moisturizing effect.

[0192] Compared with Example 3, in Comparative Example 7, the skin care composition lacks the protein mixture. After using the skin care composition, the water content of the skin is not significantly increased, indicating that the protein mixture has a positive effect on improving the moisturizing performance of the skin care composition.

[0193] Compared with Example 3, Comparative Example 8 lacks a regulating agent in the skin care composition. After using the skin care composition, although the water content of the skin is improved, there is still a difference compared with the example; this shows that the regulating agent has a certain regulating effect on the performance of the skin care composition and can affect the moisturizing effect of the skin care composition.

[0194] Compared with Example 3, Comparative Example 9 lacks hydroxypinacolone retinoic acid ester and N-acetylglucosamine in the skin care composition. Compared with Comparative Example 8, the moisture content is improved, but compared with Example 3, there is still a certain gap, indicating that the combined effect of hydroxypinacolone retinoic acid ester and N-acetylglucosamine can play an important role in improving the moisturizing effect of the skin care composition.

[0195] Compared with Example 3, Comparative Example 10 lacks sweet almond oil and lactobionic acid in the skin care composition. Similarly, compared with Comparative Example 8, the moisture content is improved, but compared with Example 3, there is still a certain gap, indicating that the combined effect of sweet almond oil and lactobionic acid can play an important role in improving the moisturizing effect of the skin care composition.

[0196] Comparative Example 11 is human vernix caseosa, and the effect it produces is equivalent to that of Examples 1 to 3, indicating that the children's bionic vernix caseosa skin care composition of the present invention has similar effects to human vernix caseosa, and can be used as a substitute for human vernix caseosa.

[0197] 2. Evaluation of the soothing efficacy of the bionic vernix caseosa skin care composition for children

[0198] In addition, 280 healthy subjects aged 5 to 15 years were selected and divided into 14 groups, with 20 subjects in each group (10 males and 10 females). All subjects had no history of skin or systemic diseases and had a transepidermal water loss of ≥15 g / m 2 h. The children's bionic vernix skin care composition in the embodiment and the comparative example was applied to the skin of the face, neck, hands and other parts of the body, and gently massaged until absorbed. The skin hemoglobin Erythema value above the nasolabial groove and below the eyes of the subjects was tested using a skin hemoglobin test probe Mexameter®MX18 (CK, Germany) before applying the children's bionic vernix skin care composition, 14 days after applying, and 28 days after applying. The elasticity test probe Cutometerr®2mm MPA 580 (CK, Germany) was used to test the skin elasticity R2 value and skin firmness F4 of the corners of the eyes of the subjects. The results are shown in Tables 2-3.

[0199] Table 2 Skin hemoglobin Erythema value after using children's bionic vernix caseosa skin care composition

[0200]

[0201] Table 3 Skin elasticity R2 (%) after using the children's bionic vernix caseosa skin care composition

[0202]

[0203] It can be seen from Tables 2-3 that the children's bionic vernix caseosa skin care composition (Examples 1-3) of the present invention has excellent skin soothing effect and can effectively improve skin smoothness and elasticity.

[0204] Compared with Example 3, the skin care composition of Comparative Example 1 lacks the bionic vernix caseosa composition. After using the skin care composition, the decrease in pigment value and increase in elasticity of children's skin are not obvious, indicating that the bionic vernix caseosa composition has a positive effect on improving the smoothness and elasticity of children's skin.

[0205] Compared with Example 3, in Comparative Example 2, the skin care composition lacks plant extracts. After using the skin care composition, the decrease in pigmentation value and increase in elasticity of children's skin are not obvious, indicating that plant extracts also have a positive effect in improving the smoothness and elasticity of children's skin.

[0206] Compared with Example 3, the skin care composition of Comparative Example 3 lacks gardenia extract. Compared with Comparative Example 2, the pigment value is reduced and the elasticity is increased, but compared with Example 3, there is still a large difference, indicating that gardenia extract can not only promote the moisturizing effect of the skin care composition, but also plays an important role in reducing pigment value and improving skin elasticity.

[0207] Compared with Example 3, Comparative Example 4 lacks Astragalus extract in the skin care composition. Similarly, compared with Comparative Example 2, the pigment value is reduced and the elasticity is increased, but compared with Example 3, there is still a large difference, indicating that the Astragalus extract can not only promote the moisturizing effect of the skin care composition, but also plays an important role in reducing the pigment value and improving skin elasticity.

[0208] Compared with Example 3, Comparative Example 5 lacks grape seed extract in the skin care composition. Similarly, compared with Comparative Example 2, the pigment value is reduced and the elasticity is increased, but compared with Example 3, there is still a large difference, indicating that grape seed extract can not only promote the moisturizing effect of the skin care composition, but also plays an important role in reducing pigment values ​​and improving skin elasticity.

[0209] Compared with Example 3, in Comparative Example 6, the skin care composition lacks gardenia extract and grape seed extract. Compared with Comparative Examples 4 and 5, the pigment value increases and the elasticity decreases, indicating that gardenia extract and grape seed extract have a synergistic effect, and the combined effect of the two can bring better skin soothing effect.

[0210] Compared with Example 3, in Comparative Example 7, the skin care composition lacks the protein mixture. After using the skin care composition, the decrease in pigment value and increase in elasticity of children's skin are not obvious, indicating that the protein mixture also has a positive effect in improving the smoothness and elasticity of children's skin.

[0211] Compared with Example 3, Comparative Example 8 lacks a regulating agent in the skin care composition. After using the skin care composition, the pigment value of the children's skin decreases and the elasticity increases, but there are still differences compared with the examples; this shows that the regulating agent has a certain regulating effect on the performance of the skin care composition and can affect the skin soothing effect of the skin care composition.

[0212] Compared with Example 3, Comparative Example 9 lacks hydroxypinacolone retinoic acid ester and N-acetylglucosamine in the skin care composition. Compared with Comparative Example 8, the pigment value is reduced and the elasticity is increased, but compared with Example 3, there is still a certain gap, indicating that the combined effect of hydroxypinacolone retinoic acid ester and N-acetylglucosamine can bring better skin soothing effect.

[0213] Compared with Example 3, Comparative Example 10 lacks sweet almond oil and lactobionic acid in the skin care composition. Similarly, compared with Comparative Example 8, the pigment value is reduced and the elasticity is increased, but compared with Example 3, there is still a certain gap, indicating that the combined effect of sweet almond oil and lactobionic acid can bring better skin soothing effect.

[0214] Comparative Example 11 is human vernix caseosa, and the effect it produces is equivalent to that of Examples 1 to 3, indicating that the children's bionic vernix caseosa skin care composition of the present invention has similar effects to human vernix caseosa, and can be used as a substitute for human vernix caseosa.

[0215] Although the specific implementation of the present invention is described in detail in conjunction with the embodiments, it should not be understood as limiting the scope of protection of this patent. Within the scope described in the claims, various modifications and variations that can be made by those skilled in the art without creative work still fall within the scope of protection of this patent.

Claims

1. A children's bionic vernix caseosa skin care composition, characterized in that: The composition comprises the following components in parts by weight: 70-80 parts of plant extract, 20-25 parts of bionic vernix composition, 8-12 parts of protein mixture, 5-10 parts of regulating agent and 90-110 parts of bionic fluid; The plant extract is prepared by mixing gardenia extract, soapberry extract, tribulus terrestris extract, astragalus extract and grape seed extract in a mass ratio of 15-25:10-15:5-10:3-6:1-3; The bionic fetal fat composition comprises the following components in parts by weight: 5 to 10 parts of squalane, 1 to 5 parts of cholesterol, 3 to 5 parts of ceramide AP and 3 to 4 parts of ceramide NP; The protein mixture comprises collagen, hydrolyzed keratin and hydrolyzed serum protein; the mass ratio of collagen, hydrolyzed keratin and hydrolyzed serum protein in the protein mixture is 10-20:5-15:2-5; The regulating agent is prepared by mixing hydroxypinacolone retinoic acid ester, N-acetylglucosamine, sweet almond oil, lactobionic acid and cetyl alcohol in a mass ratio of 5-15:0.5-2:3-5:1-3:1-3; The bionic fluid is a sodium hyaluronate aqueous solution.

2. The children's bionic vernix caseosa skin care composition according to claim 1, characterized in that: The plant extract is prepared by mixing gardenia extract, soapberry extract, tribulus terrestris extract, astragalus extract and grape seed extract in a mass ratio of 20:12:8:5:2; the regulating agent is prepared by mixing hydroxypinacolone retinoic acid ester, N-acetylglucosamine, sweet almond oil, lactobionic acid and cetyl alcohol in a mass ratio of 10:1:4:2:

2.

3. The children's bionic vernix caseosa skin care composition according to claim 1 or 2, characterized in that: The gardenia extract is prepared by the following steps: S1: drying freshly picked gardenia flowers at 40-50°C until the moisture content is less than 5%, and then grinding the dried gardenia flowers into powder; S2: Mix the gardenia powder and anhydrous ethanol in a solid-liquid ratio of 1 g:3-5 mL, stir at 30-40°C for 90-120 min, and then filter and collect the filtrate; S3: Concentrate the filtrate until the volume no longer changes.

4. The children's bionic vernix caseosa skin care composition according to claim 1 or 2, characterized in that: The soapberry extract is prepared by the following steps: S1: Dry the disease-free soapberry and then crush it into powder; S2: Mix the soapberry powder with water at a solid-liquid ratio of 1 g: 3-5 mL, then heat the mixture to boiling for 5-10 min, and then filter while hot to collect the residue and filtrate respectively; S3: Mix the filter residue with water at a solid-liquid ratio of 1 g: 3-5 mL, then heat the mixture to boiling for 10-20 min, filter while hot, and collect the filtrate; S4: Combine the filtrates obtained from S2 and S3, cool to room temperature, add sodium chloride to the filtrate at a solid-liquid ratio of 1 g:10~15 mL, stir for 10~20 min, then filter, collect the filtrate and concentrate until the volume no longer changes.

5. The children's bionic vernix caseosa skin care composition according to claim 1 or 2, characterized in that: The Tribulus terrestris extract is prepared by the following steps: S1: drying the Tribulus terrestris fruit and then crushing it into powder; S2: Mix the Tribulus terrestris powder and anhydrous ethanol at a solid-liquid ratio of 1 g: 3-5 mL, stir at 30-40° C. for 90-120 min, and then filter to collect the filtrate; S3: Concentrate the filtrate until the volume no longer changes.

6. The children's bionic vernix caseosa skin care composition according to claim 1 or 2, characterized in that: The astragalus extract is prepared by the following steps: S1: Dry the Astragalus and crush it into powder; S2: Place the Astragalus powder into a Soxhlet extractor and perform Soxhlet extraction using anhydrous ethanol as the extraction solution for 4 to 6 hours; S3: Collect the extract and concentrate it until the volume no longer changes.

7. The children's bionic vernix caseosa skin care composition according to claim 1 or 2, characterized in that: The grape seed extract is prepared by the following steps: S1: Dry the grape seeds and then crush them into powder; S2: Mix grape seed powder and water at a solid-liquid ratio of 1 g: 3-5 mL, then heat the mixture to boiling for 5-10 min, and then filter while hot to collect the residue and filtrate respectively; S3: Mix the filter residue with water at a solid-liquid ratio of 1 g: 3-5 mL, then heat the mixture to boiling for 10-20 min, filter while hot, and collect the filtrate; S4: Combine the filtrates obtained from S2 and S3, and then concentrate until the volume no longer changes to obtain S4.

8. The children's bionic vernix caseosa skin care composition according to claim 1, characterized in that: The bionic fetal fat composition is obtained by mixing the following components in parts by weight: 5 parts of squalane, 1.5 parts of cholesterol, 3 parts of ceramide AP and 3 parts of ceramide NP; Alternatively, the biomimetic vernix caseosa composition is obtained by mixing the following components in parts by weight: 10 parts of squalane, 2 parts of cholesterol, 5 parts of ceramide AP and 4 parts of ceramide NP.

9. The method for preparing the children's bionic vernix caseosa skin care composition according to any one of claims 1 to 8, characterized in that: The following steps are involved: S1: adding the plant extract and squalane in the biomimetic vernix composition into a liquid preparation tank, stirring at 20-40° C. at a rotation speed of 1400 rpm for 10 min, then adding cholesterol in the biomimetic vernix composition, and continuing stirring for 2 h to obtain solution 1; S2: adding ceramide AP and ceramide NP in the bionic fetal fat composition to the bionic solution, stirring at 80-90°C for 2h to obtain solution 2; S3: Mix solution 1 and solution 2, then add the protein mixture and the regulator into the mixed solution, stir for 30 minutes, and obtain the stock solution; S4: The stock solution is filtered through a 0.45 μm PP filter element and a 0.2 μm PVDF sterilization filter element in sequence and then sealed in a low-density polyethylene plastic bottle.

10. The use of the children's bionic vernix caseosa skin care composition according to any one of claims 1 to 8, characterized in that: The children's bionic vernix caseosa skin care composition is used in preparing children's skin care products.

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