Traditional Chinese medicine composition and application thereof in preparation of medicine for preventing and / or treating hyperlipemia

Abstract

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition and application thereof in preparation of a medicine for preventing and / or treating hyperlipemia. The traditional Chinese medicine composition comprises the following traditional Chinese medicine components: pericarpium citri reticulatae, poria cocos, lotus leaves, semen cassiae, fingered citron, semen coicis and hawthorn. Furthermore, the traditional Chinese medicine composition also comprises the following traditional Chinese medicine components: semen armeniacae amarae, semen pruni, semen persicae and fructus cannabis. The invention provides a brand-new traditional Chinese medicine composition, and research shows that the composition has a good effect of preventing and / or treating hyperlipemia; therefore, the application of the compound in preparing the medicine for preventing and / or treating the hyperlipemia has important application value.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition and application thereof in preparing a medicine for preventing and / or treating hyperlipidemia. Background Art

[0002] Hyperlipidemia (HLP) is a chronic disease characterized by abnormal lipid metabolism. Its main features include increased serum cholesterol, triglycerides, and low-density lipoprotein cholesterol, and decreased serum high-density lipoprotein cholesterol. It is clinically divided into hypercholesterolemia, hypertriglyceridemia, mixed hyperlipidemia, and high-low-density lipoproteinemia. With the improvement of people's living standards and changes in lifestyle, the incidence of hyperlipidemia has increased year by year, and it is showing a trend of younger age. Hyperlipidemia has become an important public health issue. Many studies have shown that hyperlipidemia is one of the independent risk factors for many cardiovascular and cerebrovascular diseases, such as atherosclerosis, coronary heart disease, myocardial infarction, stroke, etc. Therefore, effective prevention of hyperlipidemia is also an important way to prevent cardiovascular and cerebrovascular diseases.

[0003] In terms of western medicine treatment, based on changing diet and improving lifestyle, intervention with lipid-lowering drugs is often used according to the severity of the disease. Currently, lipid-lowering drugs are mainly divided into statins, fibrates, niacin, intestinal cholesterol absorption inhibitors, proprotein convertase subtilisin / kexin type 9 (PCSK9) inhibitors, etc. Due to the long treatment course of hyperlipidemia, clinical studies have shown that long-term use of lipid-lowering drugs can cause a series of adverse reactions, such as statins may increase liver enzymes, cause muscle pain, rhabdomyolysis, and increase blood sugar; fibrates can cause skin itching, joint pain and gastrointestinal reactions; niacin causes skin flushing, etc. Therefore, finding lipid-lowering drugs with good efficacy and few side effects has always been a hot topic of research. In recent years, the advantages of traditional Chinese medicine in terms of multi-pathways, multi-targets, integrated regulation of body functions, and fewer adverse reactions have gradually attracted the attention of researchers at home and abroad.

[0004] There is no such name as "hyperlipidemia" in traditional Chinese medicine. It is generally believed that hyperlipidemia belongs to the category of "phlegm turbidity", "blood stasis", "phlegm and fluid" in traditional Chinese medicine. In traditional Chinese medicine, the causes of its occurrence are mostly attributed to "phlegm", "turbidity", "dampness", "stasis", etc. Traditional Chinese medicine believes that the basic pathogenesis of hyperlipidemia is due to deficiency of the root and excess of the superficial. The root deficiency mainly refers to the deficiency of the liver, spleen and kidney, improper diet, and spleen dysfunction; the second is liver dysfunction, and it is difficult to distinguish between clear and turbid; the third is kidney dysfunction, and condensation into fat. Spleen dysfunction, liver dysfunction, and kidney dysfunction are the internal pathological basis of hyperlipidemia. The superficial excess mainly refers to phlegm turbidity, blood stasis, and fat turbidity, which are pathological products of visceral qi dysfunction. In clinical practice, phlegm and blood stasis are more common. Therefore, based on the TCM differentiation of hyperlipidemia, hyperlipidemia can be treated from the spleen, liver, kidney, or phlegm or phlegm stasis. Generally, those with deficiency should be treated with methods of strengthening the spleen and replenishing qi, tonifying the liver and kidneys, nourishing blood and replenishing essence; those with excess should be treated with methods of promoting dampness and resolving phlegm, promoting blood circulation and removing blood stasis, clearing the bowels and purging turbidity, soothing the liver and regulating qi, etc.; those with a mixture of deficiency and excess should take into account both the symptoms and the root cause, and use both tonification and purgation.

[0005] In summary, providing a traditional Chinese medicine that has the function of preventing and / or treating hyperlipidemia has the application value of traditional Chinese medicine. Summary of the invention

[0006] In order to overcome at least one technical problem existing in the prior art, the present invention provides a Chinese medicine composition and its use in preparing a medicament for preventing and / or treating hyperlipidemia.

[0007] The present invention first provides a traditional Chinese medicine composition, which comprises the following traditional Chinese medicine components: dried tangerine peel, tuckahoe, lotus root

[0008] Leaf, decision

[0009] Mingzi, bergamot, coix seed and hawthorn.

[0010] The present invention provides a new Chinese medicine composition comprising dried tangerine peel, Poria cocos, lotus leaf, cassia seed, bergamot, coix seed and hawthorn. Studies have shown that the composition has a good effect in preventing and / or treating hyperlipidemia.

[0011] Preferably, the traditional Chinese medicine composition comprises the following traditional Chinese medicine components in parts by weight: 5-40 parts of tangerine peel, 5-30 parts of Poria cocos, 5-30 parts of lotus leaf, 5-30 parts of cassia seed, 10-30 parts of bergamot, 5-30 parts of coix seed, and 5-30 parts of hawthorn.

[0012] Further preferably, the Chinese medicine composition comprises the following Chinese medicine components in parts by weight: 10 to 30 parts of dried tangerine peel,

[0014] 5-20 parts of Poria cocos, 5-20 parts of lotus leaves, 5-20 parts of Cassia seeds, 10-30 parts of bergamot, 5-20 parts of Coix seeds, and 10-30 parts of hawthorn.

[0015] Most preferably, the Chinese medicine composition comprises the following Chinese medicine components in parts by weight:

[0016] 15 parts of dried tangerine peel, 10 parts of Poria cocos, 10 parts of lotus leaf, 10 parts of cassia seed, 15 parts of bergamot, 10 parts of coix seed, and 15 parts of hawthorn;

[0017] Or, 10 parts of dried tangerine peel, 5 parts of Poria cocos, 5 parts of lotus leaf, 5 parts of cassia seed, 10 parts of bergamot, 5 parts of coix seed, and 10 parts of hawthorn;

[0018] Or, 20 parts of dried tangerine peel, 15 parts of Poria cocos, 15 parts of lotus leaves, 15 parts of cassia seeds, 20 parts of bergamot, 15 parts of coix seeds, and 20 parts of hawthorn.

[0019] Further preferably, the Chinese medicine composition also comprises the following Chinese medicine components: bitter almond, Prunus mume seed, peach kernel and hemp seed.

[0020] The inventors found in further research that the effect of preventing and / or treating hyperlipidemia in a traditional Chinese medicine composition obtained by further adding bitter almond, Prunus mume, peach kernel and hemp seed to a traditional Chinese medicine composition comprising tangerine peel, Poria cocos, lotus leaf, cassia seed, bergamot, coix seed and hawthorn was further significantly improved compared with the traditional Chinese medicine composition comprising tangerine peel, Poria cocos, lotus leaf, cassia seed, bergamot, coix seed and hawthorn.

[0021] The inventors also found in the study that in the composition of the traditional Chinese medicine composition containing tangerine peel, Poria cocos, lotus leaf, cassia seed, bergamot, coix seed and hawthorn, the four traditional Chinese medicines of bitter almond, Prunus mume, peach kernel and hemp seed must be further added at the same time to obtain the traditional Chinese medicine composition, so that its effect of preventing and / or treating hyperlipidemia can be further significantly improved; however, adding only two or three of bitter almond, Prunus mume, peach kernel and hemp seed cannot further significantly improve its effect of preventing and / or treating hyperlipidemia.

[0022] Further preferably, the Chinese medicine composition comprises the following Chinese medicine components in parts by weight: 5-40 parts of tangerine peel, 5-30 parts of Poria cocos, 5-30 parts of lotus leaf, 5-30 parts of cassia seed, 10-30 parts of bergamot, 5-30 parts of coix seed, 5-30 parts of hawthorn, 5-60 parts of bitter almond, 5-20 parts of Prunus mume seed, 5-20 parts of peach kernel, and 5-20 parts of hemp seed.

[0023] Still further preferably, the Chinese medicine composition comprises the following Chinese medicine components in parts by weight: 10-30 parts of tangerine peel, 5-20 parts of Poria cocos, 5-20 parts of lotus leaf, 5-20 parts of cassia seed, 10-30 parts of bergamot, 5-20 parts of coix seed, 10-30 parts of hawthorn, 10-40 parts of bitter almond, 5-20 parts of Prunus mume seed, 5-20 parts of peach kernel, and 5-20 parts of hemp seed.

[0024] Most preferably, the Chinese medicine composition comprises the following Chinese medicine components in parts by weight: 15 parts of dried tangerine peel, 10 parts of Poria cocos, 10 parts of lotus leaf, 10 parts of cassia seed, 15 parts of bergamot, 10 parts of coix seed, 15 parts of hawthorn, 30 parts of bitter almond, 10 parts of Prunus mume seed, 10 parts of peach kernel, and 10 parts of hemp seed;

[0025] Or, 10 parts of dried tangerine peel, 5 parts of Poria cocos, 5 parts of lotus leaf, 5 parts of cassia seed, 10 parts of bergamot, 5 parts of coix seed, 10 parts of hawthorn, 20 parts of bitter apricot kernel, 5 parts of Prunus mume seed, 5 parts of peach kernel, and 5 parts of hemp seed;

[0026] Or, 20 parts of dried tangerine peel, 15 parts of Poria cocos, 15 parts of lotus leaves, 15 parts of cassia seeds, 20 parts of bergamots, 15 parts of coix seeds, 20 parts of hawthorn, 60 parts of bitter almonds, 20 parts of Prunus mume seeds, 20 parts of peach kernels, and 20 parts of hemp seeds.

[0027] The present invention also provides a method for preparing a Chinese medicine composition for preventing and / or treating hyperlipidemia.

[0028] Application in medicine.

[0029] Preferably, the medicine uses the extract or extract obtained by using the above-mentioned Chinese medicine composition as raw material as the active ingredient.

[0030] Preferably, the extract is prepared by the following method:

[0031] The Chinese medicine composition is extracted with a solvent to obtain an extract.

[0032] Preferably, the extract is prepared by the following method:

[0033] The Chinese medicine composition is extracted with a solvent to obtain an extract; the extract is concentrated and dried to obtain the extract.

[0034] Preferably, the solvent is water, alcohol or an aqueous solution of alcohol.

[0035] Preferably, the alcohol is ethanol or methanol.

[0036] Preferably, the extraction is performed by heating and boiling for 1 to 3 hours.

[0037] Preferably, the extraction refers to heating reflux extraction, and the extraction time is 1 to 3 hours.

[0038] Preferably, the weight amount of the solvent is 5 to 15 times the total weight of the Chinese medicine raw materials.

[0039] Preferably, the pharmaceutical dosage form is granules, capsules, pastes, tablets, concentrated pills or oral liquid preparations.

[0040] Beneficial effects: The present invention provides a new Chinese medicine composition. Studies have shown that the composition has

[0041] It has a good effect in preventing and / or treating hyperlipidemia; therefore, using it to prepare a drug for preventing and / or treating hyperlipidemia has important application value.

[0042] In the best prescription of the present invention, it is based on the classic expectorant basic prescription "Erchen Decoction", in which tangerine peel and Poria are the main components of the prescription. Tangerine peel regulates qi and strengthens the spleen, eliminates dampness and resolves phlegm, and is a key medicine for treating phlegm. Modern pharmacological research also shows that it has the effect of promoting gallbladder and reducing serum cholesterol; Poria strengthens the spleen and eliminates dampness, so that dampness and phlegm disappear. Lotus leaf has the effect of promoting the circulation of clear yang, which helps the circulation of qi and blood, improves phlegm blocking qi stagnation and poor blood circulation. Modern research shows that lotus leaf can reduce fat and lose weight; Coix seed promotes water and infiltrates dampness, which helps water and dampness to come out of urination; Hawthorn is a key medicine for digesting greasy meat stagnation. Modern research shows that the fatty acids contained in it can promote fat digestion, reduce serum cholesterol and triglycerides, and can resist atherosclerosis; Cassia seed has the effect of reducing plasma total cholesterol and triglycerides, and can moisten the intestines and relieve constipation. In the prescription, peach kernel, Prunus mume kernel, apricot kernel, and tangerine peel are the main drug compatibility of the famous prescription "Wuren Pill" (derived from "Shiyi Dexiao Fang"), and hemp seed is added to moisten the intestines and relieve constipation. In summary, the treatment of hyperlipidemia can be very effective by resolving phlegm, relieving constipation, and lowering lipids. DETAILED DESCRIPTION

[0043] The present invention is further explained below in conjunction with specific examples, but the examples do not limit the present invention in any form.

[0044] Example 1 Chinese medicine composition

[0045] Take 15 parts of dried tangerine peel, 10 parts of Poria cocos, 10 parts of lotus leaf, 10 parts of cassia seed, 15 parts of bergamot, 10 parts of coix seed and 15 parts of hawthorn, mix them evenly to obtain the traditional Chinese medicine composition.

[0046] The "parts" in this embodiment and the following embodiments and comparative examples refer to "parts by weight".

[0047] Example 2 Chinese medicine composition

[0048] Take 10 parts of dried tangerine peel, 5 parts of Poria cocos, 5 parts of lotus leaf, 5 parts of cassia seed, 10 parts of bergamot, 5 parts of coix seed and 10 parts of hawthorn, mix them evenly to obtain the traditional Chinese medicine composition.

[0049] Example 3 Chinese medicine composition

[0050] Take 20 parts of dried tangerine peel, 15 parts of Poria cocos, 15 parts of lotus leaf, 15 parts of cassia seed, 20 parts of bergamot, 15 parts of coix seed and 20 parts of hawthorn, mix them evenly to obtain the traditional Chinese medicine composition.

[0051] Example 4 Chinese medicine composition

[0052] Take 15 parts of dried tangerine peel, 10 parts of Poria cocos, 10 parts of lotus leaf, 10 parts of cassia seed, 15 parts of bergamot, 10 parts of coix seed, 15 parts of hawthorn, 30 parts of bitter almond, 10 parts of Prunus mume seed, 10 parts of peach kernel and 10 parts of hemp seed and mix them evenly to obtain the Chinese medicine composition.

[0053] Example 5 Chinese medicine composition

[0054] Take 10 parts of dried tangerine peel, 5 parts of Poria cocos, 5 parts of lotus leaf, 5 parts of cassia seed, 10 parts of bergamot, 5 parts of coix seed, 10 parts of hawthorn, 20 parts of bitter almond, 5 parts of Prunus mume seed, 5 parts of peach kernel and 5 parts of hemp seed and mix them evenly to obtain the Chinese medicine composition.

[0055] Example 6 Chinese medicine composition

[0056] Take 20 parts of dried tangerine peel, 15 parts of Poria cocos, 15 parts of lotus leaf, 15 parts of cassia seed, 20 parts of bergamot, 15 parts of coix seed, 20 parts of hawthorn, 60 parts of bitter almond, 20 parts of Prunus mume seed, 20 parts of peach kernel and 20 parts of hemp seed and mix them evenly to obtain the Chinese medicine composition.

[0057] Comparative Example 1 Chinese medicine composition

[0058] Take 15 parts of dried tangerine peel, 10 parts of Poria cocos, 10 parts of lotus leaf, 10 parts of cassia seed, 15 parts of bergamot, 10 parts of coix seed, 15 parts of hawthorn, 30 parts of bitter almond and 10 parts of Prunus mume seed and mix them evenly to obtain the traditional Chinese medicine composition.

[0059] Comparative Example 2 Chinese medicine composition

[0060] Take 15 parts of dried tangerine peel, 10 parts of Poria cocos, 10 parts of lotus leaf, 10 parts of cassia seed, 15 parts of bergamot, 10 parts of coix seed, 15 parts of hawthorn, 10 parts of peach kernel and 10 parts of hemp seed and mix them evenly to obtain the Chinese medicine composition.

[0061] Comparative Example 3 Chinese medicine composition

[0062] Take 15 parts of dried tangerine peel, 10 parts of Poria cocos, 10 parts of lotus leaf, 10 parts of cassia seed, 15 parts of bergamot, 10 parts of coix seed, 15 parts of hawthorn, 10 parts of Prunus mume seed, 10 parts of peach kernel and 10 parts of hemp seed and mix them evenly to obtain the Chinese medicine composition.

[0063] Experimental Example 1

[0064] ApoE- / - mice (male mice, 6 weeks old) were taken. They were first given an ordinary diet for adaptive feeding for 1 week. After the adaptive feeding, they were fasted overnight and weighed. They were randomly divided into control group and experimental group according to their body weight (there should be no significant difference in body weight between groups). The control group was fed with ordinary diet, and the model group was fed with high-fat diet. The modeling period was 6 weeks. After the modeling was completed (at the end of the 6th week), blood was collected from the tail vein for blood lipid testing. There was a difference in blood lipid levels between the ordinary diet feeding group and the high-fat diet feeding group, indicating that the modeling was successful.

[0065] The mice with successful modeling were randomly divided into 6 groups according to serum TC levels (there should be no significant difference in blood lipid levels between groups), with 8 mice in each group, including model control group and drug groups 1 to 5. The mice in the drug group were gavaged with drugs according to their body weight (gavage dose was 100 mg / kg / day), once a day, for 6 consecutive weeks. The model control group and the normal control group were gavaged with an equal volume of saline (once a day). After gavage, all mice were fasted but not watered for 12 hours. The eyeballs were removed under abdominal anesthesia to obtain blood, and blood and liver were collected for analysis. The collected blood was tested for total cholesterol, triglycerides, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol levels; the results are shown in Table 1. During the entire experiment, the mental state, activity, food intake, water intake, etc. of the mice were observed. At the same time, the weight of the mice was measured once a week.

[0066] The preparation methods of the drugs tested in drug groups 1 to 5 are as follows: take the Chinese medicine compositions described in Example 1, Example 4, and Comparative Examples 1 to 3 respectively, add 10 times the total weight of water of the Chinese medicine compositions respectively, and reflux extract at 100°C for 1 hour. After the extraction, the extract is concentrated and dried to obtain an extract; the extract obtained by extracting each Chinese medicine composition is taken as a test drug.

[0067] Table 1. Experimental results of Chinese herbal medicine composition for preventing and / or treating hyperlipidemia

[0068]

[0069] From the experimental results in Table 1, it can be seen that the TC content, TG content and LDL-C content of the mice in the model control group are significantly higher than those in the normal control group, and the HDL-C content is significantly lower than that in the normal control group; this indicates that the modeling is successful.

[0070] It can be seen from the experimental results in Table 1 that the TC content, TG content and LDL-C content of the mice in the drug group 1 are significantly lower than those in the model control group; this shows that the traditional Chinese medicine composition of the present invention comprising dried tangerine peel, Poria cocos, lotus leaf, cassia seed, bergamot, coix seed and hawthorn has a good effect in preventing and / or treating hyperlipidemia.

[0071] From the experimental results in Table 1, it can be seen that the TC content, TG content and LDL-C content of the mice in drug group 2 are further significantly lower than those in drug group 1, and are close to those in the normal control group; this shows that the Chinese medicine composition obtained by further adding bitter almond, Prunus mume, peach kernel and hemp seed to the Chinese medicine composition comprising tangerine peel, Poria cocos, lotus leaf, cassia seed, bergamot, coix seed and hawthorn has a further significantly improved effect on preventing and / or treating hyperlipidemia compared to the Chinese medicine composition comprising tangerine peel, Poria cocos, lotus leaf, cassia seed, bergamot, coix seed and hawthorn; and has a very excellent effect on preventing and / or treating hyperlipidemia.

[0072] It can be seen from the experimental results in Table 1 that the TC content, TG content and LDL-C content of the mice in drug groups 3 to 4 were lower than those in drug group 1, but the reduction was not large, and the reduction was much smaller than that in drug group 2; this shows that in the composition of the traditional Chinese medicine composition comprising tangerine peel, Poria cocos, lotus leaf, cassia seed, bergamot, coix seed and hawthorn, the traditional Chinese medicine composition obtained by further adding four traditional Chinese medicines such as bitter almond, Prunus mume, peach kernel and hemp seed at the same time can further significantly improve its effect on preventing and / or treating hyperlipidemia; however, adding only two or three of bitter almond, Prunus mume, peach kernel and hemp seed cannot further significantly improve its effect on preventing and / or treating hyperlipidemia.

Claims

1. A Chinese medicine composition, characterized in that: It contains the following Chinese medicinal ingredients: tangerine peel, poria cocos, lotus leaf, cassia seed, bergamot, coix seed and hawthorn.

2. The Chinese medicine composition according to claim 1, characterized in that: The invention comprises the following traditional Chinese medicine components in parts by weight: 5-40 parts of dried tangerine peel, 5-30 parts of poria cocos, 5-30 parts of lotus leaf, 5-30 parts of cassia seed, 10-30 parts of bergamot, 5-30 parts of coix seed and 5-30 parts of hawthorn.

3. The Chinese medicine composition according to claim 1, characterized in that Contains the following Chinese medicine components in parts by weight: 10-30 parts of dried tangerine peel, 5-20 parts of Poria cocos, 5-20 parts of lotus leaves, 5-20 parts of cassia seeds, 10-30 parts of bergamot, 5-20 parts of coix seeds, and 10-30 parts of hawthorn.

4. The Chinese medicine composition according to claim 1, characterized in that: Contains the following Chinese medicine components in parts by weight: 15 parts of dried tangerine peel, 10 parts of Poria cocos, 10 parts of lotus leaf, 10 parts of cassia seed, 15 parts of bergamot, 10 parts of coix seed, and 15 parts of hawthorn; Or, 10 parts of dried tangerine peel, 5 parts of Poria cocos, 5 parts of lotus leaf, 5 parts of cassia seed, 10 parts of bergamot, 5 parts of coix seed, and 10 parts of hawthorn; Or, 20 parts of dried tangerine peel, 15 parts of Poria cocos, 15 parts of lotus leaves, 15 parts of cassia seeds, 20 parts of bergamot, 15 parts of coix seeds, and 20 parts of hawthorn.

5. The Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition also comprises the following Chinese medicine components: bitter almond, Prunus mume seed, peach seed and hemp seed.

6. The Chinese medicine composition according to claim 1, characterized in that: The invention comprises the following Chinese medicinal components in parts by weight: 5-40 parts of dried tangerine peel, 5-30 parts of poria cocos, 5-30 parts of lotus leaf, 5-30 parts of cassia seed, 10-30 parts of bergamot, 5-30 parts of coix seed, 5-30 parts of hawthorn, 5-60 parts of bitter almond, 5-20 parts of Prunus mume seed, 5-20 parts of peach kernel and 5-20 parts of hemp seed.

7. The Chinese medicine composition according to claim 6, characterized in that: The invention comprises the following Chinese medicinal components in parts by weight: 10-30 parts of dried tangerine peel, 5-20 parts of poria cocos, 5-20 parts of lotus leaf, 5-20 parts of cassia seed, 10-30 parts of bergamot, 5-20 parts of coix seed, 10-30 parts of hawthorn, 10-40 parts of bitter almond, 5-20 parts of Prunus mume seed, 5-20 parts of peach kernel and 5-20 parts of hemp seed.

8. The Chinese medicine composition according to claim 6, characterized in that: The invention comprises the following Chinese medicinal components in parts by weight: 15 parts of dried tangerine peel, 10 parts of poria cocos, 10 parts of lotus leaf, 10 parts of cassia seed, 15 parts of bergamot, 10 parts of coix seed, 15 parts of hawthorn, 30 parts of bitter almond, 10 parts of Prunus mume seed, 10 parts of peach kernel, and 10 parts of hemp seed; Or, 10 parts of dried tangerine peel, 5 parts of Poria cocos, 5 parts of lotus leaf, 5 parts of cassia seed, 10 parts of bergamot, 5 parts of coix seed, 10 parts of hawthorn, 20 parts of bitter apricot kernel, 5 parts of Prunus mume seed, 5 parts of peach kernel, and 5 parts of hemp seed; Or, 20 parts of dried tangerine peel, 15 parts of Poria cocos, 15 parts of lotus leaves, 15 parts of cassia seeds, 20 parts of bergamots, 15 parts of coix seeds, 20 parts of hawthorn, 60 parts of bitter almonds, 20 parts of Prunus mume seeds, 20 parts of peach kernels, and 20 parts of hemp seeds.

9. The Chinese medicine composition according to any one of claims 1 to 8 for preparing a medicine for preventing and / or treating hyperlipidemia Application in things.

10. The use according to claim 9, characterized in that: The medicine uses the extract or extract obtained by using the above-mentioned Chinese medicine composition as raw material as the effective ingredient.

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