Targeted low-temperature protection method

Abstract

The invention discloses a targeted low-temperature protection method, and belongs to the technical field of targeted brain low-temperature treatment.The method comprises the steps that venous blood flows to a vein blood drawing tube through a blood pump and flows into oxygen supply equipment; the oxygen content of the venous blood is increased in the oxygen supply equipment, and the venous blood is converted into first arterial blood; the first arterial blood flows into the common carotid artery through the carotid artery blood return tube and is mixed with blood in the common carotid artery to form second arterial blood; the second arterial blood flows out of the common neck artery and enters the constant-temperature equipment through the artery blood guide tube; the second arterial blood is cooled in the constant-temperature equipment to form third arterial blood; the cooled third arterial blood enters the intracranial aorta along the intracranial arterial blood return vessel, and the third arterial blood entering the intracranial aorta is low-speed blood flow. The problem that in the prior art, the treatment efficiency is low due to the fact that assisted respiration and targeted low-temperature treatment cannot be conducted on a patient at the same time in a treatment method is solved. The treatment cost is saved, and the universality of the targeted low-temperature treatment method is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of targeted brain hypothermia treatment, and in particular to a targeted hypothermia protection method. Background Art

[0002] Acute hypoxic-ischemic brain injury (such as after cardiopulmonary resuscitation and severe asphyxia) is a common critical illness in the intensive care unit. Not only is the mortality rate high, but patients who are cured are left with neurological sequelae. Target temperature management is a treatment method that has been proven to reduce brain damage and improve neurological prognosis. It is through artificial physical lowering of the whole body temperature or local brain temperature, thereby reducing brain oxygen consumption and promoting brain function recovery. At present, traditional sub-hypothermia treatment methods include systemic sub-hypothermia and local sub-hypothermia. Systemic sub-hypothermia generally uses whole body surface cooling or intravascular cooling to reduce body temperature to about 33°C, but the accompanying side effects include abnormal coagulation function, low immune function, respiratory tract infection, bedsores, arrhythmia, hypotension, electrolyte disorders, etc. As for local sub-hypothermia, ice caps or dressings are used for cooling, but this cooling effect is poor and often cannot meet the requirements of sub-hypothermia treatment.

[0003] For the current targeted cryogenic treatment methods, for example, the intelligent targeted brain cryogenic equipment, control method, system and storage medium disclosed in patent CN202310747889.9 only contains one passage inside, and the above invention patent is to draw blood from the vein and return it from the artery. This means that in addition to low-temperature treatment of the blood, oxygen treatment is also required. This means that if extracorporeal assisted oxygen supply and targeted cryogenic treatment are required, two instruments need to be used, which not only increases the cost of treatment, but also reduces the treatment efficiency.

[0004] Therefore, how to provide a targeted cryoprotection method to improve the defects existing in the above-mentioned patent treatment is a technical problem that needs to be urgently solved by those skilled in the art. Summary of the invention

[0005] To this end, the present invention provides a targeted hypothermia protection method to solve the problem of low treatment efficiency in the prior art because the treatment method cannot simultaneously perform assisted breathing and targeted hypothermia treatment on the patient.

[0006] In order to achieve the above object, the present invention provides the following technical solutions:

[0007] The present invention discloses a targeted cryoprotection method, comprising the following steps:

[0008] Step S1: venous blood flows to the venous drainage tube through the blood pump and then flows into the oxygen supply equipment;

[0009] Step S2: the oxygen content of the venous blood is increased in the oxygen supply device to convert the venous blood into first arterial blood;

[0010] Step S3: the first arterial blood flows into the common carotid artery through the carotid return blood vessel and mixes with the blood in the common carotid artery to form the second arterial blood;

[0011] Step S4: the second arterial blood flows out from the common carotid artery and enters the constant temperature device through the arterial blood vessel:

[0012] Step S5: the second arterial blood is cooled in the constant temperature device to form third arterial blood;

[0013] Step S6: the third arterial blood after the cooling treatment enters the intracranial aorta along the intracranial arterial return blood vessel, and the third arterial blood entering the intracranial aorta is a low-speed blood flow.

[0014] In a possible implementation, the blood pump in step S1 draws blood, specifically including the following steps:

[0015] Step S101: placing one end of the venous drainage tube at the centripetal end of the internal jugular vein or the femoral vein, and passing the other end through the blood pump and connected to the oxygen supply device;

[0016] Step S102: starting the blood pump and squeezing the venous drainage tube to change the pressure value of the venous drainage tube;

[0017] Step S103: the venous blood flows along the venous drainage tube and into the oxygen supply device.

[0018] In a possible implementation, the blood pump is a roller pump.

[0019] In a possible implementation, the arterial blood cooling treatment method in step S5 is to pre-set the temperature of the constant temperature water tank in the constant temperature device, circulate the second arterial blood in the constant temperature water tank, keep the second arterial blood consistent with the water temperature in the constant temperature water tank, and form the third arterial blood, the bleeding end of the constant temperature water tank is provided with a temperature sensor, the third arterial blood flows through the temperature sensor, and the temperature of the third arterial blood is detected.

[0020] In a possible implementation, the second arterial blood enters the constant temperature device in step S4, specifically including the following steps:

[0021] Step S401: connecting one end of the arterial blood vessel to the common carotid artery, and inserting the other end of the arterial blood vessel into the constant temperature device;

[0022] Step S402: a drainage pump is provided in the arterial drainage blood vessel, wherein the drainage pump assists in draining the second arterial blood with insufficient oxygen supply;

[0023] Step S403: the second arterial blood flows along the arterial drainage tube, passes through the drainage pump, and flows into the constant temperature device.

[0024] In a possible implementation, returning the third arterial blood to the intracranial aorta in step S6 specifically includes the following steps:

[0025] Step S601: inserting one end of the intracranial arterial return blood vessel into the intracranial aorta, and inserting the other end of the intracranial arterial return blood vessel into the constant temperature device;

[0026] Step S602: The third arterial blood returns to the intracranial aorta via the intracranial arterial return blood vessel.

[0027] In a possible implementation, the increasing of the venous blood oxygen content in step S2 specifically includes the following steps:

[0028] Step S201: the venous blood flows into the oxygen supply device through the venous drainage tube;

[0029] Step S202: the hollow oxygen mixer in the oxygen supply device temporarily stores the venous blood;

[0030] Step S203: the air-oxygen mixer diffuses the CO2 in the venous blood;

[0031] Step S204: the air oxygen supply device in the oxygen supply equipment inputs O2 into the venous blood and assists CO2 diffusion, so that the O2 content of the venous blood increases and is converted into the first arterial blood.

[0032] Compared with the existing targeted cryotherapy method, the present invention combines the targeted cryotherapy method with CO2 removal therapy and ECMO emergency plan. By drawing out venous blood and using oxygen supply equipment to increase the O2 content, the venous blood is converted into first arterial blood. The first arterial blood enters the common carotid artery to participate in blood circulation. At the same time, a part of the first arterial blood is mixed with the blood in the common carotid artery to form second arterial blood. This part of the second arterial blood enters the constant temperature equipment for low temperature treatment, so that the blood temperature is reduced to form third arterial blood. The third arterial blood flows into the intracranial aorta to reduce brain oxygen consumption. In this way, multiple diseases of the patient can be treated at the same time, the equipment required for treatment is reduced, more patients can be treated at the same time, the treatment efficiency is improved, and the treatment cost is effectively reduced. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] In order to more clearly illustrate the implementation methods of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for the implementation methods or the description of the prior art. Obviously, the drawings in the following description are only exemplary, and for ordinary technicians in this field, other implementation drawings can be derived from the provided drawings without creative work.

[0034] The structures, proportions, sizes, etc. illustrated in this specification are only used to match the contents disclosed in the specification so as to facilitate understanding and reading by persons familiar with the technology. They are not used to limit the conditions under which the present invention can be implemented, and therefore have no substantial technical significance. Any structural modification, change in proportion or adjustment of size shall still fall within the scope of the technical contents disclosed in the present invention without affecting the effects and purposes that can be achieved by the present invention.

[0035] Figure 1 A flow chart of the targeted cryoprotection method provided by the present invention;

[0036] Figure 2 A specific flow chart of step S1 in the targeted cryoprotection method provided by the present invention;

[0037] Figure 3 A specific flow chart of step S4 in the targeted cryoprotection method provided by the present invention;

[0038] Figure 4 A specific flow chart of step S6 in the targeted cryoprotection method provided by the present invention;

[0039] Figure 5 A specific flow chart of step S2 in the targeted cryoprotection method provided by the present invention; DETAILED DESCRIPTION

[0040] The following is a description of the implementation of the present invention by specific embodiments. People familiar with the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0041] In order to solve the problem of low treatment efficiency caused by the inability to simultaneously perform assisted breathing and targeted hypothermia treatment on patients in the prior art, a targeted hypothermia protection method is provided. Figure 1 As shown, the following steps are included:

[0042] Step S1: venous blood flows to the venous drainage tube through the blood pump and then flows into the oxygen supply equipment;

[0043] Step S2: the oxygen content of the venous blood is increased in the oxygen supply device, and the venous blood is converted into first arterial blood;

[0044] Step S3: the first arterial blood flows into the common carotid artery through the carotid return blood vessel and mixes with the blood in the common carotid artery to form the second arterial blood;

[0045] Step S4: The second arterial blood flows out from the common carotid artery and enters the constant temperature device through the arterial blood vessel:

[0046] Step S5: the second arterial blood is cooled in a constant temperature device to form third arterial blood;

[0047] Step S6: The third arterial blood after the cooling treatment enters the intracranial aorta along the intracranial arterial return blood vessel. The third arterial blood entering the intracranial aorta is a low-speed blood flow.

[0048] The use process of the present invention is to first install the venous drainage blood vessel, the carotid return blood vessel, the arterial drainage blood vessel and one end of the intracranial artery return blood vessel in the oxygen supply equipment and the constant temperature equipment, and then the other end of the venous drainage blood vessel will be set in the human vein, and the other ends of the carotid return blood vessel, the arterial drainage blood vessel and the intracranial artery return blood vessel are all inserted in different arteries. Venous blood is extracted by a blood pump and enters the oxygen supply equipment. Oxygen is provided by the oxygen supply equipment to increase the oxygen content in the venous blood and squeeze out the carbon dioxide in the vein. After the oxygen content is increased, the venous blood is converted into the first arterial blood and enters the common carotid artery. Because the patient needs assisted breathing, the oxygen content of the first arterial blood after oxygenation by the oxygen supply equipment is higher. Part of the first arterial blood enters the human blood circulation through the common carotid artery, and the other part flows to the constant temperature equipment for cooling treatment. After the cooling treatment, it enters the intracranial aorta to perform targeted low-temperature treatment on the brain organs.

[0049] In a specific embodiment, Figure 2 In step S1, the blood pump draws blood, specifically including the following steps:

[0050] Step S101: one end of the venous drainage tube is placed at the centripetal end of the internal jugular vein or the femoral vein, and the other end is passed through a blood pump and connected to an oxygen supply device;

[0051] Step S102: starting the blood pump and squeezing the venous drainage tube to change the pressure value of the venous drainage tube;

[0052] Step S103: The venous blood flows along the venous drainage tube and into the oxygen supply device.

[0053] On the basis of the previous embodiment, one end of the venous drainage tube is set in the centripetal end of the internal jugular vein or the femoral vein by puncture, and the blood pump changes the pressure in the tube so that the air pressure in the venous drainage tube is lower than the venous pressure. At this time, under the action of the pressure difference, the venous blood will flow out along the venous drainage tube, and after passing through the blood pump, the venous blood enters the oxygen supply equipment for oxygen supply.

[0054] On the basis of the previous embodiment, the blood pump is a roller pump. The principle of the roller pump is the same as that of the CPB roller pump, that is, the pressure is generated by squeezing the pipeline (negative pressure before the pump attracts blood into the pump, and positive pressure after the pump drives the blood into the patient's body) to drive the blood flow in the pipeline. The blood flow rate is affected by the pipeline diameter, the blocking pressure of the pump roller, the pump speed and the blood volume. Its advantage is that it can provide a stable blood flow, and its main disadvantage is that it is easy to cause continuous changes in pressure and easily generate gas. By adjusting the roller pump, the blood drainage flow rate is changed to improve the treatment efficiency.

[0055] In a specific embodiment, the arterial blood cooling treatment method in step S5 is to pre-set the temperature of the constant temperature water tank in the constant temperature equipment, circulate the second arterial blood in the constant temperature water tank, keep the second arterial blood consistent with the water temperature in the constant temperature water tank, and form the third arterial blood. A temperature sensor is provided at the bleeding end of the constant temperature water tank, the third arterial blood flows through the temperature sensor, and the temperature of the third arterial blood is detected.

[0056] On the basis of the previous embodiment, the constant temperature water tank uses a mixture of cold and hot water for temperature preset. Through the mixed regulation of cold and hot water, the temperature of the heat exchange with the second arterial blood can be quickly and accurately controlled between 4 and 40 degrees, and the appropriate blood return temperature can be effectively selected according to the patient's condition, ensuring that discomfort is avoided while treating the disease. The bleeding temperature of the third arterial blood is detected by a temperature sensor. When the bleeding temperature does not reach the preset cooling temperature, the temperature in the constant temperature water tank can be adjusted again so that the bleeding temperature can be adjusted to an effective treatment temperature to perform targeted hypothermia treatment on the patient's brain.

[0057] In a specific embodiment, Figure 3 In step S4, the second arterial blood enters the constant temperature device, which specifically includes the following steps:

[0058] Step S401: connecting one end of the arterial blood vessel to the common carotid artery, and inserting the other end of the arterial blood vessel into a constant temperature device;

[0059] Step S402: a drainage pump is provided in the arterial drainage blood vessel, and the drainage pump assists in draining the second arterial blood with insufficient oxygen supply;

[0060] Step S403: The second arterial blood flows along the arterial drainage tube through the drainage pump and into the constant temperature device.

[0061] Based on the previous embodiment, the drainage pump generally also adopts a roller pump. This drainage pump is generally used when the oxygen content in the second arterial blood is insufficient, resulting in insufficient blood pressure and unable to enter the constant temperature device. A roller pump is needed to squeeze the pipeline to change the pressure and assist the second arterial blood to flow into the constant temperature device.

[0062] In a specific embodiment, Figure 4 In step S6, the third arterial blood is returned to the intracranial aorta, which specifically includes the following steps:

[0063] Step S601: inserting one end of the intracranial arterial return blood vessel into the intracranial aorta, and inserting the other end of the intracranial arterial return blood vessel into a constant temperature device;

[0064] Step S602: The third arterial blood returns to the blood vessel through the intracranial artery and enters the intracranial aorta.

[0065] On the basis of the previous embodiment, the third arterial blood is blood that has been cooled by a constant temperature device. It is generally a low-speed blood flow with a blood flow rate of 5-10ml / kg.min. It flows into the intracranial aorta at a slower flow rate to slowly cool the brain, which can further reduce brain oxygen consumption and is a treatment method to promote brain function recovery.

[0066] In a specific embodiment, Figure 5 , the venous blood oxygen content increases in step S2, specifically comprising the following steps:

[0067] Step S201: venous blood flows into the oxygen supply device through the venous drainage tube;

[0068] Step S202: The hollow oxygen mixer in the oxygen supply device temporarily stores the venous blood;

[0069] Step S203: the air-oxygen mixer diffuses the CO2 in the venous blood;

[0070] Step S204: the oxygen supply device in the oxygen supply equipment inputs O2 into the venous blood and assists the diffusion of CO2, so that the O2 content of the venous blood increases and is converted into the first arterial blood.

[0071] On the basis of the previous embodiment, in the air-oxygen mixer, the interior is generally divided into two spaces by a partition, one side is used for the flow of venous blood, and in this space, an air-oxygen oxygen supply machine is used to fill the blood with oxygen. Carbon dioxide itself diffuses well in the blood, and combined with hemoglobin in the blood to bind oxygen, the oxygen content in the blood increases, but the space for accommodating gas in the blood is limited, so the entry of oxygen will squeeze out carbon dioxide, and the increase in oxygen content in the blood will cause the blood to be converted into first arterial blood, which flows into another space. The blood transfer between the two spaces is generally achieved through a one-way valve, which can effectively prevent the blood in the two spaces from mixing, and the first arterial blood enters the common carotid artery to participate in blood circulation.

[0072] Although the present invention has been described in detail above by general description and specific embodiments, it is obvious to those skilled in the art that some modifications or improvements can be made to the present invention. Therefore, these modifications or improvements made without departing from the spirit of the present invention all belong to the scope of protection claimed by the present invention.

Claims

1. A targeted cryoprotection method, characterized in that: The steps include: Step S1: venous blood flows to the venous drainage tube through the blood pump and then flows into the oxygen supply equipment; Step S2: the oxygen content of the venous blood is increased in the oxygen supply device to convert the venous blood into first arterial blood; Step S3: the first arterial blood flows into the common carotid artery through the carotid return blood vessel and mixes with the blood in the common carotid artery to form the second arterial blood; Step S4: the second arterial blood flows out from the common carotid artery and enters the constant temperature device through the arterial blood vessel: Step S5: the second arterial blood is cooled in the constant temperature device to form third arterial blood; Step S6: the third arterial blood after the cooling treatment enters the intracranial aorta along the intracranial arterial return blood vessel, and the third arterial blood entering the intracranial aorta is a low-speed blood flow.

2. The targeted cryoprotection method according to claim 1, characterized in that: In step S1, the blood pump draws blood, specifically including the following steps: Step S101: placing one end of the venous drainage tube at the centripetal end of the internal jugular vein or the femoral vein, and passing the other end through the blood pump and connected to the oxygen supply device; Step S102: starting the blood pump and squeezing the venous drainage tube to change the pressure value of the venous drainage tube; Step S103: the venous blood flows along the venous drainage tube and into the oxygen supply device.

3. The targeted cryoprotection method according to claim 2, characterized in that: The blood pump is a roller pump.

4. The targeted cryoprotection method according to claim 1, characterized in that: The arterial blood cooling treatment method in step S5 is to pre-set the temperature of the constant temperature water tank in the constant temperature device, circulate the second arterial blood in the constant temperature water tank, keep the second arterial blood consistent with the water temperature in the constant temperature water tank, and form the third arterial blood. The bleeding end of the constant temperature water tank is provided with a temperature sensor, the third arterial blood flows through the temperature sensor, and the temperature of the third arterial blood is detected.

5. The targeted cryoprotection method according to claim 1, characterized in that: In step S4, the second arterial blood enters the constant temperature device, which specifically includes the following steps: Step S401: connecting one end of the arterial blood vessel to the common carotid artery, and inserting the other end of the arterial blood vessel into the constant temperature device; Step S402: a drainage pump is provided in the arterial drainage blood vessel, wherein the drainage pump assists in draining the second arterial blood with insufficient oxygen supply; Step S403: the second arterial blood flows along the arterial drainage tube, passes through the drainage pump, and flows into the constant temperature device.

6. The targeted cryoprotection method according to claim 1, characterized in that: In step S6, the third arterial blood is returned to the intracranial aorta, specifically comprising the following steps: Step S601: inserting one end of the intracranial arterial return blood vessel into the intracranial aorta, and inserting the other end of the intracranial arterial return blood vessel into the constant temperature device; Step S602: The third arterial blood returns to the intracranial aorta via the intracranial arterial return blood vessel.

7. The targeted cryoprotection method according to claim 1, characterized in that: The step S2 in which the venous blood oxygen content is increased specifically includes the following steps: Step S201: the venous blood flows into the oxygen supply device through the venous drainage tube; Step S202: the hollow oxygen mixer in the oxygen supply device temporarily stores the venous blood; Step S203: the air-oxygen mixer diffuses the CO2 in the venous blood; Step S204: the air oxygen supply device in the oxygen supply equipment inputs O2 into the venous blood and assists CO2 diffusion, so that the O2 content of the venous blood increases and is converted into the first arterial blood.

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