41results about "Oxygenators" patented technology

A blood pump-oxygenator system (250A, 250B, 250C) for increasing perfusion and oxygen levels in the body of a patient (P), comprising: a blood inlet (80) and a blood outlet (90) connected to form a circuit operable as a cardiopulmonary bypass system suitable for extracorporeal treatment of the blood of the patient; a first blood pump (11) and a first oxygenator (20), wherein the first blood pump (11) is configured to deliver blood from the patient (P) through the circuit to the blood inflow port (80), through the first oxygenator (20), out of the blood outflow port (90) and back to the patient (P). The system further comprises a second blood pump (13) and a second oxygenator (21), wherein the second blood pump (13) is configured to deliver blood from the patient (P) through the circuit to the blood inflow port (80), through the second oxygenator (20), out of the blood outflow port (90) and back to the patient (P). The circuit comprises a first branch (101) and a second branch (102) arranged in parallel with each other, the first branch (101) accommodating the first blood pump (11) and the first oxygenator (20), and the second branch (102) accommodating the second blood pump (13) and the second oxygenator (21). The system further comprises a pump control unit (290) wherein the first and second blood pumps (11, 13) are configured to be controlled by the pump control unit (290) to increase or decrease the blood flow through the corresponding oxygenator (20, 21) by changing the proportion of the blood flow through the first and second oxygenator (20, 21).

The present disclosure provides systems and methods for controlling gas-enrichment, e.g., oxygen-enrichment, therapy. A portable device (100) includes a pressurized container (102) and actuator (110) for portable delivery of gas-enrichment therapy.

The present invention relates to a method by which intravenous fluids, blood or artificial blood containing high levels of mechanically infused dissolved oxygen can be used to maintain appropriate oxygen levels in venous blood to provide short term oxygenation support to a compromised patient or trauma patient. In one aspect, a system and method for oxygenating a biological fluid for a compromised subject or trauma subject in need of oxygenation support to maintain the subject at an appropriate oxygen level is provided, the method comprising: supplying oxygen from an oxygen source; and dissolving an amount of the supplied oxygen into the biological fluid to obtain an oxygen enriched biological fluid.

A method for onsite hemorrhage control in trauma patients using a portable rapid autotransfusion device can involve recovering a first portion of patient blood from an extravascular space into a fluid reservoir of the device. A negative internal pressure can be applied to the blood. The blood can be conditioned, such as by oxygenating and removing carbon dioxide. The conditioned blood can be returned to the patient intravenously at a rate that matches the rate of blood recovery, ensuring that the net volume of returned blood is maintained substantially equal to the net volume of removed blood.

Systems and methods for gas exchange in a patient are provided that use an external circuit to cause oxygenation perfusion in a body cavity (such as an abdomen) of the patient using an inert chemical (e.g., perfluorocarbon), independent of lungs. The external circuit includes components configured to control properties of the chemical, including temperature, flow rate, pressure, oxygenation percentage, and carbon dioxide percentage. The systems also include safety features to reduce a likelihood of injury to the patient. Each of the safety features and the properties of the chemical can be controlled by a healthcare worker, such as a physician, a nurse, or an emergency operator, for a particular patient.

The present disclosure describes intravascular oxygenation systems and methods with one or more of improved oxygen diffusion flux, improved resistance to bubble formation on the surface of non-porous hollow fibers, and reduced size. The systems and methods include a pneumatic inlet coupled to a pneumatic source that provides a gas containing oxygen at a high pressure. A plurality of hollow fiber membranes (HFM) are in pneumatic communication with the pneumatic inlet to receive the gas containing oxygen and with an outlet to exhaust a partially deoxygenated gas. An electronic controller drives the motor to oscillate the plurality of HFMs to cause a diffusive flux of the gas containing oxygen from the plurality of HFMs into a region of interest of a subject. The electronic controller may drive the motor according to an oscillation pattern, which may include a macro-oscillation with superimposed micro-oscillations.

The double-lumen pipeline for arterial drainage of the application comprises a first pipeline, a second pipeline, a first end and a second end of the first pipeline are both open, a balloon is formed around the first pipeline near the second end of the first pipeline, the balloon is connected with a third pipeline, a first end of the third pipeline is located outside the arterial blood vessel, the balloon is inflated to abut on the inner wall of the arterial blood vessel under proper pressure to form a blockage in the arterial blood vessel, blood upstream of the balloon is led out to the outside through the first pipeline under the action of arterial pressure to facilitate corresponding treatment of the led-out blood to obtain treated blood, a first end of the second pipeline is open, a second end of the second pipeline is closed, a side hole is formed on the second pipeline near the second end of the second pipeline, the side hole is close to the downstream of the balloon and far away from the upstream of the balloon, and the treated blood is injected into the second pipeline through the first end of the second pipeline and then injected into the downstream of the balloon through the side hole of the second pipeline.

An arterial cannula for ECMO includes a main arterial cannula with an inner wall and having a first end with a blood outflow port. The first end is intended to be introduced into an artery so as to inject the blood retrogradely into the artery. A retro-perfusion cannula is configured to be translatably movable between a retracted position in the first end of the main arterial cannula and a deployed position at least partly outside the main arterial cannula and opposite the blood outflow port of the main arterial cannula.

Certain embodiments of the invention are directed to methods of adjusting the concentration of one or more electrolytes in a patient's blood using a counter current electrolyte solution.

The invention relates to a device for the controlled in vivo absorption of CO2, comprising a catheter which has a gas-permeable membrane and a CO2-absorbing carrier medium. The invention additionally relates to a set comprising said device and to the device or set for use in the prophylaxis or treatment of diseases of the respiratory system or for use in the induction of hypercapnia in a patient.

A system to oxygenate blood may include an inlet channel configured to receive blood in a first state, a microbubble generation interface coupled to the inlet channel, the microbubble generation interface including a first stream of a first portion of the blood in the first state; and an inlet, coupled to a downstream end of the first stream, configured to provide microbubbles to the blood in the first state to cause the blood to change to a second state, and the system further including an outlet channel downstream of the inlet to flow the blood in the second state.

A foam management system (1000), apparatus (300), and method are disclosed for a foamed blood product , the apparatus comprising an antifoaming device (400) for receiving a pressurized foam (60) from a pressurized foamed blood product, said antifoaming device allowing a gas (68) to be separated from said foam (60), wherein said antifoaming device converts said pressurized foam (60) into said blood product, allowing the blood product to be recovered from said foam (60), substantially without the foam.

An advanced system and methods for treatment of cancer and other diseases including complications from late-stage viral infections by inducing hyperthermia in a patient relying on withdrawing blood from the patient and returning the withdrawn blood to the patient to establish a continuous extracorporeal flow circuit. Blood is heated by passing through the extracorporeal circuit at a controlled rate until a target body core temperature in is achieved. An innovative concept inherent in the instant invention is the incorporation of an ECMO machine to provide oxygenation. Usually, the blood will be subjected to a continuously re-circulating dialysis to balance electrolytes. Additionally, the blood will be subjected to a continuously recirculating regeneration through a carbon sorbent column where toxins and contaminants are removed. The blood temperature is maintained at the target blood temperature for a treatment period, and the blood is cooled after the treatment period has been completed.

This invention relates to a process through which intravenous fluids, blood, or artificial blood containing high-levels of mechanically-injected dissolved oxygen can be used to maintain appropriate oxygen levels in the venous blood and thereby provide short-term oxygenation support for compromised or trauma patients. In one aspect, there is provided a system and process for oxygenating a biological fluid for use in a compromised or a trauma subject in need of oxygenation support to maintain appropriate oxygen levels in the subject, the process comprising: supplying oxygen gas from an oxygen source; and dissolving an amount of the supplied oxygen into a biological fluid to obtain an oxygen enriched biological fluid.

The present disclosure provides systems and methods for controlling gas-enrichment, e.g., oxygen-enrichment, therapy. One or more sensors and / or one or more imaging systems may be used to measure or determine one or more physiological parameters of a patient. Feedback regarding the one or more physiological parameters or microvascular resistance may be provided to titrate or control the gas-enrichment therapy.

According to some embodiments, a system may treat blood outside the body of a patient. The system may include one or more pumps configured to draw blood from a patient into a fluid flow path at a rate, for example, of 5-7 liters per minute. The system may include one or more heat exchangers coupled to the fluid flow path and configured to heat the blood, for example, to a temperature above 42 degrees Celsius and below 43.2 degrees Celsius.

A method for onsite hemorrhage control in trauma patients using a portable rapid autotransfusion device can involve recovering a first portion of patient blood from an extravascular space into a fluid reservoir of the device. A negative internal pressure can be applied to the blood. The blood can be conditioned, such as by oxygenating and removing carbon dioxide. The conditioned blood can be returned to the patient intravenously at a rate that matches the rate of blood recovery, ensuring that the net volume of returned blood is maintained substantially equal to the net volume of removed blood.

To provide a catheter that can be reduced in diameter, can reduce a load on the heart, and can effectively deliver oxygenated blood to important organs.SOLUTION: A catheter includes: a tubular main body that can be inserted into a blood vessel of a patient; and a first opening that is formed at a position spaced by a predetermined distance from a distal end portion of the main body, is formed so as to be inclined from a distal end side toward a proximal end side of the main body, and is configured to send oxygen-added blood flowing inside the main body into the blood vessel of the patient.SELECTED DRAWING: Figure 4

The present disclosure relates to intracorporeal gas exchange systems and methods in conditions associated with hypoxia and hypercarbia. The present disclosure envisages an intracorporeal oxygenation system comprising a blood oxygenator having a blood compartment and a gas compartment. The blood and gas compartments are separated by a gas permeable barrier so as to allow exchange of carbon dioxide in blood in the blood compartment with oxygen in the gas compartment. The system comprises a catheter device for insertion in a blood vessel of human comprising an interior portion and an exterior portion wherein the interior portion (100a) comprises an annular housing, a plurality of capillary conduit, a pumping device, an air sensing device, a blood sensor and a collar. The present disclosure also relates to a method of oxygenating a deoxygenated blood in a human and also to a method for treating a human suffering from hypoxia or hypercarbia.

A medical device includes an elongated member configured to be inserted into a vessel of a patient. The elongated member includes a permeable membrane that defines a wall of the elongated member and a flow channel within the wall. The permeable membrane defines nanopores extending from an exterior surface of the permeable membrane to tire flow channel. Idle nanopores are configured to enable diffusion of a pressurized gas from out of the flow channel and. into a fluid within the vessel. The nanopores are configured to form gas nanobubbles at the exterior surface of the permeable membrane as the pressurized gas diffuses out from the flow channel and into the fluid within the vessel.

A system for priming a fluid system includes a fluid connector configured to interface with a fluid source and a fluid reservoir including a first connector configured to couple with an inflow line of the fluid system, a second connector configured to couple with an outflow line of the fluid system, and a gas release valve. A system for priming a fluid system includes first and second fluid connectors configured to interface with a fluid source, a first connector configured to couple with an inflow line of the fluid system, a second connector configured to couple with an outflow line of the fluid system, and a gas release valve. A method of priming the fluid system includes coupling the first connector with the inflow line, coupling the second connector with the outflow line, coupling the first fluid connector with the fluid source, and elevating the fluid source.

A system for priming a fluid system includes a fluid connector configured to interface with a fluid source and a fluid reservoir including a first connector configured to couple with an inflow line of the fluid system, a second connector configured to couple with an outflow line of the fluid system, and a gas release valve. A system for priming a fluid system includes first and second fluid connectors configured to interface with a fluid source, a first connector configured to couple with an inflow line of the fluid system, a second connector configured to couple with an outflow line of the fluid system, and a gas release valve. A method of priming the fluid system includes coupling the first connector with the inflow line, coupling the second connector with the outflow line, coupling the first fluid connector with the fluid source, and elevating the fluid source.

A foam management system (1000), apparatus (300), and method are disclosed for a foamed blood product, the apparatus comprising an antifoaming device (400) for receiving a pressurized foam (60) from a pressurized foamed blood product, said antifoaming device allowing a gas (68) to be separated from said foam (60), wherein said antifoaming device converts said pressurized foam (60) into said blood product, allowing the blood product to be recovered from said foam (60), substantially without the foam.

A blood oxygenation device includes an oxygen transport liquid for delivering oxygen, a blood distributor for diverting a single stream of blood into a plurality of blood streams, an oxygen transport liquid distributor for diverting a single stream of said oxygen transport liquid into a second plurality of oxygen transport liquid streams, a third plurality of blood droplet generators for generating blood droplets within said oxygen transport liquid, a fourth plurality of blood oxygenation chambers wherein oxygen diffuses from said oxygen transport liquid into blood, and a blood aggregator for combining blood from the fourth plurality of said blood oxygen transport liquids.

A perfusion system for treatment of a patient experiencing at least one medical condition includes a reservoir configured to receive perfusate, a cannula configured to fluidly couple the reservoir to an arterial blood vessel of a mammal through a single entry point, a fluid line fluidly coupling the reservoir to the cannula, a pressure sensor configured to measure pressure along the fluid line, a flow sensor configured to measure a flow rate along the fluid line; and a pulse generation system. The pulse generation system includes a pulse generator configured to generate pulsatile flow of perfusate from the reservoir to the cannula along the fluid line based on one or more signals generated by at least one of the pressure sensor or the flow sensor. The perfusion system is configured to perfuse an entire circulatory system of the mammal to treat a patient experiencing at least one medical condition.

The blood pump-oxygenator system (1; ,...; 10) comprises at least one blood pump (11), at least one oxygenator (20, 21), a blood inlet (80) and a blood outlet (90) connected together to form a circuit operable as a cardiopulmonary bypass system suitable for extracorporeal treatment of patient blood, wherein the first blood pump (11) is configured to deliver blood through the circuit from the patient (P) to the blood inflow port (80), through the oxygenator (20, 21) and out of the blood outflow port (90) back into the patient (P). The system (1; ,...; the device (10) further comprises a recirculation loop (100) arranged between the blood inlet (80) and the blood outlet (90), where the recirculation loop (100) houses a first blood pump (11) and an oxygenator (20, 21), where the first blood pump (11) is configured to circulate at least a portion of the blood in the loop through the recirculation loop (100) such that the blood passes through the oxygenator (20, 21) multiple times, and where the first blood pump (11) is configured to circulate at least a portion of the blood in the loop through the recirculation loop (100). Blood is repeatedly subjected to an exchange of O2 and CO2 in oxygenators (20, 21). At least one first valve (31) is provided between the recirculation loop (100) and the blood flow outlet (90) and is configured to control an amount of blood flowing through the recirculation loop (100).

A perfusion system for treatment of a patient experiencing at least one medical condition includes a reservoir configured to receive perfusate, a cannula configured to fluidly couple the reservoir to an arterial blood vessel of a mammal through a single entry point, a fluid line fluidly coupling the reservoir to the cannula, a pressure sensor configured to measure pressure along the fluid line, a flow sensor configured to measure a flow rate along the fluid line; and a pulse generation system. The pulse generation system includes a pulse generator configured to generate pulsatile flow of perfusate from the reservoir to the cannula along the fluid line based on one or more signals generated by at least one of the pressure sensor or the flow sensor. The perfusion system is configured to perfuse an entire circulatory system of the mammal to treat a patient experiencing at least one medical condition.

This invention is directed to system and methods for the oxygenation of the blood of a patient, comprising an extracorporeal blood circulation path adapted to be coupled to the patient's vascular system, and comprising apparatus for oxygenating blood flowing therein and withdrawing CO2 therefrom, wherein the flow rate of blood flowing in said extracorporeal blood circulation path does not exceed ⅖ of the patient's blood flow. The extracorporeal blood circulation path preferably comprise a cartridge including an oxygenator and at least one cannula.

An improved method and device for improved catheters and / or related technologies. The device generally comprises an improved medical technology. The provided device substantially improves upon catheter-related medical device technology.

A blood oxygenation device includes an oxygen transport liquid for delivering oxygen, a blood distributor for diverting a single stream of blood into a plurality of blood streams, an oxygen transport liquid distributor for diverting a single stream of said oxygen transport liquid into a second plurality of oxygen transport liquid streams, a third plurality of blood droplet generators for generating blood droplets within said oxygen transport liquid, a fourth plurality of blood oxygenation chambers wherein oxygen diffuses from said oxygen transport liquid into blood, and a blood aggregator for combining blood from the fourth plurality of said blood oxygen transport liquids.