80results about "Oxygenators" patented technology

An infusion solution oxygenation device and an infusion solution oxygenation system capable of supplying oxygen to an infusion solution safely, simply, and quickly. An infusion solution oxygenation device includes a catheter connection portion to which a catheter that supplies an oxygen-containing gas to an infusion solution in an infusion solution container is connected, a gas supply unit that supplies the oxygen-containing gas to the catheter connection portion, and a container pressure sensing unit that senses an internal pressure of the infusion solution container, the gas supply unit controlling the supply of the oxygen-containing gas on the basis of the internal pressure of the infusion solution container sensed by the container pressure sensing unit.

A neurovascular catheter is provided, such as for distal neurovascular access or aspiration. The catheter includes an elongate flexible tubular body, having a proximal end, a distal end and a side wall defining a central lumen. The side wall includes a tubular inner liner, a tie layer separated from the central lumen by the inner liner, a helical coil at least partially overlapping the tie layer, and a tubular braid. A first section of adjacent windings of the helical coil can be spaced farther apart from each other than a second section of adjacent windings of the helical coil.

A blood pump-oxygenator system (250A, 250B, 250C) for increasing perfusion and oxygen levels in the body of a patient (P), comprising: a blood inlet (80) and a blood outlet (90) connected to form a circuit operable as a cardiopulmonary bypass system suitable for extracorporeal treatment of the blood of the patient; a first blood pump (11) and a first oxygenator (20), wherein the first blood pump (11) is configured to deliver blood from the patient (P) through the circuit to the blood inflow port (80), through the first oxygenator (20), out of the blood outflow port (90) and back to the patient (P). The system further comprises a second blood pump (13) and a second oxygenator (21), wherein the second blood pump (13) is configured to deliver blood from the patient (P) through the circuit to the blood inflow port (80), through the second oxygenator (20), out of the blood outflow port (90) and back to the patient (P). The circuit comprises a first branch (101) and a second branch (102) arranged in parallel with each other, the first branch (101) accommodating the first blood pump (11) and the first oxygenator (20), and the second branch (102) accommodating the second blood pump (13) and the second oxygenator (21). The system further comprises a pump control unit (290) wherein the first and second blood pumps (11, 13) are configured to be controlled by the pump control unit (290) to increase or decrease the blood flow through the corresponding oxygenator (20, 21) by changing the proportion of the blood flow through the first and second oxygenator (20, 21).

The present disclosure provides systems and methods for controlling gas-enrichment, e.g., oxygen-enrichment, therapy. A portable device (100) includes a pressurized container (102) and actuator (110) for portable delivery of gas-enrichment therapy.

During a first stage of a priming procedure, a priming fluid is conveyed into a spinning membrane separator via a filtrate outlet port so as to convey air out of the spinning membrane separator via an inlet port and a retentate outlet port of the spinning membrane separator. During an optional second stage of the priming procedure, the priming fluid is conveyed into the spinning membrane separator via the inlet port so as to convey air out of the spinning membrane separator via the retentate outlet port. A rotor positioned within a housing of the spinning membrane separator may be rotated with respect to the housing during the first and second stages to force air from within the rotor into an annulus defined between the rotor and the housing for more complete priming of the spinning membrane separator.

The present invention relates to a method by which intravenous fluids, blood or artificial blood containing high levels of mechanically infused dissolved oxygen can be used to maintain appropriate oxygen levels in venous blood to provide short term oxygenation support to a compromised patient or trauma patient. In one aspect, a system and method for oxygenating a biological fluid for a compromised subject or trauma subject in need of oxygenation support to maintain the subject at an appropriate oxygen level is provided, the method comprising: supplying oxygen from an oxygen source; and dissolving an amount of the supplied oxygen into the biological fluid to obtain an oxygen enriched biological fluid.

A method for onsite hemorrhage control in trauma patients using a portable rapid autotransfusion device can involve recovering a first portion of patient blood from an extravascular space into a fluid reservoir of the device. A negative internal pressure can be applied to the blood. The blood can be conditioned, such as by oxygenating and removing carbon dioxide. The conditioned blood can be returned to the patient intravenously at a rate that matches the rate of blood recovery, ensuring that the net volume of returned blood is maintained substantially equal to the net volume of removed blood.

Systems and methods for gas exchange in a patient are provided that use an external circuit to cause oxygenation perfusion in a body cavity (such as an abdomen) of the patient using an inert chemical (e.g., perfluorocarbon), independent of lungs. The external circuit includes components configured to control properties of the chemical, including temperature, flow rate, pressure, oxygenation percentage, and carbon dioxide percentage. The systems also include safety features to reduce a likelihood of injury to the patient. Each of the safety features and the properties of the chemical can be controlled by a healthcare worker, such as a physician, a nurse, or an emergency operator, for a particular patient.

The present disclosure describes intravascular oxygenation systems and methods with one or more of improved oxygen diffusion flux, improved resistance to bubble formation on the surface of non-porous hollow fibers, and reduced size. The systems and methods include a pneumatic inlet coupled to a pneumatic source that provides a gas containing oxygen at a high pressure. A plurality of hollow fiber membranes (HFM) are in pneumatic communication with the pneumatic inlet to receive the gas containing oxygen and with an outlet to exhaust a partially deoxygenated gas. An electronic controller drives the motor to oscillate the plurality of HFMs to cause a diffusive flux of the gas containing oxygen from the plurality of HFMs into a region of interest of a subject. The electronic controller may drive the motor according to an oscillation pattern, which may include a macro-oscillation with superimposed micro-oscillations.

The present invention provides a system for enriching a flowing liquid with a dissolved gas inside a conduit. The system comprises two or more capillaries, each capillary delivering a stream of a gas-enriched liquid to the flowing liquid. The first ends of the capillaries are positioned to form an intersecting angle with respect to the effluent streams such that these streams of gas-enriched liquid collide with each other upon exit from the first ends of the capillaries, effecting localized convective mixing within the larger liquid conduit before these gas-enriched streams are able to come into close contact with the boundary surfaces of the conduit, whereby the gas-enriched liquid mixes with the flowing liquid to form a gas-enriched flowing liquid. In the preferred embodiment, no observable bubbles are formed in the gas-enriched flowing liquid. Methods of making and using such system are also provided.

The present invention relates to a blood pump for unidirectional blood flow and an oxygenation system including the same, and more particularly to an oxygenation system for circulating the body's blood through an oxygenator to supply oxygen to the body from outside the body, and a blood pump for use in the oxygenation system for unidirectional blood flow. A blood pump according to one embodiment of the present invention includes a blood chamber including an outer wall having a gas outlet formed on one side thereof, a bag inserted into the outer wall and having both ends connected to both ends of the outer wall, a pump inlet valve fluidly connected to one end of the blood chamber and blocking the flow of blood into the blood chamber, and a pump outlet valve fluidly connected to the other end of the blood chamber and blocking the flow of blood from the blood chamber.

A catheter includes a catheter body, a first lumen extending through the catheter body, one or more second lumens extending through the catheter body, and two or more capillaries extending from the catheter body and coupled to the second lumens. The first lumen performs at least one of receiving a sample of the blood from a vasculature of the patient or measuring a parameter of the blood. The second lumens receive a gas enriched liquid from a gas enriched liquid source. The capillaries receive the gas enriched liquid from the one or more second lumens and to simultaneously dispense respective streams of the gas enriched liquid directly into the vasculature, such that the streams of the gas enriched liquid intersect and mix with the blood in a region beyond an end of the catheter body and beyond the first lumen.

A blood processing apparatus may include a heat exchanger and a gas exchanger. At least one of the heat exchanger and the gas exchanger may be configured to impart a radial component to blow flow through the heat exchanger and / or gas exchanger. The heat exchanger may be configured to cause blood flow to follow a spiral flow path.

The double-lumen pipeline for arterial drainage of the application comprises a first pipeline, a second pipeline, a first end and a second end of the first pipeline are both open, a balloon is formed around the first pipeline near the second end of the first pipeline, the balloon is connected with a third pipeline, a first end of the third pipeline is located outside the arterial blood vessel, the balloon is inflated to abut on the inner wall of the arterial blood vessel under proper pressure to form a blockage in the arterial blood vessel, blood upstream of the balloon is led out to the outside through the first pipeline under the action of arterial pressure to facilitate corresponding treatment of the led-out blood to obtain treated blood, a first end of the second pipeline is open, a second end of the second pipeline is closed, a side hole is formed on the second pipeline near the second end of the second pipeline, the side hole is close to the downstream of the balloon and far away from the upstream of the balloon, and the treated blood is injected into the second pipeline through the first end of the second pipeline and then injected into the downstream of the balloon through the side hole of the second pipeline.

An arterial cannula for ECMO includes a main arterial cannula with an inner wall and having a first end with a blood outflow port. The first end is intended to be introduced into an artery so as to inject the blood retrogradely into the artery. A retro-perfusion cannula is configured to be translatably movable between a retracted position in the first end of the main arterial cannula and a deployed position at least partly outside the main arterial cannula and opposite the blood outflow port of the main arterial cannula.

Certain embodiments of the invention are directed to methods of adjusting the concentration of one or more electrolytes in a patient's blood using a counter current electrolyte solution.

A system delivers gas-enriched blood or liquid within the vasculature of a patient while partially obstructing a flow of blood within the vasculature of the patient. The system may include a first catheter configured for inserting into a vasculature of a patient to deliver gas-enriched blood or liquid to a region of the vasculature of the patient. The system may include a second catheter configured for inserting into the vasculature of the patient. The second catheter includes lumens and an occlusion structure configured to partially obstruct a flow of blood within the vasculature of the patient while allowing the first catheter to deliver the gas-enriched blood or liquid to the region of the vasculature, and to divert the blood flow to the region where the gas-enriched blood or liquid is delivered.

The invention relates to a device for the controlled in vivo absorption of CO2, comprising a catheter which has a gas-permeable membrane and a CO2-absorbing carrier medium. The invention additionally relates to a set comprising said device and to the device or set for use in the prophylaxis or treatment of diseases of the respiratory system or for use in the induction of hypercapnia in a patient.

A system to oxygenate blood may include an inlet channel configured to receive blood in a first state, a microbubble generation interface coupled to the inlet channel, the microbubble generation interface including a first stream of a first portion of the blood in the first state; and an inlet, coupled to a downstream end of the first stream, configured to provide microbubbles to the blood in the first state to cause the blood to change to a second state, and the system further including an outlet channel downstream of the inlet to flow the blood in the second state.

A foam management system (1000), apparatus (300), and method are disclosed for a foamed blood product , the apparatus comprising an antifoaming device (400) for receiving a pressurized foam (60) from a pressurized foamed blood product, said antifoaming device allowing a gas (68) to be separated from said foam (60), wherein said antifoaming device converts said pressurized foam (60) into said blood product, allowing the blood product to be recovered from said foam (60), substantially without the foam.

An advanced system and methods for treatment of cancer and other diseases including complications from late-stage viral infections by inducing hyperthermia in a patient relying on withdrawing blood from the patient and returning the withdrawn blood to the patient to establish a continuous extracorporeal flow circuit. Blood is heated by passing through the extracorporeal circuit at a controlled rate until a target body core temperature in is achieved. An innovative concept inherent in the instant invention is the incorporation of an ECMO machine to provide oxygenation. Usually, the blood will be subjected to a continuously re-circulating dialysis to balance electrolytes. Additionally, the blood will be subjected to a continuously recirculating regeneration through a carbon sorbent column where toxins and contaminants are removed. The blood temperature is maintained at the target blood temperature for a treatment period, and the blood is cooled after the treatment period has been completed.

The present invention presents a novel oxygenator of the invention provides a revolutionary engineering design and management of the flow regime in a completely different way from the existing and accepted regime in the field of oxygenators, that further lower the risk levels associated with the use of oxygenators and reduces the manufacturing cost. The revolutionary technology is aimed to divert the world of blood oxygenation from the use of technology that relies on a fiber membrane or gas bubbles and causes substantial damage to the patient's blood, towards the use of technology that allows the exchange of gases without a membrane at all and is aimed to reduces risks and improves patient outcome.

The present disclosure provides systems and methods for controlling gas-enrichment, e.g., oxygen-enrichment, therapy. One or more sensors and / or one or more imaging systems may be used to measure or determine one or more physiological parameters of the patient. Feedback regarding one or more physiological parameters or microvascular resistance may be provided for titrating or controlling the gas-enrichment therapy.

This invention relates to a process through which intravenous fluids, blood, or artificial blood containing high-levels of mechanically-injected dissolved oxygen can be used to maintain appropriate oxygen levels in the venous blood and thereby provide short-term oxygenation support for compromised or trauma patients. In one aspect, there is provided a system and process for oxygenating a biological fluid for use in a compromised or a trauma subject in need of oxygenation support to maintain appropriate oxygen levels in the subject, the process comprising: supplying oxygen gas from an oxygen source; and dissolving an amount of the supplied oxygen into a biological fluid to obtain an oxygen enriched biological fluid.

The invention relates to a cooling unit for a heat exchanger, preferably for a heat exchanger integrated in an oxygenator for the purpose of controlling the temperature of blood conveyed in an extracorporeal blood circuit, with a reservoir in which a liquid is stored, a reaction vessel which comprises a reactant and which, in conjunction with the liquid, is able to initiate an endothermal reaction, a functional means which generates a fluidic access between the reservoir and the reaction vessel, and a fluid line which extends at least in part inside the reaction vessel and which has an inlet line and outlet line, which are each connectable or connected in a fluid-tight manner to a hose system of the heat exchanger, and which, together with the hose system of the heat exchanger, forms at least part of a fluid circuit. The invention is characterized in that an expansion tank with an overflow is provided, into which the liquid from the reservoir flows after fluidic access has been generated between reservoir and reaction vessel, in that the overflow constitutes a fluidic connection to the reaction vessel through which a proportion of the stored liquid passes into the reaction vessel in order to initiate the endothermal reaction with the reactant, in that the fluid line is fluidically connected to the expansion tank, into which a remaining proportion of the stored liquid from the reservoir passes, and in that a fluid pump is arranged along the fluid line, by means of which liquid from the expansion tank passes into the fluid line extending at least in part inside the reaction vessel.

According to some embodiments, a system may treat blood outside the body of a patient. The system may include one or more pumps configured to pump blood in a fluid flow path at a collective rate over 5 liters per minute. The system may include one or more heat exchangers operable to heat at least a portion of the blood to a temperature of at least 42 degrees Celsius and to allow the blood to cool one or more degrees following heating. The system may include one or more convection dialysis modules configured to perform convection dialysis on at least a portion of the blood at least after the one or more heat exchangers allow the blood to cool one or more degrees.

The present disclosure provides systems and methods for controlling gas-enrichment, e.g., oxygen-enrichment, therapy. One or more sensors and / or one or more imaging systems may be used to measure or determine one or more physiological parameters of a patient. Feedback regarding the one or more physiological parameters or microvascular resistance may be provided to titrate or control the gas-enrichment therapy.

According to some embodiments, a system may treat blood outside the body of a patient. The system may include one or more pumps configured to draw blood from a patient into a fluid flow path at a rate, for example, of 5-7 liters per minute. The system may include one or more heat exchangers coupled to the fluid flow path and configured to heat the blood, for example, to a temperature above 42 degrees Celsius and below 43.2 degrees Celsius.

A method for onsite hemorrhage control in trauma patients using a portable rapid autotransfusion device can involve recovering a first portion of patient blood from an extravascular space into a fluid reservoir of the device. A negative internal pressure can be applied to the blood. The blood can be conditioned, such as by oxygenating and removing carbon dioxide. The conditioned blood can be returned to the patient intravenously at a rate that matches the rate of blood recovery, ensuring that the net volume of returned blood is maintained substantially equal to the net volume of removed blood.

To provide a catheter that can be reduced in diameter, can reduce a load on the heart, and can effectively deliver oxygenated blood to important organs.SOLUTION: A catheter includes: a tubular main body that can be inserted into a blood vessel of a patient; and a first opening that is formed at a position spaced by a predetermined distance from a distal end portion of the main body, is formed so as to be inclined from a distal end side toward a proximal end side of the main body, and is configured to send oxygen-added blood flowing inside the main body into the blood vessel of the patient.SELECTED DRAWING: Figure 4