An impurity removal device for the production and processing of crude heparin sodium

Abstract

The present invention relates to the technical field of heparin sodium processing, and discloses an impurity removal device for the production and processing of crude heparin sodium, including: a mounting table, on which a screw blade is rotatably mounted, the screw blade is driven to rotate by a driving source, and its edge is slidably matched with the inner wall of a feeding cylinder fixed on the mounting table. In the cross-section view of the present invention, the gap between the outer ring and the inner ring should be in the shape of an inverted right trapezoid, which means that the small intestine will gradually be ground into small pieces during the falling process. By detecting the extracted solution after the impurity removal treatment, larger small intestine pieces contained in the solution can be timely found, so as to adjust the descent of the inner ring, so that the inner ring and the outer ring can grind the small intestine pieces that were not ground in the previous time, avoiding the problem that too many impurities are hidden in the small intestine pieces and cannot be exposed to the extracted solution to be adsorbed by the impurity removal treatment, and ensuring that the extracted solution entering the next process will not affect the purity of the final heparin sodium product.

Description

Technical Field

[0001] The present invention relates to the technical field of heparin sodium processing, and particularly relates to an impurity removing device for the production and processing of crude heparin sodium. Background Art

[0002] Heparin sodium is a glycosaminoglycan anticoagulant drug extracted from porcine intestinal mucosa and is widely used clinically in situations where rapid anticoagulation is required. However, during the extraction process, crude heparin sodium often contains various impurities, including proteins, nucleic acids, and structurally similar chondroitin polysulfates, etc. These impurities not only affect the purity and efficacy of the drug but also cause serious adverse reactions.

[0003] In the production and processing of crude heparin sodium, first, animal mucosa meeting quality standards needs to be selected. Next, the mucosa tissue is broken so that heparin molecules can come into contact with the extraction solution more fully. Then, a specific solution is added for a dissolution reaction to extract heparin from the animal mucosa. Then, during the extraction process, impurity removal is carried out through ion adsorption technology. However, in the existing production and processing of crude heparin sodium, usually, the mucosa tissue is directly broken by a crushing component to form an extraction solution, and then poured into the impurity removal component. However, insufficient crushing results in large particle structures of the mucosa tissue restricting the release of heparin molecules, making impurities unable to be fully exposed in the extraction solution. In this state, after the extraction solution is subjected to ion adsorption impurity removal, only the impurities in the extraction solution can be removed, while the impurities present in the raw materials will enter the next process, ultimately affecting the purity and quality of the heparin sodium product. Based on this, the present invention purposefully provides an impurity removing device for the production and processing of crude heparin sodium that can make the impurities in the raw material solution fully exposed in the extraction solution and be subjected to ion adsorption impurity removal treatment. Summary of the Invention

[0004] The purpose of the present invention is to provide an impurity removing device for the production and processing of crude heparin sodium aiming at the deficiencies of the prior art, so as to solve the technical problem in the prior art that after the raw material solution is crushed, there are still impurities in the raw materials and they cannot be fully exposed in the extraction solution, resulting in poor impurity removal effect.

[0005] The purpose of the present invention can be achieved by the following technical solutions:

[0006] An impurity removing device for the production and processing of crude heparin sodium, comprising:

[0007] An installation platform, on which a screw blade is rotatably installed. The screw blade is driven to rotate by a driving source, and its edge is in sliding fit with the inner wall of a feeding cylinder fixed on the installation platform. The bottom end of the feeding cylinder is communicated with a feeding hopper. An activity sleeve is arranged on the installation platform and sleeved on the outer cylindrical surface of the feeding cylinder. There is a cavity between the activity sleeve and the feeding cylinder. The bottom of the activity sleeve is communicated with a discharge pipe. An impurity removal component is arranged on the feeding cylinder. The impurity removal component is located below the activity sleeve, and its feeding end is matched with the discharge pipe. The discharge end of the impurity removal component is communicated with a reflux pipe and a discharge pipe through a stop three-way valve, and is connected with a detection component. The reflux pipe is communicated with the feeding cylinder;

[0008] An outer ring, which is rotatably installed on the top of the installation platform and driven to rotate by a second driving component. The inner wall of the outer ring is inclined, and the inner radius of the outer ring decreases downward along its axis; and

[0009] An inner ring, which is slidably installed at the top end of the feeding cylinder and located above the activity sleeve. A plurality of convex blades are fixedly installed on the outer cylindrical surface of the inner ring and the inner wall of the outer ring. The inner ring is driven to lift by a first output source arranged inside the feeding cylinder, and there is a gap between the inner ring and the outer ring. The gap is communicated with the cavity. The first output source is connected with the detection component. In the initial state of the inner ring, the horizontal height of the bottom end of the inner ring is higher than the horizontal height of the bottom end of the outer ring.

[0010] As a further scheme of the present invention: The activity sleeve is rotatably installed on the installation platform and driven to rotate by a first driving component. The number of both the impurity removal components and the detection components is multiple. The multiple impurity removal components are arranged circumferentially. Each impurity removal component includes an ion exchange column and a temporary storage tank. The ion exchange column and the temporary storage tank are both fixedly installed on the outer cylindrical surface of the feeding cylinder and communicated with each other. The feeding end of the ion exchange column is communicated with a funnel. The funnel is matched with the discharge pipe. The discharge end of the temporary storage tank is communicated with the reflux pipe and the discharge pipe through a stop three-way valve. A corresponding detection component is fixedly installed in each temporary storage tank.

[0011] As a further scheme of the present invention: The convex blades are arranged obliquely, and the inclination direction of the convex blades on the inner ring is opposite to the inclination direction of the convex blades on the outer ring.

[0012] As a further scheme of the present invention: The bottom plate of the activity sleeve is arranged obliquely, and the discharge pipe is arranged at the position with a lower horizontal height at the bottom of the activity sleeve.

[0013] As a further scheme of the present invention: A plurality of flow dividing rods are fixedly connected to the outer cylindrical surface of the feeding cylinder. The plurality of flow dividing rods are arranged circumferentially and located in the cavity between the activity sleeve and the feeding cylinder.

[0014] As a further solution of the present invention: a telescopic cylinder is slidably sleeved at the bottom end of the discharge pipe, and the telescopic cylinder is driven to lift by a second output source built in the discharge pipe and is in abutting fit with the inner wall of the funnel.

[0015] As a further solution of the present invention: an umbrella-shaped platform is fixedly connected to the top end of the material conveying cylinder, and the edge of the umbrella-shaped platform faces the gap between the inner ring and the outer ring.

[0016] As a further solution of the present invention: a splash-proof cover is fixedly connected to the top surface of the outer ring, the horizontal height of the horizontal section of the splash-proof cover is higher than the discharge end of the material conveying cylinder, and a conical ring is fixedly installed on the splash-proof cover.

[0017] Advantages of the present invention:

[0018] 1. In the present invention, when viewed from the cross-section, the gap between the outer ring and the inner ring should be in the shape of an inverted right-angled trapezoid, which means that the small intestine will gradually be ground into small fragments during the falling process. By detecting the extracted solution after the impurity removal treatment, it is possible to timely detect the larger small intestine fragments contained in the solution, so as to adjust the descent of the inner ring, so that the inner ring and the outer ring can grind the small intestine fragments that were not ground in the previous time, avoiding the problem that too many impurities are hidden in the small intestine fragments and cannot be exposed to the extracted solution for impurity removal treatment to be adsorbed, and ensuring that the extracted solution entering the next process will not affect the purity of the final heparin sodium product;

[0019] 2. In the present invention, through the arrangement of multiple ion exchange columns, an extracted solution can be more finely divided, and multiple groups of extracted solutions can simultaneously perform impurity removal and subsequent detection. While improving the impurity removal efficiency, the qualified solutions after impurity removal can be gradually transported to the next process in a timely manner, avoiding the situation that due to the local presence of larger small intestine fragments in the extracted solution, the impurity removal is unqualified, and then all the extracted solutions enter the next grinding and impurity removal process;

[0020] 3. In the present invention, through the setting that the inclination direction of the raised blades on the inner ring is opposite to the inclination direction of the raised blades on the outer ring, the acting area of the two is larger, and the cutting ability generated by the rotation of the outer ring is also stronger, avoiding the situation of blockage caused by untimely cutting of the small intestine. And compared with the raised blades inclined in a single direction, the raised blades inclined in the reverse direction can better grind the small intestine into fine particles, improving the cutting effect and making the impurities in the raw material solution easier to be exposed, which is beneficial to the subsequent adsorption of impurities in the raw material solution by the ion exchange column. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] The present invention will be further described below with reference to the accompanying drawings.

[0022] Figure 1 is a schematic diagram of the overall structure of the present invention;

[0023] Figure 2 It is a schematic diagram of the split structure of the outer ring in the present invention;

[0024] Figure 3 It is a schematic diagram of the partial cross-sectional structure of the upper part of the material conveying pipe in the present invention;

[0025] Figure 4 It is a schematic diagram of the structure of the material conveying cylinder in the present invention;

[0026] Figure 5 It is a schematic diagram of the structure of the discharge pipe in the present invention.

[0027] In the figure: 1, mounting table; 2, material conveying cylinder; 201, feeding cylinder; 202, umbrella-shaped table; 3, auger blade; 4, inner ring; 5, outer ring; 6, movable sleeve; 7, discharge pipe; 701, telescopic cylinder; 8, ion exchange column; 801, funnel; 9, temporary storage tank; 10, return pipe; 11, discharge pipe; 12, convex blade; 13, shunt rod; 14, splash-proof cover; 15, conical ring. Specific embodiments

[0028] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments in the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts belong to the scope of protection of the present invention.

[0029] Please refer to Figures 1-5 As shown, the present invention is an impurity removal device for the production and processing of crude heparin sodium, including:

[0030] A mounting table 1, on which an auger blade 3 is rotatably installed. The auger blade 3 is driven to rotate by a driving source, and the edge thereof is in sliding fit with the inner wall of the material conveying cylinder 2 fixed on the mounting table 1. The bottom end of the material conveying cylinder 2 is communicated with the feeding cylinder 201. A movable sleeve 6 is arranged on the mounting table 1 and sleeved on the outer circumferential surface of the material conveying cylinder 2. There is a cavity between the movable sleeve 6 and the material conveying cylinder 2. The bottom of the movable sleeve 6 is communicated with the discharge pipe 7. An impurity removal component is arranged on the material conveying cylinder 2. The impurity removal component is located below the movable sleeve 6, and its feeding end is matched with the discharge pipe 7. The discharge end of the impurity removal component is communicated with the return pipe 10 and the discharge pipe 11 through a stop three-way valve, and it is connected with a detection component. The return pipe 10 is communicated with the material conveying cylinder 2;

[0031] An outer ring 5, which is rotatably installed on the top of the mounting table 1 and is driven to rotate by a second driving component. The inner wall of the outer ring 5 is inclined, and the inner radius of the outer ring 5 decreases downward along its axis; and

[0032] Inner ring 4, which is slidably installed at the top of the feeding cylinder 2 and is located above the movable sleeve 6. A plurality of raised blades 12 are fixedly installed on the outer circumferential surface of the inner ring 4 and the inner wall of the outer ring 5. The inner ring 4 is driven to move up and down by a first output source built in the feeding cylinder 2, and there is a gap between it and the outer ring 5. The gap is communicated with the cavity. The first output source is connected to the detection component. In the initial state of the inner ring 4, the horizontal height of the bottom end of the inner ring 4 is higher than the horizontal height of the bottom end of the outer ring 5.

[0033] In one case of this embodiment, the drive source can be selected from components such as servo motors and servo motors, the first output source can be selected from components such as hydraulic rods and electric cylinders, and the second drive component can be selected from components such as pulley assemblies and gear assemblies driven by motors. This embodiment does not make specific limitations here; the detection component includes a PLC control system, an ultraviolet-visible spectrophotometer sensor, a signal transceiver module, etc. The above components are all prior art, and the present invention has not improved them. Therefore, it is not necessary to disclose their specific mechanical structures and circuit structures, which does not affect the integrity of the present invention.

[0034] When this embodiment is actually applied, first, clean small intestine and a certain proportion of water are mixed into a raw material solution, and an appropriate amount of industrial salt is added. The pH value of the raw material solution is adjusted to 8-9. The raw material solution is transported into the feeding cylinder 2 through the feeding cylinder 201, and the raw material solution is vertically transported upward by the auger blade 3 until it gushes out from the top of the feeding cylinder 2 and diffuses around and falls into the gap between the inner ring 4 and the outer ring 5. The outer ring 5 continuously rotates under the action of the second drive component, and the small intestine in the gap will be continuously cut and broken by the raised blades 12. At this time, the inner ring 4 is in the initial state, and the inner wall of the outer ring 5 is inclined. From the cross-section, the gap between the outer ring 5 and the inner ring 4 should be in the shape of an inverted right trapezoid, which means that the small intestine will be gradually ground into small pieces during the falling process;

[0035] The ground raw material solution drops into the movable sleeve 6. At this time, the extraction solution in the movable sleeve 6 contains the impurities exposed by the ground small intestine. Subsequently, the extraction solution is transported into the impurity removal component through the discharge pipe 7 for impurity removal. The extracted solution after impurity removal is detected by the detection component to check whether the impurities in the extraction solution exceed the threshold and whether the small intestine fragments are larger than the threshold. If both detection results are less than the threshold, the discharge pipe 11 is opened through the three-way stop valve, and the reflux pipe 10 is closed to transport the qualified extraction solution to the next process; otherwise, the reflux pipe 10 is opened, the discharge pipe 11 is closed, and the unqualified extraction solution is transported back into the feeding cylinder 2. And the detection component will control the first output source to lower the inner ring 4, which means that the gap between the bottom ends of the inner ring 4 and the outer ring 5 will decrease. During the next grinding process, the larger small intestine fragments will be ground more thoroughly, so that the impurities in the small intestine are exposed to the extraction solution until both detections are qualified in a certain time, and then it can be transported to the next process.

[0036] As Figure 3 shown, as a preferred embodiment of the present invention, the movable sleeve 6 is rotatably installed on the mounting table 1 and is driven to rotate by a first driving component. The number of both the impurity removal components and the detection components is multiple. The multiple impurity removal components are arranged circumferentially. Each impurity removal component includes an ion exchange column 8 and a storage tank 9. The ion exchange column 8 and the storage tank 9 are both fixedly installed on the outer circumferential surface of the feeding cylinder 2 and are connected to each other. The feeding end of the ion exchange column 8 is connected to the funnel 801, and the funnel 801 cooperates with the discharge pipe 7. The discharge end of the storage tank 9 is connected to the reflux pipe 10 and the discharge pipe 11 through a stop three-way valve. A corresponding detection component is fixedly installed in each storage tank 9.

[0037] In one case of this embodiment, the first driving component can be a pulley component, a gear component driven by a motor, etc., and specific limitations are not made in this embodiment.

[0038] In the actual application of this embodiment, the rotation of the movable sleeve 6 will continuously stir and mix the ground extraction solution, making the impurities more fully exposed in the extraction solution. And when the discharge pipe 7 is aligned with the funnel 801 in turn, the extraction solution is injected into the ion exchange column 8. The solution after ion adsorption is injected into the storage tank 9 for temporary storage. During this period, the detection component detects whether the extraction solution meets the standard. In this way, through the setting of multiple ion exchange columns 8, a portion of the extraction solution can be more finely divided. Multiple groups of extraction solutions can perform impurity removal and subsequent detection simultaneously, improving the impurity removal efficiency and gradually transporting the qualified solution to the next process in a timely manner, avoiding all the extraction solutions entering the next grinding and impurity removal process due to poor local impurity removal effect.

[0039] As Figure 3As shown, as a preferred embodiment of the present invention, the convex blade 12 is arranged obliquely, and the inclination direction of the convex blade 12 on the inner ring 4 is opposite to that of the convex blade 12 on the outer ring 5.

[0040] In actual application of this embodiment, due to the opposite inclination directions of the convex blades 12 on the inner ring 4 and the convex blades 12 on the outer ring 5, the acting areas of the two are larger, and the cutting ability generated by the rotation of the outer ring 5 is also stronger, avoiding the situation of blockage caused by untimely cutting of the small intestine. Moreover, compared with the convex blades 12 inclined in a single direction, the convex blades 12 inclined in the reverse direction can better crush the small intestine into fine particles, improving the cutting effect and making the impurities in the raw material solution easier to be exposed, which is beneficial to the subsequent adsorption of impurities in the extraction solution by the ion exchange column 8.

[0041] As Figures 2-3 shown, as a preferred embodiment of the present invention, the bottom plate of the movable sleeve 6 is arranged obliquely, and the discharge pipe 7 is arranged at a lower horizontal height at the bottom of the movable sleeve 6.

[0042] In actual application of this embodiment, due to the oblique arrangement of the bottom plate of the movable sleeve 6, the extraction solution falling into the movable sleeve 6 will be concentrated at the lower horizontal height. At the same time, the discharge pipe 7 is arranged at the lower horizontal height at the bottom of the movable sleeve 6, so that it is convenient for the extraction solution to be discharged through the discharge pipe 7, avoiding the situation that the extraction solution is likely to remain on the bottom plate of the movable sleeve 6 when the horizontal bottom plate is arranged.

[0043] As Figures 2-3 shown, as a preferred embodiment of the present invention, a plurality of flow dividing rods 13 are fixedly connected to the outer cylindrical surface of the feeding cylinder 2, and the plurality of flow dividing rods 13 are arranged in a circumferential arrangement and are located in the cavity between the movable sleeve 6 and the feeding cylinder 2.

[0044] In actual application of this embodiment, since the rotation of the movable sleeve 6 will drive the extraction solution inside it to tumble and mix, and the flow dividing rods 13 are installed on the outer cylindrical surface of the feeding cylinder 2, the extraction solution will hit the flow dividing rods 13 when tumbling, so that the extraction solution will be cut by the flow dividing rods 13, further achieving the effect of breaking out the impurities in the extraction solution, and at the same time improving the mixing degree of the extraction solution, thereby improving the efficiency of the ion exchange column 8 in removing impurities from the uniformly mixed extraction solution.

[0045] As Figure 5 shown, as a preferred embodiment of the present invention, the bottom end of the discharge pipe 7 is slidably sleeved with a telescopic cylinder 701, and the telescopic cylinder 701 is driven to lift by a second output source built in the discharge pipe 7 and is in abutting cooperation with the inner wall of the funnel 801.

[0046] In one case of this embodiment, the second output source can select components such as an electric cylinder or an electric telescopic rod, or other mechanisms capable of realizing lifting motion. This embodiment does not make specific limitations here.

[0047] In the actual application of this embodiment, before opening the discharge pipe 7 and discharging the extraction solution in the movable sleeve 6 into the funnel 801, first control the telescopic cylinder 701 to descend through the second output source, so that the telescopic cylinder 701 slides on the discharge pipe 7, and its bottom end will abut against the inner wall of the funnel 801, thereby establishing a closed connection channel between the discharge pipe 7 and the funnel 801. In this way, the extraction solution is then transported to the funnel 801 through the telescopic cylinder 701, avoiding the situation of material scattering during discharging due to the gap between the telescopic cylinder 701 and the funnel 801.

[0048] As Figures 1-4 shown, as a preferred embodiment of the present invention, an umbrella-shaped platform 202 is fixedly connected to the top end of the material conveying cylinder 2, and the edge of the umbrella-shaped platform 202 faces the gap between the inner ring 4 and the outer ring 5.

[0049] In the actual application of this embodiment, the setting of the umbrella-shaped platform 202 enables the raw material solution to slide down along the inclined surface of the umbrella-shaped platform 202 to the gap between the inner ring 4 and the outer ring 5 when gushing out from the liquid outlet end of the material conveying cylinder 2. And during the sliding process, the dispersion of the raw material solution will be more uniform, avoiding the phenomenon of local aggregation when the raw material solution gushes out.

[0050] As Figures 1-3 shown, as a preferred embodiment of the present invention, a splash-proof cover 14 is fixedly connected to the top surface of the outer ring 5. The horizontal height of the horizontal section of the splash-proof cover 14 is higher than the discharge end of the material conveying cylinder 2, and a conical ring 15 is fixedly installed on the splash-proof cover 14.

[0051] In the actual application of this embodiment, the splash-proof cover 14 can prevent the small intestine from splashing out during the crushing process. And the setting of the conical ring 15 further expands the shielding range, and the raw materials intercepted by the conical ring 15 will slide down along its inner wall to the gap between the inner ring 4 and the outer ring 5.

[0052] Working principle of the present invention: The shredded raw material solution drops into the movable sleeve 6. At this time, the extraction solution in the movable sleeve 6 contains the impurities exposed by the shredded small intestine. Subsequently, the extraction solution is transported to the impurity removal component through the discharge pipe 7 for impurity removal. The extracted solution after impurity removal is detected by the detection component to detect whether the impurities in the extraction solution exceed the threshold and whether the small intestine fragments are larger than the threshold. If both detection results are less than the threshold, the discharge pipe 11 is opened through the three-way stop valve, and the reflux pipe 10 is closed to transport the qualified extraction solution to the next process; otherwise, the reflux pipe 10 is opened, the discharge pipe 11 is closed, and the unqualified extraction solution is transported back to the feeding cylinder 2 again. And the detection component will control the first output source to lower the inner ring 4, which means that the gap between the bottom ends of the inner ring 4 and the outer ring 5 will decrease. During the next shredding process, the larger small intestine fragments will be shredded more thoroughly, so that the impurities in the small intestine are exposed to the extraction solution until both detections are qualified in a certain time and then can be transported to the next process.

[0053] The above has described in detail an embodiment of the present invention, but the described content is only a preferred embodiment of the present invention and cannot be considered as limiting the scope of implementation of the present invention. Any equivalent changes and improvements made within the scope of the application of the present invention shall still fall within the scope covered by the patent of the present invention.

Claims

1. An impurity removal device for the production and processing of crude heparin sodium, characterized in that: include: A mounting platform (1) is provided on which an auger blade (3) is rotatably mounted. The auger blade (3) is driven to rotate by a driving source, and its edge is slidably matched with the inner wall of a feed barrel (2) fixed on the mounting platform (1). The bottom end of the feed barrel (2) is connected to the feed barrel (201). A movable sleeve (6) is provided on the mounting platform (1) and is sleeved on the outer circumferential surface of the feed barrel (2). A cavity exists between the movable sleeve (6) and the feed barrel (2). The bottom of the movable sleeve (6) is connected to the discharge pipe (7). A debris removal component is provided on the feed barrel (2). The debris removal component is located below the movable sleeve (6), and its feed end is matched with the discharge pipe (7). The discharge end of the debris removal component is connected to the return pipe (10) and the discharge pipe (11) through a stop three-way valve, and is connected to the detection component. The return pipe (10) is connected to the feed barrel (2); An outer ring (5) is rotatably mounted on the top of the mounting platform (1) and is driven to rotate by a second driving assembly. The inner wall of the outer ring (5) is designed to be inclined, and the inner radius of the outer ring (5) decreases downward along its axial direction. as well as An inner ring (4) is slidably mounted on the top of the feed barrel (2) and is located above the movable sleeve (6). A plurality of raised blades (12) are fixedly mounted on the outer surface of the inner ring (4) and the inner wall of the outer ring (5). The inner ring (4) is driven to rise and fall by a first output source built into the feed barrel (2). There is a gap between the inner ring (4) and the outer ring (5), and the gap is connected to the cavity. The first output source is connected to the detection component. In the initial state of the inner ring (4), the horizontal height of the bottom end of the inner ring (4) is higher than the horizontal height of the bottom end of the outer ring (5). An umbrella-shaped platform (202) is fixedly connected to the top of the feeding cylinder (2), and the edge of the umbrella-shaped platform (202) faces the gap between the inner circular ring (4) and the outer circular ring (5).

2. The impurity removal device for the production and processing of crude heparin sodium according to claim 1, characterized in that: The movable sleeve (6) is rotatably mounted on the mounting platform (1) and is driven to rotate by the first driving assembly. The impurity removal assembly and the detection assembly are both multiple in number and are arranged circumferentially. Each impurity removal assembly comprises an ion exchange column (8) and a temporary storage tank (9). The ion exchange column (8) and the temporary storage tank (9) are both fixedly mounted on the outer cylindrical surface of the feeding cylinder (2) and are in communication with each other. The feed end of the ion exchange column (8) is in communication with the funnel (801), and the funnel (801) cooperates with the discharge pipe (7). The discharge end of the temporary storage tank (9) is in communication with the reflux pipe (10) and the discharge pipe (11) via a three-way stop valve. A corresponding detection assembly is fixedly mounted in each temporary storage tank (9).

3. The impurity removal device for the production and processing of crude heparin sodium according to claim 1, characterized in that: The raised blades (12) are arranged in an inclined manner, and the inclined direction of the raised blades (12) on the inner ring (4) is opposite to the inclined direction of the raised blades (12) on the outer ring (5).

4. The impurity removal device for the production and processing of crude heparin sodium according to claim 2, characterized in that: The bottom plate of the movable sleeve (6) is arranged obliquely, and the discharge pipe (7) is arranged at a lower level of the bottom of the movable sleeve (6).

5. The impurity removal device for the production and processing of crude heparin sodium according to claim 2, characterized in that: A plurality of diverter rods (13) are fixedly connected to the outer circumferential surface of the material delivery cylinder (2); the plurality of diverter rods (13) are arranged circumferentially and are located in a cavity between the movable sleeve (6) and the material delivery cylinder (2).

6. The impurity removal device for the production and processing of crude heparin sodium according to claim 2, characterized in that: The bottom end of the discharge pipe (7) is slidably sleeved with a telescopic cylinder (701), the telescopic cylinder (701) is driven to rise and fall by a second output source built into the discharge pipe (7), and is in abutment with the inner wall of the funnel (801).

7. The impurity removal device for the production and processing of crude heparin sodium according to claim 1, characterized in that: The top surface of the outer ring (5) is fixedly connected to a splash shield (14), the horizontal section of the splash shield (14) is higher than the discharge end of the feed barrel (2), and a conical ring (15) is fixedly mounted on the splash shield (14).

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