A complete nutritional formula food for special medical purposes and preparation method thereof

Abstract

The present invention relates to a special medical purpose complete nutritional formula food and a preparation method thereof, and relates to the technical field of special medical purpose formula food. The special medical purpose complete nutritional formula food comprises the following components by weight: 35-40 parts of maltodextrin, 22-26 parts of vegetable fat powder, 10-15 parts of isolated whey protein powder, 7-11 parts of concentrated milk protein powder, 4-7 parts of a first compound nutritional enhancer, 4-7 parts of resistant dextrin, 1.5-3 parts of oligofructose, 0.2-0.6 parts of L-carnitine tartrate, etc. The special medical purpose complete nutritional formula food provided by the present invention is mainly aimed at specific target groups such as patients with digestive and absorption dysfunction, patients with chronic diseases such as "three highs", and the elderly, and can not only provide comprehensive and balanced nutritional support, but also meet the special needs of the target population such as chronic disease management, blood sugar control, cardiovascular protection, etc., and bring significant benefits to the health management of the target population.

Description

Technical Field

[0001] The present invention relates to the technical field of special medical purpose formula food, in particular to a special medical purpose complete nutrition formula food and a preparation method thereof. Background Art

[0002] Food for Special Medical Purpose (FSMP), also known as FSMP for short, is a type of formula food specially processed and prepared to meet the special needs of people for nutrients or diets due to complete or partial food restriction, digestion and absorption disorders, metabolic disorders or specific disease states. FSMP is divided into complete nutrition, specific complete nutrition and non-complete nutrition formula food. Among them, complete nutrition formula food can be used as a single source of nutrition to meet the nutritional needs of the target population and has a wider range of uses.

[0003] In recent years, with the aging of the global population and the increasing number of patients with chronic diseases, the market demand for special medical formula foods has been growing. According to statistics, globally, 86% of hospitalized patients are malnourished or at risk of malnutrition, while in Asia, the proportion is about 40%. In addition, elderly people in nursing homes, rehabilitation centers and communities are also generally facing malnutrition problems. Therefore, it is particularly important to develop high-quality FSMPs with comprehensive nutritional support functions. However, although there are many types of FSMP products on the market, there are still insufficient products that meet the specific nutritional needs of the middle-aged and elderly people over 40 years old, especially those with chronic diseases and hospitalized patients. These people not only need comprehensive nutritional support, but also need to take into account their special physiological and pathological conditions, such as the regulation of blood lipids, blood pressure, blood sugar, and possible gastrointestinal absorption disorders. Summary of the invention

[0004] In order to solve the above problems, the present invention provides a complete nutritional formula food for special medical purposes and a preparation method thereof.

[0005] The technical solution provided by the present invention is as follows:

[0006] In a first aspect, the present invention provides a nutritionally complete formula food for special medical purposes, wherein the nutritionally complete formula food for special medical purposes comprises the following components in parts by weight:

[0007] 35-40 parts of maltodextrin, 22-26 parts of vegetable fat powder, 10-15 parts of isolated whey protein powder, 7-11 parts of concentrated milk protein powder, 4-7 parts of the first compound nutritional fortifier, 4-7 parts of resistant dextrin, 1.5-3 parts of oligofructose, 0.2-0.6 parts of L-carnitine tartrate, 0.2-0.6 parts of inositol, 0.2-0.6 parts of choline bitartrate, 0.1-0.5 parts of the second compound nutritional fortifier, 0.001-0.005 parts of the third compound nutritional fortifier, 0.01-0.05 parts of stevioside and 0.2-0.7 parts of food flavor;

[0008] The first compound nutritional enhancer is prepared by compounding sodium citrate, potassium chloride, magnesium carbonate, potassium dihydrogen phosphate, calcium carbonate, sodium chloride, manganese sulfate, zinc gluconate, ferric pyrophosphate, copper sulfate and sodium selenite in a weight ratio of (2.5-3.5): (1.5-2.5): (0.5-1.0): (1.0-1.8): (1.2-2.0): (0.3-0.7): (0.6-1.0): (1.8-2.5): (1.0-1.5): (0.7-1.0): (0.5-0.9);

[0009] The second compound nutritional enhancer is prepared by compounding taurine, L-ascorbic acid, dl-α-tocopherol acetate, niacinamide, potassium iodide, D-calcium pantothenate, vitamin A acetate, cholecalciferol, D-biotin, cyanocobalamin, folic acid, pyridoxine hydrochloride, thiamine hydrochloride, riboflavin and phytonadione in a weight ratio of (1.0-1.5): (0.4-0.7): (0.2-0.5): (1.8-2.2): (1.3-1.6): (0.5-0.9): (2.0-2.5): (3.0-3.5): (2.2-2.6): (1.6-2.0): (0.8-1.2): (0.3-0.5): (1.2-1.8): (0.9-1.4): (2.4-2.8);

[0010] The third compound nutritional enhancer is compounded by mixing chromium chloride and sodium selenate in a weight ratio of (1.2-1.6):1;

[0011] The vegetable fat powder is prepared by using a first sunflower oil, a second sunflower oil, coconut oil, medium-chain triglycerides, linseed oil, an emulsifier and an excipient in a weight ratio of (15-20): (6-10): (3-8): (12-15): (5-9): (1-4): (58-70); the first sunflower oil includes high oleic acid sunflower oil of the product model GXH001 of Golden Dragon Fish Company; the second sunflower oil includes sunflower oil rich in natural vitamin E of the product model CXY02 of COFCO Group; the excipient is composed of maltodextrin and sodium alginate in a weight ratio of (85-90): (10-15); the emulsifier includes Tween-20;

[0012] The preparation method of the vegetable fat powder comprises the following steps:

[0013] The first sunflower seed oil, the second sunflower seed oil, the coconut oil, the medium-chain triglyceride, the linseed oil, the emulsifier and the excipient are mixed by ultrasonic stirring, and then subjected to freeze-thaw cycle treatment to obtain a mixture;

[0014] The mixed material is subjected to shearing, homogenization and emulsification, and then spray-dried to obtain the vegetable fat powder.

[0015] Furthermore, the complete nutritional formula food for special medical purposes comprises the following components in parts by weight:

[0016] 38.1763 parts of maltodextrin, 24.60 parts of vegetable fat powder, 12.10 parts of isolated whey protein powder, 9.20 parts of concentrated milk protein powder, 6.00 parts of the first compound nutritional fortifier, 5.42 parts of resistant dextrin, 2.36 parts of oligofructose, 0.47 parts of L-carnitine tartrate, 0.42 parts of inositol, 0.42 parts of choline bitartrate, 0.30 parts of the second compound nutritional fortifier, 0.0037 parts of the third compound nutritional fortifier, 0.03 parts of stevioside and 0.50 parts of food flavor.

[0017] Furthermore, the first compound nutritional enhancer is prepared by compounding sodium citrate, potassium chloride, magnesium carbonate, potassium dihydrogen phosphate, calcium carbonate, sodium chloride, manganese sulfate, zinc gluconate, ferric pyrophosphate, copper sulfate and sodium selenite in a weight ratio of 2.7:1.8:0.6:1.5:1.5:0.6:0.8:2.1:1.2:0.8:0.7.

[0018] Furthermore, the second compound nutritional enhancer is prepared by compounding taurine, L-ascorbic acid, dl-α-tocopherol acetate, niacinamide, potassium iodide, D-calcium pantothenate, vitamin A acetate, cholecalciferol, D-biotin, cyanocobalamin, folic acid, pyridoxine hydrochloride, thiamine hydrochloride, riboflavin and phytonadione in a weight ratio of 1.3:0.5:0.4:2.0:1.5:0.5:2.2:3.3:2.4:1.8:1.0:0.4:1.5:1.2:2.6.

[0019] Furthermore, the third compound nutritional enhancer is compounded with chromium chloride and sodium selenate in a weight ratio of 1.5:1.

[0020] Furthermore, the working condition parameters of the ultrasonic stirring and mixing include: ultrasonic power of 500-600W, stirring time of 15-25 minutes, stirring speed of 300-500rpm;

[0021] The working condition parameters of the freeze-thaw cycle treatment include: each freezing temperature is -35~-20°C, each freezing time is 30~60 minutes; each thawing temperature is 30~40°C, each thawing time is 90~120 minutes; the number of freeze-thaw cycle treatments is 3~6 times;

[0022] The working condition parameters of the shear homogenization emulsification include: pressure of 5-10 MPa, rotation speed of 2000-3000 rpm, and time of 10-15 minutes;

[0023] The working condition parameters of the spray drying include: an air inlet temperature of 170-185°C and an air outlet temperature of 55-68°C.

[0024] In a second aspect, based on the same inventive concept, the present invention provides a method for preparing the nutritionally complete formula food for special medical purposes according to any one of the first aspects, the preparation method comprising the following steps:

[0025] Mixing maltodextrin, vegetable fat powder, isolated whey protein powder, concentrated milk protein powder and water by ultrasonic stirring to obtain a first mixture;

[0026] The first mixed material is homogenized and then spray-dried to obtain a second mixed material;

[0027] The remaining components are added to the second mixed material and stirred and mixed to obtain the complete nutritional formula food for special medical purposes.

[0028] Furthermore, the working condition parameters of the ultrasonic stirring and mixing include: ultrasonic power of 500~600W, stirring time of 15~25 minutes, stirring speed of 300~500rpm; the working condition parameters of the homogenization treatment include: homogenization pressure of 6~10Mpa, homogenization speed of 2800~3200rpm, and duration of 12~18 minutes; the working condition parameters of the spray drying include: inlet air temperature of 170~185℃, and outlet air temperature of 55~68℃.

[0029] The above technical solution provided by the embodiment of the present invention has at least the following advantages compared with the prior art:

[0030] The present invention provides a complete nutritional formula food for special medical purposes. The complete nutritional formula food for special medical purposes provided by the present invention is mainly aimed at specific target groups such as patients with digestive and absorption dysfunction, patients with chronic diseases such as "three highs", and the elderly. It can not only provide comprehensive and balanced nutritional support, but also meet the special needs of the target groups such as chronic disease management, blood sugar control, cardiovascular protection, etc., bringing significant benefits to the health management of the target groups. Specifically, the complete nutritional formula food for special medical purposes provided by the present invention has the following main characteristics:

[0031] 1. Low glycemic index (GI): For patients with high blood sugar or diabetes, the GI of the product is controlled at around 37 by scientifically adjusting the ratio of dietary fiber to carbohydrates, which helps control blood sugar levels and reduce post-meal blood sugar fluctuations.

[0032] 2. High-quality protein: By optimizing whey protein isolate and concentrated milk protein powder, the protein ingredients are preferably formulated in a ratio of about 12:9 to provide high-quality, easily digestible protein support to help maintain and restore muscle mass, especially suitable for the elderly and hospitalized patients.

[0033] 3. Comprehensive nutrient coverage: Covering more than 36 nutrients, including vitamins, minerals, dietary fiber, etc., providing balanced nutritional support, helping to improve the nutritional status of patients with chronic diseases, enhance immunity and improve the quality of life.

[0034] 4. Convenient usage: The product is in powder form and is easy to prepare. It is suitable for daily use by the middle-aged and elderly people and dietary management of hospitalized patients. It supports long-term use and nutritional supplementation during the rehabilitation process. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the invention and, together with the description, serve to explain the principles of the invention.

[0036] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, for ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative labor.

[0037] Figure 1 The present invention is a flow chart of a method for preparing a nutritionally complete formula food for special medical purposes. DETAILED DESCRIPTION

[0038] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0039] Unless otherwise specified, various raw materials, reagents, instruments and equipment used in the present invention can be purchased from the market or prepared by existing methods.

[0040] In a first aspect, the present invention provides a nutritionally complete formula food for special medical purposes, wherein the nutritionally complete formula food for special medical purposes comprises the following components in parts by weight:

[0041] 35-40 parts of maltodextrin, 22-26 parts of vegetable fat powder, 10-15 parts of isolated whey protein powder, 7-11 parts of concentrated milk protein powder, 4-7 parts of the first compound nutritional fortifier, 4-7 parts of resistant dextrin, 1.5-3 parts of oligofructose, 0.2-0.6 parts of L-carnitine tartrate, 0.2-0.6 parts of inositol, 0.2-0.6 parts of choline bitartrate, 0.1-0.5 parts of the second compound nutritional fortifier, 0.001-0.005 parts of the third compound nutritional fortifier, 0.01-0.05 parts of stevioside and 0.2-0.7 parts of food flavor;

[0042] The first compound nutritional enhancer is prepared by compounding sodium citrate, potassium chloride, magnesium carbonate, potassium dihydrogen phosphate, calcium carbonate, sodium chloride, manganese sulfate, zinc gluconate, ferric pyrophosphate, copper sulfate and sodium selenite in a weight ratio of (2.5-3.5): (1.5-2.5): (0.5-1.0): (1.0-1.8): (1.2-2.0): (0.3-0.7): (0.6-1.0): (1.8-2.5): (1.0-1.5): (0.7-1.0): (0.5-0.9);

[0043] The second compound nutritional enhancer is prepared by compounding taurine, L-ascorbic acid, dl-α-tocopherol acetate, niacinamide, potassium iodide, D-calcium pantothenate, vitamin A acetate, cholecalciferol, D-biotin, cyanocobalamin, folic acid, pyridoxine hydrochloride, thiamine hydrochloride, riboflavin and phytonadione in a weight ratio of (1.0-1.5): (0.4-0.7): (0.2-0.5): (1.8-2.2): (1.3-1.6): (0.5-0.9): (2.0-2.5): (3.0-3.5): (2.2-2.6): (1.6-2.0): (0.8-1.2): (0.3-0.5): (1.2-1.8): (0.9-1.4): (2.4-2.8);

[0044] The third compound nutritional enhancer is compounded by mixing chromium chloride and sodium selenate in a weight ratio of (1.2-1.6):1;

[0045] The vegetable fat powder is prepared by using a first sunflower oil, a second sunflower oil, coconut oil, medium-chain triglycerides, linseed oil, an emulsifier and an excipient in a weight ratio of (15-20): (6-10): (3-8): (12-15): (5-9): (1-4): (58-70); the first sunflower oil includes high oleic acid sunflower oil of the product model GXH001 of Golden Dragon Fish Company; the second sunflower oil includes sunflower oil rich in natural vitamin E of the product model CXY02 of COFCO Group; the excipient is composed of maltodextrin and sodium alginate in a weight ratio of (85-90): (10-15); the emulsifier includes Tween-20;

[0046] The preparation method of the vegetable fat powder comprises the following steps:

[0047] The first sunflower seed oil, the second sunflower seed oil, the coconut oil, the medium-chain triglyceride, the linseed oil, the emulsifier and the excipient are mixed by ultrasonic stirring, and then subjected to freeze-thaw cycle treatment to obtain a mixture;

[0048] The mixed material is subjected to shearing, homogenization and emulsification, and then spray-dried to obtain the vegetable fat powder.

[0049] The present invention provides a complete nutritional formula food for special medical purposes. The complete nutritional formula food for special medical purposes provided by the present invention is mainly aimed at specific target groups such as patients with digestive and absorption dysfunction, patients with chronic diseases such as "three highs", and the elderly. It can not only provide comprehensive and balanced nutritional support, but also meet the special needs of the target groups such as chronic disease management, blood sugar control, cardiovascular protection, etc., and bring significant benefits to the health management of the target groups.

[0050] In some specific embodiments, the first sunflower oil in the present invention can specifically directly adopt the high oleic sunflower oil of Jinlongyu Company, product model GXH001, which has a high oleic acid content and is suitable for special medical purpose foods; the second sunflower oil can specifically directly adopt the sunflower oil produced by COFCO Group, model CXY02, which is rich in natural vitamin E and has good antioxidant properties; the coconut oil can specifically directly adopt the coconut oil of Wilmar International, product model CY02, which is rich in medium-chain fatty acids and easy to digest and absorb; the medium-chain triglycerides can specifically directly adopt the medium-chain triglycerides produced by Wanxiang Denong, model MCT-50, which is an ideal fat source for special medical purpose foods; the flaxseed oil can specifically directly adopt the flaxseed oil produced by Omega Company, product model LN001, which is rich in α-linolenic acid and is conducive to cardiovascular health.

[0051] The invention utilizes an ultrasonic-freeze-thaw combined treatment method to improve the stability of the obtained vegetable fat powder, which is beneficial to prolonging the storage time of the product and ensuring the quality of the product.

[0052] In some specific embodiments, the total weight portion of each component in the nutritionally complete formula food for special medical purposes is 100 portions.

[0053] In some specific embodiments, the vegetable fat powder of the present invention can be directly used as commercially available products such as vegetable fat powder LF003, vegetable fat powder HOWELL-03, etc., or can be homemade according to the existing vegetable fat powder preparation process.

[0054] In some specific embodiments, the complete nutritional formula food for special medical purposes comprises the following components in parts by weight:

[0055] 38.1763 parts of maltodextrin, 24.60 parts of vegetable fat powder, 12.10 parts of isolated whey protein powder, 9.20 parts of concentrated milk protein powder, 6.00 parts of the first compound nutritional fortifier, 5.42 parts of resistant dextrin, 2.36 parts of oligofructose, 0.47 parts of L-carnitine tartrate, 0.42 parts of inositol, 0.42 parts of choline bitartrate, 0.30 parts of the second compound nutritional fortifier, 0.0037 parts of the third compound nutritional fortifier, 0.03 parts of stevioside and 0.50 parts of food flavor.

[0056] In some specific embodiments, the hydrolysis degree (expressed as DE value) of maltodextrin in the present invention is about 10; specifically, commercially available products such as MD10 produced by China Resources Company can be selected.

[0057] In some specific embodiments, the first compound nutritional enhancer is a compound of sodium citrate, potassium chloride, magnesium carbonate, potassium dihydrogen phosphate, calcium carbonate, sodium chloride, manganese sulfate, zinc gluconate, ferric pyrophosphate, copper sulfate and sodium selenite in a weight ratio of 2.7:1.8:0.6:1.5:1.5:0.6:0.8:2.1:1.2:0.8:0.7.

[0058] In some specific embodiments, the second compound nutritional enhancer is a compound of taurine, L-ascorbic acid, dl-α-tocopherol acetate, niacinamide, potassium iodide, D-calcium pantothenate, vitamin A acetate, cholecalciferol, D-biotin, cyanocobalamin, folic acid, pyridoxine hydrochloride, thiamine hydrochloride, riboflavin and phytonadione in a weight ratio of 1.3:0.5:0.4:2.0:1.5:0.5:2.2:3.3:2.4:1.8:1.0:0.4:1.5:1.2:2.6.

[0059] In some specific embodiments, the third compound nutritional enhancer is compounded with chromium chloride and sodium selenate in a weight ratio of 1.5:1.

[0060] In some specific embodiments, the working condition parameters of the ultrasonic stirring and mixing include: ultrasonic power of 500-600W, stirring time of 15-25 minutes, stirring speed of 300-500rpm;

[0061] The working condition parameters of the freeze-thaw cycle treatment include: each freezing temperature is -35~-20°C, each freezing time is 30~60 minutes; each thawing temperature is 30~40°C, each thawing time is 90~120 minutes; the number of freeze-thaw cycle treatments is 3~6 times;

[0062] The working condition parameters of the shear homogenization emulsification include: pressure of 5-10 MPa, rotation speed of 2000-3000 rpm, and time of 10-15 minutes;

[0063] The working condition parameters of the spray drying include: an air inlet temperature of 170-185°C and an air outlet temperature of 55-68°C.

[0064] In a second aspect, based on the same inventive concept, the present invention provides a method for preparing a nutritionally complete formula food for special medical purposes as described in any one of the first aspects, such as Figure 1 As shown, the preparation method comprises the following steps:

[0065] Mixing maltodextrin, vegetable fat powder, isolated whey protein powder, concentrated milk protein powder and water by ultrasonic stirring to obtain a first mixture;

[0066] The first mixed material is homogenized and then spray-dried to obtain a second mixed material;

[0067] The remaining components are added to the second mixed material and stirred and mixed to obtain the complete nutritional formula food for special medical purposes.

[0068] The present invention provides a method for preparing a nutritionally complete formula food for special medical purposes, which is simple to operate, does not require additional specific equipment, and is suitable for batch industrial production. At the same time, the preparation method is implemented based on the nutritionally complete formula food for special medical purposes described in any one of the first aspects, and therefore has at least the beneficial effects of the nutritionally complete formula food for special medical purposes described in any one of the first aspects, which will not be described in detail here.

[0069] In some specific embodiments, the working condition parameters of the ultrasonic stirring and mixing include: ultrasonic power of 500~600W, stirring time of 15~25 minutes, stirring speed of 300~500rpm; the working condition parameters of the homogenization treatment include: homogenization pressure of 6~10Mpa, homogenization speed of 2800~3200rpm, and duration of 12~18 minutes; the working condition parameters of the spray drying include: inlet air temperature of 170~185℃, outlet air temperature of 55~68℃.

[0070] In some specific embodiments, the weight of the added water is 1-2 times the weight of the maltodextrin.

[0071] It should be noted that the raw materials involved in the complete nutritional formula food for special medical purposes and the preparation method thereof provided by the present invention, unless otherwise specified or specified, can be directly commercially available products or homemade according to the preparation process disclosed in the prior art; at the same time, the operating steps and condition parameters involved, unless otherwise specified or specified, can be carried out according to the existing preparation process of the formula food for special medical purposes or using existing equipment, and the present invention document will not describe them one by one.

[0072] The present invention will be further described below in conjunction with specific examples. It should be understood that these examples are intended only to illustrate the present invention and are not intended to limit the scope of the present invention. The experimental methods in the following examples that do not specify specific conditions are usually measured according to national standards. If there is no corresponding national standard, then the conditions recommended by the manufacturer are followed.

[0073] Example 1

[0074] This example provides a nutritionally complete formula food for special medical purposes, which includes the following components by weight:

[0075] 38.1763 parts of maltodextrin, 24.60 parts of vegetable fat powder, 12.10 parts of isolated whey protein powder, 9.20 parts of concentrated milk protein powder, 6.00 parts of the first compound nutritional fortifier, 5.42 parts of resistant dextrin, 2.36 parts of oligofructose, 0.47 parts of L-carnitine tartrate, 0.42 parts of inositol, 0.42 parts of choline bitartrate, 0.30 parts of the second compound nutritional fortifier, 0.0037 parts of the third compound nutritional fortifier, 0.03 parts of steviol glycosides and 0.50 parts of food flavor;

[0076] The vegetable fat powder is prepared by using the first sunflower oil, the second sunflower oil, coconut oil, medium-chain triglycerides, linseed oil, emulsifier and excipient in a weight ratio of 17:9:5:13:7:2:63; the first sunflower oil is the high oleic sunflower oil of the product model GXH001 of Golden Dragon Fish Company; the second sunflower oil is the sunflower oil rich in natural vitamin E of the product model CXY02 of COFCO Group; the excipient is composed of maltodextrin and sodium alginate in a weight ratio of 87:13; the emulsifier is Tween-20; the preparation method specifically comprises the following steps: ultrasonically stirring and mixing the first sunflower oil, the second sunflower oil, the coconut oil, the medium-chain triglycerides, the linseed oil, the emulsifier and the excipient, and then The mixture is subjected to freeze-thaw cycle treatment to obtain a mixture; the mixture is subjected to shear homogenization and emulsification, and then spray drying to obtain the vegetable fat powder; wherein the working condition parameters of the ultrasonic stirring and mixing include: the ultrasonic power is 560W, the stirring time is 20 minutes, and the stirring speed is 400rpm; the working condition parameters of the freeze-thaw cycle treatment include: each freezing temperature is -30°C, each freezing time is 40 minutes; each thawing temperature is 35°C, each thawing time is 120 minutes; the number of freeze-thaw cycle treatments is 5 times; the working condition parameters of the shear homogenization and emulsification include: the pressure is 7Mpa, the speed is 2400rpm, and the time is 12 minutes; the working condition parameters of the spray drying include: the inlet air temperature is 180°C, and the outlet air temperature is 60°C;

[0077] The first compound nutritional enhancer is prepared by compounding sodium citrate, potassium chloride, magnesium carbonate, potassium dihydrogen phosphate, calcium carbonate, sodium chloride, manganese sulfate, zinc gluconate, ferric pyrophosphate, copper sulfate and sodium selenite in a weight ratio of 2.7:1.8:0.6:1.5:1.5:0.6:0.8:2.1:1.2:0.8:0.7;

[0078] The second compound nutritional enhancer is prepared by compounding taurine, L-ascorbic acid, dl-α-tocopherol acetate, niacinamide, potassium iodide, D-calcium pantothenate, vitamin A acetate, cholecalciferol, D-biotin, cyanocobalamin, folic acid, pyridoxine hydrochloride, thiamine hydrochloride, riboflavin and phytonadione in a weight ratio of 1.3:0.5:0.4:2.0:1.5:0.5:2.2:3.3:2.4:1.8:1.0:0.4:1.5:1.2:2.6;

[0079] The third compound nutritional enhancer is compounded by chromium chloride and sodium selenate in a weight ratio of 1.5:1.

[0080] The preparation method of the above-mentioned complete nutritional formula food for special medical purposes comprises the following steps:

[0081] Mixing maltodextrin, vegetable fat powder, isolated whey protein powder, concentrated milk protein powder and water by ultrasonic stirring to obtain a first mixture;

[0082] The first mixed material is homogenized and then spray-dried to obtain a second mixed material;

[0083] Adding the remaining components to the second mixed material and stirring and mixing them to obtain the complete nutritional formula food for special medical purposes;

[0084] Among them, the working condition parameters of the ultrasonic stirring and mixing include: ultrasonic power of 540W, stirring time of 20 minutes, stirring speed of 400rpm; the working condition parameters of the homogenization treatment include: homogenization pressure of 8Mpa, homogenization speed of 3000rpm, duration of 16 minutes; the working condition parameters of the spray drying include: inlet air temperature of 180°C, outlet air temperature of 62°C; the weight of the added water is 1.5 times the weight of maltodextrin.

[0085] Example 2

[0086] This example provides a nutritionally complete formula food for special medical purposes, which includes the following components by weight:

[0087] 35 parts of maltodextrin, 22 parts of vegetable fat powder, 10 parts of isolated whey protein powder, 7 parts of concentrated milk protein powder, 4 parts of the first compound nutritional fortifier, 4 parts of resistant dextrin, 1.5 parts of oligofructose, 0.2 parts of L-carnitine tartrate, 0.2 parts of inositol, 0.6 parts of choline bitartrate, 0.5 parts of the second compound nutritional fortifier, 0.005 parts of the third compound nutritional fortifier, 0.05 parts of steviol glycosides and 0.2 parts of food flavor;

[0088] The vegetable fat powder is prepared by using the first sunflower oil, the second sunflower oil, coconut oil, medium-chain triglycerides, linseed oil, emulsifier and excipient in a weight ratio of 15:6:3:12:5:1:58; the first sunflower oil is the high oleic acid sunflower oil of the product model GXH001 of Golden Dragon Fish Company; the second sunflower oil is the sunflower oil rich in natural vitamin E of the product model CXY02 of COFCO Group; the excipient is composed of maltodextrin and sodium alginate in a weight ratio of 85:15; the emulsifier is Tween-20; the preparation method specifically comprises the following steps: ultrasonically stirring and mixing the first sunflower oil, the second sunflower oil, the coconut oil, the medium-chain triglycerides, the linseed oil, the emulsifier and the excipient, and then The mixture is subjected to freeze-thaw cycle treatment to obtain a mixture; the mixture is subjected to shear homogenization and emulsification, and then spray drying to obtain the vegetable fat powder; wherein the working condition parameters of the ultrasonic stirring and mixing include: the ultrasonic power is 500W, the stirring time is 25 minutes, and the stirring speed is 300rpm; the working condition parameters of the freeze-thaw cycle treatment include: each freezing temperature is -35°C, each freezing time is 30 minutes; each thawing temperature is 30°C, each thawing time is 120 minutes; the number of freeze-thaw cycle treatments is 5 times; the working condition parameters of the shear homogenization and emulsification include: the pressure is 5Mpa, the speed is 2000rpm, and the time is 15 minutes; the working condition parameters of the spray drying include: the inlet air temperature is 170°C, and the outlet air temperature is 55°C;

[0089] The first compound nutritional enhancer is prepared by compounding sodium citrate, potassium chloride, magnesium carbonate, potassium dihydrogen phosphate, calcium carbonate, sodium chloride, manganese sulfate, zinc gluconate, ferric pyrophosphate, copper sulfate and sodium selenite in a weight ratio of 2.5:1.5:1.0:1.8:2.0:0.3:0.6:1.8:1.0:0.7:0.5;

[0090] The second compound nutritional enhancer is prepared by compounding taurine, L-ascorbic acid, dl-α-tocopherol acetate, niacinamide, potassium iodide, D-calcium pantothenate, vitamin A acetate, cholecalciferol, D-biotin, cyanocobalamin, folic acid, pyridoxine hydrochloride, thiamine hydrochloride, riboflavin and phytonadione in a weight ratio of 1.5:0.4:0.2:1.8:1.3:0.9:2.5:3.0:2.2:1.6:0.8:0.3:1.2:0.9:2.4;

[0091] The third compound nutritional enhancer is compounded by chromium chloride and sodium selenate in a weight ratio of 1.5:1.

[0092] The preparation method of the above-mentioned complete nutritional formula food for special medical purposes is different from that of Example 1 only in that: the working condition parameters of the ultrasonic stirring and mixing include: ultrasonic power of 500W, stirring time of 15 minutes, and stirring speed of 500rpm; the working condition parameters of the homogenization treatment include: homogenization pressure of 6Mpa, homogenization speed of 2800rpm, and duration of 18 minutes; the working condition parameters of the spray drying include: inlet air temperature of 170°C, outlet air temperature of 55°C; the weight of the added water is 1 times the weight of maltodextrin.

[0093] Example 3

[0094] This example provides a nutritionally complete formula food for special medical purposes, which includes the following components by weight:

[0095] 40 parts of maltodextrin, 26 parts of vegetable fat powder, 15 parts of isolated whey protein powder, 11 parts of concentrated milk protein powder, 7 parts of the first compound nutritional fortifier, 7 parts of resistant dextrin, 3 parts of oligofructose, 0.6 parts of L-carnitine tartrate, 0.6 parts of inositol, 0.2 parts of choline bitartrate, 0.1 parts of the second compound nutritional fortifier, 0.001 parts of the third compound nutritional fortifier, 0.01 parts of steviol glycosides and 0.7 parts of food flavor;

[0096] The vegetable fat powder is prepared by using the first sunflower oil, the second sunflower oil, coconut oil, medium-chain triglycerides, linseed oil, emulsifier and excipient in a weight ratio of 20:10:8:15:9:4:70; the first sunflower oil is the high oleic acid sunflower oil of Golden Dragon Fish Company with product model GXH001; the second sunflower oil is the sunflower oil rich in natural vitamin E with product model CXY02 of COFCO Group; the excipient is composed of maltodextrin and sodium alginate in a weight ratio of 90:10; the emulsifier is Tween-20; the preparation method specifically comprises the following steps: ultrasonically stirring and mixing the first sunflower oil, the second sunflower oil, the coconut oil, the medium-chain triglycerides, the linseed oil, the emulsifier and the excipient, and then The mixture is subjected to freeze-thaw cycle treatment to obtain a mixture; the mixture is subjected to shear homogenization and emulsification, and then spray drying to obtain the vegetable fat powder; wherein the working condition parameters of the ultrasonic stirring and mixing include: the ultrasonic power is 600W, the stirring time is 15 minutes, and the stirring speed is 500rpm; the working condition parameters of the freeze-thaw cycle treatment include: each freezing temperature is -20°C, each freezing time is 60 minutes; each thawing temperature is 40°C, each thawing time is 120 minutes; the number of freeze-thaw cycle treatments is 5 times; the working condition parameters of the shear homogenization and emulsification include: the pressure is 10Mpa, the speed is 3000rpm, and the time is 10 minutes; the working condition parameters of the spray drying include: the inlet air temperature is 185°C, and the outlet air temperature is 68°C;

[0097] The first compound nutritional enhancer is prepared by compounding sodium citrate, potassium chloride, magnesium carbonate, potassium dihydrogen phosphate, calcium carbonate, sodium chloride, manganese sulfate, zinc gluconate, ferric pyrophosphate, copper sulfate and sodium selenite in a weight ratio of 3.5:2.5:0.5:1.0:1.2:0.7:1.0:2.5:1.5:1.0:0.9;

[0098] The second compound nutritional enhancer is prepared by compounding taurine, L-ascorbic acid, dl-α-tocopherol acetate, niacinamide, potassium iodide, D-calcium pantothenate, vitamin A acetate, cholecalciferol, D-biotin, cyanocobalamin, folic acid, pyridoxine hydrochloride, thiamine hydrochloride, riboflavin and phytonadione in a weight ratio of 1.0:0.7:0.5:2.2:1.6:0.6:2.0:3.5:2.6:2.0:1.2:0.5:1.8:1.4:2.8;

[0099] The third compound nutritional enhancer is compounded by chromium chloride and sodium selenate in a weight ratio of 1.5:1.

[0100] The preparation method of the above-mentioned complete nutritional formula food for special medical purposes is different from that of Example 1 only in that: the working condition parameters of the ultrasonic stirring and mixing include: ultrasonic power of 600W, stirring time of 25 minutes, and stirring speed of 300rpm; the working condition parameters of the homogenization treatment include: homogenization pressure of 10Mpa, homogenization speed of 3200rpm, and duration of 12 minutes; the working condition parameters of the spray drying include: inlet air temperature of 185°C, outlet air temperature of 68°C; the weight of the added water is 1 times the weight of maltodextrin.

[0101] Example 4

[0102] This example provides a complete nutritional formula food for special medical purposes and a preparation method thereof, which is different from Example 1 only in that the vegetable fat powder is prepared using high oleic sunflower oil, coconut oil, medium chain triglycerides, linseed oil, emulsifier and excipient in a weight ratio of 26:5:13:7:2:63; the remaining steps and parameters are the same.

[0103] Comparative Example 1

[0104] This example provides a vegetable fat powder and a preparation method thereof, which is different from the vegetable fat powder in Example 1 only in that no ultrasonic treatment is performed; the remaining steps and parameters are the same.

[0105] The preparation method of the above-mentioned vegetable fat powder includes the following processes: stirring and mixing the first sunflower oil, the second sunflower oil, coconut oil, medium-chain triglycerides, linseed oil, an emulsifier and an excipient, and then performing a freeze-thaw cycle treatment to obtain a mixture; shearing homogenization emulsification of the mixture, and then spray drying to obtain the vegetable fat powder; wherein the working condition parameters of the stirring and mixing include: a stirring time of 20 minutes, a stirring speed of 400rpm; the working condition parameters of the freeze-thaw cycle treatment include: a freezing temperature of -30°C each time, and a freezing time of 40 minutes each time; a thawing temperature of 35°C each time, and a thawing time of 120 minutes each time; the number of freeze-thaw cycle treatments is 5 times; the working condition parameters of the shear homogenization emulsification include: a pressure of 7Mpa, a rotation speed of 2400rpm, and a time of 12 minutes; the working condition parameters of the spray drying include: an air inlet temperature of 180°C and an air outlet temperature of 60°C.

[0106] Comparative Example 2

[0107] This example provides a vegetable fat powder and a preparation method thereof, which is different from the vegetable fat powder in Example 1 only in that no freeze-thaw cycle treatment is performed; the remaining steps and parameters are the same.

[0108] The preparation method of the vegetable fat powder comprises the following processes: ultrasonically stirring and mixing the first sunflower oil, the second sunflower oil, the coconut oil, the medium-chain triglyceride, the linseed oil, the emulsifier and the excipient to obtain a mixture; shearing homogenization and emulsification of the mixture, and then spray drying to obtain the vegetable fat powder; wherein the working condition parameters of the ultrasonic stirring and mixing include: ultrasonic power of 560W, stirring time of 20 minutes, and stirring speed of 400rpm; the working condition parameters of the shear homogenization and emulsification include: pressure of 7Mpa, speed of 2400rpm, and time of 12 minutes; the working condition parameters of the spray drying include: air inlet temperature of 180°C and air outlet temperature of 60°C.

[0109] Test Example 1

[0110] This example aims to evaluate the stability of the vegetable fat powder in Example 1 and Comparative Examples 1-2.

[0111] Test method: At a temperature of 28°C, add 100g of the vegetable fat powder test sample into 500mL of water and stir for 30 minutes to form a mixture; then let the mixture stand for 48 hours to observe whether the mixture has oil floating or stratification.

[0112] The test results are shown in Table 1.

[0113] Table 1 Stability test results of vegetable fat powder

[0114]

[0115] It can be seen from Table 1 that, compared with Comparative Examples 1-2, Example 1 of the present invention utilizes an ultrasound-freeze-thaw combined treatment method to improve the stability of the obtained vegetable fat powder.

[0116] Test Example 2

[0117] This example uses a rat model with digestive and absorption disorders, hyperglycemia, and hyperlipidemia symptoms to simulate the chronic disease state of humans, aiming to evaluate the effects of the special medical purpose complete nutrition formula foods provided in Examples 1 to 4 on regulating blood sugar and blood lipid levels.

[0118] 1. Experimental Materials

[0119] Experimental subjects: Rat models with symptoms of hyperglycemia and hyperlipidemia;

[0120] Formula samples: samples of complete nutritional formula foods for special medical purposes provided in Examples 1 to 4;

[0121] Control group: Ordinary rat feed, used for control experiments.

[0122] 2. Experimental Design

[0123] The experimental subjects were divided into 5 groups, a control group and 4 experimental groups, with 10 rats in each group; the control group was given ordinary rat feed for control experiments, and each experimental group was given an equal amount of special medical purpose complete nutrition formula food sample every day, and their health status was monitored for 8 weeks, focusing on indicators such as blood sugar, blood lipids, digestive function, and weight changes.

[0124] 3. Test data processing

[0125] Blood glucose level test and blood lipid level test were carried out before and after the experiment, and the blood glucose level decrease rate (%) and blood lipid level decrease rate (%) before and after the experiment were counted and calculated. The test results are shown in Table 2; Note: “-” in Table 2 should be understood as no significant difference in the test results of the index changes before and after the test.

[0126] Table 2

[0127]

[0128] The above test data indicate that the complete nutritional formula food for special medical purposes provided by the embodiments of the present invention can effectively improve and regulate blood sugar and blood lipid levels, and is particularly suitable for patients with chronic diseases and the elderly.

[0129] To sum up, the present invention provides a complete nutritional formula food for special medical purposes and a preparation method thereof. The complete nutritional formula food for special medical purposes provided by the present invention is mainly aimed at specific target groups such as patients with digestive and absorption dysfunction, patients with chronic diseases such as "three highs", and the elderly. It can not only provide comprehensive and balanced nutritional support, but also meet the special needs of the target groups such as chronic disease management, blood sugar control, cardiovascular protection, etc., and bring significant benefits to the health management of the target groups.

[0130] Various embodiments of the present invention may be presented in the form of a range; it should be understood that the description in the form of a range is only for convenience and brevity, and should not be understood as a rigid limitation on the scope of the present invention; therefore, the range description should be considered to have specifically disclosed all possible sub-ranges and single numerical values ​​within the range. For example, the range description from 1 to 6 should be considered to have specifically disclosed sub-ranges, such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6, etc., as well as single numbers within the range, such as 1, 2, 3, 4, 5 and 6, which are applicable regardless of the range. In addition, whenever a numerical range is indicated herein, it is intended to include any cited number (fractional or integer) within the indicated range.

[0131] The foregoing is merely a specific embodiment of the present invention, which enables those skilled in the art to understand or implement the present invention. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features claimed herein.

Claims

1. A nutritionally complete food for special medical purposes, characterized in that: The complete nutritional formula food for special medical purposes comprises the following components in parts by weight: 35-40 parts of maltodextrin, 22-26 parts of vegetable fat powder, 10-15 parts of isolated whey protein powder, 7-11 parts of concentrated milk protein powder, 4-7 parts of the first compound nutritional fortifier, 4-7 parts of resistant dextrin, 1.5-3 parts of oligofructose, 0.2-0.6 parts of L-carnitine tartrate, 0.2-0.6 parts of inositol, 0.2-0.6 parts of choline bitartrate, 0.1-0.5 parts of the second compound nutritional fortifier, 0.001-0.005 parts of the third compound nutritional fortifier, 0.01-0.05 parts of stevioside and 0.2-0.7 parts of food flavor; The first compound nutritional enhancer is prepared by compounding sodium citrate, potassium chloride, magnesium carbonate, potassium dihydrogen phosphate, calcium carbonate, sodium chloride, manganese sulfate, zinc gluconate, ferric pyrophosphate, copper sulfate and sodium selenite in a weight ratio of (2.5-3.5): (1.5-2.5): (0.5-1.0): (1.0-1.8): (1.2-2.0): (0.3-0.7): (0.6-1.0): (1.8-2.5): (1.0-1.5): (0.7-1.0): (0.5-0.9); The second compound nutritional enhancer is prepared by compounding taurine, L-ascorbic acid, dl-α-tocopherol acetate, niacinamide, potassium iodide, D-calcium pantothenate, vitamin A acetate, cholecalciferol, D-biotin, cyanocobalamin, folic acid, pyridoxine hydrochloride, thiamine hydrochloride, riboflavin and phytonadione in a weight ratio of (1.0-1.5): (0.4-0.7): (0.2-0.5): (1.8-2.2): (1.3-1.6): (0.5-0.9): (2.0-2.5): (3.0-3.5): (2.2-2.6): (1.6-2.0): (0.8-1.2): (0.3-0.5): (1.2-1.8): (0.9-1.4): (2.4-2.8); The third compound nutritional enhancer is compounded by mixing chromium chloride and sodium selenate in a weight ratio of (1.2-1.6):1; The vegetable fat powder is prepared by using a first sunflower oil, a second sunflower oil, coconut oil, medium-chain triglycerides, linseed oil, an emulsifier and an excipient in a weight ratio of (15-20): (6-10): (3-8): (12-15): (5-9): (1-4): (58-70); the first sunflower oil includes high oleic acid sunflower oil of the product model GXH001 of Golden Dragon Fish Company; the second sunflower oil includes sunflower oil rich in natural vitamin E of the product model CXY02 of COFCO Group; the excipient is composed of maltodextrin and sodium alginate in a weight ratio of (85-90): (10-15); the emulsifier includes Tween-20; The preparation method of the vegetable fat powder comprises the following steps: The first sunflower seed oil, the second sunflower seed oil, the coconut oil, the medium-chain triglyceride, the linseed oil, the emulsifier and the excipient are mixed by ultrasonic stirring, and then subjected to freeze-thaw cycle treatment to obtain a mixture; The mixed material is subjected to shearing, homogenization and emulsification, and then spray-dried to obtain the vegetable fat powder.

2. The nutritionally complete formula food for special medical purposes according to claim 1, characterized in that: The complete nutritional formula food for special medical purposes comprises the following components in parts by weight: 38.1763 parts of maltodextrin, 24.60 parts of vegetable fat powder, 12.10 parts of isolated whey protein powder, 9.20 parts of concentrated milk protein powder, 6.00 parts of the first compound nutritional fortifier, 5.42 parts of resistant dextrin, 2.36 parts of oligofructose, 0.47 parts of L-carnitine tartrate, 0.42 parts of inositol, 0.42 parts of choline bitartrate, 0.30 parts of the second compound nutritional fortifier, 0.0037 parts of the third compound nutritional fortifier, 0.03 parts of stevioside and 0.50 parts of food flavor.

3. The nutritionally complete formula food for special medical purposes according to claim 1, characterized in that: The first compound nutritional enhancer is prepared by compounding sodium citrate, potassium chloride, magnesium carbonate, potassium dihydrogen phosphate, calcium carbonate, sodium chloride, manganese sulfate, zinc gluconate, ferric pyrophosphate, copper sulfate and sodium selenite in a weight ratio of 2.7:1.8:0.6:1.5:1.5:0.6:0.8:2.1:1.2:0.8:0.

7.

4. The nutritionally complete formula food for special medical purposes according to claim 1, characterized in that: The second compound nutritional enhancer is obtained by compounding taurine, L-ascorbic acid, dl-α-tocopherol acetate, niacinamide, potassium iodide, D-calcium pantothenate, vitamin A acetate, cholecalciferol, D-biotin, cyanocobalamin, folic acid, pyridoxine hydrochloride, thiamine hydrochloride, riboflavin and phytonadione in a weight ratio of 1.3:0.5:0.4:2.0:1.5:0.5:2.2:3.3:2.4:1.8:1.0:0.4:1.5:1.2:2.

6.

5. The nutritionally complete formula food for special medical purposes according to claim 1, characterized in that: The third compound nutritional enhancer is compounded by chromium chloride and sodium selenate in a weight ratio of 1.5:

1.

6. The nutritionally complete formula food for special medical purposes according to claim 1, characterized in that: The working condition parameters of the ultrasonic stirring and mixing include: ultrasonic power of 500-600W, stirring time of 15-25 minutes, stirring speed of 300-500rpm; The working condition parameters of the freeze-thaw cycle treatment include: each freezing temperature is -35~-20°C, each freezing time is 30~60 minutes; each thawing temperature is 30~40°C, each thawing time is 90~120 minutes; the number of freeze-thaw cycle treatments is 3~6 times; The working condition parameters of the shear homogenization emulsification include: pressure of 5-10 MPa, rotation speed of 2000-3000 rpm, and time of 10-15 minutes; The working condition parameters of the spray drying include: an air inlet temperature of 170-185°C and an air outlet temperature of 55-68°C.

7. A method for preparing a nutritionally complete formula food for special medical purposes according to any one of claims 1 to 6, characterized in that: The preparation method comprises the following steps: Mixing maltodextrin, vegetable fat powder, isolated whey protein powder, concentrated milk protein powder and water by ultrasonic stirring to obtain a first mixture; The first mixed material is homogenized and then spray-dried to obtain a second mixed material; The remaining components are added to the second mixed material and stirred and mixed to obtain the complete nutritional formula food for special medical purposes.

8. The method for preparing a nutritionally complete formula food for special medical purposes according to claim 7, characterized in that: The working condition parameters of the ultrasonic stirring and mixing include: ultrasonic power of 500-600W, stirring time of 15-25 minutes, stirring speed of 300-500rpm; the working condition parameters of the homogenization treatment include: homogenization pressure of 6-10Mpa, homogenization speed of 2800-3200rpm, and duration of 12-18 minutes; the working condition parameters of the spray drying include: inlet air temperature of 170-185°C, and outlet air temperature of 55-68°C.

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