Preparation method of quantum dots and microfluidic reaction system

Abstract

The invention discloses a preparation method of quantum dots and a microfluidic reaction system. The preparation method of the quantum dot comprises the following steps: providing a precursor solution, wherein the precursor solution comprises a precursor and a first solvent; providing a second solvent, and mixing the second solvent with the precursor solution to obtain quantum dots; wherein the second solvent and the first solvent are mutually soluble, and the second solvent and the precursor are insoluble. The invention provides a novel method for synthesizing quantum dots.

Description

Technical Field

[0001] The present application relates to the field of microfluidic reactions, and in particular to a method for preparing quantum dots and a microfluidic reaction system. Background Art

[0002] The existing preparation process of synthesized quantum dots is relatively complicated. Therefore, the present application aims to provide a novel method for synthesizing quantum dots. Summary of the invention

[0003] The present application provides a novel method for preparing quantum dots and a microfluidic reaction system.

[0004] The present application provides a method for preparing a quantum dot light-emitting device, wherein the quantum dots are prepared using a microfluidic chip, and the preparation method comprises the following steps:

[0005] Providing a precursor solution, wherein the precursor solution comprises a precursor and a first solvent; and

[0006] A second solvent is provided, and the second solvent is mixed with the precursor solution to obtain quantum dots; wherein the second solvent is miscible with the first solvent, and the second solvent is insoluble with the precursor.

[0007] Optionally, in some embodiments of the present application, in the step of mixing the second solvent and the precursor solution, a quantum dot fluid including the quantum dots is obtained after the second solvent and the precursor solution are mixed;

[0008] The preparation method further includes: providing a third solvent, and mixing the third solvent with the quantum dot fluid to obtain quantum dot microdroplets containing the quantum dots; wherein the third solvent is insoluble in the second solvent.

[0009] Optionally, in some embodiments of the present application, before the step of mixing the second solvent and the precursor solution, the preparation method further comprises: injecting the precursor solution into a microfluidic chip;

[0010] The step of mixing the second solvent with the precursor solution comprises: injecting the second solvent into the microfluidic chip; wherein the flow rate ratio of the first solvent to the second solvent in the microfluidic chip is 1:10-1:50;

[0011] The step of mixing the third solvent and the quantum dot fluid comprises: injecting the third solvent into the microfluidic chip; wherein the flow rate ratio of the second solvent to the third solvent in the microfluidic chip is 1:3-1:10.

[0012] Optionally, in some embodiments of the present application, the first solvent includes dimethylformamide and / or dimethyl sulfoxide; and / or

[0013] The second solvent comprises diethyl ether and / or cyclohexane; and / or

[0014] The third solvent includes at least one of dimethyl sulfoxide, acetonitrile and methanol.

[0015] Optionally, in some embodiments of the present application, the first solvent, the second solvent and the third solvent are dimethylformamide, diethyl ether and dimethyl sulfoxide, respectively; or

[0016] The first solvent, the second solvent and the third solvent are dimethylformamide, cyclohexane and acetonitrile in sequence; or

[0017] The first solvent, the second solvent and the third solvent are dimethylformamide, cyclohexane and methanol in sequence; or

[0018] The first solvent, the second solvent and the third solvent are dimethyl sulfoxide, cyclohexane and methanol respectively.

[0019] Optionally, in some embodiments of the present application, before the step of mixing the second solvent and the precursor solution, the preparation method further includes: performing ultrasonic treatment on the precursor solution.

[0020] Optionally, in some embodiments of the present application, the precursor includes a first precursor and a second precursor, the first solvent includes a first sub-solvent and a second sub-solvent, the first sub-solvent and the second sub-solvent are both miscible with the second solvent, the first precursor and the second precursor are different, and the first sub-solvent and the second sub-solvent are the same or different; the precursor solution includes a first precursor solution and a second precursor solution, the first precursor solution includes the first precursor and the first sub-solvent, and the second precursor solution includes the second precursor and the second sub-solvent;

[0021] Before the step of mixing the second solvent and the precursor solution, the preparation method further comprises:

[0022] respectively subjecting the first precursor solution and the second precursor solution to ultrasonic treatment;

[0023] The first precursor solution and the second precursor solution after the ultrasonic treatment are mixed to obtain the precursor solution.

[0024] Optionally, in some embodiments of the present application, after the step of mixing the first precursor solution and the second precursor solution after the ultrasonic treatment, the preparation method further comprises: subjecting the mixed precursor solution to ultraviolet irradiation treatment.

[0025] Optionally, in some embodiments of the present application, after obtaining the quantum dot fluid including the quantum dots, the preparation method further comprises: vacuumizing the quantum dot fluid; and / or

[0026] After obtaining the quantum dot micro-droplets containing the quantum dots, the preparation method further comprises: cooling the quantum dot micro-droplets.

[0027] Optionally, in some embodiments of the present application, before the step of mixing the second solvent and the precursor solution, the preparation method further includes: activating the precursor solution.

[0028] The present application also provides a microfluidic reaction system, which includes a microfluidic chip, and the microfluidic chip includes:

[0029] A first injection channel, used for injecting a precursor solution, wherein the precursor solution includes a precursor and a first solvent;

[0030] a second injection channel for injecting a second solvent, wherein a discharge end of the second injection channel is connected to a discharge end of the first injection channel; wherein the second solvent is miscible with the first solvent and insoluble with the precursor; and

[0031] A reaction channel, wherein the first end of the reaction channel is respectively connected to the discharge end of the first injection channel and the discharge end of the second injection channel, so as to mix the second solvent and the precursor solution to obtain quantum dots.

[0032] Optionally, in some embodiments of the present application, the microfluidic chip further comprises:

[0033] a third injection channel, for injecting a third solvent, the third solvent being insoluble in the second solvent; wherein a discharge end of the third injection channel is connected to the second end of the reaction channel; and

[0034] An outflow channel is used to mix the third solvent and the quantum dot fluid including the quantum dots flowing out from the second end of the reaction channel to obtain quantum dot microdroplets; wherein the feed end of the outflow channel is connected to the discharge end of the third injection channel and the second end of the reaction channel.

[0035] Optionally, in some embodiments of the present application, the microfluidic chip further comprises a mixing channel, a first end of the mixing channel is connected to a discharge end of the first injection channel, and a second end of the mixing channel is connected to a discharge end of the second injection channel and a first end of the reaction channel;

[0036] The first injection channel includes a first sub-injection channel and a second sub-injection channel arranged in parallel, the discharge end of the first sub-injection channel and the discharge end of the second sub-injection channel are connected to form a confluence, and the first end of the mixing channel is connected to the confluence.

[0037] Optionally, in some embodiments of the present application, in the length direction of the microfluidic chip, the ratio of the length of the mixing channel to the length of the microfluidic chip is in the range of 1:3-1:5; and / or

[0038] In the length direction of the microfluidic chip, the ratio of the length of the reaction channel to the length of the microfluidic chip is in the range of 1:10-1:16; and / or

[0039] In the length direction of the microfluidic chip, the ratio of the length of the outflow channel to the length of the microfluidic chip is in the range of 1:2-1:3.

[0040] Optionally, in some embodiments of the present application, the length of the mixing channel is 10cm-15cm; and / or, the length of the reaction channel is 3cm-5cm; and / or, the length of the outflow channel is 15cm-20cm.

[0041] Optionally, in some embodiments of the present application, the inner diameter of the mixing channel is 100 μm-130 μm; and / or, the inner diameter of the reaction channel is 170 μm-220 μm; and / or, the inner diameter of the outflow channel is 260 μm-300 μm.

[0042] Optionally, in some embodiments of the present application, the microfluidic chip further includes an ultrasonic device, and the ultrasonic device is arranged corresponding to the first injection channel; and / or

[0043] The microfluidic reaction system further comprises an ultraviolet irradiation device, and the ultraviolet irradiation device is arranged corresponding to the mixing channel; and / or

[0044] The microfluidic reaction system further comprises a negative pressure device, and the negative pressure device is arranged corresponding to the reaction channel; and / or

[0045] The microfluidic reaction system further comprises a cooling device, and the cooling device is arranged corresponding to the outflow channel.

[0046] The present application provides a method for preparing quantum dots and a microfluidic reaction system. In the method for preparing quantum dots using a microfluidic method provided in the present application, a second solvent is added to a precursor solution, and the difference in solubility of the second solvent in the precursor solution and the first solvent is utilized to synthesize quantum dots, thereby providing a novel method for synthesizing quantum dots. BRIEF DESCRIPTION OF THE DRAWINGS

[0047] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For those skilled in the art, other drawings can be obtained based on these drawings without creative work.

[0048] Figure 1 It is a schematic diagram of the process of preparing quantum dots provided in this application.

[0049] Figure 2 It is a top view of the microfluidic reaction system provided in this application.

[0050] Figure 3 It is a front view of the microfluidic chip provided in this application. DETAILED DESCRIPTION

[0051] The technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without making creative work belong to the scope of protection of the present application. In addition, it should be understood that the specific implementation methods described herein are only used to illustrate and explain the present application, and are not used to limit the present application.

[0052] In this application, unless otherwise stated, directional words such as "upper" and "lower" generally refer to the upper and lower parts of the device in actual use or working state, specifically the drawing direction in the accompanying drawings; while "inner" and "outer" refer to the outline of the device. In addition, in the description of this application, the term "including" means "including but not limited to". The terms first, second, third, etc. are used only as labels and do not impose numerical requirements or establish an order.

[0053] In this application, "and / or" describes the association relationship of associated objects, indicating that there may be three relationships. For example, A and / or B can mean: A exists alone, A and B exist at the same time, and B exists alone. A and B can be singular or plural.

[0054] In the present application, "at least one" means one or more, and "plurality" means two or more. "At least one", "at least one of the following" or similar expressions refer to any combination of these items, including any combination of single items or plural items. For example, "at least one of a, b, or c", or "at least one of a, b, and c" can all mean: a, b, c, ab (i.e., a and b), ac, bc, or abc, where a, b, c can be single or multiple, respectively.

[0055] Various embodiments of the present application may be presented in the form of a range; it should be understood that the description in the form of a range is only for convenience and brevity, and should not be understood as a rigid limitation on the scope of the present application; therefore, the range description should be considered to have specifically disclosed all possible sub-ranges and single numerical values ​​within the range. For example, the range description from 1 to 6 should be considered to have specifically disclosed sub-ranges, such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6, etc., as well as single numbers within the range, such as 1, 2, 3, 4, 5 and 6, which apply regardless of the range. In addition, whenever a numerical range is indicated herein, it is meant to include any cited number (fractional or integer) within the indicated range.

[0056] It can be understood that the microfluidic chip of the present application may refer to a chip that can perform microfluidic reactions, that is, a chip on a micron-scale that integrates channels for containing fluids, mixing units, reaction units and other functional components to control the movement of micron-volume fluids in a tiny space, thereby realizing fluid reactions within the chip to achieve the purpose of continuously preparing products, such as the continuous preparation of nanocrystals such as quantum dots.

[0057] It should be noted that in the present application, the material of the microfluidic chip can be silicon wafer, glass, ceramic, polydimethylsiloxane, polystyrene, polymethyl methacrylate, etc. This application only uses the material of the microfluidic chip as glass as an example for illustration, but it should not be understood as a limitation to the present application.

[0058] The present application provides a method for preparing quantum dots, wherein the quantum dots are prepared using a microfluidic chip. Figure 1 The method for preparing quantum dots provided in the present application comprises the following steps:

[0059] S11: providing a precursor solution, wherein the precursor solution includes a precursor and a first solvent;

[0060] S12: injecting the precursor solution into the microfluidic chip; and

[0061] S13: providing a second solvent, and injecting the second solvent into the microfluidic chip, mixing the second solvent and the precursor solution to obtain quantum dots; the second solvent and the first solvent are mutually soluble, and the second solvent is insoluble in the precursor.

[0062] Therefore, in the method for preparing quantum dots using a microfluidic chip provided in the present application, a second solvent is added to the precursor solution. Since the second solvent is a poor solvent for the precursor in the precursor solution, but is miscible with the first solvent in the precursor solution, the difference in solubility of the second solvent to the precursor and the first solvent is used to synthesize quantum dots, thereby providing a new method for synthesizing quantum dots using a microfluidic chip, which can improve the quality of quantum dots synthesized using a microfluidic method.

[0063] The following is a detailed description of the method for preparing quantum dots provided in this application.

[0064] It should be noted that the quantum dots in the present application can be selected from at least one of single-structure quantum dots and core-shell structure quantum dots. The single-structure quantum dots are selected from at least one of II-VI compounds, III-V compounds and I-III-VI compounds. The II-VI compounds are selected from at least one of CdSe, CdS, CdTe, ZnSe, ZnS, CdTe, ZnTe, CdZnS, CdZnSe, CdZnTe, ZnSeS, ZnSeTe, ZnTeS, CdSeS, CdSeTe, CdTeS, CdZnSeS, CdZnSeTe and CdZnSTe, the III-V compounds are selected from at least one of InP, InAs, GaP, GaAs, GaSb, AlN, AlP, InAsP, InNP, InNSb, GaAlNP and InAlNP, and the I-III-VI compounds are selected from at least one of CuInS2, CuInSe2 and AgInS2. The core of the quantum dot with core-shell structure is selected from any one of the above-mentioned single structure quantum dots, and the shell material of the quantum dot with core-shell structure is selected from at least one of CdS, CdTe, CdSeTe, CdZnSe, CdZnS, CdSeS, ZnSe, ZnSeS and ZnS. In the following embodiments of the present application, only the quantum dots are perovskite quantum dots such as cadmium-based quantum dots as an example for illustration, but it cannot be understood as a limitation of the present application.

[0065] In some embodiments, the precursor in step S11 may include a first precursor and a second precursor, and the first solvent includes a first sub-solvent and a second sub-solvent. The first precursor and the second precursor are different, and the first sub-solvent and the second sub-solvent may be the same or different. The precursor solution in step S11 may be formed by mixing the first precursor solution and the second precursor solution. The first precursor solution includes a first precursor, a first ligand, and a first sub-solvent. The second precursor solution includes a second precursor, a second ligand, and a second sub-solvent.

[0066] It should be noted that the embodiments of the present application are only described by taking the first sub-solvent and the second sub-solvent as the same example (both are the first solvent), that is, the precursor solution includes the first precursor, the second precursor, the first ligand, the second ligand and the first solvent, but this cannot be understood as a limitation of the present application.

[0067] Specifically, the first precursor may include at least one compound containing cadmium, zinc, lead, indium, mercury or gallium, etc. The second precursor may include at least one compound containing selenium, sulfur, tellurium, phosphorus or arsenic, etc.

[0068] The first ligand and the second ligand can be independently selected from at least one of an acid ligand, a thiol ligand, an amine ligand, a (oxygen) phosphine ligand, a phospholipid, a soft phosphine and polyvinyl pyridine, wherein the acid ligand is selected from at least one of deca-acid, undecylenic acid, tetradecanoic acid, oleic acid and stearic acid; the thiol ligand is selected from at least one of octadecyl mercaptan, dodecyl mercaptan and octadecyl mercaptan; the amine ligand is selected from at least one of oleylamine, octadecylamine and octaamine; the (oxygen) phosphine ligand is selected from at least one of trioctylphosphine and trioctylphosphine oxide. The first ligand and the second ligand can be the same or different. In the present application, the first ligand and the second ligand are the same to improve the mixing effect between the first precursor solution and the second precursor solution.

[0069] The first solvent can dissolve the first precursor, the second precursor, the first ligand and the second ligand well. Specifically, the first solvent can be selected from but not limited to at least one of dimethylformamide and dimethyl sulfoxide.

[0070] In some embodiments, before mixing the first precursor solution and the second precursor solution, the method for preparing quantum dots may further include: performing activation treatment on the first precursor solution and the second precursor solution, respectively. Through the above-mentioned activation treatment, while synthesizing quantum dots by utilizing the difference in solubility of the second solvent to the precursor and the first solvent, the present application may also increase the kinetic energy of the first precursor reaction and the kinetic energy of the second precursor reaction, respectively, so as to increase the dissolution rates of the first precursor and the second precursor in the first solvent, respectively.

[0071] In some embodiments, the activation treatment may be performed by electromagnetic heating, wherein the heating temperature of the electromagnetic heating may be set to 80°C-100°C, for example, 80°C, 85°C, 90°C, 95°C or 100°C.

[0072] In some embodiments, before step S12, the method for preparing quantum dots further includes: performing hydrophobic treatment on the channel in the microfluidic chip. On the one hand, the above arrangement can improve the smoothness of the inner wall of the channel of the microfluidic chip to further reduce the probability of bubble generation on the inner wall of the channel; on the other hand, the above arrangement can also reduce the probability of adsorption of the first precursor and the second precursor on the inner wall of the channel of the microfluidic chip, thereby avoiding agglomeration due to the first precursor and the second precursor sticking to the inner wall of the channel.

[0073] In some embodiments, the hydrophobic treatment step may specifically be: first, immerse the microfluidic chip in a washing solution prepared by mixing 30% hydrogen peroxide and 98% sulfuric acid in a volume ratio of 3:7, and heat at 80°C-100°C for 1 hour, and then cool naturally; then, clean the microfluidic chip to remove residual washing solution, wherein pure double distilled water may be used for cleaning; finally, dry the cleaned microfluidic chip to obtain a hydrophobic microfluidic chip.

[0074] In some embodiments, the channels within the microfluidic chip may include an injection channel for injecting a first precursor solution and a second precursor solution, a mixing channel for mixing the first precursor solution and the second precursor solution, a reaction channel for synthesizing quantum dot fluid, an outflow channel for forming quantum dot microdroplets, and the like.

[0075] In some embodiments, step S12 includes: injecting the first precursor solution and the second precursor solution into different injection channels of the microfluidic chip respectively. That is, the mixing of the first precursor solution and the second precursor solution occurs in the microfluidic chip. Compared with mixing before entering the microfluidic chip, since the channels in the microfluidic chip are micro-sized, the above-mentioned setting can improve the mixing uniformity of the first precursor solution and the second precursor solution. The inventors of the present application found in experimental research that in the process of preparing quantum dots using microfluidic chips, due to the difference between the internal air pressure and the external air pressure of the microfluidic chip, when the precursor solution is injected into the microfluidic chip, the precursor solution is easy to generate bubbles in the microfluidic chip, especially, the precursor solution has the highest probability of generating bubbles at the inner wall of the injection channel of the microfluidic chip. The generation of the above-mentioned bubbles will cause the reaction rate and the surface morphology of the quantum dots to change during the synthesis of the quantum dots, thereby reducing the yield and quality of the quantum dots.

[0076] Furthermore, at the location where bubbles are generated inside the microfluidic chip, the precursors in the precursor solution are prone to agglomeration and accumulation inside the microfluidic chip, making the microfluidic chip prone to clogging and scrapping. This will not only lead to the termination of the synthesis reaction of quantum dots, but also cause waste of materials, thereby increasing the process manufacturing cost of quantum dots.

[0077] In view of the above technical problems existing in the prior art, in some embodiments, between step S12 and step S13, the method for preparing quantum dots further includes: ultrasonically treating the precursor solution in the microfluidic chip. Specifically, the first precursor solution and the second precursor solution in different injection channels of the microfluidic chip are ultrasonically treated, and after the ultrasonic treatment, the first precursor solution and the second precursor solution are mixed in the mixing channel of the microfluidic chip to obtain a precursor solution.

[0078] In the synthesis method of quantum dots provided in the present application, through the above-mentioned ultrasonic treatment, while utilizing the difference in solubility of the second solvent to the precursor and the first solvent to synthesize quantum dots, the present application can also reduce the probability of bubble generation in different channels of the first precursor solution and the second precursor solution in the microfluidic chip, respectively, so that in the subsequent synthesis reaction of quantum dots, the reaction rate of the system, the intermediate phase morphology and the surface morphology of the quantum dots can be improved, thereby improving the yield and quality of the quantum dots. In addition, the reduction in the risk of bubble generation will reduce the probability of agglomeration between the first precursor, the second precursor, and the first precursor and the second precursor in the precursor solution, thereby reducing the risk of blockage inside the microfluidic chip, thereby avoiding the increase in process manufacturing costs due to material waste; in addition, the above-mentioned setting can also increase the reaction rate of the first precursor and the second precursor in the subsequent synthesis reaction process, thereby improving the yield and quality of quantum dots.

[0079] Specifically, in the ultrasonic treatment step, the ultrasonic temperature can be set to 80° C.-100° C., for example, 80° C., 85° C., 90° C., 95° C. or 100° C. That is, the ultrasonic temperature of the ultrasonic treatment and the heating temperature of the electromagnetic heating are set in the same temperature range, which can ensure that the quantum dot synthesis reaction system is maintained in a constant temperature range, thereby improving the quality of the synthesized quantum dots.

[0080] In some embodiments, in the process of mixing the first precursor solution and the second precursor solution in the microfluidic chip to obtain the precursor solution, the method for preparing quantum dots further includes the step of: subjecting the precursor solution in the microfluidic chip to ultraviolet irradiation.

[0081] In the method for synthesizing quantum dots provided in the present application, through the above-mentioned ultraviolet irradiation treatment, while synthesizing quantum dots by utilizing the difference in solubility of the second solvent to the precursor and the first solvent, and reducing the probability of bubble generation inside the microfluidic chip by ultrasonic treatment to improve the quantum dot yield and quality, the present application can also increase the ion kinetic energy of the first precursor and the ion kinetic energy of the second precursor in the precursor solution, thereby accelerating the uniform mixing between the first precursor and the second precursor. In some embodiments, the precursor solution in the microfluidic chip can also be subjected to plasma irradiation treatment to increase the ion kinetic energy, which will not be repeated here.

[0082] Specifically, in step S13, the second solvent is insoluble in the first precursor, the second precursor, the first ligand and the second ligand in the precursor solution, and is miscible with the first solvent in the precursor solution. Further, the second solvent and the precursor solution are mixed to obtain a quantum dot fluid including quantum dots.

[0083] Since the second solvent and the first solvent are mutually soluble, in the quantum dot fluid generated above, the quantum dots generated by the reaction of the first precursor and the second precursor are in the system of the mixed solvent formed after the first solvent and the second solvent are mutually soluble, and a "quantum dot fluid" is formed macroscopically. Among them, the quantum dot fluid exists in the mixing channel of the microfluidic chip in the form of a continuous fluid, that is, the quantum dot fluid is a continuous phase, so that the quantum dot fluid can form quantum dot micro droplets under the shearing action of the carrier phase.

[0084] Therefore, the present application adds a second solvent to the precursor solution. Since the second solvent is a poor solvent for the first precursor and the second precursor in the precursor solution, but is miscible with the first solvent in the precursor solution, the solubility difference of the second solvent to the first precursor, the second precursor and the first solvent is utilized, so that the quantum dots generated by the reaction of the first precursor and the second precursor can precipitate from the first solvent, thereby generating a quantum dot fluid with a mixed solvent of the second solvent and the first solvent as the system solvent.

[0085] In some embodiments, the second solvent may be selected from but not limited to at least one of diethyl ether and cyclohexane. It should be noted that the specific material of the second solvent may be selected according to the selection of the first precursor, the second precursor, the first ligand, the second ligand and the first solvent, as long as the second solvent satisfies the requirement of "insoluble in the first precursor, the second precursor, the first ligand and the second ligand, and miscible with the first solvent", it is within the protection scope of this application.

[0086] In step S13, the flow rate ratio of the first solvent to the second solvent in the microfluidic chip is 1:10-1:50. Within the above flow rate range, the precipitation yield and precipitation rate of quantum dots under the action of the second solvent can be increased to increase the generation rate of the quantum dot fluid, thereby increasing the yield of quantum dots. In some embodiments, the above flow rate ratio can specifically be 1:10, 1:15, 1:20, 1:25, 1:30, 1:35, 1:40, 1:45 or 1:50.

[0087] In some embodiments, after step S13, the method for preparing quantum dots further comprises the steps of:

[0088] S14: vacuuming the quantum dot fluid in the microfluidic chip.

[0089] The inventors of the present application found in experimental research that when the second solvent is mixed with the precursor solution, the large amount of precipitation of quantum dots will cause changes in the air pressure in the microfluidic chip, which will easily generate new bubbles inside the microfluidic chip, especially on the inner wall of the channel. Further, since nano-scale quantum dots such as perovskite quantum dots have a higher surface state, the quantum dots precipitated on the inner wall of the channel of the microfluidic chip are prone to agglomeration and accumulation inside the chip, thereby increasing the probability of blockage inside the microfluidic chip, which will cause the quantum dots to be unable to be removed from the microfluidic chip, significantly reducing the yield of quantum dots. In addition, since quantum dots are more sensitive to the growth environment, the generation of bubbles inside the microfluidic chip will also affect the state of each phase during the synthesis of quantum dots, which will easily lead to an increase in the surface defect state of the synthesized quantum dots, making the quantum dots uneven in morphology. Further, when the above-mentioned quantum dots are applied to light-emitting devices, the luminescence performance of the light-emitting devices will be reduced.

[0090] In view of the above technical problems, the present application can eliminate bubbles generated by the large-scale precipitation of quantum dots in the microfluidic chip by vacuumizing the quantum dot fluid obtained after mixing the second solvent with the precursor solution. On the one hand, the elimination of bubbles can avoid blockage inside the microfluidic chip and ensure the continuous phase state of the quantum dot fluid, so as to improve the morphology of the quantum dot microdroplets after subsequent shearing, so that after the quantum dot microdroplets are broken, the quantum dots can be smoothly taken out from the microfluidic chip, which is conducive to improving the yield of quantum dots. On the other hand, the elimination of bubbles can also avoid the state of each phase in the quantum dot synthesis process from being affected, and can reduce the surface defect state of the quantum dots to improve the uniformity of the quantum dot morphology. Furthermore, when the quantum dots in the present application are applied to light-emitting devices, it is conducive to improving the luminescence performance of the light-emitting devices.

[0091] In some embodiments, in the vacuum treatment step, the vacuum degree can be set to 0.1 mbar-0.3 mbar, for example, 0.1 mbar, 0.15 mbar, 0.2 mbar, 0.25 mbar or 0.3 mbar.

[0092] In some embodiments, a vacuum negative pressure device can be used to evacuate the quantum dot fluid in the microfluidic chip. Since the use of the above device does not require additional heating treatment, the temperature can be prevented from affecting the quantum dots inside the quantum dot fluid, thereby improving the stability of the subsequently generated quantum dot microdroplets, and preventing the quantum dot microdroplets from rupturing inside the microfluidic chip channel due to temperature changes in the system and being unable to be removed, thereby helping to improve the yield of quantum dots.

[0093] In some embodiments, an ultrasonic device may be used to perform ultrasonic treatment on the quantum dot fluid in the microfluidic chip to eliminate bubbles, which will not be described in detail here.

[0094] In some embodiments, after step S14, the method for preparing quantum dots further comprises the steps of:

[0095] S15: injecting a third solvent into the microfluidic chip, the third solvent and the quantum dot fluid are mixed to obtain quantum dot microdroplets, the quantum dot microdroplets flow out of the microfluidic chip to obtain quantum dots, wherein the third solvent is insoluble in the second solvent.

[0096] In the present application, the third solvent is a carrier phase, which is used to shear the quantum dot fluid (continuous phase) to form quantum dot microdroplets. The quantum dot microdroplets are composed of quantum dots and a mixed solvent coated on the quantum dots, and the mixed solvent includes a first solvent and a second solvent. In some embodiments, the third solvent can be selected from but not limited to at least one of dimethyl sulfoxide, acetonitrile and methanol.

[0097] In some embodiments, taking the synthesized quantum dots as perovskite quantum dots as an example, the first solvent, the second solvent and the third solvent can be selected from but not limited to the following combinations: combination one "dimethylformamide, diethyl ether and dimethyl sulfoxide"; combination two "dimethylformamide, cyclohexane and acetonitrile"; combination three "dimethylformamide, cyclohexane and methanol"; combination four "dimethyl sulfoxide, cyclohexane and methanol". The combination of the above combination solvents can improve the synthesis yield and quality of quantum dots.

[0098] In step S15, the flow rate ratio of the second solvent and the third solvent in the microfluidic chip can be set to 1:3-1:10. Within the above flow rate range, the shear rate of the third solvent on the quantum dot fluid can be increased, and the generation rate of quantum dot microdroplets can be increased to further improve the yield and quality of quantum dots. In some embodiments, the above flow rate ratio can be specifically 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9 or 1:10.

[0099] In some embodiments, in step S15, after the third solvent and the quantum dot fluid are mixed to obtain quantum dot microdroplets, the method for preparing quantum dots further includes the step of cooling the quantum dot microdroplets in the microfluidic chip.

[0100] It is understandable that after the quantum dot microdroplets are formed and before the quantum dot microdroplets flow out of the microfluidic chip, due to the addition of the third solvent, the surface temperature of the quantum dot microdroplets is higher than the temperature of the third solvent surrounding the quantum dot microdroplets, resulting in a temperature difference in the system where the quantum dot microdroplets are located. Affected by the above temperature difference, the quantum dot microdroplets are prone to contact the inner wall of the channel during the outflow process in the channel of the microfluidic chip and break, so that they cannot flow out of the channel smoothly, thereby reducing the yield of quantum dots.

[0101] In response to the above technical problems, the present application can reduce the energy on the surface of the quantum dot microdroplets by cooling the quantum dot microdroplets, thereby reducing the temperature difference between the surface of the quantum dot microdroplets and the surrounding area, thereby reducing the risk of rupture of the quantum dot microdroplets during the flow in the microfluidic chip channel, ensuring that the quantum dot microdroplets can stably flow out of the microfluidic chip channel, thereby helping to improve the yield of quantum dots.

[0102] In some embodiments, the temperature of the cooling treatment may be set to 3°C-5°C, for example, 3°C, 4°C or 5°C.

[0103] In the present application, when the quantum dot microdroplets flow out of the microfluidic chip, the mixed solvent on the outer layer of the quantum dot microdroplets will rupture, thereby releasing the quantum dots, thereby completing the preparation of the quantum dots.

[0104] The present application also provides a light-emitting device, which includes an anode, a light-emitting layer and a cathode, wherein the material of the light-emitting layer may include quantum dots synthesized by the aforementioned method for preparing quantum dots.

[0105] Please refer to Figure 2 and Figure 3The present application also provides a microfluidic reaction system 100, which includes a microfluidic chip 10. The microfluidic chip 10 includes a first injection channel 11, a second injection channel 15 and a reaction channel 13. The first injection channel 11 is used to inject a precursor solution, and the precursor solution includes a precursor and a first solvent. The second injection channel 15 is used to inject a second solvent, and the second solvent is miscible with the first solvent and insoluble with the precursor. The discharge end of the second injection channel 15 is connected to the discharge end of the first injection channel 11. The reaction channel 13 is used to mix the second solvent and the precursor solution to obtain quantum dots. The first end of the reaction channel 13 is respectively connected to the discharge end of the first injection channel 11 and the discharge end of the second injection channel 15.

[0106] In the microfluidic reaction system 100 provided in the present application, by setting a second injection channel 15 between the first injection channel 11 and the reaction channel 13, the quality of quantum dots synthesized using the microfluidic reaction system can be improved by utilizing the solubility difference between the precursor and the first solvent in the precursor solution of the second solvent injected into the second injection channel 15.

[0107] The microfluidic reaction system 100 provided in the present application is described in detail below.

[0108] In some embodiments, the first injection channel 11 has a feed port 11A. The first injection channel 11 includes a first sub-injection channel 111 and a second sub-injection channel 112 arranged in parallel for injecting different precursor solutions. The precursor solution includes a first precursor solution and a second precursor solution. The first sub-injection channel 111 is used to inject the first precursor solution. The first precursor solution may include a first precursor, a first ligand, and a first solvent. The second sub-injection channel 112 is used to inject the second precursor solution. The second precursor solution may include a second precursor, a second ligand, and a first solvent. The first precursor solution injected into the first sub-injection channel 111 and the second precursor solution injected into the second sub-injection channel 112 flow into the mixing channel 12 for mixing and forming a precursor solution. Among them, the first end of the mixing channel 12 is connected to the discharge end of the first injection channel 11, that is, the first end of the mixing channel 12 is connected to the discharge end of the first sub-injection channel 111 and the discharge end of the second sub-injection channel 112. The second end of the mixing channel 12 is communicated with the discharge end of the second injection channel 15 and the first end of the reaction channel 13 .

[0109] It should be noted that the selection of materials for the first precursor, the second precursor, the first ligand and the first solvent can refer to the relevant description of the aforementioned method for preparing quantum dots, which will not be repeated here.

[0110] Specifically, one end of the first sub-injection channel 111 is a first feed port 111a, which is connected to the first injection device 30, and the other end of the first sub-injection channel 111, that is, the discharge end of the first sub-injection channel 111, is connected to the first end of the mixing channel 12. One end of the second sub-injection channel 112 is a second feed port 112a, which is connected to the second injection device 40, and the other end of the second sub-injection channel 112, that is, the discharge end of the second sub-injection channel 112, is also connected to the first end of the mixing channel 12. Among them, the discharge end of the first sub-injection channel 111 and the discharge end of the second sub-injection channel 112 are connected to form a confluence port 11B, and the confluence port 11B is connected to the first end of the mixing channel 12, and the second end of the mixing channel 12 is connected to the first end of the reaction channel 13.

[0111] In some embodiments, the first sub-injection channel 111 and the second sub-injection channel 112 may be arranged in the same plane, that is, the central axis of the first sub-injection channel 111 and the second sub-injection channel 112 is located in the same plane. The above plane may be a plane in the horizontal direction or in the vertical direction. It should be noted that, Figure 2 Only the structure when the first sub-injection channel 111 and the second sub-injection channel 112 are located in the same plane in the horizontal direction is illustrated, but it should not be understood as a limitation to the present application.

[0112] In some embodiments, the microfluidic reaction system 100 further includes an ultrasonic device 20. The ultrasonic device 20 is disposed corresponding to the first injection channel 11. Specifically, the ultrasonic device 20 is used to perform ultrasonic treatment on the first precursor solution in the first sub-injection channel 111 and the second precursor solution in the second sub-injection channel 112. Wherein, the ultrasonic device 20 is disposed corresponding to the first sub-injection channel 111 and the second sub-injection channel 112, so that when the first precursor solution is injected into the first sub-injection channel 111 and the second precursor solution is injected into the second sub-injection channel 112, the ultrasonic device 20 can be used to perform ultrasonic treatment on the first precursor solution in the first sub-injection channel 111 and the second precursor solution in the second sub-injection channel 112, respectively, so that the probability of bubble generation in the first precursor solution in the first sub-injection channel 111 and the second precursor solution in the second sub-injection channel 112 can be reduced, thereby increasing the reaction rate of the first precursor and the second precursor in the quantum dot synthesis process, which helps to improve the yield and quality of the quantum dots.

[0113] In some embodiments, the microfluidic reaction system 100 further includes an ultraviolet irradiation device 50, which is disposed corresponding to the mixing channel 12. Specifically, the ultraviolet irradiation device 50 is used to perform ultraviolet irradiation treatment on the precursor solution flowing through the mixing channel 12 to increase the ion kinetic energy of the first precursor and the ion kinetic energy of the second precursor in the precursor solution, thereby accelerating the uniform mixing between the first precursor and the second precursor. It should be noted that the ultraviolet irradiation device 50 can be placed above or below the mixing channel 12, and the present application does not specifically limit the placement position of the ultraviolet irradiation device 50.

[0114] In some embodiments, the microfluidic chip 10 also includes a second injection channel 15. The second injection channel 15 is connected between the mixing channel 12 and the reaction channel 13, and is used to inject a second solvent. The second solvent is used to mix and react with the precursor solution flowing out of the mixing channel 12 in the reaction channel 13, and generate a quantum dot fluid. Specifically, one end of the second injection channel 15 is a third feed port 15a, which is connected to the third injection device 60, and the other end of the second injection channel 15, that is, the discharge end of the second injection channel 15 is connected to the first end of the reaction channel 13. The second end of the reaction channel 13 is connected to the first end of the outflow channel 14. Among them, the second solvent is insoluble in the first precursor, the second precursor, the first ligand and the second ligand in the precursor solution, and is miscible with the first solvent in the precursor solution.

[0115] In some embodiments, the microfluidic chip 10 further includes a third injection channel 16. The third injection channel 16 is used to inject a third solvent. The third solvent is used to shear the quantum dot fluid flowing out of the reaction channel 13 to form quantum dot microdroplets, and the quantum dot microdroplets flow out of the outflow channel 14 to form quantum dots. Specifically, one end of the third injection channel 16 is a fourth feed port 16a, which is connected to the fourth injection device 70, and the other end of the third injection channel 16, that is, the discharge end of the third injection channel 16 is connected to the first end of the outflow channel 14 and the second end of the reaction channel 13. The second end of the outflow channel 14 is a discharge port 14a. The quantum dot microdroplets flow out of the discharge port 14a and break to form quantum dots.

[0116] Please refer to Figure 3In some embodiments, in the length direction X of the microfluidic chip 10, the ratio of the length L1 of the mixing channel 12 to the length of the microfluidic chip 10 is in the range of 1:3-1:5, for example, it can be 1:3, 1:4 or 1:5. Under the above setting, the uniform mixing between the first precursor and the second precursor in the precursor solution in the mixing channel 12 can be accelerated. Specifically, taking the length of the microfluidic chip 10 as 50 cm as an example, the length L1 of the mixing channel 12 can be set to 10 cm-15 cm, for example, it can be 10 cm, 11 cm, 12 cm, 13 cm, 14 cm or 15 cm.

[0117] Please continue to refer to Figure 3 In some embodiments, in the length direction X of the microfluidic chip 10, the ratio of the length L2 of the reaction channel 13 to the length of the microfluidic chip 10 is in the range of 1:10-1:16, for example, it can be 1:10, 1:11, 1:12, 1:13, 1:14, 1:15 or 1:16. Under the above settings, it can be ensured that the quantum dots can be quickly encapsulated in the solvent after generation to form quantum dot microdroplets, thereby reducing the agglomeration and sedimentation of the quantum dots in the reaction channel 13. Specifically, taking the length of the microfluidic chip 10 as 50 cm as an example, the length L2 of the reaction channel 13 can be 3 cm-5 cm, for example, it can be 3 cm, 3.5 cm, 4 cm, 4.5 cm or 5 cm.

[0118] Please continue to refer to Figure 3 In some embodiments, in the length direction X of the microfluidic chip 10, the ratio of the length L3 of the outflow channel 14 to the length of the microfluidic chip 10 is in the range of 1:2-1:3, for example, 1:2 or 1:3. Under the above settings, it is possible to ensure that the quantum dot micro-droplets flow stably and uniformly over a longer length range, and prevent the quantum dot micro-droplets from breaking in the outflow channel 14. Specifically, taking the length of the microfluidic chip 10 as 50 cm as an example, the length L3 of the outflow channel 14 can be 15 cm-20 cm, for example, 15 cm, 16 cm, 17 cm, 18 cm, 19 cm or 20 cm.

[0119] Please continue to refer to Figure 3In some embodiments, the inner diameter D1 of the mixing channel 12, the inner diameter D2 of the reaction channel 13, and the inner diameter D3 of the outflow channel 14 are increased in sequence. Under the above settings, under the premise of ensuring that the quantum dot droplets in the outflow channel 14 can stably flow out of the outflow channel 14 without adhering to the inner wall of the outflow channel 14, by setting the inner diameter D2 of the reaction channel 13 to be smaller than the inner diameter D3 of the outflow channel 14, the precursor in the reaction channel 13 can react inside the channel of relatively small size, which is conducive to improving the reaction rate; further, by setting the inner diameter D1 of the mixing channel 12 to be smaller than the inner diameter D2 of the reaction channel 13, the uniform mixing of the precursor solution in the mixing channel 12 can be accelerated.

[0120] In some embodiments, the inner diameter D1 of the mixing channel 12 may be set to 100 μm-130 μm, for example, 100 μm, 105 μm, 110 μm, 115 μm, 120 μm, 125 μm or 130 μm.

[0121] In some embodiments, the inner diameter D2 of the reaction channel 13 can be set to 170 μm-220 μm, for example, 170 μm, 175 μm, 180 μm, 185 μm, 190 μm, 195 μm, 200 μm, 205 μm, 210 μm, 215 μm or 220 μm.

[0122] In some embodiments, the inner diameter D3 of the outflow channel 14 may be set to 260 μm-300 μm, for example, 260 μm, 265 μm, 270 μm, 275 μm, 280 μm, 285 μm, 290 μm, 295 μm or 300 μm.

[0123] It should be noted that, in some embodiments, the inner diameter D1 of the mixing channel 12, the inner diameter D2 of the reaction channel 13, and the inner diameter D3 of the outflow channel 14 may also be set to be the same to reduce the difficulty of manufacturing the microfluidic chip 10, which will not be repeated here.

[0124] In some embodiments, the microfluidic reaction system 100 also includes a negative pressure device 80. The negative pressure device 80 is arranged corresponding to the reaction channel 13, and is used to vacuum the quantum dot fluid in the reaction channel 13 to eliminate bubbles generated in the reaction channel 13 due to the precipitation of quantum dots. On the one hand, the above-mentioned arrangement can prevent the blockage of quantum dots in the reaction channel 13, so that the quantum dots in the quantum dot fluid can finally be smoothly taken out from the microfluidic chip 10, which is beneficial to improve the yield of quantum dots; on the other hand, the elimination of bubbles can also prevent the state of each phase in the quantum dot synthesis process from being affected, and thus can reduce the surface defect state of quantum dots to improve the uniformity of the quantum dot morphology. Furthermore, when the quantum dots in the present application are applied to light-emitting devices, it is beneficial to improve the luminescence performance of the light-emitting devices.

[0125] In some embodiments, the microfluidic reaction system 100 further includes a cooling device 90. The cooling device 90 is disposed corresponding to the outflow channel 14, and is used to cool the quantum dot microdroplets generated in the outflow channel 14 to reduce the energy on the surface of the quantum dot microdroplets, thereby reducing the temperature difference between the surface of the quantum dot microdroplets and the surroundings, thereby reducing the risk of rupture of the quantum dot microdroplets during the flow process, so that the quantum dot microdroplets can stably flow out of the outflow channel 14, thereby helping to improve the yield of quantum dots.

[0126] It should be noted that the aforementioned method for preparing quantum dots can be prepared using the microfluidic reaction system 100 provided in the present application.

[0127] The above is a detailed introduction to a method for preparing quantum dots and a microfluidic reaction system provided by the present application. Specific examples are used in this article to illustrate the principles and implementation methods of the present application. The description of the above embodiments is only used to help understand the method of the present application and its core idea. At the same time, for technical personnel in this field, according to the idea of ​​the present application, there will be changes in the specific implementation method and application scope. In summary, the content of this specification should not be understood as a limitation on the present application.

Claims

1. A method for preparing quantum dots, characterized in that: The following steps are involved: Providing a precursor solution, wherein the precursor solution comprises a precursor and a first solvent; and A second solvent is provided, and the second solvent is mixed with the precursor solution to obtain quantum dots; wherein the second solvent is miscible with the first solvent, and the second solvent is insoluble with the precursor.

2. The method for preparing quantum dots according to claim 1, characterized in that: In the step of mixing the second solvent and the precursor solution, a quantum dot fluid including the quantum dots is obtained after the second solvent and the precursor solution are mixed; The preparation method further includes: providing a third solvent, and mixing the third solvent with the quantum dot fluid to obtain quantum dot microdroplets containing the quantum dots; wherein the third solvent is insoluble in the second solvent.

3. The method for preparing quantum dots according to claim 2, characterized in that: Before the step of mixing the second solvent and the precursor solution, the preparation method further comprises: injecting the precursor solution into a microfluidic chip; The step of mixing the second solvent with the precursor solution comprises: injecting the second solvent into the microfluidic chip; wherein the flow rate ratio of the first solvent to the second solvent in the microfluidic chip is 1:10-1:50; The step of mixing the third solvent and the quantum dot fluid comprises: injecting the third solvent into the microfluidic chip; wherein the flow rate ratio of the second solvent to the third solvent in the microfluidic chip is 1:3-1:

10.

4. The method for preparing quantum dots according to claim 2, characterized in that: The first solvent comprises dimethylformamide and / or dimethyl sulfoxide; and / or The second solvent comprises diethyl ether and / or cyclohexane; and / or The third solvent includes at least one of dimethyl sulfoxide, acetonitrile and methanol.

5. The method for preparing quantum dots according to claim 2, characterized in that: The first solvent, the second solvent and the third solvent are dimethylformamide, diethyl ether and dimethyl sulfoxide in sequence; or The first solvent, the second solvent and the third solvent are dimethylformamide, cyclohexane and acetonitrile in sequence; or The first solvent, the second solvent and the third solvent are dimethylformamide, cyclohexane and methanol in sequence; or The first solvent, the second solvent and the third solvent are dimethyl sulfoxide, cyclohexane and methanol respectively.

6. The method for preparing quantum dots according to claim 1, characterized in that: Before the step of mixing the second solvent and the precursor solution, the preparation method further comprises: performing ultrasonic treatment on the precursor solution.

7. The method for preparing quantum dots according to claim 1, characterized in that: The precursor includes a first precursor and a second precursor, the first solvent includes a first sub-solvent and a second sub-solvent, the first sub-solvent and the second sub-solvent are both miscible with the second solvent, the first precursor and the second precursor are different, and the first sub-solvent and the second sub-solvent are the same or different; the precursor solution includes a first precursor solution and a second precursor solution, the first precursor solution includes the first precursor and the first sub-solvent, and the second precursor solution includes the second precursor and the second sub-solvent; Before the step of mixing the second solvent and the precursor solution, the preparation method further comprises: respectively subjecting the first precursor solution and the second precursor solution to ultrasonic treatment; The first precursor solution and the second precursor solution after the ultrasonic treatment are mixed to obtain the precursor solution.

8. The method for preparing quantum dots according to claim 7, characterized in that: After the step of mixing the first precursor solution and the second precursor solution after the ultrasonic treatment, the preparation method further comprises: subjecting the mixed precursor solution to ultraviolet irradiation treatment.

9. The method for preparing quantum dots according to claim 2, characterized in that: After obtaining the quantum dot fluid including the quantum dots, the preparation method further comprises: vacuumizing the quantum dot fluid; and / or After obtaining the quantum dot micro-droplets containing the quantum dots, the preparation method further comprises: cooling the quantum dot micro-droplets.

10. The method for preparing quantum dots according to claim 1, characterized in that: Before the step of mixing the second solvent and the precursor solution, the preparation method further comprises: activating the precursor solution.

11. A microfluidic reaction system, characterized in that: A microfluidic chip is included, wherein the microfluidic chip comprises: A first injection channel, used for injecting a precursor solution, wherein the precursor solution includes a precursor and a first solvent; a second injection channel for injecting a second solvent, wherein a discharge end of the second injection channel is connected to a discharge end of the first injection channel; wherein the second solvent is miscible with the first solvent and insoluble with the precursor; and A reaction channel, wherein the first end of the reaction channel is respectively connected to the discharge end of the first injection channel and the discharge end of the second injection channel, so as to mix the second solvent and the precursor solution to obtain quantum dots.

12. The microfluidic reaction system according to claim 11, characterized in that: The microfluidic chip also includes: a third injection channel, for injecting a third solvent, the third solvent being insoluble in the second solvent; wherein a discharge end of the third injection channel is connected to the second end of the reaction channel; and An outflow channel is used to mix the third solvent and the quantum dot fluid including the quantum dots flowing out from the second end of the reaction channel to obtain quantum dot microdroplets; wherein the feed end of the outflow channel is connected to the discharge end of the third injection channel and the second end of the reaction channel.

13. The microfluidic reaction system according to claim 12, characterized in that: The microfluidic chip further comprises a mixing channel, a first end of the mixing channel is connected to the discharge end of the first injection channel, and a second end of the mixing channel is connected to the discharge end of the second injection channel and the first end of the reaction channel; The first injection channel includes a first sub-injection channel and a second sub-injection channel arranged in parallel, the discharge end of the first sub-injection channel and the discharge end of the second sub-injection channel are connected to form a confluence, and the first end of the mixing channel is connected to the confluence.

14. The microfluidic reaction system according to claim 13, characterized in that: In the length direction of the microfluidic chip, the ratio of the length of the mixing channel to the length of the microfluidic chip is in the range of 1:3-1:5; and / or In the length direction of the microfluidic chip, the ratio of the length of the reaction channel to the length of the microfluidic chip is in the range of 1:10-1:16; and / or In the length direction of the microfluidic chip, the ratio of the length of the outflow channel to the length of the microfluidic chip is in the range of 1:2-1:

3.

15. The microfluidic reaction system according to claim 13, characterized in that: The length of the mixing channel is 10cm-15cm; and / or, the length of the reaction channel is 3cm-5cm; and / or, the length of the outflow channel is 15cm-20cm.

16. The microfluidic reaction system according to claim 13, characterized in that: The inner diameter of the mixing channel is 100 μm-130 μm; and / or, the inner diameter of the reaction channel is 170 μm-220 μm; and / or, the inner diameter of the outflow channel is 260 μm-300 μm.

17. The microfluidic reaction system according to claim 13, characterized in that: The microfluidic chip further comprises an ultrasonic device, and the ultrasonic device is arranged corresponding to the first injection channel; and / or The microfluidic reaction system further comprises an ultraviolet irradiation device, and the ultraviolet irradiation device is arranged corresponding to the mixing channel; and / or The microfluidic reaction system further comprises a negative pressure device, and the negative pressure device is arranged corresponding to the reaction channel; and / or The microfluidic reaction system further comprises a cooling device, and the cooling device is arranged corresponding to the outflow channel.

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