An alcohol-free magnetic bead method virus extraction residue detection device

Abstract

The present invention relates to the technical field of residual detection, and discloses a detection device for residual virus extraction by an alcohol-free magnetic bead method, comprising a bottom plate, and also comprising: a turntable, which is rotatably arranged above the bottom plate; a carrier assembly, which has four carrier assemblies, which are evenly distributed in a ring shape on the top of the turntable, and the carrier assembly is used to place the residual extract to be detected; a cleaning and drying assembly, which is used to clean and dry the carrier assembly after use; and a limiting assembly, which is used to limit the carrier assembly. The present invention can automatically clean and dry the slide glass and cover glass after use, and when the slide glass and cover glass are automatically cleaned and dried, they can be fully cleaned and dried from top to bottom, ensuring the effect of the subsequent reuse of the slide glass and cover glass, without the need to manually remove the slide glass and cover glass repeatedly, thereby improving the effect of residual virus extraction detection by the alcohol-free magnetic bead method.

Description

Technical Field

[0001] The invention relates to the technical field of residue detection, and in particular to a virus extraction residue detection device using an alcohol-free magnetic bead method. Background Art

[0002] Alcohol-free magnetic bead virus extraction is a virus separation and purification technology that uses the affinity of specially made magnetic beads to viruses to quickly and efficiently capture virus particles. The key is to use alcohol-free solvents to avoid potential damage to the virus by alcohol and maintain its biological activity and structural integrity. There will be residues after alcohol-free magnetic bead virus extraction, and the residues need to be tested during extraction. Testing the residues can confirm the purity of the extraction process, thereby ensuring the reliability of subsequent experiments.

[0003] The current alcohol-free magnetic bead virus extraction residue detection device usually detects the alcohol-free magnetic bead virus extraction residue through an electron microscope. When multiple groups of residues need to be detected, the staff is required to repeatedly clean or remove the slides and cover slides, which reduces the effect and efficiency of the residue detection. Therefore, it is urgent to design an alcohol-free magnetic bead virus extraction residue detection device. Summary of the invention

[0004] The purpose of the present invention is to solve the problems existing in the prior art and to propose an alcohol-free magnetic bead method virus extraction residue detection device.

[0005] In order to achieve the above object, the present invention adopts the following technical solutions:

[0006] An alcohol-free magnetic bead method virus extraction residue detection device comprises a bottom plate and also comprises:

[0007] A turntable is rotatably arranged above the bottom plate;

[0008] There are four loading components, which are evenly distributed on the top of the turntable in a ring shape. The loading components are used to place the residual extract to be tested;

[0009] A first L-shaped plate, wherein the bottom of the vertical side of the first L-shaped plate is fixedly mounted on the top of the bottom plate, the horizontal side of the first L-shaped plate is located above the turntable, and an electron microscope is mounted on the bottom of the horizontal side of the first L-shaped plate;

[0010] A cleaning and drying component is arranged on the top of the bottom plate and is used to clean and dry the object-carrying component after use;

[0011] The limiting component is arranged above the turntable and is used to limit the loading component.

[0012] As a further technical solution of the present invention, an annular slide is fixedly installed on the top of the base plate, four support columns evenly distributed in a ring shape are vertically fixedly installed on the bottom of the turntable, the ends of the four support columns are slidably set inside the annular slide, a drive motor is vertically installed on the top of the base plate, the output shaft of the drive motor is installed at the center of the bottom of the turntable, and a collection box is also placed on the top of the base plate.

[0013] As a further technical solution of the present invention, the cleaning and drying component includes: a second L-shaped plate and a third L-shaped plate, the vertical sides of the second L-shaped plate and the third L-shaped plate are fixedly installed at corresponding positions on the top of the bottom plate, a box is installed on the top of the second L-shaped plate, an injection pipe and a liquid outlet pipe are connected and installed on the box, and cleaning liquid is provided inside the box, a U-shaped water spray pipe is arranged below the horizontal side of the second L-shaped plate, and a corresponding first hose is connected and installed on the bottom of the box, and the end of the first hose is connected and installed on the U-shaped water spray pipe.

[0014] As a further technical solution of the present invention, a hot air blower is installed on the top of the horizontal edge of the third L-shaped plate, and an air inlet pipe and an air outlet pipe are connected and installed on the hot air blower. The air outlet pipe is U-shaped, and the lower horizontal edge of the air outlet pipe is located below the third L-shaped plate. The end of the air outlet pipe away from the hot air blower is connected and installed with a corresponding second hose, and a U-shaped jet pipe is horizontally arranged below the horizontal edge of the third L-shaped plate, and the other end of the second hose is connected to the U-shaped jet pipe.

[0015] As a further technical solution of the present invention, a vertical pole is rotatably installed on the top of the base plate, a cylinder is vertically fixedly installed on the top of the vertical pole, an oblique groove and a straight groove are opened on the surface of the cylinder, the oblique groove and the straight groove are connected end to end, a second sliding column is horizontally arranged above the base plate, the end of the second sliding column is slidably installed inside the oblique groove and the straight groove, a spring rod is vertically fixedly installed on the bottom of the base plate, the telescopic end and the fixed end of the spring rod are slidably connected by a spline, and the top of the telescopic end of the spring rod is fixedly installed on the bottom surface of the second sliding column.

[0016] As a further technical solution of the present invention, a U-shaped rod is fixedly installed at the end of the second sliding column away from the cylinder, and the two ends of the U-shaped rod are respectively installed on the side of the U-shaped water spray pipe and the side of the U-shaped air jet pipe, and a first belt is horizontally rotatably arranged above the bottom plate, and a large pulley and a small pulley are respectively arranged at the two ends inside the first belt, and the large pulley is fixedly sleeved on the surface of the vertical pole, and a fan blade is rotatably installed inside the lower horizontal edge of the air outlet pipe, and a vertical rod is vertically fixedly installed on the top of the small pulley, and the top of the vertical rod is vertically fixedly installed at the center of the bottom of the fan blade, and the surface of the vertical rod is rotatably installed on the inner wall of the air outlet pipe.

[0017] As a further technical solution of the present invention, the limit assembly includes: a limit plate, a folding groove is opened on the surface of the limit plate, a gear ring is horizontally fixedly installed on the top of the limit plate, the gear ring part has teeth, and a mounting plate is horizontally fixedly installed on the top of the limit plate, and the two ends of the mounting plate are respectively fixedly installed on the horizontal edge of the first L-shaped plate and the horizontal edge of the third L-shaped plate.

[0018] As a further technical solution of the present invention, the loading assembly includes: a glass slide, the glass slide is arranged above the turntable, a cover glass is arranged above the glass slide, a slope is opened on the top of the turntable, an L-shaped frame is vertically fixedly installed on the top of the slope, the L-shaped frame is rotatably installed at the center of the side of the glass slide, and two first friction rings abutting each other are arranged on the side of the glass slide, one of the first friction rings is fixedly sleeved on the horizontal edge of the L-shaped frame, and the other first friction ring is fixedly installed on the side of the glass slide.

[0019] As a further technical solution of the present invention, a vertical plate is vertically fixedly installed on the top of the base plate, a rotating rod is rotatably installed on the side of the vertical plate, a second pulley is fixedly installed at the end of the rotating rod away from the vertical plate and the center of the corresponding side of the slide, and a second belt is sleeved on the surfaces of the two second pulleys. Two mutually meshing first bevel gears are arranged above the base plate, one of the first bevel gears is fixedly sleeved on the surface of the rotating rod, and a first telescopic rod is vertically fixedly installed on the top of the other first bevel gear, the fixed end and the telescopic end of the first telescopic rod are slidably connected by a spline, and the first telescopic rod is rotatably installed on the side of the vertical plate through a limit plate.

[0020] As a further technical scheme of the present invention, a rotating column is fixedly installed at the center of the side corresponding to the cover glass, and a first sliding column is rotatably installed at the end of the rotating column away from the cover glass, and the end of the first sliding column away from the rotating column is rotatably installed in the folding groove. Two second friction rings abutting each other are provided on the side of the cover glass, one of the second friction rings is fixedly sleeved on the surface of the rotating column, and the other second friction ring is fixedly installed on the side of the cover glass. A first gear meshing with the gear ring is also fixedly sleeved on the surface of the rotating column. Two second bevel gears meshing with each other are also provided on the side of the cover glass, one of the second bevel gears is fixedly sleeved on the surface of the rotating column, and the other second bevel gear is fixedly installed on the top of the first telescopic rod, and a second telescopic rod is vertically fixedly installed on the top of the bottom plate, the fixed end and the telescopic end of the second telescopic rod are connected by a spline, the telescopic end of the second telescopic rod is fixedly installed on the bottom of the first sliding column, and a sleeve plate is fixedly sleeved on the surface of the telescopic end of the second telescopic rod, and the sleeve plate is sleeved on the telescopic end surface of the first telescopic rod through a bearing.

[0021] The beneficial effects of the present invention are:

[0022] Firstly, the present invention can automatically clean and dry the used slides and cover slips by setting the limiting components and the cleaning and drying components, and when the slides and cover slips are automatically cleaned and dried, they can be cleaned and dried comprehensively from top to bottom, thereby ensuring the effect of subsequent reuse of the slides and cover slips, without the need to manually remove the slides and cover slips repeatedly, thereby improving the effect of residual detection of virus extraction by alcohol-free magnetic beads method;

[0023] Secondly, the present invention, through the arrangement of the object-carrying component and the limiting component, can not only continuously detect the residues of virus extraction by the alcohol-free magnetic bead method, but also can automatically cover the cover glass, and can also automatically separate the cover glass and the slide glass and make them vertical after the detection is completed, so as to facilitate the subsequent cleaning and drying of the cover glass and the slide glass, thereby improving the use effect of the equipment. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 This is a schematic diagram of the structure of a virus extraction residue detection device using an alcohol-free magnetic bead method proposed by the present invention;

[0025] Figure 2 for Figure 1 A magnified schematic diagram of part A;

[0026] Figure 3 This is a schematic diagram of the rear view structure of a virus extraction residue detection device using an alcohol-free magnetic bead method proposed by the present invention;

[0027] Figure 4 This is a schematic diagram of the structure of a virus extraction residue detection device using an alcohol-free magnetic bead method proposed by the present invention, when viewed from above, with the bottom plate removed;

[0028] Figure 5 This is a schematic diagram of the connection structure of a glass slide and a cover glass of a device for detecting virus extraction residues by an alcohol-free magnetic bead method proposed by the present invention;

[0029] Figure 6 for Figure 5 A magnified schematic diagram of part B;

[0030] Figure 7 This is a schematic diagram of the cleaning and drying structure of a glass slide and a cover glass of a device for detecting virus extraction residues by an alcohol-free magnetic bead method proposed by the present invention;

[0031] Figure 8 for Figure 7 Enlarged schematic diagram of part C.

[0032] In the figure: 1, bottom plate; 2, turntable; 3, limit plate; 4, gear ring; 5, mounting plate; 6, first L-shaped plate; 7, second L-shaped plate; 8, third L-shaped plate; 9, box; 10, hot air blower; 11, cylinder; 12, slide glass; 13, cover glass; 14, L-shaped frame; 15, first friction ring; 16, ramp; 17, collection box; 18, air outlet pipe; 19, drive motor; 20, annular slide; 21, support column; 22, second hose; 23, first belt; 24 , the second belt; 25, the second pulley; 26, the rotating rod; 27, the first bevel gear; 28, the first telescopic rod; 29, the second telescopic rod; 30, the sleeve; 31, the first slide column; 32, the rotating column; 33, the second bevel gear; 34, the first gear; 35, the second friction ring; 36, the folding groove; 37, the U-shaped water spray pipe; 38, the U-shaped jet pipe; 39, the U-shaped rod; 40, the second slide column; 41, the inclined groove; 42, the straight groove; 43, the fan blade; 44, the vertical rod; 45, the spring rod. DETAILED DESCRIPTION

[0033] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further explained below in conjunction with specific implementation methods.

[0034] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0035] Please refer to the attached Figure 1 -Attached Figure 8 , a non-alcohol magnetic bead method virus extraction residue detection device, comprising a bottom plate 1, and also comprising: a turntable 2, a loading assembly, a first L-shaped plate 6, a cleaning and drying assembly and a limiting assembly, the turntable 2 is rotatably arranged above the bottom plate 1, there are four loading assemblies, and the four loading assemblies are evenly distributed on the top of the turntable 2 in a ring shape, and the loading assembly is used to place the residual extract to be detected, the bottom of the vertical side of the first L-shaped plate 6 is fixedly installed on the top of the bottom plate 1, the horizontal side of the first L-shaped plate 6 is located above the turntable 2, and an electron microscope is installed at the bottom of the horizontal side of the first L-shaped plate 6, the cleaning and drying assembly is arranged on the top of the bottom plate 1, and the cleaning and drying assembly is used to clean and dry the loading assembly after use, and the limiting assembly is arranged above the turntable 2, and the limiting assembly is used to limit the loading assembly;

[0036] The above method can detect the residue of virus extraction by alcohol-free magnetic beads method, and can clean and dry the used slide glass 12 and cover glass 13, so as to facilitate repeated and quick multiple uses.

[0037] Please refer to the attached Figure 1 -Attached Figure 4 In a preferred embodiment, an annular slide 20 is fixedly installed on the top of the bottom plate 1, four support columns 21 evenly distributed in an annular shape are vertically fixedly installed on the bottom of the turntable 2, and the ends of the four support columns 21 are slidably arranged inside the annular slide 20. A driving motor 19 is vertically installed on the top of the bottom plate 1, and the output shaft of the driving motor 19 is installed at the bottom center of the turntable 2. A collecting box 17 is also placed on the top of the bottom plate 1;

[0038] Specifically, it is generally used to drive the turntable 2, and has realized the continuous detection of the alcohol-free magnetic bead method virus extraction residue, and the detection is convenient and fast.

[0039] Please refer to the attached Figure 1 -Attached Figure 8 In a preferred embodiment, the cleaning and drying assembly includes: a second L-shaped plate 7 and a third L-shaped plate 8, the vertical sides of the second L-shaped plate 7 and the third L-shaped plate 8 are fixedly installed at the corresponding positions on the top of the bottom plate 1, a box body 9 is installed on the top of the second L-shaped plate 7, a liquid injection pipe and a liquid outlet pipe are connected and installed on the box body 9, and a cleaning liquid is provided inside the box body 9, a U-shaped water spray pipe 37 is arranged below the horizontal side of the second L-shaped plate 7, and a matching first hose is connected and installed at the bottom of the box body 9, and the end of the first hose is connected and installed on the U-shaped water spray pipe 37 A hot air blower 10 is installed on the top of the horizontal side of the third L-shaped plate 8, and an air inlet pipe and an air outlet pipe 18 are connected and installed on the hot air blower 10. The air outlet pipe 18 is U-shaped, and the lower horizontal side of the air outlet pipe 18 is located below the third L-shaped plate 8. The end of the air outlet pipe 18 away from the hot air blower 10 is connected and installed with a matching second hose 22. A U-shaped jet pipe 38 is horizontally arranged below the horizontal side of the third L-shaped plate 8, and the other end of the second hose 22 is connected to the U-shaped jet pipe 38. A vertical pole is rotatably installed on the top of the bottom plate 1, and a vertical pole is fixedly installed on the top of the vertical pole. The cylinder 11 has an inclined groove 41 and a straight groove 42 on its surface, and the inclined groove 41 and the straight groove 42 are connected end to end. A second slide column 40 is horizontally arranged above the bottom plate 1, and the end of the second slide column 40 is slidably installed inside the inclined groove 41 and the straight groove 42. A spring rod 45 is vertically fixedly installed at the bottom of the bottom plate 1, and the telescopic end and the fixed end of the spring rod 45 are slidably connected through a spline. The top of the telescopic end of the spring rod 45 is fixedly installed on the bottom surface of the second slide column 40, and a U-shaped rod 3 is fixedly installed at the end of the second slide column 40 away from the cylinder 11 9, the two ends of the U-shaped rod 39 are respectively installed on the side of the U-shaped water spray pipe 37 and the side of the U-shaped air jet pipe 38, the first belt 23 is horizontally rotatably arranged above the bottom plate 1, the two ends of the first belt 23 are respectively provided with a large pulley and a small pulley, the large pulley is fixedly sleeved on the surface of the vertical rod, the fan blade 43 is rotatably installed inside the lower horizontal side of the air outlet pipe 18, the vertical rod 44 is vertically fixedly installed on the top of the small pulley, the top of the vertical rod 44 is vertically fixedly installed at the center of the bottom of the fan blade 43, and the surface of the vertical rod 44 is rotatably installed inside the inner wall of the air outlet pipe 18;

[0040] Furthermore, the used slide glass 12 and cover glass 13 can be automatically cleaned and dried, and when the slide glass 12 and cover glass 13 are automatically cleaned and dried, they can be completely cleaned and dried from top to bottom, ensuring that the slide glass 12 and cover glass 13 can be reused later.

[0041] Please refer to the attached Figure 2 -Attached Figure 8 In a preferred embodiment, the limiting assembly includes: a limiting plate 3, a folding groove 36 is opened on the surface of the limiting plate 3, a toothed ring 4 is horizontally fixedly installed on the top of the limiting plate 3, and the toothed ring 4 has teeth, and a mounting plate 5 is horizontally fixedly installed on the top of the limiting plate 3, and both ends of the mounting plate 5 are respectively fixedly installed on the horizontal side of the first L-shaped plate 6 and the horizontal side of the third L-shaped plate 8;

[0042] Specifically, it is used to limit the cover glass 13, ensuring that when residual substances need to be detected, it can cooperate with the slide glass 12 to improve the detection result.

[0043] Please refer to the attached Figure 1 -Attached Figure 8In a preferred embodiment, the loading assembly includes: a glass slide 12, the glass slide 12 is arranged above the turntable 2, a cover glass 13 is arranged above the glass slide 12, a slope 16 is provided on the top of the turntable 2, an L-shaped frame 14 is vertically fixedly installed on the top of the slope 16, the L-shaped frame 14 is horizontally rotatably installed at the center of the side of the glass slide 12, two first friction rings 15 abutting against each other are arranged on the side of the glass slide 12, one of the first friction rings 15 is fixedly sleeved on the horizontal side of the L-shaped frame 14, and the other first friction ring 15 is fixedly installed on the side of the glass slide 12, and the bottom plate 1 A vertical plate is also fixedly installed on the top, and a rotating rod 26 is rotatably installed on the side of the vertical plate. A second pulley 25 is fixedly installed at the end of the rotating rod 26 away from the vertical plate and the center of the corresponding side of the slide 12. The surfaces of the two second pulleys 25 are sleeved with second belts 24. Two mutually meshing first bevel gears 27 are arranged above the bottom plate 1, one of which is fixedly sleeved on the surface of the rotating rod 26, and a first telescopic rod 28 is vertically fixedly installed on the top of the other first bevel gear 27. The fixed end and the telescopic end of the first telescopic rod 28 are slidably connected by a spline. 8 is rotatably mounted on the side of the vertical plate through a limit plate, a rotating column 32 is fixedly mounted at the center of the corresponding side of the cover glass 13, a first sliding column 31 is rotatably mounted on the end of the rotating column 32 away from the cover glass 13, and the end of the first sliding column 31 away from the rotating column 32 is rotatably mounted inside the folding groove 36, and two second friction rings 35 abutting each other are provided on the side of the cover glass 13, one of the second friction rings 35 is fixedly sleeved on the surface of the rotating column 32, and the other second friction ring 35 is fixedly mounted on the side of the cover glass 13, and a first gear 30 meshing with the gear ring 4 is also fixedly sleeved on the surface of the rotating column 32. 4. Two second bevel gears 33 meshing with each other are also provided on the side of the cover glass 13, one of the second bevel gears 33 is fixedly sleeved on the surface of the rotating column 32, and the other second bevel gear 33 is fixedly installed on the top of the first telescopic rod 28. A second telescopic rod 29 is vertically fixedly installed on the top of the bottom plate 1, and the fixed end and the telescopic end of the second telescopic rod 29 are connected by splines. The telescopic end of the second telescopic rod 29 is fixedly installed on the bottom of the first sliding column 31, and a sleeve plate 30 is fixedly sleeved on the surface of the telescopic end of the second telescopic rod 29, and the sleeve plate 30 is sleeved on the surface of the telescopic end of the first telescopic rod 28 through a bearing;

[0044] Preferably, not only can the alcohol-free magnetic bead method virus extraction residues be continuously detected, but also the cover glass 13 can be automatically covered, and after the detection is completed, the cover glass 13 and the slide glass 12 can be automatically separated and vertically erected, so as to facilitate the subsequent cleaning and drying of the cover glass 13 and the slide glass 12.

[0045] The working principle of the present invention is as follows: First, the staff puts the residual substance of the virus extraction by the alcohol-free magnetic bead method on the corresponding slide 12, and then starts the drive motor 19 to drive the turntable 2 to rotate. It should be noted that the drive motor 19 rotates 90 degrees each time;

[0046] When the driving motor 19 rotates for the first time, the turntable 2 rotates and drives the components installed thereon to rotate with the center of the turntable 2 as the center of the circle, then the corresponding first slide 31 will move downward along the folding groove 36 as the path, so that the cover glass 13 moves downward to cover the extracted substance. When the driving motor 19 stops rotating this time, the corresponding slide glass 12 and cover glass 13 are located under the electron microscope. At this time, the extracted residual substance can be detected by the electron microscope. When the detection of the extracted residual substance is completed;

[0047] When the driving motor 19 rotates for the second time, the corresponding cover glass 13 will move upward along the folding groove 36. When the first sliding column 31 moves to the highest position of the folding groove 36 and continues to move, the first gear 34 on the corresponding rotating column 32 contacts the convex teeth on the gear ring 4. Due to the number of convex teeth on the gear ring 4, the first gear 34 will only rotate ninety degrees at this time. The rotation of the first gear 34 drives the rotating column 32 to rotate. The rotation of the rotating column 32 drives the cover glass 13 and the second bevel gear 33 to rotate. The rotation of the second bevel gear 33 drives the first telescopic rod 28 to rotate. The rotation of the first telescopic rod 28 drives the first bevel gear 27 to rotate. The rotation of the wheel 27 drives the rotating rod 26 to rotate, and the rotation of the rotating rod 26 drives the second belt 24 and the second pulley 25 to rotate, and the rotation of the second pulley 25 drives the slide glass 12 to rotate. When the driving motor 19 stops rotating for the second time, the used slide glass 12 and cover glass 13 can be made vertical, and the slide glass 12 and cover glass 13 will rotate vertically to the bottom of the second L-shaped plate 7. It should be noted that a liquid pump connected to the first hose is installed inside the box body 9. The liquid pump and the hot air blower 10 work at the same time. The liquid pump can pump the cleaning liquid inside the box body 9 through the first hose to the U-shaped water spray pipe 37 to spray it to the slide glass 12 and the cover glass 13. When the hot air blower 10 is working, the hot air will be ejected from the U-shaped jet pipe 38 through the air outlet pipe 18 and the second hose 22 to dry the cleaned slide glass 12 and cover glass 13, and the hot air will drive the fan blade 43 to rotate when passing through the air outlet pipe 18, the rotation of the fan blade 43 drives the vertical rod 44 to rotate, the rotation of the vertical rod 44 drives the small pulley to rotate, the rotation of the small pulley drives the first belt 23 to rotate, the rotation of the first belt 23 drives the large pulley to rotate slowly, the rotation of the large pulley drives the vertical rod to rotate, the rotation of the vertical rod drives the cylinder 11 to rotate, the rotation of the cylinder 11 drives the inclined slot 41 and the straight slot 42 to rotate, and further the second slide column 40 can be moved The second slide column 40 moves downward and causes the spring rod 45 to generate elastic force, and the second slide column 40 moves downward to drive the U-shaped rod 39, the U-shaped air jet pipe 38 and the U-shaped water spray pipe 37 to move downward. The U-shaped air jet pipe 38 and the U-shaped water spray pipe 37 move downward to fully clean and dry the slide glass 12 and the cover glass 13, thereby ensuring the effect of reuse. When the second slide column 40 moves to the connection between the end of the inclined groove 41 and the end of the straight groove 42, the elastic force generated by the spring rod 45 causes the second slide column 40, the U-shaped rod 39, the U-shaped air jet pipe 38 and the U-shaped water spray pipe 37 to move upward quickly, thereby completing the cleaning and drying of the slide glass 12 and the cover glass 13.

[0048] The driving motor 19 rotates for the third time, and the vertical slide glass 12 and cover glass 13 rotate vertically to below the third L-shaped plate 8. As can be seen from the above, the cleaned slide glass 12 and cover glass 13 are dried at this time;

[0049] The driving motor 19 rotates for the fourth time, so that the corresponding first gear 34 and the gear ring 4 are meshed. It should be noted that, due to the number of convex teeth on the gear ring 4, the first gear 34 rotates 270 degrees at this time. In summary, it can be known that the slide glass 12 and the cover glass 13 after cleaning and drying can be reset;

[0050] In summary, the alcohol-free magnetic bead virus extraction residues can be detected by repeating the process repeatedly, and the detection is convenient and fast, thereby improving the use effect of the equipment.

[0051] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A virus extraction residue detection device using an alcohol-free magnetic bead method, comprising a bottom plate (1), characterized in that: Also includes: A turntable (2), the turntable (2) being rotatably disposed above the bottom plate (1); A carrier assembly, wherein there are four of the carrier assemblies, and the four carrier assemblies are evenly distributed in a ring shape on the top of the turntable (2), and the carrier assemblies are used to place the residual extract to be detected; a first L-shaped plate (6), wherein the bottom of the vertical side of the first L-shaped plate (6) is fixedly mounted on the top of the base plate (1), the horizontal side of the first L-shaped plate (6) is located above the turntable (2), and an electron microscope is mounted on the bottom of the horizontal side of the first L-shaped plate (6); A cleaning and drying component, the cleaning and drying component is arranged on the top of the bottom plate (1), and is used to clean and dry the object-carrying component after use; A limiting assembly, the limiting assembly being arranged above the turntable (2), and being used to limit the position of the object-carrying assembly; An annular slideway (20) is fixedly mounted on the top of the base plate (1); four support columns (21) evenly distributed in an annular shape are vertically fixedly mounted on the bottom of the turntable (2); the ends of the four support columns (21) are slidably arranged inside the annular slideway (20); a drive motor (19) is vertically mounted on the top of the base plate (1); the output shaft of the drive motor (19) is mounted at the center of the bottom of the turntable (2); and a collection box (17) is also placed on the top of the base plate (1); The cleaning and drying assembly comprises: a second L-shaped plate (7) and a third L-shaped plate (8), the vertical sides of the second L-shaped plate (7) and the third L-shaped plate (8) are fixedly mounted at corresponding positions on the top of the bottom plate (1), a box body (9) is mounted on the top of the second L-shaped plate (7), a liquid injection pipe and a liquid outlet pipe are connected and mounted on the box body (9), and a cleaning liquid is provided inside the box body (9), a U-shaped water spray pipe (37) is arranged below the horizontal side of the second L-shaped plate (7), and a first hose that matches the bottom of the box body (9) is connected and mounted, and the end of the first hose is connected and mounted on the U-shaped water spray pipe (37); A hot air blower (10) is installed at the top of the horizontal edge of the third L-shaped plate (8); an air inlet pipe and an air outlet pipe (18) are installed on the hot air blower (10); the air outlet pipe (18) is U-shaped, and the lower horizontal edge of the air outlet pipe (18) is located below the third L-shaped plate (8); an end of the air outlet pipe (18) away from the hot air blower (10) is installed in communication with a matching second hose (22); a U-shaped jet pipe (38) is horizontally arranged below the horizontal edge of the third L-shaped plate (8); the other end of the second hose (22) is connected to the U-shaped jet pipe (38); A vertical pole is rotatably mounted on the top of the base plate (1), a cylinder (11) is vertically fixedly mounted on the top of the vertical pole, an inclined groove (41) and a straight groove (42) are provided on the surface of the cylinder (11), the inclined groove (41) and the straight groove (42) are connected end to end, a second sliding column (40) is horizontally arranged above the base plate (1), the end of the second sliding column (40) is slidably mounted inside the inclined groove (41) and the straight groove (42), a spring rod (45) is vertically fixedly mounted on the bottom of the base plate (1), the telescopic end and the fixed end of the spring rod (45) are slidably connected via a spline, the top of the telescopic end of the spring rod (45) is fixedly mounted on the bottom surface of the second sliding column (40), and the second sliding column (40) is far A U-shaped rod (39) is fixedly installed at the end of the cylinder (11), and the two ends of the U-shaped rod (39) are respectively installed on the side of the U-shaped water spray pipe (37) and the side of the U-shaped air jet pipe (38). A first belt (23) is horizontally rotatably arranged above the bottom plate (1), and a large pulley and a small pulley are respectively arranged at the two ends inside the first belt (23), and the large pulley is fixedly sleeved on the surface of the vertical rod. A fan blade (43) is rotatably installed inside the lower horizontal edge of the air outlet pipe (18), and a vertical rod (44) is vertically fixedly installed on the top of the small pulley. The top end of the vertical rod (44) is vertically fixedly installed at the center of the bottom of the fan blade (43), and the surface of the vertical rod (44) is rotatably installed inside the inner wall of the air outlet pipe (18).

2. The alcohol-free magnetic bead method virus extraction residue detection device according to claim 1, characterized in that: The limiting assembly comprises: a limiting plate (3), a folding groove (36) is provided on the surface of the limiting plate (3), a toothed ring (4) is fixedly mounted horizontally on the top of the limiting plate (3), the toothed ring (4) has teeth, a mounting plate (5) is fixedly mounted horizontally on the top of the limiting plate (3), and two ends of the mounting plate (5) are respectively fixedly mounted on the horizontal edge of the first L-shaped plate (6) and the horizontal edge of the third L-shaped plate (8).

3. The alcohol-free magnetic bead method virus extraction residue detection device according to claim 2, characterized in that: The object loading assembly comprises: a glass slide (12), the glass slide (12) being arranged above the turntable (2), a cover glass (13) being arranged above the glass slide (12), a slope (16) being provided on the top of the turntable (2), an L-shaped frame (14) being vertically fixedly mounted on the top of the slope (16), the L-shaped frame (14) being rotatably mounted on the side center of the glass slide (12) in a horizontal direction, two first friction rings (15) abutting against each other being arranged on the side of the glass slide (12), one of the first friction rings (15) being fixedly sleeved on the horizontal side of the L-shaped frame (14), and the other first friction ring (15) being fixedly mounted on the side of the glass slide (12).

4. The alcohol-free magnetic bead method virus extraction residue detection device according to claim 3, characterized in that: A vertical plate is also fixedly mounted on the top of the bottom plate (1), a rotating rod (26) is rotatably mounted on the side of the vertical plate, a second pulley (25) is fixedly mounted on the end of the rotating rod (26) away from the vertical plate and the center of the side corresponding to the slide (12), and a second belt (24) is sleeved on the surface of the two second belt pulleys (25), and two mutually meshing first bevel gears (27) are arranged above the bottom plate (1), one of the first bevel gears (27) is fixedly sleeved on the surface of the rotating rod (26), and a first telescopic rod (28) is vertically fixedly mounted on the top of the other first bevel gear (27), the fixed end and the telescopic end of the first telescopic rod (28) are slidably connected by a spline, and the first telescopic rod (28) is rotatably mounted on the side of the vertical plate through a limit plate.

5. The alcohol-free magnetic bead method virus extraction residue detection device according to claim 4, characterized in that: A rotating column (32) is fixedly mounted at the center of the corresponding side of the cover glass (13); a first sliding column (31) is rotatably mounted at the end of the rotating column (32) away from the cover glass (13); the end of the first sliding column (31) away from the rotating column (32) is rotatably mounted inside the folding groove (36); two second friction rings (35) abutting against each other are provided on the side of the cover glass (13); one of the second friction rings (35) is fixedly sleeved on the surface of the rotating column (32); and the other second friction ring (35) is fixedly mounted on the side of the cover glass (13); a first gear (34) that meshes with the gear ring (4) is also fixedly sleeved on the surface of the rotating column (32); and the cover glass The side surface of the second bevel gear (33) is also provided with two second bevel gears (33) meshing with each other, wherein one of the second bevel gears (33) is fixedly sleeved on the surface of the rotating column (32), and the other second bevel gear (33) is fixedly installed on the top of the first telescopic rod (28). A second telescopic rod (29) is vertically fixedly installed on the top of the bottom plate (1), and the fixed end and the telescopic end of the second telescopic rod (29) are connected by a spline. The telescopic end of the second telescopic rod (29) is fixedly installed on the bottom of the first sliding column (31), and a sleeve plate (30) is fixedly sleeved on the surface of the telescopic end of the second telescopic rod (29), and the sleeve plate (30) is sleeved on the surface of the telescopic end of the first telescopic rod (28) through a bearing.

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