Organic pretreatment equipment for liquid chromatography

Abstract

The invention discloses organic pretreatment equipment for liquid chromatography, and belongs to the technical field of liquid chromatography pretreatment. Comprising a treatment table, a transparent cover is fixed to the top of the treatment table, and a plurality of built-in gloves are installed on one side of the transparent cover; a plurality of operating arms are mounted at the top of the treatment table, a transfer device is mounted at the output end of one operating arm, the bottom of the transfer device communicates with a plurality of transfer pipes with liquid suction needles at the bottoms, liquid suction pistons are slidably arranged in the transfer pipes, the middles of the liquid suction pistons are through, and exhaust pistons are slidably arranged in the liquid suction pistons. By means of the structure, when organic pretreatment is carried out, the operation arm is controlled, solvent mixing is carried out, and needed substances in a sample are extracted; wherein the prepared sample can be automatically extracted, transferred and filtered by controlling the other operation arm provided with the transfer device. Meanwhile, the hands are inserted into the built-in gloves, and then the hands can stretch into the closed transparent cover body to carry out some work which cannot be replaced by machines.

Description

Technical Field

[0001] The invention relates to organic pre-treatment equipment for liquid chromatography, belonging to the technical field of liquid chromatography pre-treatment. Background Art

[0002] Liquid chromatograph is a commonly used chromatographic analysis instrument used to separate, detect and quantitatively analyze the components in a mixture of chemical substances. In a liquid chromatograph, the sample solution is injected into the chromatographic column. Through the interaction between the stationary phase filled in the chromatographic column and the mobile phase (solvent), different components are separated in the chromatographic column at different speeds. Finally, the concentration of each component is detected by the detector to achieve the analysis of the components in the mixture.

[0003] Liquid chromatography-mass spectrometry, referred to as LC-MS, is an instrument that combines liquid chromatography with mass spectrometry. Liquid chromatography (LC) can effectively separate the organic components in the organic sample to be tested, while mass spectrometry (MS) can analyze the separated organic matter one by one to obtain information on the molecular weight, structure and concentration of the organic matter. LC-MS is an indispensable analytical tool for organic analysis laboratories, drug and food inspection laboratories, production process control, quality inspection and other departments.

[0004] When the existing technology uses liquid chromatography or liquid chromatography-mass spectrometry to test samples, especially organic samples, it is generally necessary to pre-treat the samples so that the treated samples can effectively measure the required data after being loaded on the machine; there are various means and methods for pre-treatment, which are appropriately selected according to the sample form. Some samples require special solvent extraction, and some of the extractant solvents used are toxic or volatile, which are harmful to the respiratory system and nervous system of the human body and endanger the health of the operator; After the substance to be tested is extracted, it needs to be filtered. The current common filtering method is to manually press the syringe and filter head to filter the substance to be tested into the sample bottle. However, some samples will be left over during filtration, making the sample capacity inaccurate, and the large amount of residue in the filter also increases the processing burden. Therefore, the operator often needs to draw a tube of air and inject it into the bottle through the filter again, and then blow off the residual sample to speed up the filtration and dripping of the residual sample. Such repeated operations increase the operating burden of the experimenter and also increase the probability of operating errors.

[0005] Based on this, the present invention designs an organic pretreatment device for liquid chromatography to solve the above problems. Summary of the invention

[0006] The technical problem to be solved by the present invention is that some of the extractant solvents used in the prior art are toxic or volatile, which endangers the health of operators; part of the sample will be left over during filtration, resulting in inaccurate sample capacity, increasing the operating burden of the experimenter and also increasing the probability of operating errors.

[0007] The technical problem to be solved by the present invention is achieved by adopting the following technical scheme: an organic pretreatment device for liquid chromatography, comprising a processing table, a transparent cover body is fixed on the top of the processing table, and a plurality of built-in gloves are installed on one side of the transparent cover body; a plurality of operating arms are installed on the top of the processing table, a transfer device is installed on the output end of one of the operating arms, a plurality of transfer tubes with aspiration needles at the bottom are connected to the bottom of the transfer device, aspiration piston is slidably arranged inside the transfer tube, and an exhaust piston is slidably arranged in the middle of the aspiration piston; the transfer device comprises a mounting block, a plurality of mounting cavities are opened inside the mounting block corresponding to the positions of the plurality of transfer tubes, a driving mechanism 1 for driving the aspiration piston and the exhaust piston to slide is arranged in the mounting cavity, and a driving mechanism 2 for driving the exhaust piston to slide is arranged in the transfer tube.

[0008] By adopting the above technical scheme, when performing organic pretreatment, the solvent, beaker and bottle to be used are placed at the designated position of the processing table, and then the operating arm is controlled to mix the solvent and extract the required substances in the sample; wherein, by controlling another operating arm equipped with a transfer device, the prepared sample can be automatically extracted, transferred and filtered. At the same time, by inserting both hands into the built-in gloves, the hands can be inserted into the closed transparent cover to perform some work that cannot be replaced by machines. Through the structure of this application, when performing organic pretreatment, through the cooperation of manual and operating arms, no sample will be left when filtering the sample, so that the sample retention capacity is accurate, the operating burden of the experimenter is reduced, and the probability of operating errors is also reduced. The transparent cover isolates the toxic extractant and the person, so that when the toxic extraction solvent evaporates, it will not cause damage to the human respiratory system and nervous system, and will not endanger the health of the operator, which is very convenient and efficient.

[0009] Specifically, the transferor can be flexibly moved by controlling the operating arm to place the sample and the transfer tube at the designated position, and at the same time, the driving mechanism 1 is used to drive the liquid suction piston to move up and suck the sample to be processed, and the sample after being sucked is pushed down by the driving structure, and the sucked sample is injected into the new sample bottle through the filter. After the injection is completed, the driving mechanism 2 is used to drive the exhaust piston to slide in the transfer tube, and the air in the transfer tube is pumped into the filter to blow out the residual sample in the filter, which greatly reduces the sample carryover. At the same time, when blowing, there is no need to detach from the sample bottle and then blow it out again after inhaling. After the transfer and injection are completed, the residue can be blown out immediately, reducing the intermediate steps, eliminating the need for re-alignment, and improving efficiency. At the same time, it is prevented that the sample that is inhaled again after the transfer is completed drips onto the table, which is beneficial to the cleanliness of the processing table and avoids the large-scale emission of harmful substances.

[0010] The present invention is further configured as follows: three rings are rotatably arranged on the outer wall of the outer push cylinder, a driving rod for driving the three rings to rotate is fixed at the bottom of the moving disk, the bottom of the driving rod is meshed with the inner circle of the outer circle of the three rings, a plurality of outer rotating rods are rotatably connected to the cylinder wall of the outer push cylinder, the tops of the plurality of outer rotating rods are meshed with the inner circle of the middle circle of the three rings, a docking cam is fixed on the outer rotating rod at the bottom of the cylinder wall of the outer push cylinder, a plurality of inner rotating rods are rotatably arranged in the cylinder wall of the inner connecting cylinder, the tops of the plurality of inner rotating rods are meshed with the inner circle of the inner circle of the three rings, a docking cam is also fixed on the inner rotating rod at the bottom of the cylinder wall of the inner connecting cylinder, a plurality of cylinder wall rotating rods are rotatably arranged inside the mounting block, the tops of the plurality of cylinder wall rotating rods are meshed with the outer circle of the outer circle of the three rings, and a docking cam is also fixed on the cylinder wall rotating rod at the bottom of the mounting block. In this embodiment, a motor 1 (not marked in the figure) is connected to the driving rod.

[0011] By adopting the above technical scheme, when the transfer device is docked with the transfer tube and the bottom of the mounting block is fitted with the top of the transfer tube, it is only necessary to start the motor to drive the driving rod to rotate, and use the part of the driving rod that is meshed with the three-ring ring to drive the three-ring ring to rotate. At the same time, the inner rotating rod, the outer rotating rod and the tube wall rotating rod rotate together, so that the protruding part of the docking cam rotates inward, and the tops of the three docking cams are respectively abutted against the bottom of the outer edge of the transfer tube, the bottom of the outer edge of the liquid suction push tube and the bottom of the outer edge of the inner connecting tube. At this time, the liquid suction piston can be driven upward by moving the outer push tube upward, and the exhaust piston can be driven upward by moving the inner connecting tube upward.

[0012] The present invention is further configured as follows: a driving mechanism 1 includes a moving disk slidably arranged in an installation cavity, a transfer screw is fixed on the inner wall of the installation block in the installation cavity, the transfer screw and the outer peripheral wall of the moving disk are threadedly matched, a connecting rod is fixed at the bottom of the moving disk, a plurality of wedge blocks are elastically connected to the outer wall of the connecting rod, an outer push disk is sleeved under the wedge block outside the connecting rod, a synchronization ring is also fixed on the outer wall of the connecting rod, the synchronization ring is located at the bottom of the outer push disk, an outer push cylinder is fixed at the bottom of the outer push disk, a lower pressure ring is integrally formed inside the bottom end of the outer push cylinder, a liquid suction push cylinder is abutted at the bottom of the lower pressure ring, and a liquid suction piston is fixed to the bottom of the liquid suction push cylinder. In this embodiment, a motor 2 (not marked in the figure) is connected to the transfer screw.

[0013] By adopting the above technical solution, it is only necessary to start the second motor and rotate the transfer screw to move the movable plate upward and the connecting rod upward together. At this time, the top of the synchronization ring abuts the outer push plate upward, so that the outer push plate moves upward, and the outer push plate moves upward to drive the outer push tube to move upward together, so that the aspiration piston can be pulled up to aspirate. After the aspiration is completed, the transfer tube is aligned with the new sample bottle by controlling the operating arm, and then the movable plate is moved downward by reversing the transfer screw. At this time, the outer push plate is also pushed down together under the obstruction of the wedge block, so that the outer push plate moves downward and the outer push tube moves downward together. At this time, the lower pressure ring pushes the aspiration push tube downward, so that the aspiration piston moves downward, thereby pushing out the liquid in the transfer tube.

[0014] The present invention is further configured as follows: the second driving mechanism includes an inner push plate arranged at the bottom of the connecting rod and sliding in the outer push cylinder, an inner connecting cylinder is fixed at the bottom of the inner push plate, an exhaust rod is slidably arranged in the inner connecting cylinder, the exhaust piston is fixed at the bottom of the exhaust rod, an exhaust chamfer is provided at the top of the exhaust piston, an upper retaining ring is fixed in the liquid suction push cylinder above the exhaust chamfer, an expansion hole is provided at the bottom of the liquid suction piston below the exhaust piston, an interception plate is fixedly connected to the bottom of the expansion hole, and a plurality of air holes for exhausting gas are provided at the bottom of the liquid suction piston.

[0015] By adopting the above technical solution, as the suction piston continues to move downward to the lower end, the transfer screw continues to rotate, and the suction piston reaches the lower end and cannot move, but the movable plate continues to move downward, forcing the wedge block to retract inward, so that the inner push plate moves downward alone. During the downward movement, the gas inside the outer push tube is compressed downward, and the pressure increases, pushing the exhaust piston to slide downward in the suction piston. At the same time, the exhaust rod slides downward in the inner connecting tube. When the exhaust piston slides to the point where the exhaust chamfer is connected to the flared hole, the airway is opened, and the gas inside the outer push tube can be discharged through the air hole and blown onto the filter, blowing off the residual liquid.

[0016] The present invention is further configured as follows: a telescopic push rod for blocking the outer push plate is arranged in the installation cavity. In this embodiment, a motor three (not marked in the figure) is connected to the telescopic push rod.

[0017] By adopting the above technical solution, after the blowing is completed, the transfer device is removed, and when the liquid suction piston reaches the bottom position, the outer push plate also returns to the original position. At this time, motor three is started, and the outer push plate is blocked at the current position by extending the telescopic push rod, and the movable plate is moved to the original position alone by rotating the transfer screw until the end of the inner rotating rod is engaged with the inner ring of the three-ring ring. At this time, the three-ring ring is rotated by the driving rod, so that all the inner rotating rods, outer rotating rods and cylinder wall rotating rods rotate together, thereby driving the docking cams at the bottom of each to rotate, so that the docking cams rotate and turn away from the bottom, thereby releasing the transfer tube, the liquid suction push tube and the exhaust rod. At this time, the transfer tube can fall off by itself, thereby realizing automatic detachment. If the transfer device is set to multiple heads, multiple samples can be transferred and filtered at one time.

[0018] The present invention is further configured as follows: a solvent bottle placement circle, a mixed liquid placement circle and a pinhole positioning plate are arranged on the top of the processing table, and a flexible operation area is also arranged on the top of the processing table.

[0019] By adopting the above technical solution, the setting of the solvent bottle placement ring and the mixed liquid placement ring ensures that the solvent bottle and the mixed liquid can be firmly placed in the designated position during operation, avoiding the solvent bottle and the mixed liquid from tipping over or rolling due to improper placement, thereby reducing the risk of solvent leakage.

[0020] The setting of the pinhole positioning plate enables the needle to be inserted into the specified position accurately and stably, reducing deviations and errors during the needle insertion process and improving the accuracy and reliability of the experiment.

[0021] The setting of the flexible operation area ensures that experimenters have sufficient space and convenience when conducting experimental operations, thereby improving the efficiency and success rate of experimental operations.

[0022] The present invention is further configured as follows: the processing station door bodies are arranged at both ends of the transparent cover body, and the top surface of the processing station is provided with a recovery groove.

[0023] By adopting the above technical solution, the setting of the recovery tank can not only protect the environment from pollution, but also save resources and reduce costs, while ensuring the convenience and safety of operation, which is very convenient.

[0024] The beneficial effects of the present invention are: 1. When caring for organic matter, most of the organic pretreatment work can be completed through the cooperation of the operating arm and manual labor, which is suitable for the pretreatment requirements of most liquid chromatography or liquid chromatography-mass spectrometry instruments, facilitates subsequent work, and avoids harming the health of the staff.

[0025] 2. Air can be pumped into the filter to blow out the residual sample in the filter, greatly reducing sample carryover. At the same time, when blowing, there is no need to leave the sample bottle and inhale and blow out again. After the transfer and injection are completed, the residue can be blown out immediately, reducing the intermediate steps, without the need for re-alignment, and improving efficiency. At the same time, it can prevent the sample that is inhaled again after the transfer from dripping onto the table, which is conducive to the cleanliness of the processing table, avoiding the large-scale emission of harmful substances, and reducing the probability of operational errors. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is a schematic diagram of the overall structure of the present invention; Figure 2 This is a schematic diagram of the structure of the transfer device of the present invention from an upward angle; Figure 3 It is a schematic diagram of the structure of the transfer device of the present invention from a side top view; Figure 4 It is a schematic diagram of a half-section structure of the transfer device of the present invention from a side top view; Figure 5 The transfer device of the present invention Figure 4 A schematic diagram of the enlarged structure of the middle part A; Figure 6 The transfer device of the present invention Figure 4 The enlarged structural diagram of the middle B part; Figure 7 This is a schematic diagram of a half-section structure of the transfer device of the present invention from a front view; Figure 8 The transfer device of the present invention Figure 7Schematic diagram of the cross-section structure at C in the middle; Fig. 9 The transfer device of the present invention Figure 7 Schematic diagram of the enlarged cross-section structure at point D.

[0027] In the figure: 1, transfer tube; 2, processing table; 3, operating arm; 4, transfer device; 5, transparent cover; 6, built-in gloves; 7, liquid aspiration piston; 8, liquid aspiration push cylinder; 9, exhaust piston; 10, exhaust rod; 11, mounting block; 12, mounting cavity; 13, moving plate; 14, inner push plate; 15, outer push cylinder; 16, inner connection cylinder; 17, outer push plate; 18, solvent bottle placement circle; 19, mixed liquid placement circle; 20, pinhole positioning plate; 21. Flexible operation area; 22. Recovery groove; 23. Expanding hole; 24. Interceptor; 25. Exhaust chamfer; 26. Upper retaining ring; 27. Connecting rod; 28. Telescopic push rod; 29. ​​Docking cam; 30. Inner rotating rod; 31. Outer rotating rod; 32. Cylinder wall rotating rod; 33. Three-ring ring; 34. Driving rod; 35. Wedge block; 36. Synchronous ring; 37. Transfer screw; 38. Aspiration needle; 39. Lower pressure ring; 40. Air hole. DETAILED DESCRIPTION

[0028] In order to make the technical means, creative features, objectives and effects of the present invention easier to understand, the present invention is further described below with reference to specific illustrations.

[0029] like Figure 1 , Figure 2 and Figure 4 As shown, an organic pre-treatment device for liquid chromatography includes a processing table 2, a transparent cover 5 is fixed on the top of the processing table 2, and a plurality of built-in gloves 6 are installed on one side of the transparent cover 5; A plurality of operating arms 3 are installed on the top of the processing table 2, and a transfer device 4 is installed at the output end of one of the operating arms 3. The bottom of the transfer device 4 is connected to a plurality of transfer tubes 1 with aspiration needles 38 at the bottom. A suction piston 7 is slidably arranged inside the transfer tube 1. The suction piston 7 is passed through the middle and a gas exhaust piston 9 is slidably arranged inside. The transfer device 4 includes a mounting block 11, and a plurality of mounting cavities 12 are provided inside the mounting block 11 corresponding to the positions of the plurality of transfer tubes 1. A driving mechanism 1 for driving the suction piston 7 and the exhaust piston 9 to slide is provided in the mounting cavity 12, and a driving mechanism 2 for driving the exhaust piston 9 to slide is provided in the transfer tube 1.

[0030] When performing organic pretreatment, the solvent, beaker and bottle to be used are placed at the designated position of the processing table 2, and then the operating arm 3 is controlled to mix the solvent and extract the required substances in the sample; wherein, by controlling another operating arm 3 equipped with a transfer device 4, the prepared sample can be automatically extracted, transferred and filtered. At the same time, by inserting both hands into the built-in gloves 6, the hands can be inserted into the closed transparent cover 5 to perform some work that cannot be replaced by machines. Through the structure of the present application, when performing organic pretreatment, through the cooperation of manual labor and the operating arm 3, no sample will be left when filtering the sample, so that the sample retention capacity is accurate, the operating burden of the experimenter is reduced, and the probability of operating errors is also reduced. The transparent cover 5 isolates the toxic extractant and the person, so that when the toxic extraction solvent evaporates, it will not cause damage to the respiratory system and nervous system of the human body, and will not endanger the health of the operator, which is very convenient and efficient.

[0031] Specifically, the transfer device 4 can be flexibly moved by controlling the operating arm 3 to place the sample and the transfer tube 1 at the designated position. At the same time, the driving mechanism 1 drives the liquid suction piston 7 to move up and suck the sample to be processed, and then pushes the liquid suction piston 7 down through the driving structure to inject the sucked sample into a new sample bottle through the filter. After the injection, the driving mechanism 2 is used to drive the exhaust piston 9 to slide in the transfer tube 1, and the air in the transfer tube 1 is pumped into the filter to blow out the residual sample in the filter, which greatly reduces the sample carryover. At the same time, when blowing, there is no need to detach from the sample bottle and blow it out again after inhaling. After the transfer and injection are completed, the residue can be blown out immediately, reducing the intermediate steps, eliminating the need for re-alignment, and improving efficiency. At the same time, it is prevented that the sample that is inhaled again after the transfer is completed drips onto the table, which is beneficial to the cleanliness of the processing table 2 and avoids the large-scale emission of harmful substances.

[0032] like Figure 4 As shown, a three-ring ring 33 is rotatably arranged on the outer wall of the outer push tube 15, a driving rod 34 for driving the three-ring ring 33 to rotate is fixed at the bottom of the movable plate 13, and the bottom end of the driving rod 34 is meshed with the inner circle of the outer circle of the three-ring ring 33. A plurality of outer rotating rods 31 are rotatably connected to the inner wall of the outer push tube 15, and the tops of the plurality of outer rotating rods 31 are meshed with the inner circle of the middle circle of the three-ring ring 33. The bottom of the outer push tube 15 is located on the outer rotating rod 31 and a docking cam 29 is fixed thereon. A plurality of outer rotating rods 31 are rotatably arranged in the inner wall of the inner connection tube 16. A plurality of inner rotating rods 30, the tops of the plurality of inner rotating rods 30 are all meshed with the inner ring of the inner ring of the three-ring ring 33, a docking cam 29 is also fixed to the bottom of the cylinder wall of the inner connecting cylinder 16 on the inner rotating rod 30, a plurality of cylinder wall rotating rods 32 are rotatably arranged inside the mounting block 11, the tops of the plurality of cylinder wall rotating rods 32 are meshed with the outer ring of the outer ring of the three-ring ring 33, a docking cam 29 is also fixed to the cylinder wall rotating rod 32 at the bottom of the mounting block 11, and in this embodiment, a motor 1 (not shown in the figure) is connected to the driving rod 34.

[0033] When the transfer device 4 is docked with the transfer tube 1 and the bottom of the mounting block 11 is in contact with the top of the transfer tube 1, it is only necessary to start the motor to drive the driving rod 34 to rotate, and use the part of the driving rod 34 that is meshed with the three-ring ring 33 to drive the three-ring ring 33 to rotate. At the same time, the inner rotating rod 30, the outer rotating rod 31 and the tube wall rotating rod 32 rotate together, so that the protruding part of the docking cam 29 rotates inward, and the tops of the three docking cams 29 are respectively in contact with the bottom of the outer edge of the transfer tube 1, the bottom of the outer edge of the liquid suction push tube 8 and the bottom of the outer edge of the inner connecting tube 16. At this time, the liquid suction piston 7 can be driven to move upward by moving the outer push tube 15 upward, and the exhaust piston 9 can be driven to move upward by moving the inner connecting tube 16 upward.

[0034] Among them, the three-ring ring 33 is set, and the relative position of the three-ring ring 33 and the outer push tube 15 is fixed. Therefore, it can engage with the outer rotating rod 31 and the tube wall rotating rod 32 in the original position and the position after the liquid is discharged, thereby completing the docking and release. The three-ring ring 33 does not need to rotate a full circle, but only needs to rotate a specific angle to achieve the reversal of the docking cam 29. Therefore, the three-ring ring 33 is connected to the upper and lower end devices through the connecting rod 27 without affecting the use of the three-ring ring 33. The overall structure is compact and fully functional, which greatly improves the safety of organic pretreatment, and has a high degree of automation, which is more convenient and efficient.

[0035] like Figure 4 , Figure 5 and Figure 6 As shown, the driving mechanism 1 includes a moving disk 13 slidably arranged in the installation cavity 12, a transfer screw 37 is fixed on the inner wall of the installation block 11 in the installation cavity 12, and the transfer screw 37 is threadedly matched with the outer peripheral wall of the moving disk 13, a connecting rod 27 is fixed at the bottom of the moving disk 13, a plurality of wedge blocks 35 are elastically connected to the outer wall of the connecting rod 27, an outer push disk 17 is sleeved below the wedge blocks 35 outside the connecting rod 27, a synchronization ring 36 is also fixed on the outer wall of the connecting rod 27, the synchronization ring 36 is located at the bottom of the outer push disk 17, an outer push tube 15 is fixed to the bottom of the outer push disk 17, a lower pressure ring 39 is integrally formed inside the bottom end of the outer push tube 15, the bottom of the lower pressure ring 39 abuts against the liquid suction push tube 8, and the liquid suction piston 7 is fixed to the bottom of the liquid suction push tube 8. In this embodiment, a motor 2 (not shown in the figure) is connected to the transfer screw.

[0036] Just start the motor 2 and let the transfer screw rotate, so that the moving disk 13 moves up and the connecting rod 27 moves up together. At this time, the top of the synchronization ring 36 abuts the outer push disk 17 upward, so that the outer push disk 17 moves up, and the outer push disk 17 moves up and drives the outer push tube 15 to move up together, so that the liquid aspiration piston 7 can be pulled up to aspirate. After the aspiration is completed, the transfer tube 1 is aligned with the new sample bottle by controlling the operating arm 3, and then the moving disk 13 is moved down by reversing the transfer screw 37. At this time, the outer push disk 17 is also pushed down together under the obstruction of the wedge block 35, so that the outer push disk 17 moves down and the outer push tube 15 moves down together. At this time, the lower pressure ring 39 pushes the liquid aspiration push tube 8 downward, so that the liquid aspiration piston 7 moves downward, thereby pushing out the liquid in the transfer tube 1.

[0037] like Figure 4 , Figure 5 , Figure 8 and Fig. 9 As shown, the second driving mechanism includes an inner push plate 14 which is arranged at the bottom of the connecting rod 27 and slides in the outer push tube 15, an inner connecting tube 16 is fixed at the bottom of the inner push plate 14, an exhaust rod 10 is slidably arranged in the inner connecting tube 16, an exhaust piston 9 is fixed at the bottom of the exhaust rod 10, an exhaust chamfer 25 is provided on the top of the exhaust piston 9, an upper retaining ring 26 is fixed in the liquid suction push tube 8 above the exhaust chamfer 25, a flared hole 23 is provided at the bottom of the liquid suction piston 7 below the exhaust piston 9, an intercepting plate 24 is fixedly connected to the bottom of the flared hole 23, and a plurality of air holes 40 for exhausting gas are provided at the bottom of the liquid suction piston 7.

[0038] As the suction piston 7 continues to move downward to the lower end, the transfer screw 37 continues to rotate, and the suction piston 7 reaches the lower end and cannot move, but the movable plate 13 continues to move downward, forcing the wedge block 35 to retract inward, so that the inner push plate 14 moves downward alone. During the downward movement, the gas inside the outer push tube 15 is compressed downward, and the pressure increases, pushing the exhaust piston 9 to slide downward in the suction piston 7. At the same time, the exhaust rod 10 slides downward in the inner connecting tube 16. When the exhaust piston 9 slides to the point where the exhaust chamfer 25 is connected to the flared hole 23, the airway is opened, and the gas inside the outer push tube 15 can be discharged through the air hole 40 and blown onto the filter to blow off the residual liquid.

[0039] like Figure 4 As shown, a telescopic push rod 28 for blocking the outer push plate 17 is provided in the installation cavity 12. In this embodiment, a motor 3 (not shown in the figure) is connected to the telescopic push rod 28.

[0040] After the blowing is completed, the transfer device 4 is removed. When the liquid suction piston 7 reaches the bottom position, the outer push plate 17 also returns to the original position. At this time, the motor three is started, and the outer push plate 17 is blocked at the current position by extending the telescopic push rod 28, and the movable plate 13 is moved to the original position alone by rotating the transfer screw 37 until the end of the inner rotating rod 30 is engaged with the inner circle of the three-ring ring 33. At this time, the three-ring ring 33 is rotated by the driving rod 34, so that all the inner rotating rods 30, the outer rotating rods 31 and the barrel wall rotating rods 32 rotate together, thereby driving the docking cams 29 at the bottom of each to rotate, so that the docking cams 29 rotate and turn away from the bottom, thereby releasing the transfer tube 1, the liquid suction push tube 8 and the exhaust rod 10. At this time, the transfer tube 1 can fall off by itself, thereby realizing automatic detachment. The transfer device 4 is set to be multi-headed so that multiple samples can be transferred and filtered at one time.

[0041] like Figure 1 As shown, a solvent bottle placement circle 18 , a mixed liquid placement circle 19 and a pinhole positioning plate 20 are provided on the top of the processing table 2 , and a flexible operation area 21 is also provided on the top of the processing table 2 .

[0042] The arrangement of the solvent bottle placement ring 18 and the mixed liquid placement ring 19 ensures that the solvent bottle and the mixed liquid can be firmly placed at the designated position during operation, avoiding the solvent bottle and the mixed liquid from tipping over or rolling due to improper placement, thereby reducing the risk of solvent leakage.

[0043] The provision of the pinhole positioning plate 20 enables the needle to be accurately and stably inserted into the designated position, reduces deviations and errors during the needle insertion process, and improves the accuracy and reliability of the experiment.

[0044] The setting of the flexible operation area 21 ensures that the experimenter has enough space and convenience when performing the experiment, thereby improving the efficiency and success rate of the experiment.

[0045] like Figure 1 As shown, the doors of the processing station 2 are located at both ends of the transparent cover 5, and a recovery groove 22 is provided on the top surface of the processing station 2.

[0046] The provision of the recovery tank 22 not only protects the environment from pollution, but also saves resources and reduces costs, while ensuring convenient and safe operation, which is very convenient.

[0047] The above shows and describes the basic principles, main features and advantages of the present invention. It should be understood by those skilled in the art that the present invention is not limited to the above embodiments. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention. The scope of the present invention is defined by the attached claims and their equivalents.

Claims

1. An organic pretreatment device for liquid chromatography, characterized in that: It comprises a processing table (2), a transparent cover (5) is installed on the top of the processing table (2), and a plurality of built-in gloves (6) are installed on one side of the transparent cover (5); A plurality of operating arms (3) are installed on the top of the processing table (2), wherein a transfer device (4) is installed at the output end of one of the operating arms (3), and the bottom of the transfer device (4) is connected to a plurality of transfer tubes (1) having a liquid aspiration needle (38) at the bottom, and a liquid aspiration piston (7) is slidably provided inside the transfer tube (1), and an exhaust piston (9) is slidably provided inside the liquid aspiration piston (7), and a through-hole is formed in the middle of the liquid aspiration piston (7); The transfer device (4) comprises a mounting block (11), wherein a plurality of mounting cavities (12) are provided inside the mounting block (11) corresponding to the positions of the plurality of transfer tubes (1), wherein a driving mechanism 1 for driving the suction piston (7) and the exhaust piston (9) to slide is provided inside the mounting cavity (12), and a driving mechanism 2 for driving the exhaust piston (9) to slide is provided inside the transfer tube (1).

2. The organic pretreatment device for liquid chromatography according to claim 1, characterized in that: The driving mechanism 1 comprises a movable plate (13) slidably arranged in the mounting cavity (12); a connecting rod (27) is arranged at the bottom of the movable plate (13); a plurality of wedge blocks (35) are elastically connected to the outer wall of the connecting rod (27); an outer push plate (17) is sleeved outside the connecting rod (27) and located below the wedge blocks (35); a synchronizing ring (36) is also arranged on the outer wall of the connecting rod (27); the synchronizing ring (36) is located at the bottom of the outer push plate (17); an outer push cylinder (15) is arranged at the bottom of the outer push plate (17); a lower pressure ring (39) is arranged at the end of the outer push cylinder (15); a liquid suction push cylinder (8) is abutted at the bottom of the lower pressure ring (39); and the liquid suction piston (7) is fixed on the liquid suction push cylinder (8).

3. The organic pretreatment device for liquid chromatography according to claim 2, characterized in that: The second driving mechanism comprises an inner push plate (14) which is arranged at the bottom of the connecting rod (27) and slides in the outer push tube (15); an inner connecting tube (16) is arranged at the bottom of the inner push plate (14); an exhaust rod (10) is slidably arranged in the inner connecting tube (16); and the exhaust piston (9) is fixed to the bottom of the exhaust rod (10).

4. The organic pretreatment device for liquid chromatography according to claim 3, characterized in that: The exhaust piston (9) is provided with an exhaust chamfer (25) at the top, an upper retaining ring (26) is provided in the liquid suction push cylinder (8) above the exhaust chamfer (25), a flared hole (23) is provided at the bottom of the liquid suction piston (7) below the exhaust piston (9), an interception plate (24) is fixedly connected to the bottom of the flared hole (23), and a plurality of air holes (40) for exhausting air are provided at the bottom of the liquid suction piston (7).

5. The organic pretreatment device for liquid chromatography according to claim 3, characterized in that: The outer wall of the outer push tube (15) is rotatably provided with three rings (33), and the inner wall of the outer push tube (15) is rotatably connected with a plurality of outer rotating rods (31), the tops of the plurality of outer rotating rods (31) are all engaged with the inner circles of the middle circles of the three rings (33), and the bottom of the wall of the outer push tube (15) is provided with a docking cam (29) on the outer rotating rods (31).

6. The organic pretreatment device for liquid chromatography according to claim 5, characterized in that: A plurality of inner rotating rods (30) are rotatably arranged inside the wall of the inner connecting tube (16), and the tops of the plurality of inner rotating rods (30) are all meshed with the inner ring of the inner ring of the three-ring ring (33). The inner rotating rods (30) are also provided with the docking cam (29) at the bottom of the wall of the inner connecting tube (16).

7. The organic pretreatment device for liquid chromatography according to claim 6, characterized in that: A plurality of cylinder wall rotating rods (32) are rotatably arranged inside the mounting block (11), the tops of the plurality of cylinder wall rotating rods (32) are meshed with the outer rings of the outer rings of the three-ring ring (33), and the docking cam (29) is also arranged on the cylinder wall rotating rods (32) at the bottom of the mounting block (11).

8. The organic pretreatment device for liquid chromatography according to claim 5, characterized in that: A driving rod (34) for driving the three-ring (33) to rotate is arranged at the bottom of the movable plate (13), and one end of the driving rod (34) is meshed with the inner ring of the outer ring of the three-ring (33).

9. The organic pretreatment device for liquid chromatography according to claim 2, characterized in that: A telescopic push rod (28) for blocking the outer push plate (17) is arranged in the installation cavity (12).

10. The organic pretreatment device for liquid chromatography according to claim 1, characterized in that: The top of the processing table (2) is provided with a solvent bottle placement circle (18), a mixed liquid placement circle (19) and a pinhole positioning plate (20), and the top of the processing table (2) is also provided with a flexible operation area (21).

11. The organic pretreatment device for liquid chromatography according to claim 1, characterized in that: The door bodies of the processing platform (2) are arranged at both ends of the transparent cover body (5), and a recovery groove (22) is provided on the top surface of the processing platform (2).

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