A Mycobacterium tuberculosis collection and pretreatment device based on tongue swab specimens

Abstract

The present invention belongs to the field of Mycobacterium tuberculosis detection, and specifically relates to a Mycobacterium tuberculosis collection and pretreatment device based on tongue swab specimens, which includes a sampling tube, a sealing cap and a sampling swab. The sampling tube is threadedly connected to the sealing cap. The sampling swab is arranged in the middle of the sealing cap and extends into the sampling tube. An injection mechanism is arranged in the sealing cap, and a culture solution is stored in the injection mechanism. The sampling swab includes a vertical rod and a sampling plate. The vertical rod is a hollow mechanism and is connected to the injection mechanism. The sampling plate is arranged at the sampling end of the vertical rod. The present invention can realize the collection and pretreatment of Mycobacterium tuberculosis tongue swab samples and improve the sampling rate of the samples.

Description

Technical Field

[0001] The present invention belongs to the field of Mycobacterium tuberculosis detection, and particularly relates to a device for collecting and preprocessing Mycobacterium tuberculosis based on tongue swab specimens. Background Art

[0002] Tongue swabbing is a sampling method for Mycobacterium tuberculosis detection. When collecting specimens, the patient needs to open the mouth and expose the oral cavity so that medical staff or laboratory technicians can gently wipe the surface of the patient's tongue with a cotton swab to obtain secretions, and store the secretions in a sealed sampling tube for convenient later detection.

[0003] However, there is currently no dedicated tongue swab device for collecting and preprocessing Mycobacterium tuberculosis. The main purposes of preprocessing are two: (1) removing miscellaneous bacteria other than mycobacteria (decontamination); (2) liquefying the specimen for convenient detection. Chinese Utility Model Patent CN217006494U discloses an auxiliary device applicable to the collection and preprocessing of sputum specimens, which can only collect and preprocess sputum specimens, but is not applicable to the collection of samples on the tongue surface. Since the collection of samples on the tongue surface requires considering the collection of multiple parts of the tongue surface to improve the sampling rate, the sampling ability of conventional cotton swabs is limited, and the preprocessing of samples on the tongue surface cannot be achieved.

[0004] Therefore, how to provide a device for collecting and preprocessing Mycobacterium tuberculosis based on tongue swab specimens has become a problem that needs to be considered by those skilled in the art. Summary of the Invention

[0005] In view of the problems mentioned in the background art, the present invention discloses a device for collecting and preprocessing Mycobacterium tuberculosis based on tongue swab specimens. By setting a sampling plate, the present invention improves the sampling area of the swab, and by connecting the sampling swab to an injection mechanism, the preprocessing of the specimen is realized. The following technical solutions are specifically disclosed:

[0006] A device for collecting and preprocessing Mycobacterium tuberculosis based on tongue swab specimens, comprising a sampling tube, a sealing cap, and a sampling swab. The sampling tube is threadedly connected to the sealing cap. The sampling swab is arranged in the middle of the sealing cap and extends into the sampling tube. An injection mechanism is arranged in the sealing cap, and a culture solution is stored in the injection mechanism. The sampling swab includes a vertical rod and a sampling plate. The vertical rod is a hollow structure and is connected to the injection mechanism, and the sampling plate is arranged at the sampling end of the vertical rod.

[0007] Further, the sampling plate is rectangular, a connecting tube is arranged in the middle of the sampling plate, the connecting tube is sleeved on the vertical rod, and a rubber anti-slip layer is arranged in the connecting tube.

[0008] Further, a partition is provided in the middle of the sampling tube. A through hole is provided in the middle of the partition corresponding to the vertical rod, and transverse holes for the sampling plate to pass through are provided on both sides of the through hole.

[0009] Further, a protective protrusion is provided at the top of the sampling plate.

[0010] Further, fluff inclined towards the sealing cover is provided on both sides of the sampling plate.

[0011] Further, the injection mechanism includes a liquid sac and a push switch. The liquid sac is arranged in the sealing cover, the push switch is arranged at the top of the liquid sac, a chute is provided on one side of the sealing cover, and the push switch is limited in the chute.

[0012] Further, a rubber film for sealing is provided at the end of the vertical rod.

[0013] Further, a conical protrusion is provided at the bottom of the sampling tube corresponding to the rubber film.

[0014] Further, the top of the conical protrusion is hollow, and a liquid outlet hole communicating with the top of the conical protrusion is provided at the bottom of the conical protrusion.

[0015] The beneficial effects of the present invention are as follows: Through the structural design of integrating the sealing cover and the sampling swab, the present invention occupies a small space, can separately protect the sampling plate and the culture medium, and avoid contamination. By providing an injection mechanism in the sealing cover, the pretreatment of Mycobacterium tuberculosis can be realized through the injection mechanism, and the treated culture medium can be collected after standing. The sampling plate adopts a double-sided rectangular structural design, which increases the sampling area and can quickly collect samples on the surface of the tongue. Description of the Drawings

[0016] Figure 1 Schematic diagram of the main body of the present invention;

[0017] Figure 2 Schematic diagram of the structure of the sealing cover and the sampling swab of the present invention;

[0018] Figure 3 Cross-sectional view of the present invention;

[0019] Figure 4 is Figure 3 Partial enlarged view at A in

[0020] Figure 5 Schematic diagram of the partition structure of the present invention;

[0021] Figure 6 Schematic diagram of the conical protrusion structure of the present invention;

[0022] Figure 7 Side view of the sampling plate of the present invention;

[0023] Figure 8 is Figure 7 Partial enlarged view at position B in

[0024] Figure 9 Cross-sectional view of the sealing cover in Embodiment 2 of the present invention;

[0025] Figure 10 is Figure 9 Partial enlarged view at position C in

[0026] Figure 11 Schematic diagram of the clamping block structure in Embodiment 2 of the present invention.

[0027] Wherein, 1 - sampling tube; 2 - sealing cover; 3 - vertical rod; 4 - sampling plate; 5 - partition board; 6 - protective protrusion; 7 - liquid sac; 8 - push switch; 9 - conical protrusion; 10 - liquid outlet hole; 11 - elastic telescopic rod; 12 - clamping groove; 13 - clamping block; 14 - fluff. Detailed implementation manners

[0028] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0029] Embodiment 1

[0030] As Figures 1 - 8 shown, this embodiment discloses a Mycobacterium tuberculosis collection and pretreatment device based on a tongue swab specimen, including a sampling tube 1, a sealing cover 2 and a sampling swab. The sampling tube 1 is threadedly connected to the sealing cover 2. The sampling swab is arranged in the middle of the sealing cover 2 and extends into the sampling tube 1. An injection mechanism is arranged in the sealing cover 2, and a culture solution is stored in the injection mechanism. The culture solution can be 4% NaOH digestion solution or NALC-NaOH solution. The sampling swab includes a vertical rod 3 and a sampling plate 4. The vertical rod 3 is a hollow mechanism and is connected to the injection mechanism. The sampling plate 4 is arranged at the sampling end of the vertical rod 3.

[0031] In order to facilitate the fixation of the sampling swab, a partition board 5 is arranged in the middle of the inside of the sampling tube 1. A through hole corresponding to the vertical rod 3 is arranged in the middle of the partition board 5. Transverse holes for the sampling plate 4 to pass through are arranged on both sides of the through hole. The arrangement of the partition board 5 improves the fixation effect of the sampling swab in the sampling tube 1, avoids the sampling plate 4 touching the tube wall, resulting in the residual of the sampling specimen on the tube wall. The residual specimen is difficult to be infiltrated by the culture solution, which has a certain safety risk. And after the sample stands still, the partition board 5 can be rotated and pulled up to clamp the sampling plate 4, so as to remove the sampling plate 4 from the vertical rod 3.

[0032] Specifically, the sampling plate 4 is rectangular, a connecting pipe is arranged in the middle of the sampling plate 4, a rubber anti-slip layer is arranged in the connecting pipe, the sampling plate 4 is sleeved on the vertical rod 3 through the connecting pipe, and the rubber anti-slip layer is arranged to prevent the sampling plate 4 from easily sliding relative to the vertical rod 3; fluff 14 inclined towards the sealing cover 2 is arranged on both sides of the sampling plate 4, scraping is performed from the inside to the outside of the tongue during sampling, and both sides of the sampling plate 4 can be sampled, improving the sampling rate; a diagonal protection protrusion 6 is arranged at the top of the sampling plate 4, so that when the sampling plate 4 passes through the partition plate 5, it can well prevent the sample on the surface from touching the partition plate 5 after the sampling plate 4 samples.

[0033] As a preferred embodiment of the present invention, the injection mechanism includes a liquid sac 7 and a push switch 8. The liquid sac 7 is arranged in the sealing cover 2. In this embodiment, the liquid sac 7 is an inverted corrugated soft rubber bottle structure. The push switch 8 is arranged at the top of the liquid sac 7, and a chute is arranged on one side of the sealing cover 2. The push switch 8 is limited in the chute.

[0034] As a preferred embodiment of the present invention, a rubber film for sealing is arranged at the end of the vertical rod 3, and a conical protrusion 9 is arranged at the bottom end of the sampling tube 1 corresponding to the rubber film. Specifically, the top of the conical protrusion 9 is hollow, and a liquid outlet hole 10 communicating with the top of the conical protrusion 9 is arranged at the bottom of the conical protrusion 9.

[0035] In this embodiment, the sampling swab is usually stored in the sampling tube 1, and the mouth of the sampling tube 1 is sealed by the sealing cover 2 to avoid contamination. At this time, the rubber film just cannot touch the conical protrusion 9, and the culture solution is sealed in the liquid sac 7. When sampling is required, only the sampling swab needs to be taken out, and the medical staff wipes and samples from the surface of the patient's tongue from the inside to the outside. After sampling, the sampling swab is put into the sampling tube 1, and the push switch 8 is pushed downward to make the bottom rubber film bulge and touch the conical protrusion 9. The rubber film is punctured, and the culture solution flows into the sampling tube 1 along with the downward movement of the push switch 8 until it submerges the sampling plate 4. The sealing cover 2 is tightened to form a sealed environment. After standing and mixing for a period of time, the sealing cover 2 is loosened, and the push switch 8 is pushed upward to suck the mixed culture solution into the liquid sac 7 through the hollow vertical rod 3. The vertical rod 3 is pulled upward and rotated by a certain angle, and the sampling plate 4 can be removed from the vertical rod 3 by using the partition plate 5, which is convenient for the vertical rod 3 to inject the mixed culture solution into other test tubes.

[0036] Embodiment 2

[0037] Such as Figures 9 - 11As shown in the figure, the difference between this embodiment and Embodiment 1 is that in this embodiment, an elastic telescopic rod 11 is connected to the inner side of the push switch 8, and the push switch 8 is installed at the end of the piston rod of the elastic telescopic rod 11. In order to realize the locking of the position of the liquid sac 7 at any time, clamping grooves 12 are longitudinally and evenly arranged on the inner side surface of the sealing cover 2, and clamping blocks 13 are correspondingly arranged on the piston rod of the ejection telescopic rod 11. In the normal state, the clamping blocks are locked in the clamping grooves 12 under the push of the piston rod of the elastic telescopic rod 11, so that the liquid sac 7 cannot move. When it is necessary to push out the culture solution, press the push switch 8 inward, the clamping blocks 13 will simultaneously disengage from the clamping grooves, and then toggle the push switch 8 downward to push the culture solution into the sampling tube 1.

[0038] The above are only preferred embodiments of the present invention, and do not impose any limitation on the technical scope of the present invention. Therefore, any minor modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention still belong to the scope of the technical solution of the present invention.

Claims

1. A device for collecting and pre-processing Mycobacterium tuberculosis based on tongue swab specimens, characterized in that: The sampling swab comprises a sampling tube, a sealing cover and a sampling swab, wherein the sampling tube is threadedly connected to the sealing cover, the sampling swab is arranged in the middle of the sealing cover and extends into the sampling tube, an injection mechanism is arranged in the sealing cover, and a culture fluid is stored in the injection mechanism, the sampling swab comprises a vertical rod and a sampling plate, the vertical rod is a hollow mechanism and is connected to the injection mechanism, and the sampling plate is arranged at the sampling end of the vertical rod; The sampling plate is rectangular, a connecting pipe is provided in the middle of the sampling plate, the connecting pipe is sleeved on the vertical rod, and a rubber anti-slip layer is provided inside the connecting pipe; A partition is provided in the middle of the sampling tube, a through hole is provided in the middle of the partition corresponding to the vertical rod, and transverse holes for the sampling plate to pass through are provided on both sides of the through hole; The injection mechanism includes a liquid capsule and a push switch, wherein the liquid capsule is arranged in the sealing cover, the push switch is arranged at the top of the liquid capsule, a slide groove is arranged on one side of the sealing cover, the push switch is confined in the slide groove, an elastic telescopic rod is connected to the inner side of the push switch, and the push switch is installed at the end of the piston rod of the elastic telescopic rod. In order to realize the locking of the liquid capsule position at any time, the inner side surface of the sealing cover is evenly provided with a clamping groove in the longitudinal direction, and a clamping block is correspondingly arranged on the piston rod of the ejection telescopic rod; The end of the vertical rod is provided with a rubber film for sealing; The bottom end of the sampling tube is provided with a conical protrusion corresponding to the rubber film.

2. A Mycobacterium tuberculosis collection and pretreatment device based on tongue swab specimens according to claim 1, characterized in that: A protective protrusion is arranged on the top of the sampling plate.

3. The device for collecting and pre-processing Mycobacterium tuberculosis based on tongue swab specimens according to claim 1, characterized in that: Both sides of the sampling plate are provided with fluff inclined toward the sealing cover.

4. The device for collecting and pre-processing Mycobacterium tuberculosis based on tongue swab specimens according to claim 1, characterized in that: The top of the conical protrusion is hollow, and the bottom of the conical protrusion is provided with a liquid outlet hole connected with the top of the conical protrusion.

Images