Dissociation liquid, kit and detection method for detecting progesterone in serum

A dissociation solution with methanandrolone and/or dihydrotestosterone enhances progesterone detection sensitivity and accuracy by fully dissociating bound progesterone, addressing the limitations of existing methods.

CN119246870APending Publication Date: 2025-01-03CHONGQING XINSAIYA BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202411438672.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-10-15
Publication Date
2025-01-03

AI Technical Summary

Technical Problem

Existing methods for detecting progesterone in serum face challenges due to progesterone being predominantly bound to corticosteroid binding protein and albumin, leading to reduced sensitivity and accuracy in detection.

Method used

A dissociation solution comprising a buffer, a dissociation agent (methanandrolone and/or dihydrotestosterone), and a preservative (Proclin-300) is used to fully dissociate bound progesterone, improving detection sensitivity and accuracy.

Benefits of technology

The solution achieves high sensitivity and accuracy in progesterone detection, with correlation coefficients ranging from 0.9752 to 0.9989, demonstrating effective dissociation of bound progesterone across various concentration ranges.

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Abstract

The invention belongs to the technical field of sex hormone detection, and particularly relates to a dissociation liquid, a kit and a detection method for detecting progesterone in serum, the dissociation liquid comprises a buffer solution, a dissociation agent and a first preservative; wherein mestanolone and / or dihydrotestosterone is selected as the dissociation agent. Detection is carried out after a progesterone serum sample is treated with the dissociation liquid, the detection value and the sample value are not greatly different, and the dissociation liquid has high accuracy and sensitivity.
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