A whole body light emitting transdermal fiber puncture device

Abstract

The application discloses a whole light-emitting transdermal optical fiber puncture device, which comprises a rod-shaped puncture component for puncture and a light-emitting optical fiber arranged in the puncture component; the end and the side wall of the light-emitting optical fiber are both light-transmitting; the light-emitting optical fiber is provided with reflecting lenses at two ends to form an optical resonant cavity, so that light dispersion is formed in the light-emitting optical fiber; the light emitted by the light-emitting optical fiber can penetrate the side wall of the puncture component; the puncture component comprises a split rod part and a puncture needle; the rod part is made of a light-transmitting material. The light-emitting optical fiber with the light-transmitting end and side wall and the reflecting lenses at the end form the optical resonant cavity, so that the light entering the light-emitting optical fiber forms light dispersion and the light-emitting optical fiber uniformly emits light. The light emitted by the light-emitting optical fiber can penetrate the side wall of the puncture component and act on the tumor, so that the area of photodynamic chemical reaction is increased and the treatment efficiency is improved.

Description

Technical Field

[0001] This invention belongs to the field of percutaneous puncture technology, and particularly relates to an integral light-emitting percutaneous fiber optic puncture device. Background Technology

[0002] Traditional methods of treating tumors using photodynamic therapy and other optical techniques mostly involve inserting optical fibers through the patient's body's free cavities (such as the nasal cavity and oral cavity), which has significant limitations.

[0003] Photodynamic therapy (PDT) is a novel treatment method that uses a specific wavelength of light to excite a photosensitizer for disease treatment. With the aid of fiber optics, endoscopes, and other interventional techniques, lasers can be guided deep into the body for treatment, avoiding the trauma and pain caused by open-chest or open-abdomen surgery. The laser reacts with the photosensitizer within the tumor tissue, undergoing a photodynamic chemical reaction in the presence of oxygen in the biological tissue, producing singlet oxygen and free radicals, thereby destroying and inducing apoptosis of tumor cells. Currently, it is mainly used to treat tumors in the epidermis or cavities, and also for the treatment of certain precancerous lesions and benign lesions. Compared to traditional therapies, PDT has the advantages of minimal trauma, good targeting, and no drug resistance or toxic side effects. However, because the main wavelength of PDT is concentrated in the red light band of around 600 nanometers, this band experiences significant absorption and loss in the human body, generally only transmitting a few millimeters to tens of millimeters. Therefore, it cannot effectively treat some deep tumors. Furthermore, due to the lack of suitable interventional devices, PDT is ineffective for solid tumors without natural cavities.

[0004] Chinese patent application CN1623516A discloses a special puncture needle for photodynamic therapy, consisting of a transparent needle body and a steel needle core, with a closed needle tip. The needle body is made of transparent rigid plastic (detectable by ultrasound and CT scans), but its diameter is smaller than that of existing puncture needles, thus minimizing damage to normal tissues. The closed needle tip seals the needle cavity, preventing the needle core from directly contacting the tumor tissue. Even if the needle core is removed, it cannot lead to tumor cell implantation and metastasis. During treatment, an optical fiber is inserted, and the columnar light emitter of the optical fiber emits laser light within the transparent and closed needle cavity to irradiate the tumor, achieving the therapeutic purpose. This avoids direct contact between the columnar light emitter of the optical fiber and the tumor tissue, preventing damage or breakage of the optical fiber.

[0005] In the aforementioned prior art, although the puncture needle is made of transparent material, the light transmission efficiency is limited because the optical fiber itself can only emit light at its end.

[0006] For example, Chinese patent application CN109331345B describes a photodynamic therapy diagnostic device capable of fiber optic puncture. By using a tapering process to form a tapered head with an increasingly smaller diameter, the effective light irradiation rate is greatly improved. This facilitates the effective combination of light and photosensitizer, reducing waste of light or photosensitizer, thereby increasing treatment efficacy and reducing costs. More importantly, by controlling the specifications, refractive index, angle of the tapered head or conical tail, and refractive index of the polymer sheath, the main light emitted from the tapered head can be focused on a certain angle range directly in front of it, significantly increasing irradiation efficiency and treatment effect, resulting in less waste of light and photosensitizer and higher effectiveness. By using a tapering process to form a tapered head with an increasingly smaller diameter and controlling the taper angle of the tapered head, the effective light irradiation rate is greatly improved, facilitating the effective combination of light and photosensitizer, reducing waste of light or photosensitizer, thereby increasing treatment efficacy and reducing costs. The straight head can provide auxiliary irradiation to the peripheral area. The spiral metal sheath that wraps around it not only plays an important role in the flexibility and strength of the puncture needle, but more importantly, its length, spiral slit, and the width of the spiral or metal plate all have extremely important auxiliary therapeutic effects in photodynamic tumor treatment. That is, while the cone head emits light, a small amount of light can also be emitted simultaneously from the slit of the metal sheath, thus assisting the cone head in achieving effective treatment of the entire tumor and other parts.

[0007] The aforementioned existing puncture structure is difficult to manufacture and has a complex structure, resulting in high costs. Furthermore, using optical fibers as the puncture point makes actual puncture difficult. Summary of the Invention

[0008] The purpose of this invention is to provide an integral light-emitting percutaneous fiber optic puncture device that partially solves or alleviates the above-mentioned deficiencies in the prior art and can improve the light transmittance of the puncture device.

[0009] To solve the aforementioned technical problems, the present invention specifically adopts the following technical solution: a percutaneous fiber optic puncture device, comprising a rod-shaped puncture component for puncture and a light-emitting fiber disposed within the puncture component; both the end and sidewall of the light-emitting fiber are transparent to light; reflective lenses are provided at both ends of the light-emitting fiber to form an optical resonant cavity, so that light diffuses within the light-emitting fiber; the light emitted by the light-emitting fiber can penetrate the sidewall of the puncture component.

[0010] As an improvement, the sidewall of the light-emitting optical fiber has several light-transmitting windows, and light-emitting end caps are provided on the light-transmitting windows; a light-transmitting hole is opened on the puncture component at a position corresponding to the position of the light-emitting end cap.

[0011] As a further improvement, the light-transmitting window is a cross-section of the sidewall of the light-emitting optical fiber; the light-transmitting window is one or more of the following: circular, square, and regular hexagonal.

[0012] As an improvement, several light-transmitting holes are evenly distributed on the entire sidewall of the puncture component.

[0013] As an improvement, the aperture of the light-transmitting hole is 0.1~1mm, and the spacing between the light-transmitting holes is 1~4mm.

[0014] As an improvement, the light-emitting end cap is embedded in the light-transmitting hole, and the height of the light-emitting end cap is flush with the outer wall of the puncture component.

[0015] As an improvement, the puncture component is integrally formed from stainless steel.

[0016] As an improvement, the puncture component includes a separate rod and a puncture needle; the rod is made of a light-transmitting material, and the puncture needle is made of stainless steel.

[0017] As a further improvement, the puncture needle is made of stainless steel.

[0018] As another further improvement, the rod is made of one of the following materials: YAG transparent ceramic, alumina, or polycarbonate.

[0019] As an improvement, both the puncture needle tip and the rod are provided with positioning steps for mating and connection, so that the puncture needle tip and the rod are bonded together after being positioned by the positioning steps.

[0020] As an improvement, the puncture needle and the rod are connected by a threaded connection.

[0021] As an improvement, a screw hole is provided on the end face of the rod, and a screw that mates with the screw hole is fixedly provided at the tail end of the puncture needle.

[0022] As an improvement, one end of the puncture component is a puncture end, and the other end is a connection end; the connection end is sequentially connected to a conductive optical fiber and an optical fiber connector.

[0023] As an improvement, light-guiding adhesive is filled between the inner wall of the puncture component and the light-emitting optical fiber.

[0024] As an improvement, the light-emitting optical fiber is made by removing the sidewall coating layer from a quartz optical fiber and then polishing it.

[0025] As an improvement, the length of the rod is 5~50mm.

[0026] The advantages of this invention are:

[0027] This invention utilizes a light-emitting optical fiber that is transparent at both its ends and sidewalls, along with a reflecting lens at its end, to form an optical resonant cavity. This allows light entering the fiber to diffuse and uniformly radiate light throughout the fiber. The light emitted from the fiber can penetrate the sidewall of the puncture device and act on the tumor, thereby increasing the area for photodynamic chemical reactions and improving treatment efficiency. Especially when the tumor is large, the fiber can be used for large-area treatment after penetrating the tumor.

[0028] Because existing optical fibers can only emit light at their ends, the puncture device can also only emit light at its ends, resulting in a small effective area. In contrast, the luminescent optical fiber in this invention can emit light as a whole and penetrate the sidewall of the puncture component, allowing a large area of ​​the sidewall of the puncture site to emit light, greatly increasing the light transmittance.

[0029] In addition, the present invention has a simple structure, low cost, and is easy to popularize.

[0030] This invention provides two methods for light emitted from a light-emitting optical fiber to penetrate the sidewall of a puncture component. One method involves the light-emitting optical fiber having several light-transmitting windows on its sidewall, each window fitted with a light-emitting end cap; the puncture component has a light-transmitting hole corresponding to the position of the light-emitting end cap. The other method involves the puncture component comprising a separate rod and a puncture needle; the rod is made of a rigid, light-transmitting material. Both methods allow light emitted from the light-emitting optical fiber to penetrate the sidewall of the puncture component, thus enabling the puncture component to emit light over a large area. Attached Figure Description

[0031] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. In all the drawings, similar elements or parts are generally identified by similar reference numerals. The elements or parts in the drawings are not necessarily drawn to scale. Obviously, the drawings described below are some embodiments of the present invention, and those skilled in the art can obtain other drawings based on these drawings without any creative effort.

[0032] Figure 1a This is a three-dimensional structural diagram of the optical fiber puncture device in Embodiment 1 of the present invention;

[0033] Figure 1b This is a schematic diagram of another example of the optical fiber puncture device in Embodiment 1 of the present invention;

[0034] Figure 2 This is a cross-sectional structural diagram of Embodiment 1 of the present invention;

[0035] Figure 3a for Figure 1a Exploded view of the fiber optic puncture device shown;

[0036] Figure 3b for Figure 1b Exploded view of the fiber optic puncture device shown;

[0037] Figure 4 This is a three-dimensional structural schematic diagram of Embodiment 2 of the present invention;

[0038] Figure 5a This is a schematic diagram of the connection structure between the puncture needle and the shaft in Embodiment 2 of the present invention;

[0039] Figure 5b for Figure 5a A cross-sectional view of the structure shown;

[0040] Figure 6 This is a schematic diagram of another connection structure between the puncture needle and the shaft in Embodiment 2 of the present invention.

[0041] Summary of reference numerals in the attached diagram: 1. Puncture component, 2. Conductive optical fiber, 3. Optical fiber connector, 4. Light-emitting optical fiber, 5. Light-emitting end cap, 6. Reflective lens, 7. Light-transmitting window, 8. Light-transmitting hole; 11. Rod, 12. Puncture needle, 14. Positioning step, 15. Screw hole, 16. Screw. Detailed Implementation

[0042] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0043] In this document, suffixes such as "module," "part," or "unit" used to denote elements are used only for the purpose of illustrative purposes and have no specific meaning in themselves. Therefore, "module," "part," or "unit" may be used interchangeably.

[0044] In this document, the terms "upper," "lower," "inner," "outer," "front," "rear," "one end," and "the other end," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing the present invention and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the present invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0045] In this document, unless otherwise explicitly specified and limited, the terms "installed," "equipped with," "connected," etc., should be interpreted broadly. For example, "connection" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection, a direct connection, or an indirect connection through an intermediate medium; it can be a connection within two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0046] In this document, "and / or" includes any and all combinations of one or more of the listed related items.

[0047] In this article, "multiple" means two or more, that is, it includes two, three, four, five, etc.

[0048] Definition of noun:

[0049] An optical resonant cavity is a cavity in which light waves are reflected back and forth to provide light energy feedback.

[0050] Optical diffuse is the diffusion of light waves from the transmission interface, which can form a columnar light-emitting optical fiber.

[0051] Example 1:

[0052] like Figures 1a to 3b As shown, the present invention provides a percutaneous fiber optic puncture device, specifically a light-transmitting percutaneous fiber optic puncture device, comprising a rod-shaped puncture component 1 for puncture and a light-emitting fiber 4 disposed within the puncture component 1; both the end and sidewall of the light-emitting fiber 4 are light-transmitting; reflective lenses 6 are provided at both ends of the light-emitting fiber 4 to form an optical resonant cavity, so that light is diffused within the light-emitting fiber 4; the light emitted by the light-emitting fiber 4 can penetrate the sidewall of the puncture component 1.

[0053] The principle of this invention lies in the optical resonant cavity formed by the light-emitting optical fiber 4, which is transparent at both ends and sidewalls, and the reflective lens 6 at its end. This allows the light entering the light-emitting optical fiber 4 to diffuse and uniformly emit light throughout the entire fiber. The light emitted by the light-emitting optical fiber 4 can penetrate the sidewall of the puncture component 1 and act on the tumor, thereby increasing the area of ​​photodynamic chemical reaction and improving treatment efficiency.

[0054] Because existing optical fibers can only emit light at their ends, the puncture device can also only emit light at its ends, resulting in a small effective area. In contrast, the luminescent optical fiber 4 in this invention can emit light as a whole and penetrate the sidewall of the puncture component 1, causing a large area of ​​the sidewall of the puncture part to emit light, greatly increasing the light transmittance.

[0055] In order to achieve the purpose of light transmission on the side wall of the puncture component, in this embodiment, the side wall of the light-emitting optical fiber 4 has a plurality of light-transmitting windows 7, and the light-transmitting window 7 is provided with a light-emitting end cap 5; the puncture component 1 has a light-transmitting hole 8 at the position corresponding to the position of the light-emitting end cap 5.

[0056] In this embodiment, the light-emitting optical fiber 4 is made by removing the sidewall coating layer from a quartz optical fiber and then polishing it, with a diameter of 0.15~0.25mm. The sidewall of the light-emitting optical fiber 4 itself is translucent, but the light does not travel in a specific direction after passing through. By cutting a portion of the sidewall of the light-emitting optical fiber 4, the cut end is used as a light-transmitting window 7, and the light-emitting end cap 5 is used to guide the light through the light-transmitting hole 8 to diffuse the light, thus avoiding the light from concentrating at one point and affecting the treatment effect.

[0057] In this embodiment, the light-emitting end cap 5 is a beam-expanding end cap, which diffuses the light within the light-emitting fiber. The light-emitting end cap 5 reduces the optical power density of the light-transmitting window 7 through beam expansion. Specifically, it expands the output beam, making the beam more widely dispersed and covering a larger area when it leaves the light-emitting end cap. The light-emitting end cap 5 is prior art, and its specific structure will not be described in detail here.

[0058] The light-transmitting window 7 can be one or more of the following shapes: circular, square, and regular hexagonal, to allow for better light transmission and to accommodate the light-emitting end cap 5. Of course, the present invention does not limit the specific shape of the light-transmitting window 7, as long as it meets the light transmission requirements and facilitates the installation of the light-emitting end cap 5.

[0059] It is also understandable that, in order to ensure uniform light transmission, several light-transmitting holes 8 are evenly distributed on the side wall of the puncture component. The coverage area of ​​the light-transmitting holes 8 can be adaptively adjusted according to specific needs; that is, the light-transmitting holes 9 can cover the entire side wall of the puncture component 1, or they can only cover a part of it. The length of the entire puncture component 1 can also be adjusted according to actual needs; for example, the length of the rod (excluding the tip used for puncture) is 5~50mm.

[0060] To improve light transmission efficiency, the light-emitting cap 5 is embedded within the light-transmitting hole 8 to avoid being blocked by the side wall of the puncture component 1. Furthermore, to ensure the puncture is not affected, the height of the light-emitting cap 5 is flush with the outer side wall of the puncture component 1. If the light-emitting cap 5 is higher than the outer side wall, it will increase puncture resistance; if it is lower than the outer side wall, it will form a pit, making it difficult to clean residual human tissue after puncture.

[0061] In some embodiments, the spacing between the light-transmitting holes 8 is 1~4mm. Too large a spacing will affect the light transmittance of the entire puncture component, while too small a spacing will affect the strength of the puncture component 1. The aperture of the light-transmitting holes 8 themselves is also 0.1~1mm.

[0062] In this embodiment, since the sidewall has a light-transmitting hole for light transmission, the puncture component 1 itself can be made of stainless steel in one piece, which has high strength and is not easily corroded.

[0063] The puncture component 1 has a puncture end at one end and a connection end at the other; the connection end is sequentially connected to a conductive optical fiber 2 and an optical fiber connector 3. It is understood that the puncture end should be relatively sharp to facilitate puncturing human tissue. The conductive optical fiber 2 and the optical fiber connector 3 are used to connect a light source, allowing light to enter the light-emitting optical fiber. The conductive optical fiber is a traditional optical fiber with a diameter of approximately 0.6 mm, within which light can propagate, with only the end emitting light.

[0064] In addition, in order to position and protect the light-emitting optical fiber 4, light-guiding adhesive is filled between the inner wall of the puncture component 1 and the light-emitting optical fiber 4.

[0065] Example 2:

[0066] This embodiment provides an integral light-emitting percutaneous fiber optic puncture device.

[0067] like Figure 4 As shown, unlike Embodiment 1, in order to achieve overall light transmission of the sidewall of the puncture component 1, the puncture component 1 includes a split rod 11 and a puncture needle 12; the rod 11 is made of a rigid light-transmitting material, such as alumina or polycarbonate, so that the light emitted by the light-emitting optical fiber 4 can directly pass through the rod 11 and act on the lesion.

[0068] Of course, it is understandable that the puncture needle 12, since it does not require light transmission, can be made of stainless steel, thereby increasing its strength and facilitating puncture.

[0069] In addition, such as Figure 5a and Figure 5b As shown, both the puncture needle 12 and the shaft 11 are provided with positioning steps 14 for mating and connection, so that the puncture needle 12 and the shaft 11 are positioned by the positioning steps 14 and then bonded together. Figure 6 As shown, the puncture needle 12 and the rod 11 can also be connected by a threaded connection. Specifically, a threaded hole 15 is opened on the end face of the rod 11, and a screw 16 that mates with the threaded hole 15 is fixedly provided at the tail end of the puncture needle 12. In fact, the connection method of the two components is not limited in this invention, as long as a stable connection is achieved.

[0070] It should be noted that, in this document, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Unless otherwise specified, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes that element.

[0071] The embodiments of the present invention have been described above with reference to the accompanying drawings. However, the present invention is not limited to the specific embodiments described above. The specific embodiments described above are merely illustrative and not restrictive. Those skilled in the art can make many other forms under the guidance of the present invention without departing from the spirit and scope of the claims. All of these forms are within the protection scope of the present invention.

Claims

1. A percutaneous fiber optic puncture device with integrated light emission, characterized in that: The device includes a rod-shaped puncture component for puncture and a light-emitting optical fiber disposed within the puncture component. A light-guiding adhesive is filled between the inner wall of the puncture component and the light-emitting optical fiber. Both the end and sidewalls of the light-emitting optical fiber are translucent. Reflective lenses are provided at both ends of the light-emitting optical fiber to form an optical resonant cavity, causing light dispersion within the fiber. The light emitted by the optical fiber can penetrate the sidewalls of the puncture component. The puncture component includes a separate rod and a puncture needle. The rod is made of a rigid, translucent material, while the needle is made of opaque stainless steel. The rod is made of one of the following materials: YAG transparent ceramic, alumina, or polycarbonate. One end of the puncture component is a puncture end, and the other end is a connection end, wherein the connection end is provided with an optical fiber connector. The light-emitting optical fiber is made by removing the sidewall coating layer from a quartz optical fiber and then polishing it.

2. The integral light-emitting percutaneous fiber optic puncture device according to claim 1, characterized in that: Both the puncture needle and the rod are provided with positioning steps for mating and connection, so that the puncture needle and the rod are bonded together after being positioned by the positioning steps.

3. The integral light-emitting percutaneous fiber optic puncture device according to claim 1, characterized in that: The puncture needle and the shaft are connected by a threaded connection.

4. The integral light-emitting percutaneous fiber optic puncture device according to claim 3, characterized in that: A screw hole is provided on the end face of the rod, and a screw that mates with the screw hole is fixedly provided at the tail end of the puncture needle.

5. The integral light-emitting percutaneous fiber optic puncture device according to claim 1, characterized in that: The fiber optic connector is connected to a conductive fiber.

6. The integral light-emitting percutaneous fiber optic puncture device according to claim 1, characterized in that: The length of the rod is 5~50mm.

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