Anti-wrinkle composition with tender luster and application thereof

Abstract

The invention provides an anti-wrinkle composition with tender luster and application of the anti-wrinkle composition. The anti-wrinkle composition with the tender luster is prepared from the following components in parts by weight: 0.001 to 5 parts of silybum marianum extract, 0.01 to 3 parts of acetyl hydroxyproline, 0.000001 to 0.01 part of tripeptide-2, 0.001 to 1 part of ascorbic acid polypeptide, 0.01 to 1 part of adenosine and a proper amount of solvent. After the silybum marianum extract, the acetyl hydroxyproline, the tripeptide-2, the ascorbic acid polypeptide and the adenosine are matched, the anti-wrinkle composition is applied to cosmetics, the face is more tender and glossy after the anti-wrinkle composition is used, and the anti-wrinkle composition has an excellent anti-wrinkle effect.

Description

Technical Field

[0001] The invention relates to the field of cosmetics, and in particular to an anti-wrinkle composition with a moist and glossy appearance and application thereof. Background Art

[0002] The skin is the largest organ in the human body, covering the entire body. It protects various tissues and organs in the body from physical, mechanical, chemical and pathogenic microorganisms, and maintains the stability of the human body's internal environment. The skin has two barrier functions: on the one hand, it prevents the loss of water, electrolytes, and other substances in the body; on the other hand, it prevents the invasion of harmful substances from the outside.

[0003] In order to maintain the normal physiological functions of the skin and delay skin aging, more and more people have begun to use skin care cosmetics to maintain their skin. In recent years, plant extracts have gradually replaced synthetic chemicals in cosmetics, but the anti-wrinkle effect needs to be improved. Summary of the invention

[0004] The purpose of the present invention is to overcome the shortcomings of the prior art and provide an anti-wrinkle composition with a moist and glossy appearance and its application.

[0005] To achieve the above object, the technical scheme adopted by the present invention is: an anti-wrinkle composition with a moist and radiant luster, the anti-wrinkle composition with a moist and radiant luster comprises the following components in parts by weight: 0.001 to 5 parts by weight of milk thistle extract, 0.01 to 3 parts by weight of acetylhydroxyproline, 0.000001 to 0.01 parts by weight of tripeptide-2, 0.001 to 1 parts by weight of ascorbic acid polypeptide, 0.01 to 1 parts by weight of adenosine and an appropriate amount of solvent.

[0006] Research has found that the above-mentioned anti-wrinkle composition with a moist and radiant glow, after combining milk thistle extract, acetylhydroxyproline, tripeptide-2, ascorbic acid polypeptide and adenosine, has excellent moisturizing effect when applied to cosmetics. After use, the face becomes more moist and radiant, and has excellent anti-wrinkle effect.

[0007] Preferably, the anti-wrinkle composition with a supple and radiant glow comprises the following components in parts by weight: 0.05-4 parts by weight of milk thistle extract, 0.5-3 parts by weight of acetylhydroxyproline, 0.001-0.01 parts by weight of tripeptide-2, 0.1-1 parts by weight of ascorbic acid polypeptide, 0.1-1 parts by weight of adenosine and an appropriate amount of solvent.

[0008] Preferably, the anti-wrinkle composition with a moist and radiant glow comprises the following components in parts by weight: 0.2-4 parts by weight of milk thistle extract, 0.5-3 parts by weight of acetylhydroxyproline, 0.001-0.01 parts by weight of tripeptide-2, 0.1-1 parts by weight of ascorbic acid polypeptide, 0.1-1 parts by weight of adenosine and an appropriate amount of solvent.

[0009] Preferably, the anti-wrinkle composition with a moist and radiant glow comprises the following components in parts by weight: 0.5-3 parts by weight of milk thistle extract, 0.8-2.5 parts by weight of acetylhydroxyproline, 0.003-0.01 parts by weight of tripeptide-2, 0.3-0.8 parts by weight of ascorbic acid polypeptide, 0.3-0.8 parts by weight of adenosine and an appropriate amount of solvent.

[0010] The above-mentioned anti-wrinkle composition with a moist and radiant appearance is prepared by combining milk thistle extract, acetylhydroxyproline, tripeptide-2, ascorbic acid polypeptide and adenosine, optimizing the weight ratio of each component, and applying it to cosmetics. After use, the face becomes more moist and radiant, and has an excellent anti-wrinkle effect.

[0011] The present invention also provides the use of any of the above anti-wrinkle compositions with a moist and radiant luster in the preparation of cosmetics, wherein the cosmetics are cosmetic skin care water, cosmetic emulsion, facial mask or gel.

[0012] The present invention also provides an anti-wrinkle facial lotion with a supple luster, the facial lotion comprising an oil phase and an aqueous phase, the weight ratio of the oil phase to the aqueous phase being (6.5-7.5): (2.5-3.5); The aqueous phase includes the following components in percentage by weight of the aqueous phase: 0.8% to 1.5% of ethyl cellulose, 0.8% to 1.5% of carboxymethyl cellulose, 0.5% to 1% of Tween 80, 0.5% to 1% of hyaluronic acid, 0.003% to 15% of milk thistle extract, 0.03% to 3% of acetylhydroxyproline, 0.000003% to 0.03% of tripeptide-2, 0.003 to 3% of ascorbic acid polypeptide, 0.03% to 3% of adenosine, and the balance of water; The oil phase includes the following components in percentage by weight of the oil phase: 1.5% to 3% squalane, 2.5% to 3.5% jojoba seed oil, 4% to 6% avocado esters, 4% to 6% mango seed esters, 1.5% to 2.5% tocopherol and the balance grape seed oil; The oil phase and the water phase are mixed and homogenized at 18000 r / min-25000 r / min for 2-5 minutes to obtain a facial lotion.

[0013] The facial emulsion oil phase uses grape seed oil as a base component, adds squalane, jojoba seed oil, avocado esters, mango seed esters, and tocopherol as an oil phase, disperses milk thistle extract, acetyl hydroxyproline, tripeptide-2, ascorbic acid polypeptide, and adenosine in an aqueous phase, and adds ethyl cellulose, carboxymethyl cellulose, Tween 80, and hyaluronic acid in the aqueous phase. Ethyl cellulose, carboxymethyl cellulose, Tween 80, and hyaluronic acid are dispersed in an aqueous solution, and after high-speed homogenization with the oil phase using grape seed oil as a base component, a stable water-in-oil Pickering emulsion can be formed, so that the anti-wrinkle facial emulsion with a watery and radiant appearance has a more lasting hydrating effect. After use, the face becomes more watery and radiant, and has an excellent anti-wrinkle effect.

[0014] Preferably, the aqueous phase comprises the following components in weight percentage of the aqueous phase: 0.8% to 1.5% of ethyl cellulose, 0.8% to 1.5% of carboxymethyl cellulose, 0.5% to 1% of Tween 80, 0.5% to 1% of hyaluronic acid, 1.5% to 9% of milk thistle extract, 2.5% to 7.5% of acetylhydroxyproline, 0.01% to 0.03% of tripeptide-2, 0.9% to 2.4% of ascorbic acid polypeptide and 0.9% to 2.4% of adenosine.

[0015] Preferably, the weight ratio of ethyl cellulose, carboxymethyl cellulose and hyaluronic acid is (0.8~1.2):(1~1.5):(0.8~1.0).

[0016] The present invention also provides a method for preparing any of the above-mentioned facial lotions, the method comprising the following steps: (1) Mix the oil phase components according to the weight ratio and homogenize at 40-45°C and 18000-25000 r / min for 2-5 minutes; (2) dissolving the aqueous phase components in deionized water according to weight proportion; (3) The oil phase and the water phase are mixed and homogenized at 18000 r / min to 25000 r / min for 2 to 5 minutes to obtain a facial lotion.

[0017] The preparation method of the facial lotion has simple process, no harsh preparation conditions, and is easy to implement.

[0018] The beneficial effects of the present invention are as follows: the present invention provides an anti-wrinkle composition with a moist and radiant appearance and an application thereof. The anti-wrinkle composition with a moist and radiant appearance combines milk thistle extract, acetylhydroxyproline, tripeptide-2, ascorbic acid polypeptide and adenosine, and is applied to cosmetics to have excellent anti-wrinkle effects. The facial emulsion oil phase of the present invention uses grape seed oil as a base component, adds squalane, jojoba seed oil, avocado esters, mango seed esters, and tocopherol as an oil phase, disperses milk thistle extract, acetyl hydroxyproline, tripeptide-2, ascorbic acid polypeptide, and adenosine in an aqueous phase, and adds ethyl cellulose, carboxymethyl cellulose, Tween 80, and hyaluronic acid in the aqueous phase. Ethyl cellulose, carboxymethyl cellulose, Tween 80, and hyaluronic acid are dispersed in an aqueous solution, and after high-speed homogenization with the oil phase using grape seed oil as a base component, a stable water-in-oil Pickering emulsion can be formed, so that the anti-wrinkle facial emulsion with a tender and radiant complexion has a more lasting moisturizing effect, and the face becomes more tender and radiant after use, and has an excellent anti-wrinkle effect. DETAILED DESCRIPTION

[0019] In order to better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0020] Example 1 As an anti-wrinkle facial lotion with a supple luster as an embodiment of the present invention, the facial lotion comprises an oil phase and a water phase, and the weight ratio of the oil phase to the water phase is 7:3; The aqueous phase includes the following components in percentage by weight of the aqueous phase: 1% ethyl cellulose, 1.2% carboxymethyl cellulose, 0.5% Tween 80, 0.8% hyaluronic acid, 1% milk thistle extract, 0.5% acetyl hydroxyproline, 0.01% tripeptide-2, 0.8% ascorbic acid polypeptide, 0.8% adenosine and the balance water; The oil phase includes the following components in percentage by weight of the oil phase: 1.8% squalane, 3% jojoba seed oil, 5% avocado esters, 5% mango seed esters, 1.5% tocopherol and the balance grape seed oil; The oil phase and the water phase were mixed and homogenized at 20000 r / min for 3 minutes to obtain a facial lotion.

[0021] The preparation method of the facial emulsion of the present embodiment comprises the following steps: (1) The oil phase components were mixed according to the weight ratio and homogenized at 42°C and 20,000 r / min for 2 minutes; (2) dissolving the aqueous phase components in deionized water according to weight proportion; (3) The oil phase and the water phase were mixed and homogenized at 20,000 r / min for 3 minutes to obtain a facial lotion.

[0022] Example 2 As an anti-wrinkle facial lotion with a moist and radiant luster according to an embodiment of the present invention, the only difference between this embodiment and the embodiment is that the weight ratio of the oil phase to the water phase is 6.7:3.3.

[0023] Example 3 As an anti-wrinkle facial lotion with a supple luster as an embodiment of the present invention, the facial lotion comprises an oil phase and a water phase, and the weight ratio of the oil phase to the water phase is 7:3; The aqueous phase includes the following components in percentage by weight of the aqueous phase: 1.2% ethyl cellulose, 1.5% carboxymethyl cellulose, 0.5% Tween 80, 0.8% hyaluronic acid, 1% milk thistle extract, 0.5% acetyl hydroxyproline, 0.01% tripeptide-2, 0.8% ascorbic acid polypeptide, 0.8% adenosine and the balance water; The oil phase includes the following components in percentage by weight of the oil phase: 1.8% squalane, 3% jojoba seed oil, 5% avocado esters, 5% mango seed esters, 1.5% tocopherol and the balance grape seed oil; The oil phase and the water phase were mixed and homogenized at 20000 r / min for 3 minutes to obtain a facial lotion.

[0024] Example 4 As an anti-wrinkle facial lotion with a supple luster as an embodiment of the present invention, the facial lotion comprises an oil phase and a water phase, and the weight ratio of the oil phase to the water phase is 7:3; The aqueous phase includes the following components in percentage by weight of the aqueous phase: 1.2% ethyl cellulose, 1.2% carboxymethyl cellulose, 0.5% Tween 80, 0.8% hyaluronic acid, 3% milk thistle extract, 3% acetyl hydroxyproline, 0.02% tripeptide-2, 1.2% ascorbic acid polypeptide, 1.5% adenosine and the balance water; The oil phase includes the following components in percentage by weight of the oil phase: 1.8% squalane, 3% jojoba seed oil, 5% avocado esters, 5% mango seed esters, 1.5% tocopherol and the balance grape seed oil; The oil phase and the water phase were mixed and homogenized at 20000 r / min for 3 minutes to obtain a facial lotion.

[0025] Example 5 As an anti-wrinkle facial lotion with a supple luster as an embodiment of the present invention, the facial lotion comprises an oil phase and a water phase, and the weight ratio of the oil phase to the water phase is 7:3; The aqueous phase includes the following components in percentage by weight of the aqueous phase: 1.2% ethyl cellulose, 1.2% carboxymethyl cellulose, 0.5% Tween 80, 0.8% hyaluronic acid, 4% milk thistle extract, 5% acetyl hydroxyproline, 0.02% tripeptide-2, 0.9% ascorbic acid polypeptide, 1.2% adenosine and the balance water; The oil phase includes the following components in percentage by weight of the oil phase: 1.8% squalane, 2.5% jojoba seed oil, 4% avocado esters, 6% mango seed esters, 1.5% tocopherol and the balance grape seed oil; The oil phase and the water phase were mixed and homogenized at 20000 r / min for 3 minutes to obtain a facial lotion.

[0026] Comparative Example 1 As an anti-wrinkle facial lotion with a supple luster as an embodiment of the present invention, the facial lotion comprises an oil phase and a water phase, and the weight ratio of the oil phase to the water phase is 7:3; The only difference between this comparative example and Example 3 is that ethyl cellulose is not contained, and the corresponding weight content is supplemented by carboxymethyl cellulose.

[0027] Comparative Example 2 The only difference between this comparative example and Example 3 is that carboxymethyl cellulose is not contained, and the corresponding weight content is supplemented by ethyl cellulose.

[0028] Comparative Example 3 The only difference between this comparative example and Example 3 is that the oil phase does not contain grape seed oil, and the oil phase includes the following components in a weight ratio: 1.8 parts by weight of squalane, 2.5 parts by weight of jojoba seed oil, 4 parts by weight of avocado esters, 6 parts by weight of mango seed esters and 1.5 parts by weight of tocopherol.

[0029] Comparative Example 4 The only difference between this comparative example and Example 3 is that sodium hyaluronate is not contained.

[0030] Comparative Example 5 The only difference between this comparative example and Example 3 is that the milk thistle extract is not contained, and its weight content is supplemented by acetylhydroxyproline, tripeptide-2, ascorbic acid polypeptide and adenosine according to the weight ratio.

[0031] Comparative Example 6 The only difference between this comparative example and Example 3 is that acetylhydroxyproline is not contained, and its content is supplemented by milk thistle extract, tripeptide-2, ascorbic acid polypeptide and adenosine according to weight ratio.

[0032] Experimental methods 1. Dispersion particle size test of emulsion The anti-wrinkle facial emulsions with a supple luster of Examples 1 to 4 and Comparative Examples 1, 2, and 4 were diluted to 0.5% with deionized water, and then the particle size and polydispersity index (PDI) of the particles were measured at 25° C. using a Malvern nanoparticle sizer.

[0033] The experimental results are shown in Table 1.

[0034] Table 1 Particle parameters of anti-wrinkle facial lotion with moist and radiant glow

[0035] 2. Experimental Methods (I) The samples to be tested are the anti-wrinkle facial lotions with a moist and radiant appearance according to Examples 1-5 and Comparative Examples 1-6.

[0036] 2. Volunteers and how to use them Chinese male volunteers were selected, aged 45 to 55 years old, with skin pH between 5.2 and 5.6. All volunteers had their skin oil content tested by Sebumeter® method, and 33 volunteers were selected, whose ratio of the range to the average value of skin oil content was no higher than 0.3. They were randomly divided into 9 groups, 3 people in each group.

[0037] Trial method: After washing the face with clean water every morning and evening, the user evenly applies 1.5mL of facial lotion on the face, and uses it once every morning and evening for 45 days. Do not use other skin care products during the trial.

[0038] (III) Anti-wrinkle test The skin rapid imaging analysis system Derma TOP uses fringe projection measurement technology, and obtains wrinkle parameters through one-time positioning of the head and two ear sensors, secondary positioning of the facial laser, camera image capture, three-dimensional skin rapid imaging, and computer image processing. The wrinkle parameters in the 2cmx2cm area of ​​the corners of the eyes (outer canthus) of each subject were obtained, including the number, length, width, and depth of wrinkles. The wrinkle volume in the 2cmx2cm area was obtained using the integral method, where n represents the number of wrinkles, a, b, and c represent the length, width, and depth of wrinkles, respectively. The total of the two eyes was taken, and the wrinkle volume before the trial was V0, and the volume after two months of trial was recorded as V2.

[0039] After 45 days of trial, wrinkle improvement rate = (V0-V2) / V0×100%.

[0040] The results are shown in Table 1, which are the trial results of wrinkle improvement rate %.

[0041] (IV) Moisturizing efficacy test On-site testing was carried out. No cosmetics could be applied to the test area in the morning of the test day. Under the guidance of the staff, the volunteers cleaned the test area with clean water and marked 3cmx3cm experimental areas on the left and right cheeks respectively. The same volunteer smeared the matrix blank sample on the left cheek as a control. The test sample volume for each experimental area was 0.1mL of sample taken with a pipette.

[0042] Before using the product and 3 hours after using the product, the skin moisture of the experimental area was tested using Comeometer CM825. Each experimental area was tested three times and the average value was taken, recorded as T2, and the matrix blank sample was recorded as T1; the data before the test sample was used was recorded as T0, and the data before the matrix sample was used was recorded as T0'.

[0043] Relative change rate (%) = (T2-T0)-(T1-T0') / T0×100%.

[0044] Table 2 Moisturizing and anti-wrinkle effects of facial lotions

[0045] As can be seen from Tables 1 and 2, the oil phase of the facial emulsion of the present invention uses grape seed oil as a base component, adds squalane, jojoba seed oil, avocado esters, mango seed esters, and tocopherol as an oil phase, disperses milk thistle extract, acetyl hydroxyproline, tripeptide-2, ascorbic acid polypeptide, and adenosine in an aqueous phase, and adds ethyl cellulose, carboxymethyl cellulose, Tween 80, and hyaluronic acid in the aqueous phase. Ethyl cellulose, carboxymethyl cellulose, Tween 80, and hyaluronic acid are dispersed in an aqueous solution, and after high-speed homogenization with the oil phase using grape seed oil as a base component, a stable water-in-oil Pickering emulsion can be formed, so that the anti-wrinkle facial emulsion with a tender and shiny luster has a more lasting moisturizing and anti-wrinkle effect.

[0046] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.

Claims

1. An anti-wrinkle composition with a moist and glossy appearance, characterized in that: The anti-wrinkle composition with a supple and glossy appearance comprises the following components in parts by weight: 0.001 to 5 parts by weight of milk thistle extract, 0.01 to 3 parts by weight of acetylhydroxyproline, 0.000001 to 0.01 parts by weight of tripeptide-2, 0.001 to 1 parts by weight of ascorbic acid polypeptide, 0.01 to 1 parts by weight of adenosine and an appropriate amount of solvent.

2. The anti-wrinkle composition having a moist and glossy appearance according to claim 1, characterized in that: The anti-wrinkle composition with a supple and glossy appearance comprises the following components in parts by weight: 0.05-4 parts by weight of milk thistle extract, 0.5-3 parts by weight of acetylhydroxyproline, 0.001-0.01 parts by weight of tripeptide-2, 0.1-1 parts by weight of ascorbic acid polypeptide, 0.1-1 parts by weight of adenosine and an appropriate amount of solvent.

3. The anti-wrinkle composition having a moist and glossy appearance according to claim 1, characterized in that: The anti-wrinkle composition with a supple and glossy appearance comprises the following components in parts by weight: 0.2-4 parts by weight of milk thistle extract, 0.5-3 parts by weight of acetylhydroxyproline, 0.001-0.01 parts by weight of tripeptide-2, 0.1-1 parts by weight of ascorbic acid polypeptide, 0.1-1 parts by weight of adenosine and an appropriate amount of solvent.

4. The anti-wrinkle composition having a moist and glossy appearance according to claim 1, characterized in that: The anti-wrinkle composition with a supple and glossy appearance comprises the following components in parts by weight: 0.5-3 parts by weight of milk thistle extract, 0.8-2.5 parts by weight of acetylhydroxyproline, 0.003-0.01 parts by weight of tripeptide-2, 0.3-0.8 parts by weight of ascorbic acid polypeptide, 0.3-0.8 parts by weight of adenosine and an appropriate amount of solvent.

5. Use of the anti-wrinkle composition with a supple luster as claimed in any one of claims 1 to 4 in the preparation of cosmetics, wherein the cosmetics are cosmetic skin care water, cosmetic emulsion, facial mask or gel.

6. An anti-wrinkle facial lotion with a moist and radiant glow, characterized in that: The facial lotion comprises an oil phase and an aqueous phase, and the weight ratio of the oil phase to the aqueous phase is (6.5-7.5): (2.5-3.5); The aqueous phase includes the following components in percentage by weight of the aqueous phase: 0.8% to 1.5% of ethyl cellulose, 0.8% to 1.5% of carboxymethyl cellulose, 0.5% to 1% of Tween 80, 0.5% to 1% of hyaluronic acid, 0.003% to 15% of milk thistle extract, 0.03% to 3% of acetylhydroxyproline, 0.000003% to 0.03% of tripeptide-2, 0.003 to 3% of ascorbic acid polypeptide, 0.03% to 3% of adenosine, and the balance of water; The oil phase includes the following components in percentage by weight of the oil phase: 1.5% to 3% squalane, 2.5% to 3.5% jojoba seed oil, 4% to 6% avocado esters, 4% to 6% mango seed esters, 1.5% to 2.5% tocopherol and the balance grape seed oil; The oil phase and the water phase are mixed and homogenized at 18000 r / min-25000 r / min for 2-5 minutes to obtain a facial lotion.

7. The anti-wrinkle facial lotion with a moist and radiant luster according to claim 6, characterized in that: The aqueous phase includes the following components in weight percentage of the aqueous phase: 0.8% to 1.5% of ethyl cellulose, 0.8% to 1.5% of carboxymethyl cellulose, 0.5% to 1% of Tween 80, 0.5% to 1% of hyaluronic acid, 1.5% to 9% of milk thistle extract, 2.5% to 7.5% of acetylhydroxyproline, 0.01% to 0.03% of tripeptide-2, 0.9% to 2.4% of ascorbic acid polypeptide and 0.9% to 2.4% of adenosine.

8. The anti-wrinkle facial lotion with a moist and radiant glow according to claim 6, characterized in that: The weight ratio of ethyl cellulose, carboxymethyl cellulose and hyaluronic acid is (0.8~1.2):(1~1.5):(0.8~1.0).

9. The method for preparing a facial lotion as claimed in any one of claims 6 to 8, characterized in that: The preparation method comprises the following steps: (1) Mix the oil phase components according to the weight ratio and homogenize at 40-45°C and 18000-25000 r / min for 2-5 minutes; (2) dissolving the aqueous phase components in deionized water according to weight proportion; (3) The oil phase and the water phase are mixed and homogenized at 18000 r / min to 25000 r / min for 2 to 5 minutes to obtain a facial lotion.

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