Cleaning composition for removing pesticide residues in traditional Chinese medicine, preparation method of cleaning composition and application of cleaning composition in preparation of fifteen-ingredient gentiana scabra bunge pills

Abstract

The invention belongs to the technical field of cleaning agent preparation, and particularly relates to a cleaning composition for removing pesticide residues in traditional Chinese medicine, a preparation method of the cleaning composition and application of the cleaning composition in preparation of fifteen-ingredient gentian flower pills. The cleaning composition is prepared from the following components: tea seeds, orange peel, loofah sponge, citric acid, saponin, fresh ginger, a surfactant, povidone K30 and water, wherein the surfactant is prepared from disodium alcohol ether sulfosuccinate, sophorolipid and dodecyl trimethyl ammonium chloride. The cleaning composition for removing pesticide residues in traditional Chinese medicines is obtained by selecting the specific surfactant according to the synergistic interaction among the alcohol ether sulfosuccinate monoester disodium salt, the sophorolipid and the dodecyl trimethyl ammonium chloride, and the composition greatly improves the removal rate of pesticides in the traditional Chinese medicines in the fifteen-ingredient gentian flower pills, so that the cleaning composition can be used for removing pesticide residues in the traditional Chinese medicines in the fifteen-ingredient gentian flower pills. And the preparation method is simple, low in cost and suitable for industrial production.

Description

Technical Field

[0001] The invention belongs to the technical field of cleaning agent preparation, and particularly relates to a cleaning composition for removing pesticide residues in traditional Chinese medicine, a preparation method thereof, and an application thereof in the preparation of fifteen-flavor gentian flower pills. Background Art

[0002] The fifteen-flavor gentian flower pill is mainly used for fever, cough with sputum, chest tightness and other symptoms caused by lung failure to spread and descend. The prescription is 30-35g of white gentian, 15-20g of sandalwood, 30-35g of terminalia chebula, 20-25g of terminalia chebula, 20-30g of emblica, 20-30g of travertine, 15-20g of costus root, 10-15g of jujube, 5-10g of clove, 5-10g of nutmeg, 20-25g of scutellaria baicalensis, 15-20g of agarwood, 15-20g of baxiaga, 20-25g of mustard, and 15-20g of licorice. At present, wild medicinal materials are far from meeting the market demand, and most Chinese herbal medicines rely on artificial cultivation. In order to ensure the quality and yield of medicinal materials, farmers have to use a large amount of various types of pesticides during the cultivation process. After people take traditional Chinese medicines with excessive pesticide residues, the toxic and harmful components of the pesticides will accumulate in the body. Therefore, the pollution of pesticides in traditional Chinese medicines cannot be ignored.

[0003] The promulgation and implementation of the 2020 edition of the Chinese Pharmacopoeia marks that the state's control over pesticide residues in botanical Chinese medicinal materials has been officially written into the pharmacopoeia. The 2020 edition of the Chinese Pharmacopoeia General Chapter 0212 General Rules for the Inspection of Medicinal Materials and Decoction Pieces stipulates the inspection items for 33 banned pesticides in botanical Chinese medicinal materials and decoction pieces. The 33 banned pesticides are: methyl parathion, methyl parathion, parathion, monocrotophos, phosphamidon, hexachlorhexidine, DDT, chlordimeform, herbicide, aldrin, dieldrin, fenamiphos, fonothion, cadusafos, coumaphos, chlorpyrifos, terbufos, chlorsulfuron, ethametsulfuron, metsulfuron, phorate, methyl isofenphos, demeton, carbofuran, aldicarb, ethoxyproline, chlorfenapyr, isocarb, endosulfan, fipronil, dicofol, thiocarb, and methyl thiocarb. It also stipulates the residue limits of other organochlorine pesticides in the Chinese medicinal materials ginseng, red ginseng, American ginseng, licorice and astragalus, including seven other organochlorine pesticides: hexachlorobenzene, heptachlor, pentachloronitrobenzene, heptachlor epoxide, trans-chlordane, cis-chlordane and chlordane oxide.

[0004] In order to reduce the harm of pesticide residues to human health, detergent cleaning is usually used to clean and remove pesticide residues on the surface of traditional Chinese medicine. Chinese invention patent application CN110467972A discloses a pesticide residue remover and a removal method, wherein the remover comprises three components, the first component is a solution composed of two or more of Na2HPO4, NaHCO3, NaCl, MgCl2, and sodium citrate, the second component is a polyethylene glycol 400 solution, and the third component is a solution composed of two or more of tryptophan, tyrosine, arginine, and histidine. It effectively removes various types of pesticide residues in traditional Chinese medicines and vegetables, has low pesticide residues, has certain sterilization and complexing heavy metal effects, is safe and environmentally friendly, has no toxic effects on the human body, and is widely used in the cleaning of fruits, vegetables, and traditional Chinese medicines.

[0005] Another Chinese invention patent application CN102618399A discloses a composition for removing pesticide residues and disinfecting and a preparation method. The mass percentages of the components of the composition are as follows: 5.0-20.0% biazyme, 0.5-5.0% polyhexamethylene biguanide hydrochloride, 0.5-10.0% propylene glycol, 0.5-5.0% sodium dodecylnaphthalene sulfonate, 0.5-5.0% fatty alcohol polyoxyethylene ether, 0.5-5.0% sodium cocoyl imidazoline dicarboxylate, 0.5-5.0% propyl betaine, 0.05-5.0% disodium ethylenediaminetetraacetic acid, 0.01-1.0% flavor, and 39.0-91.94% deionized water. The invention uses biazyme, which has a high efficiency in degrading pesticides such as organophosphorus, as a pesticide residue removal and disinfection method for fruits, vegetables, and fabrics, which is highly efficient and non-toxic.

[0006] However, the composition for removing pesticide residues prepared by the above-mentioned invention patent has the defects of poor effect in removing residual pesticides, strong irritation to the skin, and easy residues on the surface of plants, causing secondary pollution, thereby affecting the health of consumers. In view of this, the art urgently needs to develop a cleaning composition that is excellent in removing residual pesticides in traditional Chinese medicine in the Fifteen Flavors Longdanhua Pills, and is mild and non-irritating. Summary of the invention

[0007] The invention aims at the problems existing in the prior art and provides a cleaning composition for removing pesticide residues in traditional Chinese medicine, a preparation method thereof and an application of the cleaning composition in preparing fifteen-flavor gentian flower pills.

[0008] To achieve the above purpose, the technical solution adopted by the present invention is as follows:

[0009] A cleaning composition for removing pesticide residues in traditional Chinese medicine comprises the following components: tea seeds, orange peels, loofah, citric acid, saponins, ginger, a surfactant, povidone K30 and water, wherein the surfactant is composed of disodium alcohol ether sulfosuccinate monoester, sophorolipids and dodecyltrimethylammonium chloride.

[0010] Preferably, the mass ratio of the alcohol ether sulfosuccinate monoester disodium salt, sophorolipid and dodecyltrimethylammonium chloride is 1-3:2-4:1-3.

[0011] Further preferably, the mass ratio of the alcohol ether sulfosuccinate monoester disodium salt, sophorolipid and dodecyltrimethylammonium chloride is 1-1.5:2-3:1-1.5.

[0012] More preferably, the mass ratio of the alcohol ether sulfosuccinate monoester disodium salt, sophorolipid and dodecyltrimethylammonium chloride is 1:2:1.

[0013] Preferably, the following components are included, by mass: 30-40 parts of tea seeds, 8-15 parts of orange peels, 7-10 parts of loofahs, 12-15 parts of citric acid, 4-8 parts of saponins, 3-6 parts of ginger, 15-20 parts of surfactants, 3-5 parts of povidone K30 and 60-80 parts of water.

[0014] Further preferably, the following components are included, by mass: 35-40 parts of tea seeds, 8-10 parts of orange peels, 8-10 parts of loofahs, 14-15 parts of citric acid, 6-8 parts of saponins, 4-6 parts of ginger, 18-20 parts of surfactants, 3-5 parts of povidone K30 and 70-80 parts of water.

[0015] More preferably, the following components are included, by mass: 40 parts of tea seeds, 8 parts of orange peels, 8 parts of loofahs, 15 parts of citric acid, 7 parts of saponins, 5 parts of ginger, 20 parts of surfactants, 4 parts of povidone K30 and 73 parts of water.

[0016] The present invention also provides a method for preparing the cleaning composition, comprising the following steps:

[0017] (1) First, citric acid, a surfactant, povidone K30 and water are mixed to obtain a solution;

[0018] (2) crushing tea seeds, orange peels, loofah, sapodilla and ginger, respectively extracting them with alcohol, and combining the alcohol extracts;

[0019] (3) Finally, the solution of step (1) and the alcohol extract of step (2) are mixed and concentrated to obtain.

[0020] Preferably, the mixing temperature in step (1) is 20-40° C., the mixing time is 15-20 min, and the pH needs to be adjusted to 7-8 after the mixing is completed.

[0021] Preferably, after the pulverization in step (2), the product is sieved through a 100-200 mesh sieve, and the alcohol extraction process includes adding 4-6 times the mass of a volume concentration of 70-80% ethanol solution, extracting at 60-70°C for 1-2h, filtering, and repeatedly extracting the filter residue 1-2 times, and combining the extracts.

[0022] Preferably, in step (3), the volume ratio of the solution to the extract is 5-8:2-3, the mixing requires stirring, the stirring speed is 500-800 rpm, the stirring time is 60-90 min, and after the concentration is completed, a viscous material with a relative density of 1-1.2 is obtained.

[0023] The present invention also provides a cleaning agent for removing pesticide residues, comprising the above cleaning composition or the cleaning composition prepared by the above preparation method.

[0024] The present invention also provides the use of the cleaning composition or the cleaning composition prepared by the preparation method or the cleaning agent in the preparation of fifteen-flavor gentian flower pills.

[0025] Compared with the prior art, the present invention has the following beneficial effects:

[0026] (1) The present invention obtains a cleaning composition for removing pesticide residues in traditional Chinese medicine by selecting a specific surfactant and based on the synergistic effect between disodium alcohol ether sulfosuccinate monoester, sophorolipids and dodecyltrimethylammonium chloride. The composition greatly improves the pesticide removal rate in traditional Chinese medicine in the Shiwuwei Longdanhua Pill and significantly reduces the pesticide residues in traditional Chinese medicine.

[0027] (2) The cleaning composition for removing pesticide residues in traditional Chinese medicine provided by the present invention, and its preparation method can significantly reduce the pesticide residues in the traditional Chinese medicine in the Fifteen Flavors Longdanhua Pills, have obvious technical advantages over conventional preparation processes, and the preparation method is simple, low-cost, and suitable for industrial production. DETAILED DESCRIPTION

[0028] It is worth noting that the raw materials used in the present invention are all common commercially available products, among which tea seeds, orange peels, loofahs, sapodillas and ginger are all provided by Ningxia Zhouyang Pharmaceutical Co., Ltd.

[0029] Example 1

[0030] A cleaning composition for removing pesticide residues in traditional Chinese medicine comprises the following components by weight: 40 parts of tea seeds, 8 parts of orange peels, 8 parts of loofahs, 15 parts of citric acid, 7 parts of sapodillas, 5 parts of ginger, 20 parts of surfactants, 4 parts of povidone K30 and 73 parts of water.

[0031] The surfactant consists of disodium alcohol ether sulfosuccinate monoester, sophorolipids and dodecyltrimethylammonium chloride in a mass ratio of 1:2:1.

[0032] The preparation method of the cleaning composition for removing pesticide residues in traditional Chinese medicine is as follows:

[0033] (1) First, citric acid, surfactant, povidone K30 and water were stirred and mixed at 30° C. for 20 min at a stirring speed of 400 rpm, and the pH was adjusted to obtain a solution with a pH of 7;

[0034] (2) Crush the tea seeds, orange peel, loofah, sapodilla and ginger, and pass through a 200-mesh sieve. Add 5 times the mass of 75% ethanol solution to the tea seed powder, orange peel powder, loofah powder, sapodilla powder and ginger powder, respectively, extract at 65° C. for 2 h, filter, repeat extraction twice with the residue, and combine the extracts. Combine the tea seed extract, orange peel extract, loofah extract, sapodilla extract and ginger extract to obtain a combined alcohol extract;

[0035] (3) Finally, the pH=7 solution of step (1) and the combined alcohol extract of step (2) were stirred at 600 rpm in a volume ratio of 3:1 for 60 min, and then concentrated under reduced pressure to obtain a viscous substance with a relative density of 1-1.2.

[0036] Example 2

[0037] A cleaning composition for removing pesticide residues in traditional Chinese medicines comprises the following components, measured by mass: 35 parts of tea seeds, 10 parts of orange peels, 8 parts of loofahs, 14 parts of citric acid, 8 parts of sapodillas, 6 parts of ginger, 18 parts of surfactants, 5 parts of povidone K30 and 80 parts of water.

[0038] The surfactant consists of disodium alcohol ether sulfosuccinate monoester, sophorolipid and dodecyltrimethylammonium chloride in a mass ratio of 1.5:2:1.

[0039] The preparation method of the cleaning composition for removing pesticide residues in traditional Chinese medicine is as follows:

[0040] (1) First, citric acid, surfactant, povidone K30 and water were stirred and mixed at 40° C. for 15 min at a stirring speed of 400 rpm, and the pH was adjusted to obtain a solution with a pH of 7;

[0041] (2) Crush the tea seeds, orange peel, loofah, sapodilla and ginger, and pass through a 150-mesh sieve. Add 4 times the mass of 80% ethanol solution by volume to the tea seed powder, orange peel powder, loofah powder, sapodilla powder and ginger powder, respectively, extract at 70° C. for 2 h, filter, repeat extraction twice on the residue, and combine the extracts. Combine the tea seed extract, orange peel extract, loofah extract, sapodilla extract and ginger extract to obtain a combined alcohol extract;

[0042] (3) Finally, the pH=7 solution of step (1) and the combined alcohol extract of step (2) were stirred at 800 rpm in a volume ratio of 5:2 for 90 minutes, and then concentrated under reduced pressure to obtain a viscous substance with a relative density of 1-1.2.

[0043] Example 3

[0044] A cleaning composition for removing pesticide residues in traditional Chinese medicine comprises the following components by weight: 30 parts of tea seeds, 15 parts of orange peels, 7 parts of loofahs, 12 parts of citric acid, 4 parts of sapodillas, 3 parts of ginger, 15 parts of surfactants, 3 parts of povidone K30 and 70 parts of water.

[0045] The surfactant consists of disodium alcohol ether sulfosuccinate monoester, sophorolipids and dodecyltrimethylammonium chloride in a mass ratio of 3:4:3.

[0046] The preparation method of the cleaning composition for removing pesticide residues in traditional Chinese medicine is as follows:

[0047] (1) First, citric acid, surfactant, povidone K30 and water were stirred and mixed at 20° C. for 20 min at a stirring speed of 400 rpm, and the pH was adjusted to obtain a solution with a pH of 7.5;

[0048] (2) Crush the tea seeds, orange peel, loofah, sapodilla and ginger, and pass through a 100-mesh sieve. Add 6 times the mass of a 70% ethanol solution to the tea seed powder, orange peel powder, loofah powder, sapodilla powder and ginger powder, respectively, extract at 60° C. for 1 h, filter, and extract the residue twice, and combine the extracts. Combine the tea seed extract, orange peel extract, loofah extract, sapodilla extract and ginger extract to obtain a combined alcohol extract;

[0049] (3) Finally, the pH 7.5 solution of step (1) and the combined alcohol extract of step (2) were stirred at 500 rpm in a volume ratio of 8:3 for 80 min, and then concentrated under reduced pressure to obtain a viscous substance with a relative density of 1-1.2.

[0050] Comparative Example 1

[0051] The same as Example 1, the only difference is that the surfactant is composed of disodium alcohol ether sulfosuccinate monoester and dodecyltrimethylammonium chloride in a mass ratio of 1:1.

[0052] A cleaning composition for removing pesticide residues in traditional Chinese medicine comprises the following components by weight: 40 parts of tea seeds, 8 parts of orange peels, 8 parts of loofahs, 15 parts of citric acid, 7 parts of sapodillas, 5 parts of ginger, 20 parts of surfactants, 4 parts of povidone K30 and 73 parts of water.

[0053] The surfactant consists of disodium alcohol ether sulfosuccinate monoester and dodecyltrimethylammonium chloride in a mass ratio of 1:1.

[0054] The preparation method of the cleaning composition for removing pesticide residues in traditional Chinese medicine is the same as that in Example 1.

[0055] Comparative Example 2

[0056] The same as Example 1, the only difference is that the surfactant is sophorolipid.

[0057] A cleaning composition for removing pesticide residues in traditional Chinese medicine comprises the following components by weight: 40 parts of tea seeds, 8 parts of orange peels, 8 parts of loofahs, 15 parts of citric acid, 7 parts of sapodillas, 5 parts of ginger, 20 parts of surfactants, 4 parts of povidone K30 and 73 parts of water.

[0058] The surfactant is sophorolipid.

[0059] The preparation method of the cleaning composition for removing pesticide residues in traditional Chinese medicine is the same as that in Example 1.

[0060] Comparative Example 3

[0061] The same as Example 1, except that the surfactant consists of sophorolipids and dodecyltrimethylammonium chloride in a mass ratio of 1:1.

[0062] A cleaning composition for removing pesticide residues in traditional Chinese medicine comprises the following components by weight: 40 parts of tea seeds, 8 parts of orange peels, 8 parts of loofahs, 15 parts of citric acid, 7 parts of sapodillas, 5 parts of ginger, 20 parts of surfactants, 4 parts of povidone K30 and 73 parts of water.

[0063] The surfactant consists of sophorolipids and dodecyltrimethylammonium chloride in a mass ratio of 1:1.

[0064] The preparation method of the cleaning composition for removing pesticide residues in traditional Chinese medicine is the same as that in Example 1.

[0065] Comparative Example 4

[0066] The same as Example 1, the only difference is that the surfactant is composed of alcohol ether sulfosuccinic acid monoester disodium salt and sophorolipids in a mass ratio of 1:1.

[0067] A cleaning composition for removing pesticide residues in traditional Chinese medicine comprises the following components by weight: 40 parts of tea seeds, 8 parts of orange peels, 8 parts of loofahs, 15 parts of citric acid, 7 parts of sapodillas, 5 parts of ginger, 20 parts of surfactants, 4 parts of povidone K30 and 73 parts of water.

[0068] The surfactant consists of alcohol ether sulfosuccinic acid monoester disodium salt and sophorolipid in a mass ratio of 1:1.

[0069] The preparation method of the cleaning composition for removing pesticide residues in traditional Chinese medicine is the same as that in Example 1.

[0070] Comparative Example 5

[0071] The same as Example 1, the only difference is that the components do not contain povidone K30.

[0072] A cleaning composition for removing pesticide residues in traditional Chinese medicines comprises the following components by weight: 40 parts of tea seeds, 8 parts of orange peels, 8 parts of loofahs, 15 parts of citric acid, 7 parts of sapodillas, 5 parts of ginger, 20 parts of surfactants and 77 parts of water.

[0073] The surfactant consists of disodium alcohol ether sulfosuccinate monoester, sophorolipids and dodecyltrimethylammonium chloride in a mass ratio of 1:2:1.

[0074] The preparation method of the cleaning composition for removing pesticide residues in traditional Chinese medicine is the same as that in Example 1.

[0075] Comparative Example 6

[0076] The same as Example 1, the only difference is the number of components.

[0077] A cleaning composition for removing pesticide residues in traditional Chinese medicine comprises the following components by weight: 50 parts of tea seeds, 20 parts of orange peels, 6 parts of loofahs, 8 parts of citric acid, 7 parts of sapodillas, 6 parts of ginger, 5 parts of surfactants, 4 parts of povidone K30 and 80 parts of water.

[0078] The surfactant consists of disodium alcohol ether sulfosuccinate monoester, sophorolipids and dodecyltrimethylammonium chloride in a mass ratio of 1:2:1.

[0079] The preparation method of the cleaning composition for removing pesticide residues in traditional Chinese medicine is the same as that in Example 1.

[0080] Comparative Example 7

[0081] The same as Example 1, the only difference is that the volume concentration of the ethanol solution in step (2) is 60%.

[0082] A cleaning composition for removing pesticide residues in traditional Chinese medicine comprises the following components by weight: 40 parts of tea seeds, 8 parts of orange peels, 8 parts of loofahs, 15 parts of citric acid, 7 parts of sapodillas, 5 parts of ginger, 20 parts of surfactants, 4 parts of povidone K30 and 73 parts of water.

[0083] The surfactant consists of disodium alcohol ether sulfosuccinate monoester, sophorolipids and dodecyltrimethylammonium chloride in a mass ratio of 1:2:1.

[0084] The preparation method of the cleaning composition for removing pesticide residues in traditional Chinese medicine is as follows:

[0085] (1) First, citric acid, surfactant, povidone K30 and water were stirred and mixed at 30° C. for 20 min at a stirring speed of 400 rpm, and the pH was adjusted to obtain a solution with a pH of 7;

[0086] (2) Crush the tea seeds, orange peel, loofah, sapodilla and ginger, and pass through a 200-mesh sieve. Add 5 times the mass of a 60% ethanol solution to the tea seed powder, orange peel powder, loofah powder, sapodilla powder and ginger powder, respectively, extract at 65° C. for 2 h, filter, and extract the residue twice, and combine the extracts. Combine the tea seed extract, orange peel extract, loofah extract, sapodilla extract and ginger extract to obtain a combined alcohol extract;

[0087] (3) Finally, the pH=7 solution of step (1) and the combined alcohol extract of step (2) were stirred at 600 rpm in a volume ratio of 3:1 for 60 min, and then concentrated under reduced pressure to obtain a viscous substance with a relative density of 1-1.2.

[0088] Test Case

[0089] The Chinese medicinal materials in the Shiwuwei Longdanhua Pills include white gentian, wide tendon vine and liquorice, and the pesticides to be tested include organochlorine pesticides (total DDT and aldrin) and organophosphorus pesticides (methyl parathion).

[0090] Preparation of cleaning agent: The cleaning compositions for removing pesticide residues in traditional Chinese medicine prepared in Examples 1-3 and Comparative Examples 1-7 were respectively mixed with water at a mass ratio of 1:1000 to obtain cleaning agents.

[0091] Sample preparation: Weigh 100g of Gentiana alba, Caulis gentiana and Glycyrrhiza uralensis respectively, and then spray them with 100ml of 5μg / mL total DDT, aldrin and methamidophos standard solutions respectively, until the surface is wet, and leave it for 24h for use.

[0092] Experimental method: Soak the samples in the above-mentioned cleaning agent for 15 minutes, take them out and rinse them with running water for 30 seconds, and dry them naturally as the treated group; the samples without cleaning were used as the untreated group, and the pesticide concentration of the Chinese medicinal materials in the treated and untreated groups was tested. The test basis was the pesticide residue determination method 2341 in the general rules of Part IV of the 2020 edition of the "Chinese Pharmacopoeia", and the pesticide removal rate was calculated.

[0093] The calculation formula for pesticide removal rate is:

[0094] Pesticide removal rate (%) = (pesticide concentration in untreated group - pesticide concentration in treated group) / pesticide concentration in untreated group × 100% The pesticide removal rates of the cleaning agents prepared in Examples 1-3 and Comparative Examples 1-7 after cleaning the Chinese medicinal materials are shown in Table 1.

[0095] Table 1 Pesticide removal rate of the cleaning agents of Examples 1-3 and Comparative Examples 1-7 on Chinese medicinal materials (%)

[0096]

[0097]

[0098] Note: Compared with Example 1, * indicates P < 0.05, ** Indicates P<0.01.

[0099] As can be seen from Table 1, the cleaning compositions for removing pesticide residues in traditional Chinese medicine prepared in Examples 1-3 are better than Comparative Examples 1-7, and the cleaning compositions of the present invention significantly reduce the pesticide residues in the fifteen-flavor gentian flower pills. As can be seen from Example 1 and Comparative Examples 1-4, according to the synergistic effect of alcohol ether sulfosuccinic acid monoester disodium salt, sophorolipids and dodecyltrimethylammonium chloride, a cleaning composition for removing pesticide residues in traditional Chinese medicine is obtained, and the composition significantly improves the pesticide removal rate in traditional Chinese medicine in the fifteen-flavor gentian flower pills. As can be seen from Example 1 and Comparative Examples 5 and 6, only the specific composition formula of the present invention can significantly improve the pesticide removal rate in traditional Chinese medicine in the fifteen-flavor gentian flower pills. As can be seen from Example 1 and Comparative Example 7, the cleaning composition for removing pesticide residues in traditional Chinese medicine provided by the present invention, and its preparation method can significantly reduce the pesticide residues in traditional Chinese medicine in the fifteen-flavor gentian flower pills, and the preparation method is simple, low cost, and suitable for industrial production.

[0100] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions of the technical solution of the present invention by ordinary technicians in this field do not deviate from the essence and scope of the technical solution of the present invention.

Claims

1. A cleaning composition for removing pesticide residues in traditional Chinese medicine, characterized in that: The invention comprises the following components: tea seeds, orange peels, loofah, citric acid, sapodilla, ginger, a surfactant, povidone K30 and water. The surfactant is composed of disodium alcohol ether sulfosuccinate monoester, sophorolipids and dodecyltrimethylammonium chloride.

2. The cleaning composition according to claim 1, characterized in that The mass ratio of the alcohol ether sulfosuccinate monoester disodium salt, sophorolipid and dodecyltrimethylammonium chloride is 1-3:2-4:1-3.

3. The cleaning composition according to claim 2, characterized in that The mass ratio of the alcohol ether sulfosuccinate monoester disodium salt, sophorolipid and dodecyltrimethylammonium chloride is 1-1.5:2-3:1-1.

5.

4. The cleaning composition according to claim 1, characterized in that The invention comprises the following components by weight: 30-40 parts of tea seeds, 8-15 parts of orange peels, 7-10 parts of loofahs, 12-15 parts of citric acid, 4-8 parts of saponins, 3-6 parts of ginger, 15-20 parts of surfactants, 3-5 parts of povidone K30 and 60-80 parts of water.

5. A method for preparing the cleaning composition according to any one of claims 1 to 4, characterized in that: The steps include: (1) First, citric acid, a surfactant, povidone K30 and water are mixed to obtain a solution; (2) crushing tea seeds, orange peels, loofah, sapodilla and ginger, respectively extracting them with alcohol, and combining the alcohol extracts; (3) Finally, the solution of step (1) and the alcohol extract of step (2) are mixed and concentrated to obtain.

6. The preparation method according to claim 5, characterized in that: The mixing temperature in step (1) is 20-40° C., the mixing time is 15-20 min, and the pH needs to be adjusted to 7-8 after the mixing is completed.

7. The preparation method according to claim 5, characterized in that: After the pulverization in step (2) is completed, the mixture is sieved through a 100-200 mesh sieve. The alcohol extraction process includes adding 4-6 times the mass of a volume concentration of 70-80% ethanol solution, extracting at 60-70° C. for 1-2 hours, filtering, and repeatedly extracting the residue 1-2 times, and combining the extracts.

8. The preparation method according to claim 5, characterized in that: In step (3), the volume ratio of the solution to the extract is 5-8:2-3, the mixing requires stirring, the stirring speed is 500-800 rpm, the stirring time is 60-90 min, and after the concentration is completed, a viscous material with a relative density of 1-1.2 is obtained.

9. A cleaning agent for removing pesticide residues, characterized in that: The invention comprises the cleaning composition according to any one of claims 1 to 4 or the cleaning composition prepared by the preparation method according to any one of claims 5 to 8.

10. Use of the cleaning composition according to any one of claims 1 to 4 or the cleaning composition prepared by the preparation method according to any one of claims 5 to 8 or the cleaning agent according to claim 9 in the preparation of Shiwuwei Longdanhua Pills.

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