A microbubble generating component and device

Abstract

The present invention relates to a microbubble generating component and device, comprising: a first connector and a second connector; a syringe connector is arranged at one end of the first connector, and a first connecting section connected to the second connector is arranged at the other end, the first connecting section is composed of a first straight section and a first contraction section; the second connector comprises a second connecting section and a venturi tube, and a gap cavity is arranged between the first contraction section and the third contraction section of the venturi tube; a plurality of air inlet channels connected to the gap cavity are opened on the side wall of the second connecting section; an independent fluid and gas mixing structure is adopted, and Bernoulli principle is used for acceleration to reduce the static pressure of the fluid, and the gap cavity between the first contraction section and the venturi tube is coordinated so that when the accelerated liquid enters the fluid channel of the second connector, more gas in the gap cavity is brought into the liquid, and the bubbles in the liquid can be sheared through the venturi tube structure to reduce the volume of the bubbles and increase the number of the bubbles.

Description

Technical Field

[0001] The invention belongs to the technical field of medical devices, and in particular relates to a microbubble generating component and a microbubble generating device using the component. Background Art

[0002] Patent foramen ovale is a congenital heart disease, which means that the oval foramen of the left and right atria fail to close completely during the development of infants, resulting in an abnormal channel between the left and right atria. PFO exists in 1 / 4 of the general population and is related to various diseases, especially migraine and cryptogenic stroke.

[0003] At present, patent foramen ovale is usually diagnosed by transthoracic echocardiography or transcranial Doppler ultrasound angiography. Among them, right heart system ultrasound angiography is an ultrasound diagnostic technique widely used in the clinical diagnosis and treatment of PFO, and ultrasound contrast agents (microbubbles) are often used in the process. Microbubbles are injected through the vein and reach the right atrium with the blood circulation. When PFO is present, microbubbles will enter the left atrium, left ventricle, aorta and intracranial arteries through the unclosed foramen ovale. These microbubbles will strongly reflect ultrasound and can be detected by the probe of echocardiography or transcranial Doppler to confirm the presence and size of PFO.

[0004] In the prior art, the production of ultrasound contrast agents for diagnosing PFO mainly relies on the manual oscillation method, that is, by manually pushing the saline in two syringes connected to the three-way tube back and forth 15-20 times to fully mix the saline and gas. This method has the following disadvantages: First, it is time-consuming and labor-intensive. Each patient usually needs 3 contrast studies. The production of each subject's contrast study takes at least 3-5 minutes. If contrast studies are performed on multiple patients in succession, it usually takes dozens of minutes to produce the contrast study. Second, inexperienced operators have a slow injection speed or different injection times, resulting in poor mixing effects. Therefore, there is an urgent need for a microbubble generating structure that is small in size and efficient in producing microbubbles. Summary of the invention

[0005] In view of this, the present invention provides a microbubble generating component, which adopts an independent fluid and gas mixing structure, and applies the structure to a fluid channel. By using the Bernoulli principle, when the static pressure of the fluid decreases, more gas is mixed into the fluid by using the force of the pressure potential difference, so as to achieve the effect of mixing more bubbles into the contrast agent. After the gas-liquid mixture passes through the Venturi tube, the gas phase will be squeezed into smaller bubbles in the diffusion section due to the increase in static pressure. At the same time, the bubble volume will be further reduced by the shearing action of turbulence, thereby achieving rapid bubble generation.

[0006] The technical solution adopted by the present invention is:

[0007] A microbubble generating assembly comprises: a first connector and a second connector respectively provided with fluid channels; a syringe connector is provided at one end of the first connector, and a first connecting section connected to the second connector is provided at the other end, the first connecting section is composed of a first straight section and a first contraction section; the second connector comprises an integrally formed second connecting section and a venturi tube, the first connecting section is connected to the second connector through the second connecting section, and a gap cavity is provided between the first contraction section and the third contraction section of the venturi tube; a needle connector for connecting an injection needle is provided at one end of the venturi tube away from the second connecting section; a plurality of air inlet channels connected to the gap cavity are provided on the side wall of the second connecting section, and the air inlet channels are communicated with a sterile air chamber.

[0008] Further optimization of the technical solution of the present invention, the second connecting section is composed of a second straight section and a second contraction section, the second contraction section is a frustoconical contraction section, the inner diameter of the end of which is smaller than the maximum inner diameter of the third contraction section, the inner diameter of the second straight section is equal to the outer diameter of the first straight section, the inner diameter of the second contraction section is equal to the outer diameter of the corresponding part of the first contraction section, and the gap cavity is composed of the inner diameter of the third contraction section and the outer diameter of the first contraction section.

[0009] According to a further optimization of the technical solution of the present invention, a first straight hole is provided at the end of the inner wall of the first contraction section, the Venturi tube comprises a third contraction section, a third straight section and an expansion section, the first straight hole is gap-connected with the third straight section, and the diameter of the first straight hole is smaller than the inner diameter of the third straight section.

[0010] Further optimization of the technical solution of the present invention also includes a third connector, which is respectively connected to the side wall of the first connector and the end of the second connector away from the second connecting section, and the third connector is provided with a sterile air chamber connected to the air inlet channel, and the first connector is provided with a first through hole connected to the sterile air chamber; in this embodiment, the needle connector is arranged on the outlet of the third connector.

[0011] According to further optimization of the technical solution of the present invention, a first step groove is provided on the inner wall of one end of the third connector, a sealing platform matching the first step groove is provided on the first connector, a sealing groove for placing an O-ring is provided on the sealing platform, and the first through hole is provided between the sealing platform and the first connecting section.

[0012] Further optimization of the technical solution of the present invention is that an annular platform is arranged between the first through hole and the first connecting section, and the annular platform divides the sterile air chamber into a first air chamber and a second air chamber that are connected to each other, and the first through hole is directly connected to the first air chamber; the gap cavity is connected to the second air chamber through the air inlet channel, and the connection between the first air chamber and the second air chamber is far away from the air inlet channel.

[0013] Further optimization of the technical solution of the present invention, the second connecting body also includes a third connecting section, the third connecting section is connected to the expansion section of the venturi tube, and the outer side wall of the third connecting section is a conical side wall, and a second step groove matching the third connecting section is provided in the third connecting body, and the second step groove is sealed and connected to the third connecting section.

[0014] According to a further optimization of the technical solution of the present invention, a second through hole is provided on the third connecting section or on the fluid passage of the third connecting body.

[0015] According to a further optimization of the technical solution of the present invention, a plurality of Venturi structures are provided on the fluid channel between the second step groove and the needle connector, and a second through hole is provided on the throat of the Venturi structure and / or the flat fluid channel connected to the expansion section.

[0016] In a further optimization of the technical solution of the present invention, a microporous structure for breaking up bubbles is provided on the fluid channel downstream of the venturi tube.

[0017] The present invention also provides a microbubble generating device, comprising: a syringe, an injection needle and the microbubble generating assembly described above, wherein the syringe is connected to the first connector, and the injection needle is connected to the end of the second connector or the third connector.

[0018] Beneficial effects of the present invention:

[0019] By arranging the first contraction section on the first connecting body, the Bernoulli principle can be used to accelerate the liquid in the fluid channel during injection, so that the static pressure of the fluid is reduced, and the gap cavity between the first contraction section and the venturi tube is cooperated so that when the accelerated liquid enters the fluid channel of the second connecting body, more gas in the gap cavity is brought into the liquid, and through the re-compression and diffusion of the venturi tube, the bubbles in the liquid can be sheared, so that the volume of the bubbles becomes smaller and the number increases, thereby producing a liquid that meets the requirements of a large number of microbubbles and a small volume.

[0020] By providing a third connector and opening a first through hole on the first connector, and combining the sterile air chamber, when the component is working, part of the liquid in the fluid channel enters the sterile air chamber through the first through hole, thereby increasing the air pressure in the sterile air chamber. By utilizing the pressure potential difference, the liquid flowing through the fluid channel is mixed with more gas through the gap cavity, thereby increasing the amount of gas mixed, and generating more and smaller microbubbles in the liquid. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] The above and other objects, features and advantages of the present invention will become more apparent through the following description of the embodiments of the present invention with reference to the accompanying drawings, in which:

[0022] Figure 1 is a schematic structural diagram of the first connector of the present invention;

[0023] Figure 2 is a cross-sectional view of a first connector of the present invention;

[0024] Figure 3 It is a schematic structural diagram of the second connector A and B of the present invention from two viewing angles;

[0025] Figure 4 is a cross-sectional view of a second connector of the present invention;

[0026] Figure 5 is a schematic structural diagram of the third connector of the present invention;

[0027] Figure 6 is a schematic cross-sectional structure diagram of a third connector of the present invention;

[0028] Figure 7 Schematic diagram of the overall cross-sectional structure of the microbubble generating assembly of the present invention;

[0029] Figure 8 yes Figure 7 A schematic diagram of the local enlarged structure of position 1-2;

[0030] Fig. 9 It is a schematic diagram of the overall cross-sectional structure of a preferred embodiment of the microbubble generating assembly of the present invention.

[0031] In the figure: 1, first connector; 2, second connector; 3, third connector; 5, fluid channel; 6, Venturi structure;

[0032] 11. syringe connector; 12. first connecting section; 121. first straight section; 122. first contraction section; 123. first straight hole; 13. gap cavity; 15. annular platform; 16. sealing platform; 17. sealing groove; 18. first through hole;

[0033] 21. second connecting section; 211. second straight section; 212. second contraction section; 22. third connecting section; 23. third contraction section; 24. third straight section; 25. expansion section; 26. air inlet passage;

[0034] 31. needle connector; 32. first step groove; 33. second step groove; 34. sterile air chamber; 341. first air chamber; 342. second air chamber; 35. third mounting column. DETAILED DESCRIPTION

[0035] The present invention is described below based on embodiments, but the present invention is not limited to these embodiments. In the following detailed description of the present invention, some specific details are described in detail. In order to avoid confusing the essence of the present invention, known methods, processes, procedures, and components are not described in detail.

[0036] In addition, persons of ordinary skill in the art will appreciate that the drawings provided herein are for illustration purposes and are not necessarily drawn to scale.

[0037] Unless the context clearly requires otherwise, throughout the specification and claims, the words "include", "comprising" and similar words should be interpreted in an inclusive sense rather than an exclusive or exhaustive sense; that is, in the sense of "including but not limited to".

[0038] In the description of the present invention, it should be understood that the terms "first", "second", etc. are only used for descriptive purposes and cannot be understood as indicating or implying relative importance. In addition, in the description of the present invention, unless otherwise specified, "plurality" means two or more.

[0039] See also Figure 1-Figure 9 The present invention provides a microbubble generating assembly, comprising: a first connector 1 and a second connector 2, each of which has a fluid channel 5; Figure 1 and Figure 2 As shown, a syringe connector 11 is provided at one end of the first connector 1, and liquid can be injected into the fluid channel 5 connected to the first connector 1 and the second connector 2 through a syringe when in use. A first connecting section 12 connected to the second connector 2 is provided at the other end of the first connector 1, and the first connecting section 12 is composed of a first straight section 121 and a first contraction section 122. The first contraction section 122 is a conical structure with a gradually contracting inner diameter, and the aperture of the cone tip is preferably 0.3-0.35mm. The contraction section can accelerate the liquid that initially enters the fluid channel 5, reduce the static pressure in the fluid, and then transport the accelerated liquid to the second connector 2; as shown Figure 3 and Figure 4As shown, the second connector 2 includes an integrally formed second connecting section 21 and a venturi tube, the first connecting section 12 is connected to the second connector 2 through the second connecting section 21 to increase the stability of the microbubble generating assembly, and the other end of the second connector 2 is provided with a needle connector 31 for outputting the gas-liquid mixed phase; the first contraction section 122 cooperates with the third contraction section 23 of the venturi tube, wherein the taper in the first contraction section 122 and the third contraction section 23 has no strict requirement, and is preferably 60 degrees. A gap cavity 13 is arranged between the outer wall of the first contraction section 122 and the inner wall of the third contraction section 23, and a plurality of air inlet channels 26 connected to the gap cavity 13 are arranged on the side wall of the second connecting section 21. Preferably, the width of the air inlet channel 26 is 1-3 mm, and it is mainly used to continuously supply gas to the gap cavity 13; the air inlet channel 26 is connected to the sterile air chamber, and the sterile air chamber can be externally connected or arranged on the second connector 2; preferably, the pressure in the sterile air chamber is greater than the atmospheric pressure (an external constant pressure device can be selected), and can be 1.03-1.25 atmospheres. This design is mainly to enable the gas in the sterile air chamber to actively enter the liquid. Of course, it can also be in a normal pressure state, because there is a negative pressure in the gap cavity 13, and the gas will automatically enter the liquid. When the liquid flows from the first connector 1 to the second connector 2, the gas in the gap cavity 13 can be brought into the liquid and enter the venturi tube, and when the fluid flows through the first contraction section 122 and enters the third straight section 24 of the venturi tube, the flow rate increases and the static pressure decreases; when it flows into the expansion section 25 of the venturi tube for diffusion, the flow rate decreases, the static pressure increases, and turbulence is formed. At this time, the gas phase in the gas-liquid mixed phase will be squeezed into smaller bubbles due to the increase in static pressure, and at the same time, the bubble volume will be further reduced by the shearing action of the turbulent flow, forming a larger number of microbubbles. The expansion section 25 of the venturi tube is a conical diffusion shape, and its taper is preferably 15-50 degrees.

[0040] In the present technical solution, the second connecting section 21 is composed of a second straight section 211 and a second contraction section 212. The second contraction section 212 is a cone-shaped contraction section. From the large end face to the small end face, the inner diameter of the small end face is smaller than the inner diameter of the large end face of the third contraction section 23, so that a step is formed between the second contraction section 212 and the third contraction section 23. The inner diameter of the second straight section 211 is equal to the outer diameter of the first straight section 121, which is more stable when the first connector 1 is connected to the second connector 2. The inner diameter of the second contraction section 212 is equal to the outer diameter of the corresponding part of the first contraction section 122. Since the length of the cone of the second contraction section 212 is smaller than the length of the cone of the first contraction section 122, the first contraction section 122 enters the third contraction section 23 after passing through the second contraction section 212, so that the gap cavity 13 is formed between the outer side surface of the first contraction section 122 and the inner side surface of the third contraction section 23. For details, please refer to Figure 8The structure shown.

[0041] In order to increase the stability of the fluid, a first straight hole 123 is provided at the end of the inner wall of the first contraction section 122. The length of the first straight hole 123 is preferably 0.5-1.5 mm, and the aperture is 0.3-0.35 mm. It should be noted here that the outer wall of the first contraction section 122 does not have a straight section, and the outer wall is a cone surface. The first straight hole 123 is gap-connected with the third straight section 24, and the diameter of the first straight hole 123 is smaller than the inner diameter of the third straight section 24. Preferably, the inner diameter of the third straight section 24 is 0.05-0.1 mm larger than the diameter of the first straight hole 123. In this way, the smoothness of the fluid entering the third straight section 24 of the venturi tube from the first contraction section 122 can be improved. At the same time, the diffusion effect after the high-speed fluid flows out and the pressure difference between the static pressure of the fluid and the gas in the built-up cavity can be used to mix the liquid phase with more gas phase in the gap cavity 13.

[0042] On the basis of the above technical solution, the best implementation method of the technical solution of this application also includes: Figure 5 and Figure 6 The third connector 3 shown in the figure is respectively connected to the side wall of the first connector 1 and the end of the second connector 2 away from the second connecting section 21. Specifically, the front section of the third connector 3 is a cavity structure, and the inner wall of the free end of the cavity is provided with a first step groove 32, such as Figure 7 As shown, the first connector 1 and the second connector 2 are connected and installed in the cavity of the third connector 3. The first connector 1 is provided with a sealing platform 16 that matches the first step groove 32. The first step groove 32 and the sealing platform 16 make the first connector 1 and the third connector 3 sealed and connected. The structure can be a thread and a sealing gasket, or a clamping connection. In order to improve the sealing between the first connector 1 and the third connector 3, preferably, the sealing platform 16 is provided with a sealing groove 17 for placing an O-ring. The third connector 3 is provided with a sterile air chamber 34 connected to the air inlet channel 26. Specifically, the sterile air chamber 34 is composed of the side walls of the first connecting section 12 and the side walls of the second connector 2 and the inner walls of the cavity of the third connector 3 respectively, and the first connector 1 is provided with a first through hole 18 connected to the sterile air chamber 34. Preferably, the first through hole 18 is opened between the sealing platform 16 and the first connecting section 12, and the number of the first through hole 18 can be 1, 2 or more, and the diameter of the first through hole 18 is 0.15mm-0.35mm; the other end of the third connector 3 is provided with a needle connector 31 for connecting an injection needle.

[0043] In order to improve the mixing degree of liquid and gas, an annular platform 15 is provided on the first connector 1 between the first through hole 18 and the first connecting section 12, and the annular platform 15 divides the sterile gas chamber 34 into a first gas chamber 341 and a second gas chamber 342 that are connected. The first through hole 18 is directly connected to the first gas chamber 341; the gap cavity 13 is connected to the second gas chamber 342 through the air inlet channel 26, and the connection between the first gas chamber 341 and the second gas chamber 342 is far away from the air inlet channel 26. Since the first through hole 18 is located upstream of the air inlet channel 26, when the liquid enters the fluid channel 5 under the push of the syringe, under the action of the first contraction section 122, part of the liquid will enter the sterile gas chamber 34 through the first through hole 18, thereby increasing the pressure of the sterile gas chamber 34 and promoting the gas to enter the gap cavity 13 and mix with the liquid. By providing the annular platform 15, the first through hole 18 and the air inlet channel 26 can be separated. The function of making the connection between the first air chamber 341 and the second air chamber 342 away from the air inlet channel 26 is: when the liquid flowing out of the first through hole 18 flows into the second air chamber 342 through the connection, the liquid flowing out of the first through hole 18 does not contact the air inlet of the air inlet channel 26, thereby avoiding the liquid from flowing into the gap cavity and affecting the mixing of gas and liquid. The connection between the first air chamber 341 and the second air chamber 342 can be the gap between the annular platform 15 and the inner wall of the third connector 3, or it can be set as a separate connecting hole. In the process of practical application, the microbubble generating assembly is mostly in a vertical state, so that the liquid flowing out of the first through hole 18 will enter the bottom of the second air chamber 342 from the first air chamber 341 through the connection under the action of gravity, so that the gas in the entire sterile air chamber 34 will be compressed, the pressure will increase, and the air pressure in the gap cavity connected thereto will also increase, thereby forming a pressure difference between the gap cavity and the fluid, which is conducive to the gas entering the liquid.

[0044] On the basis of the third connector 3, the second connector 2 further includes a third connecting section 22, and the third connecting section 22 is connected to the expansion section 25 of the venturi tube, that is, the fluid channel 5 of the expansion section 25 of the venturi tube continues to extend to form the third connecting section 22. In order to facilitate the connection and sealing between the third connecting section 22 and the third connector 3, the outer side wall of the third connecting section 22 is a tapered side wall, and the third connector 3 is provided with a second step groove 33 matching the third connecting section 22, and the inner side wall of the second step groove 33 is also provided with an inclination corresponding to the third connecting section 22, so that the second step groove 33 is conveniently sealed and connected with the third connecting section 22. Preferably, the third connector 3 includes a tubular housing connected to the first connector 1 and the second connector 2, and a third mounting column 35 connected to the second connector 2 is arranged inside the tubular housing, one end of the third mounting column 35 is adjacent to the needle connector 31 of the injection needle, and the second step groove 33 is arranged on the fluid channel 5 at the other end, and a gap is left between the side wall of the third mounting column 35 and the shell, and the gap constitutes a part of the second air chamber 342. This design is mainly to facilitate the connection between the second connector 2 and the third connector 3. As an alternative technical solution, the third connecting section 22 and the third mounting column 35 can also be connected by threaded sealing, or by snap-fitting and sealing ring.

[0045] A preferred implementation manner of the present technical solution is to better mix more gas into the liquid in the fluid channel 5, a second through hole is opened on the third connecting section 22 or the fluid channel 5 of the third connecting body 3, and the second through hole is connected to the second air chamber 342. When working, the gas in the second air chamber 342 can also enter the fluid channel 5 through the second through hole to mix with the flowing liquid, thereby increasing the mixing amount of the gas phase in the liquid phase. Preferably, the diameter of the second through hole is between 0.1mm and 0.2mm.

[0046] Another preferred implementation of this technical solution is as follows Fig. 9As shown, a plurality of Venturi structures 6 are arranged on the fluid channel 5 between the second step groove 33 and the needle connector 31, and the tapers of the contraction section and the expansion section 25 of all the Venturi structures 6 can be kept consistent, but the diameter of the middle throat increases successively from upstream to downstream, and preferably the throat diameters of two adjacent Venturi structures 6 differ by 0.05mm-0.1mm. Through the contraction section, the straight throat section and the expansion section 25 of the Venturi structure 6, the mixed phase of the gas phase and the liquid phase can be compressed and turbulent, so that the gas phase in the liquid phase becomes smaller, and a second through hole is opened in the throat of the Venturi structure 6 or / and the straight fluid channel 5 connected to the expansion section 25, and the second through hole is connected to the sterile air chamber 34, so that the liquid phase in the fluid channel 5 can be mixed with more gas phase during operation, and in conjunction with the working principle of the Venturi structure, the gas phase can be cut into more and smaller microbubbles, and the working principle of the second through hole is the same as the first through hole 18.

[0047] In order to increase the number of bubbles while reducing the volume of the bubbles, preferably, a microporous structure for splitting the bubbles is provided on the fluid channel 5 downstream of the venturi tube, and the microporous structure is not limited to a woven mesh or a perforated membrane or other loose porous structure, and preferably, the diameter of the micropores is between 1 and 15 microns. When the bubbles in the gas-liquid mixed phase flow through the sub-microporous structure, they are further cut to form microbubbles with a smaller volume. Of course, the pore size of the microporous structure can be adjusted and selected according to the size of the bubbles required in the end.

[0048] The technical solution of the present invention also provides a microbubble generating device, including: a syringe, an injection needle and the microbubble generating assembly described above, wherein the syringe is connected to the first connector 1, and the injection needle is connected to the end of the second connector 2 or the third connector 3. The preferred injection needle is a 18G, 20G or 22G needle. When in use, it is only necessary to inhale the injection liquid into the syringe, and then connect the syringe to the microbubble generating assembly, directly push the syringe, and the liquid in the syringe will enter the microbubble generating assembly for gas-liquid mixing, and when output by the injection needle, it is a liquid containing a large amount of stable microbubbles, which can be directly applied, and can better achieve the effect of imaging while improving work efficiency, and is convenient for diagnosis. In this embodiment, in order to improve the stability of liquid microbubbles in the fluid, a surfactant can be added to the liquid to reduce the merging rate of microbubbles in the liquid. The surfactant can be polysorbate, propylene glycol, polyethylene glycol, lecithin, poloxamer, glycerol, hypertonic saline, etc.

[0049] For the syringe, a 5ml syringe is preferably used (a 10ml syringe is usually used in the prior art, and 9ml of liquid phase and 1ml of gas phase are mixed), because the resistance will increase when flowing in the fluid channel 5 through the design of the microbubble generating component in the present technical solution, resulting in a greater resistance when the operator presses the syringe, increasing the burden on the operator. By selecting a 5ml syringe, at the same speed of pushing the syringe, the injection amount of the fluid per unit time can be reduced, thereby reducing the resistance of pushing the syringe and increasing the use effect of the operator. At the same time, due to the high bubble-making efficiency of the microbubble generating component in the above technical solution, nearly 1ml of gas can also be mixed into the 5ml liquid phase.

[0050] It should be understood that the above-mentioned embodiments are merely illustrative and not restrictive. Without departing from the basic principles of the present invention, various obvious or equivalent modifications or substitutions that can be made by those skilled in the art to the above-mentioned details will all be included in the scope of the claims of the present invention.

Claims

1. A microbubble generating component, characterized in that: include: A first connecting body and a second connecting body respectively provided with fluid channels; The first connector is provided with a syringe connector at one end and a first connecting section connected to the second connector at the other end, wherein the first connecting section is composed of a first straight section and a first contraction section; The second connector includes an integrally formed second connector section and a venturi tube, the first connector section is connected to the second connector section via the second connector section, and a gap cavity is provided between the first contraction section and the third contraction section of the venturi tube; a needle connector for connecting an injection needle is provided at one end of the venturi tube away from the second connector section; A plurality of air inlet channels connected to the gap cavity are provided on the side wall of the second connecting section, and the air inlet channels are communicated with the sterile air chamber.

2. The microbubble generating assembly according to claim 1, characterized in that: The second connecting section consists of a second straight section and a second contraction section, the second contraction section is a frustoconical contraction section, the inner diameter of the end of which is smaller than the maximum inner diameter of the third contraction section, the inner diameter of the second straight section is equal to the outer diameter of the first straight section, the inner diameter of the second contraction section is equal to the outer diameter of the corresponding part of the first contraction section, and the gap cavity is composed of the inner diameter of the third contraction section and the outer diameter of the first contraction section.

3. The microbubble generating assembly according to claim 1, characterized in that: A first straight hole is provided at the inner wall end of the first contraction section, the Venturi tube comprises a third contraction section, a third straight section and an expansion section, the first straight hole is gap-connected with the third straight section, and the diameter of the first straight hole is smaller than the inner diameter of the third straight section.

4. The microbubble generating assembly according to any one of claims 1 to 3, characterized in that: It also includes a third connector, which is respectively connected to the side wall of the first connector and the end of the second connector away from the second connecting section, the third connector is provided with the sterile air chamber connected to the air inlet channel, and the first connector is provided with a first through hole connected to the sterile air chamber; the needle connector is arranged on the outlet of the third connector.

5. The microbubble generating assembly according to claim 4, characterized in that: A first step groove is arranged on the inner wall of one end of the third connector, a sealing platform matching with the first step groove is arranged on the first connector, a sealing groove for placing an O-ring is arranged on the sealing platform, and the first through hole is arranged between the sealing platform and the first connecting section.

6. The microbubble generating assembly according to claim 5, characterized in that: An annular platform is arranged between the first through hole and the first connecting section, and the annular platform divides the sterile air chamber into a first air chamber and a second air chamber that are connected to each other. The first through hole is directly connected to the first air chamber; the gap cavity is connected to the second air chamber through the air inlet channel, and the connection point between the first air chamber and the second air chamber is far away from the air inlet channel.

7. The microbubble generating assembly according to claim 4, characterized in that: The second connector also includes a third connector section, which is connected to the expansion section of the venturi tube, and the outer side wall of the third connector section is a conical side wall. A second step groove matching the third connector section is provided in the third connector, and the second step groove is sealed and connected to the third connector section.

8. The microbubble generating assembly according to claim 7, characterized in that: A plurality of Venturi structures are arranged on the fluid passage between the second step groove and the needle connector, and a second through hole is opened on the throat of the Venturi structure and / or the flat fluid passage connected to the expansion section.

9. The microbubble generating assembly according to any one of claims 1 to 3 or 5 to 8, characterized in that: A microporous structure for breaking up bubbles is arranged on the fluid channel downstream of the venturi tube.

10. A microbubble generating device, characterized in that: include: A syringe, an injection needle, and a microbubble generating assembly as described in any one of claims 1 to 9, wherein the syringe is connected to the first connector, and the injection needle is connected to the end of the second connector or the third connector.

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