Multifunctional safe flushing system for hemodialysis

Abstract

The invention discloses a multifunctional safe flushing system for hemodialysis, and belongs to the technical field of blood purification. The system comprises an arterial blood extraction assembly, a venous blood transfusion assembly and a plasma purification treatment assembly, one end of the venous blood transfusion assembly is connected with one end of the arterial blood extraction assembly through a plasma separator, one end of the plasma purification treatment assembly is connected with the plasma separator, and the other end of the plasma purification treatment assembly is connected with the venous blood transfusion assembly. A multifunctional safe flushing mechanism is arranged at the position, close to the plasma separator, of the plasma purification treatment assembly. During flushing, due to the fact that the path from the multifunctional safe flushing mechanism to the adsorber in the plasma purification treatment assembly is short, the time needed for flushing is shortened, the effective treatment duration is guaranteed, the needed amount of saline water is reduced, the situation that the amount of human body fluid is excessively increased is avoided, and it is guaranteed that the saline water has the needed flushing pressure when flowing to the adsorber; and the washing effect on the adsorber is ensured.

Description

Technical Field

[0001] The invention relates to a multifunctional safe flushing system for hemodialysis, belonging to the technical field of blood purification. Background Art

[0002] Blood purification is also called dialysis in daily life. It usually refers to drawing blood out of the body, removing harmful substances and toxins in the blood through purification equipment, and purifying various cells and immune factors in the blood, so as to achieve the effect of purifying the blood. Blood purification mainly includes hemodialysis, blood filtration, blood exchange, etc., which is a treatment method. Hemodialysis uses the principle of semi-permeable membrane to draw blood out of the body, filter the blood through a hemodialyzer, supplement the patient's body with the substances needed, and expel harmful substances and toxins in the blood, so as to achieve the effect of purifying the blood. Hemofiltration uses the principle of convection to draw blood out of the body, filter the blood through a filter, supplement the patient's body with the substances needed, and expel harmful substances and toxins in the blood, so as to achieve the effect of purifying the blood.

[0003] For example, the Chinese patent document with the announcement number CN203354990U discloses a dual plasma molecule adsorption system, including an arterial blood end, a venous blood end and a plasma end, a plasma separator is connected between the arterial blood end and the venous blood end, the input end of the plasma end is connected to the plasma separator, and the output end is connected to the venous blood end, and the plasma end is provided with a series of anion resin adsorber and a neutral macroporous resin adsorber. The combination of the two adsorption principles of broad-spectrum adsorption and ion exchange adsorption can remove toxins of corresponding molecular weight and negatively charged toxins, and the broad-spectrum effect is combined with specificity, which can remove more thoroughly and purify the blood more.

[0004] However, the system still has the following shortcomings:

[0005] The adsorber is usually flushed by injecting saline from the anticoagulant injection port. Since the path from the anticoagulant injection port to the adsorber is long, on the one hand, the flushing time will be prolonged and the amount of saline required will be increased, resulting in an excessive increase in the patient's body fluid volume; on the other hand, the pressure of the saline will be significantly reduced when it flows to the adsorber, further resulting in a decrease in its flushing effect on the adsorber. Summary of the invention

[0006] In order to solve the above technical problems, the present invention provides a multifunctional safe flushing system for hemodialysis.

[0007] The present invention is achieved through the following technical solutions:

[0008] A multifunctional safety flushing system for hemodialysis comprises an arterial blood extraction component, a venous blood reinfusion component and a plasma purification component, wherein one end of the venous blood reinfusion component is connected to one end of the arterial blood extraction component via a plasma separator, one end of the plasma purification component is connected to the plasma separator, and the other end is connected to the venous blood reinfusion component, and a multifunctional safety flushing mechanism is provided on the plasma purification component near the plasma separator.

[0009] The arterial blood extraction assembly comprises an arterial blood extraction tube, a blood pump and an arterial pot. One end of the arterial blood extraction tube is connected to a plasma separator. Both the blood pump and the arterial pot are installed on the arterial blood extraction tube, and the arterial pot is located between the blood pump and the plasma separator.

[0010] The venous blood return component comprises a venous blood return tube and a venous pot. One end of the venous blood return tube is connected to the plasma separator, and the venous pot is installed on the venous blood return tube.

[0011] The plasma purification treatment component includes a plasma delivery tube, an anion exchange resin adsorber and a plasma pump which are sequentially installed on the plasma delivery tube, and the anion exchange resin adsorber is arranged close to the plasma separator. One end of the plasma delivery tube is connected to the plasma separator, and the other end is connected to the intravenous pot.

[0012] A neutral macroporous resin adsorber is also installed on the plasma delivery tube between the anion exchange resin adsorber and the plasma pump.

[0013] The multifunctional safety flushing mechanism is arranged on the plasma conveying tube and is located between the anion exchange resin adsorber and the plasma separator.

[0014] The multifunctional safety flushing mechanism comprises a pipeline conversion component and a liquid input component. The pipeline conversion component is installed on the plasma delivery tube, and the liquid input component is connected to the pipeline conversion component through a connecting tube.

[0015] The pipeline conversion assembly includes a mixing box, a flushing port is provided on the top of the mixing box, a reversing valve A is provided at one end of the mixing box away from the plasma separator, and a reversing valve B is provided at the other end, and both the reversing valve A and the reversing valve B are provided with an internal thread connector and a Hans connector.

[0016] The reversing valve A is a two-position three-way solenoid valve, the reversing valve B is a three-position three-way solenoid valve, and a pressure sensor is provided on the mixing box.

[0017] The liquid input component is a saline bag, and a valve is arranged on the connecting pipe.

[0018] The beneficial effects of the present invention are:

[0019] 1. When it is necessary to flush the plasma purification component, saline is injected into the plasma purification component through the multifunctional safety flushing mechanism. Since the multifunctional safety flushing mechanism is installed on the plasma purification component close to the plasma separator, the path from the multifunctional safety flushing mechanism to the adsorber in the plasma purification component is significantly shortened, which not only shortens the time required for flushing, ensures the effective treatment time, reduces the amount of saline required, avoids excessive increase in human body fluid volume, but also ensures that the saline has the required flushing pressure when it flows to the adsorber, ensuring its effective flushing effect on the adsorber.

[0020] 2. The anion exchange resin adsorber is arranged between the plasma pump and the multifunctional safety flushing mechanism, that is, the plasma pump is arranged behind the anion exchange resin adsorber to further shorten the path from the multifunctional safety flushing mechanism to the anion exchange resin adsorber, which not only shortens the flushing time and reduces the required amount of brine, but also reduces the pressure drop when the brine flows to the anion exchange resin adsorber, thereby ensuring its flushing effect on the anion exchange resin adsorber.

[0021] 3. The pipeline conversion assembly is connected to the outer thread joint or Hans joint at the end of the plasma delivery tube through the inner thread joint, Hans joint, to ensure the tightness and reliability of the connection between the pipeline conversion assembly and the plasma delivery tube, and to avoid loose connection of the pipeline and bleeding, which may increase the risk of infection.

[0022] 4. The reversing valve A and reversing valve B at the end of the mixing box are equipped with two connection ports for plasma separators currently commonly used in clinical practice: female thread connector and Hans connector. The corresponding connection port can be selected for connection according to actual needs, eliminating the impact caused by different end connectors of pipelines of dialysis equipment, instruments, etc. from different manufacturers, while reducing the frequency of replacement and disassembly of pipelines or connectors, further reducing the risk of infection.

[0023] 5. After injecting saline into the mixing box, the load on the plasma pump will increase, causing the pressure in the mixing box to fluctuate. Therefore, a pressure sensor is installed on the mixing box to detect the pressure of the mixing box in real time, which helps to avoid blockage caused by excessive pressure in the pipe.

[0024] 6. Before flushing, adjust the reversing valve B to the middle cut-off position to prevent the plasma separated by the plasma separator from continuing to flow into the mixing box, anion exchange resin adsorber, neutral macroporous resin adsorber and plasma pump, etc., while ensuring the effective flushing effect of saline on the anion exchange resin adsorber and the neutral macroporous resin adsorber, it can significantly reduce the amount of saline required for flushing and avoid excessive increase in human body fluid volume. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 This is a schematic diagram of the structure when the present invention is only used for bilirubin adsorption;

[0026] Figure 2 It is a schematic diagram of the structure of the present invention when it has dual plasma molecule adsorption function;

[0027] Figure 3 It is a schematic diagram of the assembly structure of the pipeline conversion assembly and the pressure sensor of the present invention;

[0028] Figure 4 It is a structural schematic diagram of the reversing valve A of the present invention;

[0029] Figure 5 It is a structural schematic diagram of the reversing valve B of the present invention.

[0030] In the figure: 1-human body, 2-blood pump, 3-arterial blood lead tube, 4-arterial pot, 5-plasma delivery tube, 6-liquid input assembly, 60-valve, 7-pressure sensor, 8-pipeline conversion assembly, 80-mixing box, 81-flushing port, 82-reversing valve A, 83-female thread connector, 84-Hans connector, 85-reversing valve B, 9-plasma pump, 11-anion exchange resin adsorber, 12-neutral macroporous resin adsorber, 13-plasma separator, 14-venous pot, 15-venous blood return tube. DETAILED DESCRIPTION

[0031] The technical solution of the present invention is further described below, but the scope of protection claimed is not limited to the description.

[0032] like Figures 1 to 5As shown, a multifunctional safe flushing system for hemodialysis described in the present invention comprises an arterial blood lead-out component, a venous blood return component and a plasma purification component, one end of the venous blood return component is connected to one end of the arterial blood lead-out component through a plasma separator 13, one end of the plasma purification component is connected to the plasma separator 13, and the other end is connected to the venous blood return component, and a multifunctional safe flushing mechanism is provided on the plasma purification component near the plasma separator 13. When in use, the blood in the human body 1 is led out of the body through the arterial blood lead-out component, and then the blood is separated into plasma through the plasma separator 13, and the plasma is purified by the plasma purification component and then merged with blood cells in the venous blood return component, and finally the blood is returned to the human body 1 through the venous blood return component to achieve the purpose of blood purification or hemodialysis. When the plasma purification treatment component needs to be flushed, saline is injected into the plasma purification treatment component through the multifunctional safety flushing mechanism. Since the multifunctional safety flushing mechanism is installed on the plasma purification treatment component near the plasma separator 13, the path from the multifunctional safety flushing mechanism to the adsorber in the plasma purification treatment component is significantly shortened, which not only shortens the time required for flushing, ensures the effective treatment time, reduces the amount of saline required, avoids excessive increase in the body fluid volume of the human body 1, but also ensures that the saline has the required flushing pressure when it flows to the adsorber, thereby ensuring its flushing effect on the adsorber.

[0033] The arterial blood extraction assembly includes an arterial blood extraction tube 3, a blood pump 2 and an arterial pot 4, one end of the arterial blood extraction tube 3 is connected to the plasma separator 13, the blood pump 2 and the arterial pot 4 are both installed on the arterial blood extraction tube 3, and the arterial pot 4 is located between the blood pump 2 and the plasma separator 13. When in use, the end of the arterial blood extraction tube 3 away from the plasma separator 13 is connected to the arterial blood vessel of the human body 1 through a needle.

[0034] The venous blood return assembly includes a venous blood return tube 15 and a venous pot 14, one end of the venous blood return tube 15 is connected to the plasma separator 13, and the venous pot 14 is installed on the venous blood return tube 15. When in use, one end of the venous blood return tube 15 is connected to the venous blood vessel of the human body 1 through a needle.

[0035] The plasma purification treatment component includes a plasma delivery tube 5, an anion exchange resin adsorber 11 and a plasma pump 9 which are sequentially installed on the plasma delivery tube 5, and the anion exchange resin adsorber 11 is arranged close to the plasma separator 13, one end of the plasma delivery tube 5 is connected to the plasma separator 13, and the other end is connected to the intravenous pot 14. When in use, the anion exchange resin adsorber 11 is filled with BS ion exchange resin, which is a specific adsorbent for bilirubin, and relies on electrostatic force and lipophilic binding to specifically adsorb bilirubin, bile acid and other toxins. Unlike the prior art in which the plasma pump 9 is arranged in front of the anion exchange resin adsorber 11, the present invention arranges the anion exchange resin adsorber 11 between the plasma pump 9 and the multifunctional safety flushing mechanism, that is, the plasma pump 9 is arranged behind the anion exchange resin adsorber 11, so as to further shorten the path from the multifunctional safety flushing mechanism to the anion exchange resin adsorber 11, thereby shortening the flushing time required, ensuring the effective treatment time, reducing the amount of saline required, avoiding the situation of excessive increase in the body fluid volume of the human body 1, and reducing the pressure drop when the saline flows to the anion exchange resin adsorber 11, thereby ensuring its flushing effect on the anion exchange resin adsorber 11.

[0036] A neutral macroporous resin adsorber 12 is also installed on the plasma delivery tube 5 between the anion exchange resin adsorber 11 and the plasma pump 9. When in use, the neutral macroporous resin adsorber 12 is a HA blood perfusion device, which has HA neutral macroporous resin inside. The HA neutral macroporous resin is a broad-spectrum adsorbent with a macroporous structure and a large surface area. It relies on van der Waals forces and skeleton molecular sieve effects to adsorb medium and macromolecular toxins, such as hepatic encephalopathy substances, inflammatory mediators, etc.

[0037] The multifunctional safety flushing mechanism is arranged on the plasma delivery tube 5 and is located between the anion exchange resin adsorber 11 and the plasma separator 13 .

[0038] The multifunctional safety flushing mechanism comprises a pipeline conversion assembly 8 and a liquid input assembly 6. The pipeline conversion assembly 8 is installed on the plasma delivery tube 5, and the liquid input assembly 6 is connected to the pipeline conversion assembly 8 through a connecting pipe.

[0039] The pipeline conversion assembly 8 includes a mixing box 80, a flushing port 81 is provided on the top of the mixing box 80, a reversing valve A82 is provided at one end of the mixing box 80 away from the plasma separator 13, and a reversing valve B85 is provided at the other end, and both the reversing valve A82 and the reversing valve B85 are provided with an internal thread connector 83 and a Hans connector 84. When in use, the saline bag is connected to the flushing port 81 on the mixing box 80 through a connecting pipe, and the saline bag is communicated with the inside of the mixing box 80 through the connecting pipe.

[0040] Generally, a tee is often used at the installation position of the pipeline conversion component 8 to connect the plasma delivery tube 5 with the connecting tube. However, the connection tightness and reliability between the plasma delivery tube 5 and the tee are poor, and their connection is prone to loosening and bleeding, resulting in an increased risk of infection. In addition, since the joints used in the pipelines of dialysis equipment, instruments, etc. produced by different manufacturers are uneven, some pipelines are connected with internal and external thread joints, while some pipelines are connected with Hans joints 84, which requires frequent replacement and disassembly of pipelines or joints to achieve pipeline connection. However, frequent replacement and disassembly of pipelines or joints will also cause a significant increase in the risk of infection.

[0041] Based on the above two reasons, the present invention designs a pipeline conversion assembly 8 to connect with the outer thread joint or Hans joint 84 at the end of the plasma delivery tube 5 through the inner thread joint 83 and the Hans joint 84, so as to ensure the tightness and reliability of the connection between the pipeline conversion assembly 8 and the plasma delivery tube 5, and avoid the situation where the pipeline connection becomes loose and leaks blood, resulting in an increased risk of infection; the inner thread joint 83 and the Hans joint 84 are installed on the reversing valve A82 and the reversing valve B85 at the end of the mixing box 80. Regardless of whether the end of the plasma delivery tube 5 is an outer thread joint or a Hans joint 84, the plasma delivery tube 5 can be tightly and reliably connected to the pipeline conversion assembly 8, eliminating the influence caused by the different end joints of the dialysis equipment, instruments, etc. from different manufacturers, while reducing the frequency of replacing and disassembling pipelines or joints, further reducing the risk of infection.

[0042] A reversing valve A82 and a reversing valve B85 are installed at the end of the mixing box 80 to switch between the internal thread connector 83 and the Hans connector 84, thereby preventing the liquid in the mixing box 80 from leaking from unused connectors, thereby ensuring that the mixing box 80 has good sealing performance and reducing the risk of infection. In addition, screw plugs or the like can be used to pre-block unused connectors on the reversing valve A82 and the reversing valve B85 to further improve the sealing performance of the pipeline conversion assembly 8 and reduce the risk of infection.

[0043] The reversing valve A82 is a two-position three-way solenoid valve, the reversing valve B85 is a three-position three-way solenoid valve, and a pressure sensor 7 is provided on the mixing box 80. After the saline is injected into the mixing box 80, the load of the plasma pump 9 will increase, resulting in pressure fluctuations in the mixing box 80. Therefore, the pressure sensor 7 is installed on the mixing box 80 to detect the pressure of the mixing box 80 in real time, which helps to avoid blockage caused by excessive pressure in the pipe.

[0044] The liquid input assembly 6 is a saline bag, and a valve 60 is provided on the connecting pipe. The valve 60 is used to control the opening and closing of the connecting pipe to achieve the purpose of controlling whether the saline or other liquid is injected into the mixing box 80.

[0045] The multifunctional safe flushing system for hemodialysis of the present invention has the following working principle or use process:

[0046] like Figures 3 to 5 As shown, the reversing valve B85 is a three-position three-way solenoid valve, the A port on it is connected to the inside of the mixing box 80, and the P port and the R port are used to install the internal thread connector 83 and the Hans connector 84 accordingly; the reversing valve A82 is a two-position three-way solenoid valve, the A port on it is connected to the inside of the mixing box 80, and the P port and the R port are used to install the internal thread connector 83 and the Hans connector 84 accordingly. According to actual use, the internal thread connector 83 on the reversing valve B85 can be selected to be connected to the internal thread connector 83 or the Hans connector 84 on the reversing valve A82, and similarly, the Hans connector 84 on the reversing valve B85 can also be selected to be connected to the internal thread connector 83 or the Hans connector 84 on the reversing valve A82, which significantly improves the practicality and flexibility of use of the pipeline conversion assembly 8.

[0047] 1. Treatment Model

[0048] Under the action of the blood pump 2, the blood in the human body 1 is led out of the body through the arterial blood outlet tube, and then the blood is separated into plasma through the plasma separator 13. Under the action of the plasma pump 9, the plasma flows through the pipeline conversion component 8, the anion exchange resin adsorber 11, the neutral macroporous resin adsorber 12 and the plasma pump 9 in sequence, and the toxins in the plasma are adsorbed by the anion exchange resin adsorber 11 and the neutral macroporous resin adsorber 12 to achieve the purpose of purifying the plasma. The purified plasma and blood cells are merged in the venous pot 14, and then returned to the human body 1 through the venous blood return tube 15, thus completing a treatment cycle.

[0049] 2. Flushing Mode

[0050] When the anion exchange resin adsorber 11 and the neutral macroporous resin adsorber 12 need to be flushed, the reversing valve B85 is in the middle cut-off position, and the P port and the R port on it are not connected to the A port, so that the plasma separated by the plasma separator 13 no longer continues to flow into the mixing box 80, the anion exchange resin adsorber 11, the neutral macroporous resin adsorber 12 and the plasma pump 9. Next, the valve 60 on the connecting pipe is opened, and the saline in the saline bag is injected into the mixing box 80, and then the saline flows through the anion exchange resin adsorber 11 and the neutral macroporous resin adsorber 12 under the action of the plasma pump 9 to achieve flushing.

[0051] Since the path from the liquid input assembly 6 to the anion exchange resin adsorber 11 and the neutral macroporous resin adsorber 12 is short, only relatively small pressure and a small amount of brine are required to ensure the effective flushing effect of the brine on the anion exchange resin adsorber 11 and the neutral macroporous resin adsorber 12.

[0052] In addition, before flushing, the reversing valve B85 is adjusted to the middle cut-off position to prevent the plasma separated by the plasma separator 13 from continuing to flow into the mixing box 80, the anion exchange resin adsorber 11, the neutral macroporous resin adsorber 12 and the plasma pump 9, etc., while ensuring the effective flushing effect of the saline on the anion exchange resin adsorber 11 and the neutral macroporous resin adsorber 12, the amount of saline required for flushing can be significantly reduced to avoid excessive increase in the body fluid volume of the human body 1.

Claims

1. A multifunctional safety flushing system for hemodialysis, characterized in that: The invention comprises an arterial blood extraction component, a venous blood return component and a plasma purification component. One end of the venous blood return component is connected to one end of the arterial blood extraction component via a plasma separator (13). One end of the plasma purification component is connected to the plasma separator (13), and the other end is connected to the venous blood return component. A multifunctional safety flushing mechanism is provided on the plasma purification component at a position close to the plasma separator (13).

2. The multifunctional safe flushing system for hemodialysis according to claim 1, characterized in that: The arterial blood extraction assembly comprises an arterial blood extraction tube (3), a blood pump (2) and an arterial pot (4); one end of the arterial blood extraction tube (3) is connected to a plasma separator (13); the blood pump (2) and the arterial pot (4) are both installed on the arterial blood extraction tube (3), and the arterial pot (4) is located between the blood pump (2) and the plasma separator (13).

3. The multifunctional safe flushing system for hemodialysis according to claim 1, characterized in that: The venous blood return component comprises a venous blood return tube (15) and a venous pot (14), one end of the venous blood return tube (15) is connected to the plasma separator (13), and the venous pot (14) is installed on the venous blood return tube (15).

4. The multifunctional safe flushing system for hemodialysis according to claim 3, characterized in that: The plasma purification treatment component comprises a plasma delivery tube (5), an anion exchange resin adsorber (11) and a plasma pump (9) which are sequentially mounted on the plasma delivery tube (5), and the anion exchange resin adsorber (11) is arranged close to a plasma separator (13), one end of the plasma delivery tube (5) is connected to the plasma separator (13), and the other end is connected to a venous pot (14).

5. The multifunctional safe flushing system for hemodialysis according to claim 4, characterized in that: A neutral macroporous resin adsorber (12) is also installed on the plasma transport tube (5) between the anion exchange resin adsorber (11) and the plasma pump (9).

6. The multifunctional safe flushing system for hemodialysis according to claim 4, characterized in that: The multifunctional safety flushing mechanism is arranged on the plasma delivery tube (5) and is located between the anion exchange resin adsorber (11) and the plasma separator (13).

7. The multifunctional safe flushing system for hemodialysis according to claim 6, characterized in that: The multifunctional safety flushing mechanism comprises a pipeline conversion component (8) and a liquid input component (6), wherein the pipeline conversion component (8) is installed on the plasma delivery tube (5), and the liquid input component (6) is connected to the pipeline conversion component (8) via a connecting tube.

8. The multifunctional safe flushing system for hemodialysis according to claim 7, characterized in that: The pipeline conversion assembly (8) comprises a mixing box (80), a flushing port (81) is provided at the top of the mixing box (80), a reversing valve A (82) is provided at one end of the mixing box (80) away from the plasma separator (13), and a reversing valve B (85) is provided at the other end, and both the reversing valve A (82) and the reversing valve B (85) are provided with an internal thread connector (83) and a Hans connector (84).

9. The multifunctional safe flushing system for hemodialysis according to claim 8, characterized in that: The reversing valve A (82) is a two-position three-way solenoid valve, the reversing valve B (85) is a three-position three-way solenoid valve, and a pressure sensor (7) is provided on the mixing box (80).

10. The multifunctional safe flushing system for hemodialysis according to claim 7, characterized in that: The liquid input component (6) is a saline bag, and a valve (60) is provided on the connecting pipe.

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