Vibsane-type diterpenoid compounds or salts thereof having a seven-membered ring skeleton characteristic in Japanese coral tree and preparation method and application thereof
By extracting and isolating vibsane-type diterpenoids from Japanese coral trees, the problem of insufficient antitumor drugs in existing technologies has been solved, and a variety of compounds with antitumor activity have been provided for cancer treatment.
CN119285592BActive Publication Date: 2026-05-26SHENYANG PHARMA UNIV
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHENYANG PHARMA UNIV
- Filing Date
- 2024-10-08
- Publication Date
- 2026-05-26
AI Technical Summary
Technical Problem
The lack of effective anti-tumor natural products in existing technologies has led to insufficient development of cancer treatment drugs, especially those with insufficient anti-tumor activity.
Method used
Vibsane-type diterpenoids or their salts were extracted and isolated from the dried leaves of the Japanese coral tree (Viburnum awabuki), and 15 compounds with antitumor activity were prepared by multi-step chromatographic and liquid-phase purification methods.
Benefits of technology
A variety of vibsane-type diterpenoids with different structures and activities are provided for the preparation of antitumor drugs, enhancing the drug selection and efficacy of cancer treatment.
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Figure CN119285592B_ABST
Abstract
This invention belongs to the field of natural product chemistry, and relates to characteristic vibsane-type diterpenoids with a seven-membered ring skeleton from *Viburnum awabuki*, or their salts, as well as their preparation methods and applications. Specifically, this invention relates to 15 vibsane-type diterpenoids with a seven-membered ring skeleton extracted and isolated from the dried leaves of *Viburnum awabuki*, a plant in the Viburnaceae family. The vibsane-type diterpenoids were isolated by silica gel column chromatography, HP20 macroporous resin column chromatography, ODS column chromatography, and HPLC. The antitumor activity of these compounds was investigated by testing their inhibitory effects on three tumor cell lines: HepG2, A549, and MCF-7.
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