Model for simulating human thoracic-pulmonary respiration tumor and manufacturing method thereof

By assembling shell molds and flexible materials to create a tumor model that simulates human chest and lung breathing, the problem of inability to accurately simulate tumor displacement changes in the prior art is solved, dynamic changes in the lungs and chest are achieved, and the accuracy of radiation therapy is improved.

CN119296424AActive Publication Date: 2025-01-10SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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Patent Information

Application Number
CN202411477360.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-10-22
Publication Date
2025-01-10
Estimated Expiration
2044-10-22

AI Technical Summary

Technical Problem

The prior art cannot accurately simulate the changes in tumor displacement caused by human breathing, and cannot achieve the effect of swelling changes in lung breathing and the linkage between chest and abdomen, affecting the accuracy of radiation therapy.

Method used

Multiple shell molds are used to assemble to form the lung shell mold, and a hollow respiratory cavity structure is formed using flexible materials. The tumor is simulated by injecting liquid flexible materials and metal balls, and a 3D printing technology is combined to create a human chest and lung respiratory tumor model to realize Dynamic changes in the lungs and chest.

Benefits of technology

By simulating human breathing, the displacement changes of the tumor during breathing are accurately judged, which improves the accuracy of radiation therapy.

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Abstract

The invention discloses a model for simulating human thoracic-pulmonary respiration tumor and a manufacturing method thereof, and belongs to the field of medical instruments, a plurality of shell molds are assembled to form a lung shell mold with a cavity, a flexible material is adopted to form a hollow respiration cavity structure, a liquid flexible material is injected into the cavity according to the position of the tumor, and the lung shell mold and the respiration cavity structure are combined to form the model. Putting the flexible material into a metal ball for simulating tumors after the flexible material is solidified, putting the breathing cavity structure into a cavity, continuously injecting the liquid flexible material and putting the metal ball according to the number and the position of the tumors until the cavity is filled with the tumors to form a lung model containing a tumor model, and sleeving the rib model into the lung model, a plurality of split molds are folded to the lung model to form a chest mold, a liquid flexible material is injected into the chest mold, curing and demolding are performed to obtain the chest and lung respiration tumor model, and the manufactured simulated human body chest and lung respiration tumor model simulates human body respiration through inflation or deflation. And the displacement change of the tumor caused by breathing in the breathing process can be accurately judged.
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Description

Technical Field

[0001] The invention relates to the field of medical devices, and in particular to a human chest and lung breathing tumor model simulating a human body and a manufacturing method thereof. Background Art

[0002] Most radiotherapy for chest tumors is performed from outside the body. The accuracy of the radiation position is very high during radiotherapy. During the treatment, the patient cannot move or can only move very slightly. If the patient moves or breathes too much, the treated area may move out of the treatment target area, affecting the treatment effect.

[0003] In the prior art, a lung breathing model is established to determine the position of the tumor in different patient postures. However, most lung breathing models are made of rigid materials and can only achieve a similar appearance but cannot simulate the breathing effect and the displacement change of the tumor caused by human breathing. Or, the model can only simulate the breathing principle but cannot achieve the effect of the lung's breathing expansion change, and cannot be combined with the human chest and abdomen to achieve a respiratory linkage effect. Therefore, it is difficult to accurately determine the displacement change of the tumor caused by breathing during the breathing process. Summary of the invention

[0004] In order to overcome the deficiencies of the prior art, one of the objectives of the present invention is to provide a method for making a simulated human chest and lung breathing tumor model that can accurately determine the displacement changes of the tumor caused by breathing during breathing.

[0005] In order to overcome the deficiencies of the prior art, a second object of the present invention is to provide a simulated human chest and lung breathing tumor model that can accurately determine the displacement changes of the tumor caused by breathing during the breathing process.

[0006] One of the purposes of the present invention is achieved by the following technical solution:

[0007] A method for making a human chest and lung breathing tumor model, comprising the following steps:

[0008] Making a lung shell mold: assembling a plurality of shell molds to form a lung shell mold, wherein a cavity is formed inside the lung shell mold;

[0009] Making a breathing cavity structure: using a flexible material to form a hollow breathing cavity structure, wherein a flexible tube is provided on the breathing cavity structure, and the flexible tube is connected to the internal hollow structure;

[0010] Lung model forming: according to the location of the tumor, liquid flexible material is injected into the mold cavity, and metal balls are placed after the flexible material solidifies, the metal balls are used to simulate the tumor, at least one of the shells is disassembled to open the mold cavity, two breathing cavity structures are placed in the mold cavity, and the disassembled shells are installed in the lung shell mold. According to the number and location of the tumor, liquid flexible material is continuously injected and metal balls are placed until the mold cavity is filled, and a lung model containing a tumor model is formed inside the lung shell mold;

[0011] Chest model forming: the rib model is inserted into the lung model, and multiple separate molds are closed and assembled with the lung model as the center to form a chest mold. The flexible tube extends from the rib model and the chest mold, and liquid flexible material is injected into the chest mold. After curing, the chest and lung respiratory tumor model is demolded.

[0012] Furthermore, the steps for making the breathing cavity structure are specifically as follows: placing the inner cavity mold in the outer cavity mold, injecting liquid flexible material between the inner cavity mold and the outer cavity mold, allowing the liquid flexible material to solidify to form a main body, taking the main body out from between the inner cavity mold and the outer cavity mold, and placing the main body into a cavity bottom mold with liquid flexible material to form a sealing surface on the main body, wherein the sealing surface is provided with a connecting hole, and the flexible tube is fixed to the connecting hole.

[0013] Furthermore, the flexible material is silicone.

[0014] Furthermore, the lung model is made of silicone E615, the breathing cavity structure is made of silicone E615, and the chest model is made of silicone G05.

[0015] Furthermore, in the lung model forming step, the metal ball is a tungsten ball.

[0016] Furthermore, the method for making a simulated human chest and lung respiratory tumor model also includes obtaining human data. The step of obtaining human data is located before the step of making a lung shell mold. The step of obtaining human data specifically includes: obtaining human medical images, obtaining tumor quantity, size, and location information based on the medical images, and obtaining human lung, rib and chest size data.

[0017] Furthermore, in the step of making the lung shell mold, a plurality of the shell molds are made by 3D printing according to the human lung size data, and in the chest model forming step, the split mold is made by 3D printing according to the human chest data.

[0018] Furthermore, in the production of the lung shell mold, the number of the shell molds is three, and the three shell molds are respectively a first shell mold, a second shell mold and a third shell mold. The first shell mold and the second shell mold are assembled to form a half lung model. The first shell mold is located above the second shell mold. The first shell mold is provided with a feeding hole, and the feeding hole is located at the top of the first shell mold. The third shell mold is fixed to the first shell mold and the second shell mold to form the lung shell mold together.

[0019] The second object of the present invention is achieved by adopting the following technical solution:

[0020] A human chest and lung breathing tumor model is manufactured by any of the above-mentioned methods for manufacturing a human chest and lung breathing tumor model. The human chest and lung breathing tumor model comprises a chest model, a rib model, a lung model and a tumor model. The lung model is made of a flexible material, the lung model is a hollow structure and is connected to the outside through a flexible tube. The tumor model is embedded in the lung model, the rib model is sleeved on the outside of the lung model, and the chest model is formed on the outside of the rib model. The chest model is made of a flexible material, and can simulate human breathing by inflating or deflating the flexible tube.

[0021] Furthermore, the lung model is made of silicone E615, and the chest model is made of silicone G05.

[0022] Compared with the prior art, the method for making a model of a simulated human chest and lung respiratory tumor of the present invention uses multiple shell molds to assemble to form a lung shell mold, a cavity is formed inside the lung shell mold, a hollow respiratory cavity structure is formed by using a flexible material, a flexible tube is provided on the respiratory cavity structure, and the flexible tube is connected to the internal hollow structure. According to the location of the tumor, liquid flexible material is injected into the cavity, and a metal ball is placed in it after the flexible material solidifies. The metal ball is used to simulate the tumor, and at least one of the shells is disassembled to open the cavity, and the respiratory cavity structure is placed in the cavity. The disassembled shell is installed in the lung shell mold, and according to the number of tumors and Liquid flexible material is continuously injected into the position and metal balls are placed until the mold cavity is filled, a lung model containing a tumor model is formed inside the lung shell mold, the rib model is inserted into the lung model, and multiple split molds are closed and assembled with the lung model as the center to form a chest mold, the flexible tube extends from the rib model and the chest mold, liquid flexible material is injected into the chest mold, and the chest mold is demolded after curing to obtain a chest-lung breathing tumor model. Through the above steps, the manufactured simulated human chest-lung breathing tumor model can simulate human breathing by inflation or deflation, thereby accurately judging the displacement change of the tumor caused by breathing during the breathing process. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 This is a flow chart of the method for making a human chest and lung breathing tumor model simulated by the present invention;

[0024] Figure 2 It is a three-dimensional diagram of the lung shell mold;

[0025] Figure 3 for Figure 2 A three-dimensional view of a first shell mold of a lung shell mold;

[0026] Figure 4 for Figure 2 A perspective view of a second shell mold of the lung shell mold;

[0027] Figure 5 for Figure 2 A three-dimensional view of an opened state of a lung housing mold;

[0028] Figure 6 is a three-dimensional image of the outer mold of the cavity;

[0029] Figure 7 is a three-dimensional image of the mold inside the cavity;

[0030] Figure 8 is a three-dimensional diagram of a cavity bottom sealing mold;

[0031] Fig. 9 It is a three-dimensional diagram of the structure of the respiratory cavity;

[0032] Fig.10 A three-dimensional image of a breast mold;

[0033] Fig.11 It is a stereoscopic image of a chest and lung respiratory tumor model;

[0034] Fig.12 This is a three-dimensional diagram of the internal structure of the chest and lung respiratory tumor model.

[0035] In the figure: 10, lung shell mold; 11, first shell mold; 110, feeding hole; 111, first fixing hole; 112, second fixing hole; 12, second shell mold; 120, third fixing hole; 13, third shell mold; 130, fourth fixing hole; 14, cavity; 21, cavity external mold; 22, cavity internal mold; 23, cavity bottom mold; 230, bottom plate; 231, extension column; 30, breathing cavity structure; 31, main body; 32, sealing surface; 33, flexible tube; 40, chest mold; 41, split mold; 410, pouring port; 100, chest and lung breathing tumor model; 101, chest model; 102, rib model; 103, lung model; 104, tumor model. DETAILED DESCRIPTION

[0036] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0037] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art of the present invention. The terms used herein in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more related listed items.

[0038] See also Figure 1 The present invention provides a method for preparing a human chest and lung breathing tumor model, comprising the following steps:

[0039] Making a lung shell mold: assembling a plurality of shell molds to form a lung shell mold, and forming a cavity inside the lung shell mold;

[0040] Making a breathing cavity structure: using a flexible material to form a hollow breathing cavity structure, a flexible tube is provided on the breathing cavity structure, and the flexible tube is connected to the internal hollow structure;

[0041] Lung model forming: according to the location of the tumor, liquid flexible material is injected into the mold cavity, and metal balls are placed after the flexible material solidifies. The metal balls are used to simulate the tumor. At least one shell is disassembled to open the mold cavity, and two breathing cavity structures are placed in the mold cavity. The disassembled shell is installed into the lung shell mold. According to the number and location of the tumor, liquid flexible material is continuously injected and metal balls are placed until the mold cavity is filled. A lung model containing a tumor model is formed inside the lung shell mold.

[0042] Chest model forming: The rib model is inserted into the lung model, and multiple split molds are closed and assembled with the lung model as the center to form a chest mold. A flexible tube extends from the rib model and the chest mold, and liquid flexible material is injected into the chest mold. After curing, the mold is demolded to obtain a chest and lung respiratory tumor model.

[0043] The method for making a simulated human chest and lung breathing tumor model also includes obtaining human data. The step of obtaining human data is located before the step of making a lung shell mold. The step of obtaining human data is specifically: obtaining human medical images, obtaining the number, size, and location information of tumors based on the medical images, and obtaining human lung, rib, and chest size data. The human medical images are obtained using CT, and three-dimensional models of the lungs, tumors, ribs, and chest are obtained based on the human medical images.

[0044] Please continue reading Figures 2 to 3 The lung shell mold 10 is specifically made as follows: the lung shell mold 10 is formed by detachable assembly of multiple shell molds, so that the breathing cavity structure 30 can be placed in the lung shell mold 10 and the lung model 103 can be demolded after molding. Specifically, the number of shell molds is three, and the three shell molds are respectively a first shell mold 11, a second shell mold 12, and a third shell mold 13. The first shell mold 11, the second shell mold 12, and the third shell mold 13 are all formed by 3D printing based on lung data obtained from human medical images.

[0045] The first shell mold 11 is a quarter structure, and a feeding hole 110 is provided on the top of the first shell mold 11 to facilitate the subsequent addition of liquid flexible material. The first shell mold 11 is provided with a first fixing hole 111 and a second fixing hole 112. The first fixing hole 111 is located inside the first shell mold 11, and the second fixing hole 112 is located at the bottom of the first shell mold 11. The first fixing hole 111 is used to fix the first shell mold 11 and the third shell mold 13, and the second fixing hole 112 is used to fix the first shell mold 11 and the second shell mold 12.

[0046] The second housing mold 12 is a quarter structure. The second housing mold 12 is provided with a third fixing hole 120 , and the third fixing hole 120 is fixed to the first housing mold 11 .

[0047] The third housing mold 13 is a half structure. The third housing mold 13 is provided with a fourth fixing hole 130 , and the fourth fixing hole 130 is fixed to the first housing mold 11 .

[0048] The first shell mold 11 , the second shell mold 12 and the third shell mold 13 are fixed to each other to form a lung shell mold 10 . The lung shell mold 10 is a hollow structure with a cavity 14 formed inside.

[0049] Please continue reading Figures 6 to 9The specific steps of making the breathing cavity structure 30 are as follows: placing the inner cavity mold 22 in the outer cavity mold 21, injecting liquid flexible material between the inner cavity mold 22 and the outer cavity mold 21, and allowing the liquid flexible material to solidify to form a main body 31, taking the main body 31 out from between the inner cavity mold 22 and the outer cavity mold 21, and placing the main body 31 into the cavity bottom mold 23 with liquid flexible material to form a sealing surface 32 on the main body 31, and providing a connecting hole on the sealing surface 32, and fixing the flexible tube 33 to the connecting hole.

[0050] Specifically, the outer mold 21 of the cavity is rectangular and has a hollow structure. The inner mold 22 of the cavity is rectangular and has a hollow structure. The cavity bottom mold 23 includes a bottom plate 230 and an extension column 231 extending from the bottom plate 230, and the extension column 231 is used to form a connection hole. The flexible material is silicone, and further, Guoyuan silicone E615 is used. The outer mold 21 of the cavity, the inner mold 22 of the cavity, and the cavity bottom mold 23 are all formed by 3D printing based on lung data obtained from human medical images. The flexible tube 33 is a silicone tube and is bonded to the connection hole with silicone glue.

[0051] During the molding step of the lung model 103, the number, size, and location information of the tumor can be obtained through human medical imaging. Taking a tumor as an example, the molding process of the lung model 103 is explained: liquid flexible material is injected into the mold cavity 14 through the feeding hole 110. In this embodiment, the liquid flexible material is Guoyuan silicone E615, and Guoyuan silicone E615 is mixed with AB skin color in a ratio of one to one. 200 ml is poured into each of the two feeding holes 110, and the volume of the mixed liquid poured is determined by the location of the tumor. When the flexible material solidifies, a metal ball is put in. The metal ball is used as a tumor model 104 to simulate the tumor. In this embodiment, the metal ball is a tungsten ball. The diameter of the metal ball is determined by the size of the tumor. In this embodiment, the diameter of the metal ball is 1 cm. Disassemble the first shell mold 11, as shown Figure 5 As shown, two cavities each filled with 200 ml of silica gel are exposed; two breathing cavity structures 30 are placed in the cavities, the disassembled first shell mold 11 is installed in the lung shell mold 10, the flexible tube 33 extends from the feeding hole 110, and E615 mixed silica gel liquid is poured into the feeding hole 110 until it is full, and then demolded after solidification to obtain the lung model 103. In other embodiments, when there are multiple tumors, after placing the two breathing cavity structures 30 in the cavity, the E615 mixed silica gel liquid is injected several times and metal balls are placed until the cavity 14 is filled, and a lung model 103 containing a tumor model 104 is formed inside the lung shell mold 10.

[0052] Please continue reading Fig.10The chest mold 40 includes four separate molds 41, and a pouring port 410 is provided at the top of the chest mold 40. The steps of forming the chest model are as follows: spread a layer of 1 cm thick white clay mud on a plane, put the prepared lung model 103 in the middle, press it down slightly to fix it, then put the rib model 102 into the lung model 103 from above, take out the flexible tube 33 from above, and finally close the four chest molds with the lung model as the center, and use clay to assist in fixing, and the flexible tube 33 extends from the two pouring ports 410 above. After the fixation is completed, introduce the 1:1 mixed Guoyuan silicone G05, fill it up, wait until it solidifies, and demold it the next day to complete the production of the simulated human chest and lung breathing model.

[0053] Simulate human chest and lung breathing model Fig.11 as well as Fig.12 As shown, it includes a chest model 101, a rib model 102, a lung model 103 and a tumor model 104. The lung model 103 is made of a flexible material, and the lung model 103 is a hollow structure and is connected to the outside through a flexible tube 33. The tumor model 104 is embedded in the lung model 103. The rib model 102 is set on the outside of the lung model 102. The chest model 101 is formed on the outside of the rib model 102, and the chest model 101 is made of a flexible material. The chest model 101 and the lung model 103 use silicone of different hardness to organically combine the lung breathing model and the chest and abdomen model, and simulate the tumor by placing a tungsten ball. The lung model 103 is inflated and deflated through the flexible tube 33, and the effect of linked breathing is achieved during the inflation and deflation process, and the position of the tumor will change continuously with breathing, so as to accurately judge the displacement change of the tumor caused by breathing during the breathing process. It solves the problem that the traditional tumor breathing model has low simulation degree, unclear effect, and cannot be actually applied.

[0054] The above embodiments only express several implementation methods of the present invention, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for ordinary technicians in this field, several modifications and improvements can be made without departing from the concept of the present invention, which are equivalent modifications and improvements made to the above embodiments based on the essential technology of the present invention, and all of them belong to the protection scope of the present invention.

Claims

1. A method for preparing a human chest and lung breathing tumor model, characterized in that: The following steps are involved: Making a lung shell mold: assembling a plurality of shell molds to form a lung shell mold, wherein a cavity is formed inside the lung shell mold; Making a breathing cavity structure: using a flexible material to form a hollow breathing cavity structure, wherein a flexible tube is provided on the breathing cavity structure, and the flexible tube is connected to the internal hollow structure; Lung model forming: according to the location of the tumor, liquid flexible material is injected into the mold cavity, and metal balls are placed after the flexible material solidifies, the metal balls are used to simulate the tumor, at least one of the shells is disassembled to open the mold cavity, two breathing cavity structures are placed in the mold cavity, and the disassembled shells are installed in the lung shell mold. According to the number and location of the tumor, liquid flexible material is continuously injected and metal balls are placed until the mold cavity is filled, and a lung model containing a tumor model is formed inside the lung shell mold; Chest model forming: the rib model is inserted into the lung model, and multiple separate molds are closed and assembled with the lung model as the center to form a chest mold. The flexible tube extends from the rib model and the chest mold, and liquid flexible material is injected into the chest mold. After curing, the chest and lung respiratory tumor model is demolded.

2. The method for making a simulated human chest and lung breathing tumor model according to claim 1, characterized in that: The specific steps for making the breathing cavity structure are: placing the inner cavity mold inside the outer cavity mold, injecting liquid flexible material between the inner cavity mold and the outer cavity mold, allowing the liquid flexible material to solidify to form a main body, taking the main body out from between the inner cavity mold and the outer cavity mold, and placing the main body into a cavity bottom sealing mold with liquid flexible material to form a sealing surface on the main body, wherein the sealing surface is provided with a connecting hole, and the flexible tube is fixed to the connecting hole.

3. The method for preparing a simulated human chest and lung breathing tumor model according to claim 1, characterized in that: The flexible material is silica gel.

4. The method for preparing a simulated human chest and lung breathing tumor model according to claim 3, characterized in that: The lung model is made of silica gel E615, the breathing cavity structure is made of silica gel E615, and the chest model is made of silica gel G05.

5. The method for making a simulated human chest and lung breathing tumor model according to claim 1, characterized in that: In the lung model forming step, the metal ball is a tungsten ball.

6. The method for making a simulated human chest and lung breathing tumor model according to claim 1, characterized in that: The method for making a simulated human chest and lung respiratory tumor model also includes obtaining human data. The step of obtaining human data is located before the step of making a lung shell mold. The step of obtaining human data specifically includes: obtaining human medical images, obtaining tumor quantity, size, and location information based on the medical images, and obtaining human lung, rib and chest size data.

7. The method for making a simulated human chest and lung breathing tumor model according to claim 6, characterized in that: In the step of making the lung shell mold, a plurality of the shell molds are made by 3D printing according to the human lung size data, and in the chest model forming step, the split mold is made by 3D printing according to the human chest data.

8. The method for making a simulated human chest and lung breathing tumor model according to claim 1, characterized in that: In the process of making the lung shell mold, there are three shell molds, which are respectively a first shell mold, a second shell mold and a third shell mold. The first shell mold and the second shell mold are assembled to form a half lung model. The first shell mold is located above the second shell mold. The first shell mold is provided with a feeding hole, which is located at the top of the first shell mold. The third shell mold is fixed to the first shell mold and the second shell mold to form the lung shell mold together.

9. A human chest and lung breathing tumor model simulated by the human chest and lung breathing tumor model manufacturing method according to any one of claims 1 to 8, characterized in that: The simulated human chest and lung breathing tumor model comprises a chest model, a rib model, a lung model and a tumor model, wherein the lung model is made of a flexible material, the lung model is a hollow structure and is connected to the outside through a flexible tube, the tumor model is embedded in the lung model, the rib model is sleeved on the outside of the lung model, the chest model is formed on the outside of the rib model, the chest model is made of a flexible material, and can simulate human breathing by inflating or deflating the flexible tube.

10. The simulated human chest and lung breathing tumor model according to claim 9, characterized in that: The lung model is made of silica gel E615, and the chest model is made of silica gel G05.

Citation Information

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