Traditional Chinese medicine formula for treating cold-cold fire-wrapping syndrome of respiratory virus infection

Abstract

The invention discloses a traditional Chinese medicine formula for treating respiratory virus infection cold-cold wrapping fire syndrome, and relates to the technical field of traditional Chinese medicine formulae, the formula comprises nine Chinese herbal medicines: radix puerariae, almond, cassia twig, gypsum, liquorice, radix bupleuri, scutellaria baicalensis, platycodon grandiflorum and raw ephedra, and the medicines are extracted and packaged through the steps of decoction, concentration, drying, powder preparation and the like. The traditional Chinese medicine formula for treating respiratory virus infection cold-wrapped fire syndrome provided by the invention can be used for effectively relieving related symptoms, improving disease prognosis and avoiding further damage to health of patients and increase of treatment cost caused by aggravation of the disease when being used for treating cold patients suffering from the respiratory virus infection early-stage cold-wrapped fire syndrome. And the traditional Chinese medicine composition is suitable for a wide range of people and can be widely popularized and applied clinically.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine formulas, and in particular to a traditional Chinese medicine formula for treating respiratory viral infection with a cold syndrome of cold enveloping fire. Background Art

[0002] Since the 1970s, the World Health Organization has found that new infectious diseases emerge almost every year around the world, among which viral diseases are the main type. The respiratory tract is the most common site of viral invasion. Among the pathogenic microorganisms of upper respiratory tract infections, 70%-80% are viruses, and about 61% are viruses in the lower respiratory tract. With the changes in the social and natural environment, and the continuous mutation of viruses, new respiratory viral infections may continue to emerge, causing great impacts on public health, social stability and the national economy. Therefore, respiratory viral infections should be given great attention.

[0003] For respiratory viral infections, early identification, early intervention, and blocking of transmission are the key to reducing severe illness and mortality. Due to their structural characteristics, common RNA viruses such as influenza virus, syncytial virus, and coronavirus will conceal their own identifiable RNA replicas after infecting the host, resulting in immune escape, which in turn causes massive viral replication and aggravates the infection. Therefore, in the early stages of infection, how to accurately identify the key links in the progression of the disease, conduct timely treatment intervention, and avoid the disease from becoming severe is the focus of preventing and treating severe respiratory viral infections. At present, clinical practice lacks sufficient attention to the early stages of respiratory viral infections, and there are no biomarkers or clinical evaluation technologies related to the severity of respiratory viral infections. At the same time, the treatment of early respiratory viral infections is mainly conventional treatment, which is usually unable to effectively relieve the patient's clinical symptoms.

[0004] Traditional Chinese medicine believes that respiratory viral infections belong to the categories of "epidemic diseases" and "exogenous febrile diseases". For the early stage of respiratory viral infections, the current consensus on relevant diagnosis and treatment plans mainly divides them into wind-cold, wind-heat, summer-dampness, qi deficiency, yang deficiency and other syndromes. However, many scholars such as Liu Qingquan and Wang Yuguang have proposed that in addition to the above common syndromes, cold-encapsulated fire syndrome is also a common syndrome of respiratory viral infections, especially in the winter and spring influenza seasons. This is a shortcoming of the current diagnosis and treatment plans for respiratory viral infections. Professor Qi Wensheng, the leader of the emergency department of Guang'anmen Hospital, combined with decades of clinical observation and treatment experience, believes that cold-encapsulated fire syndrome objectively exists in respiratory viral infections, and further proposed that cold-encapsulated fire syndrome is a specific syndrome that forms typical viral pneumonia or causes worsening of the disease in the early stage of respiratory viral infections. At the same time, it was further discovered that patients with cold-enclosing-fire syndrome could be divided into those with external cold and those with heat-toxicity based on their different constitutions and disease stages. For the first time, a treatment plan was proposed: "Those with external cold as the main symptom should be given the Chinese medicine prepared with the formula of the present invention, and those with heat-toxicity as the main symptom should be given the detoxification and clearing away heat prescription." This plan was confirmed to be definite in effectiveness and safety through clinical observation. Summary of the invention

[0005] The purpose of the present invention is to solve the above problems and provide a traditional Chinese medicine formula for treating respiratory viral infection with cold syndrome and cold-enclosed-fire syndrome.

[0006] In order to achieve the above-mentioned purpose, the technical scheme of the present invention is as follows: a traditional Chinese medicine formula for treating respiratory viral infection with cold syndrome and cold-encircled fire syndrome, wherein the traditional Chinese medicine formula is prepared from the following 9 kinds of Chinese medicinal herbs: kudzu root, apricot kernel, cassia twig, gypsum, licorice, bupleurum, scutellaria, platycodon, and raw ephedra.

[0007] Preferably, the weight ratio of each medicine in the traditional Chinese medicine formula is: 15g of Pueraria root, 10g of Apricot kernel, 10g of cinnamon twig, 30g of gypsum, 10g of liquorice, 15g of bupleurum, 10g of scutellaria, 15g of platycodon, and 15g of raw ephedra.

[0008] The present invention also provides a method for preparing the above-mentioned Chinese medicine formula, comprising the following steps:

[0009] S1. Preparation of medicinal materials: preparing medicinal materials according to the Chinese medicine formula and soaking the medicinal materials;

[0010] S2, decoction: put the soaked medicinal materials into a decoction pot, add water and decoct to obtain a medicinal solution;

[0011] S3, concentration: put the liquid medicine in a concentration pot, and continue to cook over low or medium heat until the liquid medicine is concentrated to 1 / 3 of the original volume to obtain a concentrated solution;

[0012] S4, drying: placing the concentrated liquid in an oven to dry to obtain solid particles;

[0013] S5, powder making: grinding the dried solid particles into powder;

[0014] S6. Packaging: The prepared powder is packaged into small bags according to the single dose.

[0015] The application of the above Chinese medicine formula in preparing Chinese medicine for treating, preventing or prognosing respiratory viral infection with cold syndrome and cold-encircled fire syndrome.

[0016] Compared with the prior art, this solution has the following beneficial effects:

[0017] The present invention is aimed at treating patients with early-stage cold-enclosed-fire syndrome with a partial external cold in respiratory viral infection, can effectively alleviate relevant symptoms, improve disease prognosis, and avoid further damage to the health of patients caused by aggravation of the disease and increase in treatment costs. The medicine is simple to use, suitable for a wide range of people, and can be widely promoted and applied in clinical practice. DETAILED DESCRIPTION

[0018] In order to enable those skilled in the art to better understand the solution of the present invention, the technical solution of the present invention will be further described in detail below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in the field without creative work should fall within the scope of protection of the present invention.

[0019] It should be noted that, in the absence of conflict, the embodiments and features in the embodiments of the present invention can be combined with each other. The present invention will be described in detail below in conjunction with the embodiments.

[0020] Embodiment 1:

[0021] A traditional Chinese medicine formula for treating respiratory viral infection with cold syndrome including cold-enclosed-fire syndrome, comprising: 15g of kudzu root, 10g of apricot kernel, 10g of cassia twig, 30g of gypsum, 10g of liquorice, 15g of bupleurum, 10g of scutellaria, 15g of platycodon, and 15g of raw ephedra.

[0022] The efficacy of each Chinese medicine in the above formula:

[0023] Pueraria root: sweet, pungent, cool; Functions and indications: relieves muscle and reduces fever, promotes the production of body fluid, promotes the exudation of rashes, promotes yang and stops diarrhea. It is used for exogenous fever, headache, stiff neck and back pain, thirst, thirst, measles that does not break out, heat dysentery, diarrhea; and stiff neck and pain due to hypertension.

[0024] Apricot kernel: bitter, warm; Functions and indications: expectorant, cough relieving, asthma relieving, intestine moistening. Treats exogenous cough, asthma, throat congestion, dry intestine constipation.

[0025] Cinnamon twig: pungent, sweet, warm; Functions and indications: sweating and relieving muscles, warming and unblocking meridians, assisting yang and transforming qi, balancing and descending qi. Used for colds, cold pain in the abdomen, amenorrhea due to cold blood, joint pain, phlegm and fluid retention, edema, palpitations, and running pig.

[0026] Gypsum: sweet, pungent, very cold; Functions and indications: clearing away heat and purging fire, relieving restlessness and quenching thirst. Used for exogenous febrile diseases, high fever and thirst, lung heat and cough, hyperactivity of stomach fire, headache, and toothache.

[0027] Licorice: sweet, neutral; Functions and indications: tonifying the spleen and replenishing qi, clearing away heat and detoxifying, removing phlegm and relieving cough, relieving pain, and harmonizing various medicines. It is used for spleen and stomach weakness, fatigue, palpitations and shortness of breath, cough with sputum, abdominal and limb cramps and pain, carbuncle, sore and ulcer, and relieving drug toxicity and potency.

[0028] Bupleurum: bitter, slightly cold; Functions and indications: harmonize the exterior and interior, soothe the liver, and raise yang. Used for colds and fevers, alternating colds and heat, chest and flank pain, irregular menstruation, uterine prolapse, and rectal prolapse.

[0029] Scutellaria baicalensis: bitter, cold; Functions and indications: clearing away heat and dampness, purging fire and detoxifying, stopping bleeding, and calming the fetus. It is used for damp-heat, chest tightness and nausea due to summer heat, damp-heat fullness, diarrhea, jaundice, lung heat cough, high fever and thirst, vomiting and bleeding due to blood heat, carbuncle, sore and toxicity, and restless fetus.

[0030] Platycodon grandiflorum: bitter, pungent, neutral; Functions and indications: clearing the lungs, relieving sore throat, removing phlegm, and draining pus. Used for cough with a lot of phlegm, chest tightness, sore throat, hoarseness, lung abscess with pus, and sores with pus that do not break.

[0031] Raw Ephedra: pungent, slightly bitter, warm; Functions and indications: sweating and dispelling cold, promoting lung function and relieving asthma, promoting diuresis and reducing swelling. Used for colds, chest tightness, asthma and cough, and edema caused by wind and water.

[0032] The preparation process of the above Chinese medicine formula is as follows:

[0033] S1. Preparation of medicinal materials: preparing medicinal materials according to the Chinese medicine formula and soaking the medicinal materials;

[0034] S2, decoction: put the soaked medicinal materials into a decoction pot, add water and decoct to obtain a medicinal solution;

[0035] S3, concentration: put the liquid medicine in a concentration pot, and continue to cook over low or medium heat until the liquid medicine is concentrated to 1 / 3 of the original volume to obtain a concentrated solution;

[0036] S4, drying: placing the concentrated liquid in an oven to dry to obtain solid particles;

[0037] S5, powder making: grinding the dried solid particles into powder;

[0038] S6. Packaging: The prepared powder is packaged into small bags according to the single dose.

[0039] Dosage: Take with a small amount of warm water, usually twice a day. For severe cases, take 4 times a day for a short period of time.

[0040] Embodiment 2:

[0041] Li XX, female, 36 years old. First diagnosis: Fever with body pain for 2 days. The patient had fever without obvious cause 2 days ago, accompanied by body pain, mild headache, Tmax: 39.2℃, mild sore throat, self-administered antipyretic analgesics and amoxicillin without significant improvement, influenza A (+), blood routine: LYM: 0.9×10 9 / L, no other obvious abnormalities, influenza A virus infection is considered. Current symptoms: fever, T: 38.4℃, no sweat, not much sweating, body pain, muscle aches all over the body, headache, sore throat, cough, coughing up a little white sticky sputum, general fatigue, poor appetite, sleep, and regular bowel movements. The tongue is light red, the fur is thin and greasy, the pulse is floating and slippery, and the clinical symptom score is 12 points. Five doses of the Chinese medicine prepared by the formula of the present invention were given. At the second visit, the patient's fever subsided, there was no fever, the headache and body pain were alleviated, and there was still a little cough, and the clinical symptom score was 6 points.

[0042] Table 1 Influenza symptom rating scale

[0043]

[0044] Embodiment 3:

[0045] Niu XX, male, 49 years old. First diagnosis: fever with cough for 3 days. The patient developed fever after catching a cold 3 days ago, fear of cold, Tmax: 38.6℃, accompanied by cough and sputum, no sore throat, self-medication of cold and heat-clearing granules and Xiao Chaihu granules did not improve, and then checked for influenza A (+), and blood routine was normal, considering influenza A virus infection. Current symptoms: fever, T: 38.0℃, fear of cold, sweating after taking antipyretic analgesics, occasional cough, fatigue, poor appetite, sleep, dry stool, yellow urine. The tongue is light red, the fur is thin and white, the pulse is floating and tight, and the clinical symptom score is 12 points. Five doses of Chinese medicine prepared by the formula of the present invention were given. There was no fever after taking the medicine at the second diagnosis, but there was still cough, no sputum, and no discomfort in the rest, and the clinical symptom score was 4 points.

[0046] Embodiment 4:

[0047] Jiang X, female, 28 years old. First diagnosis: Fever and headache for 2 days. The patient had fever without obvious cause 2 days ago, accompanied by headache, soreness in the whole body without pain, Tmax: 38.2℃, sore throat, cough, a little white sputum, and no obvious improvement after taking Lianhua Qingwen Capsules on her own, so she was checked for influenza A (+), blood routine: LYM: 0.6×10 9 / L, CRP: 22mg / L, no other obvious abnormalities, influenza A virus infection is considered. Current symptoms: fever, T: 38.1℃, stuffy nose, not much sweating, headache, backache, heavy legs, no sore throat, cough, cough a little white sticky sputum, general fatigue, poor appetite, sleep, bowel movements. Pale red tongue, thin white fur, floating pulse, clinical symptom score of 13 points. Five doses of the Chinese medicine prepared by the formula of the present invention were given. At the second visit, the patient's fever subsided, there was no headache, body aches were relieved, cough was relieved, and the clinical symptom score was 4 points.

[0048] Example 5

[0049] Xu XX, male, 27 years old. First visit: fever with body pain for 1 day. The patient developed fever after catching a cold 1 day ago, was afraid of cold, Tmax: 39.2℃, had pain all over the body, dry throat without sore throat, took cold medicine Lianhua Qingwen Capsule, Gankang, etc. but did not get better, checked influenza A (+), blood routine LYM: 0.82×10 9 / L, CRP: 37mg / L, no abnormalities in other tests, influenza A virus infection is considered. Current symptoms: fever, T: 38.8℃, fear of cold, sweating after taking antipyretic analgesics, temporary fever reduction, fatigue without body pain, backache, good appetite and sleep, and regular bowel movements. The tongue is light red, the fur is thin and white, the pulse is floating and tight, and the clinical symptom score is 12 points. Five doses of the Chinese medicine prepared by the formula of the present invention were given. There was no fever after taking the medicine at the second visit, the body pain was relieved, and there was a slight cough, and the clinical symptom score was 5 points.

[0050] Example 6

[0051] Du X, female, 36 years old. First diagnosis: fever with cough for 3 days. The patient had fever without obvious cause 3 days ago, fear of cold, Tmax: 37.8℃, cough without sputum, nasal congestion, dry mouth, no sore throat, self-medication with Jinhua Qinggan Granules, Baijiahei and other medicines did not improve, check for influenza A (+), blood routine was normal, and influenza A virus infection was considered. Current symptoms: fever, T: 37.8℃, cough without sputum, nasal congestion, dry mouth, no sore throat, no body pain, fatigue, no headache, good appetite and sleep, two bowel movements, clinical symptom score of 7 points. Five doses of Chinese medicine prepared by the formula of the present invention were given. There was no fever at the second visit, nasal congestion was relieved, cough with a little white sputum, and clinical symptom score of 3 points.

[0052] The above specific embodiments are merely explanations of the present invention and are not limitations of the present invention. After reading this specification, those skilled in the art may make modifications to the embodiments without any creative contribution as needed. However, such modifications are protected by the patent law as long as they are within the scope of the claims of the present invention.

Claims

1. A Chinese medicine formula for treating respiratory viral infection with cold syndrome characterized by: The Chinese medicine formula is prepared from the following 9 kinds of Chinese medicinal herbs: Pueraria root, apricot kernel, cassia twig, gypsum, liquorice, bupleurum, scutellaria, platycodon grandiflorum, and raw ephedra.

2. A Chinese medicine formula for treating respiratory viral infection with cold syndrome and cold-enclosed fire syndrome according to claim 1, characterized in that: The weight proportions of the various herbs in the traditional Chinese medicine formula are as follows: 15g of kudzu root, 10g of apricot kernel, 10g of cassia twig, 30g of gypsum, 10g of liquorice, 15g of bupleurum, 10g of scutellaria, 15g of platycodon grandiflorum, and 15g of raw ephedra.

3. The method for preparing the Chinese medicine formula according to claim 2, characterized in that: The following steps are involved: S1. Preparation of medicinal materials: preparing medicinal materials according to the Chinese medicine formula and soaking the medicinal materials; S2, decoction: put the soaked medicinal materials into a decoction pot, add water and decoct to obtain a medicinal solution; S3, concentration: put the liquid medicine in a concentration pot, and continue to cook over low or medium heat until the liquid medicine is concentrated to 1 / 3 of the original volume to obtain a concentrated solution; S4, drying: placing the concentrated liquid in an oven and drying it to obtain solid particles; S5, powder making: grinding the dried solid particles into powder; S6. Packaging: The prepared powder is packaged into small bags according to the single dose.

4. Use of the Chinese medicine formula according to claim 1 or 2 in the preparation of a Chinese medicine for the treatment, prognosis or diagnosis of respiratory viral infection with cold syndrome.

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