Micro-needle percussion device and method suitable for in-vivo minimally invasive treatment

Abstract

The invention discloses a microneedle percussion device and method suitable for in-vivo minimally invasive treatment, and belongs to the technical field of medical instruments, the microneedle percussion device comprises a percussion tube body, a percussion column, two pull rod handles, a trigger piece, a pressurization end cover, a protection sleeve and a microneedle adapter, guide sliding grooves are symmetrically formed in the two sides of the percussion tube body, and a trigger limiting hole is formed in the side wall of the percussion tube body; the percussion column comprises a percussion column body and a percussion extension rod, and a pull rod mounting groove and a trigger mounting groove are formed in the side wall of the percussion column body; the pull rod handle is slidably connected into the guide sliding groove and connected into the pull rod mounting groove. The triggering piece is connected in the triggering mounting groove and can be clamped in the triggering limiting hole; an elastic piece supported at the top end of the percussion column is arranged in the pressurizing end cover; the protective sleeve is correspondingly connected to the lower end of the percussion tube body; and the microneedle adapter is connected in the protective sleeve in a sliding manner and is connected with the lower end of the percussion extension rod. The micro-needle patch is percussed and punctured into the skin or deep tissue by controlling the percussion column to push the micro-needle adapter downwards, and precise implantation of the micro-needle patch is completed.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a microneedle firing device and method suitable for minimally invasive treatment in vivo. Background Art

[0002] As an emerging drug delivery and treatment method, microneedle technology has made significant progress in the biomedical field in recent years. Compared with traditional syringes, microneedles penetrate biological barriers such as the skin in a minimally invasive or non-invasive way to deliver drugs or other active ingredients directly into the body. This technology can not only significantly improve the bioavailability of drugs, but also reduce the pain and discomfort of patients. It is especially suitable for various clinical application scenarios such as vaccination, skin care, local drug delivery, and chronic disease management.

[0003] Although microneedle technology has broad application prospects, it still faces many challenges in practical applications.

[0004] (I) Existing microneedle firing devices mainly rely on manual operation, and the microneedles are inserted into the skin by applying a certain external force. In actual operation, there are the following technical deficiencies: (1) Manual firing is difficult to control accurately. The manual microneedle firing device relies on the strength of the operator, which makes the force, speed and penetration depth of each operation inconsistent, which easily leads to differences in drug delivery effects. Especially in scenarios that require multiple operations or large-scale vaccination, manual operation is not only inefficient, but may also cause the microneedles to be inserted too shallowly, affecting the absorption of the drug; or inserted too deeply, causing damage to the patient's skin or tissue. (2) Although there are some automated microneedle firing devices on the market, these devices are often complex in structure, have high manufacturing costs, and are insufficient in convenience and portability, which limits their promotion and application in scenarios such as large-scale vaccination and home treatment.

[0005] (II) With the continuous development of microneedle technology, many new types of microneedles have emerged, such as solid microneedles, coated microneedles, hollow microneedles, soluble microneedles, hydrogel microneedles, etc. These new types of microneedles have different characteristics and uses, but the dedicated firing devices for them on the market are not yet mature, making the development of firing devices specifically suitable for them an important technical challenge in the application of microneedle technology.

[0006] (III) Microneedle technology directly penetrates the skin and contacts the body's tissues during use, so a sterile environment during operation is crucial. However, existing microneedle firing devices face the following technical problems in aseptic operation: (1) It is difficult to maintain sterility during operation. When operating the microneedle firing device, the device is prone to direct contact with the operator's hands or the patient's skin, increasing the risk of contamination. Existing sterile protection measures cannot completely solve this problem. (2) Some existing firing devices achieve aseptic operation through complex sealing or disposable use, but this type of design increases manufacturing costs and operational complexity, affecting feasibility in clinical applications.

[0007] (IV) A key issue in the design of microneedle firing devices is how to achieve a balance between the firing force and the penetration depth of the microneedle. If the firing force is too small, the microneedle will not be able to effectively penetrate the skin, affecting drug delivery; while if the firing force is too large, it may damage the skin or deep tissue and cause pain. How to achieve precise and controllable firing force design to ensure that the microneedle can stably penetrate the target tissue under different skin thicknesses and physiological conditions without causing excessive tissue damage is the core technical problem in the design of microneedle devices.

[0008] (V) Current microneedle technology and firing devices are mainly used for drug delivery on the surface of the skin, but have not yet been used for drug delivery to deep organs. The structure of deep organs is complex, and the guidance, positioning and control of the puncture depth of the microneedle after penetrating the skin require more sophisticated design. How to achieve accurate entry of the microneedle into the deep organs without damaging the surrounding tissues is a difficult problem that has not yet been overcome by existing technologies. The development of a microneedle firing device suitable for drug delivery to deep organs will provide a new technical path for the treatment of diseases such as tumors and cardiovascular diseases.

[0009] (VI) Existing microneedle firing devices are not portable and adaptable to multiple scenarios, especially in scenarios such as vaccination in remote areas, home treatment or long-term patient management, where large and complex devices are not suitable. Therefore, developing a microneedle firing device that is portable, adaptable to multiple clinical needs and can be used in a sterile environment will greatly enhance its application potential in various medical scenarios.

[0010] Based on the above problems, the market demand for microneedle firing devices is increasing, especially in the areas of aseptic operation, deep organ drug delivery, and automated precision control. Technological breakthroughs will further promote the widespread application of microneedle technology in clinical and biomedical fields. Innovative microneedle firing devices will be able to meet the drug delivery needs in different scenarios, improve the efficiency of clinical operations, reduce patient pain, and provide more technical solutions for the treatment of deep tissues and organs in the future. Summary of the invention

[0011] Technical problems solved: In response to the technical problems existing in the background technology, the present invention provides a more accurate, reliable and convenient microneedle firing device to promote the widespread application of microneedle technology in the field of drug delivery.

[0012] Technical solution: The present invention provides a microneedle firing device suitable for minimally invasive treatment in vivo, the microneedle firing device comprising: A firing tube body, wherein the firing tube body is provided with a receiving cavity with an open top and a correspondingly open limiting cavity arranged at the lower end of the receiving cavity, wherein the inner diameter of the limiting cavity is smaller than the inner diameter of the receiving cavity; guide grooves communicating with the receiving cavity are symmetrically arranged on both sides of the firing tube body along its length direction, and a trigger limiting hole communicating with the receiving cavity is arranged on a side wall of the firing tube body different from the side of the guide groove; The firing column comprises a firing column body adapted to the inner diameter of the accommodating cavity, and a firing extension rod adapted to the inner diameter of the limiting cavity is coaxially arranged at the lower end of the firing column body; two pull rod installation grooves and a trigger installation groove penetrating the diameter of the firing column body are respectively arranged on the upper and lower side walls of the firing column body; Two pull rod handles, the pull rod handles are correspondingly slidably connected in the guide grooves, and the inner ends of the pull rod handles are connected in the pull rod mounting grooves of the firing column; A trigger member, the trigger member is correspondingly connected in the trigger installation groove, and one end of the trigger member is provided with an elastic protrusion, and the elastic protrusion can be correspondingly engaged in the trigger limit hole or disengaged from the trigger limit hole; A pressurized end cap, the pressurized end cap is correspondingly connected to the top of the firing tube body, and an elastic member correspondingly connected to the top of the firing column is arranged inside the pressurized end cap, and the elastic member provides driving force for the firing column; A protective sleeve, the protective sleeve is correspondingly connected to the open end of the limiting cavity of the firing tube body, and the lower end of the firing extension rod is slidably connected in the protective sleeve; A microneedle adapter, wherein the microneedle adapter is slidably connected in the protective sleeve, and the top end of the microneedle adapter is fixedly connected to the lower end of the firing extension rod; Among them, releasing the elastic member can drive the firing column to move downward along the accommodating cavity, and the firing column carries the microneedle adapter and fires downward to complete the implantation of the microneedle patch.

[0013] Preferably, an external threaded area is provided at the top of the firing tube body, and an internal threaded area adapted to the external threaded area is provided on the inner wall of the pressurized end cover; a scale for measuring the screw-in depth of the pressurized end cover is provided at the connection between the firing tube body and the pressurized end cover.

[0014] Preferably, a first fixing hole and a second fixing hole are provided on the side wall of the lower end of the firing tube body at a vertical angle along the radial direction, and fastening screws for fixing the protective sleeve are provided in the first fixing hole and the second fixing hole.

[0015] Preferably, a spring connection end for connecting an elastic member is provided at the top end of the firing column; and the elastic member is a spring element of different types.

[0016] Preferably, the pull rod installation groove and the trigger installation groove are through holes vertically arranged in the radial direction of the firing column, and the pull rod installation groove and the trigger installation groove are separated and arranged up and down.

[0017] Preferably, a mounting countersunk hole is provided at the bottom end of the firing extension rod; The microneedle adapter comprises an adapter column and an adapter connecting column correspondingly arranged at the center of the top end of the adapter column, wherein the adapter connecting column is correspondingly connected in the mounting countersunk hole; a limiting column is relatively arranged in the circumferential direction of the bottom end of the adapter column.

[0018] Preferably, one end of the pull rod handle is provided with a threaded connecting rod threadedly connected to the pull rod mounting groove.

[0019] Preferably, the trigger member is a spring plunger cylindrical head, which is threadedly connected in the trigger mounting groove, and its cylindrical head matches the trigger limit hole on the side wall of the firing tube body.

[0020] Preferably, the protective sleeve is a disposable transparent material piece.

[0021] The present invention also discloses a firing method of the microneedle firing device, and the firing method comprises the following steps: Step 1: Select a suitable type of microneedle patch according to the surgical site, attach a sticky substance to the back of the microneedle patch, and fix it to the bottom of the microneedle adapter to complete the fixed installation of the microneedle patch; Step 2: Select a protective sleeve of appropriate length, so that the microneedle adapter and the microneedle patch at the lower end thereof are stored in the protective sleeve when the firing column is in a ready-to-fire state, and the lower end of the firing extension rod extends out of the protective sleeve after the firing column is fired; insert the protective sleeve into the open end of the limiting cavity of the firing tube body and fix it with a fastening screw; Step 3: Press the cylindrical head of the spring plunger so that the cylindrical head is out of contact with the trigger limit hole on the side wall of the firing tube body, relax the restriction on the elastic member, and under the drive of the elastic member, the firing column slides downward along the accommodating cavity, driving the firing extension rod to pass through the limit cavity and extend from the lower end of the protective sleeve; Step 4: The microneedle adapter with the microneedle patch installed is fixedly connected to the lower end of the firing extension rod, and the pull rod handle is pushed to move upward along the guide groove and drive the firing column to move upward along the accommodating cavity until the cylindrical head of the spring plunger is stuck in the trigger limit hole of the side wall of the firing tube body. During the retraction of the firing column, the microneedle adapter and its microneedle patch at its lower end are driven to retract into the protective sleeve; Step 5: Rotate the connection distance between the pressurized end cap and the firing tube body according to the needs, and adjust the compression amount of the elastic member to the appropriate force, thus completing the initial setting of the microneedle firing device; Step 6: When in use, select a suitable area and move the protective sleeve to a suitable position. Press the cylindrical head of the spring plunger to disengage from the trigger limit hole on the side wall of the firing tube to relax the restriction on the firing column. The firing column pops out along the accommodating cavity under the elastic force of the elastic member, driving the microneedle adapter and its microneedle patch at its lower end to extend out of the protective sleeve. The microneedle patch is accurately inserted into the deep of the skin, tissue or organ. Slightly rotate the microneedle firing device to separate the microneedle adapter from the microneedle, and the microneedle patch implantation is completed.

[0022] Compared with the prior art, the present invention has the following beneficial effects: 1. The microneedle firing device of the present invention can manually control the firing column to push the microneedle adapter downward to squeeze the microneedle patch downward to pierce the skin or deep tissue, thereby completing the precise implantation of the microneedle patch; 2. The microneedle firing device has a simple structure and low cost. Its structural components can be made of metal, alloy or hard plastic according to the needs. It can be used once or repeatedly according to the function of the structural components, and has a wide range of application scenarios; 3. The firing column slides downward and is driven to fire by the elastic force of the elastic member. The downward firing force of the elastic member can be adjusted by adjusting the height of the pressurized end cover. When the pressurized end cover rotates downward, the compression of the elastic member increases, and the firing force of the firing column is greater at this time; if the pressurized end cover rotates upward, the compression of the elastic member decreases, and the firing force of the firing column decreases; the pull rod handle limits the position of the firing column in the guide groove of the firing tube body. After the position of the firing column is adjusted to the right position, the trigger member can be used to release or lock the limit of the firing column, and the firing column can be fired under the elastic force of the elastic member; 4. The protective sleeve can adapt to the depth from the body surface to the internal organs, and complete the deep firing and implantation of microneedle patches in the tissues or organs of the body; 5. The microneedle firing device has a simple structure and can be easily disassembled and sterilized by high pressure, which is convenient for aseptic operation; 6. The specific size of the microneedle firing device can be enlarged or reduced in proportion to the shape and size of the microneedle patch to be fired, and is not intended to limit the scope of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 A schematic diagram of the three-dimensional structure of a microneedle firing device according to an embodiment of the present invention; Figure 2 for Figure 1 Side view of the structure of the microneedle firing device; Figure 3 for Figure 2A cross-sectional view of the microneedle firing device along the AA axis; Figure 4 for Figure 1 Schematic diagram of the three-dimensional structure of the middle firing tube body; Figure 5 for Figure 4 The front view of the middle firing tube structure; Figure 6 for Figure 5 A cross-sectional view of the firing tube body in the BB direction; Figure 7 for Figure 1 Axial structural section view of the middle pressure end cover; Figure 8 for Figure 1 Schematic diagram of the structure of the middle protective casing; Fig. 9 for Figure 1 Schematic diagram of the middle pull rod handle structure; Fig.10 for Figure 3 The front view of the middle firing column and the elastic member structure; Fig.11 for Figure 3 Front view of the microneedle adapter structure; Fig.12 for Fig.11 Bottom view of the microneedle adapter structure; Fig.13 for Fig.11 Schematic diagram of the enlarged structure of the microneedle adapter at location E.

[0024] Attached figure numbers: 100, microneedle firing device; 1, firing tube body; 101, guide groove; 102, trigger limit hole; 103, first fixing hole; 104, second fixing hole; 105, external thread area; 106, accommodating cavity; 107, limit cavity; 2, pressurized end cover; 201, internal thread area; 3, protective sleeve; 4, pull rod handle; 401, threaded connecting rod; 5, scale; 6, trigger member; 7, firing column; 701, firing column; 702, spring connecting end; 703, pull rod mounting groove; 704, trigger mounting groove; 705, firing extension rod; 706, mounting countersunk hole; 8, elastic member; 9, microneedle adapter; 901, adapter column; 902, adapter connecting column; 903, limit column. DETAILED DESCRIPTION

[0025] To make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the following will be combined with the attached Figures 1 to 13The technical solutions of the embodiments of the present invention are described clearly and completely. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the described embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field belong to the scope of protection of the present invention.

[0026] Example 1: Figures 1 to 3 As shown, a microneedle firing device suitable for minimally invasive treatment in vivo of the present invention, the microneedle firing device 100 includes a firing tube body 1, a firing column 7, two pull rod handles 4, a trigger member 6, a pressurized end cover 2, a protective sleeve 3 and a microneedle adapter 9.

[0027] like Figures 4 to 6 As shown, the firing tube body 1 is provided with a receiving cavity 106 with an open top and a correspondingly open limiting cavity 107 arranged at the lower end of the receiving cavity 106, and the inner diameter of the limiting cavity 107 is smaller than the inner diameter of the receiving cavity 106. The firing tube body 1 is symmetrically provided with guide grooves 101 connected to the receiving cavity 106 along its length direction on both sides, and a trigger limiting hole 102 connected to the receiving cavity 106 is provided on the side wall of the firing tube body 1 different from the guide groove 101. The position of the trigger limiting hole 102 is set in a direction perpendicular to the line connecting the two guide grooves 101, and is used to limit the position of the trigger member 6.

[0028] like Figures 9-10 As shown, the firing column 7 includes a firing column 701 adapted to the inner diameter of the accommodating cavity 106, and a spring connection end 702 for connecting the elastic member 8 is arranged at the top of the firing column 7. The elastic member 8 can use different types of spring elements to provide elastic driving force for the firing column 7. A firing extension rod 705 adapted to the inner diameter of the limiting cavity 107 is coaxially arranged at the lower end of the firing column 701. The firing column 701 is slidably connected in the accommodating cavity 106, and the firing extension rod 705 is slidably connected in the limiting cavity 107. The limiting cavity 107 can limit the sliding end position of the firing column 7. The side wall of the firing column 701 is provided with two rod mounting grooves 703 and trigger mounting grooves 704 that penetrate the diameter of the firing column; specifically, the rod mounting grooves 703 and trigger mounting grooves 704 are through holes vertically arranged in the radial direction of the firing column 701, and the rod mounting grooves 703 and trigger mounting grooves 704 are separated from each other up and down, and a threaded connecting rod 401 is provided at one end of the rod handle 4, and the screw connecting rods of the two rod handles 4 pass through the corresponding guide grooves 101 and are correspondingly connected in the rod mounting grooves 703, so as to facilitate driving the firing column 7 to move forward and backward along the accommodating cavity 106 through the rod handle 4. A mounting countersunk hole 706 is provided at the bottom end of the firing extension rod 705, and the mounting countersunk hole 706 can meet the fixed connection of the microneedle adapter 9.

[0029] like Figure 2~3As shown, the trigger member 6 is correspondingly connected in the trigger mounting groove 704, and one end thereof is provided with an elastic protrusion, which can be correspondingly engaged in the trigger limit hole 102 or disengaged from the trigger limit hole 102. Specifically, the trigger member 6 is a spring plunger cylindrical head, which is threadedly connected in the trigger mounting groove 704, and its cylindrical head matches the trigger limit hole 102 on the side wall of the firing tube body 1. By squeezing the cylindrical head, it can be disengaged from the trigger limit hole 102 to release the position limitation of the firing column 7, so that the elastic member 8 can eject the firing column 7 along the accommodating cavity 106.

[0030] like Figures 2~5 and Figure 7 As shown, the pressurized end cap 2 is correspondingly connected to the top of the firing tube body 1, and an elastic member 8 correspondingly connected to the top of the firing column 701 is arranged inside the pressurized end cap 2, and the elastic member 8 provides driving force for the firing column 7. Specifically, an external threaded area 105 is arranged at the top of the firing tube body 1, and an internal threaded area 201 adapted to the external threaded area 105 is arranged on the inner wall of the pressurized end cap 2. By screwing the pressurized end cap 2 in or out, the connection distance between the pressurized end cap 2 and the firing tube body 1 is adjusted, thereby realizing the adjustment of the compression amount of the elastic member. A scale 5 for measuring the screw-in depth of the pressurized end cap 2 is arranged at the connection between the firing tube body 1 and the pressurized end cap 2, so that it is convenient to adjust the compression amount of the elastic member 8 by observing the scale 5, and provide different elastic forces for the microneedle patch to be implanted.

[0031] like Figure 3 and Figure 8 As shown, the protective sleeve 3 is correspondingly connected to the open end of the limiting cavity 107 of the firing tube body 1, and the lower end of the firing extension rod 705 is slidably connected in the protective sleeve 3. The first fixing hole 103 and the second fixing hole 104 are arranged on the side wall of the lower end of the firing tube body 1 at a vertical angle along the radial direction, and the fixing holes are provided with fastening screws for fixing the protective sleeve 3. The upper end of the protective sleeve 3 is inserted into the open end of the limiting cavity 107 of the firing tube body 1, and then fixed by fastening screws. The protective sleeve 3 can be made of a disposable transparent material, which is convenient for observing the connection status of the microneedle adapter 9 and the microneedle patch therein; during the microneedle firing process, the protective sleeve 3 can protect the microneedle patch carried by the firing column 7 without other interference to successfully complete the microneedle insertion, and its size can be adapted according to the size of the microneedle patch to be inserted.

[0032] like Figures 10 to 13As shown, the microneedle adapter 9 is slidably connected in the protective sleeve 3, and its top end is fixedly connected to the lower end of the firing extension rod 705; the microneedle adapter 9 includes an adapter column 901 and an adapter connecting column 902 correspondingly arranged at the top center of the adapter column 901, and the adapter connecting column 902 is correspondingly connected in the mounting countersunk hole 706. The bottom end of the adapter column 901 is circumferentially relatively provided with a limiting column 903, and the two limiting columns 903 can be fixed and clamped to the microneedle patch. The limiting column 903 can adjust the size according to the microneedle patch and clamp the microneedle patch. A small amount of double-sided tape can be adhered to the bottom of the limiting column 903 to temporarily adhere the microneedle patch to prevent the microneedle patch from accidentally falling off before firing, thereby completing the installation of the microneedle patch. After the microneedle patch is installed, the microneedle firing device can be triggered, and the microneedle patch is accurately inserted into the skin, tissue or deep into the internal organs. The microneedle firing device can be separated from the microneedle patch by slightly rotating it. The microneedle adapter 9 can adapt the shape of the connecting column 902 according to the shape and characteristics of different microneedle patches. Microneedle patches can be selected from solid microneedles, coated microneedles, hollow microneedles, soluble microneedles, hydrogel microneedles, etc. In addition, the shape and length of the firing extension column and the protective sleeve 3 can also be adjusted according to the adaptation of different microneedle patches and the application to the skin surface or deep tissue organs. The firing extension column, the microneedle adapter 9 and the protective sleeve 3 can be adapted to realize the insertion of microneedle patches of various heights in the skin, tissues or organs or other application scenarios.

[0033] The structural elements used in the microneedle firing device of the present invention can be made of metal, alloy or hard plastic according to needs. It has a simple structure and low cost. It can be used once or repeatedly according to the function of the structural components and has a wide range of usage scenarios.

[0034] Embodiment 2: The present invention also discloses a firing method of a microneedle firing device, the firing method comprising the following steps: (i) Select a microneedle patch of appropriate type according to the surgical site, attach a sticky substance to the back of the microneedle patch, and fix it to the bottom of the microneedle adapter 9 to complete the fixed installation of the microneedle patch.

[0035] (ii) Select a protective sleeve 3 of appropriate length to ensure that the microneedle adapter 9 and the microneedle patch at the lower end are accommodated in the protective sleeve 3 when the firing column 7 is in the ready-to-fire state, and the lower end of the firing extension rod 705 extends out of the protective sleeve 3 after the firing column 7 is fired; insert the protective sleeve 3 into the open end of the limiting cavity 107 of the firing tube body 1 and fix it with a fastening screw.

[0036] (3) Pressing the cylindrical head of the spring plunger causes the cylindrical head to disengage from the trigger limit hole 102 on the side wall of the firing tube body 1, thereby releasing the restriction on the elastic member 8 and, driven by the elastic member 8, the firing column 7 slides downward along the accommodating cavity 106, driving the firing extension rod 705 to pass through the limit cavity 107 and extend from the lower end of the protective sleeve 3.

[0037] (iv) The microneedle adapter 9 equipped with the microneedle patch is fixedly connected to the lower end of the firing extension rod 705, and the pull rod handle 4 is pushed to move upward along the guide groove 101 and drive the firing column 7 to move upward along the accommodating cavity 106 until the cylindrical head of the spring plunger is stuck in the trigger limit hole 102 on the side wall of the firing tube body 1. During the retraction process of the firing column 7, the microneedle adapter 9 and the microneedle patch at its lower end are driven to retract into the protective sleeve 3.

[0038] (V) According to the requirements, the connection distance between the pressurizing end cap 2 and the firing tube 1 is rotated, and the compression amount of the elastic member 8 is adjusted to a suitable force, and the initial setting of the microneedle firing device is completed. It should be noted that the adjustment of the position of the pressurizing end cap 2 can be adjusted at an appropriate time and is not limited to this step.

[0039] (six) When in use, select a suitable area and move the protective sleeve 3 to a suitable surgical position, press the cylindrical head of the spring plunger to disengage the trigger limit hole 102 on the side wall of the firing tube body 1 to relax the restriction on the firing column 7, and the firing column 7 pops out along the accommodating cavity 106 under the elastic force of the elastic member 8, driving the microneedle adapter 9 and its microneedle patch at its lower end to extend out of the protective sleeve 3, and the microneedle patch is accurately inserted into the deep of the skin, tissue or internal organs, and the microneedle firing device is slightly rotated to separate the microneedle adapter 9 from the microneedle, thus completing the implantation of the microneedle patch.

[0040] The above are preferred embodiments of the present invention. It should be pointed out that, for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. A microneedle firing device suitable for minimally invasive treatment in vivo, characterized in that: The microneedle firing device (100) comprises: A firing tube body (1), wherein the firing tube body (1) is provided with a receiving cavity (106) with an open top and a correspondingly open limiting cavity (107) arranged at the lower end of the receiving cavity (106), wherein the inner diameter of the limiting cavity (107) is smaller than the inner diameter of the receiving cavity (106); guide grooves (101) communicating with the receiving cavity (106) are symmetrically arranged on both sides of the firing tube body (1) along its length direction, and a trigger limiting hole (102) communicating with the receiving cavity (106) is arranged on a side of the side wall of the firing tube body (1) different from the guide groove (101); A firing column (7), the firing column (7) comprising a firing column (701) adapted to the inner diameter of the accommodating cavity (106), a firing extension rod (705) adapted to the inner diameter of the limiting cavity (107) being coaxially arranged at the lower end of the firing column (701); two pull rod installation grooves (703) and a trigger installation groove (704) penetrating the diameter of the firing column being arranged on the upper and lower side walls of the firing column (701); Two pull rod handles (4), the pull rod handles (4) are correspondingly slidably connected in the guide groove (101), and the inner ends thereof are connected in the pull rod mounting groove (703) of the firing column (7); A trigger member (6), the trigger member (6) being correspondingly connected in the trigger mounting groove (704), and having one end provided with an elastic protrusion, the elastic protrusion being able to be correspondingly engaged in the trigger limiting hole (102) or being disengaged from the trigger limiting hole (102); A pressurizing end cover (2), the pressurizing end cover (2) being correspondingly connected to the top end of the firing tube body (1), and an elastic member (8) being correspondingly connected to the top end of the firing column (701) is arranged inside the pressurizing end cover (2), and the elastic member (8) provides a driving force for the firing column (7); A protective sleeve (3), the protective sleeve (3) being correspondingly connected to the open end of the limiting cavity (107) of the firing tube body (1), and the lower end of the firing extension rod (705) being slidably connected in the protective sleeve (3); A microneedle adapter (9), wherein the microneedle adapter (9) is slidably connected in the protective sleeve (3), and the top end of the microneedle adapter (9) is fixedly connected to the lower end of the firing extension rod (705); The elastic member (8) is released to drive the firing column (7) to move downward along the accommodating cavity (106), and the firing column (7) carries the microneedle adapter (9) and fires downward to complete the implantation of the microneedle patch.

2. The microneedle firing device suitable for minimally invasive treatment in vivo according to claim 1, characterized in that: The firing tube body (1) is provided with an external threaded area (105) at the top end thereof, and the inner wall of the pressurizing end cover (2) is provided with an internal threaded area (201) adapted to the external threaded area (105); a scale (5) for measuring the screw-in depth of the pressurizing end cover (2) is provided at the connection between the firing tube body (1) and the pressurizing end cover (2).

3. The microneedle firing device suitable for minimally invasive treatment in vivo according to claim 2, characterized in that: A first fixing hole (103) and a second fixing hole (104) are provided on the side wall of the lower end of the firing tube body (1) at a vertical angle along the radial direction, and fastening screws for fixing the protective sleeve (3) are provided in the first fixing hole (103) and the second fixing hole (104).

4. The microneedle firing device suitable for minimally invasive treatment in vivo according to any one of claims 1 to 3, characterized in that: The firing column (7) has a spring connection end (702) at the top end thereof for connection with an elastic member (8); the elastic member (8) is a spring element of a different type.

5. The microneedle firing device suitable for minimally invasive treatment in vivo according to claim 4, characterized in that: The pull rod installation groove (703) and the trigger installation groove (704) are through holes vertically arranged in the radial direction of the firing column (701), and the pull rod installation groove (703) and the trigger installation groove (704) are separated and arranged up and down.

6. The microneedle firing device suitable for minimally invasive treatment in vivo according to claim 4, characterized in that: The bottom end of the firing extension rod (705) is provided with a mounting countersunk hole (706); The microneedle adapter (9) comprises an adapter column (901) and an adapter connecting column (902) correspondingly arranged at the center of the top end of the adapter column (901), and the adapter connecting column (902) is correspondingly connected in the mounting countersunk hole (706); and a limiting column (903) is relatively arranged in the circumferential direction of the bottom end of the adapter column (901).

7. The microneedle firing device suitable for minimally invasive treatment in vivo according to claim 4, characterized in that: One end of the pull rod handle (4) is provided with a threaded connecting rod (401) threadedly connected to the pull rod installation groove (703).

8. The microneedle firing device suitable for minimally invasive treatment in vivo according to claim 6, characterized in that: The trigger member (6) is a spring plunger cylindrical head, which is threadedly connected in the trigger mounting groove (704), and its cylindrical head matches the trigger limit hole (102) on the side wall of the firing tube body (1).

9. The microneedle firing device suitable for minimally invasive treatment in vivo according to claim 4, characterized in that: The protective sleeve (3) is a disposable transparent material piece.

10. A firing method of the microneedle firing device according to claim 8, characterized in that: The firing method comprises the following steps: Step 1: Select a microneedle patch of appropriate size according to the surgical site, attach a sticky substance to the back of the microneedle patch, and fix it to the bottom of the microneedle adapter (9) to complete the fixed installation of the microneedle patch; Step 2: Select a protective sleeve (3) of suitable length, so that the microneedle adapter (9) and the microneedle patch at its lower end are stored in the protective sleeve (3) when the firing column (7) is in a firing state, and the lower end of the firing extension rod (705) extends out of the protective sleeve (3) after the firing column (7) is fired; insert the protective sleeve (3) into the open end of the limiting cavity (107) of the firing tube body (1) and fix it with a fastening screw; Step 3: Press the cylindrical head of the spring plunger so that the cylindrical head is out of contact with the trigger limit hole (102) on the side wall of the firing tube body (1), relax the restriction on the elastic member (8), and under the drive of the elastic member (8), the firing column (7) slides downward along the accommodating cavity (106) to drive the firing extension rod (705) to pass through the limit cavity (107) and extend from the lower end of the protective sleeve (3); Step 4: The microneedle adapter (9) equipped with the microneedle patch is fixedly connected to the lower end of the firing extension rod (705), and the pull rod handle (4) is pushed to move upward along the guide groove (101) and drive the firing column (7) to move upward along the accommodating cavity (106) until the cylindrical head of the spring plunger is stuck in the trigger limit hole (102) on the side wall of the firing tube body (1). During the retraction process of the firing column (7), the microneedle adapter (9) and the microneedle patch at its lower end are driven to retract into the protective sleeve (3); Step 5: Rotate the connection distance between the pressurizing end cap (2) and the firing tube body (1) as required, and adjust the compression amount of the elastic member (8) to a suitable force, thereby completing the initial setting of the microneedle firing device; Step 6: When in use, select a suitable area and move the protective sleeve (3) to a suitable position, press the cylindrical head of the spring plunger to disengage the trigger limit hole (102) on the side wall of the firing tube body (1) to loosen the restriction on the firing column (7), and the firing column (7) is ejected along the accommodating cavity (106) under the elastic force of the elastic member (8), driving the microneedle adapter (9) and the microneedle patch at its lower end to extend out of the protective sleeve (3), and the microneedle patch is accurately inserted into the deep of the skin, tissue or internal organs, and the microneedle firing device is slightly rotated to separate the microneedle adapter (9) from the microneedle, thus completing the implantation of the microneedle patch.

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