Chemical spectrum inspection automatic assembly line device capable of realizing quantitative liquid dropping

Abstract

The invention relates to a chemical spectrum inspection automatic assembly line device capable of realizing quantitative liquid dropping, which can quantitatively control the liquid dropping amount to realize automatic detection of chemical reaction and fluorescence spectrum, save manpower participation and solve personnel errors possibly occurring in the automatic control and detection process. The automatic titration system adopts an assembly line structure design, realizes automatic titration of a detection test tube, adopts a PLC to realize automatic control of the automatic titration device, and after receiving a test tube positioning confirmation signal of a photoelectric sensor, the PLC controls a mechanical arm to reach a designated position and triggers a liquid adding controller of the automatic titration device to carry out closed-loop titration control on the test tube. And detecting reagent components in the test tube by adopting a chemical spectrum analysis method. Along with the conveying of the conveying belt, the test tubes successively reach a specified titration position, and the synchronization of detection and chemical reaction is realized by adopting a chemical spectrum analyzer. And if the detected reagent does not meet the ideal reagent requirement, the chemical spectrum analyzer transmits the signal to the PLC, and the PLC stores the identity number of the test tube and enables the alarm to give an alarm.

Description

Technical Field

[0001] The invention discloses an automated production line device capable of realizing chemical spectrum inspection of quantitative droplets. Background Art

[0002] Titration analysis is traditionally widely used in the pharmaceutical industry and is one of the standard analytical methods for simple, rapid, repeatable and accurate analysis of active pharmaceutical ingredients and their raw materials. Automatic titrator is a precise electrochemical analyzer that can not only save reagents, reduce liquid waste, and improve quantitative accuracy, but also is more convenient to use and has significantly better performance than traditional burettes. With the continuous improvement of the level of production automation, analysis and detection methods must also be automated and rapid. In view of production practice, it is crucial to develop a multifunctional automatic titrator for rapid and automatic analysis in the chemical industry. Design a chemical titration instrument that can control titration, which can realize automatic detection, save human participation, and solve the possible human errors in the process of automatic control and detection. At present, although automatic detection technology is developing rapidly, there is still a lot of room for improvement in automatic titration detection. In order to save manpower, material resources, and financial resources to a greater extent, and to complete various production and life activities more economically and effectively, the present invention studies a more perfect transformation design based on the current titration detection equipment, and adopts a combination of potentiometric titration and chemical spectral analysis to more accurately complete automatic titration, automatically detect the titration end point, and more accurately reflect the titration detection results. Summary of the invention

[0003] The present invention provides an automated production line device for chemical spectrum inspection capable of realizing quantitative liquid dripping, characterized in that it mainly comprises an automatic rotating conveyor belt (1), a test tube (2), a photoelectric sensor (3), a PLC control system (4), a mechanical arm (5), a liquid adding controller (6), an automatic potentiometric titrator (7), a chemical spectrum analyzer (8), and a sound alarm (9).

[0004] Before the test tube (2) is placed in the feed port of the automatic rotating conveyor (1), it is labeled with a QR code to give it an identity tag. The photoelectric sensor (3) is composed of a laser light emitting element (31) and a CCD photoelectric detection element (32). When the vertical laser line emitted by the laser light emitting element (31) detects the presence of the test tube (2) and the QR code attached to the outside at the titration position, the CCD photoelectric detection element (32) captures the QR code. On the one hand, it can determine the presence of the test tube and provide a pulse electrical signal to be input into the PLC control system (4) for test tube counting and positioning. On the other hand, the coded identity of the test tube (2) is determined through the QR code.

[0005] After the PLC control system (4) receives the signal from the photoelectric sensor (3) that the test tube (2) is in place, the output signal will stop the motor (11) of the automatic rotating conveyor belt (1), control the mechanical arm (5) to move above the test tube (2), and control the mechanical arm (5) to descend to a specified height, so that the dripping port of the automatic potentiometric titrator (7) just enters the entrance of the test tube (2), and then triggers the automatic potentiometric titrator (7) installed on the mechanical arm (5) to perform liquid titration.

[0006] The automatic potentiometric titrator (7) comprises a liquid adding controller (71), a liquid storage device (72), a dropper (73) and an ultrasonic potentiometer (74), wherein the liquid adding controller (71) performs automatic liquid dripping control, and the ultrasonic potentiometer (74) determines the liquid level of the liquid in the test tube in real time and transmits it to the PLC control system (4) for closed-loop control to determine the start and stop of the liquid dripping action of the liquid adding controller (71), thereby accurately controlling the liquid dripping amount.

[0007] In order to allow the solution in the test tube (2) to fully react with the test agent, an annular magnetic stirring bar (21) is placed in each test tube (2), and a miniature electromagnetic stirrer (12) is installed inside the test tube fixing groove (11) of the automatic rotating conveyor belt (1) below each test tube. The stirring work is completed by using electromagnetic driving force, so that the solution in the test tube (2) and the test agent can be uniformly stirred, thereby allowing them to fully react. After the automatic titration is completed and the liquid in the test tube (2) is fully stirred for a set period of time, the LED light source (81) of the chemical spectrometer (8) is used to emit fluorescence to illuminate the liquid in the test tube (2), and the spectrum photoelectric receiver (82) receives the fluorescence spectrum reflected by the liquid in the test tube (2), and obtains the liquid fluorescence spectrum curve, and provides it to the PLC control system (4) for comparison and judgment with the preset standard spectrum curve. If it is detected that the reagent does not meet the requirements of the ideal reagent, the chemical spectrometer (8) will transmit the signal to the PLC control system (4), and the PLC control system (4) will store the test tube number and output a signal to make the sound alarm (9) alarm, thereby realizing the automatic and intelligent screening process of the reagent and the spectrum data recording. When the chemical spectrometer (8) completes the detection, it will send a signal to the PLC control system (4) to control the mechanical arm (5) to rise to the initial height, and control the motor (11) of the automatic rotating conveyor belt (1) to start rotating, and measure the next test tube.

[0008] The flow line is a circular automatic rotating conveyor belt (1) from the feed inlet to the discharge outlet. The conveyor belt is provided with a test tube fixing groove (11) formed by a double-layer rubber mold with a hole in the middle, and a micro electromagnetic stirrer (12) is installed below. At the feed inlet, a QR code of the test tube (2) is pasted. When the test tube (2) reaches the detection position of the CCD photoelectric detection element (32), the CCD photoelectric detection element (32) detects the QR code and notifies the PLC control system (4) to stop the automatic rotating conveyor belt (1), and then controls the mechanical arm (5) to reach the top of the test tube (2) for titration operation. For different reagents, the PLC control system (4) can compile a program to automatically match the titration time, liquid level height, detection and analysis time of the chemical spectrometer (8), and stirring time of the micro electromagnetic stirrer (12).

[0009] The automatic potentiometric titrator (7) cooperates with the mechanical arm (5) to complete the titration of the test tube (2). When the test tube reaches the specified position, the mechanical arm (5) first moves to the top of the test tube (2), then descends, inserts the dropper (73) into the test tube (2), and drips the liquid. After the titration is completed, the mechanical arm (5) rises, so that the dropper (73) leaves the mouth of the test tube (2), and stands in a standby state at a specified height, waiting for the arrival of the next test tube, and then repeats the above steps.

[0010] Among them, the chemical spectrometer measures the spectral transmittance of the reaction liquid at multiple set wavelengths to calculate the spectral titration curve. The volume values ​​corresponding to the convex peaks on the curve are all color mutation points. The color mutation points are regarded as the points where the material structure changes. In addition, the filtering algorithm is used to eliminate the noise interference generated by the measurement, and the separated signals are included in the relevant variable factors, making the convex peaks of the spectral titration curve more obvious and clear. BRIEF DESCRIPTION OF THE DRAWINGS

[0011] Figure 1 A block diagram of an automated production line device capable of realizing chemical spectroscopy inspection of quantitative droplets.

[0012] Figure 2 Schematic diagram of the assembly line design structure.

[0013] Figure 3 Workflow diagram of the automatic potentiometric titrator. DETAILED DESCRIPTION

[0015] The following is a further detailed description of the embodiments of the present invention in conjunction with the accompanying drawings.

[0016] Figure 1A block diagram of a chemical spectrum inspection automatic assembly line device capable of realizing quantitative droplet. The chemical spectrum inspection automatic assembly line device capable of realizing quantitative droplet mainly comprises an automatic rotating conveyor belt (1), a test tube (2), a photoelectric sensor (3), a PLC control system (4), a mechanical arm (5), a liquid adding controller (6), an automatic potentiometric titrator (7), a chemical spectrum analyzer (8), and a sound alarm (9). Before the test tube (2) is placed in the feed port of the automatic rotating conveyor belt (1), it is required to be labeled with a two-dimensional code to give an identity tag. The photoelectric sensor (3) is composed of a laser light-emitting element (31) and a CCD photoelectric detection element (32). When the vertical laser line emitted by the laser light-emitting element (31) detects the presence of the test tube (2) and the two-dimensional code attached to the outside at the titration position, the CCD photoelectric detection element (32) captures the two-dimensional code. On the one hand, it can determine the presence or absence of the test tube and provide a pulse electrical signal to be input into the PLC control system (4) for test tube counting and positioning. On the other hand, the coded identity of the test tube (2) is determined by the two-dimensional code. After the PLC control system (4) receives the signal from the photoelectric sensor (3) that the test tube (2) is in place, the output signal will stop the motor (11) of the automatic rotating conveyor (1), control the mechanical arm (5) to move to the top of the test tube (2), and control the mechanical arm (5) to descend to a specified height, so that the dripping port of the automatic potentiometric titrator (7) just enters the entrance of the test tube (2), and then triggers the automatic potentiometric titrator (7) installed on the mechanical arm (5) to perform liquid titration. The automatic potentiometric titrator (7) includes a liquid adding controller (71), a liquid storage device (72), a dropper (73) and an ultrasonic potentiometer (74), wherein the liquid adding controller (71) performs automatic dripping control, and the ultrasonic potentiometer (74) judges the liquid level in the test tube in real time and transmits it to the PLC control system (4) for closed-loop control to determine the start and stop of the dripping action of the liquid adding controller (71), thereby accurately controlling the amount of dripping liquid. In order to allow the solution in the test tube (2) to fully react with the test agent, an annular magnetic stirring bar (21) is placed in each test tube (2), and a miniature electromagnetic stirrer (12) is installed inside the test tube fixing groove (11) of the automatic rotating conveyor belt (1) below each test tube. The stirring work is completed by using electromagnetic driving force, so that the solution in the test tube (2) and the test agent can be uniformly stirred, thereby allowing them to fully react.After the automatic titration is completed and the liquid in the test tube (2) is fully stirred for a set period of time, the LED light source (81) of the chemical spectrometer (8) is used to emit fluorescence to illuminate the liquid in the test tube (2), and the spectrum photoelectric receiver (82) receives the fluorescence spectrum reflected by the liquid in the test tube (2), and obtains the liquid fluorescence spectrum curve, and provides it to the PLC control system (4) for comparison and judgment with the preset standard spectrum curve. If it is detected that the reagent does not meet the requirements of the ideal reagent, the chemical spectrometer (8) will transmit the signal to the PLC control system (4), and the PLC control system (4) will store the test tube number and output a signal to make the sound alarm (9) alarm, thereby realizing the automatic and intelligent screening process of the reagent and the spectrum data recording. When the chemical spectrometer (8) completes the detection, it will send a signal to the PLC control system (4) to control the mechanical arm (5) to rise to the initial height, and control the motor (11) of the automatic rotating conveyor belt (1) to start rotating, and measure the next test tube.

[0017] Figure 2 Schematic diagram of the assembly line design structure. From the feed port to the discharge port, the assembly line is a circular automatic rotating conveyor belt (1), on which a test tube fixing groove (11) formed by a double-layer rubber mold with a hole in the middle is installed, and a micro electromagnetic stirrer (12) is installed below. At the feed port, the QR code of the test tube (2) is pasted. When the test tube (2) reaches the detection position of the CCD photoelectric detection element (32), the CCD photoelectric detection element (32) detects the QR code and notifies the PLC control system (4) to stop the automatic rotating conveyor belt (1), and then controls the mechanical arm (5) to reach the top of the test tube (2) for titration operation. For different reagents, the PLC control system (4) can compile a program to automatically match the titration time, liquid level height, detection and analysis time of the chemical spectrometer (8), and stirring time of the micro electromagnetic stirrer (12).

[0018] Figure 3 Workflow diagram of the automatic potentiometric titrator. The automatic potentiometric titrator (7) cooperates with the mechanical arm (5) to complete the titration of the test tube (2). When the test tube reaches the specified position, the mechanical arm (5) first moves to the top of the test tube (2), then descends, inserts the dropper (73) into the test tube (2), and drips the liquid. After the titration is completed, the mechanical arm (5) rises, causing the dropper (73) to leave the mouth of the test tube (2), and is in a standby state at a specified height, waiting for the arrival of the next test tube, and then repeats the above steps.

[0019] The above description of the present invention and its embodiments is not limited thereto, and the accompanying drawings are only one embodiment of the present invention. Without departing from the purpose of the present invention, any structure or embodiment similar to the technical solution designed without creativity shall fall within the protection scope of the present invention.

Claims

1. An automated production line device for chemical spectroscopy inspection that can realize quantitative droplet detection, characterized in that The invention comprises an automatic rotating conveyor belt (1), a test tube (2), a photoelectric sensor (3), a PLC control system (4), a mechanical arm (5), a liquid adding controller (6), an automatic potentiometric titrator (7), a chemical spectrometer (8), and a sound alarm (9); before the test tube (2) is placed in the feed port of the automatic rotating conveyor belt (1), it is labeled with a two-dimensional code to give it an identity tag; the photoelectric sensor (3) is composed of a laser light-emitting element (31) and a CCD photoelectric detection element (32); when the vertical laser line emitted by the laser light-emitting element (31) detects the presence of the test tube (2) and the two-dimensional code attached to the outside at the titration position, the CCD photoelectric detection element (32) captures the two-dimensional code, which can determine the presence of the test tube and provide a pulse electric current. The signal is input into the PLC control system (4) for test tube counting and positioning confirmation, and on the other hand, the coded identity of the test tube (2) is determined by the QR code; after the PLC control system (4) receives the signal that the photoelectric sensor (3) detects that the test tube (2) is in place, it outputs a signal to stop the motor (11) of the automatic rotating conveyor belt (1), controls the mechanical arm (5) to move above the test tube (2), and controls the mechanical arm (5) to descend to a specified height, so that the dripping port of the automatic potentiometric titrator (7) installed on the mechanical arm (5) is just inserted into the entrance of the test tube (2), and then triggers the automatic potentiometric titrator (7) to perform liquid titration; the automatic potentiometric titrator (7) includes a liquid addition controller (71), a liquid storage device (72), a dropper ( 73) and an ultrasonic potentiometer (74), wherein the liquid adding controller (71) performs automatic liquid dripping control, and the ultrasonic potentiometer (74) determines the liquid level of the liquid in the test tube in real time and transmits it to the PLC control system (4) for closed-loop control to determine the start and stop of the liquid dripping action of the liquid adding controller (71), thereby accurately controlling the liquid dripping amount; in order to make the solution in the test tube (2) and the tested agent fully react, an annular magnetic stirring bar (21) is placed in each test tube, and a micro electromagnetic stirrer (12) is installed inside the test tube fixing groove (11) of the automatic rotating conveyor belt (1) under each test tube, and the electromagnetic driving force is used to complete the stirring work, so that the solution in the test tube (2) and the tested agent are evenly stirred and fully reacted. After the automatic titration is completed and the liquid in the test tube (2) is stirred sufficiently for a set period of time, the LED light source (81) of the chemical spectrometer (8) is used to emit fluorescence to illuminate the liquid in the test tube (2), and the fluorescence spectrum reflected by the liquid in the test tube (2) is received by the spectral photoelectric receiver (82), and the liquid fluorescence spectrum curve is obtained and provided to the PLC control system (4), and compared and judged with the preset standard spectrum curve. If it is detected that the reagent does not meet the requirements of the ideal reagent, the chemical spectrometer (8) transmits the signal to the PLC control system (4), and the PLC control system (4) stores the test tube code number and outputs a control signal to make the sound alarm (9) alarm, thereby realizing the automatic and intelligent screening of the reagent and the recording of the spectrum data;When the chemical spectrometer (8) completes the test, it sends a signal to the PLC control system (4) to control the mechanical arm (5) to rise to the initial height and control the motor (11) of the automatic rotating conveyor belt (1) to start rotating to test the next test tube. ; 2. The automated assembly line device for chemical spectrum inspection of quantitative droplets according to claim 1, characterized in that The production line is a circular automatic rotating conveyor belt (1) from the feed inlet to the discharge outlet. The conveyor belt is provided with a test tube fixing groove (11) formed by a double-layer rubber mold with a hole in the middle, and a micro electromagnetic stirrer (12) is installed below. At the feed inlet, a two-dimensional code is pasted on the test tube (2). When the test tube (2) reaches the detection position of the CCD photoelectric detection element (32), the CCD photoelectric detection element (32) detects the two-dimensional code and notifies the PLC control system (4) to stop the automatic rotating conveyor belt (1), and then controls the mechanical arm (5) to reach the top of the test tube (2) to perform the titration operation. The automatic potentiometric titrator (7) is matched with the mechanical arm (5). The test tube (2) is closed to complete the titration of the test tube (2); when the test tube reaches the designated position, the mechanical arm (5) first moves to the top of the test tube (2), then descends, inserts the dropper (73) into the test tube (2), and starts dripping; after the titration is completed, the mechanical arm (5) rises, so that the dropper (73) leaves the mouth of the test tube (2), and stands by at a designated height, waiting for the arrival of the next test tube, and then repeats the above steps; for different reagents, the PLC control system (4) can be programmed to automatically set the matching titration time, test tube liquid level height, chemical spectrometer (8) detection and analysis time, and micro electromagnetic stirrer (12) stirring time.

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