Composition for enriching blood and tonifying qi as well as preparation method and application thereof

Abstract

The invention relates to the technical field of health-care food, in particular to a blood-replenishing and qi-tonifying composition as well as a preparation method and application thereof. The D-ribose, the gamma-aminobutyric acid, the ferrous glycinate and the specific traditional Chinese medicine extract are combined in pairs or three or four, and a synergistic interaction effect can be achieved under a specific proportion. The components of the composition are medicinal and edible components, and the composition has the effect of tonifying qi and blood, is good in taste and high in compliance, and has a relatively good effect of improving the symptom of deficiency of qi and blood.

Description

Technical Field

[0001] The present invention relates to the technical field of health food, and in particular to a blood-replenishing and qi-replenishing composition and a preparation method and application thereof. Background Art

[0002] Traditional Chinese medicine regards Qi and blood as the foundation of life activities. Qi is the power source of human vitality and promotes the progress of life activities; blood plays a role in nourishing various organs and tissues of the body. Only when Qi and blood are full can the human body maintain health, with rosy complexion, moist skin, and abundant energy. When Qi and blood are insufficient, the body will experience a series of symptoms, such as dizziness, palpitations, shortness of breath, and weakness in the limbs. From the performance point of view, this is somewhat similar to the symptoms of anemia in Western medicine.

[0003] Iron deficiency anemia in Western medicine is mainly caused by insufficient iron intake, poor absorption or excessive loss of iron in the body, which leads to a lack of iron reserves in the body, thus affecting the synthesis of hemoglobin. As an important component of red blood cells, the content and function of hemoglobin directly affect the oxygen-carrying capacity of red blood cells. When iron deficiency leads to reduced hemoglobin synthesis, the normal function of red blood cells will also be affected. The number of red blood cells may decrease or their morphology and function may become abnormal, making it impossible to effectively transport oxygen to tissues and organs throughout the body.

[0004] Changes in red blood cell and hemoglobin levels are important indicators of the body's qi and blood status and the degree of anemia. In the process of replenishing qi and blood in traditional Chinese medicine, as the body's qi and blood gradually become sufficient, the number of red blood cells may gradually return to normal and the hemoglobin level will also rise from the perspective of Western medicine test indicators. For example, some women suffer from qi and blood deficiency due to excessive menstruation, accompanied by iron deficiency anemia. After a period of traditional Chinese medicine conditioning and replenishing qi and blood, the red blood cell and hemoglobin levels improved, the symptoms of anemia were alleviated, and the manifestations of qi and blood deficiency such as dizziness and fatigue were also alleviated.

[0005] It can be seen that the theory of qi and blood tonification in traditional Chinese medicine and iron deficiency anemia in Western medicine are essentially concerned with health issues related to human blood, and both use various methods to improve the levels of red blood cells and hemoglobin to maintain the normal physiological functions of the body. Most of the existing blood and qi tonification products are Chinese medicine oral liquids, pills, tablets, and granules, and most of them are pure Chinese medicine ingredients, with poor taste and low compliance. More importantly, these products are mainly qi tonification, supplemented by blood tonification, and the effect is not significant enough. Summary of the invention

[0006] In view of this, the technical problem to be solved by the present invention is to provide a blood-replenishing and qi-replenishing composition and a preparation method and application thereof.

[0007] The composition provided by the present invention is composed of two or more of the following components in parts by weight:

[0008]

[0009] The Chinese medicine extract is prepared from the following raw materials in parts by weight: 50 to 100 parts of donkey-hide gelatin peptide, 50 to 100 parts of ginseng, 100 to 200 parts of wolfberry, 50 to 100 parts of astragalus and 100 to 200 parts of jujube.

[0010] In the present invention, the Chinese herbal extract has been scientifically formulated and proportion-optimized, and has excellent blood-replenishing and qi-replenishing effects. After specific optimization, it can be used in combination with ribose, γ-aminobutyric acid or ferrous glycine to produce a synergistic effect.

[0011] In the present invention, the preparation of the Chinese medicine extract includes three methods, namely, percolation, heating reflux extraction and water decoction. The extracts prepared by the three methods all have good effects of nourishing blood and qi.

[0012] The percolation method specifically includes: wetting and soaking ginseng, astragalus, wolfberry and jujube in 60% to 70% ethanol aqueous solution and then percolating; the extract is concentrated, dried and crushed, and then mixed with donkey-hide gelatin to obtain the Chinese medicine extract.

[0013] In this method, the volume fraction of ethanol in the ethanol aqueous solution is 65%. Preferably, the method comprises: wetting ginseng, astragalus, wolfberry, and jujube with 1 times the mass of 65% ethanol aqueous solution for 30 minutes, then adding 65% ethanol aqueous solution until the medicinal materials are covered, soaking for 24 hours, and then performing percolation extraction, the percolation rate is 3ml / 1000g, and the total amount of 65% ethanol is 5.5 times the amount of the medicinal materials. In this method, the collection of the percolation liquid is divided into two parts, the first part collects the percolation liquid equivalent to 85% of the amount of the medicinal materials, and the second part is the remaining percolation liquid. The second part of the leachate is concentrated under low temperature and reduced pressure at 50°C to 65°C and a vacuum degree of 0.07Mpa to 0.08MPa to a relative density of 1.050 to 1.060, then combined with the first part of the leachate, and again concentrated under low temperature and reduced pressure at 50°C to 65°C and a vacuum degree of 0.07Mpa to 0.08MPa to an extract with a relative density of 1.210, dried and crushed, and passed through a 100-mesh sieve to obtain the Chinese medicine extract.

[0014] The heating reflux extraction method specifically includes: extracting ginseng, astragalus, wolfberry and jujube with 60% to 70% ethanol aqueous solution by reflux, concentrating, drying and crushing the extract, and then mixing it with donkey-hide gelatin to obtain the Chinese medicine extract.

[0015] In this method, the volume fraction of ethanol in the ethanol aqueous solution is 65%. Preferably, the mass of the 65% ethanol aqueous solution is 6.5 times the sum of the masses of ginseng, astragalus, wolfberry and jujube, and the reflux extraction time is 2.5 hours. The concentration conditions include low temperature and reduced pressure concentration to a relative density of 1.150 to 1.250 under the conditions of 50°C to 65°C and a vacuum degree of 0.07Mpa to 0.08MPa. After the pulverization, the mixture is sieved through a 100-mesh sieve.

[0016] The decoction extraction comprises: decoct ginseng, astragalus, wolfberry and jujube in water, filter, concentrate, dry and grind the extract, and then mix it with donkey-hide gelatin to obtain the Chinese medicine extract.

[0017] In this method, before decocting, the ingredients are soaked in water with 10 times the mass of the ingredients for 24 hours, and the decocting times are twice. The mass of the water used for the first time is 10 times the mass of the sum of the mass of ginseng, astragalus, wolfberry and jujube, and the decocting time is 2 hours. The mass of the water used for the second time is 6 times the mass of the sum of the mass of ginseng, astragalus, wolfberry and jujube, and the decocting time is 1 hour. After the decoctions are combined, they are concentrated to a relative density of 1.150 to 1.250 under low temperature and reduced pressure at 65°C to 75°C and a vacuum degree of 0.07Mpa to 0.08MPa. After drying and crushing, they are sieved through a 100-mesh sieve to obtain the traditional Chinese medicine extract.

[0018] The present invention attempts to combine D-ribose, γ-aminobutyric acid, ferrous glycine and a specific Chinese medicine extract in pairs, or in combination of three, or in combination of four, and finds that the effect of the combined use of each component is better than that of using each component alone, and a significant synergistic effect can be produced under a specific ratio.

[0019] For example:

[0020] The combination of D-ribose and ferrous glycinate at a ratio of 490:2 can produce a synergistic effect.

[0021] The combination of Chinese herbal extract and GABA at a ratio of 90:40 can produce a synergistic effect.

[0022] The combination of GABA and ferrous glycinate at a ratio of 40:2 can produce a synergistic effect.

[0023] The combination of D-ribose and GABA at a ratio of 490:40 can produce a synergistic effect.

[0024] The combination of D-ribose and Chinese herbal extracts at a ratio of 490:90 can produce a synergistic effect.

[0025] The combination of ferrous glycinate and Chinese herbal extracts can produce a synergistic effect at a ratio of 2:90.

[0026] Therefore, the composition provided by the present invention consists of D-ribose and ferrous glycine, or consists of a Chinese medicine extract and γ-aminobutyric acid, or consists of γ-aminobutyric acid and ferrous glycine, or consists of D-ribose and γ-aminobutyric acid, or consists of D-ribose and a Chinese medicine extract, or consists of ferrous glycine and a Chinese medicine extract.

[0027] Alternatively, the composition provided by the present invention is composed of any three of D-ribose, γ-aminobutyric acid, ferrous glycine and a traditional Chinese medicine extract, for example, it is composed of γ-aminobutyric acid, ferrous glycine and a traditional Chinese medicine extract, or is composed of D-ribose, ferrous glycine and a traditional Chinese medicine extract, or is composed of D-ribose, γ-aminobutyric acid and a traditional Chinese medicine extract, or is composed of D-ribose, γ-aminobutyric acid and ferrous glycine.

[0028] Alternatively, the composition provided by the present invention consists of D-ribose, gamma-aminobutyric acid, ferrous glycine and a traditional Chinese medicine extract.

[0029] In some specific embodiments, the composition consists of the following components in parts by weight:

[0030]

[0031] In this embodiment, the mass ratio of the raw materials in the Chinese herbal extract is: donkey-hide gelatin: astragalus: ginseng: wolfberry, jujube = 75:75:75:150:150.

[0032] The present invention further provides the use of the above-mentioned composition in the preparation of products for replenishing qi and blood.

[0033] In the present invention, the invigorating qi and blood includes increasing the level of red blood cells and / or hemoglobin, improving sleep, improving symptoms of limb weakness and / or improving skin color.

[0034] Furthermore, the present invention also provides a product for replenishing qi and blood, comprising auxiliary materials and the composition as described above.

[0035] In the embodiment of the present invention, in the product for replenishing qi and blood, the mass fraction of the above-mentioned composition is 44.55%.

[0036] The dosage form of the product of the present invention is tablets, capsules, granules, powders, oral liquids, soft capsules, pills, pastes, teas, wines, beverages, chewable tablets, lozenges, effervescent tablets, drops, syrups or powders.

[0037] In some embodiments, the auxiliary materials include sweeteners, flavoring agents, acidulants and antioxidants.

[0038] Preferably, the sweetener is selected from at least one of glucose, white sugar, sucralose, fructose, maltose, lactose, xylitol, sorbitol, maltitol, mannitol, erythritol, steviol glycosides, mogroside, aspartame, acesulfame potassium, neotame, alitame, isomaltulose, thaumatin or ammonium glycyrrhizinate;

[0039] Preferably, the flavoring agent is selected from at least one of sweet orange powder, strawberry powder, lemon powder, apple powder, banana powder, grape powder, blueberry powder or mint powder;

[0040] Preferably, the acidulant is selected from at least one of sodium citrate, malic acid, tartaric acid or lactic acid;

[0041] Preferably, the antioxidant is selected from at least one of vitamin C, vitamin E, β-carotene, lycopene, anthocyanin, astaxanthin, lutein, coenzyme Q10, glutathione, tea polyphenols, grape seed extract, resveratrol, curcumin, caffeic acid, ferulic acid, rosmarinic acid or phytic acid.

[0042] In some specific embodiments, the auxiliary materials include glucose, sweet orange powder, white sugar, vitamin C, sodium citrate or sucralose.

[0043] More specifically, the product is prepared from the following raw materials in parts by weight:

[0044] 480 parts of glucose, 402 parts of sweet orange powder, 400 parts of white granulated sugar, 10 parts of vitamin C, 10 parts of sodium citrate, 3 parts of sucralose, 75 parts of donkey-hide gelatin, 75 parts of astragalus, 75 parts of ginseng, 150 parts of wolfberry, 150 parts of jujube, 490 parts of D-ribose, 40 parts of gamma-aminobutyric acid and 2 parts of ferrous glycine.

[0045] Furthermore, the preparation method of the present invention comprises:

[0046] Pass D-ribose, sweetener, flavoring agent, acidulant and antioxidant through a 100-mesh sieve three times, mix well and divide into two portions;

[0047] Add Chinese herbal medicine extract and γ-aminobutyric acid to one of them, sieve through 100 meshes to mix evenly and then fill it;

[0048] Add ferrous glycine to the other portion, sieve through a 100-mesh sieve, mix well and then fill.

[0049] Since γ-aminobutyric acid is easy to absorb moisture and change color under the action of metal ions, AB packaging is adopted in the present invention.

[0050] Furthermore, the present invention also provides a method for replenishing qi and blood, which comprises administering the composition or product as described above.

[0051] In the present invention, the subjects of qi and blood tonification include humans or mammals, and the mammals include bovines, equines, ovines, porcines, canines, felines, rodents, and primates.

[0052] The present invention combines D-ribose, gamma-aminobutyric acid, ferrous glycine and a specific Chinese medicine extract in pairs, or in three combinations, or in four combinations, and can produce a synergistic effect under a specific ratio. The components of the composition come from the components that can be used as both medicine and food, and it has the effects of replenishing both qi and blood, and has a good taste, high compliance, and a good effect on improving the symptoms of qi and blood deficiency. DETAILED DESCRIPTION

[0053] The present invention provides a composition for replenishing blood and qi, and a preparation method and application thereof. Those skilled in the art can refer to the content of this article and appropriately improve the process parameters to achieve the above. It should be particularly noted that all similar substitutions and modifications are obvious to those skilled in the art, and they are all considered to be included in the present invention. The method and application of the present invention have been described through preferred embodiments, and relevant personnel can obviously modify or appropriately change and combine the method and application of this article without departing from the content, spirit and scope of the present invention to implement and apply the technology of the present invention.

[0054] The terms "include", "comprising" and "having" are used interchangeably herein and are intended to indicate the inclusiveness of the solution, meaning that the solution may have other elements in addition to the listed elements. At the same time, it should be understood that the use of "include", "comprising" and "having" descriptions herein also provides a "consisting of..." solution.

[0055] The numerical ranges and parameters involved in the present invention have been presented in the specific embodiments as accurately as possible. However, any numerical value inherently inevitably contains standard deviations due to individual testing methods. Therefore, unless otherwise explicitly stated, it should be understood that all numerical ranges or specific data used in this disclosure may have certain reasonable deviations within a certain range, for example: within ±10%, ±5%, ±1% or ±0.5%.

[0056] Some cases are recorded in the embodiments and comparative examples of the present invention. The embodiments show some implementation methods of the present invention. However, this does not mean that the effects of the present invention can only be achieved in these cases. In fact, any concentration of each component between the two endpoint values ​​shown in the embodiments can achieve a good effect of relieving stomach pain, and the best cases are Examples 10 to 12. In addition, many attempts were made during the research and development process, such as using different ratios, extraction processes or extraction parameters, but the effects of these attempts were not as good as those of Examples 10 to 12, which will not be repeated here.

[0057] It should be understood that in the various embodiments of the present application, the size of the serial numbers of the above-mentioned processes does not mean the order of execution, some or all of the steps can be executed in parallel or sequentially, and the execution order of each process should be determined by its function and internal logic, and should not constitute any limitation on the implementation process of the embodiments of the present application.

[0058] The test materials used in the present invention are all common commercial products and can be purchased in the market.

[0059] The present invention will be further described below in conjunction with embodiments:

[0060] Comparative Example 1

[0061] The prescription is:

[0062] 480 parts of glucose, 402 parts of sweet orange powder, 400 parts of white sugar, 10 parts of vitamin C, 10 parts of sodium citrate, 3 parts of sucralose;

[0063] 75 parts of donkey-hide gelatin peptide, 75 parts of astragalus, 75 parts of ginseng, 150 parts of wolfberry, and 150 parts of jujube.

[0064] The preparation method comprises the following steps:

[0065] Step 1: Mix astragalus, ginseng, wolfberry and jujube, and grind them with a high-speed grinder to obtain a mixed powder of ginseng, astragalus, wolfberry and jujube.

[0066] Step 2: Add the mixed powder of ginseng, astragalus, wolfberry and jujube into a container, add 1 times the amount of 65% ethanol to moisten for 30 minutes, and then add 65% ethanol to 25 cm above the discharge surface in the percolation device. After soaking for 24 hours, percolation is performed. The percolation rate is 3 ml / 1000 g per minute, and 65% ethanol is used for a total of 5.5 times the amount of medicinal materials. The percolation liquid equivalent to 85% of the amount of medicinal materials is collected and stored separately. The remaining percolation liquid is collected, and after low-temperature decompression concentration at 50°C to 65°C and vacuum degree of 0.07Mpa to 0.08MPa, it is combined with the initial percolation liquid, and then low-temperature decompression concentration is performed at 50°C to 65°C and vacuum degree of 0.07Mpa to 0.08MPa to a relative density of 1.150 to 1.250, and then it is dried and crushed into 90g of 100 mesh fine powder.

[0067] Step 3: The glucose, orange powder, white sugar, vitamin C, sodium citrate and sucralose are sieved through a 100-mesh stainless steel sieve three times and mixed evenly, and the fine powder extracted from ginseng, astragalus, wolfberry and jujube and donkey-hide gelatin peptide are added, and the mixture is sieved through a 100-mesh sieve and mixed evenly before filling.

[0068] Comparative Example 2

[0069] The prescription is:

[0070] 480 parts of glucose, 402 parts of sweet orange powder, 400 parts of white sugar, 10 parts of vitamin C, 10 parts of sodium citrate, 3 parts of sucralose;

[0071] D-Ribose 490 parts.

[0072] The preparation method comprises the following steps:

[0073] The glucose, D-ribose, sweet orange powder, white sugar, vitamin C, sodium citrate and sucralose are passed through a 100-mesh stainless steel sieve three times, mixed evenly and filled.

[0074] Comparative Example 3

[0075] The prescription is:

[0076] 480 parts of glucose, 402 parts of sweet orange powder, 400 parts of white sugar, 10 parts of vitamin C, 10 parts of sodium citrate, 3 parts of sucralose;

[0077] 40 parts of gamma-aminobutyric acid.

[0078] The preparation method comprises the following steps:

[0079] The glucose, sweet orange powder, white sugar, vitamin C, sodium citrate and sucralose are sieved through a 100-mesh stainless steel sieve three times and mixed evenly, and then gamma-aminobutyric acid is added, sieved through a 100-mesh sieve and mixed evenly before filling.

[0080] Comparative Example 4

[0081] The prescription is:

[0082] 480 parts of glucose, 402 parts of sweet orange powder, 400 parts of white sugar, 10 parts of vitamin C, 10 parts of sodium citrate, 3 parts of sucralose;

[0083] 2 parts of ferrous glycinate.

[0084] The preparation method comprises the following steps:

[0085] The glucose, sweet orange powder, white sugar, vitamin C, sodium citrate and sucralose are sieved through a 100-mesh stainless steel sieve three times and mixed evenly, and then ferrous glycine is added, sieved through a 100-mesh sieve and mixed evenly before filling.

[0086] Example 1

[0087] The prescription is:

[0088] 480 parts of glucose, 402 parts of sweet orange powder, 400 parts of white sugar, 10 parts of vitamin C, 10 parts of sodium citrate, 3 parts of sucralose;

[0089] 490 parts of D-ribose and 2 parts of ferrous glycinate.

[0090] The preparation method comprises the following steps:

[0091] The glucose, D-ribose, sweet orange powder, white sugar, vitamin C, sodium citrate and sucralose are passed through a 100-mesh stainless steel sieve three times, ferrous glycine is added, and the mixture is passed through a 100-mesh sieve, mixed evenly and then filled.

[0092] Example 2

[0093] The prescription is:

[0094] 480 parts of glucose, 402 parts of sweet orange powder, 400 parts of white sugar, 10 parts of vitamin C, 10 parts of sodium citrate, 3 parts of sucralose;

[0095] 75 parts of donkey-hide gelatin peptide, 75 parts of astragalus, 75 parts of ginseng, 150 parts of wolfberry, and 150 parts of jujube;

[0096] 40 parts of gamma-aminobutyric acid.

[0097] The preparation method comprises the following steps:

[0098] Step 1 and step 2 are the same as in Comparative Example 1.

[0099] Step 3: Pass the glucose, orange powder, white sugar, vitamin C, sodium citrate and sucralose through a 100-mesh stainless steel sieve three times, add the fine powder extracted from ginseng, astragalus, wolfberry and jujube, donkey-hide gelatin and γ-aminobutyric acid, pass through a 100-mesh sieve, mix evenly and then fill.

[0100] Example 3

[0101] The prescription is:

[0102] 480 parts of glucose, 402 parts of sweet orange powder, 400 parts of white sugar, 10 parts of vitamin C, 10 parts of sodium citrate, 3 parts of sucralose;

[0103] 40 parts of gamma-aminobutyric acid and 2 parts of ferrous glycinate.

[0104] The preparation method comprises the following steps:

[0105] The glucose, sweet orange powder, white sugar, vitamin C, sodium citrate and sucralose are passed through a 100-mesh stainless steel sieve three times, mixed evenly and then evenly divided into two portions.

[0106] One of the portions is added with γ-aminobutyric acid, and the mixture is passed through a 100-mesh sieve and mixed evenly, and then filled into a package A of 6 g / bag.

[0107] Add ferrous glycine to the other portion, sieve through a 100-mesh sieve, mix evenly, and then fill into a package B of 5 g / bag.

[0108] A and B packaging are product packaging in bags.

[0109] Example 4

[0110] The prescription is:

[0111] 480 parts of glucose, 402 parts of sweet orange powder, 400 parts of white sugar, 10 parts of vitamin C, 10 parts of sodium citrate, 3 parts of sucralose;

[0112] 490 parts of D-ribose and 40 parts of gamma-aminobutyric acid.

[0113] The preparation method comprises the following steps:

[0114] The glucose, D-ribose, sweet orange powder, white sugar, vitamin C, sodium citrate and sucralose are passed through a 100-mesh stainless steel sieve three times, γ-aminobutyric acid is added, and the mixture is passed through a 100-mesh sieve, mixed evenly and then filled.

[0115] Example 5

[0116] The prescription is:

[0117] 480 parts of glucose, 402 parts of sweet orange powder, 400 parts of white sugar, 10 parts of vitamin C, 10 parts of sodium citrate, 3 parts of sucralose;

[0118] 75 parts of donkey-hide gelatin peptide, 75 parts of astragalus, 75 parts of ginseng, 150 parts of wolfberry, and 150 parts of jujube;

[0119] D-Ribose 490 parts.

[0120] The preparation method comprises the following steps:

[0121] Step 1 and step 2 are the same as in Example 1,

[0122] Step 3: Pass the glucose, D-ribose, orange powder, white sugar, vitamin C, sodium citrate and sucralose through a 100-mesh stainless steel sieve three times, mix well and divide into two parts, add the fine powder extracted from ginseng, astragalus, wolfberry and jujube and donkey-hide gelatin peptide, pass through a 100-mesh sieve, mix well and then fill.

[0123] Example 6

[0124] The prescription is:

[0125] 480 parts of glucose, 402 parts of sweet orange powder, 400 parts of white sugar, 10 parts of vitamin C, 10 parts of sodium citrate, 3 parts of sucralose;

[0126] 75 parts of donkey-hide gelatin peptide, 75 parts of astragalus, 75 parts of ginseng, 150 parts of wolfberry, and 150 parts of jujube;

[0127] 2 parts of ferrous glycinate.

[0128] The preparation method comprises the following steps:

[0129] Step 1 and step 2 are the same as in Example 1,

[0130] Step 3: Pass the glucose, orange powder, white sugar, vitamin C, sodium citrate and sucralose through a 100-mesh stainless steel sieve three times, mix well and divide into two portions.

[0131] One of the parts is added with fine powder extracted from ginseng, astragalus, wolfberry and jujube, and donkey-hide gelatin peptide, and the mixture is evenly mixed through a 100-mesh sieve and then filled into a package A of 6g / bag.

[0132] Add ferrous glycine to the other portion, sieve through a 100-mesh sieve, mix evenly, and then fill into a package B of 5 g / bag.

[0133] A and B packaging are product packaging in bags.

[0134] Example 7

[0135] prescription:

[0136] 480 parts of glucose, 402 parts of sweet orange powder, 400 parts of white sugar, 10 parts of vitamin C, 10 parts of sodium citrate, 3 parts of sucralose;

[0137] 75 parts of donkey-hide gelatin peptide, 75 parts of astragalus, 75 parts of ginseng, 150 parts of wolfberry, and 150 parts of jujube;

[0138] 490 parts of D-ribose and 40 parts of gamma-aminobutyric acid.

[0139] The preparation method comprises the following steps:

[0140] Step 1 and step 2 are the same as in Example 1,

[0141] Step 3: Pass the glucose, D-ribose, orange powder, white sugar, vitamin C, sodium citrate and sucralose through a 100-mesh stainless steel sieve three times, mix well and divide into two portions.

[0142] One of the parts is added with fine powder extracted from ginseng, astragalus, wolfberry and jujube, donkey-hide gelatin peptide and γ-aminobutyric acid, and the mixture is evenly mixed through a 100-mesh sieve and then filled into a package A of 6g / bag.

[0143] The other portion is passed through a 100-mesh sieve, mixed evenly, and then filled into packaging B with 5g / bag.

[0144] A and B packaging are product packaging in bags.

[0145] Example 8

[0146] prescription:

[0147] 480 parts of glucose, 402 parts of sweet orange powder, 400 parts of white sugar, 10 parts of vitamin C, 10 parts of sodium citrate, 3 parts of sucralose;

[0148] 75 parts of donkey-hide gelatin peptide, 75 parts of astragalus, 75 parts of ginseng, 150 parts of wolfberry, and 150 parts of jujube;

[0149] 490 parts of D-ribose and 2 parts of ferrous glycinate.

[0150] The preparation method comprises the following steps:

[0151] Step 1 and step 2 are the same as in Example 1,

[0152] Step 3: Pass the glucose, D-ribose, orange powder, white sugar, vitamin C, sodium citrate and sucralose through a 100-mesh stainless steel sieve three times, mix well and divide into two portions.

[0153] One of the parts is added with fine powder extracted from ginseng, astragalus, wolfberry and jujube, and donkey-hide gelatin peptide, and the mixture is evenly mixed through a 100-mesh sieve and then filled into a package A of 6g / bag.

[0154] Add ferrous glycine to the other portion, sieve through a 100-mesh sieve, mix evenly, and then fill into a package B of 5 g / bag.

[0155] A and B packaging are product packaging in bags.

[0156] Example 9

[0157] prescription:

[0158] 480 parts of glucose, 402 parts of sweet orange powder, 400 parts of white sugar, 10 parts of vitamin C, 10 parts of sodium citrate, 3 parts of sucralose;

[0159] 75 parts of donkey-hide gelatin peptide, 75 parts of astragalus, 75 parts of ginseng, 150 parts of wolfberry, and 150 parts of jujube;

[0160] 40 parts of gamma-aminobutyric acid and 2 parts of ferrous glycinate.

[0161] The preparation method comprises the following steps:

[0162] Step 1 and step 2 are the same as in Example 1,

[0163] Step 3: Pass the glucose, orange powder, white sugar, vitamin C, sodium citrate and sucralose through a 100-mesh stainless steel sieve three times, mix well and divide into two portions.

[0164] One of the parts is added with fine powder extracted from ginseng, astragalus, wolfberry and jujube, donkey-hide gelatin peptide and γ-aminobutyric acid, and the mixture is evenly mixed through a 100-mesh sieve and then filled into a package A of 6g / bag.

[0165] Add ferrous glycine to the other portion, sieve through a 100-mesh sieve, mix evenly, and then fill into a package B of 5 g / bag.

[0166] A and B packaging are product packaging in bags.

[0167] Example 10

[0168] prescription:

[0169] 480 parts of glucose, 402 parts of sweet orange powder, 400 parts of white sugar, 10 parts of vitamin C, 10 parts of sodium citrate, 3 parts of sucralose;

[0170] 75 parts of donkey-hide gelatin peptide, 75 parts of astragalus, 75 parts of ginseng, 150 parts of wolfberry, and 150 parts of jujube;

[0171] 490 parts of D-ribose, 40 parts of gamma-aminobutyric acid, and 2 parts of ferrous glycinate.

[0172] The preparation method comprises the following steps:

[0173] Step 1: Mix astragalus, ginseng, wolfberry and jujube, and grind them with a high-speed grinder to obtain a mixed powder of ginseng, astragalus, wolfberry and jujube.

[0174] Step 2: Add the mixed powder of ginseng, astragalus, wolfberry and jujube into a container, add 1 times the amount of 65% ethanol to moisten for 30 minutes, add 65% ethanol to the percolation device to 25 cm above the discharge surface, soak for 24 hours, and then percolate. The percolation rate is 3 ml / 1000 g per minute, and 65% ethanol is used in total for 5.5 times the amount of medicinal materials. The percolation liquid equivalent to 85% of the amount of medicinal materials is collected and stored separately. The remaining percolation liquid is collected, and after low-temperature decompression concentration at 50°C to 65°C and vacuum degree of 0.07Mpa to 0.08MPa, it is combined with the initial percolation liquid, and then low-temperature decompression concentration is carried out at 50°C to 65°C and vacuum degree of 0.07Mpa to 0.08MPa to a relative density of 1.15 to 1.25 (0.14kg of extract with a relative density of 1.21) is carried out, and then it is dried and crushed into 90g of 100 mesh fine powder.

[0175] Step 3: Pass the glucose, D-ribose, orange powder, white sugar, vitamin C, sodium citrate and sucralose through a 100-mesh stainless steel sieve three times, mix well and divide into two portions.

[0176] One of the parts is added with fine powder extracted from ginseng, astragalus, wolfberry and jujube, donkey-hide gelatin peptide and γ-aminobutyric acid, and the mixture is evenly mixed through a 100-mesh sieve and then filled into a package A of 6g / bag.

[0177] Add ferrous glycine to the other portion, sieve through a 100-mesh sieve, mix evenly, and then fill into a package B of 5 g / bag.

[0178] A and B packaging are product packaging in bags.

[0179] Embodiment 11

[0180] prescription:

[0181] 480 parts of glucose, 402 parts of sweet orange powder, 400 parts of white sugar, 10 parts of vitamin C, 10 parts of sodium citrate, 3 parts of sucralose;

[0182] 75 parts of donkey-hide gelatin peptide, 75 parts of astragalus, 75 parts of ginseng, 150 parts of wolfberry, and 150 parts of jujube;

[0183] 490 parts of D-ribose, 40 parts of gamma-aminobutyric acid, and 2 parts of ferrous glycinate.

[0184] The preparation method comprises the following steps:

[0185] Step 1: Mix astragalus, ginseng, wolfberry and jujube, and grind them with a high-speed grinder to obtain a mixed powder of ginseng, astragalus, wolfberry and jujube.

[0186] Step 2: Add the mixed powder of ginseng, astragalus, wolfberry and jujube into a container, add 6.5 times the amount of 65% ethanol, reflux extraction for 2.5 hours, filter, and concentrate the filtrate under low temperature and reduced pressure at 50°C to 65°C and vacuum degree of 0.07Mpa to 0.08MPa to a relative density of 1.15 to 1.25 (0.14kg of extract of 1.21), dry it, and then grind it into 90g of 100 mesh fine powder.

[0187] Step 3: Pass the glucose, D-ribose, orange powder, white sugar, vitamin C, sodium citrate and sucralose through a 100-mesh stainless steel sieve three times, mix well and divide into two portions.

[0188] One of the parts is added with fine powder extracted from ginseng, astragalus, wolfberry and jujube, donkey-hide gelatin peptide and γ-aminobutyric acid, and the mixture is evenly mixed through a 100-mesh sieve and then filled into a package A of 6g / bag.

[0189] Add ferrous glycine to the other portion, sieve through a 100-mesh sieve, mix evenly, and then fill into a package B of 5 g / bag.

[0190] A and B packaging are product packaging in bags.

[0191] Example 12

[0192] prescription:

[0193] 480 parts of glucose, 402 parts of sweet orange powder, 400 parts of white sugar, 10 parts of vitamin C, 10 parts of sodium citrate, 3 parts of sucralose;

[0194] 75 parts of donkey-hide gelatin peptide, 75 parts of astragalus, 75 parts of ginseng, 150 parts of wolfberry, and 150 parts of jujube;

[0195] 490 parts of D-ribose, 40 parts of gamma-aminobutyric acid, and 2 parts of ferrous glycinate.

[0196] The preparation method comprises the following steps:

[0197] Step 1: Mix astragalus, ginseng, wolfberry and jujube, and grind them with a high-speed grinder to obtain a mixed powder of ginseng, astragalus, wolfberry and jujube.

[0198] Step 2: Add the mixed powder of ginseng, astragalus, wolfberry and jujube into a container, add 10 times the amount of purified water, soak for 24 hours, boil and extract at 100°C for 2 hours, filter, collect the filtrate for later use, add 6 times the amount of water to the residue, boil and extract at 100°C for 1 hour, filter, discard the residue, collect the filtrate and combine it with the first extract, concentrate at low temperature and reduced pressure at 65°C to 75°C and vacuum degree of 0.07Mpa to 0.08MPa to a relative density of 1.15 to 1.25 (0.16kg of 1.20 extract), dry and then crush into 90g of 100 mesh fine powder.

[0199] Step 3: Pass the glucose, D-ribose, orange powder, white sugar, vitamin C, sodium citrate and sucralose through a 100-mesh stainless steel sieve three times, mix well and divide into two portions.

[0200] One of the parts is added with fine powder extracted from ginseng, astragalus, wolfberry and jujube, donkey-hide gelatin peptide and γ-aminobutyric acid, and the mixture is evenly mixed through a 100-mesh sieve and then filled into a package A of 6g / bag.

[0201] Add ferrous glycine to the other portion, sieve through a 100-mesh sieve, mix evenly, and then fill into a package B of 5 g / bag.

[0202] A and B packaging are product packaging in bags.

[0203] Efficacy verification

[0204] The efficacy of the composition described in the previous examples or comparative examples was verified in two parts: animal experiment and human experiment:

[0205] 1. Animal Experiments

[0206] 1. Experimental animals:

[0207] Kunming male mice weighing 18-22 g were used for verification and randomly divided into groups with 10 mice in each group.

[0208] Model animal preparation: Cut off about 2.5 cm of the mouse's tail and draw blood for testing as the blank group data. Then immerse the mouse's tail with the tip of the tail cut off in 36.5℃ warm water, squeeze the tail with your fingers to draw 0.8 ml of blood. After bleeding for 24 hours, draw blood for testing and collect the data as the model group data.

[0209] 2. Experimental groups:

[0210] In the experimental group, the mice were given the products of Examples 1 to 12 and Comparative Examples 1 to 4 after bleeding, respectively. One bag of each product A and B was dissolved in 50 ml of warm water (if there was only one bag, the first generation product was dissolved in warm water). Each mouse was gavaged once every 8 hours every day, 0.5 ml each time. After three weeks of continuous administration, blood was taken again for testing.

[0211] 3. Experimental results:

[0212] The red blood cell and hemoglobin levels of each group of mice were tested:

[0213] Table 1 Ferrous glycine and ribose

[0214]

[0215] Table 2 GABA and Chinese medicine

[0216]

[0217] Table 3 Ferrous glycine and gamma-aminobutyric acid

[0218]

[0219] Table 4 Ribose and GABA

[0220]

[0221] Table 5 Ribose and Chinese medicine

[0222]

[0223] Table 6 Iron glycine and Chinese medicine group

[0224]

[0225] Table 7 Example 10 and Example 3 / 5 Group

[0226]

[0227] Note: ↑ in the table indicates that the level is higher than that after blood loss.

[0228] The results showed that each group of tested substances could restore the hemoglobin and red blood cell levels to varying degrees, and the product group of Example 10 had the best effect.

[0229] 4. Evaluate the interaction effects between the test substances:

[0230] According to the article "Evaluation of Research Methods for Measuring the Effect of Combined Drugs" by Guo Jianyou, Huo Hairu, and Jiang Tingliang, the evaluation methods for drug combined effects include simple algebra and addition method, isobolometric method evaluation, etc. The present invention uses simple algebra and addition method for evaluation as follows:

[0231] Simple Algebra and Addition: E A+B =E A +E B

[0232] Among them, E A is the effect of drug A alone at the current dose, E B It is the effect of drug B when used alone at the current dose. When drugs A and B are used together at the doses they would take alone, the combined effect is the algebraic sum of the individual effects. The formula for determining the combined effect can be obtained by transformation: q = (E A+B -E A ) / EB but requires E A =E B , so as not to A 、E B The q value changes greatly when the two are interchanged. The meaning of the q value is: q = 1 is additive effect, q > 1 is synergistic effect, and q < 1 is antagonistic effect.

[0233] Table 8

[0234]

[0235] The experimental results show that: in the composition provided by the present invention, each component is indispensable and plays a good synergistic role together. Moreover, it has been verified that no matter how the groups are grouped, the q value of each group can be greater than 1, showing a synergistic effect.

[0236] 2. Human Experiments

[0237] 350 adults with hemoglobin values ​​lower than the normal value of 110mg / ml, less than 5 hours of sleep, dark yellow skin, and weak limbs were selected as subjects. The subjects were divided into 7 groups, 50 people in each group:

[0238] Experimental groups 7 to 12 took the samples of Examples 7 to 12 three times a day, one bag of AB each time, and the hemoglobin values ​​were measured after taking them for 25, 50 and 75 days.

[0239] The control group took the positive drug Jianpi Shengxue Granules 3 times a day, 3 bags each time, for 75 consecutive days, and the hemoglobin value was measured after 25 days, 50 days, and 75 days. The main effects of Jianpi Yangsheng Granules: invigorating the spleen and stomach, nourishing blood and calming the mind. Ingredients: Codonopsis, Poria, Atractylodes (fried), Licorice, Astragalus, Chinese Yam, Chicken Gizzard (fried), Tortoise Shell (vinegar), Ophiopogon, Schisandra (vinegar), Dragon Bone, Oyster (calcined), Jujube, Ferrous Sulfate. Excipients: Sucrose, Vitamin C, Citric Acid, β-cyclodextrin.

[0240] The number of people with elevated hemoglobin levels, sleep duration, skin color changes, and limb weakness changes were counted. The results are shown in the table below:

[0241] Table 9 Changes in Qi and Blood (Unit: Hemoglobin value mg / ml)

[0242]

[0243]

[0244]

[0245] The experimental results show that the compositions provided in the embodiments of the present invention have good effects of replenishing blood and iron, and have the effect of improving sleep.

[0246] The above are only preferred embodiments of the present invention. It should be pointed out that, for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A composition, which is composed of two or more of the following components in parts by weight: in, The Chinese medicine extract is prepared from the following raw materials in parts by weight: 50 to 100 parts of donkey-hide gelatin peptide, 50 to 100 parts of ginseng, 100 to 200 parts of wolfberry, 50 to 100 parts of astragalus and 100 to 200 parts of jujube.

2. The composition according to claim 1, characterized in that The preparation of the Chinese medicine extract comprises: Wetting and soaking ginseng, astragalus, wolfberry and jujube in 60% to 70% ethanol aqueous solution and then performing percolation, concentrating, drying and crushing the extract, and mixing it with donkey-hide gelatin to obtain the Chinese medicine extract; Alternatively, ginseng, astragalus, wolfberry and jujube are extracted by reflux with 60% to 70% ethanol aqueous solution, the extract is concentrated, dried and crushed, and then mixed with donkey-hide gelatin to obtain the Chinese medicine extract; Alternatively, ginseng, astragalus, wolfberry and jujube are decocted in water for extraction, and the extract is filtered, concentrated, dried and crushed, and then mixed with donkey-hide gelatin to obtain the Chinese medicine extract.

3. The composition according to claim 1 or 2, characterized in that The composition is composed of the following components in parts by weight: In the Chinese herbal medicine extract, the mass ratio of each raw material is: Donkey-hide gelatin peptide: Astragalus: Ginseng: Wolfberry, Jujube = 75:75:75:150:

150.

4. Use of the composition according to any one of claims 1 to 3 in the preparation of products for replenishing qi and blood.

5. The use according to claim 4, characterized in that: The invigorating qi and blood includes increasing the level of red blood cells and / or hemoglobin, improving sleep, improving symptoms of weakness in the limbs and / or improving skin color.

6. A product for invigorating qi and blood, comprising auxiliary materials and the composition according to any one of claims 1 to 3.

7. The product according to claim 6, characterized in that In the product for replenishing qi and blood, the mass fraction of the composition according to any one of claims 1 to 3 is 44.55%.

8. The product according to claim 6, characterized in that The auxiliary materials include sweeteners, flavoring agents, acidulants and antioxidants; The sweetener is selected from at least one of glucose, white sugar, sucralose, fructose, maltose, lactose, xylitol, sorbitol, maltitol, mannitol, erythritol, steviol glycosides, mogroside, aspartame, acesulfame potassium, neotame, alitame, isomaltulose, thaumatin or ammonium glycyrrhizinate; The flavoring agent is selected from at least one of sweet orange powder, strawberry flavor, lemon flavor, apple flavor, banana flavor, grape flavor, blueberry flavor or mint flavor; The acidulant is selected from at least one of sodium citrate, malic acid, tartaric acid, lactic acid, acetic acid, phosphoric acid, fumaric acid, gluconic acid, succinic acid, adipic acid, succinic acid, glutaric acid, sorbic acid, benzoic acid, maleic acid, oxalic acid, propionic acid or butyric acid; The antioxidant is selected from at least one of vitamin C, vitamin E, β-carotene, lycopene, anthocyanin, astaxanthin, lutein, coenzyme Q10, glutathione, tea polyphenols, grape seed extract, resveratrol, curcumin, caffeic acid, ferulic acid, rosmarinic acid or phytic acid.

9. The product according to any one of claims 6 to 8, characterized in that: It is prepared from the following raw materials in parts by weight: 480 parts of glucose, 402 parts of sweet orange powder, 400 parts of white granulated sugar, 10 parts of vitamin C, 10 parts of sodium citrate, 3 parts of sucralose, 75 parts of donkey-hide gelatin, 75 parts of astragalus, 75 parts of ginseng, 150 parts of wolfberry, 150 parts of jujube, 490 parts of D-ribose, 40 parts of gamma-aminobutyric acid and 2 parts of ferrous glycine.

10. A method for preparing the product according to any one of claims 6 to 9, comprising: Pass D-ribose, sweetener, flavoring agent, acidulant and antioxidant through a 100-mesh sieve three times, mix well and divide into two parts. Add Chinese herbal medicine extract and γ-aminobutyric acid to one of them, sieve through 100 meshes to mix evenly and then fill it; Add ferrous glycine to the other portion, sieve through a 100-mesh sieve, mix well and then fill.

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