Non-invasive blood glucose detection device

Abstract

The invention provides a non-invasive blood glucose detection device. The non-invasive blood glucose detection device comprises a flexible circuit board, at least one blood glucose detection module and an adhesive layer, the at least one blood glucose detection module is arranged on the flexible circuit board, and each blood glucose detection module comprises a blocking structure, a light-emitting element, a light sensing element and a transparent cover plate. The blocking structure forms a first space and a second space which are isolated from each other; the light-emitting element and the light sensing element are respectively positioned in the first space and the second space; the transparent cover plate is combined with the blocking structure to seal the first space and the second space. The adhesive layer is arranged on the flexible circuit board and located on the periphery of the at least one blood glucose detection module.

Description

Technical Field

[0001] The invention relates to a blood sugar detection device, in particular to a non-invasive blood sugar detection device using a flexible circuit board as a substrate. Background Art

[0002] Existing non-invasive blood glucose testing devices use hard materials as the substrate of the device, such as ceramic substrates, silicon substrates, semiconductor substrates, etc., and then set light-emitting elements and light sensing elements on the substrate to perform the corresponding blood glucose testing function. However, the hard substrate easily causes many inconveniences when the existing non-invasive blood glucose testing device is fixed to the user's body. Therefore, in order to facilitate the non-invasive blood glucose testing device to be fixed to the user's body, the aforementioned device must be equipped with elements that can be worn on the user's body, such as bracelets, fixing belts, etc., so that the aforementioned device is often exposed outside the user's clothing, thereby affecting the user's privacy.

[0003] Therefore, how to design a non-invasive blood glucose detection module that can improve the above-mentioned problems is indeed a topic worth studying. Summary of the invention

[0004] The object of the present invention is to provide a non-invasive blood sugar detection device using a flexible printed circuit board as a substrate.

[0005] Another object of the present invention is to provide a concealed non-invasive blood glucose detection device.

[0006] To achieve the above-mentioned purpose, the non-invasive blood glucose detection device of the present invention includes a flexible circuit board, at least one blood glucose detection module and an adhesive layer. At least one blood glucose detection module is arranged on the flexible circuit board, and each blood glucose detection module includes a barrier structure, a light-emitting element, a light-sensing element and a transparent cover. The barrier structure forms a first space and a second space that are isolated from each other; the light-emitting element and the light-sensing element are respectively located in the first space and the second space; the transparent cover is combined with the barrier structure to close the first space and the second space. The adhesive layer is arranged on the flexible circuit board and is located on the periphery of at least one blood glucose detection module.

[0007] In one embodiment of the present invention, the flexible printed circuit includes a base layer, a first conductive layer and a first protective layer. The base layer includes a first surface and a second surface. The first conductive layer is disposed on the first surface, and the first protective layer is disposed on the first conductive layer.

[0008] In one embodiment of the present invention, the flexible printed circuit further includes a second conductive layer and a second protective layer. The second conductive layer is disposed on the second surface, and the second protective layer is disposed on the second conductive layer.

[0009] In one embodiment of the present invention, the flexible printed circuit defines a setting area, at least one blood sugar detection module is set in the setting area, and the adhesive layer is located outside the setting area and surrounds the at least one blood sugar detection module.

[0010] In one embodiment of the present invention, the height of the adhesive layer is not less than the overall height of each blood glucose detection module.

[0011] In one embodiment of the present invention, there are a plurality of at least one blood sugar detection modules, and the blood sugar detection modules are arranged on the flexible printed circuit board in pairs and spaced apart from each other.

[0012] In one embodiment of the present invention, each blood sugar detection module further includes a ceramic substrate, and each blood sugar detection module is connected to the flexible printed circuit board through the ceramic substrate.

[0013] In one embodiment of the present invention, the blocking structure is made of a non-light-transmissive material.

[0014] In one embodiment of the present invention, a transparent sealing material is filled in the first space and the second space of the blood glucose detection module to protect the light emitting element and the light sensing element.

[0015] In one embodiment of the present invention, the transparent cover further includes a coating, and the coating is a multi-layer structure formed by alternately stacking hydrogenated silicon layers and silicon dioxide layers.

[0016] Accordingly, the non-invasive blood glucose detection device of the present invention uses a flexible circuit board in conjunction with an adhesive layer so that the detection surface of the blood glucose detection device can be directly adhered to the user's skin, and the setting surface relative to the detection surface can be set on the inside of clothing through the flexible characteristics of the flexible circuit board. Compared with the existing non-invasive blood glucose detection module, it can provide the device with convenience in setting and concealment effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 FIG. 4 is a schematic diagram of a first embodiment of a non-invasive blood glucose detection device according to the present invention.

[0018] Figure 2 It is an overall top view of the first embodiment of the non-invasive blood glucose detection device of the present invention.

[0019] Figure 3 FIG. 4 is a schematic diagram of a second embodiment of the non-invasive blood glucose detection device of the present invention.

[0020] Figure 4 It is an overall top view of the third embodiment of the non-invasive blood glucose detection device of the present invention.

[0021] Figure 5 For along Figure 4 Section view of midline segment AA.

[0022] Figure 6 FIG. 4 is a schematic diagram of a fourth embodiment of the non-invasive blood glucose detection device of the present invention.

[0023] Description of reference numerals:

[0024] 1. 1a, 1b, 1c Non-invasive blood glucose monitoring device

[0025] 10, 10a Flexible printed circuit board

[0026] 11. Base Layer

[0027] 111 Page 1

[0028] 112 Second Side

[0029] 12. First conductive layer

[0030] 13 First protective layer

[0031] 14 Second conductive layer

[0032] 15 Second protective layer

[0033] 20, 20c Blood glucose detection module

[0034] 21 Barrier structure

[0035] 22 Light-emitting element

[0036] 23 Light sensing element

[0037] 24 Transparent cover

[0038] 241 Coating

[0039] 25 Transparent sealing material

[0040] 26 Ceramic Substrate

[0041] 30, 30c Adhesive layer

[0042] 40 Drivers

[0043] 50 Control Unit

[0044] S1 First Space

[0045] S2 Second space. DETAILED DESCRIPTION

[0046] Since the various aspects and embodiments are only exemplary and non-limiting, after reading this specification, ordinary technicians may also come up with other aspects and embodiments without departing from the scope of the present invention. According to the following detailed description and claims, the features and advantages of the embodiments will be more prominent.

[0047] In this document, "a" or "an" is used to describe the elements and components described herein. This is only for convenience of description and to provide a general meaning to the scope of the present invention. Therefore, unless it is obvious that it is otherwise intended, such description should be understood to include one or at least one, and the singular also includes the plural.

[0048] In this article, the terms "first" or "second" and the like ordinal numbers are mainly used to distinguish or refer to the same or similar elements or structures, and do not necessarily imply the order of these elements or structures in space or time. It should be understood that in some cases or configurations, the ordinal numbers can be used interchangeably without affecting the implementation of the present invention.

[0049] As used herein, the terms "include", "have" or any other similar terms are intended to cover a non-exclusive inclusion. For example, an element or structure containing multiple elements is not limited to only those elements listed herein, but may include other elements that are not explicitly listed but are generally inherent to the element or structure.

[0050] Please refer to Figure 1 FIG. 1 is a schematic diagram of a first embodiment of a non-invasive blood glucose detection device of the present invention. Figure 1 As shown, the non-invasive blood glucose detection device 1 of the present invention comprises a flexible circuit board 10, at least one blood glucose detection module 20 and an adhesive layer 30, and the at least one blood glucose detection module 20 and the adhesive layer 30 are both disposed on the flexible circuit board 10. The flexible circuit board 10 is used to carry at least one blood glucose detection module 20, the adhesive layer 30 and other related components, and the flexible circuit board 10 itself can also be electrically connected to the aforementioned supporting components to perform signal transmission. In this embodiment, the flexible circuit board 10 at least comprises a base layer 11, a first conductive layer 12 and a first protective layer 13. The base layer 11 is used as a main structural member, and the base layer 11 is made of polyimide (PI) material. The base layer 11 comprises a first surface 111 and a second surface 112 opposite to each other. The first conductive layer 12 is disposed on the first surface 111 of the base layer 11, and the first conductive layer 12 is made of copper to provide a conductive effect. The first protective layer 13 is disposed on the first conductive layer 12, and the first protective layer 13 is made of a transparent adhesive material to provide an insulating protection effect. Here, the flexible printed circuit board 10 constitutes a single-layer flexible printed circuit board.

[0051] At least one blood sugar detection module 20 is disposed on the flexible circuit board 10, and each blood sugar detection module 20 is electrically connected to the first conductive layer 12 of the flexible circuit board 10. In the present embodiment, at least one blood sugar detection module 20 adopts a single blood sugar detection module 20, but the location and number of the at least one blood sugar detection module 20 can be adjusted according to different design requirements. Each blood sugar detection module 20 includes a barrier structure 21, a light emitting element 22, a light sensing element 23 and a transparent cover plate 24. The barrier structure 21 is disposed on the flexible circuit board 10, and the barrier structure 21 forms a first space S1 and a second space S2 that are isolated from each other. In one embodiment of the present invention, the barrier structure 21 is made of a non-light-transmitting (including visible light and invisible light) material, such as a black colloid material or other non-light-transmitting colloid material. Accordingly, the barrier structure 21 can prevent the light from interfering with each other between the first space S1 and the second space S2.

[0052] The light-emitting element 22 is disposed on the flexible circuit board 10, and the light-emitting element 22 is located in the first space S1 formed by the barrier structure 21. The light-emitting element 22 is mainly used as a light source to emit light toward the skin. In the present invention, the light-emitting element 22 can adopt a single LED light source, but the type, setting position and number of the light-emitting element 22 can be adjusted according to different design requirements. For example, the aforementioned light-emitting element 22 can adopt an LED light source that emits short-wave infrared (Short Wave InfraRed, referred to as SWIR), and its spectral range is between 700nm and 2000nm, but the present invention is not limited to this. The light-emitting element 22 can be electrically connected to the first conductive layer 12 of the flexible circuit board 10 through a metal wire.

[0053] The light sensing element 23 is disposed on the flexible printed circuit board 10, and the light sensing element 23 is located in the second space S2 formed by the barrier structure 21. The light sensing element 23 mainly receives the light transmitted back after diffuse reflection from the skin. In the present invention, the light sensing element 23 can adopt a single photo sensor (Photo Detector), but the type, setting position and number of the photo sensing element 23 can be adjusted according to different design requirements. For example, the aforementioned light sensing element 23 can adopt a photo sensor made of indium gallium arsenide (InGaAs), and its light absorption range is between 900nm and 1700nm, but the present invention is not limited to this. The light sensing element 23 can also be electrically connected to the first conductive layer 12 of the flexible printed circuit board 10 through a metal wire.

[0054] The transparent cover plate 24 is combined with the barrier structure 21, and the openings of the first space S1 and the second space S2 can be closed by combining the transparent cover plate 24 with the barrier structure 21, so that the first space S1 and the second space S2 form independent closed spaces respectively. One side of the transparent cover plate 24 is used to connect to the barrier structure 21, and the other side opposite is used to approach or contact the skin to be measured. The transparent cover plate 24 is made of transparent material, such as glass, etc., but the present invention is not limited to this. In addition, the transparent cover plate 24 includes a coating 241. The coating 241 is formed on the side of the transparent cover plate 24 used to approach or contact the skin, and the structure and functional application of the coating 241 can be adjusted according to different design requirements. For example, the coating 241 can adopt a dual band pass filter (Dual BandPass Filter) film, which is mainly a multiple layered structure formed by alternating silicon hydride (SiH) layers and silicon dioxide (SiO2) layers, but the present invention is not limited to this. By disposing the coating 241 , the transparent cover plate 24 can provide the effect of allowing light in a specific wavelength range to pass through, and can effectively block stray light in other unnecessary wavelength ranges.

[0055] In the present invention, the first space S1 and the second space S2 may be filled with a transparent sealing material 25, such as liquid optical glue or epoxy resin, but the present invention is not limited thereto. The transparent sealing material 25 can provide an auxiliary adhesive fixing effect for the transparent cover plate 24, so as to facilitate the combination of the transparent cover plate 24 and the barrier structure 21. In addition, the transparent sealing material 25 can also provide packaging and light penetration effects for the light emitting element 22, the light sensing element 23 and the aforementioned metal wires.

[0056] The adhesive layer 30 is disposed on the flexible circuit board 10, and the adhesive layer 30 is roughly located at the periphery of at least one blood glucose detection module 20. The adhesive layer 30 can be made of a material that is elastic and has skin-friendly properties, such as a skin-friendly tape. The adhesive layer 30 here can have a height, and the height of the adhesive layer 30 is not less than the overall height of each blood glucose detection module 20 (for example, the minimum distance from the surface of the first protective layer 13 of the flexible circuit board 10 to the transparent cover 24). For example, in the present embodiment, the overall height of each blood glucose detection module 20 is approximately 1 to 2 mm, and the height of the adhesive layer 30 is also approximately 1 to 2 mm in conjunction with each blood glucose detection module 20.

[0057] Please refer to Figure 1 and Figure 2 ,in Figure 2 FIG. 1 is an overall top view of the first embodiment of the non-invasive blood glucose detection device of the present invention. Figure 1 and Figure 2As shown, in the present invention, the installation area of ​​the flexible circuit board 10 is larger than that of the at least one blood sugar detection module 20, that is, the flexible circuit board 10 can define a sufficiently large installation area, and the at least one blood sugar detection module 20 can be completely installed in the installation area of ​​the flexible circuit board 10. For example, in this embodiment, the at least one blood sugar detection module 20 is installed in the central part of the flexible circuit board 10. The adhesive layer 30 is located outside the installation area and surrounds the at least one blood sugar detection module 20. For example, in this embodiment, the adhesive layer 30 is installed in the peripheral part of the flexible circuit board 10 close to the edge.

[0058] In addition, the non-invasive blood glucose detection device 1 of the present invention further includes a driving unit 40 and a control unit 50. The driving unit 40 is electrically connected to the flexible printed circuit 10, and is used to drive the light-emitting unit 22 of each blood glucose detection module 20 to perform a light-emitting operation; the driving unit 40 here can be an LED driver board (client board). The control unit 50 is electrically connected to the driving unit 40, and is used to transmit a signal to the driving unit 40 or receive a signal from the driving unit 40; the control unit 50 here can be a circuit board (EVB or PCB).

[0059] When the non-invasive blood glucose detection device 1 of the present invention is used, the transparent cover plate 24 of at least one blood glucose detection module 20 can be attached to the skin, and the flexible circuit board 10 located around the at least one blood glucose detection module 20 can be adhered to the skin through the adhesive layer 30 to provide a positioning or fixing effect for the at least one blood glucose detection module 20. Since the flexible circuit board 10 is flexible, it is easy to fix the base layer 11 along the inside of the user's clothing by adhesion, sewing or clamping, and the driving unit 40 and the control unit 50 are also hidden in the user's clothing. Accordingly, when the user uses the non-invasive blood glucose detection device 1 of the present invention, the various components of the non-invasive blood glucose detection device 1 of the present invention can be completely hidden in the user's clothing, which is not easy to be discovered by outsiders and protects the user's privacy. At the same time, by replacing the existing hard material substrate with the flexible circuit board 10, the manufacturing cost can also be effectively reduced.

[0060] Please refer to Figure 3 FIG. 2 is a schematic diagram of a second embodiment of the non-invasive blood glucose detection device of the present invention. This embodiment is a variation of the first embodiment described above, and mainly changes the structure of the flexible printed circuit board. Figure 3As shown, in this embodiment, the flexible circuit board 10a of the non-invasive blood glucose detection device 1a of the present invention further includes a second conductive layer 14 and a second protective layer 15. The second conductive layer 14 is disposed on the second surface 112 of the base layer 11, and the second conductive layer 14 is made of copper to provide a conductive effect. The second protective layer 15 is disposed on the second conductive layer 14, and the second protective layer 15 is made of a transparent adhesive material to provide an insulating protective effect. Here, the flexible circuit board 10a constitutes a double-layer flexible circuit board. Accordingly, the non-invasive blood glucose detection device 1a of the present invention can provide a faster and larger signal transmission function through the flexible circuit board 10a.

[0061] Please refer to Figure 4 and Figure 5 There is a third embodiment of the non-invasive blood glucose detection device of the present invention, wherein Figure 4 FIG. 1 is an overall top view of a third embodiment of the non-invasive blood glucose detection device of the present invention. Figure 5 For along Figure 4 This embodiment is a variation of the first embodiment, mainly changing the number of at least one blood sugar detection module 20. Figure 4 and Figure 5 As shown, in this embodiment, the non-invasive blood glucose detection device 1b of the present invention has a plurality of at least one blood glucose detection module 20, and the blood glucose detection modules 20 are arranged on the flexible circuit board 10 in a manner of being spaced apart in pairs. For example, the number of at least one blood glucose detection module 20 can be 4, and the blood glucose detection modules 20 are arranged in a manner of being spaced apart in pairs to form a 2x2 blood glucose detection module matrix, but the actual number of settings can be increased or decreased according to demand. Accordingly, the non-invasive blood glucose detection device 1b of the present invention can perform blood glucose detection operations through multiple blood glucose detection modules 20 at the same time, thereby increasing the accuracy and reliability of the detection.

[0062] Please refer to Figure 6 FIG. 4 is a schematic diagram of a fourth embodiment of the non-invasive blood glucose detection device of the present invention. This embodiment is a variation of the first embodiment described above, and mainly changes the structure of at least one blood glucose detection module. Figure 6 As shown, in this embodiment, each blood sugar detection module 20c of the non-invasive blood sugar detection device 1c of the present invention further includes a ceramic substrate 26, and each blood sugar detection module 20c is connected to the flexible circuit board 10 through the ceramic substrate 26. In other words, each blood sugar detection module 20c can adopt the design of an existing blood sugar detection module with a ceramic substrate 26 and a flexible circuit board 10 to provide a more stable detection effect. In addition, in this embodiment, as the height of each blood sugar detection module 20c changes, the height of the adhesive layer 30c will also be adjusted accordingly.

[0063] It should be noted that the structures and technical features disclosed in all the aforementioned embodiments of the non-invasive blood glucose testing device of the present invention can be combined in any two or even more combinations as required, so that the non-invasive blood glucose testing device of the present invention can provide flexible applications under various conditions or states.

[0064] The above embodiments are essentially only auxiliary explanations, and are not intended to be used to limit the embodiments of the application subject or the application or use of the embodiments. In addition, although at least one exemplary embodiment has been proposed in the aforementioned embodiments, it should be understood that the present invention can still have a large number of changes. It should also be understood that the embodiments described herein are not intended to limit the scope, use or configuration of the requested application subject in any way. On the contrary, the aforementioned embodiments will provide a simple guide for those of ordinary skill in the art to implement one or more of the embodiments. Furthermore, various changes can be made to the functions and arrangements of the components without departing from the scope defined by the claims, and the claims include known equivalents and all foreseeable equivalents at the time of the present application.

Claims

1. A non-invasive blood glucose detection device, comprising: A flexible printed circuit board; At least one blood sugar detection module is disposed on the flexible printed circuit board, and each of the blood sugar detection modules includes: A barrier structure, forming a first space and a second space isolated from each other; a light emitting element, located in the first space; a light sensing element located in the second space; and a transparent cover plate, combined with the barrier structure to close the first space and the second space; and An adhesive layer is disposed on the flexible printed circuit board and is located at the periphery of the at least one blood sugar detection module.

2. A non-invasive blood glucose detection device as described in claim 1, wherein the flexible circuit board includes a base layer, a first conductive layer and a first protective layer, the base layer includes a first surface and a second surface, the first conductive layer is arranged on the first surface, and the first protective layer is arranged on the first conductive layer.

3. The non-invasive blood glucose detection device as claimed in claim 2, wherein the flexible printed circuit further comprises a second conductive layer and a second protective layer, the second conductive layer is disposed on the second surface, and the second protective layer is disposed on the second conductive layer.

4. The non-invasive blood glucose detection device as claimed in claim 1, wherein the flexible printed circuit defines a setting area, the at least one blood glucose detection module is set in the setting area, and the adhesive layer is located outside the setting area and surrounds the at least one blood glucose detection module. 5 . The non-invasive blood glucose detection device as claimed in claim 1 , wherein a height of the adhesive layer is not less than an overall height of each of the blood glucose detection modules. 6 . The non-invasive blood glucose detection device as claimed in claim 1 , wherein the at least one blood glucose detection module is multiple, and the blood glucose detection modules are arranged on the flexible printed circuit board in pairs. 7 . The non-invasive blood glucose detection device as claimed in claim 1 , wherein each of the blood glucose detection modules further comprises a ceramic substrate, and each of the blood glucose detection modules is connected to the flexible printed circuit board via the ceramic substrate.

8. The non-invasive blood glucose detection device as claimed in claim 1, wherein the barrier structure is made of a non-light-transmissive material.

9. The non-invasive blood glucose detection device as claimed in claim 1, wherein a transparent sealing material is filled in the first space and the second space of the blood glucose detection module to protect the light emitting element and the light sensing element.

10. The non-invasive blood glucose detection device as claimed in claim 1, wherein the transparent cover further comprises a coating, and the coating is a multi-layer structure formed by alternately stacking silicon hydrogenated layers and silicon dioxide layers.

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