Quick-acting dysmenorrhea patch

Abstract

The invention discloses a quick-acting dysmenorrhea patch. The quick-acting dysmenorrhea patch comprises a medicine physical therapy layer which is prepared from the following raw materials in parts by weight, comprising 12 to 16 parts of borneol, 4 to 6 parts of musk, 12 to 18 parts of a saffron crocus extract concentrated solution, 9.5 to 14.5 parts of a white peony root extract concentrated solution, 9.5 to 14.5 parts of Chinese angelica, 10.5 to 15.5 parts of a frankincense extract, 10.5 to 15.5 parts of a myrrh extract, 3.5 to 5 parts of a motherwort herb extract concentrated solution, 6 to 9 parts of a ligusticum wallichii extract concentrated solution, 4 to 11 parts of a wormwood extract concentrated solution, 1.5 to 3 parts of nano magnetic powder and 6 to 12 parts of a far infrared material. The dysmenorrhea patch provided by the invention achieves a remarkable clinical curative effect by virtue of scientific proportioning of various traditional Chinese medicine components, a modern extraction technology and combination with a physical therapy, and has the characteristics of quick response, safety and convenience in use.

Description

Technical Field

[0001] The invention relates to the technical field of external medicine and health care products, in particular to a quick-acting dysmenorrhea patch. Background Art

[0002] Dysmenorrhea is one of the most common gynecological symptoms, which refers to lower abdominal pain and distension before, during or after menstruation, accompanied by backache or other discomfort, which seriously affects the quality of life. At present, when treating women with dysmenorrhea, most of them use oral Chinese medicine or oral Western medicine. The disadvantage is that the drugs have certain side effects and may cause adverse reactions to patients. Summary of the invention

[0003] Therefore, the technical problem to be solved by the present invention is to provide a quick-acting, safe and easy-to-use quick-acting dysmenorrhea patch. The dysmenorrhea patch provided in the present invention has achieved significant clinical efficacy by means of the scientific ratio of multiple Chinese medicine ingredients and modern extraction technology, as well as the combination with physical therapy, and the patient has no obvious adverse reactions.

[0004] In order to solve the above technical problems, the present invention provides the following technical solutions:

[0005] A quick-acting dysmenorrhea patch comprises a drug therapy layer, and the raw materials for making the drug therapy layer include, by weight:

[0006] 12-16 parts of borneol, 4-6 parts of musk, 12-18 parts of saffron extract concentrate, 9.5-14.5 parts of white peony extract concentrate, 9.5-14.5 parts of angelica, 10.5-15.5 parts of frankincense extract, 10.5-15.5 parts of myrrh extract, 3.5-5 parts of motherwort extract concentrate, 6-9 parts of chuanxiong extract concentrate, 4-11 parts of wormwood extract concentrate, 1.5-3 parts of nano magnetic powder and 6-12 parts of far-infrared material.

[0007] When preparing the drug therapy layer of the above-mentioned quick-acting dysmenorrhea patch, the raw materials and medical oil gel are mixed to form a paste mixture, and the paste mixture is evenly applied to the surface of the carrier, and the paste mixture forms a drug therapy layer on the surface of the carrier.

[0008] The above-mentioned quick-acting dysmenorrhea patch, when preparing the paste mixture, is carried out according to the following steps:

[0009] (a) mixing and stirring a saffron extract concentrate, a white peony extract concentrate, an ointment extract, a myrrh extract, a motherwort extract concentrate, a ligusticum chuanxiong extract concentrate and a wormwood extract concentrate to obtain a drug therapy layer precursor; the chemical properties of the active ingredients having the effect of relieving dysmenorrhea in the above drugs are not exactly the same, such as the main fat-soluble components in the ointment and myrrh that relieve dysmenorrhea, while the main water-soluble alkaloids in the motherwort and ligusticum chuanxiong that relieve dysmenorrhea; according to the specific physical and chemical properties of the active ingredients in the medicinal materials, different drugs are extracted and concentrated respectively according to different methods, which is conducive to obtaining more active ingredients;

[0010] (b) crushing borneol, musk and angelica and passing them through a 1000-mesh sieve respectively; directly crushing these three medicinal materials and applying them externally can reduce the loss of effective ingredients and achieve better therapeutic effects;

[0011] (c) uniformly mixing the borneol powder, angelica powder and musk powder obtained in step (b) with the nano magnetic powder, far infrared material and drug therapy layer precursor;

[0012] (d) adding medical oil gel to the mixture obtained in step (c) and stirring to obtain a paste-like mixture.

[0013] The preparation method of the above-mentioned quick-acting dysmenorrhea patch, saffron extract concentrate and wormwood extract concentrate is as follows: after washing and crushing the saffron or wormwood, use a 70% volume fraction ethanol solution at a solid-liquid ratio of 1:10g / mL to stir and extract at 60°C for 2 hours, filter and discard the residue, and concentrate the filtrate to 1 / 5 of the original volume at 50°C and a pressure of 0.08MPa.

[0014] The preparation method of the above-mentioned quick-acting dysmenorrhea patch and the white peony extract concentrate is as follows: after washing and crushing the white peony, ultrasonic extraction is performed at 45°C for 1 hour with a methanol solution with a volume fraction of 50% at a solid-liquid ratio of 1:8g / mL, and then concentrated to 1 / 5 of the original volume at 40°C and a pressure of 0.09MPa; the ultrasonic power is 300W.

[0015] The preparation method of the above-mentioned quick-acting dysmenorrhea patch, frankincense extract and myrrh extract is: after washing and crushing frankincense or myrrh, use petroleum ether with a boiling point of 60-90°C at a solid-liquid ratio of 1:12g / mL to stir and extract at room temperature for 24 hours, filter and discard the filter residue, and evaporate the filtrate to dry the petroleum ether at 70°C in an atmospheric distillation device.

[0016] The preparation method of the above-mentioned quick-acting dysmenorrhea patch, motherwort extract concentrate and Chuanxiong extract concentrate is as follows: after washing and crushing motherwort or Chuanxiong, reflux extraction is carried out at 90°C for 2 hours with water at a solid-liquid ratio of 1:15g / mL, the residue is discarded after filtering, and the filtrate is concentrated to 1 / 5 of the original volume at 80°C and a pressure of 0.08MPa.

[0017] The above-mentioned quick-acting dysmenorrhea patch, when preparing the paste mixture, weigh the raw materials according to the following weight parts: 12 parts of borneol, 5 parts of musk, 15 parts of saffron extract concentrate, 12 parts of white peony extract concentrate, 12 parts of angelica, 13 parts of frankincense extract, 13 parts of myrrh extract, 5 parts of motherwort extract concentrate, 9 parts of Chuanxiong extract concentrate, 5 parts of wormwood extract concentrate, 2 parts of nano magnetic powder and 12 parts of far-infrared material; the amount of medical oil gel used is 10 parts by weight.

[0018] The far-infrared material of the above-mentioned quick-acting dysmenorrhea patch is high-temperature bamboo charcoal powder, binchotan charcoal powder and / or far-infrared ceramic powder.

[0019] The carrier of the above-mentioned quick-acting dysmenorrhea patch is silk cloth, and the thickness of the silk cloth is greater than or equal to 80g / ㎡.

[0020] The medicinal properties, pharmacology and effects of the raw materials used in the present invention are as follows:

[0021] Borneol: pungent, bitter, slightly cold; enters the heart, liver, and lung meridians; has a refreshing fragrance and has the effects of refreshing the mind, clearing away heat and toxins, and improving eyesight and removing cataracts;

[0022] Musk: warm in nature, non-toxic, bitter in taste. Enters the heart, spleen, and liver meridians, and has the functions of opening the orifices, removing filth, unblocking the meridians, and dispersing stasis;

[0023] Saffron: sweet in taste and neutral in nature, can promote blood circulation, dissipate stasis, relieve depression and relieve pain;

[0024] White peony root: slightly cold in nature, bitter in taste, has the effects of calming the liver and relieving pain, nourishing blood and softening the liver, and restraining yin and sweating;

[0025] Angelica: Sweet, spicy, warm in nature, it has the effects of nourishing blood, regulating menstruation and relieving pain, moistening the intestines, anti-cancer, anti-aging, and immunity;

[0026] Frankincense: It tastes spicy and bitter, and is warm in nature. It has the effects of promoting blood circulation, relieving qi, relieving pain, reducing swelling and promoting tissue regeneration.

[0027] Myrrh: It tastes pungent and bitter, and is neutral in nature. It has the effects of dispersing blood stasis, relieving pain, reducing swelling and promoting tissue regeneration.

[0028] Motherwort: It tastes spicy and bitter, and is slightly cold in nature. It has the effects of promoting blood circulation and regulating menstruation, promoting diuresis and reducing swelling, and clearing away heat and detoxifying.

[0029] Chuanxiong: warm in nature, spicy in taste, has the effects of promoting blood circulation, promoting qi, dispelling wind and relieving pain.

[0030] Mugwort: It is bitter, pungent and warm in nature, and has the effects of removing dampness, disinfecting, stopping bleeding and dispelling cold.

[0031] Far-infrared material: The far-infrared rays it releases can penetrate deep into the subcutaneous tissue, making the molecules active, causing the blood vessels to dilate and accelerating the blood flow.

[0032] Nano magnetic powder: forms a magnetic field to make the molecules in the body resonate and promote the smooth flow of meridians.

[0033] The technical solution of the present invention achieves the following beneficial technical effects:

[0034] 1. The present invention provides a quick-acting dysmenorrhea patch, which is prepared by a scientific and reasonable formula and preparation method, achieves the effect of quickly relieving dysmenorrhea, and has significant clinical efficacy. The Chinese medicinal ingredients in the dysmenorrhea patch have a scientific ratio and can give full play to their respective pharmacological effects, such as analgesia, anti-inflammatory, and blood circulation promotion, etc., ensuring the comprehensive therapeutic effect of the dysmenorrhea patch. Nano magnetic powder and far-infrared materials can further enhance the permeability and absorption effect of the drug, and the two themselves can provide physical therapy for dysmenorrhea patients, which helps to quickly relieve the pain of patients. Clinical experiments show that the dysmenorrhea patch provided by the present invention is effective in quickly relieving dysmenorrhea, and the effect is more obvious as the use time increases.

[0035] 2. In the present invention, when preparing various concentrated extracts of medicinal materials as raw materials, extraction and concentration are carried out under suitable temperature and pressure conditions, thereby retaining the effective ingredients of the medicine and removing unnecessary impurities, thereby improving the purity and effect of the medicine. Ingredients such as borneol, musk and angelica are made into fine powders and directly applied externally, thereby ensuring the release of their medicinal effects to the greatest extent. The mixed paste is evenly coated on the silk cloth to ensure the uniform distribution of the medicine, thereby enhancing the application effect and comfort.

[0036] 3. The dysmenorrhea patch provided by the present invention can relieve the symptoms of primary dysmenorrhea and has a good curative effect. The effective ingredients of Chinese herbal medicine are extracted as dressings by using deep extraction processing and other technical means, so as to achieve the purpose of quick-acting cold dispelling, analgesia and menstruation dredge by combining drug treatment with acupoint treatment, and the dysmenorrhea patch provided by the present invention is an external patch and has no side effects on the human body. DETAILED DESCRIPTION

[0037] Example 1

[0038] The quick-acting dysmenorrhea patch prepared in this embodiment includes a silk cloth layer, a drug therapy layer and a protective film layer. The silk cloth layer, the drug therapy layer and the protective film layer are sequentially bonded together from top to bottom to form a whole, and the thickness of the silk cloth is ≥80g / ㎡. When in use, peel off the protective film layer, and stick the dysmenorrhea patch on the patient's abdomen so that the drug therapy layer contacts the patient's abdomen. The drug therapy layer is made of the following raw materials by weight:

[0039] Borneol 12 kg, musk 5 kg, saffron extract concentrate 15 kg, white peony extract concentrate 12 kg, angelica 12 kg, frankincense extract 13 kg, myrrh extract 13 kg, motherwort extract concentrate 5 kg, Chuanxiong extract concentrate 9 kg, wormwood extract concentrate 5 kg, nano magnetic powder 2 kg, and far-infrared material 12 kg. The far-infrared material in this embodiment is high-temperature bamboo charcoal powder, and in some other embodiments, the far-infrared material can be one or more of high-temperature bamboo charcoal powder, binchotan powder, and far-infrared ceramic powder.

[0040] The preparation of saffron extract concentrate, white peony extract concentrate, frankincense extract, myrrh extract, motherwort extract concentrate, chuanxiong extract concentrate and wormwood extract concentrate all includes washing, crushing, extraction, filtration and concentration processes. The specific methods of extraction and concentration are shown in Table 1.

[0041] Table 1

[0042]

[0043]

[0044] The extraction and concentration conditions are mainly determined based on the characteristics of the active substances in the medicinal materials that have the effect of relieving dysmenorrhea, combined with multiple experiments.

[0045] The concentrated solutions of various medicinal materials prepared by the method in Table 1 are mixed with each other and stirred evenly to obtain a drug therapeutic layer precursor.

[0046] Borneol, musk and angelica are crushed and passed through a 1000 mesh sieve to obtain powders with a particle size of less than or equal to 0.04 mm. The precursor of the drug therapy layer is mixed and stirred evenly with borneol powder, musk powder, angelica powder, nano magnetic powder and high-temperature bamboo charcoal powder, and then mixed with 10 kg of medical oil glue to form a paste mixture, which is applied to the surface of a silk cloth as a carrier, and the paste mixture forms a drug therapy layer on the surface of the silk cloth. A protective film is attached to the side of the drug therapy layer directly exposed to the air to obtain a quick-acting dysmenorrhea patch.

[0047] The medical oil adhesive used in this embodiment is a medical hot-melt pressure-sensitive adhesive, which is a commercially available product and has the characteristics of not causing allergies and having no toxic side effects.

[0048] The amount of the medical oil gel used in this embodiment is 10 kg. After mixing this amount of medical oil gel with the above-mentioned weight of raw materials, a paste mixture with suitable viscosity can be obtained. In other embodiments, when the amount of raw materials changes, the amount of the medical oil gel can also be adjusted according to the proportion, or the proportion of the medical oil gel can be increased or decreased as needed.

[0049] Clinical application verification example

[0050] In order to scientifically evaluate the efficacy of the dysmenorrhea patch prepared in Example 1 in relieving primary dysmenorrhea, a comparative efficacy experiment was designed and conducted.

[0051] Experimental materials and groups:

[0052] (1) Group A: the dysmenorrhea patch prepared in Example 1.

[0053] (2) Group B: This was the control group. No Chinese medicinal materials, far-infrared materials, or nano-magnetic powder were used. Medical oil gel was mixed with starch paste and then coated on the surface of silk cloth to prepare a patch.

[0054] (3) Group C: A commercially available brand of dysmenorrhea patch, the main ingredients of which include Chinese medicinal materials such as Cyperus rotundus, Angelica sinensis, Salvia miltiorrhiza, Evodia rutaecarpa, and Cinnamon bark, purchased from a regular pharmacy.

[0055] Subjects:

[0056] A total of 180 patients with primary dysmenorrhea were selected, with an age range of 18 to 45 years old, all of whom met the diagnostic criteria for primary dysmenorrhea. The patients were randomly divided into three groups (group a, group b, and group c), with 60 cases in each group. The statistics of dysmenorrhea severity in each group are shown in Table 2.

[0057] Table 2 Statistics of dysmenorrhea levels

[0058] Group Mild (example) Moderate (case) Severe (example) group a 17 25 18 Group B 16 27 17 Group C 15 28 17

[0059] Experimental methods:

[0060] Patients in group a used the dysmenorrhea patch prepared in Example 1 (the dysmenorrhea patch in group A), patients in group b used the control group patch (the patch in group B), and patients in group c used the commercially available dysmenorrhea patch (the dysmenorrhea patch in group C). All patients began to apply the patch 3 days before the onset of menstruation, one patch per day until the end of menstruation, which was a course of treatment, and three courses of treatment were applied continuously. The application position was 1.5 inches below the middle of the umbilicus, ensuring that the patch was applied tightly without falling off.

[0061] Observation indicators:

[0062] The changes in the degree of dysmenorrhea before and after the use of the dysmenorrhea patch were recorded and compared among the three groups of patients, and the visual analogue scale (VAS) was used for scoring. The scoring was conducted twice, the first scoring was conducted on the first day of menstruation in the first course of treatment, and the second scoring was conducted on the first day of the first menstruation after the third course of treatment. During each scoring, the number of cases of recovery (VAS score of 0), effectiveness (VAS score greater than 0, but decreased by 2 points or more), and ineffectiveness (VAS score greater than 0, and decreased by less than 2 points) was observed and recorded.

[0063] Experimental results:

[0064] Table 3 shows the results of the first scoring.

[0065] Table 3

[0066] Group Recovered (Example) Valid (Example) Invalid (Example) Total Effectiveness group a 15 18 27 55.0％ Group B 1 1 58 3.3％ Group C 6 12 42 30.0％

[0067] Note: Total effective rate (%) = (cured cases + effective cases) / total test cases

[0068] Table 4 shows the results of the second evaluation.

[0069] Table 4

[0070] Group Recovered (Example) Valid (Example) Invalid (Example) Total Effectiveness group a 31 23 6 90.0％ Group B 1 2 57 5.3％ Group C 17 20 23 61.7％

[0071] As shown in Tables 3 and 4, the dysmenorrhea patch prepared in Example 1 has the most cured cases and the highest total effective rate, and is suitable for patients of all ages and with all degrees of dysmenorrhea. In addition, the dysmenorrhea patch prepared in Example 1 also has the highest total effective rate in the first scoring. During the experiment, no adverse reactions were found in any patient.

[0072] The above results show that the dysmenorrhea patch prepared in Example 1 has a fast onset of action and no side effects, and is a quick-acting dysmenorrhea patch with good therapeutic effect, convenience and practicality.

[0073] Obviously, the above embodiments are merely examples for the purpose of clear explanation, and are not intended to limit the implementation methods. For those skilled in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the implementation methods here. The obvious changes or modifications derived therefrom are still within the scope of protection of the claims of this patent application.

Claims

1. A quick-acting dysmenorrhea patch, characterized in that: Including a drug therapy layer, the raw materials for making the drug therapy layer include, by weight: 12-16 parts of borneol, 4-6 parts of musk, 12-18 parts of saffron extract concentrate, 9.5-14.5 parts of white peony extract concentrate, 9.5-14.5 parts of angelica, 10.5-15.5 parts of frankincense extract, 10.5-15.5 parts of myrrh extract, 3.5-5 parts of motherwort extract concentrate, 6-9 parts of chuanxiong extract concentrate, 4-11 parts of wormwood extract concentrate, 1.5-3 parts of nano magnetic powder and 6-12 parts of far-infrared material.

2. The quick-acting dysmenorrhea patch according to claim 1, characterized in that: When preparing the drug therapy layer, the raw materials and medical oil gel are mixed to form a paste mixture, and the paste mixture is evenly applied on the surface of the carrier, and the paste mixture forms a drug therapy layer on the surface of the carrier.

3. The quick-acting dysmenorrhea patch according to claim 2, characterized in that: When preparing the paste mixture, follow the steps below: (a) mixing and stirring a saffron extract concentrate, a white peony extract concentrate, an frankincense extract, a myrrh extract, a motherwort extract concentrate, a chuanxiong extract concentrate, and an wormwood extract concentrate to obtain a drug therapy layer precursor; (b) crushing borneol, musk and angelica and passing through a 1000-mesh sieve respectively; (c) uniformly mixing the borneol powder, angelica powder and musk powder obtained in step (b) with the nano magnetic powder, far infrared material and drug therapy layer precursor; (d) adding medical oil gel to the mixture obtained in step (c) and stirring to obtain a paste-like mixture.

4. The quick-acting dysmenorrhea patch according to claim 1, characterized in that: The preparation method of saffron extract concentrate and wormwood extract concentrate is as follows: after washing and crushing saffron or wormwood, use a 70% volume fraction ethanol solution at a solid-liquid ratio of 1:10 g / mL to stir and extract at 60°C for 2 hours, filter and discard the residue, and concentrate the filtrate to 1 / 5 of the original volume at 50°C and a pressure of 0.08 MPa.

5. The quick-acting dysmenorrhea patch according to claim 1, characterized in that: The preparation method of white peony extract concentrate is as follows: after washing and crushing the white peony, ultrasonic extraction is performed at 45°C for 1 hour using a 50% volume fraction methanol solution at a solid-liquid ratio of 1:8 g / mL, and then concentrated to 1 / 5 of the original volume at 40°C and a pressure of 0.09 MPa; the ultrasonic power is 300W.

6. The quick-acting dysmenorrhea patch according to claim 1, characterized in that: The preparation method of frankincense extract and myrrh extract is as follows: after washing and crushing frankincense or myrrh, use petroleum ether with a boiling point of 60-90°C at a solid-liquid ratio of 1:12g / mL to stir and extract at room temperature for 24 hours, filter and discard the filter residue, and evaporate the filtrate to dry the petroleum ether at 70°C in an atmospheric distillation device.

7. The quick-acting dysmenorrhea patch according to claim 1, characterized in that: The preparation method of the concentrated extract of motherwort extract and the concentrated extract of chuanxiong extract is as follows: after washing and crushing the motherwort or chuanxiong, reflux extraction is carried out at 90°C for 2 hours with water at a solid-liquid ratio of 1:15g / mL, the residue is discarded after filtering, and the filtrate is concentrated to 1 / 5 of the original volume at 80°C and a pressure of 0.08MPa.

8. The quick-acting dysmenorrhea patch according to claim 2, characterized in that: When preparing the paste mixture, the raw materials are weighed according to the following weight parts: 12 parts of borneol, 5 parts of musk, 15 parts of saffron extract concentrate, 12 parts of white peony extract concentrate, 12 parts of angelica, 13 parts of frankincense extract, 13 parts of myrrh extract, 5 parts of motherwort extract concentrate, 9 parts of chuanxiong extract concentrate, 5 parts of wormwood extract concentrate, 2 parts of nano magnetic powder and 12 parts of far-infrared material; the amount of medical oil gel used is 10 parts by weight.

9. The quick-acting dysmenorrhea patch according to any one of claims 1 to 8, characterized in that: The far infrared material is high temperature bamboo charcoal powder, binchotan charcoal powder and / or far infrared ceramic powder.

10. The quick-acting dysmenorrhea patch according to claim 2, characterized in that: The carrier is silk cloth, and the thickness of the silk cloth is greater than or equal to 80g / ㎡.

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