Water-bindered pill preparation for preventing and treating urinary calculus and preparation method thereof

Abstract

The invention belongs to the technical field of anti-calculus preparations, and particularly relates to a water-bindered pill preparation for preventing and treating urinary calculus and a preparation method thereof.The water-bindered pill preparation for preventing and treating urinary calculus is prepared from 15-25 parts of mangosteen calculus substance, 5-15 parts of antibacterial and anti-inflammatory substance, 8-12 parts of calculus removing substance, 6-9 parts of preventive substance, 5-10 parts of peach gum and 5 parts of honey; mangosteen is rich in hydroxyl citric acid, high-concentration ethanol rice wine is obtained by purifying rice wine, amino acid ionic liquid is used as a catalyst, the ethanol rice wine and the amino acid ionic liquid are subjected to esterification reaction to prepare hydroxyl ethyl citrate, and after the prepared watered pill preparation is drunk by a calculus patient, the pH value of urine is adjusted and increased under the preventive alkaline condition, so that the calculus can be effectively prevented. According to the present invention, the raw materials are subjected to hydrolysis to obtain the hydroxycitric acid and the ethanol, the hydroxycitric acid decomposes the calculus, the ethanol provides the antibacterial effect, the decomposed calculus is discharged out of the body under the effect of the calculus discharging object, and the prevention object can adjust the pH value in the body so as to avoid the calculus generation;

Description

Technical Field

[0001] The invention belongs to the technical field of anti-stone preparations, and specifically refers to a water pill preparation for preventing and treating urinary system stones and a preparation method thereof. Background Art

[0002] Stones are common in the human urinary system; usually stones are formed by a mixture of various salts, and its main component is calcium oxalate. Calcium oxalate stones are relatively hard, not easy to break, rough, irregular, and mulberry-like brown in color; current clinical treatments for stones include surgical fossilization and drug fossilization. Surgical fossilization only treats the symptoms and not the root cause, is prone to recurrence, and has relatively large side effects on the human body; drug fossilization is relatively safe, has few side effects on the human body, and has become a mainstream method of stone dissolution.

[0003] There are many kinds of drugs for dissolving stones. The extract ingredients added in the preparation process of most drugs are chemical reagents and additives, which will cause certain harm to human health and the ecological environment and may pose a risk of infection; they do not conform to the green and environmentally friendly material selection concept; at the same time, most of them are difficult to eradicate or have poor treatment effects, and cannot provide post-healing prevention and treatment.

[0004] In addition, there is currently no drug on the market that takes into account multiple conditions to prepare an effective drug for preventing and treating urinary stones to meet people's needs. Summary of the invention

[0005] In view of the defects of the prior art, the present invention discloses a water pill preparation for preventing and treating urinary system stones and a preparation method thereof. Firstly, hydroxycitric acid is extracted from mangosteen and ethanol molecules in rice wine are subjected to esterification reaction under the condition of amino acid ionic liquid as a catalyst to prepare ethyl hydroxycitrate; secondly, antibacterial and anti-inflammatory components are added to ensure that bacterial infection is avoided during the treatment process; after the prepared water pill preparation is drunk, the pH of urine is adjusted under alkaline conditions to promote the rapid hydrolysis of ethyl hydroxycitrate to obtain hydroxycitric acid and ethanol, and the hydroxycitric acid decomposes stones. Finally, the stone-discharging components can be smoothly discharged from the body while ensuring the decomposition of the stones, and can prevent the formation of stones.

[0006] To achieve the above object, the technical solution adopted by the present invention is: a water pill preparation for preventing and treating urinary system stones, characterized in that it is prepared from the following raw materials in parts by weight: 15-25 parts of mangosteen stone, 5-15 parts of antibacterial and anti-inflammatory substances, 8-12 parts of stone-removing substances, 6-9 parts of preventive substances, 5-10 parts of peach gum, and 5 parts of honey;

[0007] Furthermore, the method for preparing the mangosteen fossil comprises the following steps:

[0008] M1: Weigh mangosteen, rice wine and ionic liquid in a mass ratio of 2-4:5-10:0.2, wash the mangosteen and drain it;

[0009] M2: Distill and purify the rice wine weighed in step M1 to obtain a high-concentration ethanol rice wine, crush the mangosteen, pour it into the high-concentration ethanol rice wine, and soak it at a low temperature of 2-5° C. for 48-72 hours to obtain a mixture of mangosteen and rice wine;

[0010] M3: Add water to dilute and stir the mixture of mangosteen and rice wine obtained in step M2, the volume ratio of the mixture of mangosteen and rice wine to water is 1:3-5, stir and heat at 50-70°C for 20 minutes to obtain a mangosteen and rice wine aqueous solution, add the ionic liquid weighed in step M1 to the mangosteen and rice wine aqueous solution, continue stirring and heating for 30-50 minutes, cool naturally to room temperature, and filter to obtain a mangosteen fossil solution;

[0011] M4: removing ethanol from the mangosteen fossil solution obtained in step M3 by distillation to obtain a mangosteen fossil precursor;

[0012] M5: Place the mangosteen fossil precursor obtained in step M4 into a forced air drying oven for drying and dehydration at a drying temperature of 50-70° C. for 9-15 hours, collect the powder and grind it to obtain a mangosteen fossil.

[0013] Furthermore, the preparation method of the antibacterial and anti-inflammatory substance comprises the following steps:

[0014] A1: Weigh ilex pubescens leaves, torenia repens, Polyporus umbellatus, orientalis rhizome and persimmon peel in a mass ratio of 2-4:0.5-1.5:1-3:1:1-2, wash and dry;

[0015] A2: Mix and grind the dried ilex pubescens leaves, torenia odora, umbellatum, orientalis rhizome and persimmon peel in step A1 to obtain an antibacterial and anti-inflammatory medicine package;

[0016] A3: Add the antibacterial and anti-inflammatory drug package obtained in step A2 into water and perform ultrasonic treatment. The mass ratio of the antibacterial and anti-inflammatory drug package to water is 2:3-5. The ultrasonic power is 400-600HZ. Heat and stir. The heating temperature is 80-90℃. The stirring time is 40-60min. Naturally cool to room temperature. Centrifuge and remove the residue to obtain an antibacterial and anti-inflammatory drug solution. Dry the antibacterial and anti-inflammatory drug solution in an air drying oven. The drying temperature is 60-70℃. The drying time is 12-18h. Collect the powder components and grind them to obtain antibacterial and anti-inflammatory substances.

[0017] Furthermore, the method for preparing the stone removal material comprises the following steps:

[0018] S1: Weigh mulberry root, raw chicken gizzard lining, talc, plumeria, sodium sulfate and sea sand in a mass ratio of 2-4:0.5-1.5:1:1-3:0.5-1:1-2, wash the raw chicken gizzard lining, put it into a sterilization drying oven for sterilization and drying, the drying temperature is 55-65°C, the drying time is 4-8h, grind it to obtain raw chicken gizzard lining powder, grind the talc, sodium sulfate and sea sand to obtain mixture one, wash the mulberry root and plumeria, dry it, crush it and mix it to obtain mixture two;

[0019] S2: Weighing a mixture 1 and watermelon juice in a mass ratio of 1:3-6, adding the mixture 1 to the watermelon juice, heating and stirring to dissolve, the heating temperature is 40-60° C., and the heating time is 20-30 min to obtain a mixed aqueous solution;

[0020] S3: Weigh raw chicken gizzard lining powder, mixture 2 and a mixed aqueous solution in a mass ratio of 0.5-1.5:1-2:4, add raw chicken gizzard lining powder to the mixed aqueous solution, heat and stir, the heating temperature is 75-85°C, the heating time is 2-4h, add mixture 2 obtained in step S1, heat and stir again, the heating temperature is 60-80°C, the heating time is 30-60min, cool naturally to room temperature, and filter to obtain stone-removing hydrate;

[0021] S4: drying and dehydrating the stone hydrate obtained in step S3 in a blast drying oven at a drying temperature of 55-65° C. for a drying time of 12-18 hours, collecting the powder components and grinding them to obtain a stone hydrate.

[0022] Furthermore, the method for preparing the preventive substance comprises the following steps:

[0023] P1: Weigh lemon, cucumber, carrot and carambola in a mass ratio of 0.5:2-3:1-2:6-8, wash, slice and drain the lemon, cucumber and carrot to obtain lemon slices, cucumber slices and carrot slices;

[0024] P2: washing, juicing and removing residues of the symmetrically taken carambolas to obtain carambolas juice, and diluting the juice by 2-4 times with water to obtain carambolas hydrate;

[0025] P3: The carambola hydrate obtained in step P2 is heated and stirred at a temperature of 60-80° C. The lemon slices, cucumber slices and carrot slices obtained in step P1 are added to the carambola hydrate, and boiled for 40-60 minutes. The mixture is naturally cooled to room temperature, and the residue is filtered to obtain a preventive precursor;

[0026] P4: Dry and remove water from the preventive substance precursor obtained in step P3 to obtain the preventive substance.

[0027] The present invention also provides a method for preparing a water pill preparation for preventing and treating urinary system stones, comprising the following steps:

[0028] Step 1, weigh 15-25 parts of mangosteen stone material, 5-15 parts of antibacterial and anti-inflammatory materials, 8-12 parts of stone removal materials, 6-9 parts of preventive materials, 5-10 parts of peach gum, and 5 parts of honey;

[0029] Step II, measuring water, peach gum and honey in a mass ratio of 8:5-10:5, heating and stirring evenly, the heating temperature is 50-70° C., to obtain peach gum honey hydrate, adding antibacterial and anti-inflammatory substances, stone-removing substances and preventive substances to the peach gum honey hydrate, ultrasonically stirring, raising the temperature for boiling, and naturally cooling to room temperature to obtain mixture III;

[0030] Step III, stirring the mixture obtained in step II at low temperature, adding the mangosteen fossil obtained in step I into the mixture, and rapidly stirring with a high-speed stirrer for 20-40 seconds to obtain a water pill preparation precursor;

[0031] Step VI, after the water pill preparation obtained in step III is pelletized, a freeze dryer is used to dry and remove water, the drying temperature is -40 to -20°C, the drying time is 48 to 72 hours, and the water pill preparation for preventing and treating urinary system stones is packaged.

[0032] The beneficial effects achieved by the present invention are as follows:

[0033] The water pill preparation for preventing and treating urinary system stones prepared by the present invention extracts hydroxycitric acid from mangosteen for the first time and carries out esterification reaction with ethanol molecules in rice wine, and in this process, an amino acid ionic liquid is selected as a catalyst to improve the reaction rate of the esterification reaction, and obtains a stable product ethyl hydroxycitrate; hydroxycitric acid has a good effect on dissolving stones, and rice wine is rich in ethanol molecules, which can play an antibacterial and anti-inflammatory role on the human body; at the same time, in the reaction process, an amino acid ionic liquid is selected as a catalyst for the esterification reaction, which is safe, non-toxic, and will not cause harm to human health.

[0034] The water pill preparation for preventing and treating urinary system stones prepared by the present invention is the first to add materials rich in alkaline plants as the source of alkaline materials when preparing the water pill preparation. The alkaline materials can provide the required conditions for the hydrolysis of ethyl hydroxycitrate, so that after the patient drinks the water pill preparation, ethyl hydroxycitrate is hydrolyzed to generate hydroxycitric acid and ethanol, the hydroxycitric acid dissolves the stones, and the ethanol molecules are antibacterial and anti-inflammatory, so that the stones in the human body are effectively treated. In the subsequent stone discharge process, a large amount of diuretic materials are selected to ensure that the stones after dissolution can be quickly discharged from the body without aggregation and harm to the patient. In addition, the pH value of human urine is slightly adjusted to increase, so as to prevent the generation of stones.

[0035] The water pill preparation for preventing and treating urinary system stones prepared by the present invention comprehensively considers the stone formation process from a series of angles including stone dissolving - stone expelling - stone prevention - antibacterial and anti-inflammatory for the first time. When preparing the water pill preparation, mangosteen petrifying substances, antibacterial and anti-inflammatory substances, stone expelling substances and preventive substances are respectively prepared. The hazards of stone occurrence and the conditions for their formation are analyzed from different angles, and a series of products are obtained to achieve rapid stone dissolving, stone expelling, sterilization of the process and subsequent stone prevention, accurate stone treatment, and reduction of the pain and harm of stones to the human body.

[0036] The water pill preparation for preventing and treating urinary system stones prepared by the present invention uses green, safe, non-toxic raw materials with no side effects on human health in the process of treating stones, and melons and fruits are introduced to improve the overall drinking taste of the water pill preparation. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] Figure 1 A diagram showing a preparation method according to an embodiment of the present invention;

[0038] The accompanying drawings are used to provide further understanding of the present invention and constitute a part of the specification. They are used to explain the present invention together with the embodiments of the present invention and do not constitute a limitation of the present invention. DETAILED DESCRIPTION

[0039] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments; based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0040] Unless otherwise defined, all professional and scientific terms used herein have the same meanings as those familiar to those skilled in the art. In addition, any methods and materials similar or equivalent to those described herein may be applied to the present invention. The preferred implementation methods and materials described herein are for demonstration purposes only and are not intended to limit the content of this application.

[0041] The preparation methods in the following examples are referred to Figure 1 , unless otherwise specified, are all conventional methods; the materials used in the following embodiments, unless otherwise specified, are all new materials purchased from the market, and the ionic liquid of the present invention is preferably an amino acid ionic liquid.

[0042] Example 1: A water pill preparation for preventing and treating urinary system stones, characterized in that it is prepared from the following raw materials in parts by weight: 15 parts of mangosteen stone, 5 parts of antibacterial and anti-inflammatory substances, 8 parts of stone-removing substances, 6 parts of preventive substances, 5 parts of peach gum, and 5 parts of honey;

[0043] Furthermore, the method for preparing the mangosteen fossil comprises the following steps:

[0044] M1: Weigh mangosteen, rice wine and amino acid ionic liquid in a mass ratio of 2:5:0.2, wash the mangosteen and drain it;

[0045] M2: Distill and purify the rice wine weighed in step M1 at 80° C. to obtain a high-concentration ethanol rice wine, crush the mangosteen, pour it into the high-concentration ethanol rice wine, and soak it at a low temperature of 2° C. for 48 hours to obtain a mixture of mangosteen and rice wine;

[0046] M3: dilute the mangosteen and rice wine mixture obtained in step M2 with water, wherein the volume ratio of the mangosteen and rice wine mixture to water is 1:3, heat in a water bath to 50° C. and stir for 20 min to obtain a mangosteen and rice wine aqueous solution, add the amino acid ionic liquid weighed in step M1 to the mangosteen and rice wine aqueous solution, continue to stir at the above temperature, heat for 30 min, then naturally cool to room temperature, and filter to obtain a mangosteen fossil solution;

[0047] M4: distilling the mangosteen fossil solution obtained in step M3 at 80° C. to remove the unreacted ethanol in the rice wine, thereby obtaining a mangosteen fossil precursor;

[0048] M5: Place the mangosteen fossil precursor obtained in step M4 into a forced air drying oven for drying and dehydration at a drying temperature of 50° C. for 9 hours, collect the powder and grind it through a mortar to obtain a mangosteen fossil.

[0049] Furthermore, the preparation method of the antibacterial and anti-inflammatory substance comprises the following steps:

[0050] A1: Weigh ilex pubescens leaves, torenia repens, Polyporus umbellatus, orientalis rhizome and persimmon peel in a mass ratio of 2:0.5:1:1:1, wash and dry;

[0051] A2: Mix and grind the dried ilex pubescens leaves, torenia odora, Polyporus umbellatus, orientalis rhizome and persimmon peel in step A1 to obtain an antibacterial and anti-inflammatory medicine package;

[0052] A3: Add the antibacterial and anti-inflammatory drug package obtained in step A2 into water and perform ultrasound. The mass ratio of the antibacterial and anti-inflammatory drug package to water is 2:3. The ultrasonic power is 400 Hz and the ultrasonic time is 1 hour. Then, the temperature is heated to 80°C and stirred for 40 minutes. The drug is naturally cooled to room temperature and centrifuged to remove the residue to obtain an antibacterial and anti-inflammatory drug solution. The antibacterial and anti-inflammatory drug solution is dried in a forced air drying oven at a drying temperature of 60°C for 12 hours. The powder components are collected and ground to obtain an antibacterial and anti-inflammatory substance.

[0053] Furthermore, the method for preparing the stone removal material comprises the following steps:

[0054] S1: Weigh mulberry root, raw chicken's gizzard lining, talc, plumeria, sodium sulfate and sea sand in a mass ratio of 2:0.5:1:1:0.5:1, wash the raw chicken's gizzard lining, put it into a sterilization drying oven for sterilization and drying at a drying temperature of 55°C for a drying time of 4 hours, grind it to obtain raw chicken's gizzard lining powder, mix and grind the talc, sodium sulfate and sea sand to obtain a mixture 1, wash and dry the mulberry root and plumeria, then grind and mix them in a pulverizer to obtain a mixture 2;

[0055] S2: Weighing a mixture 1 and watermelon juice in a mass ratio of 1:3, adding the mixture 1 to the watermelon juice, heating and stirring to dissolve, the heating temperature is 40° C., the heating time is 20 min, and a mixed aqueous solution is obtained;

[0056] S3: Weigh raw chicken gizzard lining powder, mixture 2 and mixed aqueous solution in a mass ratio of 0.5:1:4, add raw chicken gizzard lining powder to the mixed aqueous solution, heat and stir, the heating temperature is 75°C, the heating time is 2h, add mixture 2, then heat and stir again, the heating temperature is 60°C, the heating time is 30min, cool naturally to room temperature, and filter to obtain stone-removing hydrate;

[0057] S4: The stone removal hydrate obtained in step S3 is dried and dehydrated in a blast drying oven at a drying temperature of 55° C. for a drying time of 12 h, and the powder components are collected and ground to obtain a stone removal product.

[0058] Furthermore, the method for preparing the preventive substance comprises the following steps:

[0059] P1: Weigh lemon, cucumber, carrot and carambola in a mass ratio of 0.5:2:1:6, wash, slice and drain the lemon, cucumber and carrot to obtain lemon slices, cucumber slices and carrot slices;

[0060] P2: washing, juicing and removing residues of symmetrically taken carambolas to obtain carambola juice, which is diluted 2 times with water to obtain carambola hydrate;

[0061] P3: The carambola hydrate obtained in step P2 is heated and stirred to 60° C. The lemon slices, cucumber slices and carrot slices obtained in step P1 are added to the carambola hydrate, and the above temperature is maintained for 40 minutes. The mixture is naturally cooled to room temperature, and the residue is filtered to obtain the preventive precursor;

[0062] P4: The preventive substance precursor obtained in step P3 is dried and dehydrated in a blast drying oven at a drying temperature of 55° C. for 12 h to obtain the preventive substance.

[0063] The present invention also provides a method for preparing a water pill preparation for preventing and treating urinary system stones, comprising the following steps:

[0064] Step 1, weigh 15 parts of mangosteen fossils, 5 parts of antibacterial and anti-inflammatory substances, 8 parts of stone removal substances, 6 parts of preventive substances, 5 parts of peach gum, and 5 parts of honey;

[0065] Step II, measure water, peach gum and honey in a mass ratio of 8:5:5, heat and stir evenly, the heating temperature is 50°C, to obtain peach gum honey hydrate, add antibacterial and anti-inflammatory substances, stone removal substances and preventive substances to the peach gum honey hydrate, ultrasonicate for 30 minutes, heat to 85°C, stir and boil for 1 hour, and cool naturally to room temperature to obtain mixture III;

[0066] Step III, stirring the mixture obtained in step II at a low temperature of 5° C. for 10 min, then adding the mangosteen fossil obtained in step I into the mixture, and rapidly stirring with a high-speed stirrer at a speed of 4000 r / min for 20 s to obtain a water pill preparation precursor;

[0067] Step VI: After the water pill preparation precursor obtained in step III is made into pills with a diameter of 6 mm, a freeze dryer is used to dry and remove water at a drying temperature of -40°C for 48 hours, and the water pill preparation for preventing and treating urinary system stones is packaged.

[0068] Example 2: A water pill preparation for preventing and treating urinary system stones, characterized in that it is prepared from the following raw materials in parts by weight: 20 parts of mangosteen stone, 10 parts of antibacterial and anti-inflammatory substances, 10 parts of stone-removing substances, 7.5 parts of preventive substances, 8 parts of peach gum, and 5 parts of honey;

[0069] Furthermore, the method for preparing the mangosteen fossil comprises the following steps:

[0070] M1: Weigh mangosteen, rice wine and amino acid ionic liquid in a mass ratio of 3:8:0.2, wash the mangosteen and drain it;

[0071] M2: Distill and purify the rice wine weighed in step M1 at 80° C. to obtain a high-concentration ethanol rice wine, crush the mangosteen, pour it into the high-concentration ethanol rice wine, and soak it at a low temperature of 4° C. for 60 hours to obtain a mixture of mangosteen and rice wine;

[0072] M3: dilute the mangosteen and rice wine mixture obtained in step M2 with water, wherein the volume ratio of the mangosteen and rice wine mixture to water is 1:4, heat in a water bath to 60° C. and stir for 20 min to obtain a mangosteen and rice wine aqueous solution, add the amino acid ionic liquid weighed in step M1 to the mangosteen and rice wine aqueous solution, continue to stir at the above temperature, heat for 40 min, then naturally cool to room temperature, and filter to obtain a mangosteen fossil solution;

[0073] M4: distilling the mangosteen fossil solution obtained in step M3 at 80° C. to remove the unreacted ethanol in the rice wine, thereby obtaining a mangosteen fossil precursor;

[0074] M5: Place the mangosteen fossil precursor obtained in step M4 into a forced air drying oven for drying and dehydration at a drying temperature of 60° C. for 12 h, collect the powder and grind it through a mortar to obtain a mangosteen fossil.

[0075] Furthermore, the preparation method of the antibacterial and anti-inflammatory substance comprises the following steps:

[0076] A1: Weigh ilex pubescens leaves, torenia repens, Polyporus umbellatus, orientalis rhizome and persimmon peel in a mass ratio of 3:1:2:1:1.5, wash and dry;

[0077] A2: Mix and grind the dried ilex pubescens leaves, torenia odora, Polyporus umbellatus, orientalis rhizome and persimmon peel in step A1 to obtain an antibacterial and anti-inflammatory medicine package;

[0078] A3: Add the antibacterial and anti-inflammatory drug package obtained in step A2 into water and perform ultrasonic treatment. The mass ratio of the antibacterial and anti-inflammatory drug package to water is 2:4. The ultrasonic power is 500 Hz and the ultrasonic time is 1 hour. Then, the temperature is heated to 85°C and stirred for 50 minutes. The drug is naturally cooled to room temperature and centrifuged to remove the residue to obtain an antibacterial and anti-inflammatory drug solution. The antibacterial and anti-inflammatory drug solution is dried in a forced air drying oven at a drying temperature of 65°C and a drying time of 15 hours. The powder components are collected and ground to obtain an antibacterial and anti-inflammatory substance.

[0079] Furthermore, the method for preparing the stone removal material comprises the following steps:

[0080] S1: Weigh mulberry root, raw chicken gizzard lining, talc, plumeria, sodium sulfate and sea sand in a mass ratio of 3:1:1:2:0.8:1.5, wash the raw chicken gizzard lining, put it into a sterilization drying oven for sterilization and drying, the drying temperature is 60°C, the drying time is 6h, and the grinding process is performed to obtain raw chicken gizzard lining powder, the talc, sodium sulfate and sea sand are mixed and ground to obtain a mixture 1, and the mulberry root and plumeria are washed and dried, and then crushed and mixed by a pulverizer to obtain a mixture 2;

[0081] S2: Weighing a mixture 1 and watermelon juice in a mass ratio of 1:4.5, adding the mixture 1 to the watermelon juice, heating and stirring to dissolve, the heating temperature is 50° C., the heating time is 25 min, and a mixed aqueous solution is obtained;

[0082] S3: Weigh raw chicken gizzard lining powder, mixture 2 and mixed aqueous solution in a mass ratio of 1:1.5:4, add raw chicken gizzard lining powder to the mixed aqueous solution and heat with stirring, the heating temperature is 80°C, the heating time is 3h, add mixture 2, then heat and stir for a second time, the heating temperature is 70°C, the heating time is 45min, cool naturally to room temperature, and filter to obtain stone-removing hydrate;

[0083] S4: drying and dehydrating the stone hydrate obtained in step S3 in a blast drying oven at a drying temperature of 60° C. for 15 h, collecting the powder components and grinding them to obtain a stone hydrate.

[0084] Furthermore, the method for preparing the preventive substance comprises the following steps:

[0085] P1: Weigh lemon, cucumber, carrot and carambola in a mass ratio of 0.5:2.5:1.5:7, wash, slice and drain the lemon, cucumber and carrot to obtain lemon slices, cucumber slices and carrot slices;

[0086] P2: washing, juicing and removing residues of symmetrically taken carambolas to obtain carambola juice, which is diluted 2 times with water to obtain carambola hydrate;

[0087] P3: The carambola hydrate obtained in step P2 is heated and stirred to 70° C. The lemon slices, cucumber slices and carrot slices obtained in step P1 are added to the carambola hydrate, and the above temperature is maintained for 50 minutes, and the mixture is naturally cooled to room temperature, and the residue is filtered to obtain the preventive precursor;

[0088] P4: The preventive substance precursor obtained in step P3 is dried and dehydrated in a blast drying oven at a drying temperature of 55° C. for 12 h to obtain the preventive substance.

[0089] The present invention also provides a method for preparing a water pill preparation for preventing and treating urinary system stones, comprising the following steps:

[0090] Step 1, weigh 20 parts of mangosteen fossils, 10 parts of antibacterial and anti-inflammatory substances, 10 parts of stone removal substances, 7.5 parts of preventive substances, 8 parts of peach gum, and 5 parts of honey;

[0091] Step II, measure water, peach gum and honey in a mass ratio of 8:8:5, heat and stir evenly, the heating temperature is 60°C, to obtain peach gum honey hydrate, add antibacterial and anti-inflammatory substances, stone expelling substances and preventive substances to the peach gum honey hydrate, ultrasonicate for 30 minutes, heat to 85°C, stir and boil for 1 hour, and naturally cool to room temperature to obtain mixture III;

[0092] Step III, stirring the mixture obtained in step II at a low temperature of 5° C. for 10 min, then adding the mangosteen fossil obtained in step I into the mixture, and rapidly stirring with a high-speed stirrer at a speed of 4000 r / min for 30 s to obtain a water pill preparation precursor;

[0093] Step VI: After the water pill preparation precursor obtained in step III is made into pills with a diameter of 6 mm, a freeze dryer is used to dry and remove water at a drying temperature of -30°C for 60 hours, and the water pill preparation for preventing and treating urinary system stones is packaged.

[0094] Example 3: A water pill preparation for preventing and treating urinary system stones, characterized in that it is prepared from the following raw materials in parts by weight: 25 parts of mangosteen stone, 15 parts of antibacterial and anti-inflammatory substances, 12 parts of stone-removing substances, 9 parts of preventive substances, 10 parts of peach gum, and 5 parts of honey;

[0095] Furthermore, the method for preparing the mangosteen fossil comprises the following steps:

[0096] M1: Weigh mangosteen, rice wine and amino acid ionic liquid in a mass ratio of 4:10:0.2, wash the mangosteen and drain it;

[0097] M2: Distill and purify the rice wine weighed in step M1 at 80° C. to obtain a high-concentration ethanol rice wine, crush the mangosteen, pour it into the high-concentration ethanol rice wine, and soak it at a low temperature of 5° C. for 72 hours to obtain a mixture of mangosteen and rice wine;

[0098] M3: dilute the mangosteen and rice wine mixture obtained in step M2 with water, wherein the volume ratio of the mangosteen and rice wine mixture to water is 1:5, heat in a water bath to 70° C. and stir for 20 min to obtain a mangosteen and rice wine aqueous solution, add the amino acid ionic liquid weighed in step M1 to the mangosteen and rice wine aqueous solution, continue to stir at the above temperature, heat for 50 min, then naturally cool to room temperature, and filter to obtain a mangosteen fossil solution;

[0099] M4: distilling the mangosteen fossil solution obtained in step M3 at 80° C. to remove the unreacted ethanol in the rice wine, thereby obtaining a mangosteen fossil precursor;

[0100] M5: Place the mangosteen fossil precursor obtained in step M4 into a forced air drying oven for drying and dehydration at a drying temperature of 70° C. for 15 hours, collect the powder and grind it through a mortar to obtain a mangosteen fossil.

[0101] Furthermore, the preparation method of the antibacterial and anti-inflammatory substance comprises the following steps:

[0102] A1: Weigh ilex pubescens leaves, torenia repens, Polyporus umbellatus, orientalis rhizome and persimmon peel in a mass ratio of 4:1.5:3:1:2, wash and dry;

[0103] A2: Mix and grind the dried ilex pubescens leaves, torenia odora, Polyporus umbellatus, orientalis rhizome and persimmon peel in step A1 to obtain an antibacterial and anti-inflammatory medicine package;

[0104] A3: Add the antibacterial and anti-inflammatory drug package obtained in step A2 into water and perform ultrasound. The mass ratio of the antibacterial and anti-inflammatory drug package to water is 2:4. The ultrasonic power is 600 Hz and the ultrasonic time is 1 hour. Then, the temperature is heated to 90°C and stirred for 60 minutes. The drug is naturally cooled to room temperature and centrifuged to remove the residue to obtain an antibacterial and anti-inflammatory drug solution. The antibacterial and anti-inflammatory drug solution is dried in a forced air drying oven at a drying temperature of 70°C for 18 hours. The powder components are collected and ground to obtain an antibacterial and anti-inflammatory substance.

[0105] Furthermore, the method for preparing the stone removal material comprises the following steps:

[0106] S1: Weigh mulberry root, raw chicken gizzard lining, talc, plumeria, sodium sulfate and sea sand in a mass ratio of 4:1.5:1:3:1:2, wash the raw chicken gizzard lining, put it into a sterilization drying oven for sterilization and drying, the drying temperature is 65°C, the drying time is 8h, grind it to obtain raw chicken gizzard lining powder, mix and grind the talc, sodium sulfate and sea sand to obtain mixture 1, wash and dry the mulberry root and plumeria, and then grind and mix them in a pulverizer to obtain mixture 2;

[0107] S2: Weighing a mixture 1 and watermelon juice in a mass ratio of 1:6, adding the mixture 1 to the watermelon juice, heating and stirring to dissolve, the heating temperature is 60° C., the heating time is 30 min, and a mixed aqueous solution is obtained;

[0108] S3: Weigh raw chicken gizzard lining powder, mixture 2 and mixed aqueous solution in a mass ratio of 1.5:2:4, add raw chicken gizzard lining powder to the mixed aqueous solution and heat with stirring, the heating temperature is 85°C, the heating time is 4h, add mixture 2, then heat and stir for a second time, the heating temperature is 80°C, the heating time is 60min, cool naturally to room temperature, and filter to obtain stone-removing hydrate;

[0109] S4: drying and dehydrating the stone hydrate obtained in step S3 in a blast drying oven at a drying temperature of 65° C. for 18 h, collecting the powder components and grinding them to obtain a stone hydrate.

[0110] Furthermore, the method for preparing the preventive substance comprises the following steps:

[0111] P1: Weigh lemon, cucumber, carrot and carambola in a mass ratio of 0.5:3:2:8, wash, slice and drain the lemon, cucumber and carrot to obtain lemon slices, cucumber slices and carrot slices;

[0112] P2: washing, juicing and removing residues of symmetrically taken carambolas to obtain carambola juice, which is diluted 2 times with water to obtain carambola hydrate;

[0113] P3: The carambola hydrate obtained in step P2 is heated and stirred to 80° C. The lemon slices, cucumber slices and carrot slices obtained in step P1 are added to the carambola hydrate, and the above temperature is maintained for 60 minutes, and the mixture is naturally cooled to room temperature, and the residue is filtered to obtain the preventive precursor;

[0114] P4: The preventive substance precursor obtained in step P3 is dried and dehydrated in a blast drying oven at a drying temperature of 55° C. for 12 h to obtain the preventive substance.

[0115] The present invention also provides a method for preparing a water pill preparation for preventing and treating urinary system stones, comprising the following steps:

[0116] Step 1, weigh 25 parts of mangosteen stone, 15 parts of antibacterial and anti-inflammatory substances, 12 parts of stone removal substances, 9 parts of preventive substances, 10 parts of peach gum, and 5 parts of honey;

[0117] Step II, measure water, peach gum and honey in a mass ratio of 8:10:5, heat and stir evenly, the heating temperature is 70°C, to obtain peach gum honey hydrate, add antibacterial and anti-inflammatory substances, stone removal substances and preventive substances to the peach gum honey hydrate, ultrasonicate for 30 minutes, heat to 85°C, stir and boil for 1 hour, and cool naturally to room temperature to obtain mixture III;

[0118] Step III, stirring the mixture obtained in step II at a low temperature of 5° C. for 10 min, then adding the mangosteen fossil obtained in step I into the mixture, and rapidly stirring with a high-speed stirrer at a speed of 4000 r / min for 40 s to obtain a water pill preparation precursor;

[0119] Step VI: After the water pill preparation precursor obtained in step III is made into pills with a diameter of 6 mm, a freeze dryer is used to dry and remove water at a drying temperature of -20°C and a drying time of 72 hours, and the water pill preparation for preventing and treating urinary system stones is packaged.

[0120] The difference between Comparative Example 1 and Example 2 is that no mangosteen fossil is added, and the rest is the same as Example 2;

[0121] The difference between Comparative Example 2 and Example 2 is that no stone removal object is added, and the rest is the same as Example 2;

[0122] The difference between Comparative Example 3 and Example 2 is that no preventive agent is added, and the rest is the same as Example 2;

[0123] The difference between Comparative Example 4 and Example 2 is that no stone removal material and preventive material are added, and the rest is the same as Example 2;

[0124] The difference between Comparative Example 5 and Example 2 is that no mangosteen fossil and preventive agent are added, and the rest is the same as Example 2;

[0125] The difference between Comparative Example 6 and Example 2 is that no mangosteen fossil and stone removal material are added, and the rest is the same as Example 2;

[0126] 2 are the same;

[0127] The difference between Comparative Example 7 and Example 2 is that no mangosteen fossil, stone-removing and preventive substances are added, and the rest is the same as Example 2;

[0128] Obviously, the above comparative examples and embodiments are only a part of comparative examples and embodiments of the present invention, and they and the comparative examples and embodiments based on such references are all within the scope of protection of the present invention.

[0129] The drug usage and treatment course of the water pill preparation for preventing and treating urinary system stones prepared by the present invention are as follows:

[0130] Take the medicine half an hour after meals every morning and evening, drink three pills each time, and take it with warm boiled water; take the medicine according to the condition, one course of treatment is 2 weeks, and take 2-4 courses of treatment; for example: Patient 1 in the embodiment and Patient 1 in the comparative example are different patients, and the rest are also different patients.

[0131] Clinical trials were conducted on the water pill preparations for preventing and treating urinary system stones prepared in the examples:

[0132] Kidney stones and stones in other parts of the body with a stone size of 8-10 mm were treated as clinical trial subjects. The age of the patients was within the range of 28-40 years old. A total of 15 patients were treated. Examples 1, 2 and 3 were tested respectively. According to the above drug usage and treatment course, the symptoms of stones were checked once a week by color Doppler ultrasound. The inspection standard of the test results was: after taking the medicine, the stones were eliminated after 2-4 courses of treatment.

[0133] Table 1 shows the results of clinical trials of the water pill preparations prepared in the examples for preventing and treating urinary system stones:

[0134]

[0135] The results of clinical trials on the water pill preparations for preventing and treating urinary system stones prepared in the examples showed that the stones of the patients in Example 2 were completely eliminated after 3 courses of treatment, and the stones of the patients in Example 1 and Example 3 were also completely eliminated after 3 and 4 courses of treatment respectively; the recurrence of stones in the patients was also tracked and detected subsequently, and no stones were found in the patients' bodies after 3 months, which also showed that the obtained medicine had a good effect on the excretion of stones, and no infection occurred during the treatment process.

[0136] The water pill preparation for preventing and treating urinary system stones prepared in the comparative example was further clinically tested; kidney stones and stones in other parts of the body with a stone size of 8-10 mm were selected as clinical trial subjects, the age of the patients was in the range of 28-40 years old, a total of 14 patients were admitted, and clinical trials were conducted on the comparative example with 2 people in each group. According to the above-mentioned drug usage and treatment course, the data results of the comparative example, the symptoms of stones were checked by color ultrasound after 3 courses of treatment, and the standard for qualified test results was compared with the clinical trial results of Example 2 that the stones were completely eliminated after 3 courses of treatment.

[0137] Table 2 shows the results of the clinical trial of the water pill preparation for preventing and treating urinary system stones prepared in the comparative example:

[0138]

[0139] From the results in Table 2 above, it can be seen that the clinical trials of the water pill preparations for the prevention and treatment of urinary system stones in the comparative examples all had poor results.

[0140] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

[0141] The present invention and its implementation methods are described above, which is not restrictive. The drawings are only one of the implementation methods of the present invention, and the actual application is not limited thereto. In short, if ordinary technicians in the field are inspired by it and design methods and embodiments similar to the technical solution without creativity without departing from the purpose of the invention, they should all fall within the protection scope of the present invention.

Claims

1. A water pill preparation for preventing and treating urinary calculi, characterized in that: It is prepared from the following raw materials in parts by weight: 15-25 parts of mangosteen stone, 5-15 parts of antibacterial and anti-inflammatory substances, 8-12 parts of stone-removing substances, 6-9 parts of preventive substances, 5-10 parts of peach gum, and 5 parts of honey; The raw materials for preparing the mangosteen fossil include mangosteen, rice wine and ionic liquid, and the mass ratio of mangosteen, rice wine and ionic liquid is 2-4:5-10:0.2; The raw materials for preparing the antibacterial and anti-inflammatory substance include ilex pubescens leaves, torenia odora, Polyporus umbellatus, rhizoma alismatis and persimmon peels, wherein the mass ratio of ilex pubescens leaves, torenia odora, Polyporus umbellatus, rhizoma alismatis and persimmon peels is 2-4: 0.5-1.5:1-3:1:1-2； The raw materials for preparing the stone-removing material include mulberry root, raw chicken gizzard lining, talcum powder, frangipani, sodium sulfate, sea sand and watermelon juice; The raw materials for preparing the preventive substance include lemon, cucumber, carrot and carambola, and the mass ratio of lemon, cucumber, carrot and carambola is 0.5:2-3:1-2:6-8.

2. The water pill preparation for preventing and treating urinary system stones according to claim 1, characterized in that: The method for preparing the mangosteen fossil comprises the following steps: M1: Weigh mangosteen, rice wine and ionic liquid, wash and dry the mangosteen; M2: Distill and purify the rice wine weighed in step M1 to obtain a high-concentration ethanol rice wine, crush the mangosteen, pour it into the high-concentration ethanol rice wine, and soak it at low temperature to obtain a mixture of mangosteen and rice wine; M3: dilute the mixture of mangosteen and rice wine obtained in step M2 with water, stir and heat to obtain a mangosteen and rice wine aqueous solution, add the ionic liquid weighed in step M1 to the mangosteen and rice wine aqueous solution, continue stirring and heating, naturally cool to room temperature, and filter to obtain a mangosteen fossil solution; M4: removing ethanol from the mangosteen fossil solution obtained in step M3 by distillation to obtain a mangosteen fossil precursor; M5: Dry and remove water from the mangosteen fossil precursor obtained in step M4, collect the powder and grind it to obtain a mangosteen fossil.

3. The water pill preparation for preventing and treating urinary system stones according to claim 2, characterized in that: The low temperature in step M2 is 2-5°C, and the soaking time is 48-72h. The volume ratio of the mangosteen and rice wine mixture to water in step M3 is 1:3-5, the heating temperature is 50-70°C, and the heating time is 30-50min. The drying equipment used in step M5 is a blast drying oven, the drying temperature is 50-70°C, and the drying time is 9-15h.

4. The water pill preparation for preventing and treating urinary system stones according to claim 1, characterized in that: The preparation method of the antibacterial and anti-inflammatory substance comprises the following steps: A1: Weigh ilex pubescens leaves, torenia herba, Polyporus umbellatus, orientalis rhizome and persimmon peel, wash and dry; A2: Mix and grind the ilex pubescens leaves, torenia odora, Polyporus umbellatus, orientalis rhizome and persimmon peel prepared in step A1 to obtain an antibacterial and anti-inflammatory medicine package; A3: Add the antibacterial and anti-inflammatory drug package obtained in step A2 into water, perform ultrasonic treatment, heat and stir, naturally cool to room temperature, centrifuge to remove residue to obtain an antibacterial and anti-inflammatory drug solution, dry the antibacterial and anti-inflammatory drug solution, collect the powder components and grind them to obtain an antibacterial and anti-inflammatory substance.

5. The water pill preparation for preventing and treating urinary system stones according to claim 4, characterized in that: In step A3, the mass ratio of the antibacterial and anti-inflammatory medicine package to water is 2:3-5, the ultrasonic power is 400-600HZ, the heating temperature is 80-90°C, the stirring time is 40-60min, and the drying process is carried out in a blast drying oven, the drying temperature is 60-70°C, and the drying time is 12-18h.

6. The water pill preparation for preventing and treating urinary system stones according to claim 1, characterized in that: The method for preparing the stone removal material comprises the following steps: S1: Weigh mulberry root, raw chicken gizzard lining, talc, frangipani, sodium sulfate, sea sand and watermelon juice, wash and sterilize the raw chicken gizzard lining, dry and grind to obtain raw chicken gizzard lining powder, mix and grind the talc, sodium sulfate and sea sand to obtain mixture 1, wash and dry the mulberry root and frangipani to obtain mixture 2; S2: Weigh the mixture 1, add it into the watermelon juice, heat and stir to dissolve, and obtain a mixed aqueous solution; S3: adding the raw chicken gizzard lining powder obtained in step S1 to the mixed aqueous solution obtained in step S2, heating and stirring, adding the second mixture obtained in step S1, heating and stirring for a second time, cooling naturally to room temperature, and filtering to obtain the stone-removing hydrate; S4: Dry and remove water from the stone-removing hydrate obtained in step S3, collect the powder components and grind them to obtain a stone-removing material.

7. The water pill preparation for preventing and treating urinary system stones according to claim 6, characterized in that: The mass ratio of mulberry root, raw chicken gizzard lining, talcum powder, plumeria, sodium sulfate and sea sand in step S1 is 2-4: 0.5-1.5:1:1-3:0.5-1:1-2, sterilization and drying are carried out in a sterilization drying oven, the drying temperature is 55-65°C, and the drying time is 4-8h, the mass ratio of the mixture one and the watermelon juice in step S2 is 1:3-6, the heating temperature is 40-60°C, and the heating time is 20-30min, the mass ratio of the raw chicken gizzard powder, the mixture two and the mixed aqueous solution in step S3 is 0.5-1.5:1-2:4, the heating temperature is 75-85°C, the heating time is 2-4h, the secondary heating temperature is 60-80°C, the time is 30-60min, and the step S4 adopts a blast drying oven for drying and dehydration treatment, the drying temperature is 55-65°C, and the drying time is 12-18h.

8. The water pill preparation for preventing and treating urinary system stones according to claim 1, characterized in that: The method for preparing the preventive substance comprises the following steps: P1: Weigh lemon, cucumber, carrot and carambola, wash, slice and drain the lemon, cucumber and carrot to obtain lemon slices, cucumber slices and carrot slices; P2: washing and juicing the symmetrically taken carambolas to remove the residue to obtain carambola juice, which is diluted with water to obtain carambola hydrate; P3: The carambola hydrate obtained in step P2 is heated and stirred at a temperature of 60-80° C. The lemon slices, cucumber slices and carrot slices obtained in step P1 are added to the carambola hydrate, and boiled for 40-60 minutes. The mixture is naturally cooled to room temperature, and the residue is filtered to obtain a preventive precursor; P4: Dry and remove water from the preventive substance precursor obtained in step P3 to obtain the preventive substance.

9. A method for preparing a water pill preparation for preventing and treating urinary system stones according to any one of claims 1 to 8, characterized in that: The steps include: Step 1, weigh 15-25 parts of mangosteen stone material, 5-15 parts of antibacterial and anti-inflammatory materials, 8-12 parts of stone removal materials, 6-9 parts of preventive materials, 5-10 parts of peach gum, and 5 parts of honey; Step II, measuring water, peach gum and honey, heating and stirring evenly to obtain peach gum honey hydrate, adding antibacterial and anti-inflammatory substances, stone-removing substances and preventive substances to the peach gum honey hydrate, stirring ultrasonically, heating up the temperature for boiling, and naturally cooling to room temperature to obtain mixture III; Step III, stirring the mixture obtained in step II at low temperature, adding the mangosteen fossil obtained in step I into the mixture and stirring rapidly to obtain a water pill preparation precursor; Step VI, drying and dehydrating the water pill preparation obtained in step III after pilling, and packaging to obtain the water pill preparation for preventing and treating urinary system stones.

10. The method for preparing a water pill preparation for preventing and treating urinary system stones according to claim 9, characterized in that: The mass ratio of water, peach gum and honey in step II is 8:5-10:5, the heating temperature is 50-70°C, the rapid stirring in step III adopts a high-speed stirrer, the stirring time is 20-40s, and the step VI adopts a freeze dryer for drying and dehydration, the drying temperature is -40 to -20°C, and the drying time is 48-72h.

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