Hair loss preventing and hair strengthening composition as well as preparation method and application thereof

Abstract

The invention discloses an anti-hair loss and hair strengthening composition as well as a preparation method and application thereof. The composition is prepared from the following components in parts by weight: 10 to 20 parts of a lysimachia christinae extract, 10 to 20 parts of a ginkgo biloba extract, 10 to 30 parts of a poria cocos extract, 8 to 16 parts of a cacumen biotae extract, 7 to 12 parts of a radix angelicae sinensis extract, 7 to 12 parts of a radix polygoni multiflori extract, 5 to 10 parts of a herba menthae extract, 1 to 15 parts of squalane, 0.3 to 5 parts of adenosine, 20 to 70 parts of butanediol and 30 to 250 parts of water. The anti-hair loss and hair strengthening composition provided by the invention can stimulate hair follicles, promote hair growth, improve hair quality and reduce hair loss, and has a relatively good application prospect in hair products.

Description

Technical Field

[0001] The invention relates to the technical field of daily cosmetics, and in particular to an anti-hair loss and hair solidifying composition and a preparation method and application thereof. Background Art

[0002] Affected by genetics, inflammation, environment and other factors, hair loss is difficult to completely eradicate and has become a problem that troubles many consumers. Moreover, hair loss is no longer limited to the elderly, but has become a major problem that troubles people's physical and mental health.

[0003] Hair loss is divided into physiological hair loss and pathological hair loss. Pathological hair loss includes alopecia areata, psychogenic hair loss, endocrine disorder hair loss, seborrheic alopecia, etc. At present, there are a large number of anti-hair loss and hair growth products on the market, but most of them are found to have limited effects after use, and they do not completely improve the problem of hair loss, and even breed other hair problems. The products on the market have poor stability of raw material formulas, resulting in poor actual efficacy, or unreasonable formulas and strong irritation, causing scalp allergies, itching, oily hair, dandruff and other problems. Of course, there are also pure Chinese medicine formula ingredients with higher safety, but pure Chinese medicine ingredients will have the problem of poor effect or slow effect.

[0004] Therefore, it is necessary to develop anti-hair loss and hair solidification products that are more effective, gentler and safer to meet the needs of people with hair loss. Summary of the invention

[0005] The purpose of the present invention is to provide an anti-hair loss and hair solidifying composition and a preparation method and application thereof. The composition has excellent effects of promoting hair follicle hair growth and improving hair quality, can strengthen and toughen hair, and significantly reduce the frequency of hair loss and hair shedding.

[0006] To this end, the present invention adopts the following technical solutions:

[0007] The invention provides an anti-hair loss and hair solidifying composition, comprising the following components in parts by weight: 10-20 parts of Lychnophora scabra extract, 10-20 parts of Ginkgo biloba extract, 10-30 parts of Poria cocos extract, 8-16 parts of Platycladus orientalis leaf extract, 7-12 parts of Angelica sinensis extract, 7-12 parts of Polygonum multiflorum extract, 5-10 parts of peppermint extract, 1-15 parts of squalane, 0.3-5 parts of adenosine, 20-70 parts of butylene glycol and 30-150 parts of water.

[0008] Preferably, it further comprises 10-20 parts of Atractylodes lancea rhizome extract and / or 10-20 parts of Campanula variegata bark extract.

[0009] Preferably, it further comprises 1-7 parts of Rosa canina fruit oil and / or 1-7 parts of Verbena oil.

[0010] Preferably, it further comprises 0.1-1.5 parts of dihydrosphingosine.

[0011] Furthermore, the preparation method of the Lychnophora extract comprises the following steps:

[0012] (1) crushing the dried Lychnos nucifera and passing through a 30-80 mesh to obtain Lychnos nucifera powder;

[0013] (2) immersing the Lychnophora powder obtained in step (1) in ethanol, ultrasonicating for 0.5-1 h, and separating the filtrate and the residue;

[0014] (3) dissolving the filter residue obtained in step (2) with a 0-10% by mass ethanol solution, heating in a water bath for a period of time under reflux, and separating the filtrate and the filter residue to obtain an extract 1;

[0015] (4) dissolving the filter residue obtained in step (3) in an ethanol solution having a mass fraction of 15-30%, heating in a water bath under reflux for a period of time, separating the filtrate and the filter residue to obtain extract 2;

[0016] (5) dissolving the filter residue obtained in step (4) in an ethanol solution having a mass fraction of 35-50%, heating in a water bath under reflux for a period of time, separating the filtrate and the filter residue to obtain extract 3;

[0017] (6) The filtrate, extract 1, extract 2 and extract 3 obtained in step (2) are combined, and the combined solution is concentrated to 1 / 3 to 1 / 4 of the original volume, and dried to obtain a Lychnophora scabra extract.

[0018] Preferably, in step (3), the heating temperature is 75-95°C, and the extraction time is 1-3h; and / or, in step (4), the heating temperature is 70-90°C, and the extraction time is 1-3h; and / or, in step (5), the heating temperature is 70-90°C, and the extraction time is 1-3h.

[0019] The present invention also provides a method for preparing the anti-hair loss and hair-fixing composition, comprising the following steps: weighing various raw materials according to a proportion, and mixing and stirring the various components evenly to obtain the composition.

[0020] The present invention further provides an application of the anti-hair loss and hair solidifying composition in hair products.

[0021] Preferably, the amount of the anti-hair loss and hair solidifying composition added to the hair product is 5-30 wt%.

[0022] Preferably, the hair products include shampoo, conditioner, shampoo cream, essence

[0023] Compared with the prior art, the present invention has the following beneficial effects:

[0024] The anti-hair loss and hair solidifying composition of the present invention adopts a scientific ratio of lychnophora extract, ginkgo extract, Poria extract, Platycladus orientalis leaf extract, angelica extract, Polygonum multiflorum extract, peppermint extract, Atractylodes lancea rhizome extract, Campanula variegata bark extract, squalane and adenosine, and has excellent effects of promoting hair follicle growth, reducing hair loss and strengthening hair roots.

[0025] The anti-hair loss and hair-fixing composition of the present invention can promote scalp blood circulation, increase hair follicle nutrition, promote hair growth, enhance hair elasticity and toughness, and prevent hair breakage and shedding. Lychnophora scabra extract, variegated bellflower bark, and Atractylodes macrocephala rhizome extract can work together to regulate the scalp microenvironment, improve essential problems such as greasiness, hair follicle blockage, and bacterial growth, and improve the scalp's ability to absorb nutrients. Further combined with plant extract active ingredients such as ginkgo extract, Poria cocos extract, Platycladus orientalis leaf extract, Angelica sinensis extract, Polygonum multiflorum extract, and peppermint extract, the hair obtains rich nutrients, improves hair growth, repairs damaged hair, makes the hair thicker and tougher, and is not easy to break or fall.

[0026] The Lychnophora camphora extract provided by the present invention is extracted by alcohol extraction, and the filter residue is extracted in sequence from low to high alcohol concentrations, so as to obtain a higher content of active ingredients that effectively promote hair growth and hair fixation. When combined with other ingredients in the composition of the present invention, it can act synergistically to play a more significant role in stimulating hair follicle production, improving hair quality, enhancing hair toughness, and significantly reducing the extent of hair loss.

[0027] The anti-hair loss and hair solidifying composition of the present invention is mild and non-irritating, has obvious effects, and has good application prospects in hair care and growth products. DETAILED DESCRIPTION

[0028] Below by specific embodiment, the specific implementation mode of this explanation technical scheme is further described, these embodiments are for the detailed description of this technical scheme, rather than for limiting this technical scheme. Based on the embodiment in this description, all other embodiments obtained by those of ordinary skill in the art without making creative work premise belong to the scope of protection of this description. Unless otherwise specified, the reagent, method and equipment used in the present invention are conventional reagents, methods and equipment in the art, and the reagents and materials used in the following examples are all commercially available.

[0029] Preparation Example 1

[0030] This preparation example provides a method for preparing a Lychnophora extract, comprising the following steps:

[0031] (1) crushing the dried Lychnos nucifera and passing through a 60-mesh filter to obtain Lychnos nucifera powder;

[0032] (2) immersing the Lychnophora powder obtained in step (1) in ethanol, ultrasonicating for 1 h, and separating the filtrate and the residue;

[0033] (3) dissolving the filter residue obtained in step (2) in a 5% by mass ethanol solution, heating under reflux in a water bath for 2 h at a heating temperature of 85° C., separating the filtrate and the filter residue to obtain an extract 1;

[0034] (4) dissolving the filter residue obtained in step (3) in an ethanol solution with a mass fraction of 20%, heating under reflux in a water bath for 1.5 h at a heating temperature of 85° C., separating the filtrate and the filter residue to obtain extract 2;

[0035] (5) dissolving the filter residue obtained in step (4) in an ethanol solution with a mass fraction of 50%, heating under reflux in a water bath for 1 h at a heating temperature of 85° C., separating the filtrate and the filter residue to obtain extract 3;

[0036] (6) The filtrate, extract 1, extract 2 and extract 3 obtained in step (2) are combined, and the combined solution is concentrated to 1 / 4 of the original volume, and dried to obtain Lycopodiella ciliata extract A.

[0037] Preparation Example 2

[0038] This preparation example provides a method for preparing a Lychnophora extract, comprising the following steps:

[0039] (1) crushing the dried Lychnos nucifera and passing through a 60-mesh filter to obtain Lychnos nucifera powder;

[0040] (2) immersing the Lychnophora powder obtained in step (1) in ethanol, ultrasonicating for 1 h, and separating the filtrate and the residue;

[0041] (3) dissolving the filter residue obtained in step (2) in water, heating under reflux in a water bath for 2 h at a heating temperature of 90° C., separating the filtrate and the filter residue to obtain extract 1;

[0042] (4) dissolving the filter residue obtained in step (3) in an ethanol solution with a mass fraction of 20%, heating under reflux in a water bath for 1.5 h at a heating temperature of 85° C., separating the filtrate and the filter residue to obtain extract 2;

[0043] (5) dissolving the filter residue obtained in step (4) in an ethanol solution with a mass fraction of 50%, heating under reflux in a water bath for 1 h at a heating temperature of 85° C., separating the filtrate and the filter residue to obtain extract 3;

[0044] (6) The filtrate, extract 1, extract 2 and extract 3 obtained in step (2) are combined, and the combined solution is concentrated to 1 / 4 of the original volume, and dried to obtain Lycopodiella ciliata extract B.

[0045] Example 1

[0046] A hair loss prevention and hair solidification composition comprises the following components in parts by weight: 15 parts of Lycopodiella ciliata extract A, 10 parts of Ginkgo biloba extract, 15 parts of Poria cocos extract, 10 parts of Platycladus orientalis leaf extract, 8 parts of Angelica sinensis extract, 10 parts of Polygonum multiflorum extract, 7 parts of peppermint extract, 13 parts of Atractylodes lancea rhizome extract, 13 parts of Campanula variegata bark extract, 5 parts of squalane, 1 part of adenosine, 20 parts of butylene glycol and 180 parts of water.

[0047] Example 2

[0048] A hair loss prevention and hair solidification composition comprises the following components in parts by weight: 15 parts of Lychnophora scabra extract B, 10 parts of Ginkgo biloba extract, 15 parts of Poria cocos extract, 15 parts of Platycladus orientalis leaf extract, 10 parts of Angelica sinensis extract, 12 parts of Polygonum multiflorum extract, 9 parts of peppermint extract, 15 parts of Atractylodes lancea rhizome extract, 13 parts of Campanula variegata bark extract, 5 parts of squalane, 1 part of adenosine, 30 parts of butylene glycol and 200 parts of water.

[0049] Example 3

[0050] A hair loss prevention and hair solidification composition comprises the following components in parts by weight: 20 parts of Lychnophora scabra extract B, 10 parts of Ginkgo biloba extract, 20 parts of Poria cocos extract, 15 parts of Platycladus orientalis leaf extract, 10 parts of Angelica sinensis extract, 12 parts of Polygonum multiflorum extract, 9 parts of peppermint extract, 10 parts of Atractylodes lancea rhizome extract, 15 parts of Campanula variegata bark extract, 10 parts of squalane, 5 parts of adenosine, 50 parts of butylene glycol and 200 parts of water.

[0051] Example 4

[0052] A hair loss prevention and hair solidification composition comprises the following components in parts by weight: 10 parts of Lychnophora scabra extract B, 15 parts of Ginkgo biloba extract, 15 parts of Poria cocos extract, 15 parts of Platycladus orientalis leaf extract, 10 parts of Angelica sinensis extract, 12 parts of Polygonum multiflorum extract, 9 parts of peppermint extract, 10 parts of Atractylodes lancea rhizome extract, 10 parts of Campanula variegata bark extract, 3 parts of squalane, 5 parts of adenosine, 35 parts of butylene glycol and 200 parts of water.

[0053] Example 5

[0054] A hair loss prevention and hair solidification composition comprises the following components in parts by weight: 20 parts of Lychnophora scabra extract A, 20 parts of Ginkgo biloba extract, 15 parts of Poria cocos extract, 12 parts of Platycladus orientalis leaf extract, 8 parts of Angelica sinensis extract, 12 parts of Polygonum multiflorum extract, 7 parts of peppermint extract, 15 parts of Atractylodes macrocephala rhizome extract, 15 parts of Campanula variegata bark extract, 10 parts of squalane, 2 parts of adenosine, 50 parts of butylene glycol and 200 parts of water.

[0055] Example 6

[0056] A hair loss prevention and hair solidification composition comprises the following components in parts by weight: 20 parts of Lycopodiella ciliata extract B, 10 parts of Ginkgo biloba extract, 20 parts of Poria cocos extract, 15 parts of Platycladus orientalis leaf extract, 10 parts of Angelica sinensis extract, 12 parts of Polygonum multiflorum extract, 9 parts of peppermint extract, 10 parts of Atractylodes lancea rhizome extract, 15 parts of Campanula variegata bark extract, 10 parts of squalane, 5 parts of adenosine, 5 parts of Rosa canina fruit oil, 3 parts of Verbena oil, 50 parts of butylene glycol and 192 parts of water.

[0057] Example 7

[0058] A hair loss prevention and hair solidification composition comprises the following components in parts by weight: 20 parts of Lycopodiella ciliata extract B, 10 parts of Ginkgo biloba extract, 20 parts of Poria cocos extract, 15 parts of Platycladus orientalis leaf extract, 10 parts of Angelica sinensis extract, 12 parts of Polygonum multiflorum extract, 9 parts of peppermint extract, 10 parts of Atractylodes macrocephala rhizome extract, 15 parts of Campanula variegata bark extract, 10 parts of squalane, 5 parts of adenosine, 5 parts of Rosa canina fruit oil, 3 parts of verbena oil, 0.5 parts of dihydrosphingosine, 50 parts of butylene glycol and 191.5 parts of water.

[0059] Comparative Example 1

[0060] Compared with Example 3, the difference is that no Lychnophora extract is added, and the other aspects are the same.

[0061] Comparative Example 2

[0062] Compared with Example 3, the difference is that no Lychnophora lychnophora extract and Atractylodes lancea rhizome extract are added, and the other parts are the same.

[0063] Comparative Example 3

[0064] Compared with Example 3, the difference is that no Lychnophora scabra extract and Campanula variegata bark extract are added, and the other parts are the same.

[0065] Comparative Example 4

[0066] Compared with Example 3, the difference is that: no Lychnophora scabra extract, Atractylodes macrocephala rhizome extract, and Campanula variegata bark extract are added, and the others are the same.

[0067] Comparative Example 5

[0068] Compared with Example 3, the difference is that no Lychnophora lychnophora extract and Platycladus orientalis leaf extract are added, and the other parts are the same.

[0069] Comparative Example 6

[0070] Compared with Example 3, the difference is that: no Lychnophora lychnophora extract, Platycladus orientalis leaf extract, and Polygonum multiflorum extract are added, and the rest are the same.

[0071] Comparative Example 7

[0072] Compared with Example 3, the difference is that: no Lychnophora lychnophora extract, Platycladus orientalis leaf extract, Polygonum multiflorum extract, and Poria cocos extract are added, and the rest are the same.

[0073] Comparative Example 8

[0074] Compared with Example 3, the difference is that the preparation method of the Lychnophora scabra extract is different, and the others are the same.

[0075] Preparation method of Lychnophora extract: dissolve Lychnophora powder in 8 times volume of water, extract under water bath reflux at 80°C for 3h, concentrate and dry to obtain the extract.

[0076] Comparative Example 9

[0077] Compared with Example 3, the difference is that the preparation method of the Lychnophora scabra extract is different, and the others are the same.

[0078] The preparation method of Lychnophora extract is as follows: dissolve Lychnophora powder with 8 times the volume of 90% ethanol by mass, extract under reflux in a water bath at 80°C for 3 hours, concentrate and dry to obtain the extract.

[0079] The preparation method of the anti-hair loss and hair solidifying composition of Examples 1-7 and Comparative Examples 1-9 is as follows: weigh the raw materials according to the proportions, mix the components and stir them to mix evenly to obtain the anti-hair loss and hair solidifying compositions.

[0080] Application Examples

[0081] An anti-hair loss and hair solidifying essence comprises 10% of an anti-hair loss and hair solidifying composition, 5% of propylene glycol, 0.3% of PEG-40 hydrogenated castor oil, 0.5% of phenoxyethanol and the balance of water.

[0082] The anti-hair loss and hair solidifying composition is selected from the compositions of Examples 1-7 and Comparative Examples 1-9.

[0083] In order to verify the anti-hair loss and hair solidifying effect of the composition of the present invention, the following tests were performed:

[0084] (I) Safety testing

[0085] The compositions prepared in all the above examples and comparative examples were subjected to human safety patch tests. The test method was based on the human skin patch test in the "2015 Cosmetic Safety Technical Specifications". The method of the skin occlusion patch test was as follows: 80 people aged 30-55 years old were selected, 5 in each group, and the selected area was no more than 50mm 2, a qualified spot test device with a depth of about 1mm, take 0.020mL of the composition prepared in the above examples and comparative examples and put it into the small chamber of the spot tester, the control well is a blank control (no substance is placed), the spot tester with the anti-hair loss and hair-fixing composition is applied to the curved side of the forearm of the subject with a low-allergenic tape, and the palm is gently pressed to make it evenly applied to the skin, and it lasts for 24 hours. Observe the skin reaction according to the standards in Table 1 30 minutes after removing the spot tester (after the indentation disappears), 24 hours and 48 hours respectively, and record the observation results.

[0086] Table 1 Observation criteria

[0087]

[0088]

[0089] The experimental results showed no positive reaction, and all the compositions prepared in the examples and comparative examples passed the human patch safety test, indicating that the anti-hair loss and hair solidifying composition of the present invention is safe, without any adverse reaction.

[0090] (II) Efficacy test

[0091] 1. Mouse hair growth test

[0092] Take 180 Wistar rats of half male and half female, with similar weight and hair growth, and divide them into 170 modeling groups and 10 blank control groups. The area of ​​3cm×3cm was selected from the same position on the back of the rat and dyed yellow with 3% picric acid solution as the test area. Except for the control group, the mice in other groups were subcutaneously injected with testosterone propionate (1mg / kg"d dose) once a day for 60 consecutive days behind the neck, and then depilated and marked the test area. The mice after modeling were randomly divided into 17 groups, 10 in each group, corresponding to Examples 1-7 and Comparative Examples 1-9, and minoxidil groups, and then the anti-hair loss and hair-fixing compositions prepared by Examples 1-7 and Comparative Examples 1-9 and 2% minoxidil solutions were applied to the test area every day, and each sample was applied 2mL each time. The changes in the skin on the back of the mice and the hair growth were observed daily. The blank group was not treated after depilation. After 30 days, 10 longer hairs were randomly selected from the test area for each group of experimental mice, and their lengths were measured with a vernier caliper. The hair in the test area was collected and weighed, and the test results were statistically analyzed. The average value was taken, and it was observed whether the hair in the test area of ​​the mice appeared sparse or messy. The test results are shown in Table 2.

[0093] Table 2 Effects of the composition on hair growth in mice

[0094]

[0095]

[0096] As can be seen from Table 2, compared with the comparative example, the minoxidil group and the blank group, the rats in the Example 1-7 groups of the present invention have longer hair growth, heavier hair, smoother hair growth and better glossiness. This indicates that the anti-hair loss and hair-fixing composition provided by the present invention has a more significant effect of promoting hair growth in rats.

[0097] Compared with Example 3, Comparative Example 1 did not add the Lychnophora scabra extract, and the average hair length and average hair weight were lower, and the glossiness was lighter.

[0098] Compared with Example 3, Comparative Example 2 did not add the Lychnophora scabra extract and the Atractylodes lancea rhizome extract, and the average hair length and average hair weight were lower, the glossiness was lighter, and it was slightly worse than Comparative Example 1.

[0099] Compared with Example 3, Comparative Example 3 did not add the Lychnophora scabra extract and the Campanula variegata bark extract, and the average hair length and average hair weight were lower, the glossiness was lighter, and it was slightly worse than Comparative Example 1.

[0100] Compared with Example 3, Comparative Example 4 did not add Lychnophora oxyphylla extract, Atractylodes lancea rhizome extract, and Campanula variegata bark extract, and the average hair length and average hair weight were lower, the hair gloss was significantly worse than that of Comparative Example 1, indicating that the simultaneous addition of Lychnophora oxyphylla extract, Atractylodes lancea rhizome extract, and Campanula variegata bark extract can act synergistically to improve hair growth, and the lack of any one of them will reduce the effect of promoting hair growth.

[0101] Compared with Example 3, Comparative Example 5 did not add the Lychnophora lychnophora extract and Platycladus orientalis leaf extract, and the average hair length and average hair weight were lower, the glossiness was lighter, and it was slightly worse than Comparative Example 1.

[0102] Compared with Example 3, Comparative Example 6 did not add the Lychnophora lychnophora extract, Platycladus orientalis leaf extract, and Polygonum multiflorum extract, and the average hair length and average hair weight were lower, the glossiness was lighter, and it was slightly worse than Comparative Example 5.

[0103] Compared with Example 3, Comparative Example 7 did not add Lychnophora cucullata extract, Platycladus orientalis leaf extract, Polygonum multiflorum extract, and Poria cocos extract, and the average hair length and average hair weight were lower, the hair was dull, and was significantly worse than that of Comparative Example 6, indicating that the simultaneous presence of Lychnophora cucullata extract, Platycladus orientalis leaf extract, Polygonum multiflorum extract, and Poria cocos extract can work together to better promote hair growth.

[0104] Compared with Example 3, the preparation methods of the Lychnophora extracts in Comparative Examples 8 and 9 are different, and the average hair length and average hair weight are both lower, and the glossiness is lighter, indicating that the preparation method of the Lychnophora extract provided by the present invention, the active ingredients obtained have a more significant effect of promoting hair production.

[0105] 2. Anti-hair loss efficacy test

[0106] (1) Selection of subjects

[0107] Eligible subjects were selected according to the inclusion and exclusion criteria, and divided into the experimental group and the control group according to the random table, ensuring that the final number of effective cases was no less than 20 people / group.

[0108] Inclusion criteria: 25-50 years old, healthy men or women, after the subjects were stratified by age, the subjects of the same age group were randomly divided into experimental groups and control groups. The hair length was between 5 and 40 cm, with the problem of hair loss and mild hair thinning, and the hair loss count was more than 10 after 60 combing and still more than 10 after 2 weeks of washing; no special hair treatments such as hair dyeing, perming, and styling in the past month; able to understand the experimental process, voluntarily participate in the experiment and sign the written informed consent.

[0109] Exclusion criteria: pregnant or breastfeeding women, or those who are planning to get pregnant in the near future; patients with severe androgenic alopecia, alopecia areata, inflammatory cicatricial alopecia or other scalp / hair diseases; patients with psychiatric or psychological diseases; or those with long-term sleep or mood control disorders; those who have used cosmetics with anti-hair loss effects or other products with such effects or hair growth effects in the past 3 months; those who have taken or topically applied any drugs that affect hair growth in the past 6 months; those who have received hair transplant treatment; those with curly hair; those with highly sensitive constitutions; those who have participated in other clinical trials in the past 2 months; those who are considered unsuitable for participation in the trial by clinical assessment.

[0110] Subject restrictions: Subjects are not allowed to comb their own hair on the day of the visit; no haircut is allowed within 2 weeks before each visit assessment during the trial; no hair care or hairdressing treatments can be performed during the trial, and no anti-hair loss or hair growth treatments can be received; during the trial, the original lifestyle habits must be maintained and emotional fluctuations must be avoided.

[0111] (2) Test method: 320 subjects were selected, including 200 males and 120 females. After the subjects were stratified by age, the subjects of the same age group were randomly divided into experimental groups and control groups, and divided into 17 groups. The sample (including the anti-hair loss and hair strengthening essence of the embodiment or comparative example) was applied to the hair loss area of ​​the scalp after washing, about 5 g each time, 3 times a week, and each test substance was used for at least 8 weeks.

[0112] (3) Hair loss count: During each visit, the subjects' hair was combed 60 times, the number of lost hairs was counted and the average value was taken for each group and recorded in Table 3; the calculation method of the change range is: hair loss reduction rate = (number of lost hairs before use - number of lost hairs after use) / number of lost hairs before use * 100%.

[0113] Table 3 Improvement of hair loss by anti-hair loss essence

[0114]

[0115]

[0116] As can be seen from Table 3, the anti-hair loss and hair-fixing composition obtained by the technical solution of the present invention has an excellent effect of preventing hair loss, and the amount of hair loss after 8 weeks of use is reduced by 45-57.14% compared with the amount of hair loss before use. And it is significantly higher than the reduction of 23.53-43.75% in the amount of hair loss in comparative examples 1-7.

[0117] Therefore, the anti-hair loss and hair solidifying composition provided by the present invention has the functions of promoting hair growth, strengthening hair roots, and reducing hair loss, and has a good application prospect in preventing hair loss and hair solidifying.

[0118] Although the embodiments of the present description have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present description, the scope of which is defined by the appended claims and their equivalents.

Claims

1. An anti-hair loss and hair solidifying composition, characterized in that: The invention comprises the following components in parts by weight: 10-20 parts of Lycopodiella ciliata extract, 10-20 parts of Ginkgo biloba extract, 10-30 parts of Poria cocos extract, 8-16 parts of Platycladus orientalis leaf extract, 7-12 parts of Angelica sinensis extract, 7-12 parts of Polygonum multiflorum extract, 5-10 parts of peppermint extract, 1-15 parts of squalane, 0.3-5 parts of adenosine, 20-70 parts of butylene glycol and 30-250 parts of water.

2. The anti-hair loss and hair solidifying composition according to claim 1, characterized in that: The invention also comprises 10-20 parts of rhizome extract of Atractylodes lancea and / or 10-20 parts of bark extract of Campanula variegata.

3. The anti-hair loss and hair solidifying composition according to claim 2, characterized in that: The invention also contains 1-7 parts of dog rose fruit oil and / or 1-7 parts of verbena oil.

4. The anti-hair loss and hair solidifying composition according to claim 3, characterized in that: It also contains 0.1-1.5 parts of dihydrosphingosine.

5. The anti-hair loss and hair solidifying composition according to claim 1, characterized in that: The preparation method of the Lychnophora quinata extract comprises the following steps: (1) crushing the dried Lychnos nucifera and passing through a 30-80 mesh to obtain Lychnos nucifera powder; (2) immersing the Lychnophora powder obtained in step (1) in ethanol, ultrasonicating for 0.5-1 h, and separating the filtrate and the residue; (3) dissolving the filter residue obtained in step (2) in an ethanol solution with a mass fraction of 0-10%, heating in a water bath and refluxing for a period of time, separating the filtrate and the filter residue to obtain an extract 1; (4) dissolving the filter residue obtained in step (3) in an ethanol solution having a mass fraction of 15-30%, heating in a water bath under reflux for a period of time, separating the filtrate and the filter residue to obtain extract 2; (5) dissolving the filter residue obtained in step (4) in an ethanol solution having a mass fraction of 35-50%, heating in a water bath under reflux for a period of time, separating the filtrate and the filter residue to obtain extract 3; (6) The filtrate, extract 1, extract 2 and extract 3 obtained in step (2) are combined, and the combined solution is concentrated to 1 / 3 to 1 / 4 of the original volume, and dried to obtain a Lychnophora scabra extract.

6. The anti-hair loss and hair solidifying composition according to claim 5, characterized in that: In the step (3), the heating temperature is 75-95°C and the extraction time is 1-3h; and / or, in the step (4), the heating temperature is 70-90°C and the extraction time is 1-3h; and / or, in the step (5), the heating temperature is 70-90°C and the extraction time is 1-3h.

7. The method for preparing the anti-hair loss and hair solidifying composition according to any one of claims 1 to 6, characterized in that: The method comprises the following steps: weighing various raw materials according to the proportion, and mixing and stirring various components evenly to obtain the product.

8. Use of the anti-hair loss and hair solidifying composition according to any one of claims 1 to 7 in hair products.

9. The use according to claim 8, characterized in that: The amount of the anti-hair loss and hair solidifying composition added to hair products is 5-30wt%.

10. The use according to claim 8, characterized in that: The hair products include shampoo, hair conditioner, shampoo cream and essence.

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