Enzymolysis tank for extracting heparin

Abstract

The invention discloses an enzymolysis tank for heparin extraction, and relates to the technical field of enzymolysis tank equipment.The enzymolysis tank comprises a tank body and a control device, and the tank body is provided with a feeding part electrically connected with the control device; the enzymolysis tank for heparin extraction further comprises a partition plate fixedly arranged in the tank body, an enzymolysis mechanism arranged on the partition plate, a filtering mechanism arranged in the enzymolysis space, a discharging part arranged on the tank body and a discharging part arranged on the tank body. The device is provided with the enzymolysis mechanism, so that a heparin raw material is in full contact with an enzyme solution, meanwhile, the situation that the heparin raw material is wound on an enzymolysis frame in the enzymolysis process, so that the heparin raw material wound on the enzymolysis frame cannot be in full contact with the enzyme solution is avoided, and meanwhile, a sliding cutting block which slides in a reciprocating manner also facilitates cutting of the heparin raw material; therefore, the contact area between the heparin raw material and the enzyme solution is further increased, and the extraction effect of the device on heparin is further improved.

Description

Technical Field

[0001] The invention relates to the technical field of enzymolysis tank equipment, in particular to an enzymolysis tank for heparin extraction. Background Art

[0002] Heparin is a mucopolysaccharide with different molecular lengths produced by mast cells in animal connective tissue. It has natural anticoagulant properties. Since it was first used in clinical practice as an anticoagulant in 1935, it has been the most common anticoagulant in clinical practice. At present, industrial heparin is mainly extracted from pig intestines. Due to the difficulty in quality control and the inherent high heterogeneity of pig intestinal heparin, researchers have been studying anticoagulant drugs to replace heparin and its oligosaccharides. However, due to its complex structure, cumbersome synthesis steps and low product yield, related research on the chemical production of heparin and its oligosaccharides has not yielded any results. Heparin is still the main anti-thrombotic and anti-coagulant drug in clinical medicine.

[0003] Currently, heparin extraction mostly uses pig intestines as the raw material for heparin extraction and then uses corresponding enzyme solutions to extract heparin. When the current heparin extraction equipment is extracting heparin, the pig intestines are easily entangled on the stirring parts in the extraction equipment, which makes it impossible for the pig intestines to fully contact with the enzyme solution, thereby greatly reducing the extraction effect of the extraction equipment on heparin. Therefore, improvement is urgently needed. Summary of the invention

[0004] In view of the deficiencies in the prior art, the object of the present invention is to provide an enzymatic hydrolysis tank for heparin extraction, aiming to solve the above technical problems.

[0005] In order to achieve the above object, the present invention adopts the following technical solutions:

[0006] An enzymolysis tank for heparin extraction comprises a tank body and a control device, wherein the control device is detachably fixedly connected to the tank body, a leg is fixedly arranged on the tank body, and a feeding part electrically connected to the control device is arranged on the tank body. The enzymolysis tank for heparin extraction further comprises:

[0007] A partition is fixedly arranged in the tank body, and the partition divides the interior of the tank body into a transmission space and an enzymolysis space;

[0008] An enzymatic hydrolysis mechanism, disposed on the partition and electrically connected to the control device, the enzymatic hydrolysis mechanism being used to assist in extracting heparin from the heparin raw material in the enzymatic hydrolysis space;

[0009] A filtering mechanism, located in the enzymatic hydrolysis space, the filtering mechanism is arranged on the partition, the filtering mechanism is electrically connected to the control device, and the filtering mechanism is used to filter the heparin raw material after enzymatic hydrolysis;

[0010] A discharge part, arranged on the tank body, for discharging the heparin raw material processed by the filtering mechanism out of the tank body;

[0011] The discharge part is arranged on the tank body and is electrically connected to the control device. The discharge part is used to discharge the enzyme solution containing heparin out of the tank body.

[0012] Preferably, the feeding section comprises:

[0013] A feed pipe is fixedly arranged on the tank body and is connected with the enzymolysis space;

[0014] A first material control valve, which is arranged on the feed pipe and is electrically connected to the control device, and is used to control the connection and closing of the feed pipe and the enzymatic hydrolysis space;

[0015] The feed hopper is fixedly arranged on the feed pipe.

[0016] Preferably, the enzymatic hydrolysis mechanism comprises:

[0017] A power unit, disposed on the partition and electrically connected to the control device;

[0018] A bearing part, disposed on the power part, and used for transmitting power output by the power part;

[0019] The enzymatic hydrolysis parts have two groups, and both groups of enzymatic hydrolysis parts are arranged on the supporting part, and the enzymatic hydrolysis parts are used to stir the heparin raw materials in the enzymatic hydrolysis space.

[0020] Preferably, the power unit comprises:

[0021] An enzymatic hydrolysis motor is disposed on the partition and is detachably fixedly connected to the partition, and the enzymatic hydrolysis motor is electrically connected to the control device;

[0022] A rotating shaft is disposed on the partition and is rotatably connected to the partition, and one end of the rotating shaft close to the enzymatic hydrolysis motor is fixedly connected to the output end of the enzymatic hydrolysis motor;

[0023] The connecting sleeve is arranged at one end of the rotating shaft away from the enzymatic hydrolysis motor and is fixedly connected to the rotating shaft.

[0024] Preferably, the bearing portion comprises:

[0025] A bearing shaft, disposed on the connecting sleeve and detachably fixedly connected to the connecting sleeve;

[0026] There are two groups of longitudinal grooves, and both groups of longitudinal grooves are opened on the load-bearing shaft. The longitudinal grooves are provided with receiving grooves, and the receiving grooves are provided with engaging springs fixedly connected to the load-bearing shaft. The ends of the engaging springs close to the longitudinal grooves are fixedly provided with engaging balls;

[0027] The baffle is arranged at one end of the bearing shaft away from the connecting sleeve and is fixedly connected to the bearing shaft.

[0028] Preferably, the enzymatic hydrolysis unit comprises:

[0029] A fixing rod, disposed in the longitudinal groove and fixedly connected to the bearing shaft;

[0030] A rotating block, rotatably disposed on the fixed rod;

[0031] A connecting rod, fixedly arranged on the rotating block;

[0032] An enzymolysis frame is arranged at one end of the connecting rod away from the fixed rod and fixedly connected to the connecting rod, and a snap-fitting groove for cooperating with the snap-fitting ball is provided on the enzymolysis frame;

[0033] A counterweight block is arranged at one end of the enzymolysis frame away from the fixed rod and is fixedly connected to the enzymolysis frame, and the counterweight block is used to drive the enzymolysis frame to rotate out of the longitudinal groove;

[0034] A built-in rod is fixedly arranged in the enzymolysis frame, a sliding block is slidably arranged on the built-in rod, a ball is rollingly arranged on the sliding block, two symmetrical enzymolysis springs are sleeved on the built-in rod, and the two ends of the enzymolysis springs are respectively fixedly connected to the enzymolysis frame and the sliding block.

[0035] Preferably, the filtering mechanism comprises:

[0036] There are multiple hydraulic push rods, and the multiple hydraulic push rods are evenly arranged on the partition plate, and the hydraulic push rods are electrically connected to the control device;

[0037] There are multiple pull rods, and the multiple pull rods are respectively arranged on adjacent hydraulic push rods;

[0038] An annular plate, fixedly arranged at one end of the pull rod away from the partition;

[0039] A filter plate, disposed on the annular plate and fixedly connected to the annular plate;

[0040] The extrusion part is located in the enzymatic hydrolysis space and is used for extruding the heparin raw material on the filter plate.

[0041] Preferably, the extrusion portion comprises:

[0042] There are multiple support plates, and the multiple support plates are evenly distributed on the inner surface of the tank body;

[0043] There are multiple extrusion springs, and the multiple extrusion springs are fixedly arranged on the surface of the partition close to the enzymolysis space;

[0044] An extrusion plate, fixedly arranged at one end of the extrusion spring away from the partition, the partition is rotatably connected to the bearing shaft, and the extrusion plate is used to squeeze the heparin raw material on the filter plate;

[0045] There are multiple hanging plates, and the multiple hanging plates are fixedly arranged on the surface of the extrusion plate close to the partition plate. The hanging plates are used to cooperate with the supporting plates to suspend the extrusion plate.

[0046] Preferably, the discharge part comprises:

[0047] A discharge port is provided on the tank body, and an arc-shaped groove is provided in the discharge port;

[0048] An arc-shaped door is slidably disposed in the arc-shaped groove;

[0049] A fixing block is arranged on a surface of the arc door away from the axis of the tank body, and the fixing block is fixedly connected to the arc door.

[0050] Preferably, the discharging portion comprises:

[0051] A discharge pipe is arranged on the tank body, the discharge pipe is communicated with the enzymolysis space, and the discharge pipe is used to discharge the enzyme solution containing heparin from the tank body;

[0052] The second material control valve is arranged on the discharge pipe and is electrically connected to the control device, and is used to control the connection and closing of the discharge pipe and the enzymatic hydrolysis space.

[0053] In summary, due to the adoption of the above technical solution, the beneficial effects of the present invention are:

[0054] 1. The device is provided with an enzymatic hydrolysis mechanism, so that the heparin raw material is in full contact with the enzyme solution, and at the same time, the heparin raw material is prevented from being entangled on the enzymatic hydrolysis frame during the enzymatic hydrolysis process, resulting in the heparin raw material being entangled on the enzymatic hydrolysis frame and not being able to fully contact with the enzyme solution. At the same time, the reciprocating sliding cutter also facilitates the chopping of the heparin raw material, thereby further increasing the contact area between the heparin raw material and the enzyme solution, and further improving the extraction effect of the device on heparin.

[0055] 2. The device is provided with a filtering mechanism, so that the device can squeeze the heparin raw material after enzymatic hydrolysis, thereby squeezing out the enzyme solution containing heparin adsorbed by the heparin raw material, avoiding the waste of the enzyme solution containing heparin and improving the extraction effect of heparin to a certain extent. BRIEF DESCRIPTION OF THE DRAWINGS

[0056] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other accompanying drawings can be obtained based on these accompanying drawings without paying creative work.

[0057] Figure 1 A schematic diagram of the three-dimensional structure of an enzymatic hydrolysis tank for heparin extraction is shown.

[0058] Figure 2 A front view of an enzymatic hydrolysis tank for heparin extraction is shown.

[0059] Figure 3 A side view of an enzymatic hydrolysis tank for heparin extraction is shown.

[0060] Figure 4 Shows Figure 3 Sectional view of AA.

[0061] Figure 5 Shows Figure 4 A schematic diagram of the enlarged local structure at point A in the middle.

[0062] Figure 6 A top view of an enzymatic hydrolysis tank for heparin extraction is shown.

[0063] Figure 7 The figure shows a schematic diagram of the internal structure of an enzymatic hydrolysis tank for heparin extraction.

[0064] Figure 8 An exploded view of a partial structure of an enzymatic hydrolysis tank for heparin extraction is shown.

[0065] Fig. 9 Shows Figure 8 Exploded view of the middle part of the structure.

[0066] Fig.10 Shows Fig. 9 A magnified schematic diagram of the local structure at point B in the middle.

[0067] Fig.11 An exploded view of the enzymatic hydrolysis section is shown.

[0068] Legend:

[0069] 1. Tank; 2. Control device; 3. Legs; 4. Partition; 5. Transmission space; 6. Enzyme hydrolysis space; 7. Feed pipe; 8. First material control valve; 9. Feed hopper; 10. Enzyme hydrolysis motor; 11. Rotating shaft; 12. Connecting sleeve; 13. Bearing shaft; 14. Longitudinal groove; 15. Accommodating groove; 16. Clamping spring; 17. Clamping ball; 18. Baffle; 19. Fixed rod; 20. Rotating block; 21. Connecting rod; 22. Enzyme hydrolysis Frame; 23, snap-fit ​​groove; 24, counterweight; 25, built-in rod; 26, sliding cutter; 27, ball bearing; 28, enzymatic hydrolysis spring; 29, hydraulic push rod; 30, pull rod; 31, annular plate; 32, filter plate; 33, support plate; 34, extrusion spring; 35, extrusion plate; 36, hanging plate; 37, discharge port; 38, arc groove; 39, arc door; 40, fixed block; 41, discharge pipe; 42, second material control valve. DETAILED DESCRIPTION

[0070] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0071] In the description of the present invention, it should be understood that the terms "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside" and "outside" etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0072] It should be noted that when a component is referred to as being "fixed to" another component, it may be directly on the other component or there may also be a component centered. When a component is considered to be "connected to" another component, it may be directly connected to the other component or there may also be a component centered. When a component is considered to be "set on" another component, it may be directly set on the other component or there may also be a component centered. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are for illustrative purposes only.

[0073] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0074] Reference Figures 1 to 11 , an enzymatic hydrolysis tank embodiment for heparin extraction of the present invention is further described.

[0075] An enzymolysis tank for heparin extraction comprises a tank body 1 and a control device 2, wherein the control device 2 is detachably fixedly connected to the tank body 1, a leg 3 is fixedly arranged on the tank body 1, and a feeding part electrically connected to the control device 2 is arranged on the tank body 1, wherein the feeding part comprises:

[0076] A feed pipe 7 is fixedly arranged on the tank body 1 and is connected to the enzymolysis space 6;

[0077] A first material control valve 8 is provided on the feed pipe 7 and is electrically connected to the control device 2. The first material control valve 8 is used to control the connection and closing of the feed pipe 7 and the enzymatic hydrolysis space 6;

[0078] The feed hopper 9 is fixedly arranged on the feed pipe 7 .

[0079] During operation, the first material control valve 8 is opened by the control device 2, and then the heparin raw material and the corresponding enzyme solution are sequentially fed into the enzymatic hydrolysis space 6 through the feed hopper 9 and the feed pipe 7, so as to facilitate the subsequent extraction of heparin from the heparin raw material.

[0080] The enzymatic hydrolysis tank for heparin extraction also includes:

[0081] A partition 4 is fixedly disposed in the tank body 1, and the partition 4 divides the interior of the tank body 1 into a transmission space 5 and an enzymolysis space 6;

[0082] An enzymatic hydrolysis mechanism, which is disposed on the partition 4 and is electrically connected to the control device 2, and is used to assist in extracting heparin from the heparin raw material in the enzymatic hydrolysis space 6;

[0083] Reference Figures 1 to 11 , the enzymatic hydrolysis mechanism comprises:

[0084] A power unit, which is disposed on the partition plate 4 and is electrically connected to the control device 2;

[0085] The power unit comprises:

[0086] The enzymatic hydrolysis motor 10 is disposed on the partition 4 and is detachably fixedly connected to the partition 4. The enzymatic hydrolysis motor 10 is electrically connected to the control device 2;

[0087] A rotating shaft 11 is disposed on the partition 4 and is rotatably connected to the partition 4. One end of the rotating shaft 11 close to the enzymatic hydrolysis motor 10 is fixedly connected to the output end of the enzymatic hydrolysis motor 10.

[0088] The connecting sleeve 12 is disposed at one end of the rotating shaft 11 away from the enzymatic hydrolysis motor 10 and is fixedly connected to the rotating shaft 11 .

[0089] A bearing part, disposed on the power part, and used for transmitting power output by the power part;

[0090] The bearing portion comprises:

[0091] The bearing shaft 13 is disposed on the connecting sleeve 12 and is detachably fixedly connected to the connecting sleeve 12;

[0092] There are two groups of longitudinal grooves 14, and both groups of longitudinal grooves 14 are opened on the bearing shaft 13. The longitudinal grooves 14 are provided with receiving grooves 15. The receiving grooves 15 are provided with engaging springs 16 fixedly connected to the bearing shaft 13. The engaging springs 16 are fixedly provided with engaging balls 17 at the ends of the engaging springs 16 close to the longitudinal grooves 14.

[0093] The baffle 18 is disposed at one end of the bearing shaft 13 away from the connecting sleeve 12 and is fixedly connected to the bearing shaft 13 .

[0094] The enzymatic hydrolysis parts have two groups, and the two groups of enzymatic hydrolysis parts are both arranged on the supporting part, and the enzymatic hydrolysis parts are used to stir the heparin raw materials in the enzymatic hydrolysis space 6;

[0095] The enzymatic hydrolysis unit comprises:

[0096] A fixing rod 19 is disposed in the longitudinal groove 14 and fixedly connected to the bearing shaft 13;

[0097] A rotating block 20 is rotatably disposed on the fixing rod 19;

[0098] A connecting rod 21 is fixedly disposed on the rotating block 20;

[0099] The enzymolysis frame 22 is arranged at one end of the connecting rod 21 away from the fixing rod 19 and is fixedly connected to the connecting rod 21. The enzymolysis frame 22 is provided with a snap-fitting groove 23 for cooperating with the snap-fitting ball 17.

[0100] Reference Figures 1 to 11The control device 2 is used to control the start of the enzymolysis motor 10, so that the rotating shaft 11 fixedly connected to the output end of the enzymolysis motor 10 rotates, and then the connecting sleeve 12 fixedly connected to the rotating shaft 11 rotates, thereby driving the load-bearing shaft 13 connected to the connecting sleeve 12 to rotate, so that the fixed rod 19 arranged on the load-bearing shaft 13 rotates around the axis of the load-bearing shaft 13, and then drives the rotating block 20 rotatably connected to the fixed rod 19 to rotate around the axis of the load-bearing shaft 13, so that the connecting rod 21 fixedly connected to the rotating block 20 drives the enzymolysis frame 22 to rotate around the axis of the load-bearing shaft 13, thereby stirring the heparin raw material in the enzyme solution in the enzymolysis space 6, thereby facilitating the extraction of heparin in the heparin raw material and improving the heparin extraction effect of the device.

[0101] A counterweight block 24 is disposed at one end of the enzymolysis frame 22 away from the fixing rod 19 and is fixedly connected to the enzymolysis frame 22. The counterweight block 24 is used to drive the enzymolysis frame 22 to rotate out of the longitudinal groove 14.

[0102] It should be noted that by providing a counterweight 24, the process of facilitating the enzymatic hydrolysis frame 22 to rotate out of the longitudinal groove 14 is specifically as follows: the enzymatic hydrolysis motor 10 is started by the control device 2. When the rotation speed of the enzymatic hydrolysis motor 10 reaches a certain rotation speed, the counterweight 24 fixedly connected to the enzymatic hydrolysis frame 22 moves in a direction away from the axis of the load-bearing shaft 13 under the action of centrifugal force, thereby rotating the enzymatic hydrolysis frame 22 fixedly connected to the counterweight 24 out of the longitudinal groove 14.

[0103] The built-in rod 25 is fixedly arranged in the enzymolysis frame 22, and a sliding block 26 is slidably arranged on the built-in rod 25, and a ball 27 is rollingly arranged on the sliding block 26. Two symmetrical enzymolysis springs 28 are sleeved on the built-in rod 25, and the two ends of the enzymolysis spring 28 are fixedly connected to the enzymolysis frame 22 and the sliding block 26 respectively.

[0104] When the enzymatic hydrolysis frame 22 rotates around the axis of the load-bearing shaft 13, the speed of the enzymatic hydrolysis motor 10 is controlled by the control device 2, so that the centrifugal force exerted on the sliding block 26 in the enzymatic hydrolysis frame 22 changes, and the force applied by the sliding block 26 to the enzymatic hydrolysis springs 28 on both sides changes, so that the enzymatic hydrolysis springs 28 on both sides are deformed, so that the sliding block 26 can slide back and forth on the built-in rod 25 while rotating around the axis of the load-bearing shaft 13, thereby avoiding the heparin raw material from being entangled in the enzymatic hydrolysis frame 22 during the enzymatic hydrolysis process, resulting in the heparin raw material entangled in the enzymatic hydrolysis frame 22 cannot be fully contacted with the enzyme solution, and the reciprocating sliding block 26 also facilitates the chopping of the heparin raw material.

[0105] The device is provided with an enzymatic hydrolysis mechanism, so that the heparin raw material is in full contact with the enzyme solution, and at the same time, it also prevents the heparin raw material from being entangled on the enzymatic hydrolysis frame 22 during the enzymatic hydrolysis process, resulting in the heparin raw material entangled on the enzymatic hydrolysis frame 22 not being able to fully contact with the enzyme solution. At the same time, the reciprocating sliding cutter 26 also facilitates the chopping of the heparin raw material, thereby further increasing the contact area between the heparin raw material and the enzyme solution, and further improving the heparin extraction effect of the device.

[0106] Reference Figures 1 to 11 , a filtering mechanism, located in the enzymatic hydrolysis space 6, the filtering mechanism is arranged on the partition 4, the filtering mechanism is electrically connected to the control device 2, and the filtering mechanism is used to filter the heparin raw material after enzymatic hydrolysis;

[0107] The filtering mechanism comprises:

[0108] There are multiple hydraulic push rods 29, and the multiple hydraulic push rods 29 are evenly arranged on the partition 4, and the hydraulic push rods 29 are electrically connected to the control device 2;

[0109] There are multiple pull rods 30, and the multiple pull rods 30 are respectively arranged on adjacent hydraulic push rods 29;

[0110] The annular plate 31 is fixedly arranged at one end of the pull rod 30 away from the partition plate 4;

[0111] The filter plate 32 is disposed on the annular plate 31 and is fixedly connected to the annular plate 31;

[0112] An extrusion unit, located in the enzymatic hydrolysis space 6, for extruding the heparin raw material on the filter plate 32;

[0113] The extrusion portion comprises:

[0114] There are multiple support plates 33, and the multiple support plates 33 are evenly distributed on the inner surface of the tank body 1;

[0115] There are multiple extrusion springs 34, and the multiple extrusion springs 34 are fixedly arranged on the surface of the partition plate 4 close to the enzymatic hydrolysis space 6;

[0116] The squeezing plate 35 is fixedly arranged at one end of the squeezing spring 34 away from the partition plate 4, the partition plate 4 is rotatably connected to the bearing shaft 13, and the squeezing plate 35 is used to squeeze the heparin raw material on the filter plate 32;

[0117] There are multiple hanging plates 36 , and the multiple hanging plates 36 are fixedly disposed on the surface of the extrusion plate 35 close to the partition plate 4 . The hanging plates 36 are used to cooperate with the support plate 33 to suspend the extrusion plate 35 .

[0118] Reference Figures 1 to 11After the heparin in the heparin raw material is extracted, the enzymolysis motor 10 is turned off by the control device 2 and the hydraulic push rod 29 is started at the same time, so that the hydraulic push rod 29 contracts, so that the pull rod 30 fixedly connected to the hydraulic push rod 29 moves toward the direction of the partition 4, and then the annular plate 31 fixedly connected to the pull rod 30 drives the filter plate 32 to move toward the direction of the partition 4. In the process of the filter plate 32 moving toward the partition 4, the heparin raw material in the enzyme solution is also filtered out and the filtered heparin raw material is driven to move toward the direction of the partition 4 until the filter plate 32 contacts the extrusion plate 35 and pushes the extrusion plate 35 to move toward the direction of the partition 4, so that the extrusion spring 34 fixedly connected to the extrusion plate 35 is compressed, so that the extrusion spring 34 applies a certain force to the extrusion plate 35, so that the extrusion plate 35 applies a certain force to the filter plate 32, thereby squeezing the heparin raw material on the filter plate 32, and then the enzyme solution containing heparin adsorbed by the heparin raw material is squeezed out and flows into the enzyme solution containing heparin below the filter plate 32 through the filter plate 32.

[0119] The device is provided with a filtering mechanism, so that the device can extrude the heparin raw material after enzymatic hydrolysis, thereby squeezing out the enzyme solution containing heparin adsorbed by the heparin raw material, avoiding the waste of the enzyme solution containing heparin and improving the extraction effect of heparin to a certain extent.

[0120] Reference Figures 1 to 11 , a discharge part, which is arranged on the tank body 1 and is used to discharge the heparin raw material processed by the filtering mechanism out of the tank body 1;

[0121] The discharge part comprises:

[0122] A discharge port 37 is provided on the tank body 1, and an arc-shaped groove 38 is provided in the discharge port 37;

[0123] An arc-shaped door 39 is slidably disposed in the arc-shaped groove 38;

[0124] The fixing block 40 is disposed on a surface of the arc door 39 away from the axis of the tank body 1 , and the fixing block 40 is fixedly connected to the arc door 39 .

[0125] After the enzyme solution containing heparin adsorbed by the heparin raw material is completely squeezed out, the staff pushes the arc door 39 to slide in the arc groove 38 through the fixed block 40, so that subsequent staff can discharge the squeezed heparin raw material into the tank body 1 through the discharge port 37.

[0126] A discharge part, which is arranged on the tank body 1 and is electrically connected to the control device 2, and is used to discharge the enzyme solution containing heparin out of the tank body 1;

[0127] The discharging part comprises:

[0128] A discharge pipe 41 is disposed on the tank body 1, the discharge pipe 41 is connected to the enzymatic hydrolysis space 6, and the discharge pipe 41 is used to discharge the enzyme solution containing heparin from the tank body 1;

[0129] The second material control valve 42 is disposed on the discharge pipe 41 and is electrically connected to the control device 2 , and is used to control the connection and closing of the discharge pipe 41 and the enzymatic hydrolysis space 6 .

[0130] After the squeezed heparin raw material is discharged from the tank body 1 , the second material control valve 42 is controlled to open by the control device 2 , so that the enzyme solution containing heparin in the enzymatic hydrolysis space 6 is discharged from the tank body 1 .

[0131] Working principle: Refer to Figures 1 to 11 When working, the first material control valve 8 is controlled to open by the control device 2, and then the heparin raw material and the corresponding enzyme solution are sequentially fed into the enzymolysis space 6 through the feed hopper 9 and the feed pipe 7, and then the enzymolysis motor 10 is controlled to start by the control device 2, so that the rotating shaft 11 fixedly connected to the output end of the enzymolysis motor 10 rotates, and then the connecting sleeve 12 fixedly connected to the rotating shaft 11 rotates, thereby driving the bearing shaft 13 connected to the connecting sleeve 12 to rotate, so that the fixed rod 19 arranged on the bearing shaft 13 rotates around the axis of the bearing shaft 13, and then drives the rotating block 20 rotatably connected to the fixed rod 19 to rotate around the axis of the bearing shaft 13, so that the connecting rod 21 fixedly connected to the rotating block 20 drives the enzymolysis frame 22 to rotate around the axis of the bearing shaft 13, thereby stirring the heparin raw material in the enzyme solution in the enzymolysis space 6, thereby facilitating the extraction of heparin from the heparin raw material, and improving the heparin extraction effect of the device;

[0132] When the enzymolysis frame 22 rotates around the axis of the bearing shaft 13, the speed of the enzymolysis motor 10 is controlled by the control device 2, so that the centrifugal force on the sliding block 26 in the enzymolysis frame 22 changes, and then the force applied by the sliding block 26 to the enzymolysis springs 28 on both sides changes, so that the enzymolysis springs 28 on both sides are deformed, so that the sliding block 26 can slide back and forth on the built-in rod 25 while rotating around the axis of the bearing shaft 13, thereby avoiding the heparin raw material from being entangled in the enzymolysis frame 22 during the enzymolysis process, resulting in the heparin raw material entangled in the enzymolysis frame 22 cannot be fully contacted with the enzyme solution, and the reciprocating sliding block 26 also facilitates the chopping of the heparin raw material, so that the heparin raw material can be fully contacted with the enzyme solution, which greatly improves the extraction effect of the device on heparin;

[0133] After the heparin in the heparin raw material is extracted, the enzymolysis motor 10 is turned off by the control device 2 and the hydraulic push rod 29 is started at the same time, so that the hydraulic push rod 29 contracts, so that the pull rod 30 fixedly connected to the hydraulic push rod 29 moves toward the direction of the partition 4, and then the annular plate 31 fixedly connected to the pull rod 30 drives the filter plate 32 to move toward the direction of the partition 4. In the process of the filter plate 32 moving toward the partition 4, the heparin raw material in the enzyme solution is also filtered out and the filtered heparin raw material is driven to move toward the direction of the partition 4 until the filter plate 32 contacts the extrusion plate 35 and pushes the extrusion plate 35 to move toward the direction of the partition 4, so that the filter plate 32 contacts the extrusion plate 35 and pushes the extrusion plate 35 to move toward the direction of the partition 4, so that the filter plate 31 fixedly connected to the extrusion plate 31 drives the filter plate 32 to move toward the partition 4. The fixedly connected extrusion spring 34 is compressed, so that the extrusion spring 34 applies a certain force to the extrusion plate 35, so that the extrusion plate 35 applies a certain force to the filter plate 32, thereby extruding the heparin raw material on the filter plate 32, and then the enzyme solution containing heparin adsorbed by the heparin raw material is squeezed out and flows into the enzyme solution containing heparin below the filter plate 32 through the filter plate 32. After the enzyme solution containing heparin adsorbed by the heparin raw material is completely squeezed out, the staff pushes the arc door 39 to slide in the arc groove 38 through the fixed block 40, so that the subsequent staff can discharge the squeezed heparin raw material into the tank body 1 through the discharge port 37;

[0134] After the squeezed heparin raw material is discharged from the tank body 1 , the second material control valve 42 is controlled to open by the control device 2 , so that the enzyme solution containing heparin in the enzymatic hydrolysis space 6 is discharged from the tank body 1 .

[0135] It should be noted that, in the process of the filter plate 32 moving toward the partition plate 4, the filter plate 32 pushes the enzymolysis frame 22 to rotate around the fixing rod 19 until the enzymolysis frame 22 is rotated into the longitudinal groove 14. In the process of the enzymolysis frame 22 being rotated into the longitudinal groove 14, the surface of the enzymolysis frame 22 close to the snap-fit ​​ball 17 applies pressure to the snap-fit ​​ball 17, so that the snap-fit ​​ball 17 squeezes the snap-fit ​​spring 16 to slide into the receiving groove 15. After the enzymolysis frame 22 completely slides into the longitudinal groove 14, the compressed snap-fit ​​spring 16 releases its elastic potential energy to squeeze the snap-fit ​​ball 17. 7 is pushed in the direction of the engaging groove 23 until the engaging ball 17 slides into the engaging groove 23, thereby fixing the enzymolysis frame 22 in the longitudinal groove 14. The specific process of rotating the enzymolysis frame 22 out of the longitudinal groove 14 is as follows: the enzymolysis motor 10 is controlled to start by the control device 2. When the rotation speed of the enzymolysis motor 10 reaches a certain rotation speed, the counterweight block 24 fixedly connected to the enzymolysis frame 22 moves in the direction away from the axis of the load-bearing shaft 13 under the action of centrifugal force, thereby rotating the enzymolysis frame 22 fixedly connected to the counterweight block 24 out of the longitudinal groove 14.

[0136] The above description of the embodiments enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but will conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. An enzymatic hydrolysis tank for heparin extraction, comprising a tank body (1) and a control device (2), wherein the control device (2) is detachably fixedly connected to the tank body (1), and a support leg (3) is fixedly provided on the tank body (1), characterized in that: The tank body (1) is provided with a feeding portion electrically connected to the control device (2), and the enzymatic hydrolysis tank for heparin extraction further comprises: A partition (4) is fixedly arranged in the tank body (1), and the partition (4) divides the interior of the tank body (1) into a transmission space (5) and an enzymolysis space (6); an enzymatic hydrolysis mechanism, which is disposed on the partition (4) and is electrically connected to the control device (2), and is used to assist in extracting heparin from the heparin raw material in the enzymatic hydrolysis space (6); A filtering mechanism is located in the enzymatic hydrolysis space (6), the filtering mechanism is arranged on the partition (4), the filtering mechanism is electrically connected to the control device (2), and the filtering mechanism is used to filter the heparin raw material after enzymatic hydrolysis; A discharge portion, arranged on the tank body (1), for discharging the heparin raw material processed by the filtering mechanism out of the tank body (1); The discharge portion is arranged on the tank body (1) and is electrically connected to the control device (2). The discharge portion is used to discharge the enzyme solution containing heparin out of the tank body (1).

2. The enzymolysis tank for heparin extraction according to claim 1, characterized in that: The feeding part comprises: A feed pipe (7) is fixedly mounted on the tank body (1), and the feed pipe (7) is in communication with the enzymolysis space (6); A first material control valve (8), which is arranged on the feed pipe (7) and is electrically connected to the control device (2), and the first material control valve (8) is used to control the connection and closing of the feed pipe (7) and the enzymatic hydrolysis space (6); The feed hopper (9) is fixedly arranged on the feed pipe (7).

3. The enzymolysis tank for heparin extraction according to claim 2, characterized in that: The enzymatic hydrolysis mechanism comprises: A power unit, which is arranged on the partition (4) and is electrically connected to the control device (2); A bearing part, disposed on the power part, and used for transmitting power output by the power part; The enzymatic hydrolysis parts have two groups, and both groups of enzymatic hydrolysis parts are arranged on the supporting part. The enzymatic hydrolysis parts are used to stir the heparin raw material in the enzymatic hydrolysis space (6).

4. The enzymatic hydrolysis tank for heparin extraction according to claim 3, characterized in that: The power unit comprises: an enzymatic hydrolysis motor (10), which is disposed on the partition (4) and is detachably fixedly connected to the partition (4); the enzymatic hydrolysis motor (10) is electrically connected to the control device (2); A rotating shaft (11) is disposed on the partition (4) and is rotatably connected to the partition (4); one end of the rotating shaft (11) close to the enzymatic hydrolysis motor (10) is fixedly connected to the output end of the enzymatic hydrolysis motor (10); The connecting sleeve (12) is arranged at one end of the rotating shaft (11) away from the enzymatic hydrolysis motor (10), and is fixedly connected to the rotating shaft (11).

5. The enzymatic hydrolysis tank for heparin extraction according to claim 4, characterized in that: The bearing portion comprises: A bearing shaft (13) is disposed on the connecting sleeve (12) and is detachably fixedly connected to the connecting sleeve (12); There are two groups of longitudinal grooves (14), and both groups of longitudinal grooves (14) are opened on the bearing shaft (13). A receiving groove (15) is opened in the longitudinal groove (14), and a clamping spring (16) fixedly connected to the bearing shaft (13) is arranged in the receiving groove (15). A clamping ball (17) is fixedly arranged at the end of the clamping spring (16) close to the longitudinal groove (14); The baffle (18) is arranged at one end of the bearing shaft (13) away from the connecting sleeve (12) and is fixedly connected to the bearing shaft (13).

6. The enzymatic hydrolysis tank for heparin extraction according to claim 5, characterized in that: The enzymatic hydrolysis unit comprises: A fixing rod (19) is disposed in the longitudinal groove (14) and fixedly connected to the bearing shaft (13); A rotating block (20) is rotatably mounted on the fixing rod (19); A connecting rod (21) fixedly disposed on the rotating block (20); An enzymatic hydrolysis frame (22) is arranged at one end of the connecting rod (21) away from the fixed rod (19) and is fixedly connected to the connecting rod (21). The enzymatic hydrolysis frame (22) is provided with a snap-fitting groove (23) that cooperates with the snap-fitting ball (17); A counterweight (24) is arranged at one end of the enzymolysis frame (22) away from the fixed rod (19) and is fixedly connected to the enzymolysis frame (22). The counterweight (24) is used to drive the enzymolysis frame (22) to rotate out of the longitudinal groove (14); A built-in rod (25) is fixedly arranged in the enzymolysis frame (22); a sliding block (26) is slidably arranged on the built-in rod (25); a ball (27) is rollably arranged on the sliding block (26); two symmetrical enzymolysis springs (28) are sleeved on the built-in rod (25); two ends of the enzymolysis spring (28) are respectively fixedly connected to the enzymolysis frame (22) and the sliding block (26).

7. The enzymatic hydrolysis tank for heparin extraction according to claim 6, characterized in that: The filtering mechanism comprises: A plurality of hydraulic push rods (29) are evenly arranged on the partition plate (4), and the hydraulic push rods (29) are electrically connected to the control device (2); There are multiple pull rods (30), and the multiple pull rods (30) are respectively arranged on adjacent hydraulic push rods (29); An annular plate (31) is fixedly arranged on an end of the pull rod (30) away from the partition plate (4); A filter plate (32) is disposed on the annular plate (31) and is fixedly connected to the annular plate (31); The extrusion part is located in the enzymatic hydrolysis space (6) and is used for extruding the heparin raw material on the filter plate (32).

8. The enzymolysis tank for heparin extraction according to claim 7, characterized in that: The extrusion portion comprises: A plurality of support plates (33) are provided, and the plurality of support plates (33) are evenly distributed on the inner surface of the tank body (1); A plurality of extrusion springs (34) are provided, and the plurality of extrusion springs (34) are fixedly arranged on the surface of the partition plate (4) close to the enzymatic hydrolysis space (6); An extrusion plate (35) is fixedly arranged at one end of the extrusion spring (34) away from the partition plate (4), the partition plate (4) is rotatably connected to the bearing shaft (13), and the extrusion plate (35) is used to extrude the heparin raw material on the filter plate (32); There are a plurality of hanging plates (36), and the plurality of hanging plates (36) are fixedly arranged on the surface of the extrusion plate (35) close to the partition plate (4), and the hanging plates (36) are used to cooperate with the support plate (33) to suspend the extrusion plate (35).

9. The enzymatic hydrolysis tank for heparin extraction according to claim 8, characterized in that: The discharge part comprises: A discharge port (37) is provided on the tank body (1), and an arc-shaped groove (38) is provided in the discharge port (37); An arc-shaped door (39) is slidably disposed in the arc-shaped groove (38); A fixing block (40) is arranged on a surface of the arc-shaped door (39) away from the axis of the tank body (1), and the fixing block (40) is fixedly connected to the arc-shaped door (39).

10. The enzymatic hydrolysis tank for heparin extraction according to claim 9, characterized in that: The discharging part comprises: A discharge pipe (41) is arranged on the tank body (1), the discharge pipe (41) is connected to the enzymolysis space (6), and the discharge pipe (41) is used to discharge the enzyme solution containing heparin from the tank body (1); a second control valve (42) is arranged on the discharge pipe (41) and is electrically connected to the control device (2) and is used to control the connection and closing of the discharge pipe (41) and the enzymolysis space (6).

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