An enzymatic hydrolysis tank for heparin extraction

Abstract

The present invention discloses an enzymolysis tank for heparin extraction, which relates to the technical field of enzymolysis tank equipment, including a tank body and a control device, wherein the tank body is provided with a feed portion electrically connected to the control device, and the enzymolysis tank for heparin extraction further comprises a partition fixedly arranged in the tank body, an enzymolysis mechanism arranged on the partition, a filtering mechanism arranged in the enzymolysis space, a discharge portion arranged on the tank body, and a discharge portion arranged on the tank body. This device is provided with an enzymolysis mechanism, thereby allowing the heparin raw material to fully contact with the enzyme solution, while also avoiding the heparin raw material from being entangled on the enzymolysis frame during the enzymolysis process, resulting in the heparin raw material entangled on the enzymolysis frame being unable to fully contact with the enzyme solution. At the same time, the reciprocating sliding cutter also facilitates chopping the heparin raw material, thereby further increasing the contact area between the heparin raw material and the enzyme solution, and further improving the heparin extraction effect of this device.

Description

Technical Field

[0001] The invention relates to the technical field of enzymolysis tank equipment, in particular to an enzymolysis tank for heparin extraction. Background Art

[0002] Heparin is a mucopolysaccharide of varying molecular lengths produced by mast cells in animal connective tissue. It possesses natural anticoagulant properties and has been the most common anticoagulant in clinical practice since its first clinical application as an anticoagulant in 1935. Currently, industrial heparin is primarily extracted from pig intestines. Due to the difficulty in quality control and the inherent high heterogeneity of pig intestinal heparin, researchers have been studying anticoagulant drugs to replace heparin and its oligosaccharides. However, due to its complex structure, cumbersome synthesis steps, and low product yield, research on the chemical production of heparin and its oligosaccharides has been fruitless. Heparin remains the primary antithrombotic and anticoagulant drug in clinical medicine.

[0003] Currently, heparin extraction mostly uses pig intestines as the raw material for heparin extraction, which is then combined with a corresponding enzyme solution to extract heparin. When extracting heparin, the pig intestines are easily entangled in the stirring components of the current heparin extraction equipment. This prevents the pig intestines from fully contacting the enzyme solution, thereby greatly reducing the extraction effect of the extraction equipment on heparin. Therefore, improvement is urgently needed. Summary of the Invention

[0004] In view of the shortcomings of the existing technology, the purpose of the present invention is to provide an enzymatic hydrolysis tank for heparin extraction, aiming to solve the above technical problems.

[0005] In order to achieve the above object, the present invention adopts the following technical solutions:

[0006] An enzymatic hydrolysis tank for heparin extraction, comprising a tank body and a control device, wherein the control device is detachably fixedly connected to the tank body, the tank body is fixedly provided with legs, and the tank body is provided with a feeding portion electrically connected to the control device. The enzymatic hydrolysis tank for heparin extraction further comprises:

[0007] A partition is fixedly disposed in the tank body, and the partition divides the interior of the tank body into a transmission space and an enzymolysis space;

[0008] an enzymatic hydrolysis mechanism, disposed on the partition and electrically connected to the control device, the enzymatic hydrolysis mechanism being used to assist in extracting heparin from the heparin raw material in the enzymatic hydrolysis space;

[0009] a filtering mechanism located in the enzymatic hydrolysis space, the filtering mechanism being disposed on the partition, the filtering mechanism being electrically connected to the control device, and the filtering mechanism being used to filter the heparin raw material after enzymatic hydrolysis;

[0010] A discharge portion, provided on the tank body, for discharging the heparin raw material processed by the filtering mechanism out of the tank body;

[0011] The discharge portion is provided on the tank body and is electrically connected to the control device. The discharge portion is used to discharge the enzyme solution containing heparin out of the tank body.

[0012] Preferably, the feeding part comprises:

[0013] A feed pipe is fixedly mounted on the tank body and is in communication with the enzymatic hydrolysis space;

[0014] a first material control valve, provided on the feed pipe and electrically connected to the control device, the first material control valve being used to control the connection and closing of the feed pipe and the enzymatic hydrolysis space;

[0015] The feeding hopper is fixedly arranged on the feeding pipe.

[0016] Preferably, the enzymatic hydrolysis mechanism comprises:

[0017] a power unit, disposed on the partition and electrically connected to the control device;

[0018] A bearing portion, disposed on the power portion, and configured to transmit power output by the power portion;

[0019] The enzymatic hydrolysis parts have two groups, and both groups of enzymatic hydrolysis parts are arranged on the supporting part. The enzymatic hydrolysis parts are used to stir the heparin raw material in the enzymatic hydrolysis space.

[0020] Preferably, the power unit includes:

[0021] an enzymatic hydrolysis motor, disposed on the partition and detachably fixedly connected to the partition, and electrically connected to the control device;

[0022] A rotating shaft is provided on the partition and is rotatably connected to the partition, and one end of the rotating shaft close to the enzymatic hydrolysis motor is fixedly connected to the output end of the enzymatic hydrolysis motor;

[0023] The connecting sleeve is arranged at one end of the rotating shaft away from the enzymatic hydrolysis motor and is fixedly connected to the rotating shaft.

[0024] Preferably, the bearing portion includes:

[0025] A bearing shaft is provided on the connecting sleeve and is detachably fixedly connected to the connecting sleeve;

[0026] There are two groups of longitudinal grooves, and both groups of longitudinal grooves are opened on the load-bearing shaft. The longitudinal grooves are provided with receiving grooves, and the receiving grooves are provided with engaging springs fixedly connected to the load-bearing shaft. The ends of the engaging springs close to the longitudinal grooves are fixedly provided with engaging balls.

[0027] The baffle is arranged at one end of the load-bearing shaft away from the connecting sleeve and is fixedly connected to the load-bearing shaft.

[0028] Preferably, the enzymatic hydrolysis unit comprises:

[0029] A fixing rod, disposed in the longitudinal groove and fixedly connected to the bearing shaft;

[0030] a rotating block rotatably disposed on the fixed rod;

[0031] A connecting rod, fixedly arranged on the rotating block;

[0032] The enzymolysis frame is arranged at the end of the connecting rod away from the fixed rod and is fixedly connected to the connecting rod. The enzymolysis frame is provided with a snap-fitting groove for cooperating with the snap-fitting ball.

[0033] A counterweight block is provided at one end of the enzymolysis frame away from the fixed rod and is fixedly connected to the enzymolysis frame, and the counterweight block is used to drive the enzymolysis frame to rotate out of the longitudinal groove;

[0034] A built-in rod is fixedly arranged in the enzymatic hydrolysis frame, a sliding block is slidably arranged on the built-in rod, a ball is rolled on the sliding block, and two symmetrical enzymatic hydrolysis springs are sleeved on the built-in rod, and the two ends of the enzymatic hydrolysis springs are respectively fixedly connected to the enzymatic hydrolysis frame and the sliding block.

[0035] Preferably, the filtering mechanism comprises:

[0036] There are multiple hydraulic push rods, and the multiple hydraulic push rods are evenly arranged on the partition plate, and the hydraulic push rods are electrically connected to the control device;

[0037] There are multiple pull rods, and the multiple pull rods are respectively arranged on adjacent hydraulic push rods;

[0038] an annular plate, fixedly arranged on the end of the pull rod away from the partition;

[0039] A filter plate is disposed on the annular plate and fixedly connected to the annular plate;

[0040] The extrusion part is located in the enzymatic hydrolysis space and is used for extruding the heparin raw material on the filter plate.

[0041] Preferably, the extrusion portion comprises:

[0042] There are multiple support plates, and the multiple support plates are evenly distributed on the inner surface of the tank body;

[0043] There are multiple extrusion springs, and the multiple extrusion springs are fixedly arranged on the surface of the partition close to the enzymatic hydrolysis space;

[0044] An extrusion plate is fixedly arranged at one end of the extrusion spring away from the partition plate, the partition plate is rotatably connected to the bearing shaft, and the extrusion plate is used to squeeze the heparin raw material on the filter plate;

[0045] There are multiple hanging plates, and the multiple hanging plates are fixedly arranged on the surface of the extrusion plate close to the partition plate. The hanging plates are used to cooperate with the supporting plates to suspend the extrusion plate.

[0046] Preferably, the discharge portion includes:

[0047] A discharge port is provided on the tank body, and an arc-shaped groove is provided in the discharge port;

[0048] An arc-shaped door is slidably arranged in the arc-shaped groove;

[0049] A fixing block is arranged on a surface of the arc door away from the axis of the tank body, and the fixing block is fixedly connected to the arc door.

[0050] Preferably, the discharging portion comprises:

[0051] a discharge pipe, provided on the tank body, the discharge pipe being in communication with the enzymatic hydrolysis space, and being used for discharging the enzyme solution containing heparin from the tank body;

[0052] The second material control valve is arranged on the discharge pipe and is electrically connected to the control device, and is used to control the connection and closing of the discharge pipe and the enzymatic hydrolysis space.

[0053] In summary, due to the adoption of the above technical solution, the beneficial effects of the present invention are:

[0054] 1. The device is provided with an enzymatic hydrolysis mechanism, thereby ensuring sufficient contact between the heparin raw material and the enzyme solution. At the same time, it also prevents the heparin raw material from being entangled on the enzymatic hydrolysis frame during the enzymatic hydrolysis process, resulting in the heparin raw material being unable to fully contact with the enzyme solution. At the same time, the reciprocating sliding cutter also facilitates chopping the heparin raw material, thereby further increasing the contact area between the heparin raw material and the enzyme solution, and further improving the heparin extraction effect of the device.

[0055] 2. The device is provided with a filtering mechanism, which enables the device to squeeze the heparin raw material after enzymatic hydrolysis, thereby squeezing out the enzyme solution containing heparin adsorbed by the heparin raw material, avoiding the waste of the enzyme solution containing heparin and improving the extraction effect of heparin to a certain extent. BRIEF DESCRIPTION OF THE DRAWINGS

[0056] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for use in describing the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0057] Figure 1 The figure shows a schematic diagram of the three-dimensional structure of an enzymatic hydrolysis tank for heparin extraction.

[0058] Figure 2 A front view of an enzymatic hydrolysis tank for heparin extraction is shown.

[0059] Figure 3 A side view of an enzymatic hydrolysis tank for heparin extraction is shown.

[0060] Figure 4 Shown Figure 3 Cross-sectional view of AA in the figure.

[0061] Figure 5 Shown Figure 4 A magnified schematic diagram of the local structure at point A in the middle.

[0062] Figure 6 A top view of an enzymatic hydrolysis tank for heparin extraction is shown.

[0063] Figure 7 A schematic diagram of the internal structure of an enzymatic hydrolysis tank for heparin extraction is shown.

[0064] Figure 8 An exploded view of a partial structure of an enzymatic hydrolysis tank for heparin extraction is shown.

[0065] Figure 9 Shown Figure 8 Exploded view of the middle part of the structure.

[0066] Figure 10 Shown Figure 9 A magnified schematic diagram of the local structure at point B in the middle.

[0067] Figure 11 An exploded view of the enzymatic hydrolysis section is shown.

[0068] Legend:

[0069] 1. Tank; 2. Control device; 3. Support legs; 4. Partition; 5. Transmission space; 6. Enzyme hydrolysis space; 7. Feed pipe; 8. First material control valve; 9. Feed hopper; 10. Enzyme hydrolysis motor; 11. Rotating shaft; 12. Connecting sleeve; 13. Bearing shaft; 14. Longitudinal groove; 15. Receiving groove; 16. Clamping spring; 17. Clamping ball; 18. Baffle; 19. Fixed rod; 20. Rotating block; 21. Connecting rod; 22. Enzyme hydrolysis Frame; 23. Engaging groove; 24. Counterweight; 25. Built-in rod; 26. Sliding cutter; 27. Ball; 28. Enzymatic hydrolysis spring; 29. ​​Hydraulic push rod; 30. Pull rod; 31. Ring plate; 32. Filter plate; 33. Support plate; 34. Extrusion spring; 35. Extrusion plate; 36. Hanging plate; 37. Discharge port; 38. Arc groove; 39. Arc door; 40. Fixed block; 41. Discharge pipe; 42. Second material control valve. DETAILED DESCRIPTION

[0070] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts shall fall within the scope of protection of the present invention.

[0071] In the description of the present invention, it should be understood that the terms "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention.

[0072] It should be noted that when a component is referred to as being "fixed to" another component, it may be directly on the other component or there may also be a central component. When a component is considered to be "connected to" another component, it may be directly connected to the other component or there may also be a central component. When a component is considered to be "set on" another component, it may be directly set on the other component or there may also be a central component. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are for illustrative purposes only.

[0073] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of the technical features being referred to. Thus, a feature identified as "first" or "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, "plurality" means two or more, unless otherwise specifically defined.

[0074] Reference Figures 1 to 11 , an embodiment of an enzymatic hydrolysis tank for heparin extraction of the present invention is further described.

[0075] A heparin extraction enzymolysis tank comprises a tank body 1 and a control device 2, wherein the control device 2 is detachably fixedly connected to the tank body 1, a support leg 3 is fixedly provided on the tank body 1, and a feeding part electrically connected to the control device 2 is provided on the tank body 1, wherein the feeding part comprises:

[0076] A feed pipe 7 is fixedly mounted on the tank body 1 and is in communication with the enzymatic hydrolysis space 6;

[0077] A first material control valve 8 is provided on the feed pipe 7 and is electrically connected to the control device 2. The first material control valve 8 is used to control the connection and closing of the feed pipe 7 and the enzymatic hydrolysis space 6;

[0078] The feed hopper 9 is fixedly arranged on the feed pipe 7 .

[0079] During operation, the first material control valve 8 is opened by the control device 2, and then the heparin raw material and the corresponding enzyme solution are sequentially fed into the enzymatic hydrolysis space 6 through the feed hopper 9 and the feed pipe 7, thereby facilitating the subsequent extraction of heparin from the heparin raw material.

[0080] The enzymatic hydrolysis tank for heparin extraction also includes:

[0081] A partition 4 is fixedly disposed in the tank body 1 and divides the interior of the tank body 1 into a transmission space 5 and an enzymolysis space 6;

[0082] an enzymatic hydrolysis mechanism, disposed on the partition 4 and electrically connected to the control device 2, the enzymatic hydrolysis mechanism being used to assist in extracting heparin from the heparin raw material in the enzymatic hydrolysis space 6;

[0083] Reference Figures 1 to 11 , the enzymatic hydrolysis mechanism comprises:

[0084] A power unit is provided on the partition 4 and is electrically connected to the control device 2;

[0085] The power unit includes:

[0086] The enzymatic hydrolysis motor 10 is provided on the partition 4 and is detachably fixedly connected to the partition 4. The enzymatic hydrolysis motor 10 is electrically connected to the control device 2;

[0087] A rotating shaft 11 is provided on the partition 4 and is rotatably connected to the partition 4. One end of the rotating shaft 11 close to the enzymatic hydrolysis motor 10 is fixedly connected to the output end of the enzymatic hydrolysis motor 10.

[0088] The connecting sleeve 12 is provided at one end of the rotating shaft 11 away from the enzymatic hydrolysis motor 10 and is fixedly connected to the rotating shaft 11 .

[0089] A bearing portion, disposed on the power portion, and configured to transmit power output by the power portion;

[0090] The bearing portion includes:

[0091] The bearing shaft 13 is provided on the connecting sleeve 12 and is detachably fixedly connected to the connecting sleeve 12;

[0092] There are two groups of longitudinal grooves 14, and both groups of longitudinal grooves 14 are formed on the load-bearing shaft 13. The longitudinal grooves 14 have a receiving groove 15 formed therein. The receiving groove 15 has a locking spring 16 fixedly connected to the load-bearing shaft 13. The end of the locking spring 16 near the longitudinal groove 14 is fixedly provided with a locking ball 17;

[0093] The baffle 18 is disposed at one end of the bearing shaft 13 away from the connecting sleeve 12 and is fixedly connected to the bearing shaft 13 .

[0094] There are two groups of enzymatic hydrolysis parts, and both groups of enzymatic hydrolysis parts are arranged on the supporting part, and the enzymatic hydrolysis parts are used to stir the heparin raw material in the enzymatic hydrolysis space 6;

[0095] The enzymatic hydrolysis unit comprises:

[0096] A fixing rod 19 is disposed in the longitudinal groove 14 and fixedly connected to the bearing shaft 13;

[0097] A rotating block 20 is rotatably mounted on the fixing rod 19;

[0098] A connecting rod 21 is fixedly mounted on the rotating block 20;

[0099] The enzymatic hydrolysis frame 22 is provided at the end of the connecting rod 21 away from the fixed rod 19 and is fixedly connected to the connecting rod 21. The enzymatic hydrolysis frame 22 is provided with a snap-fitting groove 23 for cooperating with the snap-fitting ball 17.

[0100] Reference Figures 1 to 11The control device 2 controls the enzymolysis motor 10 to start, so that the rotating shaft 11 fixedly connected to the output end of the enzymolysis motor 10 rotates, and then the connecting sleeve 12 fixedly connected to the rotating shaft 11 rotates, thereby driving the load-bearing shaft 13 connected to the connecting sleeve 12 to rotate, so that the fixed rod 19 provided on the load-bearing shaft 13 rotates around the axis of the load-bearing shaft 13, and then drives the rotating block 20 rotatably connected to the fixed rod 19 to rotate around the axis of the load-bearing shaft 13, so that the connecting rod 21 fixedly connected to the rotating block 20 drives the enzymolysis frame 22 to rotate around the axis of the load-bearing shaft 13, thereby stirring the heparin raw material in the enzyme solution in the enzymolysis space 6, thereby facilitating the extraction of heparin from the heparin raw material and improving the heparin extraction effect of the device.

[0101] A counterweight 24 is provided at one end of the enzymatic hydrolysis frame 22 away from the fixed rod 19 and is fixedly connected to the enzymatic hydrolysis frame 22. The counterweight 24 is used to drive the enzymatic hydrolysis frame 22 to rotate out of the longitudinal groove 14.

[0102] It should be noted that the provision of a counterweight 24 facilitates the process of rotating the enzymatic hydrolysis frame 22 out of the longitudinal groove 14. The specific process is as follows: the enzymatic hydrolysis motor 10 is started by the control device 2. When the speed of the enzymatic hydrolysis motor 10 reaches a certain speed, the counterweight 24 fixedly connected to the enzymatic hydrolysis frame 22 moves in a direction away from the axis of the load-bearing shaft 13 under the action of centrifugal force, thereby rotating the enzymatic hydrolysis frame 22 fixedly connected to the counterweight 24 out of the longitudinal groove 14.

[0103] The built-in rod 25 is fixedly arranged in the enzymatic hydrolysis frame 22. A sliding block 26 is slidingly arranged on the built-in rod 25, and a ball 27 is rollingly arranged on the sliding block 26. Two symmetrical enzymatic hydrolysis springs 28 are sleeved on the built-in rod 25, and the two ends of the enzymatic hydrolysis spring 28 are fixedly connected to the enzymatic hydrolysis frame 22 and the sliding block 26 respectively.

[0104] When the enzymatic hydrolysis frame 22 rotates around the axis of the load-bearing shaft 13, the speed of the enzymatic hydrolysis motor 10 is controlled by the control device 2, so that the centrifugal force exerted on the sliding block 26 in the enzymatic hydrolysis frame 22 changes, and the force applied by the sliding block 26 to the enzymatic hydrolysis springs 28 on both sides changes, so that the enzymatic hydrolysis springs 28 on both sides are deformed, so that the sliding block 26 can slide back and forth on the built-in rod 25 while rotating around the axis of the load-bearing shaft 13, thereby avoiding the heparin raw material from being entangled in the enzymatic hydrolysis frame 22 during the enzymatic hydrolysis process, resulting in the heparin raw material entangled in the enzymatic hydrolysis frame 22 being unable to fully contact the enzyme solution. At the same time, the reciprocating sliding block 26 also facilitates the chopping of the heparin raw material.

[0105] The device is provided with an enzymatic hydrolysis mechanism, thereby ensuring sufficient contact between the heparin raw material and the enzyme solution. At the same time, it also prevents the heparin raw material from being entangled on the enzymatic hydrolysis frame 22 during the enzymatic hydrolysis process, resulting in the heparin raw material being unable to fully contact with the enzyme solution when entangled on the enzymatic hydrolysis frame 22. At the same time, the reciprocating sliding cutting block 26 also facilitates chopping the heparin raw material, thereby further increasing the contact area between the heparin raw material and the enzyme solution, and further improving the heparin extraction effect of the device.

[0106] Reference Figures 1 to 11 , a filtering mechanism is located in the enzymatic hydrolysis space 6, the filtering mechanism is arranged on the partition 4, the filtering mechanism is electrically connected to the control device 2, and the filtering mechanism is used to filter the heparin raw material after enzymatic hydrolysis;

[0107] The filtering mechanism comprises:

[0108] There are multiple hydraulic push rods 29, and the multiple hydraulic push rods 29 are evenly arranged on the partition 4, and the hydraulic push rods 29 are electrically connected to the control device 2;

[0109] There are multiple pull rods 30, and the multiple pull rods 30 are respectively arranged on adjacent hydraulic push rods 29;

[0110] The annular plate 31 is fixedly arranged on the end of the pull rod 30 away from the partition 4;

[0111] The filter plate 32 is disposed on the annular plate 31 and is fixedly connected to the annular plate 31;

[0112] An extrusion unit, located in the enzymatic hydrolysis space 6, for extruding the heparin raw material on the filter plate 32;

[0113] The extrusion portion includes:

[0114] There are multiple support plates 33, and the multiple support plates 33 are evenly distributed on the inner surface of the tank body 1;

[0115] There are multiple extrusion springs 34, and the multiple extrusion springs 34 are fixedly arranged on the surface of the partition 4 close to the enzymatic hydrolysis space 6;

[0116] The squeezing plate 35 is fixedly disposed on the end of the squeezing spring 34 away from the partition 4. The partition 4 is rotatably connected to the bearing shaft 13. The squeezing plate 35 is used to squeeze the heparin raw material on the filter plate 32.

[0117] There are multiple hanging plates 36 , and the multiple hanging plates 36 are fixedly arranged on the surface of the extrusion plate 35 close to the partition plate 4 . The hanging plates 36 are used to cooperate with the support plate 33 to suspend the extrusion plate 35 .

[0118] Reference Figures 1 to 11After the heparin in the heparin raw material is extracted, the enzymatic hydrolysis motor 10 is turned off by the control device 2 and the hydraulic push rod 29 is activated simultaneously, causing the hydraulic push rod 29 to retract, thereby causing the pull rod 30 fixedly connected to the hydraulic push rod 29 to move toward the partition 4. In turn, the annular plate 31 fixedly connected to the pull rod 30 drives the filter plate 32 to move toward the partition 4. During the process of the filter plate 32 moving toward the partition 4, the heparin raw material in the enzyme solution is also filtered out and the filtered heparin raw material is driven toward the partition 4 until the filter plate 32 contacts the extrusion plate 35 and pushes the extrusion plate 35 toward the partition 4. As a result, the extrusion spring 34 fixedly connected to the extrusion plate 35 is compressed, causing the extrusion spring 34 to apply a certain force to the extrusion plate 35, thereby causing the extrusion plate 35 to apply a certain force to the filter plate 32, thereby squeezing the heparin raw material on the filter plate 32, and then squeezing the enzyme solution containing heparin adsorbed by the heparin raw material out and flowing through the filter plate 32 into the enzyme solution containing heparin below the filter plate 32.

[0119] The device is provided with a filtering mechanism, so that the device can squeeze the heparin raw material after enzymatic hydrolysis, thereby squeezing out the enzyme solution containing heparin adsorbed by the heparin raw material, avoiding the waste of the enzyme solution containing heparin and improving the extraction effect of heparin to a certain extent.

[0120] Reference Figures 1 to 11 , a discharge portion is provided on the tank body 1 and is used to discharge the heparin raw material processed by the filtering mechanism out of the tank body 1;

[0121] The discharge part includes:

[0122] A discharge port 37 is provided on the tank body 1 and an arc-shaped groove 38 is provided in the discharge port 37;

[0123] an arc-shaped door 39 slidably disposed in the arc-shaped slot 38;

[0124] The fixing block 40 is provided on the surface of the arc door 39 away from the axis of the tank body 1 , and the fixing block 40 is fixedly connected to the arc door 39 .

[0125] After the enzyme solution containing heparin adsorbed by the heparin raw material is completely squeezed out, the staff pushes the arc door 39 to slide in the arc groove 38 through the fixed block 40, so that subsequent staff can discharge the squeezed heparin raw material into the tank body 1 through the discharge port 37.

[0126] a discharge portion, disposed on the tank body 1 and electrically connected to the control device 2, and configured to discharge the enzyme solution containing heparin from the tank body 1;

[0127] The discharging part comprises:

[0128] A discharge pipe 41 is provided on the tank body 1 and is in communication with the enzymatic hydrolysis space 6. The discharge pipe 41 is used to discharge the enzyme solution containing heparin from the tank body 1.

[0129] The second material control valve 42 is provided on the discharge pipe 41 and is electrically connected to the control device 2 , and is used to control the connection and closing of the discharge pipe 41 and the enzymatic hydrolysis space 6 .

[0130] After the squeezed heparin raw material is discharged from the tank body 1 , the second material control valve 42 is controlled to open by the control device 2 , thereby discharging the enzyme solution containing heparin in the enzymatic hydrolysis space 6 from the tank body 1 .

[0131] Working principle: Refer to Figures 1 to 11 During operation, the first material control valve 8 is controlled to be opened by the control device 2, and then the heparin raw material and the corresponding enzyme solution are sequentially fed into the enzymolysis space 6 through the feed hopper 9 and the feed pipe 7, and then the enzymolysis motor 10 is controlled to start by the control device 2, so that the rotating shaft 11 fixedly connected to the output end of the enzymolysis motor 10 rotates, and then the connecting sleeve 12 fixedly connected to the rotating shaft 11 rotates, thereby driving the bearing shaft 13 connected to the connecting sleeve 12 to rotate, so that the fixed rod 19 provided on the bearing shaft 13 rotates around the axis of the bearing shaft 13, and then drives the rotating block 20 rotatably connected to the fixed rod 19 to rotate around the axis of the bearing shaft 13, so that the connecting rod 21 fixedly connected to the rotating block 20 drives the enzymolysis frame 22 to rotate around the axis of the bearing shaft 13, thereby stirring the heparin raw material in the enzyme solution in the enzymolysis space 6, thereby facilitating the extraction of heparin from the heparin raw material and improving the heparin extraction effect of the device;

[0132] When the enzymolysis frame 22 rotates around the axis of the supporting shaft 13, the speed of the enzymolysis motor 10 is controlled by the control device 2, so that the centrifugal force exerted on the sliding block 26 in the enzymolysis frame 22 changes, and the force exerted by the sliding block 26 on the enzymolysis springs 28 on both sides changes, so that the enzymolysis springs 28 on both sides are deformed, so that the sliding block 26 can slide back and forth on the built-in rod 25 while rotating around the axis of the supporting shaft 13, thereby avoiding the heparin raw material from being entangled on the enzymolysis frame 22 during the enzymolysis process, resulting in the heparin raw material entangled on the enzymolysis frame 22 being unable to fully contact with the enzyme solution. At the same time, the reciprocating sliding block 26 also facilitates the chopping of the heparin raw material, so that the heparin raw material can fully contact with the enzyme solution, greatly improving the heparin extraction effect of the present device;

[0133] After the heparin in the heparin raw material is extracted, the enzymatic hydrolysis motor 10 is turned off by the control device 2 and the hydraulic push rod 29 is started at the same time, so that the hydraulic push rod 29 contracts, thereby causing the pull rod 30 fixedly connected to the hydraulic push rod 29 to move toward the partition 4, and then the annular plate 31 fixedly connected to the pull rod 30 drives the filter plate 32 to move toward the partition 4. In the process of the filter plate 32 moving toward the partition 4, the heparin raw material in the enzyme solution is also filtered out and the filtered heparin raw material is driven to move toward the partition 4 until the filter plate 32 contacts the extrusion plate 35 and pushes the extrusion plate 35 to move toward the partition 4, thereby making the filter plate 31 and the extrusion plate 31 contact each other. The fixedly connected extrusion spring 34 is compressed, causing the extrusion spring 34 to exert a certain force on the extrusion plate 35, thereby causing the extrusion plate 35 to exert a certain force on the filter plate 32, thereby squeezing the heparin raw material on the filter plate 32, and then squeezing out the heparin-containing enzyme solution adsorbed by the heparin raw material and flowing through the filter plate 32 into the heparin-containing enzyme solution below the filter plate 32. After the heparin-containing enzyme solution adsorbed by the heparin raw material is completely squeezed out, the staff pushes the arc door 39 to slide in the arc groove 38 through the fixed block 40, so that subsequent staff can discharge the squeezed heparin raw material into the tank body 1 through the discharge port 37.

[0134] After the squeezed heparin raw material is discharged from the tank body 1 , the second material control valve 42 is controlled to open by the control device 2 , thereby discharging the enzyme solution containing heparin in the enzymatic hydrolysis space 6 from the tank body 1 .

[0135] It should be noted that, in the process of the filter plate 32 moving toward the partition 4, the filter plate 32 pushes the enzymolysis frame 22 to rotate around the fixed rod 19 until the enzymolysis frame 22 is rotated into the longitudinal groove 14. In the process of the enzymolysis frame 22 rotating into the longitudinal groove 14, the surface of the enzymolysis frame 22 close to the snap ball 17 applies pressure to the snap ball 17, so that the snap ball 17 squeezes the snap spring 16 to slide into the receiving groove 15. After the enzymolysis frame 22 completely slides into the longitudinal groove 14, the compressed snap spring 16 releases its elastic potential energy to snap the snap ball 17. 7 is pushed in the direction of the engaging groove 23 until the engaging ball 17 slides into the engaging groove 23, thereby fixing the enzymolysis frame 22 in the longitudinal groove 14. The process of rotating the enzymolysis frame 22 out of the longitudinal groove 14 is as follows: the enzymolysis motor 10 is controlled to start by the control device 2. When the speed of the enzymolysis motor 10 reaches a certain speed, the counterweight block 24 fixedly connected to the enzymolysis frame 22 moves in the direction away from the axis of the load-bearing shaft 13 under the action of centrifugal force, thereby rotating the enzymolysis frame 22 fixedly connected to the counterweight block 24 out of the longitudinal groove 14.

[0136] The above description of the embodiments is intended to enable one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention is not limited to the embodiments shown herein but is intended to conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. An enzymatic hydrolysis tank for heparin extraction, comprising a tank body (1) and a control device (2), wherein the control device (2) is detachably fixedly connected to the tank body (1), and a support leg (3) is fixedly provided on the tank body (1), characterized in that: The tank body (1) is provided with a feed portion electrically connected to the control device (2), and the enzymatic hydrolysis tank for heparin extraction further comprises: A partition (4) is fixedly arranged in the tank body (1), and the partition (4) divides the interior of the tank body (1) into a transmission space (5) and an enzymolysis space (6); an enzymatic hydrolysis mechanism, disposed on the partition (4) and electrically connected to the control device (2), the enzymatic hydrolysis mechanism being used to assist in extracting heparin from the heparin raw material in the enzymatic hydrolysis space (6); A filtering mechanism is located in the enzymatic hydrolysis space (6), the filtering mechanism is arranged on the partition (4), the filtering mechanism is electrically connected to the control device (2), and the filtering mechanism is used to filter the heparin raw material after enzymatic hydrolysis; A discharge portion, provided on the tank body (1), for discharging the heparin raw material processed by the filtering mechanism out of the tank body (1); a discharge portion, disposed on the tank body (1) and electrically connected to the control device (2), the discharge portion being used to discharge the enzyme solution containing heparin out of the tank body (1); The enzymatic hydrolysis mechanism comprises: A power unit, disposed on the partition (4) and electrically connected to the control device (2); A bearing portion, disposed on the power portion, and configured to transmit power output by the power portion; The enzymatic hydrolysis part has two groups, and both groups of enzymatic hydrolysis parts are arranged on the supporting part, and the enzymatic hydrolysis parts are used to stir the heparin raw material in the enzymatic hydrolysis space (6); The enzymatic hydrolysis unit comprises: A fixing rod (19) is arranged in the longitudinal groove (14), the longitudinal groove (14) is opened on the bearing shaft (13), and the fixing rod (19) is fixedly connected to the bearing shaft (13); A rotating block (20) is rotatably mounted on the fixed rod (19); A connecting rod (21) is fixedly mounted on the rotating block (20); An enzymatic hydrolysis frame (22) is provided at one end of the connecting rod (21) away from the fixed rod (19) and is fixedly connected to the connecting rod (21). The enzymatic hydrolysis frame (22) is provided with a snap-fitting groove (23) for cooperating with the snap-fitting ball (17); A counterweight (24) is provided at one end of the enzymolysis frame (22) away from the fixed rod (19) and is fixedly connected to the enzymolysis frame (22). The counterweight (24) is used to drive the enzymolysis frame (22) to rotate out of the longitudinal groove (14); A built-in rod (25) is fixedly arranged in the enzymolysis frame (22), a sliding block (26) is slidably arranged on the built-in rod (25), a ball (27) is rolled on the sliding block (26), and two symmetrical enzymolysis springs (28) are sleeved on the built-in rod (25), and the two ends of the enzymolysis spring (28) are fixedly connected to the enzymolysis frame (22) and the sliding block (26), respectively.

2. The enzymatic hydrolysis tank for heparin extraction according to claim 1, characterized in that: The feeding part comprises: A feed pipe (7) is fixedly mounted on the tank body (1), and the feed pipe (7) is connected to the enzymatic hydrolysis space (6); a first material control valve (8), which is arranged on the feed pipe (7) and is electrically connected to the control device (2), and is used to control the connection and closing of the feed pipe (7) and the enzymatic hydrolysis space (6); The feed hopper (9) is fixedly arranged on the feed pipe (7).

3. The enzymatic hydrolysis tank for heparin extraction according to claim 2, characterized in that: The power unit includes: An enzymatic hydrolysis motor (10) is disposed on the partition (4) and is detachably fixedly connected to the partition (4), and the enzymatic hydrolysis motor (10) is electrically connected to the control device (2); A rotating shaft (11) is provided on the partition (4) and is rotatably connected to the partition (4); an end of the rotating shaft (11) close to the enzymatic hydrolysis motor (10) is fixedly connected to the output end of the enzymatic hydrolysis motor (10); The connecting sleeve (12) is arranged at one end of the rotating shaft (11) away from the enzymatic hydrolysis motor (10) and is fixedly connected to the rotating shaft (11).

4. The enzymatic hydrolysis tank for heparin extraction according to claim 3, characterized in that: The bearing portion includes: A bearing shaft (13) is provided on the connecting sleeve (12) and is detachably fixedly connected to the connecting sleeve (12); There are two groups of longitudinal grooves (14), and both groups of longitudinal grooves (14) are opened on the load-bearing shaft (13). A receiving groove (15) is opened in the longitudinal groove (14), and a locking spring (16) fixedly connected to the load-bearing shaft (13) is provided in the receiving groove (15). A locking ball (17) is fixedly provided at the end of the locking spring (16) close to the longitudinal groove (14); The baffle (18) is arranged at one end of the load-bearing shaft (13) away from the connecting sleeve (12) and is fixedly connected to the load-bearing shaft (13).

5. The enzymatic hydrolysis tank for heparin extraction according to claim 4, characterized in that: The filtering mechanism comprises: There are multiple hydraulic push rods (29), and the multiple hydraulic push rods (29) are evenly arranged on the partition (4), and the hydraulic push rods (29) are electrically connected to the control device (2); There are multiple pull rods (30), and the multiple pull rods (30) are respectively arranged on adjacent hydraulic push rods (29); An annular plate (31) is fixedly arranged on an end of the pull rod (30) away from the partition (4); A filter plate (32) is disposed on the annular plate (31) and fixedly connected to the annular plate (31); The extrusion part is located in the enzymatic hydrolysis space (6) and is used to extrude the heparin raw material on the filter plate (32).

6. The enzymatic hydrolysis tank for heparin extraction according to claim 5, characterized in that: The extrusion portion includes: There are multiple support plates (33), and the multiple support plates (33) are evenly distributed on the inner surface of the tank body (1); There are multiple extrusion springs (34), and the multiple extrusion springs (34) are fixedly arranged on the surface of the partition (4) close to the enzymatic hydrolysis space (6); An extrusion plate (35) is fixedly arranged on one end of the extrusion spring (34) away from the partition (4), the partition (4) is rotatably connected to the bearing shaft (13), and the extrusion plate (35) is used to extrude the heparin raw material on the filter plate (32); There are multiple hanging plates (36), and the multiple hanging plates (36) are fixedly arranged on the surface of the extrusion plate (35) close to the partition plate (4). The hanging plates (36) are used to cooperate with the support plate (33) to suspend the extrusion plate (35).

7. The enzymatic hydrolysis tank for heparin extraction according to claim 6, characterized in that: The discharge part includes: A discharge port (37) is provided on the tank body (1), and an arc-shaped groove (38) is provided in the discharge port (37); An arc-shaped door (39) is slidably disposed in the arc-shaped groove (38); A fixing block (40) is provided on a surface of the arc door (39) away from the axis of the tank body (1), and the fixing block (40) is fixedly connected to the arc door (39).

8. The enzymatic hydrolysis tank for heparin extraction according to claim 7, characterized in that: The discharging part comprises: a discharge pipe (41) disposed on the tank body (1), the discharge pipe (41) being in communication with the enzymatic hydrolysis space (6), and the discharge pipe (41) being used to discharge the enzyme solution containing heparin from the tank body (1); The second material control valve (42) is provided on the discharge pipe (41) and is electrically connected to the control device (2) for controlling the connection and closing of the discharge pipe (41) and the enzymatic hydrolysis space (6).

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