Chinese herbal medicine female care solution formula and preparation method thereof

Abstract

The invention provides a Chinese herbal medicine female care solution product and a preparation method thereof, the care solution is prepared from the following raw materials by weight: 10-15 parts of rose hydrolat, 3-5 parts of mint hydrolat, 30-45 parts of a Chinese herbal medicine extract, 3-5 parts of kapur, 1-5 parts of chelated platinum ions, and 6-12 parts of a composite bacteriostatic agent; the preparation method comprises the following steps: adding the rose hydrolat and the mint hydrolat into the Chinese herbal medicine extract to obtain a stock solution, diluting the stock solution, adding the kapur, fully stirring, filtering to obtain a filtrate, adding the chelated platinum ions and the composite bacteriostatic agent, and uniformly stirring to obtain the product.

Description

A Chinese herbal medicine women's care solution formula and preparation method Technical Field

[0001] The present invention relates to the field of women's hygiene care, and in particular to a formula of a Chinese herbal medicine women's care liquid and a preparation method thereof. Background Art

[0002] Modern women face increased social responsibilities and life pressures, forcing them to navigate a fast-paced lifestyle. They spend the majority of their time in the office, commuting, and on business trips, and even more time in public places, increasing their risk of infection. According to relevant data, approximately 85% of adult women worldwide suffer from varying degrees of gynecological inflammation, 46% of whom experience recurrent episodes. The target consumer demographic is trending towards younger ages, with 53.9% of students experiencing symptoms of vaginitis, with bacterial vaginosis being the most common (35.9%), followed by candidiasis (23.6%). Therefore, daily antibacterial and hygiene practices are crucial for reducing the incidence of gynecological inflammation.

[0003] Feminine care lotion, also known as vaginal cleansing lotion or feminine antibacterial lotion, is used by women to cleanse, eliminate bad odors, treat gynecological inflammation, and kill pathogenic microorganisms and disinfect the genitals. Men can also use it for genital disinfection. Feminine care lotions available in the Chinese market are categorized into health-conscious products using natural lactic acid and herbal extracts as their primary ingredients, and over-the-counter products using traditional Chinese medicine as their primary ingredient.

[0004] Existing feminine care solutions are typically feminine washes or douches, including cleansing, care, and maintenance, antibacterial, and therapeutic washes. Cleansing, care, and maintenance washes are primarily used for daily vaginal cleansing due to normal secretions and discharge, and are often referred to as care or feminine care washes. Antibacterial washes, as the name suggests, are primarily used for antibacterial purposes in the female genitals. Therapeutic washes, such as Jie'eryin Wash, Huangkui Wash, and Jiaoyan Jieyin Wash, are used when women are suffering from various vaginal infections.

[0005] Chinese patent document CN200610032397.8 discloses a herbal care solution for women's menstrual period and daily use that can shrink the vagina, kill bacteria and relieve itching. The solution is prepared from the following drugs in the following weight ratios: 10-30g each of Radix Sophorae Flavescentis, Radix Eupatorii, Fructus Cnidium, Fructus Kochiae, Fructus Dictamni, and Flos Lonicerae; 5-20g each of Radix Sophorae Flavescentis, Radix Stemonae, Radix Scutellariae, Bletilla striata, Fructus Corni, Rhizoma Pomegranatee, Fructus Myricae, Radix Aucklandiae, Fructus Loquatii, Gallnut, Cortex Moutan, and Radix Angelicae Dahuricae; 5-20g each of Radix Asarum, Fructus Sichuane, and Fructus Chuanxiong. , 5-10 grams each of garlic, soak the above Chinese herbal medicines in alcohol water, and use reflux extraction to obtain the upper clear liquid; then according to 60-80 grams of Chinese herbal medicine extract, 3-5 grams of fungicide, 1-2 grams of moisturizer, 1-2 grams of natural anti-allergic agent, 0.5-1 gram of chelating agent (alum), 0.3-0.5 grams of essence, mix and prepare, and separate by chelation and sedimentation to obtain pure clear liquid; but the antibacterial effect of this care solution is not good in actual use, and its applicability is not wide. Summary of the Invention

[0006] In order to solve the deficiencies of the existing technology, the purpose of the present invention is to provide a Chinese herbal medicine women's care liquid formula and a preparation method thereof, which has excellent bactericidal effect, can effectively clean the female vulva, kill bacteria and relieve itching, remove odor, prevent vulvar inflammation, and has no side effects on the human body.

[0007] In order to achieve the above object, the present invention adopts the following technical solutions:

[0008] A formula for a Chinese herbal women's care solution, comprising the following raw materials, in parts by weight: 10-15 parts of rose hydrosol, 3-5 parts of peppermint hydrosol, 30-45 parts of a Chinese herbal extract, 3-5 parts of borneol, 1-5 parts of chelated platinum ions, and 6-12 parts of a composite antibacterial agent;

[0009] The preparation method of the composite antibacterial agent comprises the following steps:

[0010] (1) Dispersing nano-silica in an ethanol aqueous solution, then adding ammonia water and 3-mercaptopropyltrimethoxysilane, stirring to react, centrifuging, washing, and drying the product to obtain mercapto-silica;

[0011] (2) Dodecafluoroheptyl methacrylate and vinylguanamine are added to N,N-dimethylformamide and stirred to obtain a mixed solution. Then, thiolated silica is dispersed in the mixed solution, ultrasonically dispersed, a photoinitiator is added, and the mixture is reacted under ultraviolet light. The product is centrifuged, washed with isopropyl alcohol, and dried to obtain a composite antibacterial agent.

[0012] Preferably, in step (1), the concentration of the ethanol aqueous solution is 50-75 wt%, and the concentration of the ammonia water is 15-25 wt%.

[0013] Preferably, in step (1), the weight ratio of nano-silica, ethanol aqueous solution, ammonia water, and 3-mercaptopropyltrimethoxysilane is 10:50~70:8~17:3~6.

[0014] Preferably, in step (1), the reaction conditions are 20-35° C. in a N 2 atmosphere for 5-8 h.

[0015] Preferably, in step (2), the weight ratio of dodecafluoroheptyl methacrylate, vinylguanamine, N,N-dimethylformamide, and mercaptosilane is 2-5:4-7:30-50:10.

[0016] Preferably, in step (2), the photoinitiator is one or more of benzoin dimethyl ether, benzoin ethyl ether, and benzoin butyl ether.

[0017] Preferably, in step (2), the ultrasonic dispersion time is 5-15 min, the main ultraviolet wavelength is 360-365 nm, and the ultraviolet light intensity is 50-100 mW / cm 2 , irradiation time is 30~60min, and reaction temperature is 30~40℃.

[0018] Preferably, the preparation method of the Chinese herbal medicine extract comprises the following steps: weighing 1-2 parts of safflower, 8-12 parts of peach kernel, 8-12 parts of forsythia, 8-13 parts of chrysanthemum, 7-13 parts of perilla, 18-25 parts of platycodon, 8-11 parts of star anise, 9-14 parts of costus root, 7-12 parts of podocarp, 10-12 parts of atractylodes, 10-12 parts of white atractylodes, 9-13 parts of green peel, 10-12 parts of cloves, 4-6 parts of zanthoxylum bungeanum, and 13-16 parts of tea leaves, adding the mixture to a reaction vessel, then adding 500 parts of deionized water, and distilling and extracting at 94-97°C for 1.5-3h to obtain the Chinese herbal medicine extract.

[0019] The present invention also claims protection for a preparation method of the Chinese herbal women's care solution formula, comprising the following steps: adding rose hydrosol and mint hydrosol to a Chinese herbal medicine extract to obtain a stock solution, diluting the stock solution and adding borneol, stirring thoroughly and filtering to obtain a filtrate, adding chelated platinum ions and a composite antibacterial agent, and stirring evenly to obtain the Chinese herbal women's care solution.

[0020] Preferably, the stock solution is diluted 10 to 20 times.

[0021] Compared with the prior art, the present invention has the following beneficial effects:

[0022] Safflower: It promotes blood circulation and menstruation, dissipates blood stasis and relieves pain. It helps to treat amenorrhea, dysmenorrhea, lochia retention, chest pain, heart pain due to blood stasis, chest and flank pain, traumatic injuries, and sores and swelling.

[0023] Peach kernel: It has the effects of promoting blood circulation and removing blood stasis, moistening the intestines and promoting bowel movements, and relieving cough and asthma. It is used to treat amenorrhea, dysmenorrhea, abdominal masses, lung and intestinal abscesses, traumatic injuries, dry intestines and constipation, and cough and asthma.

[0024] Forsythia: Clears away heat, detoxifies, disperses stagnation, and reduces swelling. Treats febrile diseases, erysipelas, rashes, carbuncles, ulcers, scrofula, and stranguria.

[0025] Chrysanthemum: dispels wind, clears heat, improves eyesight, and detoxifies. Treats headaches, dizziness, red eyes, chest heat, furuncles, and swelling.

[0026] Perilla: The leaves are diaphoretic, antitussive, aromatic stomachic and diuretic, with analgesic, sedative and detoxifying effects, and can treat colds; the stems have the function of calming qi and stabilizing pregnancy; the seeds can relieve cough, eliminate phlegm, relieve asthma, and disperse mental dullness.

[0027] Platycodon grandiflorum: clears the lungs, relieves sore throat, eliminates phlegm, and discharges pus. It is used for cough with excessive phlegm, chest tightness, sore throat, hoarseness, lung abscess with vomiting pus, and sores with pus that do not break.

[0028] Star anise: It is warm in nature and pungent in flavor. It has the effects of warming yang, dispelling cold, regulating qi and relieving pain. It is used to treat cold vomiting, abdominal pain caused by cold hernia, low back pain caused by kidney deficiency, and dry and wet athlete's foot.

[0029] Costus root: Promotes qi circulation and relieves pain, strengthens the spleen and aids digestion. Used for chest and abdominal distension and pain, heaviness after diarrhea, indigestion, and loss of appetite.

[0030] Patchouli: Invigorates Qi, harmonizes the stomach, dispels filth and dampness. Treats colds, summer heat, fever, headaches, chest and abdominal distension, vomiting and diarrhea, malaria, dysentery, and bad breath.

[0031] Cangshu: Strengthens the spleen, dries dampness, relieves depression, and dispels filth. Treats dampness that blocks the spleen, fatigue and sleepiness, abdominal distension, loss of appetite, vomiting, diarrhea, dysentery, malaria, phlegm and fluid retention, edema, seasonal colds, wind-cold-dampness arthritis, foot paralysis, and night blindness.

[0032] Atractylodes macrocephala: tonifies the spleen, benefits the stomach, eliminates dampness, harmonizes the middle, and stabilizes the fetus. Treats spleen and stomach qi deficiency, loss of appetite, fatigue and shortness of breath, bloating, diarrhea, phlegm and fluid retention, edema, jaundice, dampness and arthritis, dysuria, dizziness, spontaneous sweating, and fetal restlessness.

[0033] Qingpi: Soothes the liver and dispels qi, eliminates stagnation and resolves stagnation. Used for chest and flank pain, hernia, breast nodules, mastitis, and abdominal pain caused by food stagnation.

[0034] Clove: warms the middle, warms the kidneys, and reduces adverse reactions. It is used to treat hiccups, vomiting, nausea, diarrhea, cold pain in the heart and abdomen, abdominal distension, hernia, and ringworm.

[0035] Zanthoxylum bungeanum: warms the middle and dispels cold, removes dampness, relieves pain, kills insects, and detoxifies fishy smell. It is used to treat indigestion, cold pain in the heart and abdomen, vomiting, belching, cough and shortness of breath, wind-cold-dampness arthritis, diarrhea, dysentery, hernia pain, toothache, ascariasis, pinworm disease, vaginal itching, and scabies.

[0036] Tea: Clears the head and eyes, relieves thirst, resolves phlegm, helps digestion, promotes urination, and detoxifies. Treats headaches, blurred vision, excessive sleep, restlessness and thirst, food stagnation and phlegm, malaria, and dysentery.

[0037] Camphor: used for coma caused by closed syndrome, red and swollen eyes, sore throat and mouth ulcers, swollen and painful sores, ulcers that do not heal, angina pectoris, etc.

[0038] 1) The present invention discloses a Chinese herbal medicine women's care solution, which is prepared from plant ingredients with anti-inflammatory, antioxidant, anti-allergic, infection-reducing, and immune-enhancing effects, composite antibacterial ingredients, and chelated platinum ions that catalyze and enhance the performance of the herbal medicine. The synthesized care solution can effectively cleanse the female vulva, nourish, remove odor, relieve itching, prevent allergies, and inhibit bacteria. At the same time, it can also effectively moisturize and maintain the skin of the female private parts. It can be used by spraying, without the need for traditional water washing or irrigation methods, and is convenient and quick.

[0039] 2) The present invention provides a composite antibacterial agent, which first uses 3-mercaptopropyltrimethoxysilane to organically modify nano-silica to obtain mercapto-silica, which can effectively improve the dispersibility of nano-silica and prevent the aggregation and sedimentation of nano-silica in the care solution; then, under ultraviolet light irradiation, dodecafluoroheptyl methacrylate and vinylguanamine are grafted onto the mercapto-silica through a mercapto-ene reaction to obtain a composite antibacterial agent; vinylguanamine is positively charged in water and can be adsorbed on the surface of negatively charged microorganisms, penetrate into the microorganisms, disrupt the normal metabolic process of the microorganisms, and inactivate bacteria and viruses. It has almost no toxicity to normal eukaryotic cells, is safe and non-toxic to the human body, and will not cause bacteria to develop drug resistance, so it can bring excellent antibacterial activity; dodecafluoroheptyl methacrylate has excellent hydrophobic properties, can prevent the initial adhesion of bacteria and proteins, inhibit the formation of biofilms, and thus synergistically with vinylguanamine to inhibit and kill bacteria. Implementation Method

[0040] In order to make the purpose, technical solutions and advantages of the present invention clearer, the present invention is further described in detail below in conjunction with the embodiments. Of course, the specific embodiments described here are only used to explain the present invention and are not used to limit the present invention.

[0041] Unless otherwise specified, the chemical reagents and materials in the present invention are purchased from commercial sources or synthesized from commercially purchased raw materials.

[0042] The particle size of nano-silica is 75~120nm;

[0043] Rose hydrosol and mint hydrosol were purchased from Guangzhou Zhonghe International Biotechnology Co., Ltd.

[0044] Chelated platinum ions were purchased from Asia-Pacific Technology Group.

[0045] The present invention will be further described below with reference to specific examples. Example

[0046] A method for preparing a Chinese herbal medicine women's care solution comprises the following steps:

[0047] (1) Disperse 10 g of nano-silica in 70 g of 75 wt% ethanol aqueous solution, then add 17 g of 20 wt% ammonia water and 6 g of 3-mercaptopropyltrimethoxysilane, and stir the mixture at 35 °C in a N2 atmosphere for 8 h. The product is centrifuged, washed, and dried to obtain mercapto-silica.

[0048] (2) Add 5 g of dodecafluoroheptyl methacrylate and 7 g of vinylguanamine to 50 g of N,N-dimethylformamide and stir to obtain a mixed solution. Then disperse 10 g of mercaptosilane into the mixed solution and ultrasonically disperse for 15 min. Add 0.2 g of benzoin ethyl ether and ultrasonically disperse at a main wavelength of 365 nm and an intensity of 100 mW / cm 2 The mixture was reacted at 40°C for 60 min under ultraviolet light, and the product was centrifuged, washed with isopropanol, and dried to obtain a composite antibacterial agent;

[0049] (3) Weigh 2 g of safflower, 10 g of peach kernel, 10 g of forsythia, 11 g of chrysanthemum, 10 g of perilla, 22 g of platycodon, 9 g of star anise, 12 g of costus root, 8 g of agave root, 11 g of atractylodes, 11 g of white atractylodes, 11 g of green peel, 11 g of clove, 5 g of Zanthoxylum bungeanum, and 15 g of tea leaves, add them to a reaction vessel, then add 500 g of deionized water, and distill and extract at 96 ° C for 2.5 h to obtain the Chinese herbal medicine extract;

[0050] (4) Add 15g of rose hydrosol and 5g of mint hydrosol to 45g of Chinese herbal medicine extract to obtain the stock solution. Dilute the stock solution 20 times and add 5g of borneol. Stir thoroughly and filter to obtain the filtrate. Add 5g of chelated platinum ions and 12g of compound antibacterial agent and stir evenly to obtain the Chinese herbal medicine women's care solution. Example

[0051] A method for preparing a Chinese herbal medicine women's care solution comprises the following steps:

[0052] (1) Disperse 10 g of nano-silica in 60 g of 75 wt% ethanol aqueous solution, then add 12 g of 20 wt% ammonia water and 5 g of 3-mercaptopropyltrimethoxysilane, and stir the mixture at 30 °C in a N2 atmosphere for 6 h. The product is centrifuged, washed, and dried to obtain mercapto-silica.

[0053] (2) Add 4 g of dodecafluoroheptyl methacrylate and 5 g of vinylguanamine to 40 g of N,N-dimethylformamide and stir to obtain a mixed solution. Then disperse 10 g of mercaptosilane into the mixed solution and ultrasonically disperse for 10 min. Add 0.2 g of benzoin ethyl ether and ultrasonically disperse at a main wavelength of 365 nm and an intensity of 100 mW / cm 2 The mixture was reacted at 35°C for 50 min under ultraviolet light, and the product was centrifuged, washed with isopropanol, and dried to obtain a composite antibacterial agent.

[0054] (3) Weigh 2 g of safflower, 10 g of peach kernel, 10 g of forsythia, 11 g of chrysanthemum, 10 g of perilla, 22 g of platycodon, 9 g of star anise, 12 g of costus root, 8 g of agave root, 11 g of atractylodes, 11 g of white atractylodes, 11 g of green peel, 11 g of clove, 5 g of Zanthoxylum bungeanum, and 15 g of tea leaves, add them to a reaction vessel, then add 500 g of deionized water, and distill and extract at 96 ° C for 2.5 h to obtain the Chinese herbal medicine extract;

[0055] (4) Add 12g of rose hydrosol and 4g of mint hydrosol to 40g of Chinese herbal medicine extract to obtain the stock solution, dilute the stock solution 20 times, add 4g of borneol, stir thoroughly and filter to obtain the filtrate, add 3g of chelated platinum ions and 9g of compound antibacterial agent, stir evenly, and obtain the Chinese herbal medicine women's care solution. Example

[0056] A method for preparing a Chinese herbal medicine women's care solution comprises the following steps:

[0057] (1) Disperse 10 g of nano-silica in 50 g of 75 wt% ethanol aqueous solution, then add 8 g of 20 wt% ammonia water and 3 g of 3-mercaptopropyltrimethoxysilane, and stir the mixture at 20 °C in a N2 atmosphere for 5 h. The product is centrifuged, washed, and dried to obtain mercapto-silica.

[0058] (2) Add 2 g of dodecafluoroheptyl methacrylate and 4 g of vinylguanamine to 30 g of N,N-dimethylformamide and stir to obtain a mixed solution. Then disperse 10 g of mercaptosilane into the mixed solution and ultrasonically disperse for 5 min. Add 0.2 g of benzoin ethyl ether and ultrasonically disperse at a main wavelength of 365 nm and an intensity of 100 mW / cm 2 The mixture was reacted at 30°C for 30 min under ultraviolet light, and the product was centrifuged, washed with isopropanol, and dried to obtain a composite antibacterial agent;

[0059] (3) Weigh 2 g of safflower, 10 g of peach kernel, 10 g of forsythia, 11 g of chrysanthemum, 10 g of perilla, 22 g of platycodon, 9 g of star anise, 12 g of costus root, 8 g of agave root, 11 g of atractylodes, 11 g of white atractylodes, 11 g of green peel, 11 g of clove, 5 g of Zanthoxylum bungeanum, and 15 g of tea leaves, add them to a reaction vessel, then add 500 g of deionized water, and distill and extract at 96 ° C for 2.5 h to obtain the Chinese herbal medicine extract;

[0060] (4) Add 10g of rose hydrosol and 3g of mint hydrosol to 30g of Chinese herbal medicine extract to obtain the stock solution, dilute the stock solution 20 times and add 3g of borneol, stir thoroughly and filter to obtain the filtrate, add 1g of chelated platinum ions and 6g of compound antibacterial agent, stir evenly, and obtain the Chinese herbal medicine women's care solution.

[0061] A method for preparing a Chinese herbal medicine women's care solution comprises the following steps:

[0062] (1) Disperse 10 g of nano-silica in 70 g of 75 wt% ethanol aqueous solution, then add 17 g of 20 wt% ammonia water and 6 g of 3-mercaptopropyltrimethoxysilane, and stir the mixture at 35 °C in a N2 atmosphere for 8 h. The product is centrifuged, washed, and dried to obtain mercapto-silica.

[0063] (2) Add 5 g of dodecafluoroheptyl methacrylate to 50 g of N,N-dimethylformamide and stir to obtain a mixed solution. Then disperse 10 g of mercaptosilane into the mixed solution and ultrasonically disperse for 15 min. Add 0.2 g of benzoin ethyl ether and ultrasonically disperse at a main wavelength of 365 nm and an intensity of 100 mW / cm 2 The mixture was reacted at 40°C for 60 min under ultraviolet light, and the product was centrifuged, washed with isopropanol, and dried to obtain an antibacterial agent;

[0064] (3) Weigh 2 g of safflower, 10 g of peach kernel, 10 g of forsythia, 11 g of chrysanthemum, 10 g of perilla, 22 g of platycodon, 9 g of star anise, 12 g of costus root, 8 g of agave root, 11 g of atractylodes, 11 g of white atractylodes, 11 g of green peel, 11 g of clove, 5 g of Zanthoxylum bungeanum, and 15 g of tea leaves, add them to a reaction vessel, then add 500 g of deionized water, and distill and extract at 96 ° C for 2.5 h to obtain the Chinese herbal medicine extract;

[0065] (4) Add 15g of rose hydrosol and 5g of mint hydrosol to 45g of Chinese herbal medicine extract to obtain the stock solution. Dilute the stock solution by 20g and add 5g of borneol. Stir thoroughly and filter to obtain the filtrate. Add 5g of chelated platinum ions and 12g of antibacterial agent and stir evenly to obtain the Chinese herbal medicine women's care solution.

[0066] A method for preparing a Chinese herbal medicine women's care solution comprises the following steps:

[0067] (1) Disperse 10 g of nano-silica in 70 g of 75 wt% ethanol aqueous solution, then add 17 g of 20 wt% ammonia water and 6 g of 3-mercaptopropyltrimethoxysilane, and stir the mixture at 35 °C in a N2 atmosphere for 8 h. The product is centrifuged, washed, and dried to obtain mercapto-silica.

[0068] (2) Add 7g of vinylguanamine to 50g of N,N-dimethylformamide and stir to obtain a mixed solution. Then disperse 10g of mercaptosilane into the mixed solution and ultrasonically disperse for 15min. Add 0.2g of benzoin ethyl ether and ultrasonically disperse at a main wavelength of 365nm and an intensity of 100mW / cm 2 The mixture was reacted at 40°C for 60 min under ultraviolet light, and the product was centrifuged, washed with isopropanol, and dried to obtain an antibacterial agent;

[0069] (3) Weigh 2 g of safflower, 10 g of peach kernel, 10 g of forsythia, 11 g of chrysanthemum, 10 g of perilla, 22 g of platycodon, 9 g of star anise, 12 g of costus root, 8 g of agave root, 11 g of atractylodes, 11 g of white atractylodes, 11 g of green peel, 11 g of clove, 5 g of Zanthoxylum bungeanum, and 15 g of tea leaves, add them to a reaction vessel, then add 500 g of deionized water, and distill and extract at 96 ° C for 2.5 h to obtain the Chinese herbal medicine extract;

[0070] (4) Add 15g of rose hydrosol and 5g of mint hydrosol to 45g of Chinese herbal medicine extract to obtain the stock solution. Dilute the stock solution 20 times and add 5g of borneol. Stir thoroughly and filter to obtain the filtrate. Add 5g of chelated platinum ions and 12g of antibacterial agent and stir evenly to obtain the Chinese herbal medicine women's care solution.

[0071] A method for preparing a Chinese herbal medicine women's care solution comprises the following steps:

[0072] (1) Disperse 10 g of nano-silica in 70 g of 75 wt% ethanol aqueous solution, then add 17 g of 20 wt% ammonia water and 6 g of 3-mercaptopropyltrimethoxysilane, and stir the mixture at 35 °C in a N2 atmosphere for 8 h. The product is centrifuged, washed, and dried to obtain mercapto-silica.

[0073] (2) Weigh 2 g of safflower, 10 g of peach kernel, 10 g of forsythia, 11 g of chrysanthemum, 10 g of perilla, 22 g of platycodon, 9 g of star anise, 12 g of costus root, 8 g of agave root, 11 g of atractylodes, 11 g of white atractylodes, 11 g of green peel, 11 g of clove, 5 g of Zanthoxylum bungeanum, and 15 g of tea leaves, add them to a reaction vessel, then add 500 g of deionized water, and distill and extract at 96 ° C for 2.5 h to obtain the Chinese herbal medicine extract;

[0074] (3) Add 15g of rose hydrosol and 5g of mint hydrosol to 45g of Chinese herbal medicine extract to obtain the stock solution. Dilute the stock solution by 20g and add 5g of borneol. Stir thoroughly and filter to obtain the filtrate. Add 5g of chelated platinum ions and 12g of mercaptosilated silica and stir evenly to obtain the Chinese herbal medicine women's care solution.

[0075] Common female genital pathogens, including Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Bacillus subtilis, were selected as experimental strains. Each strain was activated in a broth medium at 37°C on a shaker at 150 rpm for 8 hours before use. The care solutions prepared in Examples 1-3 and Comparative Examples 1-3, sterilized at 121°C for 20 minutes, were added to sterile broth at a concentration of 0.05% (w / v). Under aseptic conditions, 1 mL of the activated bacterial solution (at a bacterial concentration of 109 cfu / mL) was added to 49 mL of the aforementioned culture medium and incubated at 37°C on a shaker at 150 rpm for 6 hours. The solution was then diluted and characterized by plate count according to GB 4789.2-2022, "National Food Safety Standard for Food Microbiology - Determination of Total Colony Counts." The sterilization rate was calculated according to the following formula: sterilization rate = (number of bacteria in the blank group - number of bacteria in the experimental group) / number of bacteria in the blank group, where the number of bacteria is expressed in cfu / mL. The test results are shown in Table 1.

[0076] Table 1 Bactericidal rate of the care solutions prepared in different examples (%)

[0077] The above description is only a preferred specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any technician familiar with the technical field, within the technical scope disclosed by the present invention, who makes equivalent replacements or changes based on the technical solution and inventive concept of the present invention, should be covered by the scope of protection of the present invention.

Claims

1. A Chinese herbal medicine women's care liquid formula, characterized in that: The composition is prepared from the following raw materials in parts by weight: 10-15 parts of rose hydrosol, 3-5 parts of mint hydrosol, 30-45 parts of Chinese herbal medicine extract, 3-5 parts of borneol, 1-5 parts of chelated platinum ions, and 6-12 parts of a composite antibacterial agent. The preparation method of the composite antibacterial agent comprises the following steps: (1) Dispersing nano-silica in an ethanol aqueous solution, then adding ammonia water and 3-mercaptopropyltrimethoxysilane, stirring to react, centrifuging, washing, and drying the product to obtain mercapto-silica; (2) Dodecafluoroheptyl methacrylate and vinylguanamine are added to N,N-dimethylformamide and stirred to obtain a mixed solution. Then, thiolated silica is dispersed in the mixed solution, ultrasonically dispersed, a photoinitiator is added, and the mixture is reacted under ultraviolet light. The product is centrifuged, washed with isopropyl alcohol, and dried to obtain a composite antibacterial agent.

2. The Chinese herbal medicine women's care solution formula according to claim 1, characterized in that: In step (1), the concentration of the ethanol aqueous solution is 50-75 wt %, and the concentration of the ammonia water is 15-25 wt %.

3. The Chinese herbal medicine women's care solution formula according to claim 1, characterized in that: In step (1), the weight ratio of nano-silica, ethanol aqueous solution, ammonia water, and 3-mercaptopropyltrimethoxysilane is 10:50~70:8~17:3~6.

4. The Chinese herbal medicine women's care solution formula according to claim 1, characterized in that: In step (1), the reaction conditions are 20-35°C in a N2 atmosphere for 5-8 hours.

5. The Chinese herbal medicine women's care solution formula according to claim 1, characterized in that: In step (2), the weight ratio of dodecafluoroheptyl methacrylate, vinylguanamine, N,N-dimethylformamide, and mercaptosilane is 2-5:4-7:30-50:

10.

6. The Chinese herbal medicine women's care solution formula according to claim 1, characterized in that: In step (2), the photoinitiator is one or more of benzoin dimethyl ether, benzoin ethyl ether, and benzoin butyl ether.

7. The Chinese herbal medicine women's care solution formula according to claim 1, characterized in that: In step (2), the ultrasonic dispersion time is 5-15 min, the main UV wavelength is 360-365 nm, and the UV intensity is 50-100 mW / cm 2 , irradiation time is 30~60min, and reaction temperature is 30~40℃.

8. The Chinese herbal medicine women's care solution formula according to claim 1, characterized in that: The preparation method of the Chinese herbal medicine extract comprises the following steps: weighing 1-2 parts of safflower, 8-12 parts of peach kernel, 8-12 parts of forsythia, 8-13 parts of chrysanthemum, 7-13 parts of perilla, 18-25 parts of platycodon, 8-11 parts of star anise, 9-14 parts of costus root, 7-12 parts of agave root, 10-12 parts of atractylodes, 10-12 parts of white atractylodes, 9-13 parts of green peel, 10-12 parts of clove, 4-6 parts of zanthoxylum bungeanum, and 13-16 parts of tea leaves, adding the mixture into a reaction container, then adding 500 parts of deionized water, and performing distillation extraction at 94-97°C for 1.5-3 hours to obtain the Chinese herbal medicine extract.

9. A method for preparing the Chinese herbal medicine women's care solution according to any one of claims 1 to 8, characterized in that: The method comprises the following steps: adding rose hydrosol and mint hydrosol to a Chinese herbal medicine extract to obtain a stock solution, diluting the stock solution and adding borneol, stirring thoroughly and filtering to obtain a filtrate, adding chelated platinum ions and a composite antibacterial agent, and stirring evenly to obtain a Chinese herbal women's care solution.

10. The preparation method according to claim 9, characterized in that The dilution ratio of the stock solution is 10~20 times.