Blood pressure data acquisition mechanism, electronic device, medical catheter and ablation system

Abstract

The application provides a blood pressure data acquisition mechanism, an electronic device, a medical catheter and an ablation system, which comprises a pressure sensor, a first valve, a second valve and a fluid passage, the opening and closing states of the first valve and the second valve are opposite; one end of the first valve is connected with the fluid passage, the other end of the first valve is used for being connected with a perfusion pump, when the first valve is in an open state and the second valve is in a closed state, the perfusion pump is connected with the fluid passage in communication to provide perfusion liquid to the fluid passage; the pressure sensor is connected with the fluid passage through the second valve, when the second valve is opened and the first valve is in a closed state, the pressure sensor is connected with the fluid passage in communication to acquire blood pressure data in a blood vessel where a target target point is located. The application can accurately acquire blood pressure data in the blood vessel while reducing damage in a surgical process, thereby laying a good foundation for realizing targeted ablation.

Description

Technical Field

[0001] The present invention relates to the technical field of medical equipment, and in particular to a blood pressure data acquisition mechanism, electronic equipment, a medical catheter and an ablation system. Background Art

[0002] Overactive nerves can adversely affect human organs and tissues, leading to a range of cardiovascular diseases. For example, chronic overactivation of the sympathetic nervous system can cause excessive secretion of renin, increased sodium ion reabsorption by the kidneys, increased cardiac output, and ultimately elevated blood pressure. If left uncontrolled, this vicious cycle can ultimately lead to high-risk cardiovascular events such as heart failure and stroke.

[0003] Currently, a method has been proposed to treat hypertension by performing radiofrequency ablation of the renal artery using a radiofrequency ablation catheter, namely renal sympathetic denervation (RDN) surgery. This surgery uses radiofrequency heating to block the sympathetic nervous system around the renal artery, reducing sympathetic nerve tone, thereby achieving the therapeutic effect of long-term lowering blood pressure. Its principles can be simply summarized in two aspects: (1) By inhibiting the activity of sympathetic afferent nerve fibers, it can inhibit the overexcited sympathetic system throughout the body, thereby inhibiting abnormal vascular contraction, inhibiting abnormal heart rate increases, and ultimately achieving blood pressure control; (2) On the other hand, by inhibiting the activity of renal sympathetic efferent nerves, it can inhibit the excessive release of renin, thereby weakening the influence of the renin-angiotensin-aldosterone system on abnormally elevated systemic blood pressure.

[0004] RDN surgery involves catheterization via the femoral artery to access the bilateral renal arteries. Radiofrequency, ultrasound, or microwave energy is released in a controlled manner through the catheter in a selected area, causing localized hyperthermia in the renal artery lining, thereby blocking the conduction function of some sympathetic nerve fibers in the renal artery wall. Currently, RDN surgery still faces a significant challenge. Although clinical results from second-generation RDN have consistently shown that surgery can significantly reduce blood pressure, in all clinical studies, a small number of patients in the surgical group experience an increase in blood pressure rather than a decrease. With the recent development of RDN surgery, basic research in the field has gradually revealed the reasons for this phenomenon: (1) insufficient sympathetic denervation. Almost all studies have shown that only blocking a certain proportion of sympathetic nerves can achieve a blood pressure-lowering effect; and (2) parasympathetic innervation. In recent years, an increasing number of basic studies have identified evidence of parasympathetic innervation around the renal arteries using various methods. Due to the mutual checks and balances between parasympathetic innervation and sympathetic nerves, blind ablation of parasympathetic nerves can cause the previously suppressed sympathetic nerves to take over, thereby worsening symptoms in patients with hypertension.

[0005] During RDN surgical treatment, the blood pressure changes caused by the energy output at a fixed position have some characteristics that are positively correlated with the nerve types and their distribution around that position. Therefore, the characteristics of the blood pressure changes at the energy output position can be used to judge the surrounding nerve types and their distribution to achieve targeted ablation.

[0006] Therefore, it is particularly important to provide a solution for accurately obtaining blood pressure (blood flow pressure) data in blood vessels (such as renal arteries).

[0007] It should be noted that the information disclosed in the background technology section of the invention is only intended to deepen the understanding of the general background technology of the invention, and should not be regarded as an admission or any form of implication that the information constitutes prior art already known to those skilled in the art. Summary of the Invention

[0008] The purpose of the present invention is to provide a blood pressure data acquisition mechanism, electronic equipment, medical catheter and ablation system, which can accurately obtain blood pressure data in blood vessels while reducing damage during surgery, thereby laying a good foundation for achieving targeted ablation.

[0009] To achieve the above-mentioned objectives, the present invention provides a blood pressure data acquisition mechanism, which includes a pressure sensor, a first valve, a second valve, and a fluid passage, wherein the switching state of the first valve is opposite to the switching state of the second valve; one end of the first valve is connected to the fluid passage, and the other end of the first valve is used to be connected to an infusion pump. When the first valve is in an open state and the second valve is in a closed state, the infusion pump is connected to the fluid passage to provide infusion fluid to the fluid passage, and the fluid passage can transport the infusion fluid to a target point; the pressure sensor is connected to the fluid passage through the second valve. When the second valve is open and the first valve is in a closed state, the pressure sensor is connected to the fluid passage to collect blood pressure data in the blood vessel where the target point is located.

[0010] Optionally, the second valve is a three-way valve, and when the second valve is in a closed state, the pressure sensor is connected to the outside atmosphere.

[0011] Optionally, the first valve includes a first knob, a first valve body, and a first valve core located in the first valve body, the first valve core is connected to the first knob, and the first knob can drive the first valve core to rotate to control the switching state of the first valve; the second valve includes a second knob, a second valve body, and a second valve core located in the second valve body, the second valve core is connected to the second knob, and the second knob can drive the second valve core to rotate to control the switching state of the second valve.

[0012] Optionally, the blood pressure data acquisition mechanism also includes a rotating handle, which includes a rotating rod and a third knob connected to one end of the rotating rod, the first knob and the second knob are both engaged with the third knob, and the third knob can drive the first knob and the second knob to rotate to open one of the first valve and the second valve and close the other of the first valve and the second valve.

[0013] Optionally, the rotating handle further includes a handle portion connected to the other end of the rotating rod.

[0014] To achieve the above object, the present invention further provides an electronic device, comprising a processor and a memory, wherein the memory stores a computer program, and when the computer program is executed by the processor, the following steps are implemented:

[0015] Acquiring blood pressure data of the target point before and during stimulation, wherein the blood pressure data is acquired by the blood pressure data acquisition mechanism described in any one of the above items;

[0016] Drawing a blood pressure baseline based on the blood pressure data before the target point is stimulated;

[0017] A blood pressure change trend line is drawn based on the blood pressure data during the stimulation of the target point.

[0018] Optionally, drawing a blood pressure baseline based on the blood pressure data before the target point is stimulated includes:

[0019] Obtaining systolic blood pressure data of the target point before being stimulated according to the blood pressure data of the target point before being stimulated;

[0020] Obtaining a baseline systolic blood pressure value based on the systolic blood pressure data before the target point is stimulated;

[0021] Draw a systolic blood pressure baseline based on the baseline systolic blood pressure value; or

[0022] Obtaining diastolic pressure data of the target point before being stimulated according to the blood pressure data of the target point before being stimulated;

[0023] Obtaining a baseline diastolic blood pressure value according to the diastolic blood pressure data before the target point is stimulated;

[0024] Based on the baseline diastolic blood pressure value, a diastolic blood pressure baseline is drawn.

[0025] Optionally, drawing a blood pressure change trend line based on the blood pressure data during the stimulation of the target point includes:

[0026] Acquiring systolic blood pressure data during the stimulation of the target point according to the blood pressure data during the stimulation of the target point;

[0027] performing polynomial regression on the systolic blood pressure data during the stimulation of the target point;

[0028] Drawing a systolic blood pressure change trend line based on the result of polynomial regression of the systolic blood pressure data during the stimulation of the target point; or

[0029] Acquiring diastolic pressure data during the stimulation of the target point according to the blood pressure data during the stimulation of the target point;

[0030] performing polynomial regression on the diastolic pressure data during the stimulation of the target point;

[0031] A diastolic pressure change trend line is drawn based on the result of the polynomial regression of the diastolic pressure data during the stimulation of the target point.

[0032] Optionally, obtain systolic blood pressure data by following these steps:

[0033] Dividing the blood pressure data into a plurality of blood pressure data segments according to a preset time window;

[0034] For each of the blood pressure data segments:

[0035] Find out all peak blood pressures in the blood pressure data segment;

[0036] For each peak blood pressure in this blood pressure data segment:

[0037] Finding the left boundary blood pressure and the right boundary blood pressure corresponding to the peak blood pressure in the blood pressure data segment;

[0038] Finding a first minimum blood pressure between the peak blood pressure and its left boundary blood pressure, and a second minimum blood pressure between the peak blood pressure and its right boundary blood pressure in the blood pressure data segment;

[0039] calculating the left protrusion of the peak blood pressure according to the difference between the peak blood pressure and the first minimum blood pressure;

[0040] calculating the right protrusion of the peak blood pressure according to the difference between the peak blood pressure and the second minimum blood pressure;

[0041] According to the left protrusion and right protrusion of the peak blood pressure, determine whether the peak blood pressure is systolic blood pressure;

[0042] Based on all of the systolic blood pressures, systolic blood pressure data is obtained.

[0043] Optionally, searching for the left boundary blood pressure corresponding to the peak blood pressure in the blood pressure data segment includes:

[0044] determining whether there is at least one peak blood pressure in the blood pressure data segment located to the left of the peak blood pressure;

[0045] If not, the first blood pressure in the blood pressure data segment is used as the left boundary blood pressure corresponding to the peak blood pressure;

[0046] If so, the peak blood pressures located on the left side of the peak blood pressure are traversed one by one in the blood pressure data segment from right to left until the currently traversed peak blood pressure is greater than or equal to the peak blood pressure. The currently traversed peak blood pressure is then used as the left boundary blood pressure corresponding to the peak blood pressure.

[0047] Optionally, searching for the right boundary blood pressure corresponding to the peak blood pressure in the blood pressure data segment includes:

[0048] determining whether there is at least one peak blood pressure in the blood pressure data segment located to the right of the peak blood pressure;

[0049] If not, the last blood pressure in the blood pressure data segment is used as the right boundary blood pressure corresponding to the peak blood pressure;

[0050] If so, the peak blood pressures located to the right of the peak blood pressure are traversed one by one in the blood pressure data segment from left to right until the currently traversed peak blood pressure is greater than or equal to the peak blood pressure. The currently traversed peak blood pressure is then used as the right boundary blood pressure corresponding to the peak blood pressure.

[0051] Optionally, judging whether the peak blood pressure is systolic pressure based on the left protrusion and the right protrusion of the peak blood pressure includes:

[0052] If the smaller of the left protrusion and the right protrusion of the peak blood pressure is greater than a preset protrusion threshold, the peak blood pressure is determined to be systolic pressure.

[0053] Optionally, when the computer program is executed by a processor, the following steps are further implemented:

[0054] According to the blood pressure change trend line during the stimulation of the target point, the peak blood pressure and the trough blood pressure during the stimulation of the target point are obtained.

[0055] To achieve the above objectives, the present invention also provides a medical catheter, which includes a catheter body and the blood pressure data acquisition mechanism described in any one of the above items, wherein the fluid passage is arranged in the catheter body and the fluid passage extends along the axial direction of the catheter body.

[0056] Optionally, the medical catheter further includes a handle connected to the proximal end of the catheter body, and the pressure sensor, the first valve and the second valve are all disposed in the handle.

[0057] To achieve the above objectives, the present invention further provides an ablation system, which includes the electronic device described in any one of the above items or the medical catheter described in any one of the above items.

[0058] Compared with the prior art, the blood pressure data acquisition mechanism, electronic equipment, medical catheter, and ablation system provided by the present invention have the following beneficial effects:

[0059] The blood pressure data acquisition mechanism provided by the present invention includes a pressure sensor, a first valve, a second valve, and a fluid pathway. The on / off state of the first valve is opposite to that of the second valve. One end of the first valve is connected to the fluid pathway, and the other end of the first valve is connected to an infusion pump. When the first valve is open and the second valve is closed, the infusion pump communicates with the fluid pathway to provide perfusion fluid to the fluid pathway, and the fluid pathway is capable of delivering the perfusion fluid to a target site. The pressure sensor is connected to the fluid pathway via the second valve. When the second valve is open and the first valve is closed, the pressure sensor communicates with the fluid pathway to acquire blood pressure data within the blood vessel where the target site is located. Because fluids transmit pressure, when the second valve is open and the first valve is closed, the pressure within the blood vessel is transmitted to the pressure sensor via the liquid (perfusion fluid) within the fluid pathway, thereby enabling acquisition of blood pressure data within the blood vessel. Because the present invention utilizes interconnected pressure sensors and fluid pathways to collect blood pressure data, it can reduce the number of puncture sites required during surgery. This allows accurate acquisition of intravascular blood pressure data while minimizing surgical damage, laying a solid foundation for targeted ablation. Furthermore, because the blood pressure data acquisition mechanism provided by the present invention ensures that the blood pressure data is collected closer to the target point (energy interference location), the accuracy of the acquired blood pressure data can be effectively guaranteed.

[0060] Since the electronic device, medical catheter and ablation system provided by the present invention belong to the same inventive concept as the blood pressure data acquisition mechanism provided by the present invention, the electronic device, medical catheter and ablation system provided by the present invention at least have all the beneficial effects of the blood pressure data acquisition mechanism provided by the present invention. Therefore, for the relevant content about the beneficial effects of the electronic device, medical catheter and ablation system provided by the present invention, please refer to the relevant description of the beneficial effects of the blood pressure data acquisition mechanism provided by the present invention in the above text, and will not be repeated here one by one. BRIEF DESCRIPTION OF THE DRAWINGS

[0061] Figure 1 A schematic diagram of the overall structure of a blood pressure data acquisition mechanism provided in one embodiment of the present invention;

[0062] Figure 2 A schematic diagram of a blood pressure data acquisition mechanism provided by one embodiment of the present invention when the first valve is in an open state and the second valve is in a closed state;

[0063] Figure 3 A schematic diagram of a blood pressure data acquisition mechanism provided by one embodiment of the present invention when the first valve is in a closed state and the second valve is open;

[0064] Figure 4 A schematic diagram of the connection relationship between the rotating handle, the first valve, and the second valve in the blood pressure data acquisition mechanism provided in one embodiment of the present invention;

[0065] Figure 5 A schematic diagram illustrating the state switching between the first valve and the second valve in the blood pressure data acquisition mechanism provided in one embodiment of the present invention;

[0066] Figure 6 A schematic cross-sectional view of a medical catheter provided in one embodiment of the present invention;

[0067] Figure 7 A schematic block diagram of an electronic device according to an embodiment of the present invention;

[0068] Figure 8 A schematic diagram of steps that can be implemented by the electronic device provided by the present invention;

[0069] Figure 9 A schematic diagram of blood pressure changes before and after stimulation energy intervention provided in a specific example of the present invention;

[0070] Figure 10 A blood pressure variation curve diagram within a single cardiac cycle provided by a specific example of the present invention;

[0071] Figure 11 A schematic diagram of a systolic blood pressure determination process according to one embodiment of the present invention;

[0072] Figure 12a A schematic diagram of the protrusion calculation principle provided for a specific example of the present invention;

[0073] Figure 12b A schematic diagram of protrusion calculation principle provided for another specific example of the present invention;

[0074] Figure 13 A schematic block diagram of an ablation system provided in one embodiment of the present invention.

[0075] The description of the accompanying drawings is as follows:

[0076] Medical catheter 1000; catheter body 1200; electrical signal path 1210; guide wire 1211; pull wire path 1220; handle 1300;

[0077] Pressure sensor 1110 ; first valve 1120 ; first knob 1121 ; first valve body 1122 ; first valve core 1123 ; second valve 1130 ; second knob 1131 ; second valve body 1132 ; second valve core 1133 ; fluid passage 1140 ; ​​rotary handle 1150 ; rotary rod 1151 ; third knob 1152 ; handle 1153 ;

[0078] Equipment components-2000;

[0079] Electronic device 2100; processor 2110; communication interface 2120; memory 2130; communication bus 2140;

[0080] Energy output device-2200;

[0081] Irrigation pump-3000;

[0082] Vascular-4000;

[0083] Original blood pressure change curve - 12; blood pressure baseline - 13; systolic blood pressure change trend line - 14; trough blood pressure - 15; peak blood pressure - 16; peak blood pressure - 17a, 17b, 17c. DETAILED DESCRIPTION

[0084] The blood pressure data acquisition mechanism, electronic device, medical catheter and ablation system proposed in the present invention are further described in detail below in conjunction with the accompanying drawings and specific embodiments. According to the following description, the advantages and features of the present invention will be clearer. It should be noted that the drawings are in a very simplified form and are not in precise proportions, which are only used to conveniently and clearly assist in explaining the purpose provided by the present invention. In order to make the purpose, features and advantages of the present invention more obvious and easy to understand, please refer to the drawings. It should be noted that the structures, proportions, sizes, etc. illustrated in the drawings of this specification are only used to match the contents disclosed in the specification for people familiar with this technology to understand and read, and are not used to limit the conditions for the implementation of the present invention. Any modification of the structure, change in the proportional relationship or adjustment of the size should still fall within the scope of the technical content disclosed in the present invention when the effect produced by the present invention and the purpose achieved are the same or similar.

[0085] It should be noted that, in this document, relational terms such as first and second, etc., are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply the existence of any such actual relationship or order between these entities or operations. Moreover, the terms "comprises," "comprising," or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article, or device comprising a series of elements includes not only those elements, but also other elements not explicitly listed, or elements inherent to such process, method, article, or device. In the absence of further limitations, an element defined by the phrase "comprising a ..." does not exclude the presence of other identical elements in the process, method, article, or device comprising the element. The singular forms "a", "an" and "the" include plural objects, the term "or" is generally used in a sense including "and / or", the term "several" is generally used in a sense including "at least one", and the term "at least two" is generally used in a sense including "two or more". In addition, the terms "first", "second" and "third" are used for descriptive purposes only and cannot be understood as indicating or suggesting relative importance or implicitly indicating the number of the indicated technical features.

[0086] In addition, in the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art can combine and combine different embodiments or examples described in this specification and the features of different embodiments or examples without contradiction.

[0087] The core idea of ​​the present invention is to provide a blood pressure data acquisition mechanism, electronic equipment, medical catheter and ablation system, which can accurately obtain blood pressure data in blood vessels while reducing damage during surgery, thereby laying a good foundation for achieving targeted ablation.

[0088] It should be noted that the blood pressure data acquisition mechanism provided by the present invention can be applied to the medical catheter provided by the present invention, and the electronic device and medical catheter provided by the present invention can be applied to the ablation system provided by the present invention. The electronic device can be integrated with the energy output device of the ablation system, or can be independently provided separately from the energy output device. It should also be noted that, as will be understood by those skilled in the art, the "proximal end" referred to in the present invention refers to the end closest to the operator, i.e., the end away from the target site. Furthermore, it should be noted that the "blood vessel" referred to in the present invention can include, but is not limited to, blood vessels such as the renal artery and the pulmonary artery.

[0089] To realize the above idea, the present invention provides a blood pressure data acquisition mechanism, electronic equipment, medical catheter and ablation system, please refer to Figures 1 to 3 ,in, Figure 1 A schematic diagram of the overall structure of a blood pressure data acquisition mechanism provided in one embodiment of the present invention; Figure 2 A schematic diagram of a blood pressure data acquisition mechanism provided by one embodiment of the present invention when the first valve is in an open state and the second valve is in a closed state; Figure 3 This is a schematic diagram of a blood pressure data acquisition mechanism provided by one embodiment of the present invention when the first valve is in a closed state and the second valve is open. Figures 1 to 3As shown, the blood pressure data acquisition mechanism includes a pressure sensor 1110, a first valve 1120, a second valve 1130 and a fluid passage 1140. The switching state of the first valve 1120 is opposite to the switching state of the second valve 1130. One end of the first valve 1120 is connected to the fluid passage 1140, and the other end of the first valve 1120 is used to connect to the perfusion pump 3000. When the first valve 1120 is in the open state and the second valve 1130 is in the closed state, the perfusion pump 3000 000 is connected to the fluid pathway 1140 to provide perfusion fluid to the fluid pathway 1140, and the fluid pathway 1140 can transport the perfusion fluid to the target point; the pressure sensor 1110 is connected to the fluid pathway 1140 through the second valve 1130. When the second valve 1130 is opened and the first valve 1120 is in a closed state, the pressure sensor 1110 is connected to the fluid pathway 1140 to collect blood pressure data in the blood vessel 4000 where the target point is located.

[0090] Since the fluid has the function of transmitting pressure, when the second valve 1130 is opened and the first valve 1120 is in a closed state, the pressure in the blood vessel 4000 will be transmitted to the pressure sensor 1110 through the liquid (perfusion fluid) in the fluid passage 1140, thereby collecting blood pressure data in the blood vessel 4000. Since the present invention utilizes the connected pressure sensor 1110 and fluid passage 1140 to collect blood pressure data, the number of puncture positions that the patient needs to undergo during the operation can be reduced, thereby accurately obtaining blood pressure data in the blood vessel 4000 while reducing damage during the operation, thereby laying a good foundation for achieving targeted ablation. In addition, since the blood pressure data collection mechanism provided by the present invention can ensure that the collection position of the blood pressure data is closer to the target target (energy interference position), the accuracy of the blood pressure data obtained can be effectively guaranteed.

[0091] Please continue to refer to Figure 2 and Figure 3 ,like Figure 2 and Figure 3 As shown, in some exemplary embodiments, the first valve 1120 is a conventional valve (a two-way valve), and the second valve 1130 is a three-way valve. When the second valve 1130 is closed, the pressure sensor 1110 is connected to the outside atmosphere. Thus, by configuring the second valve 1130 as a three-way valve and allowing the pressure sensor 1110 to be connected to the outside atmosphere when the second valve 1130 is closed, the pressure sensor 1110 can be calibrated using standard atmospheric pressure, thereby further ensuring the accuracy of the blood pressure data collected by the pressure sensor 1110.

[0092] Specifically, if Figure 2 As shown, when the first valve 1120 is in the open state and the second valve 1130 is in the closed state, the perfusion pump 3000 is connected to the blood vessel 4000 through the fluid path 1140 and is isolated from the pressure sensor 1110. At this time, the perfusion fluid (e.g., saline) can enter the blood vessel 4000 through the fluid path 1140 under the action of the perfusion pump 3000, thereby achieving the perfusion function of the perfusion fluid (e.g., saline). At the same time, the pressure sensor 1110 can be connected to the atmosphere through the second valve 1130, so that the pressure sensor 1110 can be calibrated using standard atmospheric pressure. Figure 3 As shown, when the first valve 1120 is closed and the second valve 1130 is open, the pressure sensor 1110 is connected to the blood vessel 4000 via the fluid pathway 1140 and isolated from the atmosphere and the perfusion pump 3000. The pressure within the blood vessel 4000 is transmitted to the pressure sensor 1110 via the perfusion fluid (e.g., saline). The pressure sensor 1110 converts changes in blood pressure into voltage changes (e.g., each +1 mmHg pressure change results in a +5 μV output voltage change), and transmits the voltage changes via the wire 1211 in the electrical signal pathway 1210 to the electronic device 2100, which then converts the received voltage changes into changes in blood pressure.

[0093] It should be noted that, as can be understood by those skilled in the art, the state of the second valve 1130 when it is connected to the pressure sensor 1110 and the fluid passage 1140 is referred to as an open state, and the state of the second valve 1130 when it is connected to the pressure sensor 1110 and the external atmosphere is referred to as a closed state.

[0094] Please continue to refer to Figures 1 to 3 ,like Figures 1 to 3 As shown, the first valve 1120 includes a first knob 1121, a first valve body 1122, and a first valve core 1123 located in the first valve body 1122. The first valve core 1123 is connected to the first knob 1121, and the first knob 1121 can drive the first valve core 1123 to rotate to control the on / off state of the first valve 1120. Thus, the operator can rotate the first knob 1121 to drive the first valve core 1123 to rotate, thereby connecting or disconnecting two connection ports (not shown in the figure, one of which is connected to the perfusion pump 3000 and the other is connected to the fluid passage 1140) on the first valve body 1122, thereby controlling the opening or closing of the first valve 1120.

[0095] Please continue to refer to Figures 1 to 3,like Figures 1 to 3 As shown, in some exemplary embodiments, the second valve 1130 includes a second knob 1131, a second valve body 1132, and a second valve core 1133 located within the second valve body 1132. The second valve core 1133 is connected to the second knob 1131. The second knob 1131 can drive the second valve core 1133 to rotate to control the on / off state of the second valve 1130. Thus, an operator can rotate the second knob 1131 to drive the second valve core 1133 to rotate, thereby controlling the opening or closing of the second valve 1130.

[0096] Specifically, when the second valve 1130 is a three-way valve, a first interface, a second interface and a third interface are provided on the second valve body 1132, wherein the first interface is connected to the pressure sensor 1110, the second interface is connected to the fluid passage 1140, and the third interface is connected to the outside atmosphere. When the second knob 1131 drives the second valve core 1133 to rotate to a position where the first interface is connected to the second interface, the second valve 1130 is in an open state; when the second knob 1131 drives the second valve core 1133 to rotate to a position where the first interface is connected to the third interface, the second valve 1130 is in a closed state.

[0097] Please continue to refer to Figure 1 、 Figure 4 and Figure 5 ,in, Figure 4 A schematic diagram of the connection relationship between the rotating handle, the first valve, and the second valve in the blood pressure data acquisition mechanism provided in one embodiment of the present invention; Figure 5 This is a schematic diagram showing the state switching principle of the first valve and the second valve in the blood pressure data acquisition mechanism provided in one embodiment of the present invention. Figure 1 、 Figure 4 and Figure 5As shown, in some exemplary embodiments, the blood pressure data acquisition mechanism provided by the present invention also includes a rotating handle 1150, which includes a rotating rod 1151 and a third knob 1152 connected to one end of the rotating rod 1151, and the first knob 1121 and the second knob 1131 are both engaged with the third knob 1152, and the third knob 1152 can drive the first knob 1121 and the second knob 1131 to rotate to open one of the first valve 1120 and the second valve 1130 and close the other of the first valve 1120 and the second valve 1130. Because the first knob 1121 and the second knob 1131 are both engaged with the third knob 1152 on the rotating handle 1150, when the operator rotates the rotating handle 1150, the first knob 1121 and the second knob 1131 can be simultaneously driven to rotate in opposite directions, thereby controlling the opening of the first valve 1120 and the closing of the second valve 1130, or controlling the closing of the first valve 1120 and the opening of the second valve 1130. Thus, by providing the rotating handle 1150, the states of the first valve 1120 and the second valve 1130 can be switched simultaneously, thereby making operation more convenient.

[0098] Specifically, if Figure 4 and Figure 5 As shown, by rotating the rotating handle 1150 counterclockwise, the first valve 1120 can be opened. Figure 4 The open state shown switches to Figure 5 The closed state shown in FIG. Figure 4 The closed state shown switches to Figure 5 Shown in open state.

[0099] Please continue to refer to Figure 1 ,like Figure 1 As shown, in some exemplary embodiments, the rotating handle 1150 further includes a handle portion 1153 connected to the other end of the rotating rod 1151. Thus, the operator can rotate the handle portion 1153 to drive the rotating rod 1151 and the third knob 1152 to rotate, thereby more easily driving the first knob 1121 and the second knob 1131 to rotate in opposite directions.

[0100] It should be noted that, as can be understood by those skilled in the art, in some other embodiments, the first valve 1120 and the second valve 1130 can also be solenoid valves, in which case the rotary handle 1150 can not be provided and the first valve 1120 can not be provided with the first knob 1121, and the second valve 1130 can not be provided with the second knob 1131, but the opening and closing states of the first valve 1120 and the second valve 1130 can be controlled by energization and de-energization.

[0101] Based on the same inventive concept, the present application also provides a medical catheter, please refer to Figure 6 , which is a schematic view of the cross-sectional structure of the medical catheter provided by an embodiment of the present application. As shown in Figure 6 , the medical catheter 1000 comprises a catheter body 1200 and the blood pressure data acquisition mechanism according to any one of the above embodiments, the fluid passage 1140 is arranged in the catheter body 1200, and the fluid passage 1140 extends along the axial direction of the catheter body 1200. Since the medical catheter 1000 provided by the present application comprises the blood pressure data acquisition mechanism provided by the present application, the medical catheter 1000 provided by the present application can reduce the number of puncture positions that the patient needs to accept during the operation, thereby accurately acquiring the blood pressure data in the blood vessel 4000 while reducing the damage during the operation, so as to lay a good foundation for realizing targeted ablation. In addition, the medical catheter 1000 provided by the present application can ensure that the blood pressure data acquisition position is closer to the target point (energy interference position), thereby effectively ensuring the accuracy of the acquired blood pressure data.

[0102] In some exemplary embodiments, the medical catheter 1000 further comprises a handle 1300 connected to the proximal end of the catheter body 1200, and the pressure sensor 1110, the first valve 1120 and the second valve 1130 are all arranged in the handle 1300 (see Figure 1 ). Thus, by arranging the pressure sensor 1110, the first valve 1120 and the second valve 1130 in the handle 1300 of the medical catheter 1000, the internal space of the handle 1300 can be fully utilized, thereby effectively simplifying the overall structure of the medical catheter 1000.

[0103] It should be noted that, as can be understood by those skilled in the art, one of the interfaces (third interface) of the second valve 1130 can be connected to the outside atmosphere through a gas pipeline, one end of the gas pipeline connected to the second valve 1130 is located in the handle 1300, and the other end of the gas pipeline extends to the outside of the handle 1300.

[0104] Please continue to refer to Figure 6 , as Figure 6 As shown, in some exemplary embodiments, the medical catheter 1000 further includes an electrical signal path 1210 extending axially along the catheter body 1200. The electrical signal path 1210 is isolated from the fluid path 1140. Thus, by providing the electrical signal path 1210 on the catheter body 1200, which is isolated from the fluid path 1140, a wire 1211 for transmitting an electrical signal can be arranged within the electrical signal path 1210. This not only facilitates wiring but also prevents contact between the wire 1211 and the liquid in the fluid path 1140, thereby effectively improving the safety of the medical catheter 1000 during use.

[0105] Please continue to refer to Figure 6 ,like Figure 6 As shown, in some exemplary embodiments, the medical catheter 1000 further includes a pull wire passage 1220 extending axially along the catheter body 1200. Thus, a pull wire can be arranged in the pull wire passage 1220, thereby enabling the catheter body 1200 to be bent by manipulating the pull wire, thereby improving the maneuverability of the catheter body 1200.

[0106] It should be noted that, as those skilled in the art will appreciate, if there is ample space within the catheter body 1200, two mutually isolated fluid passages 1140 may be provided within the catheter body 1200, thereby enabling simultaneous acquisition of pressure at two different locations within the blood vessel 4000. It should also be noted that, as those skilled in the art will appreciate, further details regarding the structure of the medical catheter 1000 can be found in the relevant literature known to those skilled in the art in the field of ablation catheters, and will not be further described here.

[0107] Based on the same inventive concept, the present invention also provides an electronic device, please refer to Figure 7 and Figure 8 ,in, Figure 7 A schematic block diagram of an electronic device according to an embodiment of the present invention; Figure 8 Schematic diagram of the steps that can be implemented by the electronic device provided by the present invention. Figure 7 and Figure 8 As shown, the electronic device 2100 includes a processor 2110 and a memory 2130. The memory 2130 stores a computer program. When the computer program is executed by the processor 2110, the following steps are implemented:

[0108] Step S100: Obtaining blood pressure data of the target point before and during stimulation.

[0109] Step S200: Draw a blood pressure baseline 13 based on the blood pressure data of the target point before stimulation.

[0110] Step S300: drawing a blood pressure change trend line based on the blood pressure data during the stimulation of the target point.

[0111] The blood pressure data is collected by the blood pressure data collection mechanism described above.

[0112] Since the blood pressure data is collected by adopting the blood pressure data collection mechanism provided by the present invention, the accuracy of the obtained blood pressure data can be effectively guaranteed, and thus the accuracy of the blood pressure baseline 13 drawn based on the blood pressure data before the target target is stimulated and the blood pressure change trend line drawn based on the blood pressure data during the stimulation of the target target can be guaranteed, thereby providing a basis for accurately judging whether the target target is an ablation target, laying a good foundation for achieving targeted ablation, and thus effectively reducing the difficulty of the ablation surgery and shortening the operation time.

[0113] It should be noted that although Figure 8 The example of first executing step S100, then executing step S200, and finally executing step S300 is used for explanation. However, as those skilled in the art will appreciate, this does not constitute a limitation to the present invention. In other embodiments, step S200 may be executed immediately after obtaining the blood pressure data of the target point before stimulation, or step S200 and step S300 may be executed simultaneously after executing step S100.

[0114] In some exemplary embodiments, step S200 of drawing a blood pressure baseline 13 based on the blood pressure data of the target point before stimulation includes:

[0115] Obtaining systolic blood pressure data of the target point before being stimulated according to the blood pressure data of the target point before being stimulated;

[0116] Obtaining a baseline systolic blood pressure value based on the systolic blood pressure data before the target point is stimulated;

[0117] Based on the baseline systolic blood pressure value, a systolic blood pressure baseline is plotted.

[0118] Specifically, the systolic blood pressure data of the target point before stimulation can be obtained based on the blood pressure data within a preset time period before the target point is stimulated (for example, within 10 seconds before stimulation), and then the baseline systolic blood pressure value can be obtained based on the average of the systolic blood pressure data before stimulation of the target point. The systolic blood pressure baseline (for example, Figure 9 As shown, Figure 9This is a schematic diagram of blood pressure changes before and after stimulation energy intervention provided for a specific example of the present invention, where 12 in the figure represents the original blood pressure change curve).

[0119] In some exemplary embodiments, step S300 of drawing a blood pressure trend line based on the blood pressure data during the stimulation of the target point includes:

[0120] Acquiring systolic blood pressure data during the stimulation of the target point according to the blood pressure data during the stimulation of the target point;

[0121] performing polynomial regression on the systolic blood pressure data during the stimulation of the target point;

[0122] A systolic blood pressure change trend line 14 is drawn based on the result of the polynomial regression of the systolic blood pressure data during the stimulation of the target point.

[0123] Thus, by first obtaining the systolic blood pressure data of the target point during the stimulation process based on the blood pressure data of the target point during the stimulation process, and then performing polynomial regression on the systolic blood pressure data of the target point during the stimulation process, a continuously changing and smoother systolic blood pressure change trend line 14 (such as Figure 9 As shown), the influence of extreme systolic pressure on the systolic pressure change trend line 14 is avoided, and the interference of data fluctuation on subsequent ablation target judgment is reduced.

[0124] Specifically, polynomial regression can be performed on the systolic blood pressure data during the stimulation of the target point according to the following formula (1):

[0125] sbp=f(t)=w n ×t n +w n-1 ×t n-1 +…+w1×t+w0×b (1)

[0126] Where sbp represents systolic / diastolic blood pressure, t is the stimulation time, w0, w1, ..., w n-1 、w n Represents the weight of each class, and b is a constant term.

[0127] Furthermore, the degree n of the polynomial is determined by the number m of systolic pressures (i.e., how many cardiac cycles have occurred during the stimulation energy output process, i.e., during the stimulation process of the target point). Specifically, the degree n of the polynomial can be determined according to the following formula (2):

[0128]

[0129] In the formula, int means rounding.

[0130] It should be noted that, since under normal circumstances the blood pressure in a single stimulation energy interference process (single stimulation process) will not fluctuate (change in direction) more than three times, the maximum value of the degree n of the polynomial is limited to no more than 4.

[0131] Furthermore, the weights w0, w1, ..., w of each class in the polynomial can be determined according to the following formula (3): n-1 、w n :

[0132]

[0133] Where:

[0134]

[0135] Among them, (t1,y1), (t2,y2),…, (t m ,y m ), which are respectively the acquisition time of m groups of systolic blood pressure and their corresponding pressure values ​​during the stimulation of the target point.

[0136] The w0, w1, ..., w calculated based on formula (3) n-1 、w m By substituting the weights of each class into the above formula (1), the relationship between systolic pressure and time during the energy interference process can be obtained, and the systolic pressure change trend line 14 can be drawn based on the relationship.

[0137] It should be noted that the specific process of polynomial regression in the present invention is similar to that of traditional linear regression, and both are iterative calculation processes based on minimizing the difference between the actual value and the expected value. For more information on how to perform polynomial regression on the systolic blood pressure data during the stimulation of the target point, reference can be made to relevant content in the field of polynomial regression known to those skilled in the art, and will not be described in detail here.

[0138] It should also be noted that, as those skilled in the art will appreciate, in some other embodiments, the systolic blood pressure change trend line 14 may be drawn using a moving average method. Specifically, the trend line 14 is drawn from the first systolic blood pressure after the stimulation energy intervention starts (stimulation starts, t=0s) to the next 10 systolic blood pressures (SBP1 to SBP2). 1+9 ), (SBP2 to SBP 2+9 ) ..., and so on, the average values ​​are calculated respectively and connected to obtain the systolic blood pressure trend line 14. However, the method of drawing the systolic blood pressure trend line 14 by using the moving average method is easily affected by extreme systolic blood pressure.

[0139] Furthermore, in the prior art, a detection algorithm is generally used to identify the highest blood pressure (systolic blood pressure) within a single cardiac cycle. Currently, there are a large number of algorithms for implementing such functions, and their basic principles are mostly similar, that is, by selecting the time when the slope changes to determine the peak value (e.g., bp i ≥bp i-1 And bp i ≥bp i+1 , then the signal level at time i can be defined as the peak value, that is, the blood pressure at time i can be defined as the systolic pressure). However, in actual applications, multiple peak values ​​may appear in a single cardiac cycle, for example, Figure 10 As shown ( Figure 10 (A blood pressure change curve diagram within a single cardiac cycle provided for a specific example of the present invention) Blood pressure 17a and blood pressure 17b both meet the conditions for being peak blood pressure, but only blood pressure 17a correctly represents the systolic blood pressure level within the cardiac cycle, and blood pressure 17b can only represent the peak value within a local range.

[0140] Commonly used methods for identifying global peaks within a cycle (e.g. Figure 10 Blood pressure in 17a) and local peak (such as Figure 10 Methods for determining blood pressure in 17b) include: 1. directly setting the peak value range; 2. specifying the minimum spacing between two peaks; 3. setting the peak frequency within a fixed time period; and 4. setting the peak duration. Because blood pressure and heart rate can fluctuate significantly in practice, directly specifying the peak value range, minimum spacing, and frequency is inappropriate. Furthermore, because there is no significant difference in the duration of local and global peaks, determining systolic blood pressure based on peak duration is also inappropriate.

[0141] To solve the above problem, in some exemplary embodiments, the present invention obtains systolic blood pressure data through the following steps:

[0142] Dividing the blood pressure data into a plurality of blood pressure data segments according to a preset time window;

[0143] For each of the blood pressure data segments:

[0144] Find out all peak blood pressures in the blood pressure data segment;

[0145] For each peak blood pressure in this blood pressure data segment:

[0146] Finding the left boundary blood pressure and the right boundary blood pressure corresponding to the peak blood pressure in the blood pressure data segment;

[0147] Finding a first minimum blood pressure between the peak blood pressure and its left boundary blood pressure, and a second minimum blood pressure between the peak blood pressure and its right boundary blood pressure in the blood pressure data segment;

[0148] calculating the left protrusion of the peak blood pressure according to the difference between the peak blood pressure and the first minimum blood pressure;

[0149] calculating the right protrusion of the peak blood pressure according to the difference between the peak blood pressure and the second minimum blood pressure;

[0150] According to the left protrusion and right protrusion of the peak blood pressure, determine whether the peak blood pressure is systolic blood pressure;

[0151] Based on all of the systolic blood pressures, systolic blood pressure data is obtained.

[0152] Therefore, the present invention can effectively avoid misjudgment of systolic pressure caused by local peaks in a single cardiac cycle by judging whether the peak blood pressure is systolic pressure based on the prominence of the peak blood pressure, and effectively improve the accuracy of the obtained systolic pressure data.

[0153] It should be noted that, as those skilled in the art will appreciate, the method of determining the peak value by selecting the moment when the slope change occurs, as described above, can be used to find all peak blood pressures in each blood pressure data segment. Furthermore, it should be noted that, as those skilled in the art will appreciate, the duration of the preset time window can be set according to actual needs, but the duration of the preset time window should be greater than one cardiac cycle. For example, the duration of the preset time window can be set to 2.5 seconds, and the duration of each blood pressure data segment is 2.5 seconds.

[0154] In some exemplary embodiments, searching for the left boundary blood pressure corresponding to the peak blood pressure in the blood pressure data segment includes:

[0155] determining whether there is at least one peak blood pressure in the blood pressure data segment located to the left of the peak blood pressure;

[0156] If not, the first blood pressure in the blood pressure data segment is used as the left boundary blood pressure corresponding to the peak blood pressure;

[0157] If so, the peak blood pressures located on the left side of the peak blood pressure are traversed one by one in the blood pressure data segment from right to left until the currently traversed peak blood pressure is greater than or equal to the peak blood pressure. The currently traversed peak blood pressure is then used as the left boundary blood pressure corresponding to the peak blood pressure.

[0158] Therefore, by taking the peak blood pressure that is greater than or equal to the peak blood pressure and located on the left side of the peak blood pressure as the left boundary blood pressure corresponding to the peak blood pressure, misjudgment of the local peak in a single cardiac cycle can be further avoided.

[0159] It should be noted that if all peak blood pressures on the left side of the peak blood pressure in the blood pressure data segment are lower than the peak blood pressure, the first blood pressure in the blood pressure data segment will also be used as the left boundary blood pressure corresponding to the peak blood pressure.

[0160] In some exemplary embodiments, searching for the right boundary blood pressure corresponding to the peak blood pressure in the blood pressure data segment includes:

[0161] determining whether there is at least one peak blood pressure in the blood pressure data segment located to the right of the peak blood pressure;

[0162] If not, the last blood pressure in the blood pressure data segment is used as the right boundary blood pressure corresponding to the peak blood pressure;

[0163] If so, the peak blood pressures located to the right of the peak blood pressure are traversed one by one in the blood pressure data segment from left to right until the currently traversed peak blood pressure is greater than or equal to the peak blood pressure. The currently traversed peak blood pressure is then used as the right boundary blood pressure corresponding to the peak blood pressure.

[0164] Therefore, by taking the peak blood pressure that is greater than or equal to the peak blood pressure and located on the right side of the peak blood pressure as the right boundary blood pressure corresponding to the peak blood pressure, misjudgment of the local peak in a single cardiac cycle can be further avoided.

[0165] It should be noted that if all peak blood pressures on the right side of the peak blood pressure in the blood pressure data segment are lower than the peak blood pressure, the last blood pressure in the blood pressure data segment will also be used as the right boundary blood pressure corresponding to the peak blood pressure.

[0166] In some exemplary embodiments, determining whether the peak blood pressure is systolic pressure based on the left protrusion and the right protrusion of the peak blood pressure includes:

[0167] If the smaller of the left protrusion and the right protrusion of the peak blood pressure is greater than a preset protrusion threshold, the peak blood pressure is determined to be systolic pressure.

[0168] Specifically, when the smaller of the left and right protrusions of the peak blood pressure is greater than a preset protrusion threshold, it indicates that the protrusions on both sides of the peak blood pressure are close to the overall amplitude of the blood pressure signal, and therefore the peak blood pressure can be determined as systolic. When the smaller of the left and right protrusions of the peak blood pressure is less than or equal to the preset protrusion threshold, it indicates that the protrusion on one side of the peak blood pressure is smaller than the overall amplitude of the blood pressure signal, and therefore the peak blood pressure can be determined as a local peak blood pressure, rather than systolic.

[0169] It should be noted that the protrusion threshold can be set according to the overall amplitude of the blood pressure signal, and the present invention does not limit the specific value of the protrusion threshold.

[0170] Please continue to refer to Figure 11 , which is a schematic diagram of the systolic blood pressure determination process provided by one embodiment of the present invention. Figure 11 As shown, for each blood pressure data segment, first, all peak blood pressures in the blood pressure data segment are found. Then, starting from i=1, the other peak blood pressures (blood pressures other than the i-th peak blood pressure) located to the right of the i-th peak blood pressure in the blood pressure data segment are traversed one by one from left to right until the other peak blood pressure currently traversed is greater than or equal to the i-th peak blood pressure. In this case, the other peak blood pressure currently traversed is used as the right boundary blood pressure j corresponding to the i-th peak blood pressure. Similarly, the other peak blood pressures located to the left of the i-th peak blood pressure in the blood pressure data segment are traversed one by one from right to left until the other peak blood pressure currently traversed is greater than or equal to the i-th peak blood pressure. In this case, the other peak blood pressure currently traversed is used as the left boundary blood pressure k corresponding to the i-th peak blood pressure. Furthermore, if there are no other peak blood pressures on the right side of the i-th peak blood pressure or no other peak blood pressure greater than or equal to the i-th peak blood pressure, the last blood pressure in the blood pressure data segment is used as the right boundary blood pressure j of the i-th peak blood pressure; if there are no other peak blood pressures on the left side of the i-th peak blood pressure or no other peak blood pressure greater than or equal to the i-th peak blood pressure, the first blood pressure in the blood pressure data segment is used as the left boundary blood pressure k of the i-th peak blood pressure. After determining the right boundary blood pressure j and the left boundary blood pressure k of the i-th peak blood pressure, the right protrusion of the i-th peak blood pressure is calculated according to the following formula (4), and the left protrusion of the i-th peak blood pressure is calculated according to the following formula (5):

[0171] P right =Amplitude i -min(Amplitude i:j ) (4)

[0172] P left=Amplitude i -min(Amplitude k:i ) (5)

[0173] Where, P right is the right protrusion of the ith peak blood pressure, P left Amplitude is the left protrusion of the i-th peak blood pressure, i is the ith peak blood pressure, min(Amplitude i:j ) is the minimum blood pressure (i.e., the second minimum blood pressure) between the i-th peak blood pressure and its right boundary blood pressure j in the blood pressure data segment, min(Amplitude k:i ) is the minimum blood pressure (i.e., the first minimum blood pressure) between the i-th peak blood pressure and its left boundary blood pressure k in the blood pressure data segment.

[0174] After calculating the right protrusion P of the i-th peak blood pressure right and left protrusion P left Then, the right protrusion P right and left protrusion P left The smaller one of the two is taken as the prominence P of the i-th peak blood pressure i (That is, P i =min(P right , P left )). If the prominence of the i-th peak blood pressure P i Greater than the preset protrusion threshold P threshold (i.e. P i >P threshold ), the i-th peak blood pressure is determined as the global peak blood pressure, that is, the i-th peak blood pressure is determined as the systolic pressure; otherwise, the i-th peak blood pressure is determined as the local peak blood pressure (non-systolic pressure).

[0175] Please continue to refer to Figure 12a and Figure 12b ,in, Figure 12a A schematic diagram of the protrusion calculation principle provided for a specific example of the present invention; Figure 12b The protrusion calculation principle diagram provided for another specific example of the present invention. For the peak blood pressure 17a, since it is greater than the peak blood pressure 17b, the right boundary blood pressure j will be calculated according to Figure 11 The determination process shown in FIG is extended to the next peak blood pressure 17c that is greater than the peak blood pressure 17c. Since there is no other peak blood pressure on its left side, the first blood pressure in the blood pressure data segment in which it is located is used as its left boundary blood pressure k. Based on its right boundary blood pressure j and left boundary blood pressure k, the left protrusion P of the peak blood pressure 17a can be calculated. left and the right protrusion P right (like Figure 12aAs shown in Figure 2, both peak blood pressures are close to the overall amplitude of the blood pressure signal, so peak blood pressure 17a can be used as systolic pressure. On the other hand, peak blood pressure 17b is smaller than both peak blood pressures 17a and 17c on its two sides. Therefore, peak blood pressure 17a can be used as its left boundary blood pressure k, and peak blood pressure 17c can be used as its right boundary blood pressure j. Based on its right boundary blood pressure j and left boundary blood pressure k, the left protrusion P of peak blood pressure 17b can be calculated. left and the right protrusion P right (like Figure 12b As shown), due to the left protrusion P of the peak blood pressure 17b left Smaller than the right protrusion P right And the left protrusion P left The overall amplitude of the blood pressure signal is smaller than that of the blood pressure signal, so the peak blood pressure 17b is determined to be a local peak blood pressure rather than a systolic pressure.

[0176] In some exemplary embodiments, when the computer program is executed by a processor, the following steps are further implemented:

[0177] According to the blood pressure change trend line during the stimulation of the target point, the peak blood pressure 16 and the trough blood pressure 15 during the stimulation of the target point are obtained.

[0178] Therefore, by obtaining the peak blood pressure 16 and trough blood pressure 15 during the stimulation of the target target based on the blood pressure change trend line during the stimulation of the target target, the operator can accurately determine whether the target target is an ablation target based on the peak blood pressure 16 and trough blood pressure 15 during the stimulation of the target target.

[0179] It should be noted that, as can be understood by those skilled in the art, the peak blood pressure 16 refers to the highest blood pressure on the blood pressure trend line, and the trough blood pressure 15 refers to the lowest blood pressure on the blood pressure trend line.

[0180] In some other exemplary embodiments, the step S200 of drawing the blood pressure baseline 13 based on the blood pressure data of the target point before stimulation includes:

[0181] Obtaining diastolic pressure data of the target point before being stimulated according to the blood pressure data of the target point before being stimulated;

[0182] Obtaining a baseline diastolic blood pressure value according to the diastolic blood pressure data before the target point is stimulated;

[0183] Based on the baseline diastolic blood pressure value, a diastolic blood pressure baseline is drawn.

[0184] Specifically, the diastolic pressure data before the target point is stimulated can be obtained according to the blood pressure data within a preset time period (for example, within 10 seconds) before the target point is stimulated, and the baseline diastolic pressure value can be obtained according to the mean value of the diastolic pressure data before the target point is stimulated, and the diastolic pressure baseline can be drawn according to the baseline diastolic pressure value.

[0185] It should be noted that, as can be understood by those skilled in the art, the identification of diastolic pressure can use similar logic as systolic pressure, and specific adaptive understanding can be made with reference to the related content of the above-mentioned systolic pressure data acquisition step, which will not be described here. In addition, a simpler identification method can also be used: that is, in the case where the systolic pressure has been identified, the minimum blood pressure between the adjacent two systolic pressures is the diastolic pressure.

[0186] In some other exemplary embodiments, the step S300 of drawing a blood pressure change trend line according to the blood pressure data during stimulation of the target point comprises:

[0187] According to the blood pressure data during stimulation of the target point, diastolic pressure data during stimulation of the target point is obtained;

[0188] The diastolic pressure data during stimulation of the target point is subjected to polynomial regression;

[0189] According to the result of polynomial regression of the diastolic pressure data during stimulation of the target point, a diastolic pressure change trend line is drawn.

[0190] Therefore, by first obtaining the diastolic pressure data during stimulation of the target point according to the blood pressure data during stimulation of the target point, and then subjecting the diastolic pressure data during stimulation of the target point to polynomial regression, a diastolic pressure change trend line that changes continuously and is smoother can be drawn according to the result of the polynomial regression, thereby avoiding the influence of extreme diastolic pressure on the diastolic pressure change trend line and reducing the interference of data fluctuations on subsequent ablation target point judgment.

[0191] It should be noted that, as can be understood by those skilled in the art, the specific content of how to perform polynomial regression on the diastolic pressure data can be adaptively understood with reference to the related content of how to perform polynomial regression on the systolic pressure data, which will not be described here.

[0192] It should also be noted that, as can be understood by those skilled in the art, in some other embodiments, the diastolic pressure change trend line can also be drawn by using a moving average (MovingAverage) method. Specifically, starting from the first diastolic pressure after the start of stimulation energy interference (start of stimulation, t=0s) to the next 10 diastolic pressures... and so on, their average values ​​are calculated respectively and connected to obtain the diastolic pressure change trend line.

[0193] Please continue to refer to Figure 8 ,like Figure 8 As shown, the electronic device 2100 further includes a communication interface 2120 and a communication bus 2140, wherein the processor 2110, the communication interface 2120, and the memory 2130 communicate with each other via the communication bus 2140. The communication bus 2140 may be a Peripheral Component Interconnect (PCI) bus or an Extended Industry Standard Architecture (EISA) bus, etc. The communication bus 2140 may be divided into an address bus, a data bus, a control bus, etc. For ease of illustration, only one thick line is used in the figure, but this does not mean that there is only one bus or one type of bus. The communication interface 2120 is used for communication between the electronic device 2100 and other devices.

[0194] The processor 2110 referred to in the present invention may be a central processing unit (CPU), or other general-purpose processors, digital signal processors (DSP), application-specific integrated circuits (ASIC), field-programmable gate arrays (FPGA), or other programmable logic devices, discrete gate or transistor logic devices, discrete hardware components, etc. A general-purpose processor may be a microprocessor or any conventional processor, etc. The processor 2110 is the control center of the electronic device 2100, and connects various parts of the entire electronic device 2100 using various interfaces and lines.

[0195] The memory 2130 may be used to store the computer program, and the processor 2110 implements various functions of the electronic device 2100 by running or executing the computer program stored in the memory 2130 and calling the data stored in the memory 2130 .

[0196] The memory 2130 can include nonvolatile and / or volatile memory. Nonvolatile memory can include read-only memory (ROM), programmable memory (PROM), electrically programmable memory (EPROM), electrically erasable programmable memory (EEPROM), or flash memory. Volatile memory can include random-access memory (RAM), or external cache memory. Random-access memory is available in many forms, such as static random-access memory (SRAM), dynamic random-access memory (DRAM), synchronous random-access memory (SDRAM), double data rate synchronous random-access memory (DDR SDRAM), enhanced synchronous random-access memory (ESDRAM), Synchlink dynamic random-access memory (SLDRAM), Rambus direct random-access memory (RDRAM), direct memory bus dynamic random-access memory (DRDRAM), and Rambus dynamic random-access memory (RDRAM), among others.

[0197] Based on the same inventive concept, the present application also provides an ablation system, which comprises the electronic device 2100 described above and / or the medical catheter 1000 described above. Since the ablation system provided by the present application comprises the electronic device 2100 and / or the medical catheter 1000 provided by the present application, the ablation system provided by the present application at least has all the beneficial effects of the electronic device 2100 and / or the medical catheter 1000 provided by the present application, and specific reference can be made to the relevant description of the beneficial effects of the electronic device 2100 and / or the medical catheter 1000 provided by the present application above, which will not be repeated here.

[0198] Please continue to refer to Figure 13 which is a block structure schematic diagram of the ablation system provided by an embodiment of the present application. As shown in Figure 13 In some exemplary embodiments, the ablation system further comprises an energy output device 2200 electrically connected with the electronic device 2100 and the medical catheter 1000, and the energy output device 2200 is configured to provide stimulation energy or ablation energy to the medical catheter 1000 to stimulate or ablate the target target point.

[0199] Specifically, taking the renal artery as an example, the connection between the device assembly 2000, consisting of the electronic device 2100 and the energy output device 2200, the medical catheter 1000, and the human body can be described as the device assembly 2000 outputting ablative and / or non-ablative intervention (stimulation) energy to the medical catheter 1000. The medical catheter 1000 then enters the body via a unilateral femoral artery puncture and transmits the energy to the vessel wall within the renal artery via the metal wire 1211 within the electrical signal pathway 1210. The impedance and temperature (thermocouple signal) of the vessel wall tissue are also fed back to the device assembly 2000 via the metal wire 1211 within the electrical signal pathway 1210 of the medical catheter 1000. The connection between the perfusion pump 3000, the medical catheter 1000, and the human body can be described as the perfusion pump 3000 pumping physiological saline at a constant rate into the medical catheter 1000. The medical catheter 1000 then enters the body via a unilateral femoral artery puncture and delivers the physiological saline to the renal artery via the fluid pathway 1140. By switching the connection between the perfusion pump 3000, the fluid pathway 1140 and the human body to the connection between the pressure sensor 1110, the fluid pathway 1140 and the human body, the pressure changes in the blood vessel 4000 can be transmitted to the pressure sensor 1110 through the liquid in the fluid pathway 1140 (such as saline), thereby obtaining a dynamic waveform of the real-time pressure changes in the blood vessel 4000. The pressure sensor 1110 can convert the pressure changes in blood pressure into voltage changes (for example, every +1 mmHg pressure change will result in a +5 μV output voltage change) and send it to the electronic device 2100. The electronic device 2100 can directly obtain blood pressure data through the original digital signal (voltage change) fed back by the pressure sensor 1110 and the established conversion relationship (for example, every +1 mmHg pressure change will result in a +5 μV output voltage change).

[0200] It should be noted that, as those skilled in the art will appreciate, the stimulation energy or ablation energy provided by the energy output device 2200 may be, but is not limited to, radiofrequency energy, pulse energy, ultrasonic energy, and the like.

[0201] In summary, compared with the prior art, the blood pressure data acquisition mechanism, electronic device, medical catheter, and ablation system provided by the present invention have the following beneficial effects:

[0202] (1) The present invention collects blood pressure data by utilizing the interconnected pressure sensor 1110 and fluid path 1140, thereby reducing the number of puncture sites required of the patient during surgery. This allows accurate acquisition of blood pressure data within the blood vessel 4000 while minimizing surgical damage, thereby laying a good foundation for targeted ablation. Furthermore, because the blood pressure data acquisition mechanism provided by the present invention ensures that the blood pressure data acquisition location is closer to the target point (energy interference location), the accuracy of the acquired blood pressure data can be effectively guaranteed.

[0203] (2) The present invention performs polynomial regression on the systolic pressure data / diastolic pressure data during the stimulation of the target point, thereby being able to draw a continuously changing and smoother systolic pressure change trend line 14 / diastolic pressure change trend line, thereby avoiding the influence of extreme systolic pressure / diastolic pressure on the systolic pressure change trend line 14 / diastolic pressure change trend line, and reducing the interference of data fluctuations on subsequent ablation target judgment.

[0204] (3) The present invention determines whether the peak blood pressure is systolic pressure based on the prominence of the peak blood pressure, which can effectively avoid the misjudgment of systolic pressure caused by local peaks in a single cardiac cycle and effectively improve the accuracy of the obtained systolic pressure data.

[0205] It should be noted that the computer program code for performing the operations of the present invention can be written in one or more programming languages ​​or a combination thereof, including object-oriented programming languages ​​such as Java, Smalltalk, C++, and conventional procedural programming languages ​​such as "C" or similar programming languages. The program code can be executed entirely on the user's computer, partially on the user's computer, as a separate software package, partially on the user's computer and partially on a remote computer, or entirely on a remote computer or server. In cases involving a remote computer, the remote computer can be connected to the user's computer through any type of network, including a local area network (LAN) or a wide area network (WAN), or can be connected to an external computer (e.g., through the Internet using an Internet service provider).

[0206] It should be noted that the devices and methods disclosed in the embodiments of this document may also be implemented in other ways. The device embodiments described above are merely illustrative. For example, the flowcharts and block diagrams in the accompanying drawings show the possible architectures, functions, and operations of the devices, methods, and computer program products according to the various embodiments of this document. In this regard, each box in the flowchart or block diagram may represent a module, program, or part of the code, which contains one or more executable instructions for implementing the specified logical functions. It should also be noted that in some alternative implementations, the functions marked in the boxes may also occur in an order different from that marked in the accompanying drawings. For example, two consecutive boxes may actually be executed substantially in parallel, or they may sometimes be executed in the opposite order, depending on the functions involved. It should also be noted that each box in the block diagram and / or flowchart, and the combination of boxes in the block diagram and / or flowchart, may be implemented by a dedicated hardware-based system for performing the specified functions or actions, or may be implemented by a combination of dedicated hardware and computer instructions. In addition, the functional modules in the various embodiments of this document may be integrated together to form an independent part, or each module may exist independently, or two or more modules may be integrated to form an independent part.

[0207] It should also be noted that the above description is merely a description of preferred embodiments of the present invention and does not limit the scope of the present invention. Any changes or modifications made by persons skilled in the art based on the above disclosure are within the scope of protection of the present invention. Obviously, various modifications and variations may be made by persons skilled in the art without departing from the spirit and scope of the present invention. Thus, provided such modifications and variations fall within the scope of the present invention and its equivalents, the present invention is intended to include such modifications and variations.

Claims

1. An electronic device, characterized in that: The system comprises a processor and a memory, wherein the memory stores a computer program, and when the computer program is executed by the processor, the following steps are implemented: Acquiring blood pressure data of the target point before and during stimulation, wherein the blood pressure data is collected by a blood pressure data collection mechanism; Drawing a blood pressure baseline based on the blood pressure data before the target point is stimulated; Drawing a blood pressure change trend line based on the blood pressure data during the stimulation of the target point; The blood pressure data acquisition mechanism includes a pressure sensor, a first valve, a second valve, and a fluid passage, wherein the switching state of the first valve is opposite to the switching state of the second valve; One end of the first valve is connected to the fluid passage, and the other end of the first valve is used to be connected to an infusion pump. When the first valve is in an open state and the second valve is in a closed state, the infusion pump is connected to the fluid passage to provide infusion fluid to the fluid passage, and the fluid passage is capable of delivering the infusion fluid to the target site. The pressure sensor is connected to the fluid passage through the second valve. When the second valve is open and the first valve is closed, the pressure sensor is connected to the fluid passage to collect blood pressure data in the blood vessel where the target point is located. When the computer program is executed by the processor, systolic blood pressure data is obtained by the following steps: Dividing the blood pressure data into a plurality of blood pressure data segments according to a preset time window; For each of the blood pressure data segments: Find out all peak blood pressures in the blood pressure data segment; For each peak blood pressure in this blood pressure data segment: Finding the left boundary blood pressure and the right boundary blood pressure corresponding to the peak blood pressure in the blood pressure data segment; Finding a first minimum blood pressure between the peak blood pressure and its left boundary blood pressure, and a second minimum blood pressure between the peak blood pressure and its right boundary blood pressure in the blood pressure data segment; calculating the left protrusion of the peak blood pressure according to the difference between the peak blood pressure and the first minimum blood pressure; calculating the right protrusion of the peak blood pressure according to the difference between the peak blood pressure and the second minimum blood pressure; According to the left protrusion and right protrusion of the peak blood pressure, determine whether the peak blood pressure is systolic blood pressure; Based on all of the systolic blood pressures, systolic blood pressure data is obtained.

2. The electronic device according to claim 1, wherein The second valve is a three-way valve. When the second valve is in a closed state, the pressure sensor is connected to the outside atmosphere.

3. The electronic device according to claim 1, wherein The first valve includes a first knob, a first valve body, and a first valve core located in the first valve body, wherein the first valve core is connected to the first knob, and the first knob can drive the first valve core to rotate to control the on / off state of the first valve; The second valve includes a second knob, a second valve body, and a second valve core located in the second valve body. The second valve core is connected to the second knob, and the second knob can drive the second valve core to rotate to control the switching state of the second valve.

4. The electronic device according to claim 3, wherein: The blood pressure data acquisition mechanism also includes a rotating handle, which includes a rotating rod and a third knob connected to one end of the rotating rod. The first knob and the second knob are both engaged with the third knob. The third knob can drive the first knob and the second knob to rotate to open one of the first valve and the second valve and close the other of the first valve and the second valve.

5. The electronic device according to claim 4, characterized in that The rotating handle further includes a handle portion connected to the other end of the rotating rod.

6. The electronic device according to claim 1, wherein: Drawing a blood pressure baseline based on the blood pressure data before the target point is stimulated includes: Obtaining systolic blood pressure data of the target point before being stimulated according to the blood pressure data of the target point before being stimulated; Obtaining a baseline systolic blood pressure value based on the systolic blood pressure data before the target point is stimulated; Draw a systolic blood pressure baseline based on the baseline systolic blood pressure value; or Obtaining diastolic pressure data of the target point before being stimulated according to the blood pressure data of the target point before being stimulated; Obtaining a baseline diastolic blood pressure value according to the diastolic blood pressure data before the target point is stimulated; Based on the baseline diastolic blood pressure value, a diastolic blood pressure baseline is drawn.

7. The electronic device according to claim 1, wherein: Drawing a blood pressure change trend line based on the blood pressure data during the stimulation of the target point includes: Acquiring systolic blood pressure data during the stimulation of the target point according to the blood pressure data during the stimulation of the target point; performing polynomial regression on the systolic blood pressure data during the stimulation of the target point; Drawing a systolic blood pressure change trend line based on the result of polynomial regression of the systolic blood pressure data during the stimulation of the target point; or Acquiring diastolic pressure data during the stimulation of the target point according to the blood pressure data during the stimulation of the target point; performing polynomial regression on the diastolic pressure data during the stimulation of the target point; A diastolic pressure change trend line is drawn based on the result of the polynomial regression of the diastolic pressure data during the stimulation of the target point.

8. The electronic device according to claim 1, wherein: The step of searching for the left boundary blood pressure corresponding to the peak blood pressure in the blood pressure data segment includes: determining whether there is at least one peak blood pressure in the blood pressure data segment located to the left of the peak blood pressure; If not, the first blood pressure in the blood pressure data segment is used as the left boundary blood pressure corresponding to the peak blood pressure; If so, the peak blood pressures located on the left side of the peak blood pressure are traversed one by one in the blood pressure data segment from right to left until the currently traversed peak blood pressure is greater than or equal to the peak blood pressure. The currently traversed peak blood pressure is then used as the left boundary blood pressure corresponding to the peak blood pressure.

9. The electronic device according to claim 1, wherein: The step of searching for the right boundary blood pressure corresponding to the peak blood pressure in the blood pressure data segment includes: determining whether there is at least one peak blood pressure in the blood pressure data segment located to the right of the peak blood pressure; If not, the last blood pressure in the blood pressure data segment is used as the right boundary blood pressure corresponding to the peak blood pressure; If so, the peak blood pressures located to the right of the peak blood pressure are traversed one by one in the blood pressure data segment from left to right until the currently traversed peak blood pressure is greater than or equal to the peak blood pressure. The currently traversed peak blood pressure is then used as the right boundary blood pressure corresponding to the peak blood pressure.

10. The electronic device according to claim 1, wherein The step of determining whether the peak blood pressure is systolic pressure based on the left protrusion and the right protrusion of the peak blood pressure includes: If the smaller of the left protrusion and the right protrusion of the peak blood pressure is greater than a preset protrusion threshold, the peak blood pressure is determined to be systolic pressure.

11. The electronic device according to claim 1, wherein When the computer program is executed by a processor, the following steps are further implemented: According to the blood pressure change trend line during the stimulation of the target point, the peak blood pressure and the trough blood pressure during the stimulation of the target point are obtained.

12. An ablation system, characterized in that: The electronic device comprises the electronic device according to any one of claims 1 to 11.

Images