A left atrial appendage occlusion component

Abstract

The present invention relates to a left atrial appendage occluding assembly, comprising a first sheath tube, a second sheath tube and an occluding member, wherein the first sheath tube is used to deliver an adhesive material to the bottom of the left atrial appendage to form an adhesive layer; the occluding member is arranged in the second sheath tube, and the occluding member is pushed out from the distal end of the second sheath tube and released into the left atrial appendage by a push rod, so that part of the occluding member is inserted into the adhesive material at the bottom of the left atrial appendage, and when the adhesive material is solidified to form an adhesive layer, the adhesive layer can lock the occluding member; the occluding member comprises a plug connector and a compressible occluding block, the occluding block is connected to the plug connector, and the occluding block can be compressed; the plug connector is coaxially arranged with the occluding block, the plug connector is connected to the occluding block, the plug connector is used to be inserted into the adhesive material, and the occluding member has a compressed state and a natural state. The occluding member can be fixed in the left atrial appendage to effectively block the left atrial appendage, and after blocking, a cavity structure will not be formed in the left atrial appendage, and the situation of falling off will hardly occur, thereby improving the surgical effect.

Description

Technical Field

[0001] The invention belongs to the field of medical technology, and in particular relates to a left atrial appendage occlusion component. Background Art

[0002] Atrial fibrillation is the most common arrhythmia in clinical practice. With the development of minimally invasive interventional surgery, left atrial appendage closure (LAAC) can effectively prevent non-valvular atrial fibrillation stroke. Currently, the commonly used occluders are basically based on nickel-titanium alloy wires, represented by Watchman's plug occluder and Amplatzer's disc occluder. These occluders are non-degradable occluders with high metal modulus and high hardness. After long-term implantation, they will cause wear on surrounding tissues; some people are allergic to the precipitated metal Ni ions; after occlusion, a cavity structure is formed, and the traction force generated by the contraction and relaxation of the heart may cause the occluder to dislodge. Summary of the invention

[0003] In view of this, the present invention provides a left atrial appendage occlusion component, which can fix an occlusion piece in the left atrial appendage to effectively occlude the left atrial appendage. After occlusion, no cavity structure will be formed in the left atrial appendage and it will hardly fall off, thereby improving the surgical effect.

[0004] The technical solution adopted by the present invention is:

[0005] A left atrial appendage occluding assembly is used for occluding the left atrial appendage, comprising a first sheath tube, a second sheath tube and an occluding piece, wherein the first sheath tube is used for conveying an adhesive material to the bottom of the left atrial appendage to form an adhesive layer; the occluding piece is arranged in the second sheath tube, and the occluding piece is pushed out from the distal end of the second sheath tube and released into the left atrial appendage by a push rod, so that a part of the occluding piece is inserted into the adhesive material at the bottom of the left atrial appendage, and when the adhesive material is cured to form an adhesive layer, the adhesive layer can lock the occluding piece;

[0006] The plugging member comprises a plug connector and a compressible plugging block, the plug connector is connected to the plug connector, the plugging block can be compressed, and in a natural state, the plugging block is columnar, and the radial dimension of the plugging block is substantially consistent with the internal dimension of the left atrial appendage; the plug connector is coaxially arranged with the plugging block, the plug connector is connected to the plugging block, the plug connector is used to be inserted into the adhesive material, and the plugging member has a compressed state and a natural state;

[0007] In the compressed state, the blocking block is radially compressed so that the radial dimension of the blocking block is consistent with the inner diameter of the second sheath tube, so that the blocking piece can be transmitted through the second sheath tube;

[0008] In the natural state, the blocking block is expanded into a columnar shape to block the left atrial appendage.

[0009] Preferably, the diameter of the plug connector is slightly smaller than the inner diameter of the second sheath tube;

[0010] The blocking piece also includes a skeleton, which includes a central rod connected to each other and a stopper connected to one end of the central rod, the central rod is inserted at the center of the blocking block, the central rod and the blocking block are coaxially arranged, the other end of the central rod is connected to the plug connector, and the stopper abuts against one end of the blocking block away from the plug connector to limit the position of the blocking block.

[0011] Preferably, the skeleton and the plug connector are integrally formed, the skeleton and the plug connector are obtained by 3D printing using PDO material, and the plug connector is hollow.

[0012] Preferably, the radial dimension of the stopper is consistent with the radial dimension of the plug connector;

[0013] The stopper comprises a plurality of stop rods, each of the stop rods having a first end and a second end, the first ends of all the stop rods being connected to one another at the same point, which is a center point, the axes of the plurality of stop rods being located in the same plane, and the plurality of stop rods being evenly arranged around the center point; one end of the center rod being connected to the center point;

[0014] The diameter of the central rod is smaller than the diameter of the plug connector, and the side of the blocking block close to the plug connector abuts against the end of the plug connector.

[0015] Preferably, the plug connector comprises a small diameter section and a large diameter section connected to each other, one end of the small diameter section facing away from the large diameter section is connected to the other end of the center rod, and the ratio of the length of the small diameter section to the large diameter section is (5-10):1.

[0016] Preferably, the blocking block is made of biodegradable polyurethane foam.

[0017] Preferably, the adhesive material comprises an adhesive and a developing material, the adhesive is one or more of fibrin glue, polydopamine-type polyurethane adhesive, amino-containing polyester polyurethane adhesive, poly (N-isopropylacrylamide) adhesive; the developing material is one or more of tantalum nanoparticles, bismuth oxide, bismuth basic carbonate and barium sulfate;

[0018] The mass ratio of the developing material to the binder is (5-10):100.

[0019] Preferably, it also includes a first puncture catheter and a second puncture catheter, which are used to pass through the artery and puncture the atrial septum of the heart, and leave a first guide wire of the first puncture catheter and a second guide wire of the second puncture catheter, so as to facilitate guiding the first sheath along the first guide wire so that the distal end of the first sheath reaches the left atrium, and guiding the second sheath along the second guide wire so that the distal end of the second sheath reaches the left atrium.

[0020] Beneficial effects of the present invention:

[0021] When the present invention is used to perform left atrial appendage occlusion, the first and second puncture catheters are first passed through the aorta to the right atrium, and then the first and second puncture catheters are used to puncture the atrial septum respectively, so that the distal ends of the first and second puncture catheters reach the left atrium, leaving the first and second guide wires, the first puncture tube of the first puncture catheter is removed, the second puncture tube of the second puncture catheter is removed, the first sheath tube is inserted along the first guide wire, so that the distal end of the first sheath tube reaches the left atrium, the second sheath tube is inserted along the second guide wire, so that the distal end of the second sheath tube reaches the left atrium, the second guide wire is removed, the occluding component is compressed and assembled into the second sheath tube, and the occluding component is pushed to the distal end of the second sheath tube by the push rod; the first sheath tube is controlled so that the distal end of the first sheath tube enters the left atrial appendage, and the occluding component is pushed to the distal end of the second sheath tube by the push rod. A sheath tube pumps adhesive material into the left atrial appendage so that the bottom of the left atrial appendage is filled with the adhesive material, the first sheath tube is removed, and the distal end of the second sheath tube is controlled to be in the left atrial appendage. The plugging piece is pushed out from the distal end of the second sheath tube by a push rod, and the plug connector of the plugging piece is first extended from the distal end of the second sheath tube, and the plug connector is inserted into the adhesive material. After the blocking block extends out of the second sheath tube, the blocking block is no longer restricted by the second sheath tube. The blocking block switches to a natural state to block the entire left atrial appendage. The adhesive material solidifies after a certain period of time to form an adhesive layer, which is bonded to the inner wall of the left atrial appendage. At the same time, the plug connector is inserted into the adhesive layer, and the adhesive layer will lock the plug connector. The plug connector is connected to the blocking block, so that the blocking block is relatively fixed in the left atrial appendage, thereby achieving blocking of the left atrial appendage.

[0022] After the left atrial appendage occlusion surgery is performed by the present invention, the left atrial appendage is almost filled with the adhesive layer and the occluding member, so that no cavity structure is formed in the left atrial appendage. Moreover, the bonding force between the adhesive layer and the left atrial appendage is an adhesive force, which almost does not generate a compressive force on the left atrial appendage, so that the adhesive layer does not have the risk of falling off, thereby ensuring the occluding effect on the left atrial appendage.

[0023] Moreover, the sealing parts and bonding materials will not release Ni ions, thus avoiding allergic reactions to the human body. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] The above and other objects, features and advantages of the present invention will become more apparent through the following description of the embodiments of the present invention with reference to the accompanying drawings, in which:

[0025] Figure 1 This is a schematic diagram of the first sheath entering the left atrial appendage;

[0026] Figure 2 This is a schematic diagram of the second sheath entering the left atrial appendage;

[0027] Figure 3 It is a structural schematic diagram of the plugging member;

[0028] Figure 4 It is a cross-sectional view of an embodiment of a plug connector.

[0029] In the figure: 1, first sheath tube; 2, adhesive material; 3, second sheath tube; 4, adhesive layer; 5, plugging member;

[0030] 51. Plug connector; 52. Blocking block; 53. Center rod; 54. Stop rod; 511. Small diameter section; 512. Large diameter section. DETAILED DESCRIPTION

[0031] The present invention is described below based on embodiments, but the present invention is not limited to these embodiments. In the following detailed description of the present invention, some specific details are described in detail. In order to avoid confusing the essence of the present invention, known methods, processes, procedures, and components are not described in detail.

[0032] In addition, persons of ordinary skill in the art will appreciate that the drawings provided herein are for illustration purposes and are not necessarily drawn to scale.

[0033] Unless the context clearly requires otherwise, throughout the specification and claims, the words "include", "comprising" and similar words should be interpreted in an inclusive sense rather than an exclusive or exhaustive sense; that is, in the sense of "including but not limited to".

[0034] In the description of the present invention, it should be understood that the terms "first", "second", etc. are only used for descriptive purposes and cannot be understood as indicating or implying relative importance. In addition, in the description of the present invention, unless otherwise specified, "plurality" means two or more.

[0035] Taking interventional surgery as an example, the end closer to the ventricle is the "distal end" and the end closer to the doctor (operator) is the "proximal end".

[0036] See also Figure 1-Figure 4The present invention provides a left atrial appendage occluding assembly for occluding the left atrial appendage, comprising a first sheath tube 1, a second sheath tube 3 and an occluding member 5, wherein the first sheath tube 1 is used to transport an adhesive material 2 to the bottom of the left atrial appendage to form an adhesive layer 4; the occluding member 5 is arranged in the second sheath tube 3, and the occluding member 5 is pushed out from the distal end of the second sheath tube 3 and released into the left atrial appendage by a push rod, so that a part of the occluding member 5 is inserted into the adhesive material 2 at the bottom of the left atrial appendage, and when the adhesive material 2 is cured to form the adhesive layer 4, the adhesive layer 4 can lock the occluding member 5;

[0037] The blocking member 5 comprises a plug connector 51 and a compressible blocking block 52, wherein the blocking block 52 is connected to the plug connector 51 and can be compressed. In a natural state, the blocking block 52 is columnar, and the radial dimension of the blocking block 52 is substantially consistent with the internal dimension of the left atrial appendage (the radial dimension of the blocking block 52 may be larger than the internal dimension of the left atrial appendage, for example, 1.1 times the internal dimension of the left atrial appendage. Of course, considering the compressible characteristic of the blocking block 52, in a natural state, the radial dimension of the blocking block 52 may be up to 3 times the internal dimension of the left atrial appendage); the plug connector 51 is coaxially arranged with the blocking block 52, the plug connector 51 is connected to the blocking block 52, and the plug connector 51 is used to be inserted into the adhesive material 2, and the blocking member 5 has a compressed state and a natural state;

[0038] In the compressed state, the blocking block 52 is radially compressed so that the radial dimension of the blocking block 52 is consistent with the inner diameter of the second sheath tube 3, so that the blocking member 5 can be transmitted through the second sheath tube 3;

[0039] In the natural state, the blocking block 52 is expanded into a columnar shape to block the left atrial appendage.

[0040] In the present invention, the adhesive material 2 is in a paste form. After being injected into the left atrial appendage, after a certain period of time (for example, 5-10 minutes), the adhesive material 2 will solidify to form an adhesive layer 4, and the adhesive layer 4 will adhere to the contact point with the left atrial appendage, thereby being fixed in the left atrial appendage.

[0041] When performing left atrial appendage occlusion surgery, two puncture catheters are inserted along the aorta in advance (basically the same as the existing left atrial appendage surgery process, except that the existing left atrial appendage surgery usually has only one puncture catheter). The puncture catheter includes a puncture catheter and a guide wire. The guide wire is inserted into the puncture catheter. For the convenience of description, the two puncture catheters are respectively the first puncture catheter and the second puncture catheter. The first and second puncture catheters pass through the aorta to the right atrium, and then the first and second puncture catheters are used to puncture the atrial septum respectively, so that the distal ends of the first and second puncture catheters reach the left atrium, and the first puncture catheter (the puncture catheter of the first puncture catheter) and the second puncture catheter (the puncture catheter of the second puncture catheter) are removed, leaving the first guide wire (the guide wire of the first puncture catheter) and the second guide wire (the guide wire of the second puncture catheter). The distal ends of the first guide wire and the second guide wire are both located in the left atrium, the first sheath tube 1 is inserted along the first guide wire, so that the distal end of the first sheath tube 1 reaches the left atrium, the second sheath tube 3 is inserted along the second guide wire, so that the distal end of the second sheath tube 3 reaches the left atrium, the second guide wire is removed (the first guide wire can also be removed), the blocking member 5 is compressed and assembled into the second sheath tube 3 (proximal end), and the blocking member 5 is pushed to the distal end of the second sheath tube 3 by the push rod; the first sheath tube 1 is controlled so that the distal end of the first sheath tube 1 enters the left atrial appendage, and the adhesive material 2 is pumped into the left atrial appendage through the first sheath tube 1, so that the bottom of the left atrial appendage (for example, along the depth direction of the left atrial appendage, 1 / 3 of the deep left atrial appendage is filled with adhesive material 2) is filled with adhesive material 2; the following actions are completed before the adhesive material 2 is cured:

[0042] The first sheath tube 1 is removed (the distal end of the first sheath tube 1 is separated from the left atrial appendage) to make room for the internal space of the left atrial appendage: the distal end of the second sheath tube 3 is controlled to extend into the left atrial appendage (the plug connector 51 is closer to the port at the distal end of the second sheath tube 3 than the blocking block 52), the blocking piece 5 is supported by the push rod, and the second sheath tube 3 is pulled toward the proximal side, so that the blocking piece 5 is exposed from the distal end of the second sheath tube 3, and the plug connector 51 is exposed first, and the plug connector 51 is controlled to be inserted into the adhesive material 2. After the blocking block 52 extends out of the second sheath tube 3, the blocking block 52 is no longer Restricted by the second sheath 3, the blocking block 52 switches to a natural state to block the entire left atrial appendage (the blocking block 52 actively forms a plug after absorbing blood, forming a solid blocking area), and the adhesive material 2 solidifies after a certain period of time to form an adhesive layer 4, which is bonded to the inner wall of the left atrial appendage. At the same time, the plug connector 51 is inserted into the adhesive layer 4, and the adhesive layer 4 will lock the plug connector 51, and the plug connector 51 is connected to the blocking block 52, so that the blocking block 52 is relatively fixed in the left atrial appendage, thereby achieving the blocking of the left atrial appendage.

[0043] In the above process, the internal space of the left atrial appendage is basically completely filled with the adhesive layer 4 and the blocking member 5, so that no cavity structure is formed in the left atrial appendage. Moreover, the bonding force between the adhesive layer 4 and the left atrial appendage is an adhesive force, which almost does not generate a compressive force on the left atrial appendage, so that the adhesive layer 4 does not have the risk of falling off, thereby ensuring the blocking effect on the left atrial appendage.

[0044] The length of the plug connector 51 is preferably 1 / 2 of the thickness of the adhesive layer 4 , and it is completely inserted into the adhesive layer 4 so that the distal end of the blocking block 52 is substantially in contact with the interface of the adhesive layer 4 .

[0045] Preferably, the diameter of the plug connector 51 is slightly (the diameter of the plug connector 51 is 90%-99% of the inner diameter of the second sheath tube 3 ) smaller than the inner diameter of the second sheath tube 3 ;

[0046] The plug connector 51 cannot be compressed, and the diameter of the plug connector 51 is slightly smaller than the inner diameter of the second sheath tube 3 , so that the plug connector 51 can move inside the second sheath tube 3 .

[0047] The blocking member 5 also includes a skeleton, which includes a center rod 53 connected to each other and a stopper connected to one end of the center rod 53. The center rod 53 is inserted at the center of the blocking block 52. The center rod 53 is coaxially arranged with the blocking block 52. The other end of the center rod 53 is connected to the plug connector 51. The stopper abuts against one end of the blocking block 52 away from the plug connector 51 to limit the position of the blocking block 52.

[0048] The skeleton is connected to the plug connector 51, and the stopper is located on the proximal side. The stopper can block the blocking block 52 from the proximal side. After the blocking member 5 is set in the left atrial appendage, the proximal side of the blocking member 5 corresponds to the mouth of the left atrial appendage, and the blocking member 5 is located at the mouth to prevent the blocking block 52 from detaching from the skeleton, thereby ensuring the blocking effect on the left atrial appendage.

[0049] Preferably, the skeleton and the plug connector 51 are integrally formed, and the skeleton and the plug connector 51 are obtained by 3D printing using PDO material (polydioxanone), and the plug connector 51 is hollow.

[0050] The plug connector 51 is hollow. After the plug connector 51 is inserted into the adhesive material 2, the adhesive material 2 can enter the plug connector 51 from the hollow hole. After the adhesive material 2 is cured, the adhesion of the adhesive material 2 to the plug connector 51 can be improved, preventing the plug connector 51 from falling off the adhesive layer 4, thereby improving the effect of the operation.

[0051] Of course, the frame and the plug connector 51 can also be made of other materials, such as metal materials such as platinum and nickel-titanium alloy; degradable polymer materials such as polyurethane, PLA (polylactic acid), PCL (polycaprolactone), etc.

[0052] Preferably, the radial dimension of the stopper is consistent with the radial dimension of the plug connector 51;

[0053] The radial dimension of the stopper is consistent with the radial dimension of the plug connector 51, so that the stopper can be smoothly transmitted through the second sheath tube 3.

[0054] The stopper comprises a plurality of blocking rods 54, each of which has a first end and a second end. The first ends of all the blocking rods 54 are connected to each other at the same point, which is the center point. The axes of the plurality of blocking rods 54 are located in the same plane, and the plurality of blocking rods 54 are evenly arranged around the center point. One end of the center rod 53 is connected to the center point.

[0055] The diameter of the central rod 53 is smaller than the diameter of the plug connector 51 , and the side of the blocking block 52 close to the plug connector 51 abuts against the end of the plug connector 51 .

[0056] The distal end of the blocking block 52 abuts against the plug connector 51, and the proximal end of the blocking block 52 abuts against the stopper, so that the blocking block 52 will not slide on the center rod 53. Therefore, after being implanted into the left atrial appendage, the stopper will not move accidentally, thereby improving the surgical effect.

[0057] Preferably, see Figure 4 The plug connector 51 includes a small diameter section 511 and a large diameter section 512 connected to each other, one end of the small diameter section 511 away from the large diameter section 512 is connected to the other end of the center rod 53, and the ratio of the length of the small diameter section 511 to the large diameter section 512 is (5-10):1.

[0058] The diameter of the large diameter section 512 is greater than that of the small diameter section 511 , and a step structure is formed between the large diameter section 512 and the small diameter section 511 , which further enhances the locking effect of the adhesive layer 4 on the plug connector 51 .

[0059] Of course, in other embodiments, the plug connector 51 may include multiple large diameter sections and small diameter sections. In the axial direction, the large diameter sections and the small diameter sections are staggered, which can also enhance the locking effect of the adhesive layer 4 on the plug connector 51.

[0060] Preferably, the blocking block 52 is made of biodegradable polyurethane foam.

[0061] Preferably, the adhesive material 2 includes an adhesive and a developing material, the adhesive is one or more of fibrin glue, polydopamine-type polyurethane adhesive, amino-containing polyester polyurethane adhesive, poly (N-isopropylacrylamide) adhesive; the developing material is one or more of tantalum nanoparticles, bismuth oxide, bismuth subcarbonate and barium sulfate;

[0062] The mass ratio of the developing material to the binder is (5-10):100.

[0063] The developed biodegradable polyurethane foam can be realized by using the materials disclosed in patent CN202411132779.2, which is the prior art and will not be described in detail here.

[0064] The adhesive material 2 includes a developing material. When the adhesive material 2 is set in the left atrial appendage, the filling process of the adhesive material 2 can be directly developed, which facilitates the control of the adhesive material 2 filling the predetermined position, ensures the surgical effect, and improves the safety of the surgery.

[0065] When manufacturing the blocking member 5 , the mutually connected skeleton and the plug connector 51 can be first printed, and then a developing biodegradable polyurethane foam is arranged on the central rod 53 for foaming, and finally the blocking member 5 is obtained by trimming.

[0066] In addition, under natural conditions, the diameter of the blocking block 52 can be 1.5-3 times the maximum inner diameter of the left atrial appendage, so that after the blocking block 52 is located in the left atrial appendage, the blocking block 52 can fully fit with the inner wall of the left atrial appendage, which on the one hand improves the blocking effect, and on the other hand, increases the friction with the left atrial appendage, preventing the blocking block 52 from falling off from the left atrial appendage and improving safety.

[0067] Preferably, it also includes a first puncture catheter and a second puncture catheter, which are used to pass through the artery and puncture the atrial septum of the heart, and leave a first guide wire of the first puncture catheter and a second guide wire of the second puncture catheter, so as to facilitate guiding the first sheath tube 1 along the first guide wire so that the distal end of the first sheath tube 1 reaches the left atrium, and guiding the second sheath tube 3 along the second guide wire so that the distal end of the second sheath tube 3 reaches the left atrium.

[0068] The first puncture catheter and the second puncture catheter have been introduced in the previous text and will not be described again here.

[0069] It should be understood that the above-mentioned embodiments are merely illustrative and not restrictive. Without departing from the basic principles of the present invention, various obvious or equivalent modifications or substitutions that can be made by those skilled in the art to the above-mentioned details will all be included in the scope of the claims of the present invention.

Claims

1. A left atrial appendage occlusion assembly, characterized in that: Used to block the left atrial appendage, comprising a first sheath tube, a second sheath tube and a blocking piece, wherein the first sheath tube and the second sheath tube are independent of each other, and the first sheath tube is used to transport an adhesive material to the bottom of the left atrial appendage to form an adhesive layer; the blocking piece is arranged in the second sheath tube, and the blocking piece is pushed out from the distal end of the second sheath tube and released into the left atrial appendage by a push rod, so that part of the blocking piece is inserted into the adhesive material at the bottom of the left atrial appendage, and when the adhesive material is cured to form an adhesive layer, the adhesive layer can lock the blocking piece; The plugging member comprises a plug connector and a compressible plugging block, the plug connector is connected to the plug connector, the plugging block can be compressed, and in a natural state, the plugging block is columnar, and the radial dimension of the plugging block is substantially consistent with the internal dimension of the left atrial appendage; the plug connector is coaxially arranged with the plugging block, the plug connector is connected to the plugging block, the plug connector is used to be inserted into the adhesive material, and the plugging member has a compressed state and a natural state; In the compressed state, the blocking block is radially compressed so that the radial dimension of the blocking block is consistent with the inner diameter of the second sheath tube, so that the blocking piece can be transmitted through the second sheath tube; In the natural state, the blocking block is expanded into a columnar shape to block the left atrial appendage; The diameter of the plug connector is slightly smaller than the inner diameter of the second sheath tube; The blocking piece also includes a skeleton, which includes a central rod connected to each other and a stopper connected to one end of the central rod, the central rod is plugged into the center of the blocking block, the central rod and the blocking block are coaxially arranged, the other end of the central rod is connected to the plug connector, and the stopper abuts against one end of the blocking block away from the plug connector to limit the position of the blocking block; The skeleton and the plug connector are integrally formed, and the skeleton and the plug connector are obtained by 3D printing using PDO material, and the plug connector is hollow.

2. The left atrial appendage occlusion assembly according to claim 1, characterized in that: The radial dimension of the stopper is consistent with the radial dimension of the plug connector; The stopper comprises a plurality of stop rods, each of the stop rods having a first end and a second end, the first ends of all the stop rods being connected to one another at the same point, which is a center point, the axes of the plurality of stop rods being located in the same plane, and the plurality of stop rods being evenly arranged around the center point; one end of the center rod being connected to the center point; The diameter of the central rod is smaller than the diameter of the plug connector, and the side of the blocking block close to the plug connector abuts against the end of the plug connector.

3. The left atrial appendage occlusion assembly according to claim 1, characterized in that: The plug connector includes a small diameter section and a large diameter section connected to each other, one end of the small diameter section away from the large diameter section is connected to the other end of the center rod, and the ratio of the length of the small diameter section to the large diameter section is (5-10):

1.

4. The left atrial appendage occlusion assembly according to claim 1, characterized in that: The blocking block is made of developed biodegradable polyurethane foam.

5. The left atrial appendage occlusion assembly according to claim 1, characterized in that: The adhesive material comprises an adhesive and a developing material, wherein the adhesive is one or more of fibrin glue, polydopamine-type polyurethane adhesive, amino-containing polyester-type polyurethane adhesive, and poly (N-isopropylacrylamide) adhesive; the developing material is one or more of tantalum nanoparticles, bismuth oxide, bismuth subcarbonate, and barium sulfate; The mass ratio of the developing material to the binder is (5-10):

100.

6. The left atrial appendage occlusion assembly according to any one of claims 1 to 5, characterized in that: It also includes a first puncture catheter and a second puncture catheter, which are used to pass through the artery and puncture the atrial septum of the heart, and leave a first guide wire of the first puncture catheter and a second guide wire of the second puncture catheter, so as to facilitate guiding the first sheath tube along the first guide wire so that the distal end of the first sheath tube reaches the left atrium, and guiding the second sheath tube along the second guide wire so that the distal end of the second sheath tube reaches the left atrium.

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