Traditional Chinese medicine composition for treating plateau chronic pharyngitis

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating plateau chronic pharyngitis, which comprises the following raw materials in parts by weight: 2-20 parts of ginseng, 2-30 parts of astragalus membranaceus, 1-10 parts of dendrobe, 1-15 parts of medlar, 1-30 parts of bighead atractylodes rhizome, 1-18 parts of thunberg fritillary bulb, 2-30 parts of momordica grosvenori, 1-15 parts of pericarpium citri reticulatae, 1-15 parts of mint, 1-15 parts of honeysuckle and 1-20 parts of chrysanthemum. The traditional Chinese medicine composition for treating plateau chronic pharyngitis has the effects of tonifying qi and relieving sore-throat, is refreshing and pleasant in taste, can mildly and effectively act on the throat part, relieves dry itching, pain, chronic cough, hoarseness and the like, achieves the goal of integrating treatment, prevention and health care, and embodies the idea of treating diseases by traditional Chinese medicines.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating chronic pharyngitis at high altitude. Background Art

[0002] Chronic pharyngitis is a chronic inflammation of the pharyngeal mucosa, submucosal and lymphatic tissues. Diffuse pharyngitis is often a part of chronic inflammation of the upper respiratory tract; localized pharyngitis is mostly inflammation of the pharyngeal lymphatic tissues. This disease is common in clinical practice, has a long course, and symptoms are prone to recurrence.

[0003] Chronic pharyngitis is more common in adults, but can also occur in children. Systemic symptoms are not obvious, and local symptoms are the main symptoms. The symptoms of various types of chronic pharyngitis are roughly similar and varied, such as discomfort in the throat, foreign body sensation, difficulty in coughing up pharyngeal secretions, itching, burning, dryness or irritation in the throat, and slight pain. Because the posterior pharyngeal wall usually has thicker secretions adhering to it due to chronic inflammation of the pharynx, and because of lesions in the nose, sinuses, and nasopharynx that cause mouth breathing at night, irritating coughs and nausea often occur in the morning. The foreign body sensation in the throat can manifest as frequent swallowing. People with less pharyngeal secretions and those who are not easy to cough up often have habitual dry coughs and clearing the throat to expectorate. If you cough or clear your throat hard, it can cause bleeding of the pharyngeal mucosa, resulting in blood in the secretions.

[0004] The plateau area has environmental characteristics such as low oxygen, high cold, low pressure, high radiation, strong wind and sand, and dry air. The respiratory tract of soldiers stationed in the plateau is exposed to the external environment for a long time, and they are prone to diseases such as chronic pharyngitis, chronic tonsillitis, and chronic cough. These diseases often have a long course and are easily affected by various factors, resulting in repeated attacks and difficulty in healing, which can easily affect the quality of life of patients.

[0005] Western medicine lacks effective treatment methods for this type of chronic disease, and traditional Chinese medicine lacks effective medicine. This type of disease belongs to the category of "chronic throat paralysis" in traditional Chinese medicine. The disease is located in the throat, and the throat is the gateway to the lungs. "The upper part of the body is like a feather, it cannot rise without clearness", so most of the traditional Chinese medicines used to treat this type of disease are light and clear. The traditional method of decocting decoctions can easily cause the pungent taste to evaporate quickly, thus losing the efficacy; and the traditional decoction method is time-consuming and laborious, and patients often find it difficult to persist, and it is difficult to obtain good results with short-term medication. Therefore, it is urgent to find a traditional Chinese medicine dosage form that is easy to take and can ensure the effectiveness of the drug, which is of great significance for the prevention and treatment of this disease. Summary of the invention

[0006] In order to solve the above technical problems, an embodiment of the present invention provides a Chinese medicine composition for treating chronic pharyngitis at high altitude.

[0007] To achieve the above object, the embodiments of the present invention adopt the following technical solutions:

[0008] On the one hand, the present invention provides a traditional Chinese medicine composition for treating chronic pharyngitis at high altitude, comprising the following raw materials, by weight: 2-20 parts of ginseng, 2-30 parts of astragalus, 1-10 parts of dendrobium, 1-15 parts of wolfberry, 1-30 parts of atractylodes, 1-18 parts of thunbergii, 2-30 parts of momordica grosvenori, 1-15 parts of tangerine peel, 1-15 parts of mint, 1-15 parts of honeysuckle and 1-20 parts of chrysanthemum.

[0009] In some embodiments, the following raw materials are included, by weight: 2-15 parts of ginseng, 2-20 parts of astragalus, 1-8 parts of dendrobium, 1-10 parts of wolfberry, 1-25 parts of atractylodes, 1-15 parts of thunbergii, 2-25 parts of momordica grosvenori, 1-12 parts of tangerine peel, 1-13 parts of mint, 1-10 parts of honeysuckle and 1-15 parts of chrysanthemum.

[0010] In some embodiments, the following raw materials are included, by weight: 2-10 parts of ginseng, 2-15 parts of astragalus, 1-5 parts of dendrobium, 1-8 parts of wolfberry, 1-20 parts of atractylodes, 1-12 parts of thunbergii, 2-20 parts of momordica grosvenori, 1-10 parts of tangerine peel, 1-10 parts of mint, 1-8 parts of honeysuckle and 1-10 parts of chrysanthemum.

[0011] In some embodiments, the following raw materials are included, by weight: 2-5 parts of ginseng, 2-10 parts of astragalus, 1-3 parts of dendrobium, 1-5 parts of wolfberry, 1-10 parts of atractylodes, 1-5 parts of thunbergii, 2-10 parts of momordica grosvenori, 1-5 parts of tangerine peel, 1-5 parts of mint, 1-5 parts of honeysuckle and 1-5 parts of chrysanthemum.

[0012] In some embodiments, the following raw materials are included, by weight: 2 parts of ginseng, 2 parts of astragalus, 1 part of dendrobium, 1 part of wolfberry, 1 part of atractylodes, 1 part of thunbergii, 2 parts of momordica, 1 part of tangerine peel, 1 part of mint, 1 part of honeysuckle and 1 part of chrysanthemum.

[0013] Chinese herbal tea substitute is a prescription made with appropriate Chinese herbal ingredients selected under the guidance of the theory of TCM's syndrome differentiation and treatment. When used, it is directly brewed with boiling water as tea. There is no strict time limit and it can be drunk frequently to achieve the effects of preventing and treating diseases, maintaining health and conditioning. It is the main preventive and treatment method for mild and chronic diseases, as well as an important means of daily health care and conditioning.

[0014] The Qi-replenishing and Throat-relief Health Tea is a tea substitute with the function of replenishing qi and relieving throat, which is formulated under the guidance of the theory of Chinese medicine, method, prescription and medicine, and based on the combination of syndrome differentiation and disease differentiation. The formula contains ginseng, astragalus, dendrobium, wolfberry, white atractylodes, Zhejiang Fritillaria, monk fruit, tangerine peel, mint, honeysuckle and chrysanthemum.

[0015] Ginseng: sweet, slightly bitter, slightly warm, and enters the spleen, lung, heart, and kidney meridians.

[0016] Astragalus: sweet in taste, slightly warm in nature, enters the lung and spleen meridians.

[0017] Dendrobium: sweet in taste, slightly cold in nature, enters the stomach and kidney meridians.

[0018] Lycium barbarum: sweet and neutral in nature, enters the liver and kidney meridians.

[0019] Atractylodes macrocephala: bitter, sweet and warm; enters the spleen and stomach meridians.

[0020] Fritillaria thunbergii: bitter, cold in nature. Enters the lung and heart meridians.

[0021] Luo Han Guo: sweet and cool in nature, enters the lung and large intestine meridians.

[0022] Tangerine peel: bitter, pungent and warm in nature, and enters the lung and spleen meridians.

[0023] Peppermint: spicy, cool, enters the lung and liver meridians.

[0024] Honeysuckle: sweet and cold in nature, enters the lung and stomach meridians.

[0025] Chrysanthemum: spicy, sweet, bitter, slightly cold. Enter the lung and liver meridians.

[0026] The ginseng in the prescription has the effects of greatly replenishing vital energy, restoring pulse and consolidating deficiency, replenishing spleen and lung, promoting body fluid and nourishing blood, calming the mind and improving intelligence. Ginseng is the main medicine, and astragalus replenishes qi, has the effects of enhancing immunity, antibacterial, antiviral, reducing inflammatory response, and reducing oxidative stress response. In addition, astragalus can also reduce high-altitude erythrocytosis induced by plateau hypoxia and improve oxygen carrying capacity, which is the main medicine. Atractylodes macrocephala replenishes qi, dendrobium, and wolfberry nourish yin, and are used together with astragalus to replenish qi and nourish yin, which are the ministerial medicines. Fritillaria thunbergii, momordica grosvenori, tangerine peel, mint, honeysuckle, and chrysanthemum clear the lungs, resolve phlegm and relieve cough, detoxify, disperse knots and relieve sore throat, which are the adjuvants. The whole prescription is used together to achieve the effects of replenishing qi and relieving sore throat, anti-inflammatory and antiviral, and enhancing respiratory immunity. It can be widely used to prevent and treat chronic pharyngitis, chronic tonsillitis, chronic cough, and relieve vocal cord nodules, incomplete vocal cord closure, hoarseness caused by tobacco, alcohol, colds, and excessive use of the voice. Due to the influence of the plateau environment, adding an appropriate amount of ginseng to prevent and treat plateau throat diseases can greatly replenish vitality, nourish the spleen and lungs, promote the production of body fluids and nourish blood. It has anti-hypoxia, anti-fatigue, anti-inflammatory, anti-oxidation and neuroprotective effects.

[0027] This Chinese medicine combination for plateau chronic pharyngitis can replenish qi and relieve sore throat, has a refreshing and pleasant taste, can gently and effectively act on the throat area, relieve dryness and itching, pain, chronic cough, hoarseness, etc., achieves the goal of integrating treatment with preventive health care, and embodies the concept of Chinese medicine of preventing disease before it occurs. DETAILED DESCRIPTION

[0028] The technical solutions in some embodiments of the present disclosure are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present disclosure, not all of the embodiments. Based on the embodiments provided by the present disclosure, all other embodiments obtained by ordinary technicians in this field belong to the scope of protection of the present disclosure.

[0029] Example 1

[0030] Add 2g of ginseng, 2g of astragalus, 2g of dendrobium, 1g of wolfberry, 3g of atractylodes, 2g of thunbergii, 2g of momordica, 1g of tangerine peel, 1g of mint, 1g of honeysuckle and 1g of chrysanthemum into boiling water and soak for 7 minutes. It is then ready to drink.

[0031] Example 2

[0032] Add 2g of ginseng, 5g of astragalus, 1g of dendrobium, 2g of wolfberry, 1g of atractylodes, 2g of thunbergia, 2g of monk fruit, 1g of tangerine peel, 1g of mint, 2g of honeysuckle and 3g of chrysanthemum into boiling water and soak for 8 minutes. It is then ready to drink.

[0033] Example 3

[0034] Add 20g of ginseng, 30g of astragalus, 10g of dendrobium, 15g of wolfberry, 30g of atractylodes, 18g of thunbergia, 30g of momordica, 15g of tangerine peel, 15g of mint, 15g of honeysuckle and 20g of chrysanthemum into boiling water and soak for 12 minutes. It is then ready to drink.

[0035] Example 4

[0036] Add 15g of ginseng, 20g of astragalus, 10g of dendrobium, 15g of wolfberry, 20g of atractylodes, 15g of thunbergii, 30g of momordica grosvenori, 15g of tangerine peel, 15g of mint, 15g of honeysuckle and 20g of chrysanthemum into boiling water and soak for 16 minutes. It is then ready to drink.

[0037] Example 5

[0038] Add 5g of ginseng, 4g of astragalus, 6g of dendrobium, 7g of wolfberry, 4g of atractylodes, 4g of thunbergii, 3g of momordica grosvenori, 5g of tangerine peel, 3g of mint, 2g of honeysuckle and 3g of chrysanthemum into boiling water and soak for 15 minutes. It is then ready to drink.

[0039] Example 6

[0040] Add 10g of ginseng, 15g of astragalus, 8g of dendrobium, 10g of wolfberry, 15g of atractylodes, 9g of thunbergia, 15g of momordica, 8g of tangerine peel, 10g of mint, 10g of honeysuckle and 10g of chrysanthemum into boiling water and soak for 18 minutes. It is then ready to drink.

[0041] Example 7

[0042] Add 18g of ginseng, 25g of astragalus, 8g of dendrobium, 13g of wolfberry, 25g of atractylodes, 15g of thunbergii, 27g of momordica grosvenori, 13g of tangerine peel, 14g of mint, 10g of honeysuckle and 16g of chrysanthemum into boiling water and soak for 20 minutes before drinking.

[0043] Example 8

[0044] Add 8g of ginseng, 12g of astragalus, 5g of dendrobium, 7g of wolfberry, 8g of atractylodes, 5g of thunbergii, 14g of momordica grosvenori, 6g of tangerine peel, 6g of mint, 5g of honeysuckle and 6g of chrysanthemum into boiling water and soak for 20 minutes. It is then ready to drink.

[0045] Example 9

[0046] Add 12g of ginseng, 22g of astragalus, 7g of dendrobium, 10g of wolfberry, 21g of atractylodes, 13g of thunbergii, 21g of momordica grosvenori, 11g of tangerine peel, 10g of mint, 9g of honeysuckle and 13g of chrysanthemum into boiling water and soak for 17 minutes before drinking.

[0047] Example 10

[0048] Add 3g of ginseng, 3g of astragalus, 2g of dendrobium, 2g of wolfberry, 2g of atractylodes, 2g of thunbergii, 3g of momordica grosvenori, 2g of tangerine peel, 2g of mint, 2g of honeysuckle and 2g of chrysanthemum into boiling water and soak for 11 minutes. It is then ready to drink.

[0049] Embodiment 11

[0050] Add 18g of ginseng, 28g of astragalus, 8g of dendrobium, 13g of wolfberry, 28g of atractylodes, 16g of thunbergii, 28g of momordica, 13g of tangerine peel, 13g of mint, 13g of honeysuckle and 18g of chrysanthemum into boiling water and soak for 18 minutes before drinking.

[0051] Example 12

[0052] Add 15g of ginseng, 25g of astragalus, 5g of dendrobium, 10g of wolfberry, 25g of atractylodes, 13g of thunbergii, 25g of momordica, 10g of tangerine peel, 10g of mint, 10g of honeysuckle and 15g of chrysanthemum into boiling water and soak for 18 minutes. It is then ready to drink.

[0053] Embodiment 13

[0054] Add 13g of ginseng, 23g of astragalus, 5g of dendrobium, 10g of wolfberry, 20g of atractylodes, 8g of thunbergii, 22g of momordica grosvenori, 8g of tangerine peel, 10g of mint, 12g of honeysuckle and 13g of chrysanthemum into boiling water and soak for 17 minutes before drinking.

[0055] Embodiment 14

[0056] Add 10g of ginseng, 20g of astragalus, 6g of dendrobium, 5g of wolfberry, 20g of atractylodes, 9g of thunbergia, 20g of momordica, 5g of tangerine peel, 9g of mint, 8g of honeysuckle and 10g of chrysanthemum into boiling water and soak for 16 minutes. It is then ready to drink.

[0057] Embodiment 15

[0058] Add 2g of ginseng, 2g of astragalus, 1g of dendrobium, 1g of wolfberry, 1g of atractylodes, 1g of thunbergii, 1g of monk fruit, 2g of tangerine peel, 1g of mint, 1g of honeysuckle and 1g of chrysanthemum into boiling water and soak for 10 minutes. It is then ready to drink.

[0059] Example 16

[0060] Add 4g of ginseng, 8g of astragalus, 4g of dendrobium, 4g of wolfberry, 4g of atractylodes, 4g of thunbergii, 4g of monk fruit, 8g of tangerine peel, 4g of mint, 4g of honeysuckle and 2g of chrysanthemum into boiling water and soak for 12 minutes. It is then ready to drink.

[0061] Embodiment 17

[0062] Add 8g of ginseng, 16g of astragalus, 8g of dendrobium, 8g of wolfberry, 8g of atractylodes, 8g of thunbergii, 8g of monk fruit, 16g of tangerine peel, 8g of mint, 8g of honeysuckle and 4g of chrysanthemum into boiling water and soak for 16 minutes. It is then ready to drink.

[0063] Embodiment 18

[0064] Add 2g of ginseng, 2g of astragalus, 1g of dendrobium, 1g of wolfberry, 1g of atractylodes, 1g of thunbergii, 1g of monkshood, 2g of tangerine peel, 1g of mint, 1g of honeysuckle and 1g of chrysanthemum into boiling water and soak for 6 minutes. It is then ready to drink.

[0065] The clinical efficacy and safety analysis of the composition of the present invention in treating patients with chronic pharyngitis at high altitude are studied.

[0066] 1. Research Methods

[0067] 1.1 Cases and groups

[0068] According to the relevant diagnostic criteria, inclusion criteria, and exclusion criteria, 60 patients with high-altitude chronic pharyngitis diagnosed from March 1, 2024 to September 30, 2024 were included, aged 18-60 years old, regardless of gender. According to the patient's visit time, they were numbered 1-60 and randomly divided into a treatment group (n=30) and a waiting treatment group (n=30). The treatment group was given Example 15 to obtain a Chinese medicine composition (tentative trade name: Qi-replenishing and throat-relief health tea) once a dose, twice a day, for 14 consecutive days, and the brewing method was the same as before. Waiting treatment group: After 14 days of enrollment, the Chinese medicine composition (tentative trade name: Qi-replenishing and throat-relief health tea) was given in Example 15 once a dose, twice a day, for 14 consecutive days, and the brewing method was the same as before.

[0069] The treatment group recorded changes in symptoms and signs after drinking for 7 and 14 days.

[0070] 1.2 Diagnostic criteria

[0071] 1.2.1 Western medicine diagnostic criteria

[0072] The diagnostic criteria for chronic pharyngitis were formulated in accordance with the Otorhinolaryngology Head and Neck Surgery:

[0073] (1) Past medical history: Recurrent attacks of acute pharyngitis due to environmental pollution, occupational exposure, addiction to tobacco and alcohol, and chronic inflammation of the upper respiratory tract.

[0074] (2) Clinical manifestations: Itchy throat, dry throat, sore throat, foreign body sensation in the throat, burning sensation in the throat, or other discomfort in the throat, or irritating dry cough, or even nausea.

[0075] (3) Pharyngeal examination: Chronic congestion of the pharyngeal mucosa, dark red in color, or dendritic congestion; hyperplasia of lymphoid follicles on the posterior pharyngeal wall, or redness and swelling of the lateral pharyngeal cords; hypertrophy and hyperplasia of the pharyngeal mucosa, or atrophy and dryness of the mucosa; thickening of the uvula, drooping like an earthworm.

[0076] After excluding other lesions, a diagnosis can be made if one of the above items is met.

[0077] 1.2.1 TCM diagnostic criteria

[0078] With reference to the "Traditional Chinese Medicine Industry Standards of the People's Republic of China - Diagnosis and Efficacy Standards for TCM Otolaryngology Diseases" and "Guidelines for Diagnosis and Treatment of Common Diseases in TCM Otolaryngology of the Chinese Association of Traditional Chinese Medicine" issued in 2012, combined with the characteristics of chronic pharyngitis at high altitude, the following is formulated:

[0079] (1) Local symptoms: dry throat, itchy throat, dry mouth and no desire to drink, or drinking less water, sore throat, foreign body sensation in the throat, dry cough, or little sputum, sticky sputum that is difficult to cough up, symptoms that worsen after talking too much or in the afternoon or evening;

[0080] (2) Red tongue with little or thin white coating, and weak or thready pulse;

[0081] (3) Susceptible to colds, fatigue, or weak voice, restlessness, thirst, spontaneous sweating, and night sweats, which are easily induced or aggravated by wind and cold;

[0082] 1.3 Inclusion criteria

[0083] (1) Meet the above diagnostic criteria and be able to cooperate with the research treatment;

[0084] (2) The subjects voluntarily accept the clinical trial and sign the informed consent form;

[0085] (3) those with complete clinical data;

[0086] (4) Living in plateau areas for more than one month.

[0087] 1.4 Exclusion criteria

[0088] (1) Have used medications to treat throat diseases in the past 7 days;

[0089] (2) Pregnant or lactating women;

[0090] (3) Those who are allergic to this drug;

[0091] 1.5 Shedding Standard

[0092] (1) Severe adverse reactions, allergies, etc.

[0093] (2) Those who fail to take medication as prescribed;

[0094] (3) patients lost to follow-up;

[0095] (4) Those in the waiting group whose condition deteriorates sharply during the waiting period and who are in urgent need of medication.

[0096] The reasons for dropout are recorded for cases that drop out and are not included in the statistical data.

[0097] 1.6 Observation indicators

[0098] 1.6.1 Safety indicators

[0099] (1) If any adverse events occur during the study, their time of occurrence, clinical symptoms and signs, duration, severity, effective measures taken, and outcomes should be recorded in detail.

[0100] (2) General vital signs: body temperature, heart rate, respiration, blood pressure, etc.

[0101] 1.6.2 Efficacy indicators

[0102] (1) With reference to the “Standards for Diagnosis and Efficacy of Traditional Chinese Medicine Diseases” and “Introduction to the Four-Level Weighted Scoring Method for Clinical Diagnosis and Efficacy Judgment”, the symptoms and signs are divided into four levels according to their severity, and the clinical symptom and sign scoring grading quantitative table is formulated as follows:

[0103] Table 1: Four-level quantitative table for clinical symptom and sign scores

[0104]

[0105]

[0106] (2) Therapeutic index N (assessed by nimodipine method) = [(score before treatment - score after treatment / score before treatment)] × 100%.

[0107] Clinical cure: After treatment, the patient's symptoms return to normal, clinical signs basically disappear, and the efficacy index N ≥ 95%;

[0108] Markedly effective: After the treatment, the symptoms are equivalent to normal, most of the clinical signs disappear, and the efficacy index is met: 70% ≤ N < 95%;

[0109] Effective: After the treatment, the symptoms and signs are alleviated to a certain extent compared with before the treatment, but not very obvious, and meet the efficacy index: 30% ≤ N < 70%;

[0110] Ineffective: There is no significant change in symptoms and signs before and after treatment, basically no improvement, and the efficacy index N is less than 30%.

[0111] 1.7 Statistical analysis

[0112] After the clinical study was completed, the data were registered, a database was constructed, and statistical analysis was performed using SPSS26.0. If the data met the normal distribution, an independent sample t test was used between groups, and a paired sample t test was used within the group. If the data did not meet the normal distribution, a rank sum test was used. 2 The rank data were analyzed by Ridit, and the rank sum test was used for small sample size. P < 0.05 indicated that the difference between the two groups was statistically significant.

[0113] 2 Research results

[0114] 2.1 Safety evaluation

[0115] During this study, no adverse events occurred in the treatment group. Body temperature, heart rate, respiration, blood pressure and other indicators were stable and no abnormalities were found. Safety evaluation was level 1.

[0116] 2.2 Evaluation of efficacy

[0117] As shown in Table 2, there was no significant difference in the symptom and sign scores between the treatment group and the waiting group (P>0.05), and the two groups were comparable. After 7 days of treatment, the scores of various symptoms and signs in the treatment group were significantly reduced compared with those before treatment (P<0.05), and the symptoms of dry throat and dry mucosa were significantly reduced compared with those in the waiting group (P<0.05) (Table 3). After 14 days of treatment, the scores of various symptoms and signs in the treatment group were significantly reduced compared with those before treatment and the waiting group (P<0.05) (Table 4). After 7 days of treatment, 1 case of marked effect, 24 cases of effective, and the total effective rate was 83.33% in the treatment group (Table 5); after 14 days of treatment, 5 cases of cured, 5 cases of marked effect, 22 cases of effective, and the total effective rate was 93.33%, which were significantly better than those in the waiting group (Table 6).

[0118] Table 2 Symptom and sign scores of the two groups before treatment

[0119]

[0120] Note: The results are expressed as mean ± SD. The scores of symptoms and signs in the treatment group and the waiting group were compared. P>0.05. Table 3. Symptom and sign scores after 7 days of treatment

[0121]

[0122] Note: The results are expressed as mean ± SD; **p < 0.01, *p < 0.05, representing the treatment group compared with before treatment; # p<0.05, compared with the treatment group and the waiting group.

[0123] Table 4 Comparison of single symptom and sign scores between the two groups after 14 days of treatment

[0124]

[0125] Note: The results are expressed as mean ± SD; ****p<0.0001, ***p<0.001, **p<0.01, *p<0.05, representing the difference between the treatment group and the group before treatment; #### p<0.0001, ### p<0.001, ## p<0.01, # p<0.05, compared with the treatment group and the waiting group.

[0126] Table 5 Clinical efficacy of the two groups after 7 days of treatment (cases)

[0127]

[0128]

[0129] Table 6 Clinical efficacy of the two groups after 14 days of treatment (cases)

[0130]

[0131] In the description of this specification, specific features, structures, materials or characteristics may be combined in an appropriate manner in any one or more embodiments or examples.

[0132] The above is only a specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art can easily think of changes or substitutions within the technical scope disclosed by the present invention, which should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.

Claims

1. A Chinese medicine composition for treating chronic pharyngitis at high altitude, characterized in that: The invention comprises the following raw materials in parts by weight: 2-20 parts of ginseng, 2-30 parts of astragalus, 1-10 parts of dendrobium, 1-15 parts of wolfberry, 1-30 parts of atractylodes, 1-18 parts of thunbergii, 2-30 parts of momordica grosvenori, 1-15 parts of tangerine peel, 1-15 parts of mint, 1-15 parts of honeysuckle and 1-20 parts of chrysanthemum.

2. A Chinese medicine composition for treating chronic pharyngitis at high altitude according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 2-15 parts of ginseng, 2-20 parts of astragalus, 1-8 parts of dendrobium, 1-10 parts of wolfberry, 1-25 parts of atractylodes, 1-15 parts of thunbergii, 2-25 parts of momordica grosvenori, 1-12 parts of tangerine peel, 1-13 parts of mint, 1-10 parts of honeysuckle and 1-15 parts of chrysanthemum.

3. A Chinese medicine composition for treating high altitude chronic pharyngitis according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 2-10 parts of ginseng, 2-15 parts of astragalus, 1-5 parts of dendrobium, 1-8 parts of wolfberry, 1-20 parts of atractylodes, 1-12 parts of thunbergii, 2-20 parts of momordica grosvenori, 1-10 parts of tangerine peel, 1-10 parts of mint, 1-8 parts of honeysuckle and 1-10 parts of chrysanthemum.

4. A Chinese medicine composition for treating high altitude chronic pharyngitis according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 2-5 parts of ginseng, 2-10 parts of astragalus, 1-3 parts of dendrobium, 1-5 parts of wolfberry, 1-10 parts of atractylodes, 1-5 parts of thunbergii, 2-10 parts of momordica grosvenori, 1-5 parts of tangerine peel, 1-5 parts of mint, 1-5 parts of honeysuckle and 1-5 parts of chrysanthemum.

5. A Chinese medicine composition for treating chronic pharyngitis at high altitude according to claim 1, characterized in that: The invention comprises the following raw materials by weight: 2 parts of ginseng, 2 parts of astragalus, 1 part of dendrobium, 1 part of wolfberry, 1 part of atractylodes, 1 part of thunbergii, 2 parts of momordica, 1 part of tangerine peel, 1 part of mint, 1 part of honeysuckle and 1 part of chrysanthemum.

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