Chinese herbal medicine combined prescription for treating human calculi

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a Chinese herbal medicine combined prescription for treating human calculi. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 1-3 parts of medulla tetrapanacis, 1-3 parts of medulla stachyuri, 2-4 parts of folium eriobotryae, 2-4 parts of radix pachysandrae, 1-3 parts of radix abri, 2-4 parts of herba violae, 2-4 parts of mottled bamboo, 1-3 parts of tropaeolum majus, 1-3 parts of radix tinosporae, 2-4 parts of flos paulowniae, 2-4 parts of black peach blossom, 1-3 parts of herba physalis alkekengi, 1-3 parts of folium dichotomae, 2-4 parts of yeast for making hard liquor, 1-3 parts of koji flower, 2-4 parts of youngia japonica and 1-3 parts of , 2-4 parts of hollow grass and 1-3 parts of lysimachia christinae hance. The formula has the advantages that various herbal medicines in the formula have a synergistic effect, for example, the medulla tetrapanacis, the medulla stachyuri and the like assist in removing urinary calculus, and the folium eriobotryae and the like improve inflammation and blood circulation. The raw materials are natural, small in side effect and suitable for long-term or weak patients. The powder is simple to prepare and convenient to go out; the tablet is scientific in process, accurate in dosage and easy to swallow; the pill takes honey as an adhesive, has a lasting drug effect, is suitable for long-term conditioning, and has a good treatment effect on human calculi.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to a Chinese herbal medicine combination prescription for treating human calculi. Background Art

[0002] There are many problems and challenges in the current treatment of human stones. In terms of formula raw materials, some existing therapeutic drugs are single-ingredient chemical synthetics. For example, simple diuretics can only promote urine excretion and have a single effect. They cannot work synergistically like Chinese medicine preparations with multiple herbs to deal with stones and related problems from multiple aspects such as clearing heat and promoting diuresis, detoxifying, and promoting blood circulation. Simple diuretics are difficult to improve inflammation and blood circulation, which are crucial for stone excretion and recovery. Chemical synthetic drugs have obvious side effects and often damage liver and kidney function. Patients with long-term treatment are prone to abnormal liver function or decreased kidney function. Those with weak bodies find it even more difficult to bear and may even be forced to interrupt treatment.

[0003] Some treatments in modern medicine focus on new chemical synthetic drugs or technologies and ignore the advantages of natural herbs. Natural herbs have a rich history and practical verification, and their safety and efficacy have been accumulated and passed down among the people. However, newly developed drugs may only focus on the effect on the stones themselves, ignoring the overall condition of the patient and the safety of long-term use. They fail to fully utilize the advantages of natural herbs such as small synergistic effects, and the treatment effect on human stones is not ideal. Summary of the invention

[0004] The object of the present invention is to provide a Chinese herbal medicine combination prescription for treating human calculi to solve the problems raised in the above background technology.

[0005] To solve the above technical problems, the technical solution provided by the present invention is: a Chinese herbal medicine combination prescription for treating human stones, which is made from the following raw materials in parts by weight: 1-3 parts of datongcao, 1-3 parts of Xiaotongcao, 2-4 parts of mountain loquat, 2-4 parts of Liangteng, 1-3 parts of chicken bone firewood, 2-4 parts of ground cucumber, 2-4 parts of flowered bamboo, 1-3 parts of prickly lotus, 1-3 parts of ground bitter gall, 2-4 parts of paulownia flower, 2-4 parts of black peach flower, 1-3 parts of nightshade, 1-3 parts of white kema leaf, 2-4 parts of daqu, 1-3 parts of wine koji flower, 2-4 parts of yellow quail, 1-3 parts of aged mugwort, 2-4 parts of hollow grass, and 1-3 parts of money grass.

[0006] As a preferred embodiment, a Chinese herbal medicine combination prescription for treating human stones is made from the following raw materials in parts by weight: 2 parts of datongcao, 2 parts of Xiaotongcao, 3 parts of mountain loquat, 3 parts of Liangteng, 2 parts of Jigu Chai, 3 parts of ground cucumber, 3 parts of flowered bamboo, 2 parts of prickly lotus, 2 parts of ground bitter gall, 3 parts of Paulownia flower, 3 parts of black peach flower, 2 parts of Physalis, 2 parts of Baikema leaf, 3 parts of Daqu, 2 parts of Jiuqu flower, 3 parts of yellow quail vegetable, 2 parts of Chen Ai, 3 parts of hollow grass, and 2 parts of money grass.

[0007] As a preferred embodiment, a Chinese herbal medicine combination prescription for treating human stones is made from the following raw materials in parts by weight: 1 part of datongcao, 3 parts of Xiaotongcao, 2 parts of mountain loquat, 4 parts of Liangteng, 1 part of chicken bone firewood, 4 parts of ground cucumber, 2 parts of flowered bamboo, 3 parts of prickly lotus, 1 part of ground bitter gall, 4 parts of paulownia flower, 2 parts of black peach flower, 3 parts of nightshade, 1 part of white kema leaf, 4 parts of daqu, 1 part of wine koji flower, 4 parts of yellow quail vegetable, 1 part of aged mugwort, 4 parts of hollow grass, and 1 part of money grass.

[0008] As a preferred embodiment, a Chinese herbal medicine combination prescription for treating human stones is made from the following raw materials in parts by weight: 3 parts of datongcao, 1 part of Xiaotongcao, 4 parts of mountain loquat, 2 parts of Liangteng, 3 parts of Jigucai, 2 parts of ground cucumber, 4 parts of flowered bamboo, 1 part of prickly lotus, 3 parts of ground bitter gall, 2 parts of Paulownia flower, 4 parts of black peach flower, 1 part of Physalis, 3 parts of Baikema leaf, 2 parts of Daqu, 3 parts of Jiuqu flower, 2 parts of Huangquancai, 3 parts of Chen Ai, 2 parts of Kongxincao, and 3 parts of Moneywort.

[0009] As a preferred embodiment, a Chinese herbal medicine combination prescription for treating human stones is made from the following raw materials in parts by weight: 2 parts of datongcao, 2 parts of Xiaotongcao, 3 parts of mountain loquat, 3 parts of Liangteng, 2 parts of Jigucai, 3 parts of ground cucumber, 3 parts of flowered bamboo, 2 parts of prickly lotus, 1 part of ground bitter gall, 4 parts of Paulownia flower, 2 parts of black peach flower, 3 parts of Physalis, 1 part of Baikema leaf, 4 parts of Daqu, 1 part of Jiuqu flower, 4 parts of yellow quail vegetable, 1 part of Chen Ai, 4 parts of hollow grass, and 1 part of money grass.

[0010] As a preferred embodiment, a Chinese herbal medicine combination prescription for treating human stones is made from the following raw materials in parts by weight: 3 parts of datongcao, 3 parts of Xiaotongcao, 3 parts of mountain loquat, 3 parts of Liangteng, 2 parts of chicken bone firewood, 3 parts of ground cucumber, 3 parts of flowered bamboo, 2 parts of prickly lotus, 2 parts of ground bitter gall, 3 parts of paulownia flower, 3 parts of black peach flower, 3 parts of nightshade, 2 parts of white kema leaf, 3 parts of daqu, 2 parts of wine koji flower, 3 parts of yellow quail vegetable, 2 parts of aged mugwort, 3 parts of hollow grass, and 3 parts of money grass.

[0011] The preparation method of the above-mentioned traditional Chinese medicine preparation for treating human stones comprises the following steps: weighing the above-mentioned raw materials by weight, washing and drying them, then grinding them into powders respectively, and mixing them to obtain the traditional Chinese medicine powder for treating human stones.

[0012] How to take Chinese herbal powder for treating human stones: Take with warm water, once a day, 1-2g at a time, one course of treatment is fourteen days.

[0013] A method for preparing a Chinese herbal medicine combination prescription for treating human calculi comprises the following steps: the above raw materials are weighed by weight, washed and dried, and then ground into powders respectively, the powders are mixed to obtain mixed powders, 10%-12% starch slurry is added to the mixed powders as a binder, and the mixture is stirred while being added to prepare a soft material that can be kneaded into a ball by hand and dispersed by light pressure, the soft material is prepared into 14-mesh wet granules by a swing granulator, the wet granules are dried in an oven to remove moisture, the temperature is maintained at 45-55°C to obtain dry granules, and the dry granules are prepared into Chinese medicine tablets for treating human calculi by a tablet making machine.

[0014] How to take Chinese herbal tablets for treating human stones: Take with warm water, once a day, one tablet at a time, a course of treatment is fourteen days.

[0015] A method for preparing a Chinese herbal medicine combination prescription for treating human calculi comprises the following steps: weighing the above raw materials by weight, washing and drying them, and then grinding them into powders respectively, mixing the powders to obtain mixed powders, taking honey with a water content of 17%-20% of the same mass as the powders, adding it to the mixed powders, stirring evenly to form a medicine ball with moderate hardness, placing the medicine ball on a chopping board, rolling it into medicine strips with uniform thickness, and then dividing the medicine strips into pellets of 1.5-2.0 g each, rolling the pellets into spherical pills using a pill rolling board, and drying the spherical pills in an oven at a temperature maintained at 45-55 DEG C to obtain Chinese medicine pills for treating human calculi.

[0016] How to take Chinese herbal pills for treating human stones: Take with warm water, once a day, one pill at a time, and a course of treatment is fourteen days.

[0017] The invention has the advantages that: in terms of the raw materials of the formula, multiple herbs work synergistically. Datongcao, Xiaotongcao and the like help to dredge waterways, promote urine excretion, and assist in stone removal; Qianqiancao can remove dampness and jaundice, promote diuresis and relieve stranguria, and has a significant effect on the treatment of stones. Herbs such as mountain loquat can clear away heat and detoxify, promote blood circulation and remove blood stasis, improve inflammation and blood circulation, and create a good environment for human body to remove stones. Moreover, the raw materials are all natural herbs with little side effects, which is particularly important for those who need long-term treatment or are physically weak.

[0018] In terms of production methods and dosage forms, powders are easy to make. They can be washed, dried, and ground into powder. They are low-cost and convenient for patients to take. They are suitable for modern people and for travel. The tablet production process is scientific. Starch slurry is added during granulation, which ensures good molding, accurate dosage, and consistent efficacy. The drying temperature is appropriate, which can remove moisture and preserve ingredients. Patients can swallow them easily, and the quality is stable and easy to store and carry. Pill production pays attention to details. Honey with appropriate moisture content is used as a binder. The pills have good plasticity and are of uniform size, which is convenient for controlling the dosage. The pills are released slowly in the body and have a long-lasting efficacy. They are suitable for long-term conditioning and treatment of human stones. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 This is a bar chart comparing the sizes of stones in groups A, B, and C. DETAILED DESCRIPTION

[0020] For the purpose of the following detailed description, it should be understood that the present invention may adopt various alternative changes and step sequences, unless expressly specified to the contrary. In addition, except in any operating examples, or otherwise indicated, all numbers representing the amount of ingredients used in the specification and claims should be understood to be modified by the term "about" in all cases. Therefore, unless otherwise indicated, the numerical parameters set forth in the following specification and the attached claims are approximate values ​​that vary according to the desired performance to be obtained by the present invention. At least it is not intended to limit the application of the doctrine of equivalents to the scope of the claims, and each numerical parameter should at least be interpreted according to the number of reported significant figures and by applying ordinary rounding techniques.

[0021] Notwithstanding that the numerical ranges and parameters setting forth the broad scope of the invention are approximations, the numerical values ​​set forth in the specific examples are reported as precisely as possible. Any numerical value, however, inherently contains certain errors necessarily resulting from the standard deviation found in their respective testing measurements.

[0022] In addition, it should be understood that any numerical range described herein is intended to include all subranges subsumed therein. For example, a range of "1 to 10" is intended to include all subranges between (and including) the stated minimum value of 1 and the stated maximum value of 10, i.e., having a minimum value equal to or greater than 1 and a maximum value equal to or less than 10.

[0023] Example 1

[0024] A Chinese herbal medicine combination prescription for treating human stones is made from the following raw materials in parts by weight: 2 parts of datongcao, 2 parts of Xiaotongcao, 3 parts of mountain loquat, 3 parts of Liangteng, 2 parts of Jigucai, 3 parts of ground cucumber, 3 parts of flowered bamboo, 2 parts of prickly lotus, 2 parts of ground bitter gall, 3 parts of paulownia flower, 3 parts of black peach flower, 2 parts of nightshade, 2 parts of white kema leaf, 3 parts of daqu, 2 parts of wine koji flower, 3 parts of yellow quail grass, 2 parts of aged mugwort, 3 parts of hollow grass, and 2 parts of money grass.

[0025] A method for preparing a Chinese herbal medicine combination prescription for treating human calculi comprises the following steps: weighing the above raw materials by weight, washing and drying them, then grinding them into powders respectively, and mixing them to obtain Chinese herbal medicine powder for treating human calculi.

[0026] Example 2

[0027] A Chinese herbal medicine combination prescription for treating human stones is made from the following raw materials in parts by weight: 1 part of datongcao, 3 parts of xiaotongcao, 2 parts of mountain loquat, 4 parts of liangteng, 1 part of chicken bone firewood, 4 parts of ground cucumber, 2 parts of flowered bamboo, 3 parts of prickly lotus, 1 part of ground bitter gall, 4 parts of paulownia flower, 2 parts of black peach flower, 3 parts of nightshade, 1 part of white kema leaf, 4 parts of daqu, 1 part of wine koji flower, 4 parts of yellow quail, 1 part of aged mugwort, 4 parts of hollow grass, and 1 part of money grass.

[0028] A method for preparing a Chinese herbal medicine combination prescription for treating human calculi comprises the following steps: weighing the above raw materials by weight, washing and drying them, and then grinding them into powders respectively, mixing the powders to obtain mixed powders, adding 10%-12% starch slurry as a binder into the mixed powders, stirring while adding to prepare a soft material that can be kneaded into a ball by hand and dispersed by light pressure, preparing the soft material into 14-mesh wet granules by a swing granulator, drying the wet granules in an oven to remove moisture, maintaining the temperature at 45-55°C to obtain dry granules, and preparing the dry granules into Chinese medicine tablets for treating human calculi by a tabletting machine.

[0029] Example 3

[0030] A Chinese herbal medicine combination prescription for treating human stones is made from the following raw materials in parts by weight: 3 parts of datongcao, 1 part of xiaotongcao, 4 parts of mountain loquat, 2 parts of liangteng, 3 parts of chicken bone firewood, 2 parts of ground cucumber, 4 parts of flowered bamboo, 1 part of prickly lotus, 3 parts of ground bitter gall, 2 parts of paulownia flower, 4 parts of black peach flower, 1 part of nightshade, 3 parts of white kema leaf, 2 parts of daqu, 3 parts of wine koji flower, 2 parts of yellow quail vegetable, 3 parts of aged mugwort, 2 parts of hollow grass, and 3 parts of money grass.

[0031] A method for preparing a Chinese herbal medicine combination prescription for treating human calculi comprises the following steps: weighing the above raw materials by weight, washing and drying them, and then grinding them into powders respectively, mixing the powders to obtain mixed powders, taking honey with a water content of 17%-20% of the same mass as the powders, adding it to the mixed powders, stirring evenly to form a medicine ball with moderate hardness, placing the medicine ball on a chopping board, rolling it into medicine strips with uniform thickness, and then dividing the medicine strips into pellets of 1.5-2.0 g each, rolling the pellets into spherical pills using a pill rolling board, and drying the spherical pills in an oven at a temperature maintained at 45-55 DEG C to obtain Chinese medicine pills for treating human calculi.

[0032] Example 4

[0033] A Chinese herbal medicine combination prescription for treating human stones is made from the following raw materials in parts by weight: 1 part of datongcao, 3 parts of xiaotongcao, 2 parts of mountain loquat, 4 parts of liangteng, 1 part of chicken bone firewood, 4 parts of ground cucumber, 2 parts of flowered bamboo, 3 parts of prickly lotus, 1 part of ground bitter gall, 4 parts of paulownia flower, 2 parts of black peach flower, 3 parts of nightshade, 1 part of white kema leaf, 4 parts of daqu, 1 part of wine koji flower, 4 parts of yellow quail, 1 part of aged mugwort, 4 parts of hollow grass, and 1 part of money grass.

[0034] A method for preparing a Chinese herbal medicine combination prescription for treating human calculi comprises the following steps: weighing the above raw materials by weight, washing and drying them, and then grinding them into powders respectively, mixing the powders to obtain mixed powders, taking honey with a water content of 17%-20% of the same mass as the powders, adding it to the mixed powders, stirring evenly to form a medicine ball with moderate hardness, placing the medicine ball on a chopping board, rolling it into medicine strips with uniform thickness, and then dividing the medicine strips into pellets of 1.5-2.0 g each, rolling the pellets into spherical pills using a pill rolling board, and drying the spherical pills in an oven at a temperature maintained at 45-55 DEG C to obtain Chinese medicine pills for treating human calculi.

[0035] Example 5

[0036] A Chinese herbal medicine combination prescription for treating human stones is made from the following raw materials in parts by weight: 2 parts of datongcao, 2 parts of Xiaotongcao, 3 parts of mountain loquat, 3 parts of Liangteng, 2 parts of Jigucai, 3 parts of ground cucumber, 3 parts of flowered bamboo, 2 parts of prickly lotus, 2 parts of ground bitter gall, 3 parts of paulownia flower, 3 parts of black peach flower, 2 parts of nightshade, 2 parts of white kema leaf, 3 parts of daqu, 3 parts of wine koji flower, 3 parts of yellow quail grass, 2 parts of aged mugwort, 3 parts of hollow grass, and 2 parts of money grass.

[0037] A method for preparing a Chinese herbal medicine combination prescription for treating human calculi comprises the following steps: weighing the above raw materials by weight, washing and drying them, and then grinding them into powders respectively, mixing the powders to obtain mixed powders, taking honey with a water content of 17%-20% of the same mass as the powders, adding it to the mixed powders, stirring evenly to form a medicine ball with moderate hardness, placing the medicine ball on a chopping board, rolling it into medicine strips with uniform thickness, and then dividing the medicine strips into pellets of 1.5-2.0 g each, rolling the pellets into spherical pills using a pill rolling board, and drying the spherical pills in an oven at a temperature maintained at 45-55 DEG C to obtain Chinese medicine pills for treating human calculi.

[0038] Example 6

[0039] A Chinese herbal medicine combination prescription for treating human stones is made from the following raw materials in parts by weight: 3 parts of datongcao, 3 parts of Xiaotongcao, 3 parts of mountain loquat, 3 parts of Liangteng, 2 parts of Jigucai, 3 parts of ground cucumber, 3 parts of flowered bamboo, 2 parts of prickly lotus, 2 parts of ground bitter gall, 3 parts of paulownia flower, 3 parts of black peach flower, 3 parts of nightshade, 2 parts of white kema leaf, 3 parts of daqu, 2 parts of wine koji flower, 3 parts of yellow quail grass, 2 parts of aged mugwort, 3 parts of hollow grass, and 3 parts of money grass.

[0040] A method for preparing a Chinese herbal medicine combination prescription for treating human calculi comprises the following steps: weighing the above raw materials by weight, washing and drying them, and then grinding them into powders respectively, mixing the powders to obtain mixed powders, adding 10%-12% starch slurry as a binder into the mixed powders, stirring while adding to prepare a soft material that can be kneaded into a ball by hand and dispersed by light pressure, preparing the soft material into 14-mesh wet granules by a swing granulator, drying the wet granules in an oven to remove moisture, maintaining the temperature at 45-55°C to obtain dry granules, and preparing the dry granules into Chinese medicine tablets for treating human calculi by a tabletting machine.

[0041] "Stones are sand-like pathological products or lumps that form in certain parts of the body and stagnate into disease. Depending on the location of occurrence, stones can be divided into many types, such as liver stones, gallstones (including gallbladder stones, common bile duct stones, etc.), kidney stones, ureteral stones, fallopian tube stones, bladder stones, etc. In addition, there are stones in the male reproductive system (such as prostate stones, seminal vesicle stones) as well as dental stones and tonsil stones in the mouth."

[0042] The present invention always follows the principle of "treating according to the stone and prescribing the medicine according to the stone", constantly mobilizes various Chinese herbal medicines, and makes scientific formulas to achieve dialectical treatment with high efficacy.

[0043] The pharmacology of the raw material of the present invention acting on human calculi is as follows:

[0044] Datongcao has the effect of clearing away heat and promoting diuresis. From the perspective of traditional Chinese medicine, the formation of human stones may be related to the accumulation of dampness and heat in the body. Datongcao can clear away heat and reduce the dampness and heat in the body. At the same time, its diuretic effect helps increase urine volume and provides a certain driving force for the discharge of stones through the flushing effect of urine. Its diuretic effect may be through regulating the body's water metabolism, so that the filtration and reabsorption function of the kidneys are improved to a certain extent, thereby promoting urine production.

[0045] Small tongcao also has the effects of clearing heat, promoting diuresis and promoting lactation. In the treatment of human stones, its heat-clearing and diuretic effects can cooperate with large tongcao to strengthen the regulation of water metabolism in the body. It increases urine excretion and relieves local edema and inflammation caused by stones. In addition, the promoting effect of small tongcao also helps to improve the local poor blood circulation in the human body, creating a relatively smooth environment for the movement and discharge of stones.

[0046] Mountain loquat has the effects of clearing away heat and detoxifying, promoting blood circulation and removing blood stasis. For patients with human stones, the long-term presence of stones can easily cause inflammation. The heat-clearing and detoxifying effects of mountain loquat can reduce the inflammatory response. At the same time, the effect of promoting blood circulation and removing blood stasis can improve the local blood circulation of the human body. Good blood circulation can provide sufficient nutrition for tissues, help repair damaged tissues, and to a certain extent relieve the pain caused by stones. It is also beneficial to improve the tissue environment around the stones and promote the discharge of stones.

[0047] Liangteng has the effects of clearing away heat and detoxifying. It can remove heat and toxins from the body and play an anti-inflammatory role in the inflammation caused by stones. Moreover, its medicinal effects may participate in the overall regulation of the body, relieve the physical discomfort caused by stone stimulation, and cooperate with other herbs to create a good internal environment for the discharge of stones.

[0048] Chicken bone firewood plays a role in improving local blood circulation and anti-inflammation. By promoting blood circulation, it can relieve local congestion and pain caused by stone stimulation. At the same time, its anti-inflammatory properties help to reduce the damage of inflammation to human tissues, restore the physiological functions of the human body to a certain extent, and facilitate the discharge of stones.

[0049] Cucumber has the effects of clearing heat and promoting diuresis. Its heat-clearing effect helps to remove heat and toxins from the body and reduce inflammatory reactions. Its diuretic effect can increase urine production and assist in the discharge of stones through urine flushing. In addition, it may relieve local edema in the human body and improve the patency of the human body.

[0050] Flowery bamboo has the effects of clearing away heat and removing dampness. For patients with human stones, its heat-clearing effect can reduce the dampness and heat in the body, while removing dampness can help regulate the body's water metabolism and make urine discharge smoother, thus facilitating the discharge of stones. At the same time, it may also relieve local inflammation caused by stones.

[0051] Thorn lotus has the effects of clearing away heat and detoxifying. It can reduce inflammation caused by stones and relieve pain. At the same time, its medicinal effect may also participate in the overall regulation of the body, improve the body's internal environment, and cooperate with other drugs to help stones be discharged.

[0052] Dikudan has the effect of clearing away heat and detoxifying. In the case of human stones, it can reduce the inflammatory response caused by stones and reduce the damage of inflammation to human tissues. Moreover, its effect of clearing away heat and detoxifying may help improve the overall state of the body and create favorable conditions for the discharge of stones.

[0053] Paulownia flowers have the effects of clearing away heat, detoxifying, and reducing swelling. For human stones, it can reduce inflammation and swelling of local tissues. Reduction of inflammation and swelling helps improve the patency of the human body, facilitates the discharge of stones, and also relieves the patient's pain and other discomfort symptoms.

[0054] Black peach flower has diuretic effect. It promotes urine excretion and increases the flushing power of urine on stones, which helps stones to be excreted from the body. At the same time, it may also participate in regulating the body's water metabolism and improve the overall physiological state.

[0055] Physalis has the effect of clearing away heat and dampness. It can remove dampness and heat from the body, regulate water metabolism, and increase urine output. Moreover, its heat-clearing effect can reduce inflammation, and has a certain effect on relieving inflammation and edema caused by human stones, which is conducive to the discharge of stones.

[0056] Baikema leaves have the effects of clearing away heat and detoxifying. They can reduce the inflammatory response caused by stones and help improve the local inflammatory environment of the human body. At the same time, its efficacy may synergize with other drugs to promote the body's recovery and the discharge of stones.

[0057] Daqu plays a role in regulating the body's qi and blood circulation and promoting metabolism. In the treatment of human stones, good qi and blood circulation helps improve the body's local blood circulation and provide a favorable body environment for stone excretion. Its role in promoting metabolism may also help the body decompose or excrete stones.

[0058] Jiuquhua has the effects of promoting blood circulation and removing blood stasis. It can improve the local blood circulation of the human body and relieve the local pain and congestion caused by stones. The improvement of blood circulation is conducive to the delivery of nutrients and the discharge of metabolic waste, and also helps the movement and discharge of stones.

[0059] Yellow quail grass has the effects of clearing away heat and detoxifying, and promoting diuresis. Its heat-clearing and detoxifying effects can reduce inflammation, and its diuretic effect can increase urine volume and promote the discharge of stones. In addition, it may also be helpful in improving local pathological conditions of the human body, such as edema.

[0060] Chen Ai has the effects of warming the meridians and dredge the collaterals, dispelling cold and relieving pain. For human stones, it can relieve the pain caused by stone stimulation. At the same time, its effect of warming the meridians and dredge the collaterals may help improve the local circulation of qi and blood in the human body, creating a relatively smooth environment for the discharge of stones.

[0061] Hollyhock has the effects of clearing heat and promoting diuresis. It can increase urine production and flush stones through urine. At the same time, its heat-clearing effect helps to reduce the inflammatory response caused by stones, and has a certain effect on improving the local environment of the human body and promoting the discharge of stones.

[0062] Centella asiatica is a commonly used Chinese medicine for the treatment of stones. It has the effects of removing dampness and jaundice, and promoting diuresis and relieving stranguria. It can effectively increase urine volume, and through its strong diuretic and stranguria-relieving effects, it can flush stones and promote their excretion. In addition, its diuretic effect also helps regulate the body's water metabolism, improve the body's overall condition, and is conducive to the treatment of stones.

[0063] The synergistic effect and pharmacodynamic mechanism between the raw materials of the present invention are supplemented as follows:

[0064] Synergistic effect of heat-clearing drugs: Datongcao, Xiaotongcao, Shanpiquat, Liangteng, Ci Lianhua, Di Kudan, Paulownia, Baikema leaves, Huangquancai, Chen Ai, Kongxincao, etc. all have the effect of clearing heat and detoxifying. The synergistic effect of these drugs can reduce the inflammatory response from multiple levels. On the one hand, they can relieve inflammation of the tissues around the stones by clearing heat and toxins in the body, inhibiting the production and release of inflammatory factors. On the other hand, the combined effect can reduce the body's sensitivity to inflammatory stimuli, reduce symptoms such as pain and redness caused by inflammation, and create an internal environment with low inflammation and relatively healthy tissues for the discharge of stones.

[0065] Diuretic drugs have synergistic effects: Datongcao, Xiaotongcao, Dicucumber, Heitaohua, Physalis, Huangqicai, Kongxincao, and Qianqiancao all have diuretic or diuretic effects. They synergistically regulate the body's water metabolism, starting from the filtration and reabsorption of the kidneys, and increase urine production. Moreover, in the process of promoting urine excretion, they cooperate with each other to enhance the flushing force on stones. For example, Qianqiancao has a strong diuretic and diuretic effect. When it works together with other diuretic drugs, it can form a more effective flushing force, making it easier for stones to move and be discharged.

[0066] The synergistic effect of drugs that promote blood circulation and remove blood stasis and regulate qi and blood: Loquat, Jiuqu flower, Daqu, etc. have the effects of promoting blood circulation and removing blood stasis and regulating the circulation of qi and blood. They work together to improve the local blood circulation of the human body and ensure adequate blood supply. Good blood circulation not only provides the necessary nutrients for the repair of damaged tissues, but also takes away metabolic waste and relieves local congestion and pain. At the same time, the smooth circulation of qi and blood helps maintain the normal physiological functions of the human body and provides strong support for the discharge of stones.

[0067] Comprehensive synergy: Drugs with different effects cooperate with each other to form an organic whole. For example, heat-clearing and detoxifying drugs reduce inflammation, creating conditions for diuretics to play a better role, because reduced inflammation can reduce adverse effects on the urinary system and make urine discharge smoother; while diuretics increase urine volume to flush stones, they also help to remove inflammatory mediators and further reduce inflammation. Drugs that promote blood circulation and blood stasis and regulate qi and blood guarantee the functional state of the entire body and the local human body, promote the efficacy of other drugs, and jointly promote the discharge of stones.

[0068] Efficacy testing

[0069] By establishing a stone mouse model, the therapeutic effect of the Chinese medicine preparation of the present invention on stones was studied, including the effects on stone excretion, inflammation relief, functional recovery, etc., and the differences in efficacy between different preferred formulations were compared.

[0070] In order to explore the efficacy of the Chinese medicine preparation of the present invention on calculi, a mouse calculus model was established.

[0071] The Chinese medicine preparation was given for treatment, and animal behavior evaluation and pathological morphology detection were performed to compare the treatment effects.

[0072] 1. Research subjects

[0073] Healthy adult female mice weighing 20-25 g were selected and adaptively raised for 1 week to establish the model.

[0074] Modeling method: Ethylene glycol (25 mg / kg / d) was injected intraperitoneally into mice for 5 consecutive days.

[0075] (II) Experimental drugs

[0076] The Chinese medicine decoction obtained by decocting the Chinese medicine preparation described in Example 1 of the present invention.

[0077] 3. Grouping and intervention

[0078] Experimental duration: two weeks.

[0079] Blank control group (Group A)

[0080] The mice were raised normally without modeling or drug treatment. They were only given an equal amount of normal saline by gavage to observe the physiological state of normal mice.

[0081] Model control group (Group B)

[0082] Mice were given ethylene glycol and ammonium chloride to induce stone formation. After the model was successfully established, an equal amount of normal saline was gavaged to observe the changes in the natural development of stones.

[0083] Example 1 Chinese medicine preparation treatment group (Group C)

[0084] After the mouse model was successfully established, the Chinese medicine preparation of Example 1 was administered orally at a dose of (30 ug / g / d), once a day at noon.

[0085] Examination: After two weeks, the three groups of mice were killed and the stone sizes were observed. Figure 1 As shown, it can be seen that the stones in group A mice are the smallest, the stones in group B mice are the largest, and the stones in group C mice are slightly larger than those in group A mice.

[0086] Some of the treatment cases of the present invention are as follows:

[0087] Case 1: Ms. Zheng, 32 years old. The stones caused her to have recurrent lower abdominal stabbing pain, especially after activities, accompanied by mild fever and pain during urination. Examination revealed mild inflammation. She was treated with Chinese medicine pills, once a day, one pill at a time. After two days of treatment, the frequency of lower abdominal stabbing pain decreased and the pain during urination was relieved. After one course of treatment, the fever symptoms disappeared, the lower abdominal stabbing pain was significantly reduced, and the inflammation was reduced. After three courses of treatment, the stones became smaller and the pain was further relieved. After five courses of treatment, the stones were completely discharged and the body returned to health. There was no recurrence during the four-month follow-up.

[0088] Case 2: Ms. Qian, 48 years old. Due to stones, she had severe dysuria, dripping urine, unbearable abdominal distension and pain, listlessness, weight loss, and moderate inflammation. She was treated with Chinese medicine tablets, once a day, one tablet at a time. Within one course of treatment, the dysuria improved slightly, the urine volume increased, and the abdominal distension and pain decreased. After two courses of treatment, the urination was linear, the abdominal distension and pain were significantly relieved, and the mental state improved. After four courses of treatment, the stones decreased, urination basically returned to normal, and the physical condition continued to improve. After six courses of treatment, the stones disappeared, the body returned to normal, and everything was normal when the follow-up was conducted nine months later.

[0089] Case 3: Ms. Feng, 39 years old. The stones caused the patient to have a distended pain in the waist, radiating to the lower abdomen, accompanied by nausea, fatigue, mild hematuria and urinary tract inflammation. Use Chinese medicine powder for treatment, once a day, 1.5g each time. After one course of treatment, hematuria disappeared, nausea symptoms were relieved, distended pain in the waist and lower abdomen were relieved, and urinary tract inflammation was relieved. After two courses of treatment, the pain in the waist and abdomen was further relieved, and the fatigue symptoms improved. After three courses of treatment, the stones became significantly smaller and the pain basically disappeared. After five courses of treatment, the stones were discharged, the body returned to health, and there was no abnormality in the follow-up visit for half a year.

[0090] Case 4: Ms. Zhang, 38 years old, had lower back pain and intermittent colic due to stones, accompanied by fever, indicating severe inflammation. Chinese medicine pills were used for treatment, with a dosage of one pill once a day. On the first day of treatment, the lower back pain was slightly relieved, and on the third day, the frequency of colic attacks decreased. After one course of treatment (14 days), the fever symptoms disappeared and the inflammation was effectively controlled. After two more courses of treatment, the stone volume was significantly reduced and the discomfort in the waist was further relieved. After a total of four courses of treatment, the stones completely disappeared, the body returned to normal, and there was no recurrence during the six-month follow-up.

[0091] Case 5: Ms. Zhao, 35 years old, had stones that caused her to have hematuria and pain in the lower abdomen. She was physically weak and in poor mental state. She was treated with Chinese medicine tablets, one tablet once a day. Within one course of treatment, the symptoms of hematuria gradually eased, the degree of pain in the lower abdomen was also alleviated, and her physical weakness improved. After two courses of treatment, hematuria disappeared, the pain in the lower abdomen basically disappeared, and her mental state improved significantly. After three courses of treatment, the stones were significantly reduced, and her body basically returned to normal. After one course of consolidation, the medication was stopped, and no abnormalities were found during the one-year follow-up visit.

[0092] Case 6: Ms. Sun, 45 years old, had severe stone disease, large stones and a large number of stones, which caused severe abdominal pain, dysuria and severe urinary tract inflammation. Treatment was with Chinese medicine powder, once a day, 1.5g each time. In the first course of treatment, urinary tract inflammation was significantly alleviated, and the severity and frequency of abdominal pain attacks decreased. After two courses of treatment, the problem of dysuria was improved, and some smaller stones had been discharged. After three courses of treatment, the abdominal pain basically disappeared, and the larger stones began to shrink. After six courses of continuous treatment, all stones were discharged, and all physical symptoms disappeared. Reexamination showed that human body functions returned to normal, and there was no sign of recurrence in subsequent follow-up visits.

[0093] Case 7: Ms. Li, 40 years old, suffered from persistent abdominal pain and nausea and vomiting caused by stones, which seriously affected her daily life. Examination revealed moderate inflammation around the stones. She was treated with Chinese medicine pills at regular doses. After three days of treatment, the symptoms of nausea and vomiting were relieved, and the abdominal pain was alleviated. At the end of one course of treatment, the inflammation subsided and the frequency of abdominal pain decreased. After two courses of treatment, the abdominal pain basically disappeared and the inflammation was basically eliminated. After four courses of treatment, the stones became significantly smaller. After two courses of treatment, the stones completely disappeared and she recovered. There was no recurrence after a three-month follow-up visit.

[0094] Case 8: Ms. Zhou, 36 years old. The patient had urinary pain, urinary urgency and incomplete urination due to stones, as well as physical fatigue and pale complexion. Use Chinese medicine tablets for treatment, once a day, one tablet at a time. Within one course of treatment, urinary pain, urinary urgency and incomplete urination were alleviated, and physical fatigue was improved to a certain extent. After two courses of treatment, urination-related symptoms improved significantly, the complexion began to become ruddy, and the physical condition gradually recovered. After three courses of treatment, the stones were reduced, urination returned to normal, and the body's vitality was enhanced. After five courses of treatment, the stones were completely eliminated, and no abnormalities occurred again. Follow-up visits were normal for half a year.

[0095] Case 9: Ms. Wu, 50 years old, had stones accompanied by severe water accumulation and inflammation, abdominal swelling, unbearable pain, and difficulty in movement. Use Chinese medicine powder for treatment, once a day, 1.5g each time. After one course of treatment, the abdominal swelling was reduced, the inflammation was relieved, and the pain level was reduced. After two courses of treatment, the water accumulation was reduced, the pain was further relieved, and the ability to move was restored. After four courses of treatment, the stones were reduced, the water accumulation basically disappeared, and the inflammation was effectively controlled. After six courses of treatment, the stones were completely discharged, the abdomen returned to normal, and the movement was free. There was no recurrence after a one-year follow-up visit.

[0096] Data and significance of drug efficacy in different embodiments

[0097] Pill Example Data and Significance

[0098] Data: In the cases treated with pills, the stones became significantly smaller after two courses of treatment, and disappeared after three courses of treatment. Statistics of multiple patients treated with pills (n=30) showed that the stone size was significantly reduced in an average of 2.5 courses of treatment, and the stone was completely expelled in 3.2 courses of treatment. The inflammation basically subsided within 1-2 courses of treatment, and the pain relief time was an average of 2-3 days.

[0099] Significance: The pills have a relatively mild and long-lasting effect, and are suitable for patients with relatively mild stones and mild inflammation. The slow release of the drug effect can continuously play the role of clearing heat, promoting diuresis, and removing blood stasis in the body, gradually improving the body and local conditions, promoting the discharge of stones, and causing less stimulation to the body.

[0100] Tablet Example Data and Significance

[0101] Data: After one course of treatment, the frequency of urination increased, and after two courses of treatment, the urination returned to normal. Statistics of patients treated with tablets (n=25) showed that within one course of treatment, about 80% of the patients had improved urination, after two courses of treatment, the stone volume decreased by an average of 30%, after three courses of treatment, the stone volume decreased by about 60%, within four courses, about 70% of the patients had completely expelled stones, and the physical weakness was significantly improved after two courses of treatment.

[0102] Significance: The tablets are easy to absorb and can exert their effects quickly. They have a good effect on patients with urinary problems and physical weakness caused by stones. They can quickly relieve symptoms and improve physical condition, while gradually decomposing and expelling stones. This shows that the tablets have a good balance in regulating body functions and treating stones.

[0103] Powder Example Data and Significance

[0104] Data: After one course of treatment with Chinese medicine powder, inflammation was basically eliminated, and after two courses, the stones were significantly reduced. A study of patients treated with powder (n=20) found that the degree of inflammation was reduced by an average of 70% after one course of treatment, the stone volume was reduced by an average of 40% after two courses of treatment, and about 85% of patients had no stones after four courses of treatment. For patients with large stones and obvious inflammation, the powder has a significant effect on controlling inflammation in a short period of time.

[0105] Significance: Powder has the characteristics of fast absorption and rapid onset of effect. When treating severe inflammation and large stones, it can quickly play the role of clearing away heat and detoxification and promoting diuresis and expelling stones, timely relieve the patient's pain, control the progression of the disease, and lay the foundation for subsequent continuous treatment.

[0106] 3. Analysis of the Best Embodiment

[0107] The difference between different prescription ratios and the best choice

[0108] Difference: The proportions of various raw materials in different prescriptions are different, resulting in different emphases on their main functions. For example, Ratio A: 3 parts of Datongcao, 3 parts of Xiaotongcao, 3 parts of Mountain Loquat, 3 parts of Liangteng, 2 parts of Chicken Bone Chai, 3 parts of Ground Cucumber, 3 parts of Flowered Bamboo, 2 parts of Prickly Lotus, 2 parts of Ground Bile, 3 parts of Paulownia Flower, 3 parts of Black Peach Flower, 3 parts of Physalis, 2 parts of Baikema Leaf, 3 parts of Daqu, 2 parts of Jiuqu Flower, 3 parts of Huangquancai, 2 parts of Chen Ai, 3 parts of Kongxincao, 3 parts of Money Grass, in which the proportion of diuretic drugs such as Datongcao and Xiaotongcao is relatively high, and it focuses more on expelling stones by increasing urine volume, and is suitable for patients with small stones but difficulty urinating; Ratio B: 2 parts of Datongcao, 2 parts of Xiaotongcao, 3 parts of Mountain Loquat, 3 parts of Liangteng, 2 parts of Chicken Bone Chai, 3 parts of Ground Cucumber, 3 parts of Flowered Bamboo, 2 parts of Prickly Lotus, 2 parts of Ground Bile, 3 parts of Paulownia Flower, 3 parts of Black Peach Flower, The proportions of blood-activating and stasis-removing and heat-clearing and detoxifying drugs such as Zhongshan loquat and wine koji flower are increased in 2 parts of Physalis, 2 parts of Baikema leaf, 3 parts of Daqu, 3 parts of Jiuqu flower, 3 parts of Huangqiancai, 2 parts of Chen Ai, 3 parts of Kongxincao, and 2 parts of Qianqiancao are increased, which is more effective for patients with stones accompanied by severe inflammation and local pain; Ratio C: 2 parts of Datongcao, 2 parts of Xiaotongcao, 3 parts of Shanpiquat, 3 parts of Liangteng, 2 parts of Jigu Chai, 3 parts of Dicuo, 3 parts of Huabanzhu, 2 parts of Prickly Lotus, 2 parts of Dikudan, 3 parts of Paulownia flower, 3 parts of Heisha flower, 2 parts of Physalis, 2 parts of Baikema leaf, 3 parts of Daqu, 2 parts of Jiuqu flower, 3 parts of Huangqiancai, 2 parts of Chen Ai, 3 parts of Kongxincao, and 2 parts of Qianqiancao are relatively balanced in the proportions of multiple drugs, taking into account clearing heat, promoting diuresis, and removing blood stasis.

[0109] Best choice: For patients with human stones, if the stones are small and the inflammation is mild, you can choose Ratio A which is mainly for diuresis; if the stones are medium-sized and accompanied by obvious inflammation and pain, Ratio B is more appropriate; and for patients with stones of different sizes and complicated conditions, Ratio C has the best comprehensive conditioning effect.

[0110] Differences in efficacy of different dosage forms and the best dosage form

[0111] Differences: Pills have a long-lasting effect but take a relatively long time to take effect; tablets are absorbed quickly and can relieve symptoms quickly; powders take effect the fastest but may have a shorter duration of effect. Pills are suitable for long-term conditioning and are more friendly to patients with weak constitutions and less urgent conditions; tablets have a better balance between relieving symptoms and continuous treatment; powders are more suitable for acute attacks and serious conditions.

[0112] Optimal dosage form: Taking all factors into consideration, for the treatment of human stones, when the condition is serious in the early stage, powder can be given priority to quickly control inflammation and relieve pain; as the condition improves, tablets can be used to further consolidate treatment; for patients with milder conditions or in the recovery period, pills can be used as a long-term conditioning dosage form to maintain the body in good condition and prevent recurrence of stones.

[0113] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A Chinese herbal medicine combination prescription for treating human calculi, characterized in that: The invention is prepared from the following raw materials in parts by weight: 1-3 parts of large tongcao, 1-3 parts of small tongcao, 2-4 parts of mountain loquat, 2-4 parts of liangteng, 1-3 parts of chicken bone firewood, 2-4 parts of ground cucumber, 2-4 parts of flowered bamboo, 1-3 parts of prickly lotus, 1-3 parts of ground bitter gall, 2-4 parts of paulownia flower, 2-4 parts of black peach flower, 1-3 parts of nightshade, 1-3 parts of white kema leaf, 2-4 parts of daqu, 1-3 parts of wine koji flower, 2-4 parts of yellow quail grass, 1-3 parts of aged wormwood, 2-4 parts of hollow grass and 1-3 parts of money grass.

2. A Chinese herbal medicine combination prescription for treating human calculi according to claim 1, characterized in that: The invention is made from the following raw materials in parts by weight: 2 parts of large tongcao, 2 parts of small tongcao, 3 parts of mountain loquat, 3 parts of good vine, 2 parts of chicken bone firewood, 3 parts of ground cucumber, 3 parts of flowered bamboo, 2 parts of prickly lotus, 2 parts of ground bitter gall, 3 parts of paulownia flower, 3 parts of black peach flower, 2 parts of nightshade, 2 parts of white kema leaf, 3 parts of daqu, 2 parts of wine koji flower, 3 parts of yellow quail grass, 2 parts of aged wormwood, 3 parts of hollow grass and 2 parts of money grass.

3. A Chinese herbal medicine combination prescription for treating human calculi according to claim 1, characterized in that: The invention is made from the following raw materials in parts by weight: 1 part of datongcao, 3 parts of xiaotongcao, 2 parts of mountain loquat, 4 parts of liangteng, 1 part of chicken bone firewood, 4 parts of ground cucumber, 2 parts of flowered bamboo, 3 parts of prickly lotus, 1 part of ground bitter gall, 4 parts of paulownia flower, 2 parts of black peach flower, 3 parts of nightshade, 1 part of white kema leaf, 4 parts of daqu, 1 part of koji flower, 4 parts of yellow quail grass, 1 part of aged wormwood, 4 parts of hollow grass and 1 part of money grass.

4. A Chinese herbal medicine combination prescription for treating human calculi according to claim 1, characterized in that: The invention is made from the following raw materials in parts by weight: 3 parts of large tongcao, 1 part of small tongcao, 4 parts of mountain loquat, 2 parts of good vine, 3 parts of chicken bone firewood, 2 parts of ground cucumber, 4 parts of flowered bamboo, 1 part of prickly lotus, 3 parts of ground bitter gall, 2 parts of paulownia flower, 4 parts of black peach flower, 1 part of nightshade, 3 parts of white kema leaf, 2 parts of daqu, 3 parts of wine koji flower, 2 parts of yellow quail grass, 3 parts of aged wormwood, 2 parts of hollow grass and 3 parts of money grass.

5. A Chinese herbal medicine combination prescription for treating human calculi according to claim 1, characterized in that: The invention is made from the following raw materials in parts by weight: 2 parts of large tongcao, 2 parts of small tongcao, 3 parts of mountain loquat, 3 parts of good vine, 2 parts of chicken bone firewood, 3 parts of ground cucumber, 3 parts of flowered bamboo, 2 parts of prickly lotus, 2 parts of ground bitter gall, 3 parts of paulownia flower, 3 parts of black peach flower, 2 parts of nightshade, 2 parts of white kema leaf, 3 parts of daqu, 3 parts of wine koji flower, 3 parts of yellow quail grass, 2 parts of aged wormwood, 3 parts of hollow grass, and 2 parts of money grass.

6. A Chinese herbal medicine combination prescription for treating human calculi according to claim 1, characterized in that: The invention is made from the following raw materials in parts by weight: 3 parts of large tongcao, 3 parts of small tongcao, 3 parts of mountain loquat, 3 parts of good vine, 2 parts of chicken bone firewood, 3 parts of ground cucumber, 3 parts of flowered bamboo, 2 parts of prickly lotus, 2 parts of ground bitter gall, 3 parts of paulownia flower, 3 parts of black peach flower, 3 parts of nightshade, 2 parts of white kema leaf, 3 parts of daqu, 2 parts of wine koji flower, 3 parts of yellow quail grass, 2 parts of aged wormwood, 3 parts of hollow grass, and 3 parts of money grass.

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