Umbilical region support material after umbilical region reconstruction and preparation method and application thereof

Abstract

The invention discloses an umbilical region support material after umbilical region reconstruction as well as a preparation method and application thereof, the umbilical region support material after umbilical region reconstruction in abdominal wall shaping comprises the following components in percentage by weight: 30-55% of EVA (Ethylene Vinyl Acetate) resin, 20-40% of terpene resin, 20-30% of paraffin and 1-3% of antioxidant, and the softening temperature of the umbilical region support material after umbilical region reconstruction is 60-80 DEG C. The preparation method of the umbilical region support material after umbilical region reconstruction in abdominal wall reshaping comprises the following steps: mixing EVA resin with terpene resin, paraffin and an antioxidant according to a formula, melting at 150-180 DEG C, and uniformly stirring. The material provided by the invention can maintain the shape of a new navel after the navel reconstruction operation, and is beneficial to adhesion of navel skin and deep tissues so as to prevent the navel from protruding; and moreover, avascular necrosis of the umbilical flap cannot be caused.

Description

Technical Field

[0001] The invention relates to a umbilical support material after umbilical reconstruction, and in particular to a umbilical support material after umbilical reconstruction and a preparation method and application thereof. Background Art

[0002] Abdominal wall plastic surgery is a general term for the unsightly shape of the abdominal wall caused by loose skin and fat accumulation, and loose muscle fascia system of the abdominal wall. The unsightly shape is corrected through surgical methods to restore the youthful and beautiful curves of the abdominal wall. This type of surgery is collectively called abdominal wall plastic surgery. Navel reconstruction surgery is to make a cross-shaped incision in the navel through surgery, secretly separate the skin flap, reshape the umbilicus in the deep part, and fix and suture it with the rectus abdominis sheath to achieve the plastic surgery purpose.

[0003] In abdominoplasty, the reconstruction of the umbilicus is one of the key links. According to the aesthetic requirements, the umbilicus needs to be reconstructed into a new umbilicus with a depth of 0.5-1.8cm and a round or oval appearance. After the umbilicus is reconstructed, the new umbilicus needs to be filled so that the various flaps of the new umbilicus can be stably attached to the abdominal wall tissue. Oil gauze is currently commonly used in clinical practice, but oil gauze is relatively soft. Since the rectus abdominis muscle is folded at the same time during abdominoplasty, the intra-abdominal pressure increases, which can easily lead to a bulging umbilicus. It will be difficult to maintain the shape of the new umbilicus, and it may even cause a bulging umbilicus.

[0004] Therefore, it is necessary to design a device that can maintain the new umbilical shape and will not cause ischemia and necrosis of the umbilical flap. Summary of the invention

[0005] In view of the above technical problems, the present invention provides an umbilical support material after umbilical reconstruction in abdominal wall plastic surgery, and a preparation method and application thereof. The material provided by the present invention can maintain the new umbilical shape after umbilical reconstruction and facilitate the adhesion of the umbilical skin and deep tissue to prevent the umbilical bulge; and has a certain degree of deformability and will not cause ischemia and necrosis of the umbilical flap.

[0006] To achieve the above object, the technical solution of the present invention is:

[0007] A umbilical support material for umbilical reconstruction in abdominal wall plastic surgery, comprising 30-55% EVA resin, 20-35% terpene resin, 20-30% paraffin and 1-3% antioxidant in parts by weight.

[0008] The softening temperature of the umbilical support material after umbilical reconstruction is 60-80°C.

[0009] Preferably, the molecular weight of the EVA resin is 1-5wDd, and the molecular weight of the terpene resin is 1-4kDd. The larger the molecular weight of the EVA resin, the higher its elastic modulus. The higher the elastic modulus, the higher the hardness of the EVA resin. Limiting the molecular weight of the EVA resin to 1-5wDd can ensure the strength of the support material after hardening so that it can support and maintain the shape of the umbilicus. The molecular weight of the terpene resin is related to its softening temperature. The larger the molecular weight of the terpene resin, the higher its softening temperature. Limiting the molecular weight of the terpene resin to 1-4kDd and compounding it with paraffin can adjust the softening temperature to a temperature that is easily accessible to clinicians - 60-80°C.

[0010] Preferably, the molecular weight of the EVA resin is 2wDd, and the molecular weight of the terpene resin is 4kDd, or the molecular weight of the EVA resin is 5wDd, and the molecular weight of the terpene resin is 3kDd, or the molecular weight of the EVA resin is 2wDd, and the molecular weight of the terpene resin is 1kDd.

[0011] Preferably, the composition comprises 30% EVA resin, 38% terpene resin, 30% paraffin wax and 2% antioxidant in parts by weight.

[0012] Preferably, the composition comprises 55% EVA resin, 20% terpene resin, 22% paraffin wax and 3% antioxidant in parts by weight.

[0013] Preferably, the composition comprises 45% EVA resin, 28% terpene resin, 25% paraffin wax and 2% antioxidant in parts by weight.

[0014] Preferably, the antioxidant is BHT antioxidant or ascorbic acid.

[0015] Based on the same inventive concept, the present invention also provides a method for preparing the above-mentioned umbilical support material after umbilical reconstruction, comprising mixing EVA resin with terpene resin, paraffin wax and antioxidant according to a formula, melting at 150-180° C. and stirring evenly.

[0016] Based on the same inventive concept, the present invention also provides the use of the above-mentioned umbilical support material after umbilical reconstruction in maintaining and supporting the shape of the umbilicus after umbilical reconstruction, especially after umbilical reconstruction in abdominal wall plastic surgery or umbilical reconstruction for treating umbilical hernia, the material is reshaped into different shapes and filled into the reconstructed umbilicus to support the shape of the umbilicus, so that the various skin flaps of the new umbilicus are stably attached to the abdominal wall tissue and the umbilicus is raised.

[0017] Due to the adoption of the above technical solution, the present invention has the following advantages and positive effects compared with the prior art:

[0018] The material provided by the present invention includes EVA resin, terpene resin, paraffin and antioxidant. Based on EVA resin and terpene resin thermal deformation materials, the softening temperature of paraffin thermal deformation materials is added, so that the material can be softened at a temperature that can be easily obtained by clinicians during surgery, so that the material can be deformed at will, matching the shape of the patient's navel, and meeting personalized needs; at the same time, it solidifies and hardens near body temperature. Since EVA resin can provide strength and terpene resin can provide hardness, the material provides support for the navel after solidification and hardening to maintain the shape of the reconstructed navel, so that each flap of the new navel is stably attached to the abdominal wall tissue, and it also has a certain elasticity after solidification and hardening, and will not cause discomfort to the patient. In addition, since antioxidants are added to the material of the present invention, the material will not damage the skin, especially the navel flap. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 The photographs are of the umbilical support material before and after softening and personalized plasticity after umbilical reconstruction in the abdominal wall plastic surgery of the present invention;

[0020] Figure 2 This is a diagram showing the cytotoxicity test results of the material prepared in Example 1 of the present invention;

[0021] Figure 3 This is a graph showing the mechanical properties of the material prepared in Example 1 of the present invention;

[0022] Figure 4 This is a mechanical property test diagram of the oil gauze in the present invention;

[0023] Figure 5 This is a diagram showing the cytotoxicity test results of the material prepared in Example 2 of the present invention;

[0024] Figure 6 This is a graph showing the mechanical properties of the material prepared in Example 2 of the present invention;

[0025] Figure 7 This is a diagram showing the cytotoxicity test results of the material prepared in Example 3 of the present invention;

[0026] Figure 8 This is a graph showing the mechanical properties of the material prepared in Example 3 of the present invention. DETAILED DESCRIPTION

[0027] The present invention aims to maintain the shape of the navel after navel reconstruction surgery, and proposes a navel support material after navel reconstruction. During the operation, the material is placed in 60-80℃ hot water. The material can be arbitrarily plasticized (for example, Figure 1The left picture shows the material before softening, and the right picture shows the shape of the reconstructed navel after softening). Then the material that is shaped according to the patient's navel is placed on the patient's navel. The material solidifies at room temperature or body temperature, providing support for the navel and will not be easily deformed by the movement of nearby skin tissue. In addition, it not only provides support in the early stage of navel reconstruction surgery, but also facilitates the adhesion of the navel flap and deep tissue to prevent the navel from bulging.

[0028] The following is a further detailed description of the umbilical support material for umbilical reconstruction in abdominal wall plastic surgery and its preparation method and application in conjunction with the accompanying drawings and specific embodiments. The advantages and features of the present invention will become more apparent from the following description.

[0029] Example 1

[0030] The umbilical support material after umbilical reconstruction includes: 45% EVA resin, 28% terpene resin, 25% paraffin and 2% BHT antioxidant (tert-butyl p-cresol).

[0031] The molecular weight of EVA resin is 2wDd, the molecular weight of terpene resin is 4kDd, and the softening temperature of the umbilical support material is 60 degrees Celsius.

[0032] The preparation method comprises: mixing 45% EVA resin, 28% terpene resin, 25% paraffin and 2% antioxidant, melting at 180° C. and stirring evenly.

[0033] 1. Perform MTT test on the prepared materials for cell vesicle toxicity

[0034] Human skin-derived fibroblasts were cultured in vitro and then inoculated into 96-well cell culture medium, with 3,000 cells per well. The control group only added 10% FBS / DMEM culture medium, and the experimental group added material + 10% FBS / DMEM culture medium. At 24h, 48h, and 72h after adding the material, 20μl of MTT solution (5mg / ml, Sigma) was added to each culture well. After incubation for 4 hours, 100μl of DMSO solution was added to each well, shaken and mixed to dissolve, and the absorbance value of each well was measured in an enzyme-linked immunosorbent assay instrument at OD570. The test results are as follows Figure 2 As shown, from Figure 2 It can be seen that there is almost no difference in the absorbance values ​​between the experimental group and the control group within 42 hours, and there is some difference between 48 hours and 72 hours, but the difference is not significant, which further indicates that the material prepared in Example 1 has no cytotoxicity.

[0035] 2. Test the mechanical properties of the prepared materials by compression cycle

[0036] The material and the oil yarn are compressed and cycled, and the oil yarn is rolled up layer by layer with the same volume as the material. Figure 3The loading process of the subsequent loop is demonstrated. Under the same deformation distance (0-2mm), the compression force required for the material is 230.4N, which is much larger than the compression force required for the oil yarn, 2.3N, indicating that the material has better support.

[0037] Example 2

[0038] The umbilical support material after umbilical reconstruction includes: 30% EVA resin, 38% terpene resin, 30% paraffin and 2% antioxidant (ascorbic acid).

[0039] The molecular weight of the EVA resin is 5wDd, the molecular weight of the terpene resin is 3kDd, and the softening temperature of the umbilical support material is 70 degrees Celsius.

[0040] 1. Perform MTT test on the prepared materials for cell vesicle toxicity

[0041] Human skin-derived fibroblasts were cultured in vitro and then inoculated into 96-well cell culture medium, with 3,000 cells per well. The control group only added 10% FBS / DMEM culture medium, and the experimental group added material + 10% FBS / DMEM culture medium. At 24h, 48h, and 72h after adding the material, 20μl of MTT solution (5mg / ml, Sigma) was added to each culture well. After incubation for 4 hours, 100μl of DMSO solution was added to each well, shaken and mixed to dissolve, and the absorbance value of each well was measured in an enzyme-linked immunosorbent assay instrument at OD570. The test results are as follows Figure 5 As shown, from Figure 5 It can be seen that the absorbance values ​​of the experimental group and the control group have a slight difference around 42h, but the difference is not large. The absorbance values ​​of other experimental groups coincide with the experimental group, which further indicates that the material prepared in Example 2 has no cytotoxicity.

[0042] 2. Test the mechanical properties of the prepared materials by compression cycle

[0043] The material is compressed and cycled. Figure 6 The loading process of the subsequent loop is demonstrated. Under the same deformation distance (0-2mm), the compression force required for the material is 232.1N, which is much larger than the compression force required for the oil yarn, 2.3N, indicating that the material has better support.

[0044] Example 3

[0045] The umbilical support material after umbilical reconstruction includes: 55% EVA resin, 20% terpene resin, 22% paraffin and 3% antioxidant (ascorbic acid).

[0046] The molecular weight of the EVA resin is 2wDd, the molecular weight of the terpene resin is 1kDd, and the softening temperature of the umbilical support material is 65 degrees Celsius.

[0047] 1. Perform MTT test on the prepared materials for cell vesicle toxicity

[0048] Human skin-derived fibroblasts were cultured in vitro and then inoculated into 96-well cell culture medium, with 3,000 cells per well. The experimental group was material + 10% FBS / DMEM culture medium. 20 μl of MTT solution (5 mg / ml, Sigma) was added to each culture well at 24h, 48h, and 72h after adding the material. After incubation for 4 hours, 100 μl of DMSO solution was added to each well, shaken and mixed to dissolve, and the absorbance of each well was measured in an enzyme-linked immunosorbent assay instrument at OD570. The test results are as follows: Figure 7 As shown, from Figure 7 It can be seen that there is almost no difference in the absorbance values ​​between the experimental group and the control group within 42 hours, and there is some difference between 48 hours and 72 hours, but the difference is not significant, which further indicates that the material prepared in Example 3 has no cytotoxicity.

[0049] 2. Test the mechanical properties of the prepared materials by compression cycle

[0050] The material is compressed and cycled. Figure 8 The loading process of the subsequent loop is demonstrated. Under the same deformation distance (0-2mm), the compression force required for the material is 229.4N, which is much larger than the compression force required for the oil yarn, 2.3N, indicating that the material has better support.

[0051] Through the explanation of the above embodiments, the umbilical support material after umbilical reconstruction provided by the present invention can be softened at a temperature that is easy for clinicians to operate, and then can be arbitrarily plasticized according to the shape of the patient's umbilicus. The hardened material has good supporting force, which is far greater than the oil gauze commonly used in clinical practice. It can provide good support for the reconstructed umbilicus, has no cytotoxicity, and can be arbitrarily plasticized according to the patient's individual needs.

[0052] Therefore, the umbilical support material provided by the present invention can not only be used for supporting and maintaining the umbilical cord after umbilical cord reconstruction in abdominal wall plastic surgery, but can also be used for supporting and maintaining the umbilical cord after other treatments requiring umbilical cord reconstruction, such as umbilical hernia.

[0053] The embodiments of the present invention are described in detail above in conjunction with the accompanying drawings, but the present invention is not limited to the above embodiments. Even if various changes are made to the present invention, if these changes fall within the scope of the claims of the present invention and their equivalents, they still fall within the protection scope of the present invention.

Claims

1. A umbilical support material for umbilical reconstruction in abdominal wall plastic surgery, characterized in that: According to the weight percentage, it includes 30-55% EVA resin, 20-40% terpene resin, 20-30% paraffin and 1-3% antioxidant. The softening temperature of the umbilical support material after umbilical reconstruction is 60-80°C.

2. The umbilical support material after umbilical reconstruction according to claim 1, characterized in that: The molecular weight of the EVA resin is 1-5wDd, and the molecular weight of the terpene resin is 1-4kDd.

3. The umbilical support material after umbilical reconstruction according to claim 2, characterized in that: The molecular weight of the EVA resin is 2wDd, and the molecular weight of the terpene resin is 4kDd, or the molecular weight of the EVA resin is 5wDd, and the molecular weight of the terpene resin is 3kDd, or the molecular weight of the EVA resin is 2wDd, and the molecular weight of the terpene resin is 1kDd.

4. The umbilical support material after umbilical reconstruction according to claim 1, characterized in that: The invention comprises 45% of EVA resin, 28% of terpene resin, 25% of paraffin wax and 2% of antioxidant according to weight.

5. The umbilical support material after umbilical reconstruction according to claim 1, characterized in that: The invention comprises 30% of EVA resin, 38% of terpene resin, 30% of paraffin wax and 2% of antioxidant according to weight.

6. The umbilical support material after umbilical reconstruction according to claim 1, characterized in that: The invention comprises 55% of EVA resin, 20% of terpene resin, 22% of paraffin wax and 3% of antioxidant according to weight.

7. The umbilical support material after umbilical reconstruction according to claim 1, characterized in that: The antioxidant is BHT antioxidant or ascorbic acid.

8. A method for preparing the umbilical support material after umbilical reconstruction according to any one of claims 1 to 7, characterized in that: The method comprises mixing EVA resin, terpene resin, paraffin wax and antioxidant according to a formula, melting at 150-180 DEG C and then stirring evenly.

9. Use of the umbilical support material after umbilical reconstruction according to any one of claims 1 to 7 in maintaining and supporting the shape of the umbilical cord after umbilical cord reconstruction.

10. Use of the umbilical support material after umbilical reconstruction as claimed in any one of claims 1 to 7 in maintaining and supporting the shape of the umbilicus after umbilical reconstruction in abdominal wall plastic surgery or umbilical hernia.

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