Multi-channel phase resonance transcranial ultrasonic regulation and control system and method based on 3D printing

Abstract

The invention discloses a multi-channel phase resonance transcranial ultrasonic regulation and control system and method based on 3D printing, and relates to the technical field of transcranial ultrasonic nerve regulation and control. Firstly, after three-dimensional modeling is conducted on the basis of patient head diagnosis and treatment data obtained in advance, a brain region needing to be stimulated is calibrated; then, on the basis of the acoustic theory, calculating a spatial position and an angle corresponding to the ultrasonic stimulation probe by applying an inversion technology; according to the calculation result, a personalized 3D printing helmet is designed, and a structure used for fixing an ultrasonic probe is printed on the top of the helmet; the device for fixing the ultrasonic stimulation probe adopts a special design, and the distance between the probe and the surface of a skull can be adjusted; the ultrasonic stimulation probe is composed of multiple channels and multiple array elements and can achieve phase resonance and adjust the focus position. Due to the fact that millimeter-level deviation exists in the system, a large amount of data are collected, an artificial intelligence model is established, modeling is conducted on 3D printing helmet system errors, after accurate errors are obtained, the focus position is further adjusted through the ultrasonic phase resonance technology, and accurate positioning is achieved.

Description

[0001] The present invention relates to the technical field of transcranial ultrasonic nerve regulation, and in particular to a multi-channel phase resonance transcranial ultrasonic regulation system and method based on 3D printing. Background Art

[0002] Transcranial ultrasound precision neuromodulation technology is a new, non-invasive neuromodulation technology with great development prospects in brain science research and brain disease treatment. Studies have shown that ultrasound stimulation with different parameters can excite or inhibit neuronal activity, stimulate ion channel opening, activate nerve conduction loops, and regulate protein expression levels. This system integrates multiple disciplines such as ultrasound, neuroscience, and medical engineering. It uses three-dimensional reconstruction of data after modeling of diagnostic and therapeutic scan data such as skull CT and nuclear magnetic resonance, and achieves precise positioning by making customized helmets. Ultrasound control technology has achieved precise targeted positioning treatment and control purposes. Neuromodulation technology is a reversible treatment method based on implantable or non-implantable technology that uses electrical stimulation or other physical means to change the activity of the central nervous system, peripheral nervous system, or autonomic nervous system, thereby improving the symptoms of the patient. In recent years, deep brain stimulation technology for the treatment of Parkinson's disease, dystonia, and obsessive-compulsive disorder, vagus nerve stimulation technology for epilepsy and depression, and repetitive transcranial magnetic stimulation technology for the treatment of depression have been promoted to clinical applications. Neuroregulation is increasingly closely related to clinical research. However, these neuroregulatory technologies all have corresponding inevitable disadvantages: deep brain stimulation requires surgical implantation of electrodes, which is expensive and requires cumbersome subsequent maintenance; transcranial direct current stimulation and transcranial magnetic stimulation are both non-invasive technologies, but have low spatial resolution and cannot reach deep target areas; optogenetics uses lasers of different wavelengths to achieve excitatory or inhibitory regulation at the cellular level, and has high spatial resolution and cell specificity, but optogenetics requires surgical operations involving viral transcription or transgenics and has not yet been approved for clinical use.

[0003] However, there are some problems with traditional transcranial ultrasound neuromodulation technology:

[0004] 1. First, traditional transcranial ultrasound neuromodulation technology usually uses nuclear magnetic resonance for navigation and positioning. However, the magnetic navigation system is expensive and requires manual operation by experienced doctors. Only large tertiary hospitals are able to provide such a system, and the treatment costs for patients are also high.

[0005] 2. Traditional transcranial ultrasound neuromodulation has large errors due to manual operation and cannot achieve long-term treatment, which in turn affects the effect of transcranial ultrasound neuromodulation.

[0006] Based on the above problems, the present invention proposes a multi-channel phase resonance transcranial focused ultrasound precise neural regulation system based on a personalized 3D printed helmet. Summary of the invention

[0007] The purpose of the present invention is to provide a multi-channel phase resonance transcranial ultrasound control system and method based on 3D printing to solve the problems raised in the prior art.

[0008] To achieve the above-mentioned purpose, the present invention provides the following technical solutions: a multi-channel phase resonance transcranial ultrasound regulation system based on 3D printing, comprising a three-dimensional modeling and brain area calibration module, an ultrasound stimulation probe calculation and design module, an ultrasound stimulation probe module, an error modeling and adjustment module and a human-computer interaction module; the three-dimensional modeling and brain area calibration module is used to read image data, construct a three-dimensional model, and perform brain area calibration; the ultrasound stimulation probe calculation and design module is used to calculate the spatial position and angle corresponding to the ultrasound stimulation probe, and design a personalized 3D printed helmet, and then adjust the distance between the probe and the skull surface; the ultrasound stimulation probe module is used to use phase resonance to improve the energy and effect of ultrasound stimulation, and adjust the focal position of ultrasound stimulation; the error modeling and adjustment module is used to collect a large amount of real-time data after the 3D printed helmet system is worn, model and analyze the error, and further adjust the focal position through ultrasound phase resonance technology; the human-computer interaction module is used to formulate and save treatment plans, and update the plans through an operation panel.

[0009] The three-dimensional modeling and brain area calibration module further includes an image data reading unit, a three-dimensional modeling unit and a brain area calibration unit; the image data reading unit is used to read the user's diagnostic scanning image data; the three-dimensional modeling unit is used to process the acquired head image data to construct a three-dimensional model of the user's head; the brain area calibration unit is used to calibrate the brain area that needs ultrasonic stimulation according to a given medical plan.

[0010] The ultrasound stimulation probe calculation and design module further includes an inversion calculation unit, a helmet design unit and a probe adjustment unit; the inversion calculation unit is used to calculate the spatial position and angle corresponding to the ultrasound stimulation probe according to the calibrated brain area position using inversion technology;

[0011] The helmet design unit is used to design a personalized 3D printed helmet according to the calculated spatial coordinates and angles of the ultrasonic stimulation probe; the helmet comprises a chassis part, a probe part, a fixture part, a host computer software part and a slave computer software part, and the chassis part has a touch screen, a PCBA, a switching power supply, a power supply interface, a switch, and an indicator light;

[0012] The touch screen contains the lower computer software, which is used to display and set relevant treatment parameters; PCBA is used to control the entire system and drive the probe; the switching power supply converts the external AC220V into DC power, which is used for the total power input of PCBA. The power supply interface serves as the AC220V input interface of the system to introduce the external power supply into the system. The switch is used to control the input of the total power supply of the system, which is convenient for powering on and off the equipment. The indicator light is used to indicate the operating status of the system. It lights up when the equipment is powered on and goes out when the equipment is powered off.

[0013] The ultrasonic treatment probe can be equipped with different center frequency probes for nerve regulation according to different application scenarios; the ultrasonic treatment head is composed of multiple array elements / channels, which can achieve phase resonance focusing. Since the phase resonance adopts the principle of delaying the occurrence of different channels to adjust the focus position, the phase resonance technology used in the present invention can realize the free adjustment of the focus, greatly reducing the time and cost of traditional methods;

[0014] The fixing device part fixes the ultrasonic treatment probe through the helmet body and other mechanical parts, and the head, whose inner wall matches and fits with the surface of the patient's head; a treatment head embedding structure is arranged at several predetermined positions of the helmet body, and several treatment heads are detachably fixed and embedded on the helmet body, so that the treatment end of the treatment head matches and fits the designated part of the patient's head. The fixing device is a 3D printed head cover, which automatically calculates the position of the ultrasonic probe according to the pre-set brain area, including the distance from the scalp, angle and other parameters, and automatically prints a personalized helmet according to these parameters;

[0015] The upper computer software is used for preoperative positioning. The diagnostic scan data uploaded by the user is processed by inversion calculation to obtain the location of the treatment head embedding structure.

[0016] The function of the lower computer is to drive the ultrasonic probe, set the ultrasonic power, and provide two ultrasonic output modes: continuous and pulsed. In the continuous output mode, the excitation signal of the ultrasonic probe will be continuously sent out. In the pulse output mode, the excitation signal of the ultrasonic probe will be sent out in pulses with a set frequency duty cycle. The ultrasonic power is mainly achieved by adjusting the voltage duty cycle of the excitation pulse. The excitation required by the ultrasonic probe is mainly provided by the half-bridge driver chip. Since the chip is equivalent to an H-bridge, the waveform required to drive this chip is provided by the complementary output function of the STM32 advanced timer with dead zone control. The control of the ultrasonic mode is achieved through the brake input function of the above function. Each advanced timer of the STM32 has a brake input channel corresponding to different pins. When the pin input is valid, the PWM output of the timer will stop. Therefore, the pulse output mode of the ultrasonic probe can be realized by connecting the PWM output of another timer to the brake input pin of the advanced timer. The duty cycle of the ultrasonic probe output can be controlled by changing the PWM duty cycle. When the duty cycle is 100%, the output mode is continuous output.

[0017] The probe adjustment unit is responsible for enabling the device for fixing the ultrasonic stimulation probe to adjust the distance between the probe and the skull surface.

[0018] The ultrasound stimulation probe module further includes a multi-channel multi-element probe working unit and a focal position adjustment unit; the multi-channel multi-element probe working unit is used to adjust the energy and effect of ultrasound stimulation through phase resonance technology, and set the initial position of the ultrasound stimulation focus by controlling the signal transmission of different channels and array elements; the focal position adjustment unit adjusts the focal position of ultrasound stimulation according to treatment needs and brain area position.

[0019] The error modeling and adjustment module further includes a data acquisition unit, an artificial intelligence modeling unit and an error correction unit; the data acquisition unit is used to collect a large amount of real-time data of the 3D printed helmet system after being worn; the artificial intelligence modeling unit is used to use the collected data to establish an artificial intelligence model to analyze the errors of the 3D printed helmet system; the error correction unit is used to further adjust the focus position through ultrasonic phase resonance technology after obtaining accurate error information.

[0020] The scheme formulation unit is used to customize, set and save treatment schemes through the UI of the serial port screen. Users do not need to set parameters again when performing the same type of treatment again. When selecting a scheme, Scheme 1 is displayed at the beginning, and there is a new function under Scheme 1 to add a new scheme. Each scheme can be edited and used. When editing, it jumps to the mode selection page. After selecting continuous or pulse mode, it jumps to the parameter setting page. The parameter setting page can be used to set parameters such as frequency, modulation frequency, modulation duty cycle, duration, single modulation cycle time, single modulation cycle effective time, voltage, etc.

[0021] The working implementation of the human-computer interaction page is based on the combination of the upper computer and the lower computer. The working principle is that the lower computer software uses the serial port screen to provide the human-computer interaction interface, and confirms the received frame and sends the data through the communication protocol; each frame of data consists of a packet header, a packet body, and a packet tail; the packet header is fixed to 0xEE, the packet tail is fixed to 0xFF, and the function of the packet is determined by the packet body; the packet sent by the upper computer to the lower computer is a system parameter packet and a stop instruction packet; the upper computer sets the working parameters of the lower computer through the system parameter packet, and enables the lower computer to start ultrasonic treatment, and notifies the lower computer to stop ultrasonic treatment through the stop instruction packet. After the lower computer receives the data packet from the upper computer, it should return an ACK packet to indicate that the data has been received;

[0022] The ultrasound output unit is used to display the currently selected treatment plan on the home page after the plan is clicked for use. When clicking on output, there is a confirmation box prompting whether to confirm the ultrasound output. In addition, when clicking on output, if there is a problem with the device and it cannot output, the device will be reminded that an error has occurred.

[0023] To achieve the above object, the present invention provides the following technical solution: a multi-channel phase resonance transcranial ultrasound control method based on 3D printing, comprising the following steps:

[0024] S1. Read the user's diagnostic imaging data, build a three-dimensional model, and calibrate the brain area to be treated;

[0025] S2. Calculate the spatial position and angle of the ultrasound stimulation probe according to the calibrated brain area position, design a personalized 3D printed helmet, and then adjust the distance between the probe and the skull surface;

[0026] S3. After the helmet is manufactured, phase resonance technology is used to adjust the energy and effect of ultrasound stimulation according to the diagnosis and treatment results of the user, and the focal position of ultrasound stimulation is adjusted at the same time;

[0027] S4. After the treatment, a large amount of real-time data of the 3D printed helmet system is collected, the error is modeled and analyzed, and the focus position is further adjusted through ultrasonic phase resonance technology;

[0028] S5. After the error adjustment is completed, the treatment plan is saved through the human-computer interaction panel, and the treatment plan can be adjusted as needed later.

[0029] The reading of the user's diagnostic imaging data, construction of a three-dimensional model, and calibration of the brain region to be treated further include the following contents: first, reading the user's diagnostic scanning imaging data, then processing the acquired head imaging data, and constructing a three-dimensional model of the user's head; and finally, calibrating the brain region to be treated with ultrasound according to the given medical plan.

[0030] The method further includes the following steps: calculating the spatial position and angle of the ultrasound stimulation probe according to the calibrated brain region position, designing a personalized 3D printed helmet, and then adjusting the distance between the probe and the skull surface:

[0031] First, the inversion technology is used to calculate the spatial position and angle of the ultrasound stimulation probe according to the calibrated brain area position; then, a personalized 3D printed helmet is designed based on the calculated spatial coordinates and angle of the ultrasound stimulation probe; the helmet consists of a chassis part, a probe part, a fixture part, a host computer software part and a slave computer software part. The chassis part has a touch screen, PCBA, a switching power supply, a power supply interface, a switch, and an indicator light;

[0032] The touch screen contains the lower computer software, which is used to display and set relevant treatment parameters; PCBA is used to control the entire system and drive the probe; the switching power supply converts the external AC220V into DC power, which is used for the total power input of PCBA. The power supply interface serves as the AC220V input interface of the system to introduce the external power supply into the system. The switch is used to control the input of the total power supply of the system, which is convenient for powering on and off the equipment. The indicator light is used to indicate the operating status of the system. It lights up when the equipment is powered on and goes out when the equipment is powered off.

[0033] The ultrasonic treatment probe can be equipped with different center frequency probes for nerve regulation according to different application scenarios; the ultrasonic treatment head is composed of multiple array elements / channels, which can achieve phase resonance focusing. Since the phase resonance adopts the principle of delaying the occurrence of different channels to adjust the focus position, the phase resonance technology used in the present invention can realize the free adjustment of the focus, greatly reducing the time and cost of traditional methods;

[0034] The fixing device part fixes the ultrasonic treatment probe through the helmet body and other mechanical parts, and the head, whose inner wall matches and fits with the surface of the patient's head; a treatment head embedding structure is arranged at several predetermined positions of the helmet body, and several treatment heads are detachably fixed and embedded on the helmet body, so that the treatment end of the treatment head matches and fits the designated part of the patient's head. The fixing device is a 3D printed head cover, which automatically calculates the position of the ultrasonic probe according to the pre-set brain area, including the distance from the scalp, angle and other parameters, and automatically prints a personalized helmet according to these parameters;

[0035] The upper computer software is used for preoperative positioning. The diagnostic scan data uploaded by the user is processed by inversion calculation to obtain the location of the treatment head embedding structure.

[0036] The function of the lower computer is to drive the ultrasonic probe, set the ultrasonic power, and provide two ultrasonic output modes: continuous and pulsed. In the continuous output mode, the excitation signal of the ultrasonic probe will be continuously sent out. In the pulse output mode, the excitation signal of the ultrasonic probe will be sent out in pulses with a set frequency duty cycle. The ultrasonic power is mainly achieved by adjusting the voltage duty cycle of the excitation pulse. The excitation required by the ultrasonic probe is mainly provided by the half-bridge driver chip. Since the chip is equivalent to an H-bridge, the waveform required to drive this chip is provided by the complementary output function of the STM32 advanced timer with dead zone control. The control of the ultrasonic mode is achieved through the brake input function of the above function. Each advanced timer of the STM32 has a brake input channel corresponding to different pins. When the pin input is valid, the PWM output of the timer will stop. Therefore, the pulse output mode of the ultrasonic probe can be realized by connecting the PWM output of another timer to the brake input pin of the advanced timer. The duty cycle of the ultrasonic probe output can be controlled by changing the PWM duty cycle. When the duty cycle is 100%, the output mode is continuous output.

[0037] Finally, the device for fixing the ultrasound stimulation probe is used to adjust the distance between the probe and the skull surface according to the helmet design results and the user's diagnosis and treatment plan;

[0038] After the helmet is manufactured, the phase resonance technology is used to adjust the energy and effect of the ultrasound stimulation according to the diagnosis and treatment results of the user, and the focal position of the ultrasound stimulation is further adjusted, including the following:

[0039] First, the energy and effect of ultrasound stimulation are adjusted through phase resonance technology, and the initial position of the ultrasound stimulation focus is set by controlling the signal transmission of different channels and array elements; then, the focal position of ultrasound stimulation is adjusted according to treatment needs and brain area location.

[0040] The collecting of a large amount of real-time data of the 3D printed helmet system after wearing, modeling and analyzing the error, and further adjusting the focus position by ultrasonic phase resonance technology further include the following contents:

[0041] First, a large amount of real-time data of the 3D printed helmet system after wearing is collected, and then an artificial intelligence model is established to analyze the error of the 3D printed helmet system. After obtaining the error results, the ultrasound phase resonance technology is used to further adjust the focal position that meets the treatment requirements according to the user's diagnosis and treatment results.

[0042] After the error adjustment is completed, the treatment plan is saved through the human-computer interaction panel, and the treatment plan can be adjusted as needed later to further include the following contents:

[0043] After the helmet is customized, the user can customize, set and save the treatment plan through the UI of the serial port screen through the prescription, and there is no need to repeat the parameter setting when the same type of treatment is carried out again; when selecting the plan, Plan 1 is displayed at the beginning, and there is a new function under Plan 1 to add a new plan; each plan can be edited and used, and the page for mode selection is jumped when editing. After selecting continuous or pulse mode, it jumps to the parameter setting page; the parameter setting page can be used to set parameters such as frequency, modulation frequency, modulation duty cycle, duration, single modulation cycle time, single modulation cycle effective time, voltage, etc.

[0044] The working implementation of the human-computer interaction page is based on the combination of the upper computer and the lower computer. The working principle is that the lower computer software uses the serial port screen to provide the human-computer interaction interface, and confirms the received frame and sends the data through the communication protocol; each frame of data consists of a packet header, a packet body, and a packet tail; the packet header is fixed to 0xEE, the packet tail is fixed to 0xFF, and the function of the packet is determined by the packet body; the packet sent by the upper computer to the lower computer is a system parameter packet and a stop instruction packet; the upper computer sets the working parameters of the lower computer through the system parameter packet, and enables the lower computer to start ultrasonic treatment, and notifies the lower computer to stop ultrasonic treatment through the stop instruction packet. After the lower computer receives the data packet from the upper computer, it should return an ACK packet to indicate that the data has been received;

[0045] After clicking on the plan, the home page shows the currently selected treatment plan. When you click on output, there will be a confirmation box prompting you whether to confirm the ultrasound output. In addition, when you click on output, if there is a problem with the device and it cannot output, the device will be reminded that there is an error.

[0046] Compared with the prior art, the present invention has the following beneficial effects:

[0047] 1. Use customized helmets, including helmets made by 3D printing or other methods, to improve positioning accuracy:

[0048] In the production of precise TUS equipment, 3D printing technology has greatly reduced the production cost of head-mounted molds. The customized helmets can replace expensive international high-end navigators to achieve precise positioning. This innovation breaks the past dependence on international high-end navigators and makes TUS technology more widely popular.

[0049] 2. Combining the helmet positioning target positioning technology with the multi-channel ultrasonic phase resonance focus fine-tuning technology improves the positioning system accuracy:

[0050] The independently developed positioning algorithm to assist the production of helmets is advanced and conducive to the precise treatment of targets. The advanced positioning system greatly reduces the system's dependence on magnetic resonance / CT imaging, making it unnecessary for the equipment to achieve magnetic resonance compatibility, and greatly reducing the equipment production cost and treatment cost. In addition, the present invention utilizes the natural advantages of ultrasonic phase resonance technology, namely electronic focusing, and fine-tuning the focus position to further improve the accuracy of the positioning system. It is like a helmet is a relatively rough positioning system, generally with millimeter-level accuracy, and further fine-tuning through phase resonance technology can achieve sub-millimeter positioning accuracy.

[0051] 3. Customized helmets are used, eliminating the need for repeated image scanning, reducing the cost of repeated treatments:

[0052] Customizing a unique helmet based on each patient's head shape and treatment needs not only improves the comfort and effectiveness of treatment, but also introduces the concept of private customization to provide patients with more personalized medical services.

[0053] 4. This positioning method reduces the equipment manufacturing cost:

[0054] Traditional mold manufacturing processes are complex and costly, while 3D printing can produce molds with complex structures quickly and at low cost. This cost advantage not only reduces the manufacturing cost of the equipment, making it affordable for more hospitals, but also enables more patients to afford the treatment costs, thereby expanding market coverage and benefiting more patients. BRIEF DESCRIPTION OF THE DRAWINGS

[0055] Figure 1 This is a system composition diagram of the multi-channel phase resonance transcranial ultrasound control system and method based on 3D printing of the present invention;

[0056] Figure 2 A schematic diagram of a humanoid helmet of the multi-channel phase resonance transcranial ultrasound control system and method based on 3D printing of the present invention;

[0057] Figure 3 This is a system software operation flow chart of the multi-channel phase resonance transcranial ultrasound control system and method based on 3D printing of the present invention;

[0058] Figure 4 This is a system workflow diagram of the multi-channel phase resonance transcranial ultrasound control system and method based on 3D printing of the present invention. DETAILED DESCRIPTION

[0059] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0060] Example: Figure 1-Figure 4 As shown, the present invention provides a technical solution, a multi-channel phase resonance transcranial ultrasound control system and method based on 3D printing;

[0061] A multi-channel phase resonance transcranial ultrasound control system based on 3D printing comprises a three-dimensional modeling and brain region calibration module, an ultrasound stimulation probe calculation and design module, an ultrasound stimulation probe module, an error modeling and adjustment module and a human-computer interaction module; the three-dimensional modeling and brain region calibration module is used to read image data, construct a three-dimensional model, and perform brain region calibration; the ultrasound stimulation probe calculation and design module is used to calculate the spatial position and angle corresponding to the ultrasound stimulation probe, and design a personalized 3D printed helmet, and then adjust the distance between the probe and the skull surface; the ultrasound stimulation probe module is used to use phase resonance to improve the energy and effect of ultrasound stimulation, and adjust the focal position of ultrasound stimulation; the error modeling and adjustment module is used to collect a large amount of real-time data after the 3D printed helmet system is worn, model and analyze the error, and further adjust the focal position through ultrasound phase resonance technology; the human-computer interaction module is used to formulate and save treatment plans, and update the plans through an operation panel.

[0062] The three-dimensional modeling and brain area calibration module further includes an image data reading unit, a three-dimensional modeling unit and a brain area calibration unit; the image data reading unit is used to read the user's diagnostic scanning image data; the three-dimensional modeling unit is used to process the acquired head image data to construct a three-dimensional model of the user's head; the brain area calibration unit is used to calibrate the brain area that needs ultrasonic stimulation according to a given medical plan.

[0063] The ultrasound stimulation probe calculation and design module further includes an inversion calculation unit, a helmet design unit and a probe adjustment unit; the inversion calculation unit is used to calculate the spatial position and angle corresponding to the ultrasound stimulation probe according to the calibrated brain area position using inversion technology;

[0064] The helmet design unit is used to design a personalized 3D printed helmet according to the calculated spatial coordinates and angles of the ultrasonic stimulation probe; the helmet comprises a chassis part, a probe part, a fixture part, a host computer software part and a slave computer software part, and the chassis part has a touch screen, a PCBA, a switching power supply, a power supply interface, a switch, and an indicator light;

[0065] The touch screen contains the lower computer software, which is used to display and set relevant treatment parameters; PCBA is used to control the entire system and drive the probe; the switching power supply converts the external AC220V into DC power, which is used for the total power input of PCBA. The power supply interface serves as the AC220V input interface of the system to introduce the external power supply into the system. The switch is used to control the input of the total power supply of the system, which is convenient for powering on and off the equipment. The indicator light is used to indicate the operating status of the system. It lights up when the equipment is powered on and goes out when the equipment is powered off.

[0066] The ultrasonic treatment probe can be equipped with different center frequency probes for nerve regulation according to different application scenarios; the ultrasonic treatment head is composed of multiple array elements / channels, which can achieve phase resonance focusing. Since the phase resonance adopts the principle of delaying the occurrence of different channels to adjust the focus position, the phase resonance technology used in the present invention can realize the free adjustment of the focus, greatly reducing the time and cost of traditional methods;

[0067] The fixing device part fixes the ultrasonic treatment probe through the helmet body and other mechanical parts, and the head, whose inner wall matches and fits with the surface of the patient's head; a treatment head embedding structure is arranged at several predetermined positions of the helmet body, and several treatment heads are detachably fixed and embedded on the helmet body, so that the treatment end of the treatment head matches and fits the designated part of the patient's head. The fixing device is a 3D printed head cover, which automatically calculates the position of the ultrasonic probe according to the pre-set brain area, including the distance from the scalp, angle and other parameters, and automatically prints a personalized helmet according to these parameters;

[0068] The upper computer software is used for preoperative positioning. The diagnostic scan data uploaded by the user is processed by inversion calculation to obtain the location of the treatment head embedding structure.

[0069] The function of the lower computer is to drive the ultrasonic probe, set the ultrasonic power, and provide two ultrasonic output modes: continuous and pulsed. In the continuous output mode, the excitation signal of the ultrasonic probe will be continuously sent out. In the pulse output mode, the excitation signal of the ultrasonic probe will be sent out in pulses with a set frequency duty cycle. The ultrasonic power is mainly achieved by adjusting the voltage duty cycle of the excitation pulse. The excitation required by the ultrasonic probe is mainly provided by the half-bridge driver chip. Since the chip is equivalent to an H-bridge, the waveform required to drive this chip is provided by the complementary output function of the STM32 advanced timer with dead zone control. The control of the ultrasonic mode is achieved through the brake input function of the above function. Each advanced timer of the STM32 has a brake input channel corresponding to different pins. When the pin input is valid, the PWM output of the timer will stop. Therefore, the pulse output mode of the ultrasonic probe can be realized by connecting the PWM output of another timer to the brake input pin of the advanced timer. The duty cycle of the ultrasonic probe output can be controlled by changing the PWM duty cycle. When the duty cycle is 100%, the output mode is continuous output.

[0070] The probe adjustment unit is responsible for enabling the device for fixing the ultrasonic stimulation probe to adjust the distance between the probe and the skull surface.

[0071] The ultrasound stimulation probe module further includes a multi-channel multi-element probe working unit and a focal position adjustment unit; the multi-channel multi-element probe working unit is used to adjust the energy and effect of ultrasound stimulation through phase resonance technology, and set the initial position of the ultrasound stimulation focus by controlling the signal transmission of different channels and array elements; the focal position adjustment unit adjusts the focal position of ultrasound stimulation according to treatment needs and brain area position.

[0072] The error modeling and adjustment module further includes a data acquisition unit, an artificial intelligence modeling unit and an error correction unit; the data acquisition unit is used to collect a large amount of real-time data of the 3D printed helmet system after being worn; the artificial intelligence modeling unit is used to use the collected data to establish an artificial intelligence model to analyze the errors of the 3D printed helmet system; the error correction unit is used to further adjust the focus position through ultrasonic phase resonance technology after obtaining accurate error information.

[0073] The scheme formulation unit is used to customize, set and save treatment schemes through the UI of the serial port screen. Users do not need to set parameters again when performing the same type of treatment again. When selecting a scheme, Scheme 1 is displayed at the beginning, and there is a new function under Scheme 1 to add a new scheme. Each scheme can be edited and used. When editing, it jumps to the mode selection page. After selecting continuous or pulse mode, it jumps to the parameter setting page. The parameter setting page can be used to set parameters such as frequency, modulation frequency, modulation duty cycle, duration, single modulation cycle time, single modulation cycle effective time, voltage, etc.

[0074] The working implementation of the human-computer interaction page is based on the combination of the upper computer and the lower computer. The working principle is that the lower computer software uses the serial port screen to provide the human-computer interaction interface, and confirms the received frame and sends the data through the communication protocol; each frame of data consists of a packet header, a packet body, and a packet tail; the packet header is fixed to 0xEE, the packet tail is fixed to 0xFF, and the function of the packet is determined by the packet body; the packet sent by the upper computer to the lower computer is a system parameter packet and a stop instruction packet; the upper computer sets the working parameters of the lower computer through the system parameter packet, and enables the lower computer to start ultrasonic treatment, and notifies the lower computer to stop ultrasonic treatment through the stop instruction packet. After the lower computer receives the data packet from the upper computer, it should return an ACK packet to indicate that the data has been received;

[0075] The ultrasound output unit is used to display the currently selected treatment plan on the home page after the plan is clicked for use. When clicking on output, there is a confirmation box prompting whether to confirm the ultrasound output. In addition, when clicking on output, if there is a problem with the device and it cannot output, the device will be reminded that an error has occurred.

[0076] According to the proposed technical solution, the multi-channel phase resonance transcranial ultrasound control method based on 3D printing includes the following steps:

[0077] S1. Read the user's diagnostic imaging data, build a three-dimensional model, and calibrate the brain area to be treated;

[0078] S2. Calculate the spatial position and angle of the ultrasound stimulation probe according to the calibrated brain area position, design a personalized 3D printed helmet, and then adjust the distance between the probe and the skull surface;

[0079] S3. After the helmet is manufactured, phase resonance technology is used to adjust the energy and effect of ultrasound stimulation according to the diagnosis and treatment results of the user, and the focal position of ultrasound stimulation is adjusted at the same time;

[0080] S4. After the treatment, a large amount of real-time data of the 3D printed helmet system is collected, the error is modeled and analyzed, and the focus position is further adjusted through ultrasonic phase resonance technology;

[0081] S5. After the error adjustment is completed, the treatment plan is saved through the human-computer interaction panel, and the treatment plan can be adjusted as needed later.

[0082] The reading of the user's diagnostic imaging data, construction of a three-dimensional model, and calibration of the brain region to be treated further include the following contents: first, reading the user's diagnostic scanning imaging data, then processing the acquired head imaging data, and constructing a three-dimensional model of the user's head; and finally, calibrating the brain region to be treated with ultrasound according to the given medical plan.

[0083] Suppose there is a user's brain CT diagnosis and treatment report, the system's data reading unit will scan and read the diagnosis and treatment report, and enter the user's head size data, and then build a three-dimensional model based on the user's head data and the location of the disease, and highlight the location of the disease to facilitate the accurate installation of the ultrasonic stimulation probe in the subsequent helmet manufacturing process.

[0084] The method further includes the following steps: calculating the spatial position and angle of the ultrasound stimulation probe according to the calibrated brain region position, designing a personalized 3D printed helmet, and then adjusting the distance between the probe and the skull surface:

[0085] First, the inversion technology is used to calculate the spatial position and angle of the ultrasound stimulation probe according to the calibrated brain area position; then, a personalized 3D printed helmet is designed based on the calculated spatial coordinates and angle of the ultrasound stimulation probe; the helmet consists of a chassis part, a probe part, a fixture part, a host computer software part and a slave computer software part. The chassis part has a touch screen, PCBA, a switching power supply, a power supply interface, a switch, and an indicator light;

[0086] The touch screen contains the lower computer software, which is used to display and set relevant treatment parameters; PCBA is used to control the entire system and drive the probe; the switching power supply converts the external AC220V into DC power, which is used for the total power input of PCBA. The power supply interface serves as the AC220V input interface of the system to introduce the external power supply into the system. The switch is used to control the input of the total power supply of the system, which is convenient for powering on and off the equipment. The indicator light is used to indicate the operating status of the system. It lights up when the equipment is powered on and goes out when the equipment is powered off.

[0087] The ultrasonic treatment probe can be equipped with different center frequency probes for nerve regulation according to different application scenarios; the ultrasonic treatment head is composed of multiple array elements / channels, which can achieve phase resonance focusing. Since the phase resonance adopts the principle of delaying the occurrence of different channels to adjust the focus position, the phase resonance technology used in the present invention can realize the free adjustment of the focus, greatly reducing the time and cost of traditional methods;

[0088] The fixing device part fixes the ultrasonic treatment probe through the helmet body and other mechanical parts, and the head, whose inner wall matches and fits with the surface of the patient's head; a treatment head embedding structure is arranged at several predetermined positions of the helmet body, and several treatment heads are detachably fixed and embedded on the helmet body, so that the treatment end of the treatment head matches and fits the designated part of the patient's head. The fixing device is a 3D printed head cover, which automatically calculates the position of the ultrasonic probe according to the pre-set brain area, including the distance from the scalp, angle and other parameters, and automatically prints a personalized helmet according to these parameters;

[0089] The upper computer software is used for preoperative positioning. The diagnostic scan data uploaded by the user is processed by inversion calculation to obtain the location of the treatment head embedding structure.

[0090] The function of the lower computer is to drive the ultrasonic probe, set the ultrasonic power, and provide two ultrasonic output modes: continuous and pulsed. In the continuous output mode, the excitation signal of the ultrasonic probe will be continuously sent out. In the pulse output mode, the excitation signal of the ultrasonic probe will be sent out in pulses with a set frequency duty cycle. The ultrasonic power is mainly achieved by adjusting the voltage duty cycle of the excitation pulse. The excitation required by the ultrasonic probe is mainly provided by the half-bridge driver chip. Since the chip is equivalent to an H-bridge, the waveform required to drive this chip is provided by the complementary output function of the STM32 advanced timer with dead zone control. The control of the ultrasonic mode is achieved through the brake input function of the above function. Each advanced timer of the STM32 has a brake input channel corresponding to different pins. When the pin input is valid, the PWM output of the timer will stop. Therefore, the pulse output mode of the ultrasonic probe can be realized by connecting the PWM output of another timer to the brake input pin of the advanced timer. The duty cycle of the ultrasonic probe output can be controlled by changing the PWM duty cycle. When the duty cycle is 100%, the output mode is continuous output.

[0091] Finally, the device for fixing the ultrasound stimulation probe is used to adjust the distance between the probe and the skull surface according to the helmet design results and the user's diagnosis and treatment plan;

[0092] After the helmet is manufactured, the phase resonance technology is used to adjust the energy and effect of the ultrasound stimulation according to the diagnosis and treatment results of the user, and the focal position of the ultrasound stimulation is further adjusted, including the following:

[0093] First, the energy and effect of ultrasound stimulation are adjusted through phase resonance technology, and the initial position of the ultrasound stimulation focus is set by controlling the signal transmission of different channels and array elements; then, the focal position of ultrasound stimulation is adjusted according to treatment needs and brain area location.

[0094] Based on the above assumptions, the user's data is obtained and the disease area is marked. Then, according to the calibrated brain area position, the inversion technology is used to calculate the spatial position and angle of the ultrasound stimulation probe, and a customized 3D printed helmet is designed for the user. The helmet consists of a chassis part, a probe part, a fixture part, a host computer software part, and a slave computer software part. The helmet composition diagram is shown in the figure below. Figure 1 As shown;

[0095] Since the application scenarios of ultrasonic therapeutic probes are different and the symptoms of each user are different, probes with different central frequencies need to be selected for neuromodulation; then, according to the marked brain area position, the upper computer software makes a positioning, sets the treatment head embedding structure at the corresponding position of the helmet, and the treatment head is detachably fixed and embedded on the helmet body, and according to the calculated space and angle corresponding to the probe, combined with the user's head data, the treatment end of the treatment head is matched to fit the designated part of the patient's head, such as Figure 2 As shown, the helmet is printed out, and the lower computer is used to drive the ultrasonic probe for preliminary treatment. As described in the above scheme, the lower computer can set the ultrasonic power and can provide two ultrasonic output modes, namely continuous and pulsed. In the continuous output mode, the excitation signal of the ultrasonic probe will be continuously emitted; in the pulse output mode, the excitation signal of the ultrasonic probe will be emitted in a pulsed manner with a set frequency duty cycle; the user will choose the treatment method according to the diagnosis results. Since the ultrasonic treatment head is composed of multiple array elements / channels, phase resonance focusing can be achieved. Therefore, during the treatment process, the phase resonance technology is used to adjust the energy and effect of the ultrasonic stimulation, and by controlling the signal emission of different channels and array elements, the focal position of the ultrasonic stimulation is adjusted to achieve better treatment effects.

[0096] The collecting of a large amount of real-time data of the 3D printed helmet system after wearing, modeling and analyzing the error, and further adjusting the focus position by ultrasonic phase resonance technology further include the following contents:

[0097] First, a large amount of real-time data of the 3D printed helmet system after wearing is collected, and then an artificial intelligence model is established to analyze the error of the 3D printed helmet system. After obtaining the error results, the ultrasound phase resonance technology is used to further adjust the focal position that meets the treatment requirements according to the user's diagnosis and treatment results.

[0098] Assuming that the system is mature and has obtained a large amount of diagnosis and treatment data, an artificial intelligence model is constructed based on this database to analyze the errors of the 3D printed helmet system. Assuming that most of the error analysis results are that the position of the ultrasound stimulation probe is not accurate enough for the diseased area of ​​the brain, and a rational treatment effect cannot be achieved. In addition, the helmet has been manufactured and the ultrasound stimulation probe position cannot be moved physically. In order to correct the error, it is necessary to combine the helmet positioning target positioning technology and the multi-channel ultrasound phase resonance focus fine-tuning technology to improve the accuracy of the positioning system, and then use the ultrasound phase resonance technology to further adjust the focus position that meets the treatment plan.

[0099] After the error adjustment is completed, the treatment plan is saved through the human-computer interaction panel, and the treatment plan can be adjusted as needed later to further include the following contents:

[0100] Assume that after the helmet customization is completed, the user begins to learn the system's operating procedures and treatment plan customization, such as Figure 3 As shown, through the UI of the serial port screen, users can customize, set and save treatment plans through prescriptions, and there is no need to repeat the parameter settings when performing the same type of treatment again; when selecting a plan, Plan 1 is displayed at the beginning, and there is a new function below Plan 1 to add a new plan; each plan can be edited and used, and when editing, it jumps to the mode selection page. After selecting continuous or pulse mode, it jumps to the parameter setting page; the parameter setting page can be used to set parameters such as frequency, modulation frequency, modulation duty cycle, duration, single modulation cycle time, single modulation cycle effective time, voltage, etc.

[0101] The working implementation of the human-computer interaction page is based on the combination of the upper computer and the lower computer. The working principle is that the lower computer software uses the serial port screen to provide the human-computer interaction interface, and confirms the received frame and sends the data through the communication protocol; each frame of data consists of a packet header, a packet body, and a packet tail; the packet header is fixed to 0xEE, the packet tail is fixed to 0xFF, and the function of the packet is determined by the packet body; the packet sent by the upper computer to the lower computer is a system parameter packet and a stop instruction packet; the upper computer sets the working parameters of the lower computer through the system parameter packet, and enables the lower computer to start ultrasonic treatment, and notifies the lower computer to stop ultrasonic treatment through the stop instruction packet. After the lower computer receives the data packet from the upper computer, it should return an ACK packet to indicate that the data has been received;

[0102] After clicking on the plan, the home page shows the currently selected treatment plan. When you click on output, there will be a confirmation box prompting you whether to confirm the ultrasound output. In addition, when you click on output, if there is a problem with the device and it cannot output, the device will be reminded that there is an error.

[0103] Based on the above technical solutions, the working steps of the multi-channel phase resonance transcranial ultrasound control system based on 3D printing are summarized here:

[0104] Step 1: After modeling the CT, MRI and other imaging scan data, obtain data such as the target area location information.

[0105] Step 2: After the data is processed by the upper positioning algorithm, a customized helmet design is obtained;

[0106] Step 3: The factory completes the manufacturing of customized helmets;

[0107] Step 4: Set the chassis treatment parameter information and customize the treatment plan;

[0108] Step 5: Put on the helmet for the patient and fix the ultrasound treatment head;

[0109] Step 6: Based on the data given by the artificial intelligence model, adjust the focal position in phase resonance and start treatment;

[0110] Step 7: Stop treatment and remove the helmet;

[0111] The system workflow diagram is as follows: Figure 4 shown.

[0112] It will be apparent to those skilled in the art that the invention is not limited to the details of the exemplary embodiments described above and that the invention can be implemented in other specific forms without departing from the spirit or essential features of the invention. Therefore, the embodiments should be considered exemplary and non-limiting in all respects, and the scope of the invention is defined by the appended claims rather than the foregoing description, and it is intended that all variations falling within the meaning and range of equivalent elements of the claims be included in the invention. Any reference numeral in a claim should not be considered as limiting the claim to which it relates.

Claims

1. A multi-channel phase resonance transcranial ultrasound control system based on 3D printing, characterized by: It includes a three-dimensional modeling and brain area calibration module, an ultrasonic stimulation probe calculation and design module, an ultrasonic stimulation probe module, an error modeling and adjustment module and a human-computer interaction module; the three-dimensional modeling and brain area calibration module is used to read image data, build a three-dimensional model, and perform brain area calibration; the ultrasonic stimulation probe calculation and design module is used to calculate the spatial position and angle corresponding to the ultrasonic stimulation probe, and design a personalized 3D printed helmet, and then adjust the distance between the probe and the skull surface; the ultrasonic stimulation probe module is used to use phase resonance technology to adjust the energy and effect of ultrasonic stimulation, and at the same time adjust the focal position of ultrasonic stimulation; the error modeling and adjustment module is used to collect a large amount of real-time data after the 3D printed helmet system is worn, model and analyze the errors, and further adjust the focal position through ultrasonic phase resonance technology; the human-computer interaction module is used to formulate and save treatment plans, and update the plans through an operation panel.

2. The multi-channel phase resonance transcranial ultrasound control system based on 3D printing according to claim 1, characterized in that: The three-dimensional modeling and brain area calibration module further includes an image data reading unit, a three-dimensional modeling unit and a brain area calibration unit; the image data reading unit is used to read the user's diagnostic scanning image data; the three-dimensional modeling unit is used to process the acquired head image data to construct a three-dimensional model of the user's head; the brain area calibration unit is used to calibrate the brain area that needs ultrasonic stimulation according to a given medical plan.

3. The multi-channel phase resonance transcranial ultrasound control system based on 3D printing according to claim 1, characterized in that: The ultrasound stimulation probe calculation and design module further includes an inversion calculation unit, a helmet design unit and a probe adjustment unit; the inversion calculation unit is used to calculate the spatial position and angle corresponding to the ultrasound stimulation probe according to the calibrated brain area position using inversion technology; The helmet design unit is used to design a personalized 3D printed helmet according to the calculated spatial coordinates and angles of the ultrasonic stimulation probe; the helmet comprises a chassis part, a probe part, a fixture part, a host computer software part and a slave computer software part, and the chassis part has a touch screen, a PCBA, a switching power supply, a power supply interface, a switch, and an indicator light; The touch screen contains the lower computer software, which is used to display and set relevant treatment parameters; PCBA is used to control the entire system and drive the probe; the switching power supply converts the external AC220V into DC power, which is used for the total power input of PCBA. The power supply interface serves as the AC220V input interface of the system to introduce the external power supply into the system. The switch is used to control the input of the total power supply of the system, and the indicator light is used to indicate the operating status of the system; The fixing device part fixes the ultrasonic treatment probe through the helmet body and other mechanical parts, and the head, whose inner wall matches and fits with the surface of the patient's head; a treatment head embedding structure is provided at several predetermined positions of the helmet body, and several treatment heads are detachably fixed and embedded on the helmet body. The fixing device is a 3D printed head cover, which automatically calculates the position of the ultrasonic probe according to the pre-set brain area; The upper computer software is used for preoperative positioning. The diagnostic scan data uploaded by the user is processed by inversion calculation to obtain the location of the treatment head embedding structure. The function of the lower computer is to drive the ultrasonic probe, set the ultrasonic power, and provide two ultrasonic output modes: continuous and pulsed. In the continuous output mode, the excitation signal of the ultrasonic probe will be continuously sent out. In the pulse output mode, the excitation signal of the ultrasonic probe will be sent out in pulses with a set frequency duty cycle. The ultrasonic power is mainly achieved by adjusting the voltage duty cycle of the excitation pulse. The excitation required by the ultrasonic probe is mainly provided by the half-bridge driver chip. Since the chip is equivalent to an H-bridge, the waveform required to drive this chip is provided by the complementary output function of the STM32 advanced timer with dead zone control. The control of the ultrasonic mode is achieved through the brake input function of the above function. Each advanced timer of the STM32 has a brake input channel corresponding to different pins. When the pin input is valid, the PWM output of the timer will stop. Therefore, the pulse output mode of the ultrasonic probe can be realized by connecting the PWM output of another timer to the brake input pin of the advanced timer. The duty cycle of the ultrasonic probe output can be controlled by changing the PWM duty cycle. When the duty cycle is 100%, the output mode is continuous output. The probe adjustment unit is responsible for enabling the device for fixing the ultrasonic stimulation probe to adjust the distance between the probe and the skull surface.

4. The multi-channel phase resonance transcranial ultrasound control system based on 3D printing according to claim 1, characterized in that: The ultrasound stimulation probe module further includes a multi-channel multi-element probe working unit and a focal position adjustment unit; the multi-channel multi-element probe working unit is used to adjust the energy and effect of ultrasound stimulation through phase resonance technology, and set the initial position of the ultrasound stimulation focus by controlling the signal transmission of different channels and array elements; the focal position adjustment unit adjusts the focal position of ultrasound stimulation according to treatment needs and brain area position.

5. The multi-channel phase resonance transcranial ultrasound control system based on 3D printing according to claim 1, characterized in that: The error modeling and adjustment module further includes a data acquisition unit, an artificial intelligence modeling unit and an error correction unit; the data acquisition unit is used to collect a large amount of real-time data of the 3D printed helmet system after being worn; the artificial intelligence modeling unit is used to use the collected data to establish an artificial intelligence model to analyze the errors of the 3D printed helmet system; the error correction unit is used to further adjust the focus position through ultrasonic phase resonance technology after obtaining accurate error information.

6. The multi-channel phase resonance transcranial ultrasound control system based on 3D printing according to claim 1, characterized in that: The human-computer interaction module further includes a plan formulation unit and an ultrasound output unit; The program formulation unit is used to customize, set and save treatment plans through the UI of the serial port screen. Users do not need to set parameters again when performing the same type of treatment again. When selecting a plan, plan 1 is displayed at the beginning, and there is a new function under plan 1 to add a new plan. Each plan can be edited and used. When editing, it jumps to the mode selection page. After selecting continuous or pulse mode, it jumps to the parameter setting page. The parameter setting page can be used to set frequency, modulation frequency, modulation duty cycle, duration, single modulation cycle time, single modulation cycle effective time, and voltage parameters. The ultrasound output unit is used to display the currently selected treatment plan on the home page after the plan is clicked for use. When clicking on output, there is a confirmation box prompting whether to confirm the ultrasound output. In addition, when clicking on output, if there is a problem with the device and it cannot output, the device will be reminded that an error has occurred.

7. A multi-channel phase resonance transcranial ultrasound control method based on 3D printing, characterized in that: The method steps include the following: S1. Read the user's diagnostic imaging data, build a three-dimensional model, and calibrate the brain area to be treated; S2. Calculate the spatial position and angle of the ultrasound stimulation probe according to the calibrated brain area position, design a personalized 3D printed helmet, and then adjust the distance between the probe and the skull surface; S3. After the helmet is manufactured, phase resonance technology is used to adjust the energy and effect of ultrasound stimulation according to the diagnosis and treatment results of the user, and the focal position of ultrasound stimulation is adjusted at the same time; S4. After the treatment, a large amount of real-time data of the 3D printed helmet system is collected, the error is modeled and analyzed, and the focus position is further adjusted through ultrasonic phase resonance technology; S5. After the error adjustment is completed, the treatment plan is saved through the human-computer interaction panel, and the treatment plan can be adjusted as needed later.

8. The multi-channel phase resonance transcranial ultrasound control method based on 3D printing according to claim 7, characterized in that: The reading of the user's diagnostic imaging data, construction of a three-dimensional model, and calibration of the brain region to be treated further include the following contents: first, reading the user's diagnostic scanning imaging data, then processing the acquired head imaging data, and constructing a three-dimensional model of the user's head; and finally, calibrating the brain region to be treated with ultrasound according to the given medical plan.

9. The multi-channel phase resonance transcranial ultrasound control method based on 3D printing according to claim 7, characterized in that: The method further includes the following steps: calculating the spatial position and angle of the ultrasound stimulation probe according to the calibrated brain region position, designing a personalized 3D printed helmet, and then adjusting the distance between the probe and the skull surface: First, the inversion technology is used to calculate the spatial position and angle of the ultrasound stimulation probe according to the calibrated brain area position; then, a personalized 3D printed helmet is designed based on the calculated spatial coordinates and angle of the ultrasound stimulation probe; the helmet consists of a chassis part, a probe part, a fixture part, a host computer software part and a slave computer software part. The chassis part has a touch screen, PCBA, a switching power supply, a power supply interface, a switch, and an indicator light; The touch screen contains the lower computer software, which is used to display and set relevant treatment parameters; PCBA is used to control the entire system and drive the probe; the switching power supply converts the external AC220V into DC power, which is used for the total power input of PCBA. The power supply interface serves as the AC220V input interface of the system to introduce the external power supply into the system. The switch is used to control the input of the total power supply of the system, and the indicator light is used to indicate the operating status of the system; The fixing device part fixes the ultrasonic treatment probe through the helmet body and other mechanical parts, and the head, whose inner wall matches and fits with the surface of the patient's head; a treatment head embedding structure is provided at several predetermined positions of the helmet body, and several treatment heads are detachably fixed and embedded on the helmet body. The fixing device is a 3D printed head cover, which automatically calculates the position of the ultrasonic probe according to the pre-set brain area; The upper computer software is used for preoperative positioning. The diagnostic scan data uploaded by the user is processed by inversion calculation to obtain the location of the treatment head embedding structure. The function of the lower computer is to drive the ultrasonic probe, set the ultrasonic power, and provide two ultrasonic output modes: continuous and pulsed. In the continuous output mode, the excitation signal of the ultrasonic probe will be continuously sent out. In the pulse output mode, the excitation signal of the ultrasonic probe will be sent out in pulses with a set frequency duty cycle. The ultrasonic power is mainly achieved by adjusting the voltage duty cycle of the excitation pulse. The excitation required by the ultrasonic probe is mainly provided by the half-bridge driver chip. Since the chip is equivalent to an H-bridge, the waveform required to drive this chip is provided by the complementary output function of the STM32 advanced timer with dead zone control. The control of the ultrasonic mode is achieved through the brake input function of the above function. Each advanced timer of the STM32 has a brake input channel corresponding to different pins. When the pin input is valid, the PWM output of the timer will stop. Therefore, the pulse output mode of the ultrasonic probe can be realized by connecting the PWM output of another timer to the brake input pin of the advanced timer. The duty cycle of the ultrasonic probe output can be controlled by changing the PWM duty cycle. When the duty cycle is 100%, the output mode is continuous output. Finally, the device for fixing the ultrasound stimulation probe is used to adjust the distance between the probe and the skull surface according to the helmet design results and the user's diagnosis and treatment plan; After the helmet is manufactured, the phase resonance technology is used to adjust the energy and effect of the ultrasound stimulation according to the diagnosis and treatment results of the user, and the focal position of the ultrasound stimulation is further adjusted, including the following: First, the energy and effect of ultrasound stimulation are adjusted through phase resonance technology, and the initial position of the ultrasound stimulation focus is set by controlling the signal transmission of different channels and array elements; then, the focal position of ultrasound stimulation is adjusted according to treatment needs and brain area location.

10. The multi-channel phase resonance transcranial ultrasound control method based on 3D printing according to claim 7, characterized in that: The collecting of a large amount of real-time data of the 3D printed helmet system after wearing, modeling and analyzing the error, and further adjusting the focus position by ultrasonic phase resonance technology further include the following contents: First, a large amount of real-time data of the 3D printed helmet system after wearing is collected, and then an artificial intelligence model is established to analyze the error of the 3D printed helmet system. After obtaining the error results, the ultrasound phase resonance technology is used to further adjust the focal position that meets the treatment requirements according to the user's diagnosis and treatment results. After the error adjustment is completed, the treatment plan is saved through the human-computer interaction panel, and the treatment plan can be adjusted as needed later to further include the following contents: After the helmet is customized, the user can customize, set and save the treatment plan through the UI of the serial port screen through the prescription, and there is no need to repeat the parameter setting when the same type of treatment is carried out again; when selecting the plan, Plan 1 is displayed at the beginning, and there is a new function under Plan 1 to add a new plan; each plan can be edited and used, and the page for mode selection is jumped to when editing. After selecting continuous or pulse mode, it jumps to the parameter setting page; the parameter setting page can be used to set frequency, modulation frequency, modulation duty cycle, duration, single modulation cycle time, single modulation cycle effective time, and voltage parameters; After clicking on the plan, the home page shows the currently selected treatment plan. When you click on output, there will be a confirmation box prompting you whether to confirm the ultrasound output. In addition, when you click on output, if there is a problem with the device and it cannot output, the device will be reminded that there is an error.

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