Comprehensive separation and purification platform and its control system

Abstract

The present invention discloses a comprehensive separation and purification platform and its control system, which relates to the technical field of drug separation and purification, and includes a separation tower, a filtering mechanism, a fixed column, a lifting component, a detection component and a control module, wherein the interior of the separation tower is hollow, the filtering mechanism is arranged in the inner cavity of the separation tower, the input port of the filtering mechanism is connected to a feed pipe, and the output port of the filtering mechanism is provided with a feed pipe, the fixed column is connected to the inner wall of the separation tower, a cavity is formed inside the fixed column, the lifting component is arranged in the cavity of the fixed column, the lifting part of the lifting component is provided with an adsorption unit, the side wall of the fixed column is connected with a waste liquid pipe and a connecting pipe, the output port of the fixed column is provided with a filtering pipe, the detection component is arranged in the inner cavity of the separation tower, the detection component is connected to the filtering pipe, and the filtering pipe is also connected to the output pipe. The present application has the effect of improving the separation effect of the target substance.

Description

Technical Field

[0001] The present application relates to the technical field of drug separation and purification, and in particular to a comprehensive separation and purification platform and a control system thereof. Background Art

[0002] Separation and purification is a technology used to obtain target components from a mixture. In the fields of scientific research, industrial production, and pharmaceutical manufacturing, it is often necessary to separate the target substance from a complex mixture in order to achieve the purpose of analysis, preparation, or application.

[0003] At present, separation and purification usually adopts centrifugal technology, which uses centrifugal force to make substances produce sedimentation speed differences in a rotating field to achieve separation. However, when drugs are separated using centrifugal technology, they are easily affected by many factors, including centrifuge speed, centrifuge tube selection size, operational errors, etc. Among them, too low centrifuge speed may lead to incomplete separation, while too high speed may cause sample breakage or loss. At the same time, the centrifuge speed will also be affected by failure or wear of the centrifuge's motor, bearings, etc., which can easily lead to poor separation effect. Therefore, the present application provides a new technical solution. Summary of the invention

[0004] In order to improve the separation and purification effect of the target substance, the present application provides a comprehensive separation and purification platform and its control system.

[0005] The present application provides a comprehensive separation and purification platform and its control system, which adopts the following technical solutions:

[0006] A comprehensive separation and purification platform, characterized in that it comprises a separation tower, a filtering mechanism, a fixed column, a lifting assembly, a detection element and a control module, wherein the interior of the separation tower is hollow, the filtering mechanism is arranged at the upper part of the inner cavity of the separation tower, the input port of the filtering mechanism is connected to the feed pipe of the separation tower, and the output port of the filtering mechanism is provided with a feed pipe, the fixed column is fixedly connected to the inner wall of the separation tower, and the fixed column is located below the filtering mechanism, a cavity is formed inside the fixed column and a through opening is arranged at the upper part of the cavity, the lifting assembly is arranged in the cavity of the fixed column, and the lifting part of the lifting assembly fits the through opening on the cavity of the fixed column, The lifting part of the lifting assembly is provided with an adsorption unit for adsorbing the target substance and a liquid level sensor for detecting the liquid level of the raw material medicine. The side wall of the fixed column is connected with a waste liquid pipe extending out of the separation tower and a connecting pipe, and the connecting pipe is located below the waste liquid pipe. The output port of the fixed column is provided with a filter pipe connected to its cavity. The detection member is arranged in the inner cavity of the separation tower and is located below the fixed column. The sampling end of the detection member is connected to one end of the filter pipe extending out of the fixed column and is used to detect the separation results of the target substance. The filter pipe is also connected to the output pipe of the separation tower. The control module is electrically connected to the detection member, the lifting assembly and the liquid level sensor.

[0007] Wherein, the control module is configured as follows:

[0008] If a separation demand signal of the API liquid is received, the lifting component is controlled to reset to a preset initial position;

[0009] After the preset T1 time, the lifting component is controlled to descend to the preset API waste liquid discharge position;

[0010] If the detection value fed back by the liquid level sensor meets the preset liquid level value, the lifting component is controlled to descend to the preset target material discharge position.

[0011] Optionally, the lifting assembly includes a hydraulic cylinder and a lifting platform, a groove is provided at the bottom of the cavity of the fixed column, the cylinder body of the hydraulic cylinder is arranged in the groove, and the telescopic rod of the hydraulic cylinder is extended vertically upward, the lifting platform is fixedly connected to the end of the telescopic rod of the hydraulic cylinder, the adsorption unit is arranged on the upper surface of the lifting platform, and a limiting groove is provided on the upper surface of the lifting platform, the liquid level sensor is arranged in the limiting groove, and the detection end of the liquid level sensor is extended vertically upward and extends out of the limiting groove.

[0012] Optionally, a filter screen is fixedly connected to the inner wall of the filter pipe, a fixed phase is provided on the upper surface of the filter screen, a three-way reversing valve is provided at the bottom of the separation tower, and the three-way reversing valve is located below the detection component, the input port of the three-way reversing valve is connected to the lower end of the filter pipe and is used to receive liquid flowing out of the filter pipe, the output port of the three-way reversing valve is provided with a first valve, a second valve and a third valve, the first valve is connected to a waste liquid pipe 2, the other end of the waste liquid pipe 2 extends out of the separation tower, a circulation component is provided outside the separation tower, the input port of the circulation component is connected to the second valve, the output port of the circulation component is connected to the separation tower and the output port is located above the fixed column, the third valve is connected to the output pipeline of the separation tower, the filter pipe is provided with an electromagnetic valve 1, and the electromagnetic valve 1 is arranged between the detection component and the three-way reversing valve, and the control module is electrically connected to the electromagnetic valve 1, the three-way reversing valve and the circulation component respectively;

[0013] Wherein, the control module is configured as follows:

[0014] If the detection completion signal output by the detection component is received, the electromagnetic valve is controlled to act;

[0015] If the detection value fed back by the detection component does not meet the preset target substance separation requirements, the second valve is controlled to open and the circulation component is activated;

[0016] If the detection value fed back by the detection component meets the preset target substance separation requirements, the third valve is controlled to open;

[0017] After the preset T2 duration, the first valve is controlled to open.

[0018] Optionally, the circulation component includes a circulation tank and a reflux pipe arranged on the outside of the separation tower, the interior of the circulation tank is hollow and is connected to a circulation pump, the input port of the circulation tank is connected to the second valve through a pipe, one end of the reflux pipe is connected to the output end of the circulation tank, and the other end of the reflux pipe extends toward the upper part of the fixed column and is connected to the inner cavity of the separation tower, and the connection point is located above the fixed column.

[0019] Optionally, the filtering mechanism includes a filtering assembly and a filter tank, the filter tank is vertically arranged in the inner cavity of the separation tower, the interior of the filter tank is hollow and a through opening is arranged on the upper surface of the filter tank, a protective cover is arranged at the through opening of the filter tank, the feed pipe of the separation tower is passed through the protective cover and extends into the inner cavity of the filter tank, the feed pipe is arranged at the bottom of the filter tank, the upper end of the feed pipe is connected with the inner cavity of the filter tank, and the filtering assembly is arranged in the inner cavity of the filter tank.

[0020] Optionally, the filter assembly includes a fixed block and a filter membrane, the fixed block is fixedly connected to the inner wall of the filter tank, the fixed block is vertically penetrated with a plurality of filter holes, the upper surface of the fixed block is protruding in an arc shape, and the filter membrane is arranged on the upper surface of the fixed block.

[0021] Optionally, a liquid storage tank and a suction pump are fixedly connected to the inner wall of the separation tower, a drainage tube is provided on the side wall of the filter tank, one end of the drainage tube is connected to the inner cavity of the filter tank and the connection point is located at the lowest point of the arc-shaped protrusion of the fixed block, the other end of the drainage tube is connected to the input port of the liquid storage tank, the output port of the liquid storage tank is connected to the suction pump through a pipeline, the pipeline of the suction pump is fixedly penetrated through the protective cover, the separation tower is provided with a waste liquid pipe three, and the waste liquid pipe three is located below the drainage pipe, one end of the waste liquid pipe three is connected to the lower end of the drainage pipe, and the other end of the waste liquid pipe three extends out of the separation tower, a ranging sensor is fixedly connected to the lower surface of the protective cover, the drainage pipe is provided with an electromagnetic valve two at the connection between the drainage pipe and the filter tank, the waste liquid pipe three is provided with an electromagnetic valve three at the connection between the drainage pipe and the drainage pipe, and the control module is electrically connected to the electromagnetic valve two, the electromagnetic valve three, the suction pump and the ranging sensor respectively;

[0022] Wherein, the control module is configured as follows:

[0023] If the detection value fed back by the distance measuring sensor meets the preset one-time filtering completion condition within the preset T3 time, the electromagnetic valve 2 is controlled to open;

[0024] If the detection value fed back by the distance measuring sensor meets the preset secondary filtering condition, the second electromagnetic valve is controlled to be closed and the suction pump is turned on;

[0025] If the detection value fed back by the distance measuring sensor meets the preset waste liquid discharge condition, the electric measuring valve 2 and the electromagnetic valve 3 are controlled to open.

[0026] Optionally, a refrigeration unit for reducing the temperature of the inner cavity of the separation tower is fixedly connected to the upper surface of the separation tower.

[0027] A comprehensive separation and purification platform control system, characterized in that it includes a memory and a processor, wherein the memory stores a computer program that can be loaded by the processor and execute the comprehensive separation and purification platform as described in any one of claims 1-8.

[0028] In summary, the present application includes the following beneficial technical effects: the present application filters the API liquid by setting up a filtering mechanism, and transports the filtered API liquid to the upper part of the fixed column, and after adsorption and separation by the adsorption unit, transports it to the detection element to detect the separation effect of the target substance and outputs it from the output pipeline, thereby improving the separation and purification effect of the target substance. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 It is a schematic diagram of the overall structure of an embodiment of the present application;

[0030] Figure 2 is a partial cross-sectional view of a separation tower according to an embodiment of the present application;

[0031] Figure 3 is a cross-sectional view of a filter tank and a fixing column according to an embodiment of the present application;

[0032] Figure 4 It is a structural schematic diagram of the three-way reversing valve of an embodiment of the present application.

[0033] Explanation of reference numerals: 1. separation tower; 11. feed pipe; 12. discharge pipe; 13. output pipe; 14. waste liquid pipe 2; 15. refrigeration unit; 2. filter mechanism; 21. filter assembly; 211. fixed block; 212. filter membrane; 22. filter tank; 221. protective cover; 222. drainage pipe; 223. waste liquid pipe 3; 224. distance sensor; 225. electromagnetic valve 2; 226. electromagnetic valve 3; 3. fixed column ; 31. Waste liquid pipe 1; 32. Connecting pipe; 33. Filter pipe; 34. Groove; 35. Filter; 36. Solenoid valve 1; 4. Lifting assembly; 41. Liquid level sensor; 42. Hydraulic cylinder; 43. Lifting platform; 431. Limiting groove; 5. Detection part; 6. Control module; 7. Three-way reversing valve; 71. First valve; 72. Second valve; 73. Third valve; 8. Circulation part; 81. Circulation tank; 82. Reflux pipe. DETAILED DESCRIPTION

[0034] The following is combined with Figure 1-4This application is described in further detail.

[0035] The embodiments of the present application disclose a comprehensive separation and purification platform.

[0036] Reference Figure 1 and Figure 2 The comprehensive separation and purification platform includes a separation tower 1, a filtering mechanism 2, a fixed column 3, a lifting component 4, a detection component 5 and a control module 6.

[0037] Among them, the control module 6 is a PLC control cabinet, the interior of the separation tower 1 is hollow, the upper surface of the separation tower 1 is provided with an opening and a detachable end cap is provided at the opening. The filter mechanism 2 is arranged at the upper part of the inner cavity of the separation tower 1, the input port of the filter mechanism 2 is connected to the feed pipe 11 of the separation tower 1, the feed pipe 11 is used to transport the raw material liquid, the fixed column 3 is arranged in the inner cavity of the separation tower 1, and the fixed column 3 is located below the filter mechanism 2, a cavity is formed inside the fixed column 3, and an opening is provided at the upper part of the cavity, the output port of the filter mechanism 2 is connected to the feed pipe 12, and the other end of the feed pipe 12 is extended toward the fixed column 3, and is used to transport the raw material liquid obtained after the filter mechanism 2 preliminarily filters the impurities to the fixed column 3.

[0038] The fixed column 3 is fixedly connected to the inner wall of the separation tower 1 by bolts, and the lifting component 4 is arranged in the cavity of the fixed column 3. The lifting part of the lifting component 4 is provided with an adsorption unit for adsorbing the target substance from the raw material liquid. The adsorption unit in this embodiment can be activated carbon that utilizes the physical properties of the target substance for adsorption, so that the target substance in the raw material liquid is adsorbed and separated by the adsorption unit of the lifting part of the lifting component 4. The lifting part of the lifting component 4 fits into the opening above the cavity of the fixed column 3, and when the equipment is in the adsorption process, the lifting part is located at the opening of the fixed column 3.

[0039] A liquid level sensor 41 is also provided on the lifting part of the lifting assembly 4. The liquid level sensor 41 is used to detect whether the bulk drug waste liquid reaches the predicted liquid level detection value. The liquid level sensor 41 in this embodiment can be a float type liquid level sensor.

[0040] Reference Figure 3 A waste liquid pipe 31 and a connecting pipe 32 are fixedly connected to the side wall of the fixed column 3, wherein the connecting pipe 32 is located below the waste liquid pipe 31, and both the waste liquid pipe 31 and the connecting pipe 32 are connected to the cavity of the fixed column 3, and the connection point between the waste liquid pipe 31 and the cavity of the fixed column 3 is located at the opening of the fixed column 3.

[0041] Reference Figure 2The inner wall of the separation tower 1 is fixedly connected with a fixing plate by bolts, and the fixing plate is located below the fixing column 3. The detection component 5 is fixedly arranged on the upper surface of the fixing plate. The detection component 5 can be a mass spectrometer that identifies quantitative compounds by measuring the mass-to-charge ratio of sample molecules. The output port of the fixed column 3 is provided with a filtering pipe 33 connected to its cavity. The sampling end of the detection component 5 is connected to one end of the filtering pipe 33 extending out of the fixed column 3. The separation results of the target substance are detected by the detection component 5. The filtering pipe 33 is also connected to the output pipe 13 of the separation tower 1, and is used to output the raw material liquid from the separation tower 1.

[0042] The detection member 5, the lifting assembly 4 and the liquid level sensor 41 are electrically connected to the control module 6 respectively, and the control module 6 is configured as follows:

[0043] 1) If a separation demand signal of the API liquid is received, the lifting component 4 is controlled to be reset to a preset initial position;

[0044] It can be understood that the separation demand signal of the API liquid can be that before the API liquid needs to be input into the feed pipe 11 of the separation tower 1, the staff presses the reset button of the lifting component 4 prefabricated on the control cabinet; the preset initial position of the lifting component 4 refers to the position when the upper surface of the lifting part of the lifting component 4 is flush with the upper surface of the fixed column 3.

[0045] 2) After the preset T1 time, the lifting component 4 is controlled to descend to the preset position for discharging the bulk drug waste liquid.

[0046] It can be understood that the preset T1 duration is set according to the time required for the adsorption unit to adsorb the target substance, and the preset API waste liquid discharge position refers to the position where the lifting part of the lifting component 4 is located at the pipe mouth of the waste liquid pipe 31.

[0047] 3) If the detection value fed back by the liquid level sensor 41 meets the preset liquid level value, the lifting assembly 4 is controlled to descend to the preset target material discharge position.

[0048] It can be understood that the target material discharge position refers to the position where the upper surface of the lifting component 4 is located below the connecting pipe 32.

[0049] Through the above arrangement, when the raw material drug liquid flows into the separation tower 1 through the feed pipe 11, the raw material drug liquid flows through the filtering mechanism 2 and then flows into the top of the fixed column 3 from the feed pipe 12. After the target substance is adsorbed and separated by the adsorption unit on the lifting part of the lifting component 4, the lifting part descends to the raw material drug waste liquid filtration position, and after the raw material drug waste liquid is output from the separation tower 1 through the waste liquid pipe 31, the lifting part descends to the target substance separation position, and the mobile phase is input through the connecting pipe 33 (the mobile phase is a substance that carries the target substance to move. Different mobile phases can be selected according to different target substances. The mobile phase in this embodiment can be acetonitrile-water solution), driving the target substance on the adsorption unit to flow to the detection element 5 through the filtering pipe 33 for detection, and then flows out through the output pipe 13 of the separation tower 1.

[0050] Reference Figure 3 The lifting assembly 4 includes a hydraulic cylinder 42 and a lifting platform 43. A groove 34 is provided at the bottom of the cavity of the fixed column 3. At least the upper opening of the groove 34 is adapted to the lifting platform 43. The cylinder body of the hydraulic cylinder 42 is fixed in the groove 34, and the telescopic rod of the hydraulic cylinder 42 is vertically extended upward. The lifting platform 43 is fixedly connected to the end of the telescopic rod of the hydraulic cylinder 42, and the adsorption unit is arranged on the upper surface of the lifting platform 43.

[0051] When the telescopic rod of the hydraulic cylinder 42 is reset, the upper surface of the lifting platform 43 is flush with the upper surface of the fixed column 3, and the side wall of the lifting platform 43 is in contact with the inner edge of the opening at the top of the fixed column 3. The adsorption unit adsorbs the target substance from the raw material liquid. Then, when the lifting assembly 4 descends to the target substance discharging position, the lifting platform 43 is hidden in the groove 34.

[0052] In order to prevent the telescopic rod of the hydraulic cylinder 42 from contaminating the liquid, a telescopic bellows is provided on the cylinder body of the hydraulic cylinder 42 and the telescopic rod. One end of the bellows is fixedly connected to the end of the telescopic rod, and the other end of the bellows is fixedly connected to the cylinder body of the hydraulic cylinder 42, so that when the telescopic rod is extended or retracted, the liquid is prevented from being contaminated by the contact between the raw material liquid and the side wall of the telescopic rod.

[0053] A limit groove 431 is provided on the upper surface of the lifting platform 43, and the liquid level sensor 41 is fixed in the limit groove 431, and the detection end of the liquid level sensor 41 vertically extends upward from the limit groove 431, and the adsorption unit and the liquid level sensor 41 are staggered to prevent the adsorption unit from blocking the detection end of the liquid level sensor 41 and affecting the detection of the liquid level sensor 41.

[0054] A sealing sheet is provided at the opening of the limiting groove 431 to prevent the API liquid from flowing into the limiting groove 431 , thereby preventing other API liquids remaining in the limiting groove 431 from causing contamination when the separation tower 1 is in use, thereby preventing cross contamination of the API liquids.

[0055] Reference Figure 3 In another embodiment of the present application, considering that the adsorption unit may adsorb other raw material drug components from the raw material drug liquid, a filter screen 35 is fixedly connected to the inner wall of the filter pipe 33, and a stationary phase is arranged on the filter screen 35. The stationary phase provides a chemical environment different from the mobile phase for the sample molecules. Due to the different retention capacities of different sample molecules on the stationary phase, the speeds of each component passing through the stationary phase under the promotion of the mobile phase are different, thereby achieving separation of each component on the stationary phase. Therefore, under the action of the stationary phase and the mobile phase, the target substance can flow through the filter screen 35 first, and after a certain period of time, the waste liquid (liquid that does not contain the target substance) flows down through the filter screen 35.

[0056] A three-way reversing valve 7 is provided at the bottom of the separation tower 1, and a support frame is fixedly installed at the bottom of the separation tower 1 by bolts. The three-way reversing valve 7 is mounted on the support frame, and the three-way reversing valve 7 is located below the detection component 5. The input port of the three-way reversing valve 7 is connected to the lower end of the filtering pipe 33, and the output port of the three-way reversing valve 7 is provided with a first valve 71, a second valve 72, and a third valve 73. The first valve 71 is connected to the waste liquid pipe 14, and the other end of the waste liquid pipe 14 extends out of the separation tower 1. A circulation component 8 is provided outside the separation tower 1, and the input port of the circulation component 8 is connected to the second valve 72. The output port of the circulation component 8 is connected to the separation tower 1 and the output port is located above the fixed column 3. The liquid flowing through the filtering pipe 33 is drained into the cavity of the fixed column 3 again through the circulation component 8, and the liquid is separated again to improve the separation effect. The third valve 73 is connected to the output pipe 13 of the separation tower 1, and the target substance is output from the separation tower 1 through the third valve 73.

[0057] The filter pipe 33 is provided with an electromagnetic valve 1 36, and the installation position of the electromagnetic valve 1 36 is located between the connection point between the detection element 5 and the filter pipe 33 and the connection point between the three-way reversing valve 7 and the filter pipe 33. The control module 6 is electrically connected to the electromagnetic valve 1 36, the three-way reversing valve 7 and the circulation element 8, respectively, and the control module 6 is configured as follows:

[0058] If the detection completion signal output by the detection element 5 is received, the electromagnetic valve 36 is controlled to act;

[0059] It can be understood that the detection completion signal refers to the detection value output by the detection component 5 after completing the detection of the target substance separation results, and the action of the electromagnetic valve 36 refers to the opening of the electromagnetic valve 36 (in this embodiment, the electromagnetic valve 36 is in a long-closed state).

[0060] If the detection value fed back by the detection element 5 does not meet the preset target substance separation requirements, the second valve 72 is controlled to open and the circulation element 8 is activated;

[0061] It can be understood that the target substance separation requirement refers to the content of the target substance required to be achieved after separation by the separation tower 1 .

[0062] If the detection value fed back by the detection element 5 meets the preset target substance separation requirement, the third valve 73 is controlled to open;

[0063] After the preset time T2, the first valve 71 is controlled to open.

[0064] It is understandable that since the target substance flows out of different stationary phases through different mobile phases at different speeds, the preset T2 time should be determined in combination with the selected mobile phase and stationary phase, based on the time required for the target substance to completely flow out of the stationary phase.

[0065] Through the above arrangement, the electromagnetic valve 36 is in a long-closed state, and the target substance flows out of the filter pipe 33 and flows to the detection component 5 for detection. When the detection component 5 outputs a detection signal, the electromagnetic valve 36 opens, and the target substance flows to the three-way reversing valve 7. If the detection value fed back by the detection component 5 does not meet the separation requirement of the target substance, the second valve 72 is controlled to open, and the target substance is input from the circulation component 8 into the cavity of the fixed column 3 again, and separated again until the separation effect fed back by the detection component 5 meets the separation requirement, then the third valve 73 is opened, and after the target substance is transported to the outside of the separation tower 1, the first valve 71 is opened, and the waste liquid is discharged from the separation tower 1 through the waste liquid pipe 14.

[0066] The circulation component 8 includes a circulation tank 81 and a reflux pipe 82. The interior of the circulation tank 81 is hollow, and the two ends are respectively set as an input port and an output port. The input port of the circulation tank 81 is connected to the second valve 72 through a pipeline, and the reflux pipe 82 is connected to the output port of the circulation tank 81, and the other end of the reflux pipe 82 extends into the inner cavity of the separation tower 1 and is located above the fixed column 3.

[0067] When the second valve 72 is opened, the liquid flows into the circulation tank 81 through the pipeline. A circulation pump is provided in the circulation tank 81. The liquid is pressed into the upper part of the fixed column 3 along the reflux pipeline 82 by the circulation pump. That is, the liquid flows into the cavity of the fixed column 3 again and is filtered again through the filtering pipeline 33 to realize the circulation separation of the liquid and improve the separation effect of the target substance.

[0068] Reference Figure 2 and Figure 3The filtering mechanism 2 includes a filtering assembly 21 and a filtering tank 22. A fixing frame is fixedly connected to the upper part of the inner cavity of the separation tower 1 by bolts. The filtering tank 22 is vertically mounted on the fixing frame. The interior of the filtering tank 22 is hollow and a through opening is arranged on the upper surface of the filtering tank 22. A detachable protective cover 221 is fixedly connected to the through opening of the filtering tank 22 by bolts. The feed pipe 11 of the separation tower 1 is passed through the protective cover 221 and extends into the inner cavity of the filtering tank 22. The feeding pipe 12 is fixedly connected to the bottom of the filtering tank 22, and the upper end of the feeding pipe 12 is communicated with the inner cavity of the filtering tank 22. The lower end of the feeding pipe 12 is extended toward the upper part of the fixing column 3. The filtering assembly 21 is arranged in the inner cavity of the filtering tank 22.

[0069] Reference Figure 3 The filter assembly 21 includes a fixed block 211 and a filter membrane 212. The fixed block 211 is welded to the inner wall of the filter tank 212, and the fixed block 211 is penetrated with a plurality of filter holes in the vertical direction. The filter membrane 212 is laid on the upper surface of the fixed block 211, and the edge of the filter membrane 212 is in contact with the inner wall of the filter tank 22. After the raw material drug liquid passes through the filter membrane 212, the raw material drug waste liquid is left on the upper part, and the raw material drug liquid containing the target substance flows downward. The filter membrane 212 can be a polytetrafluoroethylene filter membrane for separating acid / alkali solutions.

[0070] The API liquid flows into the filter tank 22 through the feed pipe 11, and through the filtering action of the filter assembly 21, the API waste liquid is left on the upper part. The filtered API liquid flows into the fixed column 3 through the discharge pipe 12 for separation.

[0071] In another embodiment of the present application, in order to better separate the raw material liquid, a drainage pipe 222 is provided on the side wall of the filter tank 22, one end of the drainage pipe 222 is connected to the inner cavity of the filter tank 22, and a liquid storage tank and a suction pump are fixedly connected to the inner wall of the separation tower 1, the other end of the drainage pipe 222 is connected to the input port of the liquid storage tank, and the output port of the liquid storage tank is connected to the suction pump through a pipeline, and the pipeline of the suction pump is fixedly penetrated through the protective cover 221. In order to facilitate the discharge of the raw material waste liquid from the filter tank 22, a waste liquid pipe three 223 is provided below the drainage pipe 222, one end of the waste liquid pipe three 223 is connected to the lower end of the drainage pipe 222, and the other end of the waste liquid pipe three 223 extends out of the separation tower 1.

[0072] A distance sensor 224 is fixedly connected to the lower surface of the protective cover 221, and the detection end of the distance sensor 224 extends vertically downward, and the liquid level of the raw material liquid above the filter membrane 212 is detected by the detection value fed back by the distance sensor 224. The drainage tube 222 is provided with an electromagnetic valve 225 at the connection between it and the filter tank 22, and the waste liquid pipe 3 223 is provided with an electromagnetic valve 3 226 at the connection between it and the drainage tube 222. The control module 6 is electrically connected to the electromagnetic valve 225, the electromagnetic valve 3 226, the suction pump and the distance sensor 224, and the control module 6 is configured as follows:

[0073] If the detection value fed back by the distance measuring sensor 224 meets the preset one-time filtering completion condition within the preset T3 time, the electromagnetic valve 225 is controlled to open;

[0074] It can be understood that the preset T3 duration refers to the time interval between two feedback detection values ​​of the distance sensor 224 set by the staff. In this embodiment, the T3 duration can be set to 10 minutes. The condition for the completion of one filtration refers to the fact that there is no change in the two adjacent detection values ​​output by the distance sensor 224 (in this embodiment, the electromagnetic valve 225 is in a long closed state), which means that there is liquid accumulation on the filter membrane 212 at this time, and the accumulated liquid still cannot pass through the filter membrane 212 smoothly within the set T3 duration. In this case, the electromagnetic valve 225 is opened to allow the accumulated liquid to flow into the liquid storage tank through the drainage tube 222.

[0075] If the detection value fed back by the distance measuring sensor 224 meets the preset secondary filtering condition, the electromagnetic valve 2 225 is controlled to be closed and the suction pump is turned on;

[0076] It can be understood that the preset secondary filtration condition refers to that the detection value fed back by the distance measuring sensor 224 is the distance between its detection end and the filter membrane 212, which means that the accumulated liquid above the filter membrane 212 has been discharged from the filter tank 22 through the drainage tube 222, then the electromagnetic valve 225 is closed and the suction pump is turned on to re-inject the accumulated liquid into the filter tank 22.

[0077] If the detection value fed back by the distance measuring sensor 224 meets the preset discharge condition of the bulk drug waste liquid, the electromagnetic valve 2 25 and the electromagnetic valve 3 226 are controlled to open.

[0078] It is understandable that the discharge conditions of API waste liquid refer to:

[0079] (1) Satisfy the secondary filtering conditions; (2) Pass the preset T4 duration.

[0080] After the accumulated liquid that flows into the filter tank 22 again is filtered again by the filter membrane 212, the solenoid valve 225 and the solenoid valve 3 226 are controlled to open, so that the waste liquid that cannot pass through the filter membrane 212 is discharged from the waste liquid pipe 3 223; wherein, the time T4 can be adjusted by the staff according to the actual progress of the target drug separation, or the T4 duration can be set to be less than the T3 duration (in this embodiment, the solenoid valve 3 226 is in a long closed state).

[0081] Through the above arrangement, when the liquid level of the raw material drug liquid fed back by the distance sensor 224 remains unchanged, the electromagnetic valve 225 is opened, and the raw material drug liquid flows into the liquid storage tank through the drainage tube 222. After the detection value fed back by the distance sensor 224 meets the secondary filtration condition, the electromagnetic valve 225 is reset, and the suction pump is started to send the raw material drug liquid in the liquid storage tank back into the filter tank 22 through the pipeline and filter it again. After T4 time, the electromagnetic valve 225 and the electromagnetic valve 3 226 are opened at the same time, and the raw material drug waste liquid above the filter membrane flows into the waste liquid pipe 3 223 through the drainage tube 222 and is discharged from the separation tower 1.

[0082] Reference Figure 3 In order to facilitate the raw material liquid above the filter membrane 212 to flow out from the drainage tube 222, the upper surface of the fixed block 211 is convex, and the connection between the drainage tube 222 and the inner cavity of the filter tank 22 is located at the lowest point of the arc-shaped protrusion of the fixed block 211.

[0083] Reference Figure 2 In another embodiment of the present application, in order to provide a low-temperature environment for the separation of the target substance to improve its separation effect, a refrigeration unit 15 is fixedly connected to the upper surface of the separation tower 1 by bolts. The refrigeration unit 15 can be a refrigeration compressor. The refrigeration end of the refrigeration unit 15 is arranged in the inner cavity of the separation tower 1. The refrigeration end of the refrigeration unit 15 works to reduce the temperature of the inner cavity of the separation tower 1, thereby achieving low-temperature separation of the target substance and improving the separation effect of the target substance.

[0084] The embodiment of the present application also discloses a comprehensive separation and purification platform control system.

[0085] The comprehensive separation and purification platform control system comprises a memory and a processor, wherein the memory is used to store a computer program that can be loaded by the processor and executed as any of the above-mentioned comprehensive separation and purification platforms.

[0086] The implementation principle of this embodiment is as follows: the raw material drug liquid is transported to the filter tank 22, and the raw material drug liquid passing through the filter membrane 212 flows from the feed pipe 12 into the upper part of the fixed column 3. After the adsorption unit on the upper surface of the lifting platform 43 adsorbs the target substance, the lifting component 4 descends to the preset raw material drug waste liquid discharge position, and the raw material drug waste liquid is discharged from the waste liquid pipe 31 out of the separation tower 1. The lifting component 4 descends to the target substance separation position, and the mobile phase is input from the connecting pipe 32 into the cavity of the fixed column 3 and drives the target substance to pass through the stationary phase in the filter pipe 33. The liquid containing the target substance flowing out of the filter pipe 33 flows into the detection component 5 to detect the separation result of the target substance, and the electromagnetic valve 36 is opened. If the separation requirement is not met, the second valve 72 of the three-way reversing valve 7 connected to the lower end of the filter pipe 33 is opened, and the liquid is input into the cavity of the fixed column 3 again through the circulation component 8 for filtration to improve the separation effect of the target substance, until the separation result meets the separation requirement, the third valve 73 is opened to output the target substance from the separation tower 1.

[0087] The above are all preferred embodiments of the present application, and the protection scope of the present application is not limited thereto. Therefore, any equivalent changes made according to the structure, shape, and principle of the present application should be included in the protection scope of the present application.

Claims

1. A comprehensive separation and purification platform, characterized in that: The invention comprises a separation tower (1), a filtering mechanism (2), a fixed column (3), a lifting assembly (4), a detection element (5) and a control module (6); the interior of the separation tower (1) is hollow; the filtering mechanism (2) is arranged at the upper part of the inner cavity of the separation tower (1); the input port of the filtering mechanism (2) is connected to the feed pipe (11) of the separation tower (1); and the output port of the filtering mechanism (2) is provided with a feed pipe (12); the fixed column (3) is fixedly connected to the inner wall of the separation tower (1); the fixed column (3) is located below the filtering mechanism (2); a cavity is formed inside the fixed column (3) and a through opening is provided at the upper part of the cavity; the lifting assembly (4) is arranged in the cavity of the fixed column (3); the lifting part of the lifting assembly (4) fits in the through opening of the cavity of the fixed column (3); the lifting part of the lifting assembly (4) is provided with a An adsorption unit for adsorbing a target substance and a liquid level sensor (41) for detecting the liquid level of a raw material drug are arranged. The side wall of the fixed column (3) is connected with a waste liquid pipe (31) extending out of the separation tower (1) and a connecting pipe (32), and the connecting pipe (32) is located below the waste liquid pipe (31). The output port of the fixed column (3) is provided with a filtering pipe (33) connected to its cavity. The detection element (5) is arranged in the inner cavity of the separation tower (1) and is located below the fixed column (3). The sampling end of the detection element (5) is connected to an end of the filtering pipe (33) extending out of the fixed column (3) and is used to detect the separation result of the target substance. The filtering pipe (33) is also connected to the output pipe (13) of the separation tower (1). The control module (6) is electrically connected to the detection element (5), the lifting component (4) and the liquid level sensor (41). Wherein, the control module (6) is configured as follows: If a separation demand signal for the bulk drug liquid is received, the lifting component (4) is controlled to reset to a preset initial position; After a preset time T1, the lifting component (4) is controlled to descend to a preset position for discharging the bulk drug waste liquid; If the detection value fed back by the liquid level sensor (41) meets the preset liquid level value, the lifting component (4) is controlled to descend to a preset target material discharge position.

2. The comprehensive separation and purification platform according to claim 1, characterized in that: The lifting assembly (4) comprises a hydraulic cylinder (42) and a lifting platform (43); a groove (34) is provided at the bottom of the cavity of the fixed column (3); a cylinder body of the hydraulic cylinder (42) is arranged in the groove (34); a telescopic rod of the hydraulic cylinder (42) is vertically extended upward; the lifting platform (43) is fixedly connected to the end of the telescopic rod of the hydraulic cylinder (42); the adsorption unit is arranged on the upper surface of the lifting platform (43); a limiting groove (431) is provided on the upper surface of the lifting platform (43); the liquid level sensor (41) is arranged in the limiting groove (431); and a detection end of the liquid level sensor (41) is vertically extended upward and extends out of the limiting groove (431).

3. The comprehensive separation and purification platform according to claim 1, characterized in that: The inner wall of the filtering pipe (33) is fixedly connected with a filter screen (35), and the upper surface of the filter screen (35) is provided with a fixed phase. The bottom of the separation tower (1) is provided with a three-way reversing valve (7), and the three-way reversing valve (7) is located below the detection element (5). The input port of the three-way reversing valve (7) is connected to the lower end of the filtering pipe (33) and is used to receive liquid flowing out of the filtering pipe (33). The output port of the three-way reversing valve (7) is provided with a first valve (71), a second valve (72) and a third valve (73). The first valve (71) is connected to the second waste liquid pipe (14), and the other end of the second waste liquid pipe (14) is connected to the third valve (73). The end of the separation tower (1) extends out of the separation tower (1), and a circulation component (8) is arranged outside the separation tower (1), the input port of the circulation component (8) is connected to the second valve (72), the output port of the circulation component (8) is connected to the separation tower (1) and the output port is located above the fixed column (3), the third valve (73) is connected to the output pipeline (13) of the separation tower (1), the filtering pipeline (33) is provided with an electromagnetic valve (36), and the electromagnetic valve (36) is arranged between the detection component (5) and the three-way reversing valve, and the control module (6) is electrically connected to the electromagnetic valve (36), the three-way reversing valve and the circulation component (8) respectively; Wherein, the control module (6) is configured as follows: If a detection completion signal output by the detection element (5) is received, the electromagnetic valve (36) is controlled to operate; If the detection value fed back by the detection element (5) does not meet the preset target substance separation requirements, the second valve (72) is controlled to open and the circulation element (8) is activated; If the detection value fed back by the detection element (5) meets the preset target substance separation requirements, the third valve (73) is controlled to open; After a preset time period T2, the first valve (71) is controlled to open.

4. The comprehensive separation and purification platform according to claim 3, characterized in that: The circulation component (8) comprises a circulation tank (81) and a reflux pipe (82) arranged outside the separation tower (1); the interior of the circulation tank (81) is hollow and connected to a circulation pump; the input port of the circulation tank (81) is connected to the second valve (72) via a pipe; one end of the reflux pipe (82) is connected to the output end of the circulation tank (81); and the other end of the reflux pipe (82) is extended toward the upper part of the fixed column (3) and communicated with the inner cavity of the separation tower (1); and the connection point is located above the fixed column (3).

5. The comprehensive separation and purification platform according to claim 1, characterized in that: The filtering mechanism (2) comprises a filtering assembly (21) and a filtering tank (22); the filtering tank (22) is vertically arranged in the inner cavity of the separation tower (1); the interior of the filtering tank (22) is hollow and an opening is arranged on the upper surface of the filtering tank (22); a protective cover (221) is arranged at the opening of the filtering tank (22); the feed pipe (11) of the separation tower (1) is passed through the protective cover (221) and extends into the inner cavity of the filtering tank (22); the feed pipe (12) is arranged at the bottom of the filtering tank (22); the upper end of the feed pipe (12) is communicated with the inner cavity of the filtering tank (22); and the filtering assembly (21) is arranged in the inner cavity of the filtering tank (22).

6. The comprehensive separation and purification platform according to claim 5, characterized in that: The filter assembly (21) comprises a fixed block (211) and a filter membrane (212); the fixed block (211) is fixedly connected to the inner wall of the filter tank (22); the fixed block (211) is provided with a plurality of filter holes extending through it in a vertical direction; the upper surface of the fixed block (211) is protruding in an arc shape; and the filter membrane (212) is arranged on the upper surface of the fixed block (211).

7. The comprehensive separation and purification platform according to claim 6, characterized in that: The inner wall of the separation tower (1) is fixedly connected with a liquid storage tank and a suction pump, and the side wall of the filter tank (22) is provided with a drainage pipe (222), one end of the drainage pipe (222) is connected to the inner cavity of the filter tank (22), and the connection point is located at the lowest point of the arc-shaped protrusion of the fixed block (211), the other end of the drainage pipe (222) is connected to the input port of the liquid storage tank, and the output port of the liquid storage tank is connected to the suction pump through a pipeline, and the pipeline of the suction pump is fixedly penetrated through the protective cover (221), and the separation tower (1) is provided with a waste liquid pipe three (223), and the waste liquid pipe three (223) is located below the drainage pipe (222), and the waste liquid pipe three (223) One end is connected to the lower end of the drainage pipe (222), and the other end of the waste liquid pipe three (223) extends out of the separation tower (1); a distance sensor (224) is fixedly connected to the lower surface of the protective cover (221), and the detection end of the distance sensor (224) is arranged vertically downward; the drainage pipe (222) is provided with an electromagnetic valve two (225) at the connection between the drainage pipe (222) and the filter tank (22); the waste liquid pipe three (223) is provided with an electromagnetic valve three (226) at the connection between the drainage pipe (222); and the control module (6) is electrically connected to the electromagnetic valve two (225), the electromagnetic valve three (226), the suction pump and the distance sensor (224) respectively; Wherein, the control module (6) is configured as follows: If the detection value fed back by the distance measuring sensor (224) meets the preset one-time filtering completion condition within the preset T3 time period, the electromagnetic valve 2 (225) is controlled to open; If the detection value fed back by the distance measuring sensor (224) meets the preset secondary filtering condition, the electromagnetic valve 2 (225) is controlled to be closed and the suction pump is turned on; If the detection value fed back by the distance measuring sensor (224) meets the preset waste liquid discharge condition, the electric measuring valve 2 (225) and the electromagnetic valve 3 (226) are controlled to open.

8. The comprehensive separation and purification platform according to claim 1, characterized in that: A refrigeration unit (15) for reducing the temperature of the inner cavity of the separation tower (1) is fixedly connected to the upper surface of the separation tower (1).

9. A comprehensive separation and purification platform control system, characterized in that: The invention comprises a memory and a processor, wherein the memory stores a computer program that can be loaded by the processor and executed by the integrated separation and purification platform as claimed in any one of claims 1 to 8.

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