Sample analyzer and control method of ultrasonic device thereof

Abstract

The invention is suitable for the field of in vitro diagnostic equipment, and discloses a sample analyzer and a control method of an ultrasonic transducer. A control device of the sample analyzer is configured to control an ultrasonic transducer to execute frequency locking operation in a uniform mixing period of a target liquid, and drive an ultrasonic device to work according to a driving frequency when frequency locking succeeds in the uniform mixing period after it is judged that frequency locking succeeds, so that the target liquid is subjected to ultrasonic uniform mixing, and the target liquid is subjected to ultrasonic uniform mixing. And judging whether the ultrasonic mixing of the target liquid is effective or not according to any one of the following parameters: the frequency locking accumulated time length of the frequency locking operation in the mixing period, the frequency locking accumulated number of times of the frequency locking operation in the mixing period, the residual time length of the mixing period, and the time length for driving the ultrasonic device to work according to the driving frequency when the frequency locking succeeds in the mixing period. According to the invention, the frequency locking success rate in the mixing period is improved, and the accuracy of the sample determination result is ensured by judging whether the ultrasonic mixing of the target liquid is effective or not after the frequency locking is successful.

Description

Technical Field

[0001] The present invention relates to the field of in vitro diagnostic equipment, and in particular to a sample analyzer and a control method for an ultrasonic device in the sample analyzer. Background Art

[0002] The related art provides a sample analyzer, which is provided with an ultrasonic device for ultrasonically mixing a mixed liquid containing at least a sample and a reagent. Since the electromechanical conversion efficiency is highest when the ultrasonic device operates at its resonant frequency, in order for the mixed liquid to achieve the desired mixing effect under the action of ultrasound, the control device of the ultrasonic device needs to have a frequency locking function to control the ultrasonic device to operate at its resonant frequency through frequency tracking. In order to realize the automatic measurement function of the sample, the sample analyzer needs to impose timing restrictions on the operation of each device. In terms of frequency locking design, the related art adopts a phase-locked loop technology with a shorter frequency locking time to reserve sufficient time for stable ultrasonic mixing operations.

[0003] In a single mixing cycle of the related technology, a single frequency locking control method is used, that is: in a single mixing cycle, if a single frequency locking does not meet the preset conditions, it is determined that the frequency locking has failed, and the sample and reagent are discarded for retesting. The use of this solution will cause waste of samples and reagents, and will reduce the measurement throughput of the sample analyzer. If, in order to pursue the success rate of frequency locking, simply by extending the frequency locking time and / or increasing the number of frequency locking operations, it is easy to cause the problem of insufficient stable ultrasound duration, so that the mixing effect of the target liquid does not meet expectations, which will affect the accuracy of the measurement results. Summary of the invention

[0004] The first object of the present invention is to provide a sample analyzer, which aims to solve the technical problem that the related art cannot take into account both the success rate of frequency locking and the accuracy of measurement results.

[0005] To achieve the above object, the present invention provides a solution: a sample analyzer, comprising:

[0006] A sample dispensing device, the sample dispensing device is used to draw a sample from a sample container and distribute at least a portion of the drawn sample to a reaction container;

[0007] A reagent dispensing device, the reagent dispensing device is used to suck the reagent from the reagent container and distribute at least part of the sucked reagent to the reaction container;

[0008] An ultrasonic device, the ultrasonic device comprising a device for ultrasonically mixing a target liquid, the target liquid comprising one of the sample, the reagent, and a mixed liquid containing at least the sample and the reagent;

[0009] a measuring device for measuring a reaction solution prepared from the mixed solution;

[0010] A control device, wherein the control device is configured to control the ultrasonic device to perform the following frequency locking operation during the mixing cycle of the target liquid: control the ultrasonic device to start, and determine whether a preset condition is met according to the working parameters fed back by the ultrasonic device, if yes, determine that the frequency locking is successful and stop the frequency locking operation; if not, adjust the driving frequency of the ultrasonic device, and re-determine whether the preset condition is met; before the preset condition is not met, if the driving frequency of the ultrasonic device is adjusted to exceed a first preset frequency range, restart the ultrasonic device to perform a frequency locking operation again;

[0011] The control device is further configured to: within the mixing cycle and after determining that the frequency locking is successful, drive the ultrasonic device to operate according to the driving frequency when the frequency locking is successful, so as to ultrasonically mix the target liquid, and determine whether the ultrasonic mixing of the target liquid is effective according to any one of the following parameters: the cumulative frequency locking duration of the frequency locking operation within the mixing cycle, the cumulative number of frequency locking operations within the mixing cycle, the remaining duration of the mixing cycle, and the duration of driving the ultrasonic device to operate according to the driving frequency when the frequency locking is successful within the mixing cycle.

[0012] As an embodiment, judging whether the ultrasonic mixing of the target liquid is effective according to the accumulated frequency locking time of the frequency locking operation within the mixing cycle includes:

[0013] Determine whether the accumulated frequency locking time of the frequency locking operation in the mixing cycle is less than or equal to a first preset time;

[0014] If yes, it is determined that the ultrasonic mixing of the target liquid is effective;

[0015] If not, it is determined that the ultrasonic mixing of the target liquid is invalid.

[0016] As an implementation manner, the first preset time duration is determined by a measurement item corresponding to the target liquid.

[0017] As an implementation manner, judging whether the ultrasonic mixing of the target liquid is effective according to the cumulative number of frequency locking operations in the mixing cycle includes:

[0018] Determine whether the cumulative number of frequency locking operations in the mixing cycle is less than or equal to a preset number;

[0019] If yes, it is determined that the ultrasonic mixing of the target liquid is effective;

[0020] If not, it is determined that the ultrasonic mixing of the target liquid is invalid.

[0021] As an implementation manner, the preset number of times is determined by the measurement item corresponding to the target liquid.

[0022] As an embodiment, judging whether the ultrasonic mixing of the target liquid is effective according to the duration of driving the ultrasonic device to work according to the driving frequency when the frequency locking is successful within the mixing cycle includes:

[0023] Determine whether the duration of driving the ultrasonic device to work according to the driving frequency when the frequency locking is successful during the mixing cycle is greater than or equal to a second preset duration;

[0024] If yes, it is determined that the ultrasonic mixing of the target liquid is effective;

[0025] If not, it is determined that the ultrasonic mixing of the target liquid is invalid.

[0026] As an embodiment, the control device is further configured to: if it is determined that the ultrasonic mixing of the target liquid is invalid, cancel the measurement item corresponding to the target liquid, and re-measure the measurement item corresponding to the target liquid; or,

[0027] The control device is further configured to: if it is determined that the ultrasonic mixing of the target liquid is invalid, continue to execute the measurement item corresponding to the target liquid, and add a mark to the measurement result corresponding to the target liquid.

[0028] As an embodiment, the preset condition includes that the driving frequency of the ultrasonic device is within a first preset range of the resonant frequency; and / or,

[0029] The preset condition includes that the phase difference between the working current and the working voltage of the ultrasonic device is within a second preset range.

[0030] As an embodiment, the ultrasonic device includes an ultrasonic transducer, an ultrasonic vibrator and a driving mechanism, wherein the ultrasonic vibrator is connected to the ultrasonic transducer to perform ultrasonic mixing on the target liquid under the drive of the ultrasonic transducer;

[0031] The driving mechanism is connected to the ultrasonic transducer and / or the ultrasonic vibrator to at least drive the ultrasonic vibrator to move to the ultrasonic mixing position, so that the ultrasonic vibrator ultrasonically mixes the target liquid at the ultrasonic mixing position;

[0032] The control device is further configured to: before controlling the ultrasonic transducer to perform the frequency locking operation, control the driving mechanism to drive the ultrasonic vibrator to move to the ultrasonic mixing position.

[0033] As an embodiment, the ultrasonic vibrator is an ultrasonic vibrating rod used to be at least partially inserted into the target liquid for ultrasonic mixing.

[0034] As an implementation manner, the ultrasonic vibrator is a component for ultrasonically mixing the target liquid in a non-contact manner.

[0035] As an embodiment, the control device is further configured to adjust the driving frequency of the ultrasonic device in the following manner: the driving frequency after each adjustment is equal to the sum of the driving frequency before the adjustment and the second preset frequency.

[0036] A second object of the present invention is to provide a sample analyzer, the sample analyzer comprising:

[0037] A sample dispensing device, the sample dispensing device is used to draw a sample from a sample container and distribute at least a portion of the drawn sample to a reaction container;

[0038] A reagent dispensing device, the reagent dispensing device is used to suck the reagent from the reagent container and distribute at least part of the sucked reagent to the reaction container;

[0039] An ultrasonic device, the ultrasonic device being used to ultrasonically mix a target liquid, the target liquid comprising one of the sample, the reagent, and a mixed liquid at least comprising the sample and the reagent;

[0040] a measuring device for measuring a reaction solution prepared from the mixed solution;

[0041] A control device, wherein the control device is configured to control the ultrasonic device to perform the following frequency locking operation during the mixing cycle of the target liquid: control the ultrasonic device to start, and determine whether a preset condition is met according to the working parameters fed back by the ultrasonic device, if yes, determine that the frequency locking is successful and stop the frequency locking operation; if not, adjust the driving frequency of the ultrasonic device, and re-determine whether the preset condition is met; before the preset working condition is not met, if the driving frequency of the ultrasonic device is adjusted to exceed a first preset frequency range, restart the ultrasonic device to perform a frequency locking operation again;

[0042] The control device is also configured to: within the mixing cycle and after determining that the frequency locking is successful, determine whether to drive the ultrasonic device to operate according to the driving frequency when the frequency locking is successful, based on the cumulative locking duration of the frequency locking operation within the mixing cycle or the cumulative number of locking times of the frequency locking operation within the mixing cycle or the remaining duration of the mixing cycle, so as to ultrasonically mix the target liquid.

[0043] As an embodiment, judging whether to drive the ultrasonic device to work according to the driving frequency when the frequency locking is successful to ultrasonically mix the target liquid according to the accumulated frequency locking time of the frequency locking operation within the mixing cycle, includes:

[0044] Determine whether the accumulated frequency locking time of the frequency locking operation in the mixing cycle is less than or equal to a first preset time;

[0045] If yes, driving the ultrasonic device to work according to the driving frequency when the frequency is successfully locked, so as to ultrasonically mix the target liquid;

[0046] If not, the ultrasonic mixing operation on the target liquid is canceled.

[0047] As an implementation manner, judging whether to drive the ultrasonic device to work according to the driving frequency when the frequency locking is successful to ultrasonically mix the target liquid according to the accumulated number of frequency locking operations in the mixing cycle, includes:

[0048] Determine whether the cumulative number of frequency locking operations in the mixing cycle is less than or equal to a preset number;

[0049] If yes, driving the ultrasonic device to work according to the driving frequency when the frequency is successfully locked, so as to ultrasonically mix the target liquid;

[0050] If not, the ultrasonic mixing operation on the target liquid is canceled.

[0051] A third object of the present invention is to provide a sample analyzer, the sample analyzer comprising:

[0052] A sample dispensing device, the sample dispensing device is used to draw a sample from a sample container and distribute at least a portion of the drawn sample to a reaction container;

[0053] A reagent dispensing device, the reagent dispensing device is used to suck the reagent from the reagent container and distribute at least part of the sucked reagent to the reaction container;

[0054] an assay device for performing a sample assay on a test specimen made of at least a mixture of the sample and the reagent;

[0055] a cleaning liquid supply device, the cleaning liquid supply device being used to supply cleaning liquid to clean one of the sample needle, the reagent needle, the reaction container, and the stirring rod;

[0056] an ultrasonic device, the ultrasonic device being used to transmit ultrasonic waves to a target liquid, the target liquid being one of the sample, the reagent, the mixed liquid and the cleaning liquid;

[0057] A control device, wherein the control device is configured to control the ultrasonic device to perform the following frequency locking operation within the ultrasonic working cycle of the target liquid: control the ultrasonic device to start, and determine whether a preset condition is met according to the working parameters fed back by the ultrasonic device, if yes, determine that the frequency locking is successful and stop the frequency locking operation; if not, adjust the driving frequency of the ultrasonic device, and re-determine whether the preset condition is met; before the preset condition is not met, if the driving frequency of the ultrasonic device is adjusted to exceed a first preset frequency range, restart the ultrasonic device to perform a frequency locking operation again;

[0058] The control device is also configured to: within the ultrasonic working cycle and after determining that the frequency locking is successful, drive the ultrasonic device to work using the driving frequency when the frequency locking is successful, so as to transmit ultrasonic waves to the target liquid, and judge whether the ultrasonic operation of the target liquid is effective based on any one of the following parameters: the cumulative frequency locking duration of the frequency locking operation within the ultrasonic working cycle, the cumulative number of frequency locking times of the frequency locking operation within the ultrasonic working cycle, the remaining duration of the ultrasonic working cycle, and the duration of the ultrasonic device being driven to work using the driving frequency when the frequency locking is successful within the ultrasonic working cycle.

[0059] A fourth object of the present invention is to provide a control method for an ultrasonic device in a sample analyzer, the control method comprising the following steps:

[0060] Control the start of the ultrasonic device;

[0061] According to the working parameters fed back by the ultrasonic device, it is judged whether the preset conditions are met, if yes, it is determined that the frequency locking is successful and the frequency locking operation is stopped; if no, the driving frequency of the ultrasonic device is adjusted, and it is judged again whether the preset conditions are met;

[0062] Before the preset condition is not met, if the driving frequency of the ultrasonic device is adjusted to exceed the first preset frequency range, restarting the ultrasonic device to perform a frequency locking operation again;

[0063] During the mixing cycle, and after determining that the frequency locking is successful, the ultrasonic device is driven to operate using the driving frequency when the frequency locking is successful, so as to ultrasonically mix the target liquid;

[0064] Whether the ultrasonic mixing of the target liquid is effective is determined based on any one of the following parameters: the cumulative frequency locking duration of the frequency locking operation within the mixing cycle, the cumulative number of frequency locking operations within the mixing cycle, the remaining duration of the mixing cycle, and the duration of the ultrasonic device being driven to work at the driving frequency when the frequency locking is successful within the mixing cycle.

[0065] The sample analyzer and the control method of the ultrasonic device in the sample analyzer provided by the present invention, within the mixing cycle of the target liquid, if a single frequency locking operation does not meet the preset conditions, the ultrasonic device is restarted to perform a frequency locking operation again; after the frequency locking is successful, it is further judged whether the ultrasonic mixing of the target liquid is effective according to the cumulative frequency locking time or the cumulative number of frequency locking times or the remaining time of a single mixing cycle or the time for driving the ultrasonic device to work according to the driving frequency when the frequency locking is successful. In this way, on the one hand, when a single frequency locking does not meet the preset conditions, the frequency locking success rate within the mixing cycle is improved through two or more frequency locking operations, thereby avoiding unnecessary waste of samples and reagents and facilitating improving the measurement throughput of the sample analyzer; on the other hand, the accuracy of the sample measurement result can be ensured by judging whether the ultrasonic mixing of the target liquid is effective. BRIEF DESCRIPTION OF THE DRAWINGS

[0066] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the structures shown in these drawings without paying creative work.

[0067] Figure 1 is a schematic diagram of the composition of a sample analyzer provided in Embodiment 1 of the present invention;

[0068] Figure 2 is a structural schematic diagram of a sample analyzer provided in Embodiment 1 of the present invention;

[0069] Figure 3 is a schematic diagram of ultrasonic mixing of a target liquid by an ultrasonic device provided in Embodiment 1 of the present invention;

[0070] Figure 4 is a schematic diagram of the composition of the control device provided in Embodiment 1 of the present invention;

[0071] Figure 5 is a flow chart of a control method of an ultrasonic device provided in Embodiment 1 of the present invention;

[0072] Figure 6 It is a flow chart of a control method of an ultrasonic device provided in Embodiment 2 of the present invention.

[0073] Explanation of the accompanying drawings: 10. Sample analyzer; 100. Ultrasonic device; 110. Ultrasonic transducer; 111. Piezoelectric ceramic component; 120. Ultrasonic vibrator; 200. Control device; 210. Ultrasonic control board; 220. Main control board; 300. Sample dispensing device; 400. Reagent dispensing device; 500. Measurement device; 600. Reagent loading device; 700. Incubation device; 800. Transfer device; 900. Reaction container providing device; 101. Sample management device; 102. Sample transport device; 103. Magnetic separation device; 20. Target liquid; 30. Reaction container. DETAILED DESCRIPTION

[0074] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0075] It should be noted that all directional indications in the embodiments of the present invention (such as up, down, left, right, front, back, etc.) are only used to explain the relative position relationship, movement status, etc. between the components in a certain specific posture. If the specific posture changes, the directional indication will also change accordingly.

[0076] It should also be noted that when an element is referred to as being "fixed on" or "disposed on" another element, it may be directly on the other element or there may be an intermediate element at the same time. When an element is referred to as being "connected to" another element, it may be directly connected to the other element or may be indirectly connected to the other element through an intermediate element.

[0077] In addition, the descriptions of "first", "second", etc. in the present invention are only used for descriptive purposes and cannot be understood as indicating or implying their relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In addition, the technical solutions between the various embodiments can be combined with each other, but they must be based on the ability of ordinary technicians in the field to implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be deemed that such a combination of technical solutions does not exist and is not within the scope of protection required by the present invention.

[0078] Embodiment 1:

[0079] like Figures 1 to 5As shown, the sample analyzer 10 provided in the first embodiment of the present invention includes an ultrasonic device 100, and the ultrasonic device 100 is used to ultrasonically mix the target liquid 20, and the target liquid 20 is one of a sample, a reagent, and a mixed liquid containing at least a sample and a reagent. The ultrasonic device 100 achieves the effect of mixing the target liquid 20 by transmitting ultrasonic waves to the target liquid 20. The use of the ultrasonic device 100 to mix the target liquid 20 has the characteristic of high mixing efficiency, which is conducive to improving the sample measurement efficiency of the sample analyzer 10.

[0080] As an embodiment, the sample analyzer 10 also includes a control device 200, which is configured to control the ultrasonic device 100 to perform a frequency locking operation during the mixing period of the target liquid 20. After the frequency locking is successful, the control device 200 is also configured to control the ultrasonic device 100 to perform an ultrasonic mixing operation on the target liquid 20 during the mixing period of the target liquid 20. The frequency locking operation is mainly used to determine the target driving frequency of the ultrasonic device 100, so that in the ultrasonic mixing operation, the ultrasonic device 100 is driven at the target driving frequency to transmit ultrasonic waves to the target liquid 20, thereby ensuring the effect of ultrasonic mixing. Among them, the target driving frequency is used to characterize that the ultrasonic device 100 operates within a preset range of the resonant frequency. The electromechanical conversion efficiency is highest when the ultrasonic device 100 operates at its resonant frequency.

[0081] As an embodiment, the control device 200 is configured to control the ultrasonic device 100 to perform the following frequency locking operation during the mixing cycle of the target liquid 20: control the ultrasonic device 100 to start, and determine whether the preset conditions are met according to the working parameters fed back by the ultrasonic device 100. If yes, determine that the frequency locking is successful and stop the frequency locking operation; if not, adjust the driving frequency of the ultrasonic device 100, and re-determine whether the preset conditions are met; before the preset conditions are not met, if the driving frequency of the ultrasonic device 100 is adjusted to exceed the first preset frequency range, restart the ultrasonic device 100 to perform the frequency locking operation again. From starting the ultrasonic device 100 to perform the frequency locking operation, to meeting the preset conditions or restarting the ultrasonic device 100 to perform the frequency locking operation again, it is counted as one frequency locking operation. After starting, the ultrasonic device 100 will work at the preset initial driving frequency. In a specific application, when the ultrasonic device 100 starts working, it can be determined whether the preset conditions are met according to the working parameters fed back by the ultrasonic device 100; or it can be determined whether the preset conditions are met according to the working parameters fed back by the ultrasonic device 100 after the ultrasonic device 100 is started and the driving frequency is adjusted. In the related art before the present application, during the frequency locking process of a single mixing cycle, if it is determined that the driving frequency of the ultrasonic device 100 is adjusted to exceed the first preset frequency range, it is directly determined that the frequency locking fails. In the present embodiment, during the frequency locking process of a single mixing cycle, before the frequency locking operation satisfies the preset conditions, if it is determined that the driving frequency of the ultrasonic device 100 is adjusted to exceed the first preset frequency range, the ultrasonic device 100 will be further restarted to perform a frequency locking operation again. In this way, the frequency locking operation is performed twice or more within the mixing cycle of certain measurement items, thereby improving the frequency locking success rate within a single mixing cycle. That is, the present embodiment can improve the frequency locking success rate through a limited number of frequency lockings under the timing constraints of the mixing cycle of the sample analyzer 10, thereby avoiding unnecessary waste of samples and reagents and helping to improve the measurement throughput of the sample analyzer 10.

[0082] As an embodiment, the control device 200 is further configured to: within the mixing cycle, and after determining that the frequency locking is successful, drive the ultrasonic device 100 to work according to the driving frequency when the frequency locking is successful, so as to ultrasonically mix the target liquid 20, and determine whether the ultrasonic mixing of the target liquid 20 is effective according to any of the following parameters: the cumulative frequency locking duration of the frequency locking operation within the mixing cycle, the cumulative number of frequency locking operations within the mixing cycle, the remaining duration of the mixing cycle, and the duration of driving the ultrasonic device 100 to work according to the driving frequency when the frequency locking is successful within the mixing cycle. In this embodiment, within the limited time sequence of the mixing cycle, when a single frequency locking does not meet the preset conditions, multiple frequency lockings are performed until the preset conditions are met or until the remaining duration of the mixing cycle cannot perform another frequency locking operation, and then the frequency locking operation is stopped. In addition, during the mixing cycle, if the frequency is locked successfully, whether the ultrasonic mixing of the target liquid 20 is effective will be further judged based on the cumulative frequency locking time or the cumulative number of frequency locking times or the remaining time of a single mixing cycle, or the time for driving the ultrasonic device 100 according to the driving frequency when the frequency locking is successful. In this way, on the one hand, the frequency locking success rate during the mixing cycle can be improved through two or more frequency locking operations; on the other hand, the accuracy of the sample measurement results can be ensured by judging whether the ultrasonic mixing of the target liquid 20 is effective.

[0083] It should be noted that after the frequency locking is successful, if the effectiveness of the ultrasonic mixing of the target liquid 20 is not judged further based on the cumulative frequency locking time or the cumulative number of frequency locking times or the remaining time of a single mixing cycle or the working time of the ultrasonic device 100 driven by the driving frequency when the frequency locking is successful, but simply by extending the frequency locking time and / or increasing the number of frequency locking operations, it is easy to cause the following problems: simply by extending the frequency locking time and / or increasing the number of frequency locking operations, although the frequency locking is successful, the remaining time in a single mixing cycle cannot meet the time requirement of stable ultrasound (the time requirement of working at the target driving frequency), resulting in the final mixing effect not meeting the expectations, which in turn affects the accuracy of the measurement results.

[0084] As an embodiment, the control device 200 is further configured to adjust the driving frequency of the ultrasonic device 100 in the following manner: the driving frequency after each adjustment is equal to the sum of the driving frequency before the adjustment and the second preset frequency. That is, in the frequency locking operation, if the ultrasonic device 100 is driven to work at the current driving frequency and it is determined that the preset condition is not met, the driving frequency is adjusted in a driving frequency unit step manner, which is easy to control.

[0085] As an implementation mode, the preset condition is a condition for characterizing whether the driving frequency of the ultrasonic device 100 reaches the resonant frequency. When the driving frequency input to the ultrasonic device 100 is the same as the resonant frequency of the dynamic branch of the ultrasonic device 100, the no-load dynamic branch of the ultrasonic device 100 is purely resistive, and the impedance of the ultrasonic device 100 is the smallest at this time. When the ultrasonic device 100 works at its resonant frequency, the electromechanical conversion efficiency is the highest, which is conducive to ensuring that a better ultrasonic mixing effect is achieved in a shorter time.

[0086] As an embodiment, the preset condition includes that the driving frequency of the ultrasonic device 100 is within a first preset range of the resonant frequency; and / or, the preset condition includes that the phase difference between the working current and the working voltage of the ultrasonic device 100 is within a second preset range. The first preset range is that the driving frequency of the ultrasonic device 100 is equal to the resonant frequency of the ultrasonic device 100 or is within a preset range close to the resonant frequency. The second preset range is that the phase difference between the working voltage and the working current of the ultrasonic device 100 is zero or within a preset range close to zero, which can also indicate that the driving frequency of the ultrasonic device 100 is within the first preset range of the resonant frequency.

[0087] As an implementation mode, the control device 200 includes a phase comparison module. The above-mentioned judging whether the preset conditions are met according to the working parameters of the ultrasonic device 100 includes: judging whether the phase difference between the working voltage and the working current of the ultrasonic device 100 is zero or within a preset range close to zero according to the working voltage and the working current of the ultrasonic device 100. In a specific application, the waveforms of the working voltage and the working current of the ultrasonic device 100 can be collected by the collection circuit, and the phase comparison module can be used to judge whether the phase difference between the working voltage and the working current of the ultrasonic device 100 is zero or within a preset range close to zero. This method is easy to implement.

[0088] As an embodiment, judging whether the ultrasonic mixing of the target liquid 20 is effective according to the accumulated locking time of the locking operation in the mixing cycle includes: judging whether the accumulated locking time of the locking operation in the mixing cycle is less than or equal to the first preset time; if yes, judging that the ultrasonic mixing of the target liquid 20 is effective; if not, judging that the ultrasonic mixing of the target liquid 20 is invalid. The first preset time is less than or equal to the difference between the duration of the mixing cycle and the second preset time. The second preset time is the time requirement for stable ultrasound. The time for stable ultrasound is the preset time required for the measurement project to drive the ultrasonic device 100 to work at the target driving frequency, that is, the time required for the ultrasonic device 100 to work at the resonant frequency. The first preset time may be different for different measurement projects. After the frequency is locked successfully, and when it is judged that the ultrasonic mixing of the target liquid 20 is effective, the driving frequency when the frequency is locked successfully can be directly used as the target driving frequency to drive the ultrasonic device 100 to work, or the target driving frequency can be determined according to the driving frequency when the frequency is locked successfully to drive the ultrasonic device 100 to work. In this embodiment, the accumulated frequency locking time of the frequency locking operation is used as a basis for further judging whether the ultrasonic mixing of the target liquid 20 is effective. This method is simple to control and easy to implement.

[0089] As an implementation mode, the first preset time length is determined by the measurement item corresponding to the target liquid 20. Since different measurement items may have different stable ultrasonic time requirements for the target liquid 20, the first preset time length is set in accordance with each measurement item in this implementation mode, so that the frequency locking control mode in this implementation mode can adapt to the stable ultrasonic time requirements of different measurement items.

[0090] As an implementation method after determining that the ultrasonic mixing is invalid, the control device 200 is further configured to: if it is determined that the ultrasonic mixing of the target liquid 20 is invalid, cancel the execution of the measurement item corresponding to the target liquid 20, and re-measure the measurement item corresponding to the target liquid 20. In this implementation method, after the frequency is locked successfully and the ultrasonic mixing is determined to be invalid, the target liquid 20 is directly invalidated, and the ultrasonic mixing operation and measurement are no longer performed on the target liquid 20.

[0091] As another implementation method after determining that the ultrasonic mixing is invalid, the control device 200 is further configured to: if it is determined that the ultrasonic mixing of the target liquid 20 is invalid, continue to execute the measurement item corresponding to the target liquid 20, and add a mark to the measurement result corresponding to the target liquid 20. In this embodiment, after the frequency is locked successfully and the ultrasonic mixing is determined to be invalid, the target liquid 20 is not invalidated, and the ultrasonic mixing operation and measurement are continued on the target liquid 20, and a mark is added to the measurement result. The mark is used to remind the operator that the ultrasonic mixing in the measurement result is invalid.

[0092] As another implementation after determining that ultrasonic mixing is invalid, the control device 200 is further configured to record a log of invalid ultrasonic mixing if it is determined that ultrasonic mixing of the target liquid 20 is invalid. In this implementation, by recording a log of invalid ultrasonic mixing, it is convenient for the operator to check the reason for the invalid ultrasonic mixing later.

[0093] As an embodiment, the control device 200 is also configured to: for at least two different measurement items and / or at least two different working modes of the sample analyzer 10, when it is determined that the ultrasonic mixing of the target liquid 20 is invalid, take different processing measures respectively, and the different processing measures include at least two of the following processing measures: a first processing measure, a second processing measure, and a third processing measure. Among them, the first processing measure includes: canceling the measurement of the target liquid 20, re-testing the sample measurement item corresponding to the target liquid 20, or, the first processing measure includes: canceling the measurement of the target liquid 20, re-testing the sample measurement item corresponding to the target liquid 20, and recording a log of invalid ultrasonic mixing. The second processing measure includes: continuing to perform the measurement of the target liquid 20, adding a mark to the measurement result corresponding to the target liquid 20, or, the second processing measure includes: continuing to perform the measurement of the target liquid 20, adding a mark to the measurement result corresponding to the target liquid 20, and recording a log of invalid ultrasonic mixing. The third processing measure includes: recording a log of invalid ultrasonic mixing. In specific applications, different treatment measures can be set for different measurement items according to their different requirements for ultrasonic mixing, so as to meet the needs of different measurement items and avoid unnecessary waste of samples and reagents. For example: for measurement items with relatively high requirements for ultrasonic mixing effects, the first treatment measure can be adopted; for measurement items with relatively low requirements for ultrasonic mixing effects, the second treatment measure can be adopted; for measurement items with basically no requirements for ultrasonic mixing effects, the third treatment measure can be adopted. Of course, in specific applications, as an alternative implementation scheme, the sample analyzer 10 can also only set one or two of the first treatment measure, the second treatment measure, and the third treatment measure.

[0094] As an embodiment, the at least two different working modes of the sample analyzer 10 include a sample measurement mode and a debugging mode. The sample measurement mode is a mode for performing sample measurement, and the debugging mode is a mode for debugging the sample analyzer 10. The sample measurement mode can select one of the first processing measure, the second processing measure, and the third processing measure according to different measurement items. The debugging mode can select one of the first processing measure and the third processing measure.

[0095] As an implementation manner, the working mode of the sample analyzer 10 further includes a quality control mode. The quality control mode can select one of the first processing measure, the second processing measure, and the third processing measure according to different quality control items.

[0096] As an embodiment, the ultrasonic device 100 includes an ultrasonic transducer 110 and an ultrasonic vibrator 120, the ultrasonic vibrator 120 is connected to the ultrasonic transducer 110, and the ultrasonic vibrator 120 is used to ultrasonically mix the target liquid 20 under the drive of the ultrasonic transducer 110. The control device 200 is electrically connected to the ultrasonic transducer 110 to control the operation of the ultrasonic transducer 110. The ultrasonic transducer 110 is an energy conversion device, which is mainly used to convert the electrical power input by the control device 200 into mechanical power (i.e., ultrasonic waves) and then transmit it out.

[0097] As an implementation mode, the ultrasonic transducer 110 includes a piezoelectric ceramic component 111. The piezoelectric ceramic component 111 is a component made of an electronic ceramic material having piezoelectric and sensitive properties, and can realize mutual conversion between mechanical energy and electrical energy.

[0098] As an embodiment, the ultrasonic vibrator 120 is an ultrasonic vibrator rod for at least partially inserting into the target liquid 20 for ultrasonic mixing. The ultrasonic vibrator 120 transmits ultrasonic waves to the target liquid 20 in a contact manner to achieve ultrasonic mixing of the target liquid 20, which helps to reduce the interference of other external components on the ultrasonic transmission. Of course, in specific applications, the arrangement of the ultrasonic vibrator 120 is not limited to this. For example, as an alternative embodiment, the ultrasonic vibrator 120 is a component for ultrasonically mixing the target liquid 20 in a non-contact manner, and its specific form includes but is not limited to the following situations: an ultrasonic mixing seat for placing a reaction container 30 loaded with the target liquid 20, a vibration rod for transmitting ultrasonic waves to the target liquid 20 from the side of the outside of the reaction container 30 loaded with the target liquid 20, and a vibration rod for inserting into the reaction container 30 loaded with the target liquid 20 but not inserting into the target liquid 20.

[0099] As an implementation mode, the ultrasonic vibration rod is a horn. The end surface of the ultrasonic vibration rod at one end away from the ultrasonic transducer 110 is the main output surface of the ultrasonic vibration rod for transmitting ultrasonic waves outward.

[0100] As an implementation manner, the ultrasonic device 100 further includes a driving mechanism, the ultrasonic transducer 110 and / or the ultrasonic vibrator 120 are connected to the driving mechanism, and the driving mechanism is used to drive the ultrasonic transducer 110 and the ultrasonic vibrator 120 to move.

[0101] As an implementation manner, the driving mechanism is at least used to drive the ultrasonic vibrator 120 to move to the ultrasonic mixing position, so that the ultrasonic vibrator 120 ultrasonically mixes the target liquid 20 at the ultrasonic mixing position.

[0102] As an implementation manner, the control device 200 is further configured to: before controlling the ultrasonic transducer 110 to drive the ultrasonic vibrator 120 to perform the ultrasonic mixing operation, control the driving mechanism to drive the ultrasonic vibrator 120 to move to the ultrasonic mixing position.

[0103] As an implementation, the control device 200 is further configured to: before controlling the ultrasonic transducer 110 to perform the frequency locking operation, control the driving mechanism to drive the ultrasonic vibrator 120 to move to the ultrasonic mixing position. Of course, in a specific application, as an alternative implementation, the frequency locking operation does not necessarily have to be performed at the ultrasonic mixing position.

[0104] As an implementation mode, the driving mechanism is used to drive the ultrasonic vibrator 120 to move in two-dimensional or three-dimensional space, so that the ultrasonic vibrator 120 moves to different working positions, such as a standby position, an ultrasonic mixing position, a cleaning position, etc.

[0105] As an embodiment, the sample analyzer 10 further includes a sample dispensing device 300, which is used to draw a sample from a sample container and distribute at least part of the drawn sample to a reaction container 30. The sample container is used to load a sample collected from a patient. The reaction container 30 is used to carry the sample for reaction and / or measurement. The sample dispensing device 300 is mainly used to achieve quantitative distribution of the sample.

[0106] As an implementation manner, the sample distributing device 300 is used to draw samples from a sample container located at a sample aspirating position and distribute them to a reaction container 30 located at a sample adding position.

[0107] As an embodiment, the sample dispensing device 300 includes a sample needle, a first motion driving device and a first suction and discharge driving device, wherein the first motion driving device is used to drive the sample needle to move in two-dimensional or three-dimensional space so as to move the sample needle to different positions, such as a standby position, a sample suction position, a sample addition position, a cleaning position, etc. The first suction and discharge driving device is used to drive the sample needle to perform suction and discharge actions.

[0108] As an embodiment, the sample analyzer 10 further includes a reagent dispensing device 400, which is used to absorb reagents from a reagent container and distribute at least part of the absorbed reagents to the reaction container 30. The reagent container is used to store reagents required for the assay. The reagent dispensing device 400 is mainly used to achieve quantitative distribution of reagents.

[0109] As an embodiment, the reagent dispensing device 400 includes a reagent needle, a second motion drive device and a second suction and discharge drive device, and the second motion drive device is used to drive the reagent needle to move in two-dimensional or three-dimensional space, so that the reagent needle moves to different workstations, such as a standby position, a reagent suction position, a reagent addition position, a cleaning position, etc. The second suction and discharge drive device is used to drive the reagent needle to perform suction and discharge actions. It should be noted that the reagent dispensing device 400 may include multiple reagent needles, multiple groups of second motion drive devices and multiple groups of second suction and discharge drive devices, and any two reagent needles can be used to absorb and dispense different types of reagents, respectively, or can be used to absorb and dispense the same type of reagent at different times.

[0110] As an embodiment, the sample analyzer 10 further includes a reagent loading device 600 for storing reagent containers. The reagent dispensing device 400 is used to absorb reagents from the reagent containers on the reagent loading device 600 and distribute at least part of the absorbed reagents into the reaction container 30.

[0111] As an implementation manner, the reagent loading device 600 is in the shape of a disk, and a plurality of reagent positions are formed thereon, and a plurality of reagent containers can be stored simultaneously.

[0112] As an embodiment, the sample analyzer 10 further includes a measuring device 500, which is used to measure the reaction solution made of at least the mixed solution. The measuring device 500 is used to measure the reaction solution in the reaction container 30. The measuring device 500 may be an optical measuring device 500.

[0113] As an embodiment, the sample analyzer 10 further includes an incubation device 700 and a transfer device 800. The incubation device 700 is used to incubate the liquid in the reaction container 30. The transfer device 800 is used to transfer the reaction container 30, for example, to transfer the reaction container 30 after sample addition to the incubation device 700. The reagent dispensing device 400 is used to dispense the reagent into the reaction container 30 located on the incubation device 700. The measuring device 500 is arranged beside the incubation device 700, so as to perform optical measurement on the reaction liquid in the reaction container 30 on the incubation device 700.

[0114] As an embodiment, the incubation device 700 is disc-shaped and has a plurality of incubation holes formed thereon, so that a plurality of reaction containers 30 can be incubated simultaneously.

[0115] As an embodiment, the incubation device 700 is a disc-shaped structure that can drive the reaction container 30 to rotate.

[0116] As an embodiment, the ultrasonic mixing station is located on the incubation device 700. The ultrasonic device 100 is used to ultrasonically mix the target liquid 20 in the reaction container 30 on the incubation device 700. Of course, in a specific application, as an alternative embodiment, the ultrasonic mixing station may not be located on the incubation device 700.

[0117] As an embodiment, the transfer device 800 includes at least one clamping component and at least one third motion driving device for driving the clamping component to move.

[0118] As an embodiment, the sample analyzer 10 also includes a reaction container providing device 900 and a reaction container 30 recovery device, the reaction container providing device 900 is used to provide the reaction container 30, and the reaction container 30 recovery device is used to recover the reaction container 30. The sample analyzer 10 also forms a recovery position, and the reaction container 30 recovery device is located below the recovery position. The transfer device 800 is also used to transfer the reaction container 30 from the incubation device 700 to the recovery position for release and recovery. In this embodiment, the reaction container 30 is a disposable container, that is, a reaction container 30 is recycled after completing a measurement project. Of course, in specific applications, the reaction container 30 can also be a recycled container, that is, the reaction container 30 completes a measurement project, can be cleaned in the sample analyzer 10 and then reused for other measurement projects.

[0119] As an embodiment, the sample analyzer 10 also includes a sample management device 101 and a sample transport device 102. The sample management device 101 is used to place a sample container loaded with a sample to achieve sample loading and storage. The sample transport device 102 is used to transport the sample container output by the sample management device 101 to the sample suction position.

[0120] As an embodiment, the control device 200 includes an ultrasonic control board 210 and a main control board 220. The ultrasonic control board 210 is used to control the operation of the ultrasonic device 100, and the main control board 220 is used to control at least the operation of the ultrasonic control board 210, the sample dispensing device 300, the reagent dispensing device 400, and the measuring device 500. In this embodiment, the ultrasonic control board 210 and the main control board 220 are two independent circuit boards. Of course, in a specific application, as an alternative embodiment, the ultrasonic control board 210 and the main control board 220 can also be integrated into one circuit board.

[0121] As an embodiment, the main control board 220 is also used to control the operation of the incubation device 700 , the transfer device 800 , the magnetic separation device 103 , the reaction container providing device 900 , the sample management device 101 and the sample transport device 102 .

[0122] As an embodiment, the sample is a blood sample, the sample analyzer 10 is an immunoanalyzer, and the sample analyzer 10 also includes a magnetic separation device 103, which is used to magnetically separate the liquid in the reaction container 30. The liquid treated by the magnetic separation device 103 includes a clear liquid and a magnetic bead liquid, the clear liquid is treated as a waste liquid, and the magnetic bead liquid is used to prepare a subsequent reaction liquid. The measurement process of a measurement item in the immunoanalyzer includes: adding a sample, adding a reagent to form a first mixed liquid, mixing and incubating the first mixed liquid to obtain a second mixed liquid, magnetically separating the second mixed liquid to obtain a liquid after magnetic separation, adding a substrate to the liquid after magnetic separation to obtain a third mixed liquid, mixing and incubating the third mixed liquid to obtain a reaction liquid, and optically measuring the reaction liquid. During the magnetic separation process, the operation of adding a separation liquid and mixing will be performed. The above-mentioned mixed liquid as the target liquid 20 includes at least one of the following situations: a first mixed liquid after adding a sample and a reagent and before incubation, a second mixed liquid during the magnetic separation process, and a third mixed liquid formed after the magnetic separation and the addition of a substrate and before incubation. Of course, in a specific application, the type of the sample analyzer 10 is not limited thereto. For example, as an alternative embodiment, the sample analyzer 10 may also be a biochemical analyzer, a blood routine cell analyzer, or a coagulation analyzer.

[0123] The present embodiment also provides a control method for the ultrasonic device 100 in the sample analyzer 10, and the control method includes the following steps: controlling the ultrasonic device 100 to start; judging whether the preset conditions are met according to the working parameters fed back by the ultrasonic device 100, and if so, judging that the frequency locking is successful and stopping the frequency locking operation; if not, adjusting the driving frequency of the ultrasonic device 100, and re-judging whether the preset conditions are met; before the preset conditions are not met, if the driving frequency of the ultrasonic device 100 is adjusted to exceed the first preset frequency range, restarting the ultrasonic device 100 to perform the frequency locking operation again; within the mixing cycle, and after judging that the frequency locking is successful, driving the ultrasonic device 100 to work with the driving frequency when the frequency locking is successful, so as to ultrasonically mix the target liquid 20; judging whether the ultrasonic mixing of the target liquid 20 is effective according to any one of the following parameters: the cumulative frequency locking time of the frequency locking operation within the mixing cycle, the cumulative number of frequency locking times of the frequency locking operation within the mixing cycle, the remaining time of the mixing cycle, and the time of driving the ultrasonic device 100 to work with the driving frequency when the frequency locking is successful within the mixing cycle. In this embodiment, the control method of the ultrasonic device 100 in the sample analyzer 10 is similar to the control principle described in the above sample analyzer 10 and will not be described in detail here.

[0124] As an embodiment, in the above-mentioned control method, whether the ultrasonic mixing of the target liquid 20 is effective is judged based on the cumulative locking time of the frequency locking operation within the mixing cycle, including: judging whether the cumulative locking time of the frequency locking operation within the mixing cycle is less than or equal to the first preset time; if yes, judging that the ultrasonic mixing of the target liquid 20 is effective; if not, judging that the ultrasonic mixing of the target liquid 20 is invalid.

[0125] The specific principles and other implementations of the control method provided in this embodiment are similar to the control principles and implementations described in the above-mentioned sample analyzer 10 and will not be described in detail here.

[0126] This embodiment also provides a computer-readable storage medium, which stores a computer program. When the computer program is executed by a processor (e.g., the processor in the control device 200 described above), the processor implements the steps of the control method of the ultrasonic device 100 in the sample analyzer 10 described above. The computer-readable storage medium may be an internal storage unit of the sample analyzer 10 described above, such as a hard disk or memory of the sample analyzer 10; or, the computer-readable storage medium may also be an external storage device of the sample analyzer 10, such as a plug-in hard disk, a smart memory card (Smart Media Card, SMC), a secure digital (Secure Digital, SD) card, a flash card (FlashCard), etc., equipped on the sample analyzer 10.

[0127] Compared with a single frequency locking judgment, this embodiment increases the frequency locking times of a single target liquid 20 to improve the frequency locking success rate of a single target liquid 20, that is, after judging that the frequency exceeds the limit, it does not directly judge that the frequency locking fails, but re-enters the process of starting the ultrasonic device 100 until the frequency locking is successful or the mixing cycle time is up. And after the frequency locking is successful, it is further judged whether the ultrasonic mixing is effective according to the accumulated frequency locking time, which is conducive to ensuring the accuracy of the measurement results.

[0128] Reference Figure 1 and Figure 5 As shown, as an implementation, the control process of the ultrasonic device 100 includes:

[0129] A. The ultrasonic device 100 is mechanically in place.

[0130] B. Start the ultrasonic device 100, and drive the circuit to the set lower limit frequency f l The ultrasonic device 100 is driven to operate, that is, the driving frequency f at this time is f1.

[0131] C. Signal acquisition: collecting the working current and working voltage signals of the ultrasonic device 100.

[0132] D. Phase detection: The phase comparison module detects the phase of the working current and working voltage signals of the ultrasonic device 100 to identify whether the phase difference Δφ of the working current and working voltage of the ultrasonic device 100 is zero or within a preset range close to zero. If so, proceed to step I; otherwise, proceed to step E.

[0133] E. Driving frequency unit step: the driving frequency is adjusted with a unit frequency Δf, that is, the adjusted driving frequency f=f1+Δf.

[0134] F. Frequency over-limit judgment: judge whether the adjusted driving frequency f exceeds the upper limit frequency f of the first preset frequency range h If yes, go to step B, if no, go to step C.

[0135] G. Determine whether the frequency locking is successful: When Δφ=0 or is within a preset range of 0, the frequency locking is determined to be successful.

[0136] H. Calculation of frequency locking duration t1: The timer calculates the duration from starting the ultrasonic device 100 to successful frequency locking (ie, the cumulative frequency locking duration of the frequency locking operation within the mixing cycle) t1.

[0137] I. Judgment of mixing effectiveness: Compare the frequency locking time t1 with the first preset time t0. The first preset time t0 can be defined by the scene requirement. If t1<t0, it is judged that the ultrasonic mixing is effective. If t1≥t0, it is judged that the ultrasonic mixing is invalid.

[0138] Embodiment 2:

[0139] Reference Figure 1 , Figure 5 and Figure 6 As shown, the sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in the present embodiment are different from those in the first embodiment mainly in that the basis for judging whether the ultrasonic mixing of the target liquid 20 is effective is different, which is specifically reflected in that: in the first embodiment, the cumulative frequency locking time of the frequency locking operation is used as the basis for further judging whether the ultrasonic mixing of the target liquid 20 is effective; while in the present embodiment, the cumulative number of frequency locking times of the frequency locking operation is used as the basis for further judging whether the ultrasonic mixing of the target liquid 20 is effective.

[0140] As an implementation mode, in this embodiment, judging whether the ultrasonic mixing of the target liquid 20 is effective according to the cumulative number of frequency locking operations in the mixing cycle includes: judging whether the cumulative number of frequency locking operations in the mixing cycle is less than or equal to a preset number; if yes, judging that the ultrasonic mixing of the target liquid 20 is effective; if not, judging that the ultrasonic mixing of the target liquid 20 is invalid. In a specific application, when the preset conditions are met during the frequency locking process, judging whether the ultrasonic mixing of the target liquid 20 is effective according to the cumulative number of frequency locking. In this implementation mode, the number of frequency locking is used as a basis for further judging whether the frequency locking fails and whether the frequency locking can be performed again. This method is simple to control and easy to implement.

[0141] As an implementation mode, the preset number of times is determined by the measurement item corresponding to the target liquid 20. The preset number of times N can be calculated according to the formula N=floor[(Tt) / τ], where T is the ultrasonic drive timing requirement, t is the stable ultrasonic duration requirement, τ is the single frequency locking time requirement, and floor[] is a rounding down function, t≤T, τ≤T. In specific applications, the formula N=floor[(Tt) / τ] for calculating the preset number of times can be pre-stored in the sample analyzer 10 in advance, so that the sample analyzer 10 can automatically calculate the preset number of times based on the formula and the input parameters T, t, and τ. Of course, in specific applications, as an alternative implementation mode, the preset number of times can also be pre-stored in the sample analyzer 10 in advance without the need to be calculated according to the formula.

[0142] As an implementation mode, in this embodiment, the control process of the ultrasonic device 100 includes:

[0143] A. The ultrasonic device 100 is mechanically in place.

[0144] B. Start the ultrasonic device 100, and drive the circuit to the set lower limit frequency f l The ultrasonic device 100 is driven to operate, that is, the driving frequency f at this time is f1.

[0145] C. Signal acquisition: collecting the working current and working voltage signals of the ultrasonic device 100.

[0146] D. Phase detection: The phase comparison module detects the phase of the working current and working voltage signals of the ultrasonic device 100 to identify whether the phase difference Δφ of the working current and working voltage of the ultrasonic device 100 is zero or within a preset range close to zero. If so, proceed to step I; otherwise, proceed to step E.

[0147] E. Driving frequency unit step: the driving frequency is adjusted with a unit frequency Δf, that is, the adjusted driving frequency f=f1+Δf.

[0148] F. Frequency over-limit judgment: judge whether the adjusted driving frequency f exceeds the upper limit frequency f of the first preset frequency range h If yes, go to step B, if no, go to step C.

[0149] G. Determine whether the frequency locking is successful: When Δφ=0 or is within a preset range of 0, the frequency locking is determined to be successful.

[0150] H. Calculation of frequency locking times n: Calculate the cumulative frequency locking times n from starting the ultrasonic device 100 to successfully locking the frequency (i.e., the cumulative frequency locking times of the frequency locking operation within the mixing cycle).

[0151] I. Judgment of mixing effectiveness: Compare the cumulative frequency locking times n with the preset times N. If n≤N, it is judged that the ultrasonic mixing is effective; if n>N, it is judged that the ultrasonic mixing is ineffective.

[0152] Except for the above differences, other parts of the sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment can refer to the first embodiment and will not be described in detail here.

[0153] Embodiment three:

[0154] The sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in the present embodiment differ from those in the first embodiment mainly in that the basis for judging whether the ultrasonic mixing of the target liquid 20 is effective is different, which is specifically reflected in that: in the first embodiment, the accumulated frequency locking time of the frequency locking operation is used as the basis for further judging whether the ultrasonic mixing of the target liquid 20 is effective; while in the present embodiment, the stable ultrasonic mixing time after the successful frequency locking is used as the basis for further judging whether the ultrasonic mixing of the target liquid 20 is effective.

[0155] As an implementation mode, in this embodiment, judging whether the ultrasonic mixing of the target liquid 20 is effective according to the duration of driving the ultrasonic device 100 to work according to the driving frequency when the frequency locking is successful during the mixing cycle includes: judging whether the duration of driving the ultrasonic device 100 to work according to the driving frequency when the frequency locking is successful during the mixing cycle is greater than or equal to a second preset duration; if yes, judging that the ultrasonic mixing of the target liquid 20 is effective; if no, judging that the ultrasonic mixing of the target liquid 20 is invalid. The second preset duration is the duration of stable ultrasound required for the measurement item.

[0156] Except for the above differences, other parts of the sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment can refer to the first embodiment and will not be described in detail here.

[0157] Embodiment 4:

[0158] The sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in the present embodiment differ from those in the first embodiment mainly in that the basis for judging whether the ultrasonic mixing of the target liquid 20 is effective is different, which is specifically reflected in that: in the first embodiment, the accumulated frequency locking time of the frequency locking operation is used as the basis for further judging whether the ultrasonic mixing of the target liquid 20 is effective; while in the present embodiment, the stable ultrasonic mixing time after the successful frequency locking is used as the basis for further judging whether the ultrasonic mixing of the target liquid 20 is effective.

[0159] As an implementation mode, in this embodiment, judging whether the ultrasonic mixing of the target liquid 20 is effective according to the duration of driving the ultrasonic device 100 to work according to the driving frequency when the frequency locking is successful during the mixing cycle includes: judging whether the remaining duration of the mixing cycle is greater than or equal to the second preset duration; if yes, judging that the ultrasonic mixing of the target liquid 20 is effective; if no, judging that the ultrasonic mixing of the target liquid 20 is invalid. The second preset duration is the duration of stable ultrasound required for the measurement item.

[0160] Except for the above differences, other parts of the sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment can refer to the first embodiment and will not be described in detail here.

[0161] Embodiment five:

[0162] The sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment are different from those in the first embodiment mainly in that the further operations performed after determining that the frequency locking is successful are different, which is specifically reflected in that: in the first embodiment, after the frequency locking is successful, the further operation is to determine whether the ultrasonic mixing is effective; while in the present embodiment, after the frequency locking is successful, the further operation is to determine whether subsequent ultrasonic mixing of the target liquid 20 is required.

[0163] As an implementation mode, the sample analyzer 10 provided in this embodiment includes a sample dispensing device 300, a reagent dispensing device 400, an ultrasonic device 100, a measuring device 500 and a control device 200. The sample dispensing device 300 is used to draw a sample from a sample container and distribute at least a portion of the drawn sample to a reaction container 30. The reagent dispensing device 400 is used to draw a reagent from a reagent container and distribute at least a portion of the drawn reagent to a reaction container 30. The ultrasonic device 100 is used to ultrasonically mix a target liquid 20, and the target liquid 20 includes one of a sample, a reagent and a mixed liquid containing at least a sample and a reagent. The measuring device 500 is used to measure a reaction liquid made from the mixed liquid. The control device 200 is configured to control the ultrasonic device 100 to perform the following frequency locking operation during the mixing cycle of the target liquid 20: control the ultrasonic device 100 to start, and determine whether the preset conditions are met according to the working parameters fed back by the ultrasonic device 100. If yes, determine that the frequency locking is successful and stop the frequency locking operation; if not, adjust the driving frequency of the ultrasonic device 100, and re-determine whether the preset conditions are met; before the preset working conditions are not met, if the driving frequency of the ultrasonic device 100 is adjusted to exceed the first preset frequency range, restart the ultrasonic device 100 to perform the frequency locking operation again. The control device 200 is also configured to: during the mixing cycle, and after determining that the frequency locking is successful, determine whether to drive the ultrasonic device 100 to work according to the driving frequency when the frequency locking is successful, according to the cumulative frequency locking time of the frequency locking operation in the mixing cycle or the cumulative number of frequency locking operations in the mixing cycle or the remaining time of the mixing cycle, so as to ultrasonically mix the target liquid 20. In this embodiment, when a single frequency locking fails to meet the preset conditions, the ultrasonic device 100 is restarted to perform a frequency locking operation again, so that the frequency locking success rate within the mixing cycle can be improved through two or more frequency locking operations, thereby avoiding unnecessary waste of samples and reagents and improving the measurement throughput of the sample analyzer 10. In addition, after the frequency locking is successful, it is further determined whether the target liquid 20 needs to be further ultrasonically mixed, which helps to avoid the sample analyzer 10 from performing unnecessary operations.

[0164] As an implementation mode, based on the accumulated locking time of the frequency locking operation within the mixing cycle, it is determined whether to use the driving frequency when the frequency locking is successful to drive the ultrasonic device 100 to operate so as to ultrasonically mix the target liquid 20, including: determining whether the accumulated locking time of the frequency locking operation within the mixing cycle is less than or equal to the first preset time; if so, using the driving frequency when the frequency locking is successful to drive the ultrasonic device 100 to operate so as to ultrasonically mix the target liquid 20; if not, canceling the ultrasonic mixing operation on the target liquid 20.

[0165] As another embodiment, based on the cumulative number of frequency locking operations during the mixing cycle, it is determined whether to use the driving frequency when the frequency locking is successful to drive the ultrasonic device 100 to work, so as to ultrasonically mix the target liquid 20, including: determining whether the cumulative number of frequency locking operations during the mixing cycle is less than or equal to a preset number; if so, using the driving frequency when the frequency locking is successful to drive the ultrasonic device 100 to work, so as to ultrasonically mix the target liquid 20; if not, canceling the ultrasonic mixing operation on the target liquid 20.

[0166] As another embodiment, based on the cumulative number of frequency locking operations within the mixing cycle, it is determined whether to use the driving frequency when the frequency locking is successful to drive the ultrasonic device 100 to operate so as to ultrasonically mix the target liquid 20, including: determining whether the remaining duration of the mixing cycle is greater than or equal to a second preset duration; if so, driving the ultrasonic device 100 to operate according to the driving frequency when the frequency locking is successful so as to ultrasonically mix the target liquid 20; if not, canceling the ultrasonic mixing operation on the target liquid 20.

[0167] Except for the above differences, other parts of the sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment can refer to the first to fourth embodiments and will not be described in detail here.

[0168] Embodiment six:

[0169] The sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment are different from those in the first embodiment mainly in that the setting function of the ultrasonic device 100 is different, which is specifically reflected in that: in the first embodiment, the ultrasonic device 100 is used to ultrasonically mix the target liquid 20; while in this embodiment, the ultrasonic device 100 is used to transmit ultrasonic waves to the target liquid 20 to clean the parts to be cleaned.

[0170] As an implementation mode, the sample analyzer 10 provided in this embodiment includes a sample dispensing device 300, a reagent dispensing device 400, a cleaning liquid supply device, an ultrasonic device 100, a measuring device 500 and a control device 200. The sample dispensing device 300 includes a sample needle, which is used to draw a sample from a sample container and distribute at least a portion of the drawn sample to a reaction container 30; the reagent dispensing device 400 includes a reagent needle, which is used to draw a reagent from a reagent container and distribute at least a portion of the drawn reagent to a reaction container 30; the measuring device 500 is used to perform sample measurement on a specimen made of at least a mixed liquid of a sample and a reagent. The cleaning liquid supply device is used to supply a cleaning liquid to clean one of the sample needle, the reagent needle, the reaction container 30 and the stirring rod. The ultrasonic device 100 is used to transmit ultrasonic waves to a target liquid 20, and the target liquid 20 is a cleaning liquid. The measuring device 500 is used to measure a reaction liquid made of at least a mixed liquid. The control device 200 is configured to control the ultrasonic device 100 to perform the following frequency locking operation within the ultrasonic working cycle of the target liquid 20: control the ultrasonic device 100 to start, and determine whether the preset conditions are met according to the working parameters fed back by the ultrasonic device 100. If yes, determine that the frequency locking is successful and stop the frequency locking operation; if not, adjust the driving frequency of the ultrasonic device 100, and re-determine whether the preset conditions are met; before the preset conditions are not met, if the driving frequency of the ultrasonic device 100 is adjusted to exceed the first preset frequency range, restart the ultrasonic device 100 to perform the frequency locking operation again. Frequency locking operation; the control device 200 is further configured to: within the ultrasonic working cycle, and after determining that the frequency locking is successful, drive the ultrasonic device 100 to work using the driving frequency when the frequency locking is successful, so as to transmit ultrasonic waves to the target liquid 20, and determine whether the ultrasonic operation of the target liquid 20 is effective according to any of the following parameters: the cumulative frequency locking time of the frequency locking operation within the ultrasonic working cycle, the cumulative number of frequency locking operations within the ultrasonic working cycle, the remaining time of the ultrasonic working cycle, and the time of driving the ultrasonic device 100 to work using the driving frequency when the frequency locking is successful within the ultrasonic working cycle. In this embodiment, when the ultrasonic device 100 is used for ultrasonic cleaning, in a single ultrasonic working cycle, if the single frequency locking does not meet the preset conditions, the ultrasonic device 100 is restarted to perform the frequency locking operation again until the preset conditions are met or the time limit of the ultrasonic working cycle is reached, so that the frequency locking success rate within the ultrasonic working cycle can be improved by two or more frequency locking operations in combination with the single frequency locking control logic under the ultrasonic working cycle timing limit of the sample analyzer 10. After the frequency is locked successfully, the effectiveness of the ultrasonic operation is further judged to ensure the accuracy of the measurement results.

[0171] As an embodiment, when the ultrasonic device 100 is used to clean the sample needle, the sample analyzer 10 further includes a first cleaning tank, and the cleaning liquid supply device is used to supply cleaning liquid to the first cleaning tank to clean the sample needle. The ultrasonic device 100 includes an ultrasonic transducer 110 and an ultrasonic vibrator 120, and the ultrasonic vibrator 120 is a first ultrasonic seat arranged outside the first cleaning tank, and the first ultrasonic seat is used to transmit ultrasonic waves from outside the first cleaning tank to the cleaning liquid in the first cleaning tank to clean the sample needle inserted into the first cleaning tank.

[0172] As an embodiment, when the ultrasonic device 100 is used to clean the reagent needle, the sample analyzer 10 also includes a second cleaning tank, and the cleaning liquid supply device is used to supply cleaning liquid to the second cleaning tank to clean the reagent needle. The ultrasonic device 100 includes an ultrasonic transducer 110 and an ultrasonic vibrator 120, and the ultrasonic vibrator 120 is a second ultrasonic seat arranged outside the second cleaning tank. The second ultrasonic seat is used to transmit ultrasonic waves from outside the second cleaning tank to the cleaning liquid in the second cleaning tank to clean the reagent needle inserted into the second cleaning tank.

[0173] As an embodiment, when the ultrasonic device 100 is used to clean the stirring rod, the stirring rod is used to stir the sample or reagent or the mixture of the sample and the reagent in the reaction container 30. The sample analyzer 10 also includes a third cleaning tank, and the cleaning liquid supply device is used to supply cleaning liquid to the third cleaning tank to clean the stirring rod. The ultrasonic device 100 includes an ultrasonic transducer 110 and an ultrasonic vibrator 120. The ultrasonic vibrator 120 is a third ultrasonic seat provided outside the third cleaning tank. The third ultrasonic seat is used to transmit ultrasonic waves from outside the third cleaning tank to the cleaning liquid in the third cleaning tank to clean the stirring rod inserted into the third cleaning tank.

[0174] As an embodiment, when the ultrasonic device 100 is used to clean the reaction container 30, the cleaning liquid supply device is used to supply the cleaning liquid to the reaction container 30 to clean the reaction container 30. The ultrasonic device 100 includes an ultrasonic transducer 110 and an ultrasonic vibrator 120, the ultrasonic vibrator 120 is an ultrasonic vibration rod inserted into the reaction container 30 or a fourth ultrasonic seat provided outside the reaction container 30, and the ultrasonic vibrator 120 is used to transmit ultrasonic waves to the cleaning liquid in the reaction container 30 to clean the reaction container 30.

[0175] As an embodiment, the above-mentioned judging whether the ultrasonic operation of the target liquid 20 is valid based on the cumulative frequency locking time of the frequency locking operation within the ultrasonic working cycle includes: judging whether the cumulative frequency locking time of the frequency locking operation within the ultrasonic working cycle is less than or equal to a first preset time; if yes, judging that the ultrasonic operation of the target liquid 20 is valid; if not, judging that the ultrasonic operation of the target liquid 20 is invalid.

[0176] As an embodiment, the above-mentioned judging whether the ultrasonic operation of the target liquid 20 is valid based on the cumulative number of frequency locking operations within the ultrasonic working cycle includes: judging whether the cumulative number of frequency locking operations within the ultrasonic working cycle is less than or equal to a preset number; if so, judging that the ultrasonic operation of the target liquid 20 is valid; if not, judging that the ultrasonic operation of the target liquid 20 is invalid.

[0177] As an embodiment, the above-mentioned method of judging whether the ultrasonic operation of the target liquid 20 is valid according to the duration of time during which the ultrasonic device 100 is driven to work according to the driving frequency when the frequency locking is successful within the ultrasonic working cycle includes: judging whether the duration of time during which the ultrasonic device 100 is driven to work according to the driving frequency when the frequency locking is successful within the ultrasonic working cycle is greater than or equal to a second preset duration; if so, judging that the ultrasonic operation of the target liquid 20 is valid; if not, judging that the ultrasonic operation of the target liquid 20 is invalid.

[0178] As an embodiment, the above-mentioned judging whether the ultrasonic operation of the target liquid 20 is valid based on the remaining duration of the ultrasonic working cycle includes: judging whether the remaining duration of the ultrasonic working cycle is greater than or equal to a second preset duration; if yes, judging that the ultrasonic operation of the target liquid 20 is valid; if not, judging that the ultrasonic operation of the target liquid 20 is invalid.

[0179] The ultrasonic cleaning of this embodiment can adapt to the stable ultrasonic duration requirements of specific measurement items or specific parts to be cleaned under the timing constraints of the sample analyzer 10, and maximize the efficiency and cleanliness of a single ultrasonic cleaning by limiting the number of frequency locks.

[0180] Except for the above differences, other parts of the sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment can refer to the first to fifth embodiments and will not be described in detail here.

[0181] The above description is only a preferred embodiment of the present invention, and does not limit the patent scope of the present invention. All equivalent structural changes made by using the contents of the present invention specification and drawings under the inventive concept of the present invention, or directly / indirectly applied in other related technical fields are included in the patent protection scope of the present invention.

Claims

1. A sample analyzer, characterized in that: include: A sample dispensing device, the sample dispensing device is used to draw a sample from a sample container and distribute at least a portion of the drawn sample to a reaction container; A reagent dispensing device, the reagent dispensing device is used to suck the reagent from the reagent container and distribute at least part of the sucked reagent to the reaction container; An ultrasonic device, the ultrasonic device comprising a device for ultrasonically mixing a target liquid, the target liquid comprising one of the sample, the reagent, and a mixed liquid containing at least the sample and the reagent; a measuring device for measuring a reaction solution prepared from the mixed solution; A control device, wherein the control device is configured to control the ultrasonic device to perform the following frequency locking operation during the mixing period of the target liquid: control the ultrasonic device to start, and determine whether a preset condition is met according to the working parameters fed back by the ultrasonic device, and if so, determine that the frequency locking is successful and stop the frequency locking operation; if not, adjust the driving frequency of the ultrasonic device, and re-determine whether the preset condition is met; Before the preset condition is not met, if the driving frequency of the ultrasonic device is adjusted to exceed the first preset frequency range, restarting the ultrasonic device to perform a frequency locking operation again; The control device is further configured to: within the mixing cycle and after determining that the frequency locking is successful, drive the ultrasonic device to operate according to the driving frequency when the frequency locking is successful, so as to ultrasonically mix the target liquid, and determine whether the ultrasonic mixing of the target liquid is effective according to any one of the following parameters: the cumulative frequency locking duration of the frequency locking operation within the mixing cycle, the cumulative number of frequency locking operations within the mixing cycle, the remaining duration of the mixing cycle, and the duration of driving the ultrasonic device to operate according to the driving frequency when the frequency locking is successful within the mixing cycle.

2. The sample analyzer according to claim 1, wherein: The step of judging whether the ultrasonic mixing of the target liquid is effective according to the accumulated frequency locking time of the frequency locking operation within the mixing cycle includes: Determine whether the accumulated frequency locking time of the frequency locking operation in the mixing cycle is less than or equal to a first preset time; If yes, it is determined that the ultrasonic mixing of the target liquid is effective; If not, it is determined that the ultrasonic mixing of the target liquid is invalid.

3. The sample analyzer according to claim 2, wherein: The first preset time period is determined by the measurement item corresponding to the target liquid.

4. The sample analyzer according to claim 1, wherein: The step of judging whether the ultrasonic mixing of the target liquid is effective according to the accumulated number of frequency locking operations in the mixing cycle includes: Determine whether the cumulative number of frequency locking operations in the mixing cycle is less than or equal to a preset number; If yes, it is determined that the ultrasonic mixing of the target liquid is effective; If not, it is determined that the ultrasonic mixing of the target liquid is invalid.

5. The sample analyzer according to claim 4, characterized in that: The preset number of times is determined by the measurement item corresponding to the target liquid.

6. The sample analyzer according to claim 1, wherein: The determining whether the ultrasonic mixing of the target liquid is effective according to the duration of driving the ultrasonic device to work according to the driving frequency when the frequency locking is successful within the mixing cycle includes: Determine whether the duration of driving the ultrasonic device to work according to the driving frequency when the frequency locking is successful during the mixing cycle is greater than or equal to a second preset duration; If yes, it is determined that the ultrasonic mixing of the target liquid is effective; If not, it is determined that the ultrasonic mixing of the target liquid is invalid.

7. The sample analyzer according to any one of claims 1 to 6, characterized in that: The control device is further configured to: if it is determined that the ultrasonic mixing of the target liquid is invalid, cancel the measurement item corresponding to the target liquid and re-measure the measurement item corresponding to the target liquid; or The control device is further configured to: if it is determined that the ultrasonic mixing of the target liquid is invalid, continue to execute the measurement item corresponding to the target liquid, and add a mark to the measurement result corresponding to the target liquid.

8. The sample analyzer according to claim 1, wherein: The preset condition includes that the driving frequency of the ultrasonic device is within a first preset range of the resonant frequency; and / or, The preset condition includes that the phase difference between the working current and the working voltage of the ultrasonic device is within a second preset range.

9. The sample analyzer according to any one of claims 1 to 6 or 8, characterized in that: The ultrasonic device comprises an ultrasonic transducer, an ultrasonic vibrator and a driving mechanism, wherein the ultrasonic vibrator is connected to the ultrasonic transducer to perform ultrasonic mixing on the target liquid under the drive of the ultrasonic transducer; The driving mechanism is connected to the ultrasonic transducer and / or the ultrasonic vibrator to at least drive the ultrasonic vibrator to move to the ultrasonic mixing position, so that the ultrasonic vibrator ultrasonically mixes the target liquid at the ultrasonic mixing position; The control device is further configured to: before controlling the ultrasonic transducer to perform the frequency locking operation, control the driving mechanism to drive the ultrasonic vibrator to move to the ultrasonic mixing position.

10. The sample analyzer according to claim 9, characterized in that: The ultrasonic vibrator is an ultrasonic vibrating rod used to be at least partially inserted into the target liquid for ultrasonic mixing.

11. The sample analyzer according to any one of claims 1 to 6 or 8, characterized in that: The ultrasonic vibrator is a component for ultrasonically mixing the target liquid in a non-contact manner.

12. The sample analyzer according to any one of claims 1 to 6 or 8, characterized in that: The control device is further configured to adjust the driving frequency of the ultrasonic device in the following manner: the driving frequency after each adjustment is equal to the sum of the driving frequency before the adjustment and the second preset frequency.

13. A sample analyzer, characterized in that: include: A sample dispensing device, the sample dispensing device is used to draw a sample from a sample container and distribute at least a portion of the drawn sample to a reaction container; A reagent dispensing device, the reagent dispensing device is used to suck the reagent from the reagent container and distribute at least part of the sucked reagent to the reaction container; An ultrasonic device, the ultrasonic device being used to ultrasonically mix a target liquid, the target liquid comprising one of the sample, the reagent, and a mixed liquid at least comprising the sample and the reagent; a measuring device for measuring a reaction solution prepared from the mixed solution; A control device, wherein the control device is configured to control the ultrasonic device to perform the following frequency locking operation during the mixing period of the target liquid: control the ultrasonic device to start, and determine whether a preset condition is met according to the working parameters fed back by the ultrasonic device, and if so, determine that the frequency locking is successful and stop the frequency locking operation; if not, adjust the driving frequency of the ultrasonic device, and re-determine whether the preset condition is met; Before the preset working condition is not met, if the driving frequency of the ultrasonic device is adjusted to exceed a first preset frequency range, restarting the ultrasonic device to perform a frequency locking operation again; The control device is also configured to: within the mixing cycle and after determining that the frequency locking is successful, determine whether to drive the ultrasonic device to operate according to the driving frequency when the frequency locking is successful, based on the cumulative locking duration of the frequency locking operation within the mixing cycle or the cumulative number of locking times of the frequency locking operation within the mixing cycle or the remaining duration of the mixing cycle, so as to ultrasonically mix the target liquid.

14. The sample analyzer according to claim 13, wherein: The step of judging whether to drive the ultrasonic device to operate according to the driving frequency when the frequency locking is successful, so as to ultrasonically mix the target liquid, according to the accumulated frequency locking time of the frequency locking operation in the mixing cycle, comprises: Determine whether the accumulated frequency locking time of the frequency locking operation in the mixing cycle is less than or equal to a first preset time; If yes, driving the ultrasonic device to work according to the driving frequency when the frequency locking is successful, so as to ultrasonically mix the target liquid; If not, the ultrasonic mixing operation on the target liquid is canceled.

15. The sample analyzer according to claim 13, wherein: The step of judging whether to drive the ultrasonic device to operate according to the driving frequency when the frequency locking is successful, so as to ultrasonically mix the target liquid, according to the accumulated number of frequency locking operations in the mixing cycle, comprises: Determine whether the cumulative number of frequency locking operations in the mixing cycle is less than or equal to a preset number; If yes, driving the ultrasonic device to work according to the driving frequency when the frequency locking is successful, so as to ultrasonically mix the target liquid; If not, the ultrasonic mixing operation on the target liquid is canceled.

16. A sample analyzer, characterized in that: include: A sample dispensing device, the sample dispensing device is used to draw a sample from a sample container and distribute at least a portion of the drawn sample to a reaction container; A reagent dispensing device, the reagent dispensing device is used to suck the reagent from the reagent container and distribute at least part of the sucked reagent to the reaction container; an assay device for performing a sample assay on a test specimen made of at least a mixture of the sample and the reagent; a cleaning liquid supply device, the cleaning liquid supply device being used to supply cleaning liquid to clean one of the sample needle, the reagent needle, the reaction container, and the stirring rod; an ultrasonic device, the ultrasonic device being used to transmit ultrasonic waves to a target liquid, the target liquid being one of the sample, the reagent, the mixed liquid and the cleaning liquid; A control device, wherein the control device is configured to control the ultrasonic device to perform the following frequency locking operation within the ultrasonic working cycle of the target liquid: control the ultrasonic device to start, and determine whether a preset condition is met according to the working parameters fed back by the ultrasonic device, and if so, determine that the frequency locking is successful and stop the frequency locking operation; if not, adjust the driving frequency of the ultrasonic device, and re-determine whether the preset condition is met; Before the preset condition is not met, if the driving frequency of the ultrasonic device is adjusted to exceed the first preset frequency range, restarting the ultrasonic device to perform a frequency locking operation again; The control device is also configured to: within the ultrasonic working cycle and after determining that the frequency locking is successful, drive the ultrasonic device to work using the driving frequency when the frequency locking is successful, so as to transmit ultrasonic waves to the target liquid, and judge whether the ultrasonic operation of the target liquid is effective based on any one of the following parameters: the cumulative frequency locking duration of the frequency locking operation within the ultrasonic working cycle, the cumulative number of frequency locking times of the frequency locking operation within the ultrasonic working cycle, the remaining duration of the ultrasonic working cycle, and the duration of the ultrasonic device being driven to work using the driving frequency when the frequency locking is successful within the ultrasonic working cycle.

17. A method for controlling an ultrasonic device in a sample analyzer, characterized in that: The steps include: Control the start of the ultrasonic device; According to the working parameters fed back by the ultrasonic device, it is judged whether the preset conditions are met, if yes, it is determined that the frequency locking is successful and the frequency locking operation is stopped; if no, the driving frequency of the ultrasonic device is adjusted, and it is judged again whether the preset conditions are met; Before the preset condition is not met, if the driving frequency of the ultrasonic device is adjusted to exceed the first preset frequency range, restarting the ultrasonic device to perform a frequency locking operation again; During the mixing cycle, and after determining that the frequency locking is successful, the ultrasonic device is driven to operate using the driving frequency when the frequency locking is successful, so as to ultrasonically mix the target liquid; Whether the ultrasonic mixing of the target liquid is effective is determined based on any one of the following parameters: the cumulative frequency locking duration of the frequency locking operation within the mixing cycle, the cumulative number of frequency locking operations within the mixing cycle, the remaining duration of the mixing cycle, and the duration of the ultrasonic device being driven to work at the driving frequency when the frequency locking is successful within the mixing cycle.

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