Oral care product containing bamboo fibers and preparation method thereof

Abstract

The invention discloses an oral care product containing bamboo fiber, the oral care product comprises a friction agent and an antibacterial agent, the friction agent only uses bamboo fiber particles, the antibacterial agent is povidone iodine, and the friction agent in the oral care product is all the bamboo fiber particles prepared by a specific method. No high-hardness abrasives such as silicon dioxide, calcium carbonate and calcium hydrophosphate are used, so that the damage of the abrasives to teeth in the tooth brushing friction process is reduced, and the safety is better. Meanwhile, the adopted povidone iodine serving as an antibacterial agent is a broad-spectrum efficient disinfection preservative, and when the povidone iodine and the antibacterial agent are jointly used in the toothpaste, generated effective iodine can be in full contact with teeth and has a long residence time, and a good effect of inhibiting dental plaque formation is achieved; when the oral care agent is used for brushing teeth, the bamboo fiber particles can mechanically remove dental plaque through friction, the povidone iodine can efficiently remove and inhibit bacterium breeding, and the combination of the bamboo fiber particles and the povidone iodine can effectively inhibit dental plaque generation.

Description

Technical Field

[0001] The invention belongs to the field of oral care, and specifically relates to an oral care product containing bamboo fiber and a preparation method thereof. The oral care product is toothpaste, which uses bamboo fiber as an abrasive and povidone iodine as an antibacterial agent. The toothpaste has good oral cleaning power and antibacterial effect, can reduce the wear on teeth, and effectively inhibit dental plaque. Background Art

[0002] With the continuous development of social economy, people are paying more and more attention to the impact of teeth and oral hygiene on health. Dental caries and periodontal disease are considered to be the most common oral diseases in the world, and dental plaque is the main cause of various oral diseases such as dental caries and periodontal disease. In order to effectively inhibit and remove dental plaque, people often use toothpaste with antibacterial agents to brush their teeth and clean their mouths. Such toothpaste is usually composed of antibacterial substances added to the toothpaste body mainly composed of abrasives, moisturizers, thickeners, foaming agents, aromatics, and water to improve oral health. Most toothpastes on the market use hard and high-density abrasives such as silicon dioxide, calcium carbonate, and calcium hydrogen phosphate as abrasives. The toothpaste products produced will also be denser, and it is difficult to disperse during use, which also affects the penetration of spices in toothpaste products. The taste is poor during use, and long-term use will also cause certain damage and wear to the user's teeth. Such abrasives are usually difficult to disperse in the toothpaste paste for a long time or require a large amount of surfactants to assist in dispersion. At the same time, antibacterial agents for fighting dental plaque are often triclosan, fluoride / stannous chloride, zinc citrate / zinc chloride. Such antibacterial agents are prone to stratification and precipitation when present in the paste for a long time, thus affecting the stability of the toothpaste.

[0003] Therefore, it is very necessary to develop flexible abrasives in the industry, improve the use effect and taste of toothpaste, reduce tooth wear, and use matching antibacterial agents that can be more stably distributed.

[0004] my country is rich in bamboo resources, with high bamboo yield, accounting for about 1 / 3 of the world's bamboo resources. Bamboo has strong regeneration ability, short maturity period, rapid growth, and has the characteristics of permanent utilization after one-time afforestation. At present, bamboo has been partially used in the toothpaste industry. For example, CN117323279A discloses an anti-inflammatory and ulcer prevention toothpaste containing natural plant extracts. Compared with traditional toothpastes containing natural plant extracts added with smilax china extract, pine needle extract and bamboo leaf extract, bamboo leaf extract contains a large amount of flavonoids. Adding bamboo leaves to toothpaste improves the antibacterial and anti-inflammatory effects of toothpaste and prevents oral ulcers. CN103520025A discloses a toothbrush rinse, which is made of wood powder, bamboo powder or plant roots, stems and leaves into powder and salt water into a suspension, and is used to clean teeth and oral cavity by gargling. KR1020240106085A discloses an antibacterial composition containing seaweed extract and natural extract as active ingredients, which contains seaweed extract and natural extract as active ingredients and exhibits antibacterial activity, has excellent oral hygiene and cleaning functions, and the natural extract can be a bamboo extract, which has certain antibacterial activity and can exert excellent oral cleaning power and cleaning power. WO2018206447A1 discloses a toothpaste containing bamboo-based cellulose and thickening silica, which uses 1 to 10 weight % of cellulose particles obtained from bamboo and 1 to 20 weight % of precipitated silica as abrasives, and the oral care cleaner has an excellent cleaning effect on surface stains and tartar on the tooth surface. CN110859779A discloses an oral care product containing plant fiber abrasives, the oral care product includes abrasives, thickeners and moisturizers, the abrasives are plant fiber particles, the thickeners include the moisturizers include polyethylene glycol 1500. This oral care product uses plant fiber particles instead of traditional abrasives and has the characteristics of strong cleaning ability, little damage to teeth and a fine and uniform paste.

[0005] Bamboo fiber is a fiber material extracted from bamboo. It has good hydrophilicity, well-developed pores, large specific surface area, natural antibacterial properties, is non-toxic and pollution-free, has good hygroscopicity and air permeability, and has high specific strength and specific stiffness. However, the bamboo fiber currently used as a substitute is mostly bamboo fiber particles that are natural and have simple processing methods. The main components include cellulose (40% to 60%), hemicellulose (14% to 25%), and lignin (16% to 33%). The presence of hemicellulose and lignin will cause the bamboo fiber to be not highly compatible with other raw materials in oral care products, and may appear coarse or unevenly dispersed, which cannot meet the requirements of toothpaste stability. On the other hand, the particle size of this plant fiber particle is larger than that of traditional abrasives, and it is light in weight, which will bring certain difficulties to the traditional process production, so it is not very conducive to commercial promotion and application. At present, some toothpastes also use microcrystalline cellulose, but the use of microcrystalline cellulose will reduce the wear resistance of cellulose itself and affect the effect as a friction agent on the one hand, and the preparation is complicated on the other hand, which will undoubtedly increase the production cost. CN102429832B discloses a toothpaste, which includes an abrasive composition, a binder, a surfactant, a moisturizer and water, wherein the abrasive composition includes 18-100% of non-thickening microcrystalline cellulose and 0-82% of a traditional abrasive (one or a mixture of calcium carbonate, calcium phosphate, silicon dioxide, etc.). Using microcrystalline cellulose combined with a traditional abrasive as a new type of abrasive is not only conducive to the dispersion of the toothpaste paste, the penetration of the paste fragrance, the improvement of the cleaning power of the toothpaste, and the improvement of the toothpaste taste, but also can reduce the wear of the traditional abrasive on the teeth during long-term use. CN110403851A discloses an anti-sensitive toothpaste, including an abrasive and water, wherein the abrasive is mainly composed of microcrystalline cellulose and hydroxyapatite for blocking dentinal tubules, wherein the content of the microcrystalline cellulose is 1%-50%, and the content of the hydroxyapatite is 1%-50%. Microcrystalline cellulose and hydroxyapatite can play a synergistic role in blocking dentinal tubules, making the toothpaste have a more lasting and firm effect of blocking dentinal tubules.

[0006] Therefore, it is necessary to develop a toothpaste-type oral care agent containing a flexible abrasive and an antibacterial agent and being able to stably exist in the system, so as to improve the use and anti-plaque effect of the toothpaste and reduce tooth wear. Summary of the invention

[0007] The purpose of the present invention is to provide a toothpaste-type oral care agent comprising a bamboo fiber abrasive and a povidone-iodine antibacterial agent. The bamboo fiber abrasive is prepared by a specific method, has abundant hydroxyl groups on the surface, has low hardness, has pores inside the particles, and has a loose material. It can be well combined with the antibacterial agent povidone-iodine, can reduce the wear on teeth during use, improve the dispersion performance of the toothpaste during use, and can effectively and timely release iodine during use, thereby effectively removing dental plaque, maintaining oral hygiene, and improving the cleaning power of the toothpaste.

[0008] To achieve the above purpose, the technical solution adopted by the present invention is: an oral care product containing bamboo fiber, including an abrasive and an antibacterial agent, wherein the abrasive is only bamboo fiber particles, and the antibacterial agent is povidone iodine. In the oral care product, all abrasives are bamboo fiber particles, and abrasives such as silicon dioxide, calcium carbonate, and calcium hydrogen phosphate with high hardness are not used, which reduces the damage of the abrasive to the teeth during the friction process of brushing teeth, and has better safety. At the same time, povidone iodine is a broad-spectrum and efficient disinfectant and preservative, which has a killing effect on bacteria, fungi and viruses. When using toothpaste containing povidone iodine antibacterial agent, the effective iodine produced can fully contact with the teeth and has a long retention time, which has a good effect on inhibiting the formation of dental plaque; when brushing teeth with the oral care agent of the present invention, bamboo fiber particles can mechanically remove dental plaque by friction, and povidone iodine can efficiently remove and inhibit bacterial growth. The combination of the two can effectively inhibit the formation of dental plaque.

[0009] Furthermore, the particle size of the bamboo fiber particles is 10 to 50 μm. The above particle size is conducive to the uniform dispersion of the bamboo fiber particles in the oral care product system. If the particle size is too small, the cleaning ability of the bamboo fiber particles is poor, and the preparation of bamboo fiber particles of this particle size requires high process requirements; if the particle size is too large, the bamboo fiber particles are not easy to be uniformly dispersed in the oral care product system, and the product is prone to precipitation after being placed for a long time.

[0010] The bamboo fiber particles are prepared by the following method: the bamboo material is crushed, passed through an 80-mesh sieve, added to a 0.1 mol / L hydrochloric acid solution, magnetically stirred at room temperature for 24 hours to remove acid-soluble substances, washed with deionized water, filtered and dried to obtain bamboo powder, acid treatment can remove acid-soluble impurities in the bamboo powder, then the bamboo powder is added to a 5%wt sodium hydroxide aqueous solution containing 3wt% sodium bicarbonate, magnetically stirred at 50-70°C for 5-10h, washed with deionized water and filtered and dried to obtain crude bamboo fiber, the present invention uses sodium hydroxide and sodium bicarbonate mixed alkali treatment, compared with a single sodium hydroxide treatment, the introduction of sodium bicarbonate can form a rich pore structure in the micro-nano bamboo powder raw material, the formation of pores in the material can reduce the material density, and facilitate the attachment of povidone iodine. In the present invention, acid and alkali treatment in sequence can remove impurities embedded in fiber cells and hydrolyze lignin and hemicellulose wrapped in cellulose, so that the cellulose is fully exposed. At the same time, the alkaline solution has a strong swelling effect on natural cellulose. The cellulose molecules interact with the alkali, resulting in the destruction of the original hydrogen bonds of the cellulose, the reduction of the supramolecular order, and the changes in the conformation and hydration layer structure of the cellulose chain and swelling. The crude bamboo fiber is dispersed in water to obtain a 1-5wt% suspension, and the suspension is subjected to a continuous cycle grinding treatment for 30 minutes. The grinding disc spacing of the grinder is 0 and the rotation speed is 1500r / min to obtain bamboo fiber particles. The bamboo fiber particles prepared by a specific method have a high cellulose purity, and there are more hydroxyl groups distributed on the surface of the particles. When dispersed in an aqueous solution, it is more conducive to the formation of hydrogen bonds, thereby improving the dispersion stability of the bamboo fiber particles in a system with water as a solvent. The bamboo fiber particles treated by this application have many mesh-like interconnected small holes inside, which is convenient for the adsorption and dispersion of povidone iodine, and improves the stability of the entire toothpaste product. The presence of sodium bicarbonate during the alkali treatment process can also improve the pore distribution inside the bamboo fiber particles to a certain extent, which is more conducive to the attachment and distribution of povidone iodine inside and on the surface of the bamboo fiber abrasive, and improves the stability of povidone iodine in the solution.

[0011] Furthermore, in the preparation method, the mass ratio of bamboo powder to sodium hydroxide is 5 to 20:1.

[0012] Furthermore, the oral care product is a toothpaste, and the toothpaste is composed of the following raw materials in percentage by weight:

[0013] Bamboo fiber particles 15-50 Povidone iodine 1-5 Moisturizer 1-15

[0014] Thickener 0.2~2 Foaming agent 1~4 Fragrance 0.2~1

[0015] Sweetener 0.05~0.15, the balance is water.

[0016] Further, the moisturizing agent is selected from one or more of sorbitol, glycerol, propylene glycol, polyethylene glycol or butylene glycol; the thickener is selected from one or more of ethyl cellulose, methyl cellulose, hydroxypropyl methyl cellulose, sodium carboxymethyl cellulose, cross-linked sodium polyacrylate, guar gum, sodium alginate, carrageenan, guar hydroxypropyl trimethyl ammonium chloride, carrageenan or locust bean gum; the foaming agent is selected from one or more of sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium cocoyl glycinate, sodium acyl glutamate or sodium cocoyl methyl taurate; the fragrance is selected from one or more of tea flavor, mint flavor, fruit flavor, flower flavor and bamboo flavor; the sweetener is selected from one or more of saccharin sodium, sucralose, xylitol, oligofructose, oligosaccharides, oligogalactose, sodium cyclamate, aspartame, stevioside or mogroside.

[0017] Preferably, the toothpaste is composed of the following raw materials in percentage by weight:

[0018] Bamboo fiber particles 40 Povidone iodine 5 Sorbitol 10

[0019] Carrageenan 1 Sodium Cocoyl Glycinate 4 Fruit Flavor 0.5

[0020] Mogroside 0.05, the balance is water.

[0021] Furthermore, the toothpaste is composed of the following raw materials in percentage by weight:

[0022] Bamboo fiber particles 30 Povidone iodine 3 Glycerin 5 Polyethylene glycol 8

[0023] Sodium alginate 0.5 Sodium carboxymethyl cellulose 0.3 Sodium lauryl sulfate 2

[0024] Sodium lauryl sulfate 1 Mint flavor 1 Xylitol 0.1 Aspartame 0.02

[0025] The balance is water.

[0026] Another object of the present invention is to provide a method for preparing the above-mentioned oral care product, which comprises the following steps: 1) preparing bamboo fiber particles: crushing bamboo material, passing through an 80-mesh sieve, adding it to a 0.1 mol / L hydrochloric acid solution, magnetically stirring at room temperature for 24 hours to remove acid-soluble substances, washing with deionized water, filtering and drying to obtain bamboo powder, adding the bamboo powder to a 5%wt sodium hydroxide aqueous solution containing 3wt% sodium bicarbonate, magnetically stirring at 50-70°C for 5-10 hours, washing with deionized water after the end, filtering and drying to obtain crude bamboo fiber; dispersing the crude bamboo fiber in water to obtain a 1-5wt% suspension, subjecting the suspension to a continuous cycle grinding treatment for 30 minutes, with the grinding disc spacing of the grinder being 0 and the rotation speed being 1500r / min, to obtain; 2) taking a certain amount of povidone iodine and bamboo fiber particles, mixing and ball milling for 0.5-2h and then taking them out, and ball milling can be used to mix povidone iodine and bamboo fiber The particles are fully mixed and uniform. First, bamboo fiber has a porous structure, and the internal pores can absorb and accommodate povidone iodine to achieve protection of povidone iodine. In addition, the rich hydroxyl groups on the surface of bamboo fiber can also interact with the iodine in povidone iodine to strengthen the protection of the antibacterial agent povidone iodine in the paste, so that povidone iodine can be stably dispersed in the pores and surface areas of bamboo fiber particles. When the toothpaste is used to clean teeth, the bamboo fiber particles adhere to the surface of the teeth, contact with povidone iodine and water under the action of friction, and begin to release effective iodine, which can eliminate bacteria on the surface of the teeth, and remove the surface plaque by friction to achieve the purpose of cleaning teeth; 3) Take a certain amount of moisturizer, sweetener, and thickener, add them to water in turn, stir and mix evenly, then add the ball milling product obtained in step 2, continue stirring until the suspension is uniform, then add a foaming agent and a fragrance thereto, stir well and evenly, evacuate and stir homogeneously, and then degas to obtain a toothpaste.

[0027] Furthermore, the mass fractions of the components in the toothpaste are as follows:

[0028] Bamboo fiber particles 15-50 Povidone iodine 1-5 Moisturizer 1-15

[0029] Thickener 0.2~2 Foaming agent 1~4 Fragrance 0.2~1

[0030] Sweetener 0.05~0.15, the balance is water.

[0031] Compared with the prior art, the technical solution of the present invention has the following beneficial effects:

[0032] 1. The present invention provides an oral care agent containing bamboo fiber. The oral care agent adopts natural bamboo raw materials to prepare bamboo fiber particles as a friction agent. The raw material source is abundant, and the bamboo raw materials can be effectively utilized. The bamboo fiber particles as a friction agent have the characteristics of low hardness and high friction. In the present invention, the bamboo fiber particles are obtained by a specific method and have better dispersibility in aqueous solution. The formed paste has stronger stability, can also reduce the wear of traditional abrasives on teeth, and enhance the oral cleaning ability and antibacterial effect of toothpaste products.

[0033] 2. The abrasive of the present invention is bamboo fiber particles, which are safer than other inorganic abrasives and will not cause harm to human health after consumption (accidental swallowing); the specific preparation method of the present invention improves the surface properties and internal pore structure of the bamboo fiber particles, making the fiber particles more compatible with the raw materials of oral care products, and there will be no coarsening or uneven dispersion of the paste.

[0034] 3. For the first time, bamboo fiber abrasives and antibacterial agent povidone iodine are used together in oral care agents. The combined use of the two improves the stability of povidone iodine in the system and maintains the long-term effective iodine content. Secondly, when used, povidone iodine can be attached to the surface area of ​​the teeth, and the effective iodine can better contact dental plaque and has a higher antibacterial ability. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 This is a scanning electron microscope (SEM) test image of the bamboo fiber particles prepared in Example 1. DETAILED DESCRIPTION

[0036] In order to make the technical problems solved by the present invention, the technical solutions adopted and the technical effects achieved clearer, the technical solutions of the embodiments of the present invention are further described in detail below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative work are within the scope of protection of the present invention.

[0037] It should be noted that the reference to "embodiment" in this document means that the specific features, structures or characteristics described in conjunction with the embodiment may be included in at least one embodiment of the present application. The appearance of this phrase in various places in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0038] The experimental methods in the following examples are conventional methods unless otherwise specified. The materials and reagents used in the following examples are all commercially available unless otherwise specified. Povidone-iodine powder was purchased from BASF PVP-Iodine 30 / 60M10 (with an effective iodine content of 10.5%).

[0039] The toothpastes of each embodiment and comparative example were tested as follows:

[0040] 1. Stability test: Take an appropriate amount of toothpaste sample, put it into a plastic centrifuge tube, place it in a refrigerator at -8℃±1℃, take it out after 8 hours, randomly put it into a constant temperature incubator at 45℃±1℃, take it out after 8 hours, return to room temperature, open the lid, and check the state of the paste.

[0041] 2. Antibacterial test: Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Streptococcus mutans and Lactobacillus were inoculated into their respective solid culture media with toothpaste particles of 3 mm in diameter in the middle of the culture media. Three parallel samples were prepared for each sample. After 48 hours of culture, the diameter of the inhibition zone was measured and the average value of the three parallel samples was taken.

[0042] Example 1

[0043] A toothpaste containing bamboo fiber is prepared by using the following raw materials in mass fractions:

[0044] Bamboo fiber particles 15% Povidone iodine 1% Sorbitol 1%

[0045] Sodium carboxymethyl cellulose 0.2% Sodium lauryl sulfate 1% Mint flavor 0.2%

[0046] Galacto-oligosaccharide 0.05% and the balance is water.

[0047] The preparation method comprises the following steps: 1) preparing bamboo fiber particles: taking 1000g of bamboo material, crushing it, passing it through an 80-mesh sieve, adding it to 5L of 0.1mol / L hydrochloric acid solution, magnetically stirring it at room temperature for 24 hours to remove acid-soluble substances, washing it with deionized water, filtering it and drying it to obtain bamboo powder, adding the bamboo powder to a 5%wt sodium hydroxide aqueous solution containing 3wt% sodium bicarbonate, the mass ratio of the bamboo powder to the sodium hydroxide is 5:1, magnetically stirring it at 50°C for 5h, washing it with deionized water after the end, filtering it and drying it to obtain crude bamboo fiber; dispersing the crude bamboo fiber in water to obtain a 1wt% suspension, and subjecting the suspension to a continuous cycle grinding treatment for 30min, with the grinding disc spacing of 0. , the speed is 1500r / min, it can be obtained; 2) take 10g of povidone iodine and 150g of the prepared bamboo fiber particles, mix and ball-mill for 0.5h and then take out; 3) take 10g of sorbitol, 0.5g of oligosaccharide, and 2g of sodium carboxymethyl cellulose, add them to 815.5mL of water in sequence, stir and mix evenly, then add the ball-milled product obtained in step 2, continue stirring until the suspension is evenly dispersed, then add 10g of sodium dodecyl sulfate and 2g of mint essence, stir well and evenly, then evacuate and stir homogenously and degas to obtain toothpaste. Figure 1 The scanning electron microscope (SEM) image of the bamboo fiber particles prepared in step 1 shows that there are many mesh-like interconnected small holes inside the bamboo fiber particles treated by this scheme, and the longitudinal surface is rough and has multiple shallow grooves, so that povidone iodine is easy to adhere to it. The toothpaste product was tested. After testing, the toothpaste was stable in shape, without stratification or water precipitation, with appropriate consistency, fine paste, good stability, and the diameters of the inhibition zones for Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Streptococcus mutans and Lactobacillus were 12.5mm, 14.6mm, 17.2mm, and 18.4mm, respectively. It can be seen that the toothpaste has good bactericidal inhibition ability against the main bacteria in dental plaque, and the toothpaste meets the relevant requirements of GB / T8372-2017.

[0048] Example 2

[0049] A toothpaste containing bamboo fiber is prepared by using the following raw materials in mass fractions:

[0050] Bamboo fiber particles 50% Povidone iodine 5% Sorbitol 15%

[0051] Sodium carboxymethyl cellulose 2% Sodium lauryl sulfate 4% Mint flavor 1%

[0052] Galacto-oligosaccharide 0.15% and the balance is water.

[0053] The preparation method comprises the following steps: 1) preparing bamboo fiber particles: taking 1000g of bamboo material, crushing it, passing it through an 80-mesh sieve, adding it to 3L of 0.1mol / L hydrochloric acid solution, magnetically stirring it at room temperature for 24 hours to remove acid-soluble substances, washing it with deionized water, filtering it and drying it to obtain bamboo powder, adding the bamboo powder to a 5%wt sodium hydroxide aqueous solution containing 3wt% sodium bicarbonate, the mass ratio of the bamboo powder to the sodium hydroxide is 20:1, magnetically stirring it at 70°C for 10 hours, washing it with deionized water after the end, filtering it and drying it to obtain crude bamboo fiber; dispersing the crude bamboo fiber in water to obtain a 5wt% suspension, and subjecting the suspension to a continuous cycle grinding treatment for 30 minutes, with a grinding disc spacing of 1 / 4. 0, the speed is 1500r / min, it can be obtained; 2) take 50g of povidone iodine and 500g of the prepared bamboo fiber particles, mix and ball-mill for 2h and then take out; 3) take 150g of sorbitol, 1.5g of oligosaccharide, and 20g of sodium carboxymethyl cellulose, add them to 228.5mL of water in sequence, stir and mix evenly, then add the ball-milled product obtained in step 2, continue stirring until the suspension is evenly dispersed, then add 40g of sodium dodecyl sulfate and 10g of mint essence, stir well and evenly, then evacuate and stir homogenously and degas to obtain toothpaste. After testing, the toothpaste was found to have a stable shape, no stratification or water precipitation, appropriate consistency, fine paste and good stability. The diameters of the inhibition zones for Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Streptococcus mutans and Lactobacillus were 14.2mm, 16.7mm, 21.3mm and 20.2mm respectively. It can be seen that the toothpaste has good bactericidal and inhibitory ability against the main bacteria in dental plaque, and the toothpaste stably meets the relevant requirements of GB / T8372-2017.

[0054] Example 3

[0055] A toothpaste containing bamboo fiber is prepared by using the following raw materials in mass fractions:

[0056] Bamboo fiber particles 40% Povidone iodine 5% Sorbitol 10%

[0057] Carrageenan 1% Sodium Cocoyl Glycinate 4% Fruit Flavor 0.5%

[0058] Mogroside 0.05% and the balance is water.

[0059] The preparation method comprises the following steps: 1) preparing bamboo fiber particles: taking 1000g of bamboo material, crushing it, passing it through an 80-mesh sieve, adding it to 10L of 0.1mol / L hydrochloric acid solution, magnetically stirring it at room temperature for 24 hours to remove acid-soluble substances, washing it with deionized water, filtering it and drying it to obtain bamboo powder, adding the bamboo powder to a 5%wt sodium hydroxide aqueous solution containing 3wt% sodium bicarbonate, the mass ratio of the bamboo powder to the sodium hydroxide is 10:1, magnetically stirring it at 60°C for 8h, washing it with deionized water and filtering it and drying it to obtain crude bamboo fiber; dispersing the crude bamboo fiber in water to obtain a 4wt% suspension, and subjecting the suspension to a continuous cycle grinding treatment for 30min, with a grinding disc spacing of 1.50mm. 0, the speed is 1500r / min, and it can be obtained; 2) take 50g of povidone iodine and 400g of the prepared bamboo fiber particles, mix and ball-mill for 1h and then take out; 3) take 100g of sorbitol, 0.5g of mogroside, and 10g of carboxylic carrageenan, add them to 394.5mL of water in sequence, stir and mix evenly, then add the ball-milled product obtained in step 2, continue stirring until the suspension is evenly dispersed, then add 40g of sodium cocoyl glycinate and 5g of fruit essence, stir well and evenly, then evacuate and stir homogenously and degas to obtain toothpaste. After testing, the toothpaste was found to have a stable shape, no stratification or water precipitation, appropriate consistency, fine paste and good stability. The diameters of the inhibition zones for Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Streptococcus mutans and Lactobacillus were 14.1mm, 16.5mm, 21.5mm and 20.7mm respectively. It can be seen that the toothpaste has good bactericidal and inhibitory ability against the main bacteria in dental plaque, and the toothpaste stably meets the relevant requirements of GB / T8372-2017.

[0060] Example 4

[0061] A toothpaste containing bamboo fiber is prepared by using the following raw materials in mass fractions:

[0062] Bamboo fiber particles 30% Povidone iodine 3% Glycerin 5% Polyethylene glycol 8%

[0063] Sodium alginate 0.5% Sodium carboxymethyl cellulose 0.3% Sodium lauryl sulfate 2%

[0064] Sodium lauryl sulfate 1% Mint flavor 1% Xylitol 0.1%

[0065] Aspartame 0.02% and the balance is water.

[0066] The preparation method comprises the following steps: 1) preparing bamboo fiber particles: taking 1000g of bamboo material, crushing it, passing it through an 80-mesh sieve, adding it to 80L of 0.1mol / L hydrochloric acid solution, magnetically stirring it at room temperature for 24 hours to remove acid-soluble substances, washing it with deionized water, filtering it and drying it to obtain bamboo powder, adding the bamboo powder to a 5%wt sodium hydroxide aqueous solution containing 3wt% sodium bicarbonate, the mass ratio of the bamboo powder to the sodium hydroxide is 15:1, magnetically stirring it at 55°C for 8h, washing it with deionized water after the end, filtering it and drying it to obtain crude bamboo fiber; dispersing the crude bamboo fiber in water to obtain a 3wt% suspension, and subjecting the suspension to a continuous cycle grinding treatment for 30min, the grinding disc spacing of the grinding machine is 0, the rotation speed is 1500r / min, It can be obtained; 2) Take 30g of povidone iodine and 300g of the prepared bamboo fiber particles, mix and ball-mill for 1.5h and then take out; 3) Take 50g of glycerol, 80g of polyethylene glycol, 1g of xylitol, 0.2g of aspartame, 5g of sodium alginate, and 3g of sodium carboxymethyl cellulose and add them to 490.8mL of water in sequence, stir and mix evenly, then add the ball-milled product obtained in step 2, continue stirring until the suspension is evenly dispersed, then add 20g of sodium dodecyl sulfate, 10g of sodium lauryl sulfate, and 10g of mint essence, stir well and evenly, then evacuate and stir homogeneously and degas to obtain toothpaste. After testing, the toothpaste was found to have a stable shape, no stratification or water precipitation, appropriate consistency, fine paste and good stability. The diameters of the inhibition zones for Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Streptococcus mutans and Lactobacillus were 13.3mm, 15.2mm, 18.7mm and 19.6mm respectively. It can be seen that the toothpaste has good bactericidal and inhibitory ability against the main bacteria in dental plaque, and the toothpaste meets the relevant requirements of GB / T8372-2017.

[0067] Comparative Example 1

[0068] Except for replacing the homemade bamboo fiber particles with microcrystalline cellulose purchased from Shanhe Pharmaceutical Co., Ltd., other contents are the same as Example 4. After testing, the toothpaste prepared therefrom has a stable shape, with a small amount of white precipitate stratified, and the diameters of the inhibition zones for Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Streptococcus mutans and Lactobacillus are 10.7 mm, 11.4 mm, 13.9 mm and 15.3 mm, respectively. The toothpaste also has a certain bactericidal and inhibitory ability against the main bacteria in dental plaque, but the antibacterial ability is reduced compared with the bamboo fiber particles used in the embodiment.

[0069] Comparative Example 2

[0070] The difference from Example 4 is that the bamboo powder particles filtered and dried after acid treatment in step 1 replace the bamboo fiber particles in Example 4, and the other contents are the same as Example 4. After testing, the toothpaste prepared therefrom is stratified and has poor stability. The diameters of the inhibition zones for Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Streptococcus mutans and Lactobacillus are 8.2 mm, 9.1 mm, 9.8 mm and 12.5 mm, respectively. The toothpaste also has a certain bactericidal and inhibitory ability against the main bacteria in dental plaque, but the overall stability is poor.

[0071] From the test results of the above embodiments and comparative examples, it can be seen that the oral care product toothpaste prepared in the embodiments of the present application has good stability, outstanding antibacterial ability, and no stratification and precipitation after long-term storage. However, the use of microcrystalline cellulose or directly acid-treated bamboo powder cannot ensure the stability of the toothpaste paste. It is easy to stratify after being stored for a period of time, making the toothpaste ineffective and affecting its use. At the same time, it can also be seen that the bamboo cellulose particles and povidone-iodine compound treated with the specific scheme of the present invention have a certain stability, which can maintain the system's strong inhibition of bacteria in dental plaque.

[0072] The above is a detailed introduction to an oral care product containing bamboo fiber and a preparation method thereof. The above content is a further detailed description of the present invention in combination with a specific preferred embodiment, and it cannot be determined that the specific implementation of the present invention is limited to these descriptions. For ordinary technicians in the technical field to which the present invention belongs, without departing from the concept of the present invention, its architecture can be flexible and can derive a series of products. Just making a few simple deductions or substitutions should be regarded as belonging to the scope of patent protection of the present invention determined by the submitted claims.

Claims

1. An oral care product containing bamboo fiber, characterized in that: The oral care product comprises an abrasive and an antibacterial agent, wherein the abrasive is only bamboo fiber particles and the antibacterial agent is povidone iodine.

2. The oral care product according to claim 1, characterized in that The particle size of the bamboo fiber particles is 10 to 50 μm.

3. The oral care product according to claim 1, characterized in that The bamboo fiber particles are prepared by the following method: crushing bamboo materials, passing through an 80-mesh sieve, adding the materials to a 0.1 mol / L hydrochloric acid solution, subjecting the materials to magnetic stirring at room temperature for 24 hours to remove acid-soluble substances, washing the materials with deionized water, filtering and drying the materials to obtain bamboo powder, adding the bamboo powder to a 5%wt sodium hydroxide aqueous solution containing 3wt% sodium bicarbonate, subjecting the materials to magnetic stirring at 50-70°C for 5-10 hours, washing the materials with deionized water, filtering and drying the materials to obtain crude bamboo fibers; dispersing the crude bamboo fibers in water to obtain a 1-5wt% suspension, subjecting the suspension to continuous cyclic grinding for 30 minutes, with the grinding disc spacing of the grinding machine being 0 and the rotation speed being 1500r / min, to obtain bamboo fiber particles.

4. The oral care product according to claim 3, characterized in that In the preparation method, the mass ratio of bamboo powder to sodium hydroxide is 5-20:

1.

5. The oral care product according to claim 1, characterized in that: The oral care product is toothpaste, which is composed of the following raw materials in percentage by weight: Bamboo fiber particles 15-50 Povidone iodine 1-5 Moisturizer 1-15 Thickener 0.2~2 Foaming agent 1~4 Fragrance 0.2~1 Sweetener 0.05~0.15, the balance is water.

6. The oral care product according to claim 5, characterized in that The moisturizing agent is selected from one or more of sorbitol, glycerol, propylene glycol, polyethylene glycol or butylene glycol; the thickener is selected from one or more of ethyl cellulose, methyl cellulose, hydroxypropyl methyl cellulose, sodium carboxymethyl cellulose, cross-linked sodium polyacrylate, guar gum, sodium alginate, carrageenan, guar hydroxypropyl trimethyl ammonium chloride, carrageenan or locust bean gum; the foaming agent is selected from one or more of sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium cocoyl glycinate, sodium acyl glutamate or sodium cocoyl methyl taurate; the fragrance is selected from one or more of tea flavor, mint flavor, fruit flavor, flower flavor and bamboo flavor; the sweetener is selected from one or more of saccharin sodium, sucralose, xylitol, oligofructose, oligosaccharide, oligogalactose, sodium cyclamate, aspartame, stevioside or mogroside.

7. The oral care product according to claim 6, characterized in that The toothpaste is composed of the following raw materials in percentage by weight: composition: Bamboo fiber granules 40 povidone iodine 5 sorbitol 10 Carrageenan 1 Sodium Cocoyl Glycinate 4 Fruit Flavor 0.5 Mogroside 0.05, the balance is water.

8. The oral care product according to claim 6, characterized in that The toothpaste is composed of the following raw materials in percentage by weight: Bamboo fiber particles 30 Povidone iodine 3 Glycerin 5 Polyethylene glycol 8 Sodium alginate 0.5 Sodium carboxymethyl cellulose 0.3 Sodium lauryl sulfate 2 Sodium lauryl sulfate 1 Mint flavor 1 Xylitol 0.1 Aspartame 0.02 The balance is water.

9. A method for preparing an oral care product according to any one of claims 1 to 8, characterized in that: The method comprises the following steps: 1) preparing bamboo fiber particles: crushing bamboo material, passing through an 80-mesh sieve, adding the mixture into a 0.1 mol / L hydrochloric acid solution, magnetically stirring the mixture for 24 hours at room temperature to remove acid-soluble substances, washing the mixture with deionized water, filtering and drying the mixture to obtain bamboo powder; adding the bamboo powder into a 5%wt sodium hydroxide aqueous solution containing 3wt% sodium bicarbonate, magnetically stirring the mixture for 5-10 hours at 50-70°C, washing the mixture with deionized water, filtering and drying the mixture to obtain crude bamboo fiber; dispersing the crude bamboo fiber into water to obtain a 1-5wt% suspension, and The above suspension is subjected to continuous cycle grinding treatment for 30 minutes, with the grinding disc spacing of the grinder being 0 and the rotation speed being 1500r / min to obtain; 2) taking a certain amount of povidone iodine and bamboo fiber particles, mixing and ball milling for 0.5 to 2h and then taking them out; 3) taking a certain amount of moisturizer, sweetener, and thickener, adding them to water in turn, stirring and mixing evenly, then adding the ball milling product obtained in step 2, continuing to stir until the suspension is uniform, then adding a foaming agent and a fragrance thereto, fully stirring and evenly evacuating and stirring and homogenizing, and then degassing to obtain a toothpaste.

10. The preparation method according to claim 9, characterized in that: The mass fractions of the components in the toothpaste are as follows: Bamboo fiber particles 15-50 Povidone iodine 1-5 Moisturizer 1-15 Thickener 0.2~2 Foaming agent 1~4 Fragrance 0.2~1 Sweetener 0.05~0.15 The balance is water.

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